(center map)
(1) gPMAIP1@nucleus - active~TP53@nucleus - active~HIF1@nucleus - active~FOXO@nucleus - CTBP*@nucleus - active~E2F1@nucleus --> rPMAIP1@nucleus
(2) gBBC3@nucleus - active~TP53@nucleus - TP73@nucleus - active~E2F1@nucleus --> rBBC3@nucleus
(3) gBID@nucleus - active~TP53@nucleus - active~HIF1@nucleus - active~E2F1@nucleus --> rBID@nucleus
(4) gAPAF1@nucleus - active~TP53@nucleus - active~E2F1@nucleus --> rAPAF1@nucleus
(5) gMR17HG@nucleus - active~TP53@nucleus - active~E2F1@nucleus - active~MYC@nucleus --> arMIR17HG@nucleus
(6) rE2F1@nucleus - arMIR17 - arMIR20A -> active~E2F1@nucleus
(7) gMCM7@nucleus - active~E2F1@nucleus --> rpre-mRNA~MCM7@nucleus
(8) gBCL2L11@nucleus - active~NF_kappa_B2@nucleus - active~FOXO@nucleus - active~E2F1@nucleus --> rBCL2L11@nucleus
(9) gSIVA1@nucleus - active~TP53@nucleus - active~E2F1@nucleus --> rSIVA1@nucleus
(10) gCASP8@nucleus - active~E2F1@nucleus - active~MYC@nucleus --> rCASP8@nucleus
(11) gHRK@nucleus - active~E2F1@nucleus - KCNIP3@nucleus --> rHRK@nucleus
(12) gCASP7@nucleus - active~E2F1@nucleus --> rCASP7@nucleus
(13) gCASP3@nucleus - active~E2F1@nucleus --> rCASP3@nucleus
(14) gCASP9@nucleus - active~E2F1@nucleus --> rCASP9@nucleus
(15) cell cycle~arrest@nucleus - active~E2F1@nucleus - ANAPC1:ANAPC10:ANAPC11:ANAPC13:ANAPC2:ANAPC4:ANAPC5:ANAPC7:CDC16:CDC23:CDC26:CDC27:FZR1@nucleus -> cell cycle~progression@nucleus
(16) gCDC20B@nucleus - active~E2F1@nucleus --> rpre-mRNA~CDC20B@nucleus
(17) active~E2F1@nucleus - CDKN1A - CDK6@nucleus - RB1@nucleus -> inactive~E2F1@nucleus
(18) inactive~E2F1@nucleus - CDKN1B@nucleus -> active~E2F1@nucleus