STATE_TRANSITION(re482)

CYCS+(d)ATP+APAF1 - PTMA - ACHE - AFP - ANP32A - CSE1L - HSP70* -> (d)ATP:APAF1:CYCS
center map on reaction (center map)
Comments:

PMID:17377525 review on apoptosome formation PMID:11864614 stoechiometry apoptosome PMID:12522243 inhibition of apoptosome formation by prothymosin-alpha PMID:15087373 in HT-29 colon adenocarcinoma cells, siRNA against ACHE prevents the APAF1 CYCS interaction and etoposide-induced PMID:14622304 AFP positive influence on apoptosome assembly PMID:18439902 CAS PHAPI and HSP70 enhance apoptosome formation and caspase activation


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