(1) rSIVA1@nucleus -> SIVA1 (2) active~TP53@nucleus - MDM2@nucleus - ARF**@nucleus - SIVA1 - HUWE1@nucleus - SIRT1@nucleus -> inactive~TP53@nucleus (3) SIVA1+BCL2L1@mitochondrial outer membrane -> BCL2L1:SIVA1@mitochondrial outer membrane