(center map)
(1) CTBP*@nucleus - ARF**@nucleus ->
(2) ARF**@nucleus+HUWE1@nucleus -> ARF*:HUWE1@nucleus
(3) MYC@nucleus+ARF**@nucleus -> ARF*:MYC@nucleus
(4) active~TP53@nucleus - MDM2@nucleus - ARF**@nucleus - SIVA1 - HUWE1@nucleus - SIRT1@nucleus -> inactive~TP53@nucleus
(5) ARF*@nucleus -> ARF**@nucleus
(6) ARF*@nucleolus -> ARF**@nucleus