(center map) (center map)PMID:18328430 MIR17HG transactivation by E2F1 PMID:15944709 MIR17-92 cluster transactivation by MYC PMID:19696742 MIR17HG transactivation repressed by TP53. Proposed mechanism TP53- and TBP- binding sites overlaps. in human colorectal carcinoma HCT116 (TP53 competent cells), MIR17HG repression upon hypoxia and TP53 stabilization. in human colorectal carcinoma cells HCT116 and LOVO, this effect is blocked by siRNA against TP53 in HCT116 and LOVO, siRNA against MYC represses MIR17-92 expression