(center map)
(1) STK11|K48_ace|T366_unk@nucleus - SIRT1@nucleus -> STK11|T366_unk@nucleus
(2) XRCC6|K539_ace|K542_ace@nucleus - SIRT1@nucleus -> XRCC6@nucleus
(3) PPARGC1A|ace@nucleus - SIRT1@nucleus -> PPARGC1A@nucleus
(4) active~TP53@nucleus - MDM2@nucleus - ARF**@nucleus - SIVA1 - HUWE1@nucleus - SIRT1@nucleus -> inactive~TP53@nucleus
(5) SIRT1 -t-> SIRT1@nucleus