(center map)
(1) CYCS+(d)ATP+APAF1 - PTMA - ACHE - AFP - ANP32A - CSE1L - HSP70* -> (d)ATP:APAF1:CYCS
(2) APAF1+HSP70* -> APAF1:HSP70*
(3) HSP70*+cleaved~AIFM1 -> HSP70*:cleaved~AIFM1
(4) lysosome membrane~integrity@lysosome+hydroxyl - HSP70* -> LMP@lysosome