1. "CellDesigner." from http://www.systems-biology.org/cd/.
2. "BiNoM." from http://bioinfo-out.curie.fr/projects/binom/.
3. "Cytoscape." from http://www.cytoscape.org/.
4. "BioPAX." from http://www.biopax.org/.
5. "Reactome." from http://www.reactome.org/.
6. "KEGG." from http://www.genome.jp/kegg/.
7. "Transpath." from http://www.biobase-international.com/pages/index.php?id=transpath.
8. "Ingenuity." from http://www.ingenuity.com/.
9. "BioCyc." from http://www.biocyc.org.
10. "Panther." from http://www.pantherdb.org/.
Adams, M. R., R. Sears, et al. (2000). "Complex Transcriptional Regulatory Mechanisms Control Expression of the E2F3 Locus." Mol. Cell. Biol. 20(10): 3633-3639.
Alberts, B., D. Bray, et al. (1994). Molecular Biology of the Cell, Garland Publishing.
Altiok, S., M. Xu, et al. (1997). "PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A." Genes Dev. 11(15): 1987-1998.
Apostolova, M. D., I. A. Ivanova, et al. (2002). "Active Nuclear Import and Export Pathways Regulate E2F-5 Subcellular Localization." J. Biol. Chem. 277(37): 34471-34479.
Aprelikova, O., Y. Xiong, et al. (1995). "Both p16 and p21 Families of Cyclin-dependent Kinase (CDK) Inhibitors Block the Phosphorylation of Cyclin-dependent Kinases by the CDK-activating Kinase." J. Biol. Chem. 270(31): 18195-18197.
Arakawa, Y., K. Kajino, et al. (2004). "Transcription of dbpA, a Y box binding protein, is positively regulated by E2F1: implications in hepatocarcinogenesis." Biochemical and Biophysical Research Communications 322(1): 297-302.
Araki, K., Y. Nakajima, et al. (2003). "Distinct recruitment of E2F family members to specific E2F-binding sites mediates activation and repression of the E2F1 promoter." Oncogene 22(48): 7632-41.
Aslanian, A., P. J. Iaquinta, et al. (2004). "Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics." Genes Dev. 18(12): 1413-1422.
Attwooll, C., E. Lazzerini Denchi, et al. (2004). "The E2F family: specific functions and overlapping interests." Embo J 23(24): 4709-16.
Attwooll, C., S. Oddi, et al. (2005). "A Novel Repressive E2F6 Complex Containing the Polycomb Group Protein, EPC1, That Interacts with EZH2 in a Proliferation-specific Manner." J. Biol. Chem. 280(2): 1199-1208.
Bakkenist, C. J. and M. B. Kastan (2003). "DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation." Nature 421(6922): 499-506.
Balciunaite, E., A. Spektor, et al. (2005). "Pocket Protein Complexes Are Recruited to Distinct Targets in Quiescent and Proliferating Cells." Mol. Cell. Biol. 25(18): 8166-8178.
Banin, S., L. Moyal, et al. (1998). "Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage." Science 281(5383): 1674-1677.
Bartek, J. and J. Lukas (2003). "Chk1 and Chk2 kinases in checkpoint control and cancer." Cancer Cell 3(5): 421-429.
Bartkova, J., Z. Horejsi, et al. (2005). "DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis." Nature 434(7035): 864-870.
Baylin, S. and T. H. Bestor (2002). "Altered methylation patterns in cancer cell genomes: cause or consequence?" Cancer Cell 1(4): 299-305.
Bembenek, J. and H. Yu (2001). "Regulation of the Anaphase-promoting Complex by the Dual Specificity Phosphatase Human Cdc14a." J. Biol. Chem. 276(51): 48237-48242.
Benzeno, S., F. Lu, et al. (2006). "Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1." Oncogene 25(47): 6291-6303.
Berkovich, E. and D. Ginsberg (2003). "ATM is a target for positive regulation by E2F-1." Oncogene 22(2): 161-7.
Berteaux, N., S. Lottin, et al. (2005). "H19 mRNA-like Noncoding RNA Promotes Breast Cancer Cell Proliferation through Positive Control by E2F1." J. Biol. Chem. 280(33): 29625-29636.
Bhattacharya, S., J. Garriga, et al. (2003). "SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells." Oncogene 22(16): 2443-51.
BioPAX_working_group. (2004). "BioPAX-biological pathways exchange language. Level 1, Version 1.0 Documentation." from http://www.biopax.org/.
Blais, A. and B. D. Dynlacht (2004). "Hitting their targets: an emerging picture of E2F and cell cycle control." Current Opinion in Genetics & Development 14(5): 527-532.
Blais, A., D. Monte, et al. (2002). "Regulation of the Human Cyclin-dependent Kinase Inhibitor p18INK4c by the Transcription Factors E2F1 and Sp1." J. Biol. Chem. 277(35): 31679-31693.
Blasina, A., I. V. de Weyer, et al. (1999). "A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase." Current Biology 9(1): 1-10.
Bockstaele, L., H. Kooken, et al. (2006). "Regulated Activating Thr172 Phosphorylation of Cyclin-Dependent Kinase 4(CDK4): Its Relationship with Cyclins and CDK "Inhibitors"." Mol. Cell. Biol. 26(13): 5070-5085.
Booher, R. N., P. S. Holman, et al. (1997). "Human Myt1 Is a Cell Cycle-regulated Kinase That Inhibits Cdc2 but Not Cdk2 Activity." J. Biol. Chem. 272(35): 22300-22306.
Booher, R. N., P. S. Holman, et al. (1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity." J Biol Chem 272(35): 22300-6.
Boyer Arnold, N. and M. Korc (2005). "Smad7 Abrogates Transforming Growth Factor-{beta}1-mediated Growth Inhibition in COLO-357 Cells through Functional Inactivation of the Retinoblastoma Protein." J. Biol. Chem. 280(23): 21858-21866.
Bracken, A. P., D. Pasini, et al. (2003). "EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer." Embo J 22(20): 5323-35.
Brehm, A., E. A. Miska, et al. (1998). "Retinoblastoma protein recruits histone deacetylase to repress transcription." Nature 391(6667): 597-601.
Brown, V. D., R. A. Phillips, et al. (1999). "Cumulative Effect of Phosphorylation of pRB on Regulation of E2F Activity." Mol. Cell. Biol. 19(5): 3246-3256.
Calbo, J., M. Parreno, et al. (2002). "G1 Cyclin/Cyclin-dependent Kinase-coordinated Phosphorylation of Endogenous Pocket Proteins Differentially Regulates Their Interactions with E2F4 and E2F1 and Gene Expression." J. Biol. Chem. 277(52): 50263-50274.
Cam, H. and B. D. Dynlacht (2003). "Emerging roles for E2F: Beyond the G1/S transition and DNA replication." Cancer Cell 3(4): 311-316.
Campanero, M. R., M. Armstrong, et al. (1999). "Distinct Cellular Factors Regulate the c-myb Promoter through Its E2F Element." Mol. Cell. Biol. 19(12): 8442-8450.
Canman, C. E., D.-S. Lim, et al. (1998). "Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53." Science 281(5383): 1677-1679.
Caretti, G., V. Salsi, et al. (2003). "Dynamic Recruitment of NF-Y and Histone Acetyltransferases on Cell-cycle Promoters." J. Biol. Chem. 278(33): 30435-30440.
Castedo, M., J. L. Perfettini, et al. (2002). "Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe." Cell Death Differ 9(12): 1287-93.
Chabes, A. L., S. Bjorklund, et al. (2004). "S Phase-specific Transcription of the Mouse Ribonucleotide Reductase R2 Gene Requires Both a Proximal Repressive E2F-binding Site and an Upstream Promoter Activating Region." J. Biol. Chem. 279(11): 10796-10807.
Chan, H. M. and N. B. La Thangue (2001). "p300/CBP proteins: HATs for transcriptional bridges and scaffolds." J Cell Sci 114(13): 2363-2373.
Chaussepied, M. and D. Ginsberg (2004). "Transcriptional Regulation of AKT Activation by E2F." Molecular Cell 16(5): 831-837.
Chen, C.-R., Y. Kang, et al. (2002). "E2F4/5 and p107 as Smad Cofactors Linking the TGF[beta] Receptor to c-myc Repression." Cell 110(1): 19-32.
Chen, X. and R. Prywes (1999). "Serum-Induced Expression of the cdc25A Gene by Relief of E2F-Mediated Repression." Mol. Cell. Biol. 19(7): 4695-4702.
Chen, Y. and Y. Sanchez (2004). "Chk1 in the DNA damage response: conserved roles from yeasts to mammals." DNA Repair 3(8-9): 1025-1032.
Chestukhin, A., L. Litovchick, et al. (2002). "Nucleocytoplasmic Shuttling of p130/RBL2: Novel Regulatory Mechanism." Mol. Cell. Biol. 22(2): 453-468.
Child, E. S. and D. J. Mann (2006). "The intricacies of p21 phosphorylation: protein/protein interactions, subcellular localization and stability." Cell Cycle 5(12): 1313-9.
Chini, C. C. S. and J. Chen (2003). "Human Claspin Is Required for Replication Checkpoint Control." J. Biol. Chem. 278(32): 30057-30062.
Choi, M., H. Lee, et al. (2002). "E2F1 activates the human p53 promoter and overcomes the repressive effect of hepatitis B viral X protein (Hbx) on the p53 promoter." IUBMB Life 53(6): 309-17.
Christensen, J., P. Cloos, et al. (2005). "Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription." Nucl. Acids Res. 33(17): 5458-5470.
Classon, M. and N. Dyson (2001). "p107 and p130: Versatile Proteins with Interesting Pockets." Experimental Cell Research 264(1): 135-147.
Claudio, P., T. Tonini, et al. (2002). "The retinoblastoma family: twins or distant cousins?" Genome Biology 3(9): reviews3012.1 - reviews3012.9.
Cobrinik, D. (2005). "Pocket proteins and cell cycle control." 24(17): 2796-2809.
Coleman, T. R., Z. Tang, et al. (1993). "Negative regulation of the wee1 protein kinase by direct action of the nim1/cdr1 mitotic inducer." Cell 72(6): 919-29.
Connell-Crowley, L., J. W. Harper, et al. (1997). "Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation." Mol Biol Cell 8(2): 287-301.
Coqueret, O. (2002). "Linking cyclins to transcriptional control." Gene 299(1-2): 35-55.
Croxton, R., Y. Ma, et al. (2002). "Direct repression of the Mcl-1 promoter by E2F1." Oncogene 21(9): 1359-69.
Dabrowska, M. and F. M. Sirotnak (2004). "Regulation of transcription of the human MRP7 gene.: Characteristics of the basal promoter and identification of tumor-derived transcripts encoding additional 5' end heterogeneity." Gene 341: 129-139.
Dahiya, A., S. Wong, et al. (2001). "Linking the Rb and Polycomb Pathways." Molecular Cell 8(3): 557-568.
Dahme, T., J. Wood, et al. (2002). "Two different E2F6 proteins generated by alternative splicing and internal translation initiation." European Journal of Biochemistry 269(20): 5030-5036.
Darbinian, N., M. K. White, et al. (2006). "Regulation of the Pur-alpha promoter by E2F-1." J Cell Biochem 99(4): 1052-63.
Dasgupta, P., V. Betts, et al. (2004). "Direct Binding of Apoptosis Signal-regulating Kinase 1 to Retinoblastoma Protein: NOVEL LINKS BETWEEN APOPTOTIC SIGNALING AND CELL CYCLE MACHINERY." J. Biol. Chem. 279(37): 38762-38769.
Datta, A., A. Nag, et al. (2002). "Differential Regulation of E2F1, DP1, and the E2F1/DP1 Complex by ARF." Mol. Cell. Biol. 22(24): 8398-8408.
Datta, A., J. Sen, et al. (2005). "ARF Directly Binds DP1: Interaction with DP1 Coincides with the G1 Arrest Function of ARF." Mol. Cell. Biol. 25(18): 8024-8036.
Davis, J. N., M. T. McCabe, et al. (2005). "Disruption of Rb/E2F Pathway Results in Increased Cyclooxygenase-2 Expression and Activity in Prostate Epithelial Cells." Cancer Res 65(9): 3633-3642.
de Bruin, A., B. Maiti, et al. (2003). "Identification and Characterization of E2F7, a Novel Mammalian E2F Family Member Capable of Blocking Cellular Proliferation." J. Biol. Chem. 278(43): 42041-42049.
DeGregori, J. (2004). "The Rb network." J Cell Sci 117(16): 3411-3413.
DeGregori, J. and D. G. Johnson (2006). "Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis." Curr Mol Med 6(7): 739-48.
DeGregori, J., T. Kowalik, et al. (1995). "Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes [published erratum appears in Mol Cell Biol 1995 Oct;15(10):5846-7]." Mol. Cell. Biol. 15(8): 4215-4224.
Deng, C.-X. and S. G. Brodie (2000). "Roles of BRCA1 and its interacting proteins." BioEssays 22(8): 728-737.
Desai, D., H. C. Wessling, et al. (1995). "Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2." Mol. Cell. Biol. 15(1): 345-350.
Deschênes, C., L. Avarez, et al. (2004). "The nucleocytoplasmic shuttling of E2F4 is involved in the regulation of human intestinal epithelial cell proliferation and differentiation." Journal of Cellular Physiology 199(2): 262-273.
Devgan, V., C. Mammucari, et al. (2005). "p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation." Genes Dev. 19(12): 1485-1495.
Di Stefano, L., M. R. Jensen, et al. (2003). "E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes." Embo J 22(23): 6289-98.
Dick, F. A. and N. Dyson (2003). "pRB Contains an E2F1-Specific Binding Domain that Allows E2F1-Induced Apoptosis to Be Regulated Separately from Other E2F Activities." Molecular Cell 12(3): 639-649.
Diehl, J. A., F. Zindy, et al. (1997). "Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway." Genes Dev 11(8): 957-72.
Dimova, D. K. and N. J. Dyson (2005). "The E2F transcriptional network: old acquaintances with new faces." 24(17): 2810-2826.
Dimova, D. K., O. Stevaux, et al. (2003). "Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway." Genes Dev. 17(18): 2308-2320.
DuPree, E. L., S. Mazumder, et al. (2004). "Genotoxic Stress Induces Expression of E2F4, Leading to Its Association with p130 in Prostate Carcinoma Cells." Cancer Res 64(13): 4390-4393.
Ebelt, H., N. Hufnagel, et al. (2005). "Divergent Siblings: E2F2 and E2F4 but not E2F1 and E2F3 Induce DNA Synthesis in Cardiomyocytes Without Activation of Apoptosis." Circ Res 96(5): 509-517.
Eischen, C. M., G. Packham, et al. (2001). "Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1." Oncogene 20(48): 6983-93.
Fajas, L., R. L. Landsberg, et al. (2002). "E2Fs Regulate Adipocyte Differentiation." Developmental Cell 3(1): 39-49.
Fang, W., T. Mori, et al. (2002). "Regulation of PML-dependent transcriptional repression by pRB and low penetrance pRB mutants." Oncogene 21(36): 5557-65.
Farkas, T., K. Hansen, et al. (2002). "Distinct Phosphorylation Events Regulate p130- and p107-mediated Repression of E2F-4." J. Biol. Chem. 277(30): 26741-26752.
Fernandez de Mattos, S., E. W. Lam, et al. (2002). "An E2F-binding site mediates the activation of the proliferative isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by phosphatidylinositol 3-kinase." Biochem J 368(Pt 1): 283-91.
Ferreira, R., I. Naguibneva, et al. (2001). "Cell cycle-dependent recruitment of HDAC-1 correlates with deacetylation of histone H4 on an Rb-E2F target promoter." EMBO Rep 2(9): 794-9.
Ferreira, R., I. Naguibneva, et al. (2001). "The Rb/chromatin connection and epigenetic control: opinion." Oncogene 20(24): 3128-33.
Fogal, V., N. N. Kartasheva, et al. (2005). "ASPP1 and ASPP2 are new transcriptional targets of E2F." Cell Death Differ 12(4): 369-376.
Foray, N., D. Marot, et al. (2003). "A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein." Embo J 22(11): 2860-71.
Fortin, A., J. G. MacLaurin, et al. (2004). "The Proapoptotic Gene SIVA Is a Direct Transcriptional Target for the Tumor Suppressors p53 and E2F1." J. Biol. Chem. 279(27): 28706-28714.
Fox, E. J. and S. C. Wright (2003). "The transcriptional repressor gene Mad3 is a novel target for regulation by E2F1." Biochem J 370(Pt 1): 307-13.
Freedman, D. A. and A. J. Levine (1998). "Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6." Mol. Cell. Biol. 18(12): 7288-7293.
Friend, S., R. Bernards, et al. (1986). "A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma." Nature 323(6089): 643-6.
Frolov, M. V. and N. J. Dyson (2004). "Molecular mechanisms of E2F-dependent activation and pRB-mediated repression." J Cell Sci 117(11): 2173-2181.
Fuchs, S., V. Adler, et al. (1998). "Mdm2 association with p53 targets its ubiquitination." Oncogene 17(19): 2543-7.
Funahashi, A., N. Tanimura, et al. (2003). "CellDesigner: a process diagram editor for gene-regulatory and biochemical networks." 159-162.
Fung, T., C. Yam, et al. (2005 ). "The N-terminal regulatory domain of cyclin A contains redundant ubiquitination targeting sequences and acceptor sites." Cell Cycle 4(10): 1411-20.
Fung, T. K. and R. Y. C. Poon (2005). "A roller coaster ride with the mitotic cyclins." Seminars in Cell & Developmental Biology 16(3): 335-342.
Funke-Kaiser, H., F. Reichenberger, et al. (2003). "Differential binding of transcription factor E2F-2 to the endothelin-converting enzyme-1b promoter affects blood pressure regulation." Hum Mol Genet 12(4): 423-33.
Funke-Kaiser, H., A. Thomas, et al. (2003). "Regulation of the major isoform of human endothelin-converting enzyme-1 by a strong housekeeping promoter modulated by polymorphic microsatellites." J Hypertens 21(11): 2111-24.
Furukawa, Y., N. Nishimura, et al. (2002). "Apaf-1 Is a Mediator of E2F-1-induced Apoptosis." J. Biol. Chem. 277(42): 39760-39768.
Futreal, P. A., L. Coin, et al. (2004). "A census of human cancer genes." Nature Reviews Cancer 4(3): 177-183.
Gagneur, J. and S. Klamt (2004). "Computation of elementary modes: a unifying framework and the new binary approach." BMC Bioinformatics 5(1): 175.
Gagneur, J., R. Krause, et al. (2004). "Modular decomposition of protein-protein interaction networks." Genome Biology 5(8): R57.
Gagrica, S., S. Hauser, et al. (2004 ). "Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein." EMBO J. 23(23): 4627-38.
Galbiati, L., R. Mendoza-Maldonado, et al. (2005). "Regulation of E2F-1 after DNA damage by p300-mediated acetylation and ubiquitination." Cell Cycle 4(7): 930-9.
Gao, G., A. P. Bracken, et al. (2003). "NPAT Expression Is Regulated by E2F and Is Essential for Cell Cycle Progression." Mol. Cell. Biol. 23(8): 2821-2833.
Gartel, A. L., E. Goufman, et al. (1998). "Activation and repression of p21(WAF1/CIP1) transcription by RB binding proteins." Oncogene 17(26): 3463-9.
Gaubatz, S., J. A. Lees, et al. (2001). "E2F4 Is Exported from the Nucleus in a CRM1-Dependent Manner." Mol. Cell. Biol. 21(4): 1384-1392.
Gaubatz, S., G. J. Lindeman, et al. (2000). "E2F4 and E2F5 Play an Essential Role in Pocket Protein-Mediated G1 Control." Molecular Cell 6(3): 729-735.
Genovese, C., D. Trani, et al. (2006). "Cell cycle control and beyond: emerging roles for the retinoblastoma gene family." Oncogene 25(38): 5201-5209.
Gery, S., A. F. Gombart, et al. (2004). "C/EBP{epsilon} interacts with retinoblastoma and E2F1 during granulopoiesis." Blood 103(3): 828-835.
Giacinti, C. and A. Giordano (2006). "RB and cell cycle progression." Oncogene 25(38): 5220-5227.
Giangrande, P. H., T. C. Hallstrom, et al. (2003). "Identification of E-Box Factor TFE3 as a Functional Partner for the E2F3 Transcription Factor." Mol. Cell. Biol. 23(11): 3707-3720.
Giangrande, P. H., W. Zhu, et al. (2004). "Combinatorial gene control involving E2F and E Box family members." Embo J 23(6): 1336-47.
Giangrande, P. H., W. Zhu, et al. (2004). "A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription." Genes Dev. 18(23): 2941-2951.
Ginsberg, D. (2004). "E2F3--A Novel Repressor of the ARF/p53 Pathway." Developmental Cell 6(6): 742-743.
Gomez-Manzano, C., P. Mitlianga, et al. (2001). "Transfer of E2F-1 to Human Glioma Cells Results in Transcriptional Up-Regulation of Bcl-2." Cancer Res 61(18): 6693-6697.
Goto, Y., R. Hayashi, et al. (2006). "JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity." Biochim Biophys Acta 1759(1-2): 60-8.
Grafstrom, R. H., W. Pan, et al. (1999). "Defining the substrate specificity of cdk4 kinase–cyclin D1 complex." Carcinogenesis 20(2): 193-198.
Graves, P., C. Lovly, et al. (2001). "Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding." Oncogene 20(15): 1839-51.
Guan, K., C. Jenkins, et al. (1994). "Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function." Genes Dev. 8: 2939-52.
Guan, K., C. Jenkins, et al. (1996). "Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4." Mol Biol Cell 7(1): 57-70.
Gunawardena, R. W., H. Siddiqui, et al. (2004). "Hierarchical Requirement of SWI/SNF in Retinoblastoma Tumor Suppressor-mediated Repression of Plk1." J. Biol. Chem. 279(28): 29278-29285.
Hagting, A., M. Jackman, et al. (1999). "Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal." Current Biology 9(13): 680-689.
Hagting, A., C. Karlsson, et al. (1998). "MPF localization is controlled by nuclear export." Embo J 17(14): 4127-38.
Hannon, G. J. and D. Beach (1994). "pl5INK4B is a potentia| effector of TGF-[beta]-induced cell cycle arrest." Nature 371(6494): 257-261.
Hansen, K., T. Farkas, et al. (2001). "Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block." EMBO J. 20(3): 422-32.
Harris, S. L. and A. J. Levine (2005). "The p53 pathway: positive and negative feedback loops." Oncogene 24(17): 2899-2908.
Hayashi, R., Y. Goto, et al. (2006). "Comparative genomics on MCM8 orthologous genes reveals the transcriptional regulation by transcription factor E2F." Gene 367: 126-34.
Hayashi, R., Y. Goto, et al. (2006). "CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation." J Biol Chem 281(47): 35633-48.
He, Y. and W. D. Cress (2002). "E2F-3B Is a Physiological Target of Cyclin A." J. Biol. Chem. 277(26): 23493-23499.
Heald, R., M. McLoughlin, et al. (1993). "Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase." Cell 74(3): 463-474.
Hengst, L., U. Gopfert, et al. (1998). "Complete inhibition of Cdk/cyclin by one molecule of p21Cip1." Genes Dev. 12(24): 3882-3888.
Hershko, T., M. Chaussepied, et al. (2005). "Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F." Cell Death Differ 12(4): 377-383.
Hershko, T. and D. Ginsberg (2004). "Up-regulation of Bcl-2 Homology 3 (BH3)-only Proteins by E2F1 Mediates Apoptosis." J. Biol. Chem. 279(10): 8627-8634.
Hitchens, M. R. and P. D. Robbins (2003). "The role of the transcription factor DP in apoptosis." Apoptosis 8(5): 461-468.
Hlaing, M., P. Spitz, et al. (2004). "E2F-1 Regulates the Expression of a Subset of Target Genes during Skeletal Myoblast Hypertrophy." J. Biol. Chem. 279(42): 43625-43633.
Hofmann, F. and D. Livingston (1996). "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit." Genes Dev. 10(7): 851-61.
Honda, R., Y. Ohba, et al. (1993). "Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase." FEBS Letters 318(3): 331-334.
Honda, R., H. Tanaka, et al. (1997). "Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53." FEBS Letters 420(1): 25-27.
Huang, D., M. Jokela, et al. (2001). "E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase {{epsilon}} B-subunit gene POLE2." Nucl. Acids Res. 29(13): 2810-2821.
Huang, H., O. Zegarra-Moro, et al. (2004). "Androgens repress Bcl-2 expression via activation of the retinoblastoma (RB) protein in prostate cancer cells." Oncogene 23(12): 2161-76.
Hucka, M., A. Finney, et al. (2003). "The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models." Bioinformatics 19(4): 524-531.
Hughes, T. A. and H. J. M. Brady (2005). "Cross-talk between pRb/E2F and Wnt/[beta]-catenin pathways: E2F1 induces axin2 leading to repression of Wnt signalling and to increased cell death." Experimental Cell Research 303(1): 32-46.
Hughes, T. A. and H. J. M. Brady (2005). "E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation." Biochemical and Biophysical Research Communications 329(4): 1267-1274.
Humbert, P. O., R. Verona, et al. (2000). "E2f3 is critical for normal cellular proliferation." Genes Dev. 14(6): 690-703.
Ianari, A., R. Gallo, et al. (2004). "Specific Role for p300/CREB-binding Protein-associated Factor Activity in E2F1 Stabilization in Response to DNA Damage." J. Biol. Chem. 279(29): 30830-30835.
Ingenuity_Systems. "www.ingenuity.com."
Irwin, M., M. C. Marin, et al. (2000). "Role for the p53 homologue p73 in E2F-1-induced apoptosis." Nature 407(6804): 645-648.
Ishida, H., Y. Masuhiro, et al. (2005). "Identification and Characterization of Novel Isoforms of Human DP-1: DP-1{alpha} REGULATES THE TRANSCRIPTIONAL ACTIVITY OF E2F1 AS WELL AS CELL CYCLE PROGRESSION IN A DOMINANT-NEGATIVE MANNER." J. Biol. Chem. 280(26): 24642-24648.
Ishii, H., K. Mimori, et al. (2004). "Effect of exogenous E2F-1 on the expression of common chromosome fragile site genes, FHIT and WWOX." Biochemical and Biophysical Research Communications 316(4): 1088-1093.
Iwanaga, R., H. Komori, et al. (2006). "Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners." Oncogene 25(12): 1786-98.
Jackman, M., C. Lindon, et al. (2003). "Active cyclin B1-Cdk1 first appears on centrosomes in prophase." Nat Cell Biol 5(2): 143-148.
Jacobs, J. J. L. and M. van Lohuizen (2002). "Polycomb repression: from cellular memory to cellular proliferation and cancer." Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1602(2): 151-161.
Jhanwar-Uniyal, M. (2003). "BRCA1 in cancer, cell cycle and genomic stability." Front Biosci. 8: s1107-17.
Jiang, S. X., M. Sheldrick, et al. (2007). "Neuropilin-1 is a direct target of the transcription factor E2F1 during cerebral ischemia-induced neuronal death in vivo." Mol Cell Biol 27(5): 1696-705.
Jiang, Y., H. I. Saavedra, et al. (2004). "Aberrant Regulation of Survivin by the RB/E2F Family of Proteins." J. Biol. Chem. 279(39): 40511-40520.
Johnson, D. and R. Schneider-Broussard (1998). "Role of E2F in cell cycle control and cancer." Front Biosci. 3: d447-8.
Joshi-Tope, G., M. Gillespie, et al. (2005). "Reactome: a knowledgebase of biological pathways." Nucl. Acids Res. 33(suppl_1): D428-432.
Kaelin, W. J. (2003). " E2F1 as a target: promoter-driven suicide and small molecule modulators." Cancer Biol Ther. 2(4 Suppl 1): S48-54.
Kalma, Y., L. Marash, et al. (2001). "Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2." Oncogene 20(11): 1379-87.
Kamb, A. (1994). "A cell cycle regulator potentially involved in genesis of many tumor types." Science 264: 436-440.
Kanehisa, M. and S. Goto (2000). "KEGG: Kyoto Encyclopedia of Genes and Genomes." Nucl. Acids Res. 28(1): 27-30.
Katich, S., K. Zerfass-Thome, et al. (2001). "Regulation of the Cdc25A gene by the human papillomavirus Type 16 E7 oncogene." Oncogene 20(5): 543-50.
Kaye, F. (2002 ). " RB and cyclin dependent kinase pathways: defining a distinction between RB and p16 loss in lung cancer." Oncogene 21(45): 6908-14.
Khanna, K. K., K. E. Keating, et al. (1998). "ATM associates with and phosphorylates p53: mapping the region of interaction." Nat Genet 20(4): 398-400.
Kherrouche, Z., A. Blais, et al. (2006). "ASK-1 (apoptosis signal-regulating kinase 1) is a direct E2F target gene." Biochem J 396(3): 547-56.
Kikuchi, H., Y. Takami, et al. (2005). "GCN5: a supervisor in all-inclusive control of vertebrate cell cycle progression through transcription regulation of various cell cycle-related genes." Gene 347(1): 83-97.
Kim, J., A. A. Bhinge, et al. (2005). "Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment." Nat Meth 2(1): 47-53.
Kimura, M., C. Uchida, et al. (2004). "Cell cycle-dependent regulation of the human aurora B promoter." Biochemical and Biophysical Research Communications 316(3): 930-936.
Kishore, R., C. Luedemann, et al. (2003). "Tumor Necrosis Factor-Mediated E2F1 Suppression in Endothelial Cells: Differential Requirement of c-Jun N-Terminal Kinase and p38 Mitogen-Activated Protein Kinase Signal Transduction Pathways." Circ Res 93(10): 932-940.
Kitano, H., A. Funahashi, et al. (2005). "Using process diagrams for the graphical representation of biological networks." Nat Biotech 23(8): 961-966.
Klamt, S., J. Saez-Rodriguez, et al. (2006). "A methodology for the structural and functional analysis of signaling and regulatory networks." BMC Bioinformatics 7(1): 56.
Klipp, E., W. Liebermeister, et al. (2007). "Systems biology standards - the community speaks." Nat Biotech 25(4): 390-391.
Knudsen, E. S. and J. Y. Wang (1997). "Dual mechanisms for the inhibition of E2F binding to RB by cyclin- dependent kinase-mediated RB phosphorylation." Mol. Cell. Biol. 17(10): 5771-5783.
Knudson, A. J. (1971). "Mutation and cancer: statistical study of retinoblastoma." Proc Natl Acad Sci U S A 68(4).
Kohn, K. W. (1999). "Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems." Mol. Biol. Cell 10(8): 2703-2734.
Koziczak, M., H. Muller, et al. (2001). "E2F1-mediated transcriptional inhibition of the plasminogen activator inhibitor type 1 gene." European Journal of Biochemistry 268(18): 4969-4978.
Krull, M., S. Pistor, et al. (2006). "TRANSPATH: an information resource for storing and visualizing signaling pathways and their pathological aberrations." Nucl. Acids Res. 34(suppl_1): D546-551.
Krummenacker, M., S. Paley, et al. (2005). "Querying and computing with BioCyc databases." Bioinformatics 21(16): 3454-3455.
Kumagai, A. and W. G. Dunphy (2000). "Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts." Molecular Cell 6(4): 839-849.
Kuwako, K.-i., H. Taniura, et al. (2004). "Necdin-related MAGE Proteins Differentially Interact with the E2F1 Transcription Factor and the p75 Neurotrophin Receptor." J. Biol. Chem. 279(3): 1703-1712.
Kyrylenko, S., P. Korhonen, et al. (2000). "Expression of Transcriptional Repressor Proteins mSin3A and 3B during Aging and Replicative Senescence." Biochemical and Biophysical Research Communications 275(2): 455-459.
LaBaer, J., M. Garrett, et al. (1997). "New functional activities for the p21 family of CDK inhibitors." Genes Dev. 11(7): 847-62.
Lai, A., B. K. Kennedy, et al. (2001). "RBP1 Recruits the mSIN3-Histone Deacetylase Complex to the Pocket of Retinoblastoma Tumor Suppressor Family Proteins Found in Limited Discrete Regions of the Nucleus at Growth Arrest." Mol. Cell. Biol. 21(8): 2918-2932.
Lang, S. E., S. B. McMahon, et al. (2001). "E2F Transcriptional Activation Requires TRRAP and GCN5 Cofactors." J. Biol. Chem. 276(35): 32627-32634.
Larsen, C. (2004). "[pRB, p53, p16INK4a, senescence and malignant transformation]." Bull Cancer 91(5): 399-402.
Latres, E., M. Malumbres, et al. (2000). "Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis." EMBO J. 19(13): 3496-506.
Lavrrar, J. L. and P. J. Farnham (2004). "The Use of Transient Chromatin Immunoprecipitation Assays to Test Models for E2F1-specific Transcriptional Activation." J. Biol. Chem. 279(44): 46343-46349.
Le Novere, N., A. Finney, et al. (2005). "Minimum information requested in the annotation of biochemical models (MIRIAM)." Nat Biotech 23(12): 1509-1515.
Lee, J. H., B. Xu, et al. (2003). "Distinct Functions of Nijmegen Breakage Syndrome in Ataxia Telangiectasia Mutated-Dependent Responses to DNA Damage." Mol Cancer Res 1(9): 674-681.
Legewie, S., Bl, et al. (2006). "Mathematical Modeling Identifies Inhibitors of Apoptosis as Mediators of Positive Feedback and Bistability." PLoS Computational Biology 2(9): e120.
Leone, G., F. Nuckolls, et al. (2000). "Identification of a Novel E2F3 Product Suggests a Mechanism for Determining Specificity of Repression by Rb Proteins." Mol. Cell. Biol. 20(10): 3626-3632.
Li, Q., W.-M. Dashwood, et al. (2004). "Cloning of the rat [beta]-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters." Genomics 83(2): 231-242.
Li, Z., J. Stanelle, et al. (2005). "Selection of novel mediators of E2F1-induced apoptosis through retroviral expression of an antisense cDNA library." Nucl. Acids Res. 33(9): 2813-2821.
Liang, J. and J. Slingerland (2003). "Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression." Cell Cycle 2(4): 339-45.
Lin, W.-C., F.-T. Lin, et al. (2001). "Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation." Genes Dev. 15(14): 1833-1844.
Lindqvist, A., H. Kallstrom, et al. (2004). "Characterisation of Cdc25B localisation and nuclear export during the cell cycle and in response to stress." J Cell Sci 117(21): 4979-4990.
Litovchick, L., A. Chestukhin, et al. (2004). "Glycogen Synthase Kinase 3 Phosphorylates RBL2/p130 during Quiescence." Mol. Cell. Biol. 24(20): 8970-8980.
Liu, D. X., N. Nath, et al. (2005). "Regulation of neuron survival and death by p130 and associated chromatin modifiers." Genes Dev. 19(6): 719-732.
Liu, F. and W.-H. Lee (2006). "CtIP Activates Its Own and Cyclin D1 Promoters via the E2F/RB Pathway during G1/S Progression." Mol. Cell. Biol. 26(8): 3124-3134.
Liu, F., C. Rothblum-Oviatt, et al. (1999). "Overproduction of Human Myt1 Kinase Induces a G2 Cell Cycle Delay by Interfering with the Intracellular Trafficking of Cdc2-Cyclin B1 Complexes." Mol. Cell. Biol. 19(7): 5113-5123.
Liu, F., J. J. Stanton, et al. (1997). "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex." Mol. Cell. Biol. 17(2): 571-583.
Liu, H., C. Peng, et al. (2006). "Cloning and characterization of the BRD7 gene promoter." DNA Cell Biol 25(6): 346-58.
Liu, K., F.-T. Lin, et al. (2003). "Regulation of E2F1 by BRCT Domain-Containing Protein TopBP1." Mol. Cell. Biol. 23(9): 3287-3304.
Liu, K., Y. Luo, et al. (2004). "TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival." Genes Dev. 18(6): 673-686.
Liu, N., F. C. Lucibello, et al. (1996). "Cell cycle-regulated repression of B-myb transcription: cooperation of an E2F site with a contiguous corepressor element." Nucl. Acids Res. 24(15): 2905-2910.
Liu, Q., S. Guntuku, et al. (2000). "Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint." Genes Dev. 14(12): 1448-1459.
Logan, N., L. Delavaine, et al. (2004). "E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains." Oncogene 23(30): 5138-50.
Logan, N., A. Graham, et al. (2005). "E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7." Oncogene 24(31): 5000-5004.
Lu, Z., R. Z. Luo, et al. (2005). "E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer." Oncogene 25(2): 230-239.
Luciakova, K., P. Barath, et al. (2000). "Activity of the human cytochrome c1 promoter is modulated by E2F." Biochem J 351(Pt 1): 251-6.
Ludlow, J. W., C. L. Glendening, et al. (1993). "Specific enzymatic dephosphorylation of the retinoblastoma protein." Mol. Cell. Biol. 13(1): 367-372.
Lukas, C., C. S. Sorensen, et al. (1999). "Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex." Nature 401(6755): 815-818.
Lukas, J. and J. Bartek (2004). "Cell division: the heart of the cycle." Nature 432(7017): 564-7.
Lund, A. H. and M. van Lohuizen (2004). "Polycomb complexes and silencing mechanisms." Current Opinion in Cell Biology 16(3): 239-246.
Lyons, T. E., M. Salih, et al. (2006). "Activating E2Fs mediate transcriptional regulation of human E2F6 repressor." Am J Physiol Cell Physiol 290(1): C189-199.
Ma, Y., R. Croxton, et al. (2002). "Identification of Novel E2F1-Regulated Genes by Microarray." Archives of Biochemistry and Biophysics 399(2): 212-224.
Ma, Y., J. Yuan, et al. (2003). "Regulation of the Cyclin D3 Promoter by E2F1." J. Biol. Chem. 278(19): 16770-16776.
Macaluso, M., C. Cinti, et al. (2003). "pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer." Oncogene 22(23): 3511-7.
Magae, J., C. L. Wu, et al. (1996). "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members." J Cell Sci 109(7): 1717-1726.
Magnaghi-Jaulin, L., R. Groisman, et al. (1998). "Retinoblastoma protein represses transcription by recruiting a histone deacetylase." Nature 391(6667): 601-605.
Mailand, N., J. Falck, et al. (2000). "Rapid Destruction of Human Cdc25A in Response to DNA Damage." Science 288(5470): 1425-1429.
Mailand, N., A. Podtelejnikov, et al. (2002). "Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability." EMBO J. 21(21): 5911-20.
Maiti, B., J. Li, et al. (2005). "Cloning and Characterization of Mouse E2F8, a Novel Mammalian E2F Family Member Capable of Blocking Cellular Proliferation." J. Biol. Chem. 280(18): 18211-18220.
Malumbres, M., S. Ortega, et al. (2000). "Genetic analysis of mammalian cyclin-dependent kinases and their inhibitors." Biol Chem. 381(9-10): 827-38.
Marabese, M., F. Vikhanskaya, et al. (2003). "DNA damage induces transcriptional activation of p73 by removing C-EBP{alpha} repression on E2F1." Nucl. Acids Res. 31(22): 6624-6632.
Markey, M. P., S. P. Angus, et al. (2002). "Unbiased Analysis of RB-mediated Transcriptional Repression Identifies Novel Targets and Distinctions from E2F Action." Cancer Res 62(22): 6587-6597.
Martelli, F., T. Hamilton, et al. (2001). "p19ARF targets certain E2F species for degradation." PNAS 98(8): 4455-4460.
Marzio, G., C. Wagener, et al. (2000). "E2F Family Members Are Differentially Regulated by Reversible Acetylation." J. Biol. Chem. 275(15): 10887-10892.
Matsuoka, S., M. Huang, et al. (1998). "Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase." Science 282(5395): 1893-1897.
Matsuoka, S., G. Rotman, et al. (2000). "Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro." PNAS 97(19): 10389-10394.
Maya, R., M. Balass, et al. (2001). "ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage." Genes Dev. 15(9): 1067-1077.
McCabe, M. T., J. N. Davis, et al. (2005). "Regulation of DNA Methyltransferase 1 by the pRb/E2F1 Pathway." Cancer Res 65(9): 3624-3632.
Meloni, A. R., C.-H. Lai, et al. (2005). "A Mechanism of COOH-Terminal Binding Protein-Mediated Repression." Mol Cancer Res 3(10): 575-583.
Miard, S. and L. Fajas (2005). "Atypical transcriptional regulators and cofactors of PPAR[gamma]." Int J Obes Relat Metab Disord 29(S1): S10-S12.
Minella, A. and B. Clurman (2005 ). "Mechanisms of tumor suppression by the SCF(Fbw7)." Cell Cycle 4(10): 1356-9.
Minella, A. C., M. Welcker, et al. (2005). "Ras activity regulates cyclin E degradation by the Fbw7 pathway." PNAS 102(27): 9649-9654.
Morris, E. and N. Dyson (2001). "Retinoblastoma protein partners." Adv Cancer Res. 82: 1-54.
Morris, L., K. E. Allen, et al. (2000). "Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators." Nat Cell Biol 2(4): 232-239.
Morris, M. C., C. Gondeau, et al. (2002). "Kinetic Mechanism of Activation of the Cdk2/Cyclin A Complex. KEY ROLE OF THE C-LOBE OF THE Cdk." J. Biol. Chem. 277(26): 23847-23853.
Mousli, M., R. Hopfner, et al. (2003). " ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells." Br J Cancer 89(1): 120-7.
Mu, X. and C. Chang (2003). "TR3 Orphan Nuclear Receptor Mediates Apoptosis through Up-regulating E2F1 in Human Prostate Cancer LNCaP Cells." J. Biol. Chem. 278(44): 42840-42845.
Muchardt, C. and M. Yaniv (2001). "When the SWI/SNF complex remodels...the cell cycle." Oncogene 20(24): 3067-75.
Muller, H., A. P. Bracken, et al. (2001). "E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis." Genes Dev. 15(3): 267-285.
Muller-Weeks, S., R. J. Balzer, et al. (2005). "Proliferation-dependent expression of nuclear uracil-DNA glycosylase is mediated in part by E2F-4." DNA Repair 4(2): 183-190.
Murray, A. and T. Hunt (1994). The Cell Cycle: an introduction, Oxford University Press.
Nahle, Z., J. Polakoff, et al. (2002). "Direct coupling of the cell cycle and cell death machinery by E2F." Nat Cell Biol 4(11): 859-864.
Nevins, J. R. (2001). "The Rb/E2F pathway and cancer." Hum. Mol. Genet. 10(7): 699-703.
Nielsen, S. J., R. Schneider, et al. (2001). "Rb targets histone H3 methylation and HP1 to promoters." Nature 412(6846): 561-565.
Nowak, K., K. Kerl, et al. (2006). "BMI1 is a target gene of E2F-1 and is strongly expressed in primary neuroblastomas." Nucleic Acids Res 34(6): 1745-54.
Nowak, K., K. Killmer, et al. (2007). "E2F-1 regulates expression of FOXO1 and FOXO3a." Biochim Biophys Acta 1769(4): 244-52.
Oberley, M. J., D. R. Inman, et al. (2003). "E2F6 Negatively Regulates BRCA1 in Human Cancer Cells without Methylation of Histone H3 on Lysine 9." J. Biol. Chem. 278(43): 42466-42476.
Oda, K., T. Kimura, et al. (2004). "Molecular Interaction Map of a Macrophage." AFCS Research Reports 2.
Oda, K. and H. Kitano (2006). "A comprehensive map of the toll-like receptor signaling network." Mol Syst Biol 2.
Oda, K., Y. Matsuoka, et al. (2005). "A comprehensive pathway map of epidermal growth factor receptor signaling." Mol Syst Biol 1: E1-E17.
Ogawa, H., K.-i. Ishiguro, et al. (2002). "A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G0 Cells." Science 296(5570): 1132-1136.
Ohtani, K., J. DeGregori, et al. (1995). "Regulation of the Cyclin E Gene by Transcription Factor E2F1." PNAS 92(26): 12146-12150.
Ohtani, N., K. Yamakoshi, et al. (2004). "The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression." J Med Invest. 51(3-4): 146-53.
Orend, G., T. Hunter, et al. (1998). "Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells." Oncogene 16(20): 2575-83.
Ortega, S., M. Malumbres, et al. (2002). "Cyclin D-dependent kinases, INK4 inhibitors and cancer." Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1602(1): 73-87.
Parakati, R. and J. X. DiMario (2005). "Dynamic Transcriptional Regulatory Complexes, Including E2F4, p107, p130, and Sp1, Control Fibroblast Growth Factor Receptor 1 Gene Expression during Myogenesis." J. Biol. Chem. 280(22): 21284-21294.
Parakati, R. and J. X. DiMario (2005). "Repression of fibroblast growth factor receptor 1 gene expression by E2F4 in skeletal muscle cells." Developmental Dynamics 232(1): 119-130.
Parise, P., G. Finocchiaro, et al. (2006). "Lap2alpha expression is controlled by E2F and deregulated in various human tumors." Cell Cycle 5(12): 1331-41.
Parisi, T., A. Pollice, et al. (2002). "Transcriptional Regulation of the Human Tumor Suppressor p14ARF by E2F1, E2F2, E2F3, and Sp1-like Factors." Biochemical and Biophysical Research Communications 291(5): 1138-1145.
Parker, L. L. and H. Piwnica-Worms (1992). "Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase." Science 257(5078): 1955-1957.
Parker, L. L., S. A. Walter, et al. (1993). "Phosphorylation and inactivation of the mitotic inhibitor Weel by the nim1/cdr1 kinase." Nature 363(6431): 736-738.
Pediconi, N., A. Ianari, et al. (2003). "Differential regulation of E2F1 apoptotic target genes in response to DNA damage." Nat Cell Biol 5(6): 552-558.
Peng, C.-Y., P. R. Graves, et al. (1997). "Mitotic and G2 Checkpoint Control: Regulation of 14-3-3?Protein Binding by Phosphorylation of Cdc25C on Serine-216." Science 277(5331): 1501-1505.
Phillips, A. C., M. K. Ernst, et al. (1999). "E2F-1 Potentiates Cell Death by Blocking Antiapoptotic Signaling Pathways." Molecular Cell 4(5): 771-781.
Pines, J. and T. Hunter (1991). "Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport." J. Cell Biol. 115(1): 1-17.
Pines, J. and T. Hunter (1994). "The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B." EMBO J. 13(16): 3772-81.
Planas-Silva, M. D. and R. A. Weinberg (1997). "The restriction point and control of cell proliferation." Current Opinion in Cell Biology 9(6): 768-772.
Plessner, H. L., P. L. Lin, et al. (2007). "Neutralization of Tumor Necrosis Factor (TNF) by Antibody but not TNF Receptor Fusion Molecule Exacerbates Chronic Murine Tuberculosis." J Infect Dis 195(11): 1643-50.
Pohlers, M., M. Truss, et al. (2005). "A Role for E2F6 in the Restriction of Male-Germ-Cell-Specific Gene Expression." Current Biology 15(11): 1051-1057.
Polager, S. and D. Ginsberg (2003). "E2F Mediates Sustained G2 Arrest and Down-regulation of Stathmin and AIM-1 Expression in Response to Genotoxic Stress." J. Biol. Chem. 278(3): 1443-1449.
Polager, S., Y. Kalma, et al. ( 2002 ). "E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis." Oncogene 21(3): 437-46.
Powers, J. T., S. Hong, et al. (2004). "E2F1 Uses the ATM Signaling Pathway to Induce p53 and Chk2 Phosphorylation and Apoptosis." Mol Cancer Res 2(4): 203-214.
Putowski, L., W. Gasior, et al. (2001). "[Differences in human and rat FSH receptors promote activity as a result of the transcriptional factors: E2F1, E2F4 and E2F5 overexpression]." Ginekol Pol 72(12A): 1560-6.
Rape, M. and M. W. Kirschner (2004). "Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry." Nature 432(7017): 588-595.
Rayman, J. B., Y. Takahashi, et al. (2002). "E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex." Genes Dev. 16(8): 933-947.
Ren, B., H. Cam, et al. (2002). "E2F integrates cell cycle progression with DNA repair, replication, and G2/M checkpoints." Genes Dev. 16(2): 245-256.
Ren, S. and B. J. Rollins (2004). "Cyclin C/Cdk3 Promotes Rb-Dependent G0 Exit." Cell 117(2): 239-251.
Rogoff, H. A., M. T. Pickering, et al. (2004). "Apoptosis Associated with Deregulated E2F Activity Is Dependent on E2F1 and Atm/Nbs1/Chk2." Mol. Cell. Biol. 24(7): 2968-2977.
Roussel, M. (1999). "The INK4 family of cell cycle inhibitors in cancer." Oncogene 18(38): 5311-7.
Sage, J. (2004). "Cyclin C Makes an Entry into the Cell Cycle." Developmental Cell 6(5): 607-608.
Sakchaisri, K., S. Asano, et al. (2004). "Coupling morphogenesis to mitotic entry." PNAS 101(12): 4124-4129.
Sala, A., N. C. Nicolaides, et al. (1994). "Correlation between E2F-1 Requirement in the S Phase and E2F-1 Transactivation of Cell Cycle-related Genes in Human Cells." Cancer Res 54(6): 1402-1406.
Salomoni, P. and P. P. Pandolfi (2002). "The Role of PML in Tumor Suppression." Cell 108(2): 165-170.
Sanchez, I. and B. D. Dynlacht (2005). "New insights into cyclins, CDKs, and cell cycle control." Seminars in Cell & Developmental Biology 16(3): 311-321.
Sánchez-Beato, M., E. Sánchez, et al. (2004). "Abnormal PcG protein expression in Hodgkin's lymphoma. Relation with E2F6 and NF?B transcription factors." The Journal of Pathology 204(5): 528-537.
Seelan, R. S., L. K. Parthasarathy, et al. (2004). "E2F1 regulation of the human myo-inositol 1-phosphate synthase (ISYNA1) gene promoter." Archives of Biochemistry and Biophysics 431(1): 95-106.
Semizarov, D., P. Kroeger, et al. (2004). "siRNA-mediated gene silencing: a global genome view." Nucl. Acids Res. 32(13): 3836-3845.
Serrano, M., G. J. Hannon, et al. (1993). "A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4." Nature 366(6456): 704-707.
Shannon, P., A. Markiel, et al. (2003). "Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks." Genome Res. 13(11): 2498-2504.
Sherr, C. J. and F. McCormick (2002). "The RB and p53 pathways in cancer." Cancer Cell 2(2): 103-112.
Sherr, C. J. and J. M. Roberts (1999). "CDK inhibitors: positive and negative regulators of G1-phase progression." Genes Dev. 13(12): 1501-1512.
Slansky, J. E., Y. Li, et al. (1993). "A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter." Mol. Cell. Biol. 13(3): 1610-1618.
Sorensen, C., R. Syljuasen, et al. (2004). " ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage." Cell Cycle 3(7): 941-5.
Stanelle, J., T. Stiewe, et al. (2002). "Gene expression changes in response to E2F1 activation." Nucl. Acids Res. 30(8): 1859-1867.
Stevaux, O. and N. J. Dyson (2002). "A revised picture of the E2F transcriptional network and RB function." Current Opinion in Cell Biology 14(6): 684-691.
Stevens, C., L. Smith, et al. (2003). "Chk2 activates E2F-1 in response to DNA damage." Nat Cell Biol 5(5): 401-409.
Stone, S., P. Jiang, et al. (1995). "Complex Structure and Regulation of the P16 (MTS1) Locus." Cancer Res 55(14): 2988-2994.
Storre, J., H. Elsasser, et al. (2002). "Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6." EMBO Rep. 3(7): 695-700.
Strausfeld, U., A. Fernandez, et al. (1994). "Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis." J. Biol. Chem. 269(8): 5989-6000.
Strausfeld, U., J. C. Labbe, et al. (1991). "Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein." Nature 351(6323): 242-245.
Strieder, V. and W. Lutz (2003). "E2F Proteins Regulate MYCN Expression in Neuroblastomas." J. Biol. Chem. 278(5): 2983-2989.
Tabin, C. J. (1982). "Mechanism of activation of a human oncogene." Nature 300: 143-149.
Takahashi, Y., J. B. Rayman, et al. (2000). "Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression." Genes Dev. 14(7): 804-816.
Takai, H., K. Tominaga, et al. (2000). "Aberrant cell cycle checkpoint function and early embryonic death in Chk1-/- mice." Genes Dev. 14(12): 1439-1447.
Takizawa, C. G. and D. O. Morgan (2000). "Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C." Current Opinion in Cell Biology 12(6): 658-665.
Tannapfel, A., F. Sommerer, et al. (2002). "Genetic and epigenetic alterations of the INK4a-ARF pathway in cholangiocarcinoma." The Journal of Pathology 197(5): 624-631.
Tashiro, E., H. Maruki, et al. (2003). "Overexpression of Cyclin D1 Contributes to Malignancy by Up-Regulation of Fibroblast Growth Factor Receptor 1 via the pRB/E2F Pathway." Cancer Res 63(2): 424-431.
Tashiro, E., Y. Minato, et al. (2003). "Regulation of FGF receptor-2 expression by transcription factor E2F-1." Oncogene 22(36): 5630-5.
Taubert, S., C. Gorrini, et al. (2004). "E2F-Dependent Histone Acetylation and Recruitment of the Tip60 Acetyltransferase Complex to Chromatin in Late G1." Mol. Cell. Biol. 24(10): 4546-4556.
Tedesco, D., J. Lukas, et al. (2002). "The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2." Genes Dev. 16(22): 2946-2957.
Thierry, F., M. A. Benotmane, et al. (2004). "A Genomic Approach Reveals a Novel Mitotic Pathway in Papillomavirus Carcinogenesis." Cancer Res 64(3): 895-903.
Thomas, P. D., M. J. Campbell, et al. (2003). "PANTHER: A Library of Protein Families and Subfamilies Indexed by Function." Genome Res. 13(9): 2129-2141.
Toyoshima-Morimoto, F., E. Taniguchi, et al. (2002). "Plk1 promotes nuclear translocation of human Cdc25C during prophase." EMBO Rep. 3(4): 341-8.
Trimarchi, J. M., B. Fairchild, et al. (2001). "The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex." PNAS 98(4): 1519-1524.
Tsantoulis, P. K. and V. G. Gorgoulis (2005). "Involvement of E2F transcription factor family in cancer." European Journal of Cancer 41(16): 2403-2414.
Tseng, Y.-H., A. J. Butte, et al. (2005). "Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin." Nat Cell Biol 7(6): 601-611.
Unoki, M., T. Nishidate, et al. (2004 ). " ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain." Oncogene 23(46): 7601-10.
Uto, K., D. Inoue, et al. (2004). "Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism." EMBO J. 23(16): 3386-96.
Vakoc, C. R., S. A. Mandat, et al. (2005). "Histone H3 Lysine 9 Methylation and HP1[gamma] Are Associated with Transcription Elongation through Mammalian Chromatin." Molecular Cell 19(3): 381-391.
Valk-Lingbeek, M. E., S. W. M. Bruggeman, et al. (2004). "Stem Cells and Cancer: The Polycomb Connection." Cell 118(4): 409-418.
Vandel, L., E. Nicolas, et al. (2001). "Transcriptional Repression by the Retinoblastoma Protein through the Recruitment of a Histone Methyltransferase." Mol. Cell. Biol. 21(19): 6484-6494.
Verlinden, L., G. Eelen, et al. (2005). "Characterization of the condensin component Cnap1 and protein kinase Melk as novel E2F target genes down-regulated by 1,25-dihydroxyvitamin D3." J Biol Chem 280(45): 37319-30.
Vermeulen, K., D. R. Van Bockstaele, et al. (2003). "The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer." Cell Proliferation 36(3): 131-149.
Vernell, R., K. Helin, et al. (2003). "Identification of Target Genes of the p16INK4A-pRB-E2F Pathway." J. Biol. Chem. 278(46): 46124-46137.
Verona, R., K. Moberg, et al. (1997). "E2F activity is regulated by cell cycle-dependent changes in subcellular localization." Mol. Cell. Biol. 17(12): 7268-7282.
Viallard, J. F., F. Lacombe, et al. (2001). "Mecanismes moleculaires controlant le cycle cellulaire : aspects fondamentaux et implications en cancerologieMolecular mechanisms controling the cell cycle: main considerations and implications in oncology." Cancer/Radiotherapie 5(2): 109-129.
Vidal, A. and A. Koff (2000). "Cell-cycle inhibitors: three families united by a common cause." Gene 247(1-2): 1-15.
Vorburger, S., A. Pataer, et al. (2002). "Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis." Oncogene 21(41): 6278-88.
Vorburger, S. A., N. Hetrakul, et al. (2005). "Gene therapy with E2F-1 up-regulates the protein kinase PKR and inhibits growth of leiomyosarcoma in vivo." Mol Cancer Ther 4(11): 1710-1716.
Wang, B., K. Liu, et al. (2004). "A Role for 14-3-3{tau} in E2F1 Stabilization and DNA Damage-induced Apoptosis." J. Biol. Chem. 279(52): 54140-54152.
Wang, C., X. Hou, et al. (2005). "Activation of p27Kip1 Expression by E2F1: A NEGATIVE FEEDBACK MECHANISM." J. Biol. Chem. 280(13): 12339-12343.
Wang, G.-L., P. Iakova, et al. (2004). "Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP{alpha} growth inhibitory activity." Genes Dev. 18(8): 912-925.
Wang, H., N. Shao, et al. (1997). "BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases." Oncogene 15(2): 143-57.
Watanabe, N., H. Arai, et al. (2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCF{beta}-TrCP." PNAS 101(13): 4419-4424.
Watanabe, N., H. Arai, et al. (2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCF{beta}-TrCP." PNAS 101(13): 4419-4424.
Weinberg, R. A. (1995). "The retinoblastoma protein and cell cycle control." Cell 81(3): 323-330.
Weinmann, A. S., S. M. Bartley, et al. (2001). "Use of Chromatin Immunoprecipitation To Clone Novel E2F Target Promoters." Mol. Cell. Biol. 21(20): 6820-6832.
Weinmann, A. S., P. S. Yan, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis." Genes Dev. 16(2): 235-244.
Wells, J., C. R. Graveel, et al. (2002). "The identification of E2F1-specific target genes." PNAS 99(6): 3890-3895.
Williamson, E., G. Burgess, et al. (1997). "Cyclic AMP negatively controls c-myc transcription and G1 cell cycle progression in p210 BCR-ABL transformed cells: inhibitory activity exerted through cyclin D1 and cdk4." Leukemia 11(1): 73-85.
Wolfe, B. and K. Gould (2004). " Inactivating Cdc25, mitotic style." Cell Cycle 3(5): 601-3.
Won, J., J. Yim, et al. (2002). "Opposing regulatory roles of E2F in human telomerase reverse transcriptase (hTERT) gene expression in human tumor and normal somatic cells." FASEB J.: 02-0311fje.
Won, K. and S. Reed (1996). "Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E." EMBO J. 15(16): 4182-93.
Woods, K., J. M. Thomson, et al. (2007). "Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors." J Biol Chem 282(4): 2130-4.
Wu, J., Y. J. Jin, et al. (2007). "PAC1 is a direct transcription target of E2F-1 in apoptotic signaling." Oncogene.
Yamada, M., N. Sato, et al. (2002). "A 63-Base Pair DNA Segment Containing an Sp1 Site but Not a Canonical E2F Site Can Confer Growth-dependent and E2F-mediated Transcriptional Stimulation of the Human ASK Gene Encoding the Regulatory Subunit for Human Cdc7-related Kinase." J. Biol. Chem. 277(31): 27668-27681.
Yang, J., E. S. G. Bardes, et al. (1998). "Control of Cyclin B1 localization through regulated binding of the nuclear export factor CRM1." Genes Dev. 12(14): 2131-2143.
Yoshida, K. and I. Inoue (2004). "Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor." Oncogene 23(37): 6250-60.
Yoshida, K. and I. Inoue (2004). "Regulation of Geminin and Cdt1 expression by E2F transcription factors." Oncogene 23(21): 3802-12.
Yu, Z.-K., J. L. M. Gervais, et al. (1998). "Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21CIP1/WAF1 and cyclin D proteins." PNAS 95(19): 11324-11329.
Zhang, H. S., M. Gavin, et al. (2000). "Exit from G1 and S Phase of the Cell Cycle Is Regulated by Repressor Complexes Containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF." Cell 101(1): 79-89.
Zhang, L. and C. Wang (2006). "F-box protein Skp2: a novel transcriptional target of E2F." Oncogene 25(18): 2615-27.
Zhang, Y. and S. Chellappan (1995). "Cloning and characterization of human DP2, a novel dimerization partner of E2F." Oncogene 10(11): 2085-93.
Zhao, H. and H. Piwnica-Worms (2001). "ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1." Mol. Cell. Biol. 21(13): 4129-4139.
Zhou, B. P., Y. Liao, et al. (2001). "Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells." Nat Cell Biol 3(3): 245-252.
Zhou, D., S. Masri, et al. (2005). "Transcriptional regulation of the mouse PNRC2 promoter by the nuclear factor Y (NFY) and E2F1." Gene 361: 89-100.
Zhu, W., P. Giangrande, et al. (2004). "E2Fs link the control of G1/S and G2/M transcription." EMBO J. 23(23): 4615-26.
Ziebold, U., T. Reza, et al. (2001). "E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos." Genes Dev. 15(4): 386-391.
