Toppgene analysis for aggregated_1964_log, IC9, positive side

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1: GO: Molecular Function [Display Chart] 554 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004386 helicase activity 3.109E-15 1.722E-12 1.188E-11 1.722E-12 22 172
2 GO:0016887 ATPase activity 1.013E-12 2.806E-10 1.935E-9 5.612E-10 30 446
3 GO:0008026 ATP-dependent helicase activity 4.513E-11 6.251E-9 4.310E-8 2.500E-8 15 112
4 GO:0070035 purine NTP-dependent helicase activity 4.513E-11 6.251E-9 4.310E-8 2.500E-8 15 112
5 GO:0042623 ATPase activity, coupled 1.651E-9 1.829E-7 1.261E-6 9.144E-7 22 332
6 GO:0003729 mRNA binding 4.807E-9 4.439E-7 3.061E-6 2.663E-6 16 180
7 GO:0008094 DNA-dependent ATPase activity 6.321E-9 5.003E-7 3.450E-6 3.502E-6 12 93
8 GO:0004004 ATP-dependent RNA helicase activity 2.451E-8 1.508E-6 1.040E-5 1.358E-5 10 66
9 GO:0008186 RNA-dependent ATPase activity 2.451E-8 1.508E-6 1.040E-5 1.358E-5 10 66
10 GO:0042393 histone binding 3.778E-8 2.093E-6 1.443E-5 2.093E-5 15 181
11 GO:0003724 RNA helicase activity 8.626E-8 4.344E-6 2.996E-5 4.779E-5 10 75
12 GO:0070577 lysine-acetylated histone binding 2.717E-6 1.254E-4 8.649E-4 1.505E-3 5 17
13 GO:0001047 core promoter binding 3.533E-6 1.506E-4 1.038E-3 1.957E-3 12 165
14 GO:0003730 mRNA 3'-UTR binding 7.334E-6 2.902E-4 2.001E-3 4.063E-3 7 52
15 GO:0016874 ligase activity 2.239E-5 8.270E-4 5.703E-3 1.241E-2 18 415
16 GO:0003714 transcription corepressor activity 2.825E-5 8.850E-4 6.102E-3 1.565E-2 13 236
17 GO:0003678 DNA helicase activity 3.272E-5 8.850E-4 6.102E-3 1.813E-2 7 65
18 GO:0070735 protein-glycine ligase activity 3.994E-5 8.850E-4 6.102E-3 2.212E-2 13 244
19 GO:0070738 tubulin-glycine ligase activity 3.994E-5 8.850E-4 6.102E-3 2.212E-2 13 244
20 GO:0070736 protein-glycine ligase activity, initiating 3.994E-5 8.850E-4 6.102E-3 2.212E-2 13 244
21 GO:0070737 protein-glycine ligase activity, elongating 3.994E-5 8.850E-4 6.102E-3 2.212E-2 13 244
22 GO:0043774 coenzyme F420-2 alpha-glutamyl ligase activity 3.994E-5 8.850E-4 6.102E-3 2.212E-2 13 244
23 GO:0008766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity 3.994E-5 8.850E-4 6.102E-3 2.212E-2 13 244
24 GO:0043773 coenzyme F420-0 gamma-glutamyl ligase activity 3.994E-5 8.850E-4 6.102E-3 2.212E-2 13 244
25 GO:0018169 ribosomal S6-glutamic acid ligase activity 3.994E-5 8.850E-4 6.102E-3 2.212E-2 13 244
26 GO:0070740 tubulin-glutamic acid ligase activity 4.530E-5 9.652E-4 6.655E-3 2.510E-2 13 247
27 GO:0070739 protein-glutamic acid ligase activity 4.921E-5 1.010E-3 6.963E-3 2.726E-2 13 249
28 GO:0046966 thyroid hormone receptor binding 6.361E-5 1.259E-3 8.678E-3 3.524E-2 5 31
29 GO:0016879 ligase activity, forming carbon-nitrogen bonds 7.133E-5 1.358E-3 9.363E-3 3.952E-2 14 295
30 GO:0016881 acid-amino acid ligase activity 7.353E-5 1.358E-3 9.363E-3 4.074E-2 13 259
31 GO:0035064 methylated histone binding 1.014E-4 1.813E-3 1.250E-2
5.620E-2
 6 54
32 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding 1.710E-4 2.914E-3 2.009E-2
9.472E-2
 9 142
33 GO:0008536 Ran GTPase binding 1.736E-4 2.914E-3 2.009E-2
9.615E-2
 5 38
34 GO:0001046 core promoter sequence-specific DNA binding 2.078E-4 3.383E-3 2.332E-2
1.151E-1
 8 115
35 GO:0008017 microtubule binding 2.137E-4 3.383E-3 2.332E-2
1.184E-1
 11 214
36 GO:0047485 protein N-terminus binding 2.480E-4 3.817E-3 2.632E-2
1.374E-1
 8 118
37 GO:0003725 double-stranded RNA binding 3.655E-4 5.473E-3 3.774E-2
2.025E-1
 6 68
38 GO:0001104 RNA polymerase II transcription cofactor activity 3.887E-4 5.666E-3 3.907E-2
2.153E-1
 7 96
39 GO:0051010 microtubule plus-end binding 4.052E-4 5.756E-3 3.969E-2
2.245E-1
 3 11
40 GO:0035257 nuclear hormone receptor binding 4.346E-4 6.020E-3 4.151E-2
2.408E-1
 9 161
41 GO:0004003 ATP-dependent DNA helicase activity 4.790E-4 6.472E-3 4.463E-2
2.654E-1
 5 47
42 GO:0003743 translation initiation factor activity 7.011E-4 9.248E-3
6.377E-2
3.884E-1
 5 51
43 GO:0001221 transcription cofactor binding 7.567E-4 9.749E-3
6.722E-2
4.192E-1
 4 30
44 GO:0015631 tubulin binding 8.697E-4 1.095E-2
7.550E-2
4.818E-1
 12 293
45 GO:0051427 hormone receptor binding 1.130E-3 1.347E-2
9.291E-2
6.258E-1
 9 184
46 GO:0036033 mediator complex binding 1.137E-3 1.347E-2
9.291E-2
6.301E-1
 2 4
47 GO:0042826 histone deacetylase binding 1.143E-3 1.347E-2
9.291E-2
6.333E-1
 7 115
48 GO:0001085 RNA polymerase II transcription factor binding 1.328E-3 1.533E-2
1.057E-1
7.358E-1
 7 118
49 GO:0019787 ubiquitin-like protein transferase activity 1.379E-3 1.559E-2
1.075E-1
7.637E-1
 15 441
50 GO:0001102 RNA polymerase II activating transcription factor binding 1.868E-3 2.032E-2
1.401E-1
1.000E0
 4 38
Show 45 more annotations

2: GO: Biological Process [Display Chart] 3359 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006397 mRNA processing 5.359E-21 9.047E-18 7.868E-17 1.800E-17 41 480
2 GO:0008380 RNA splicing 5.387E-21 9.047E-18 7.868E-17 1.809E-17 38 403
3 GO:0000375 RNA splicing, via transesterification reactions 4.679E-17 5.239E-14 4.556E-13 1.572E-13 30 310
4 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 2.817E-16 1.892E-13 1.646E-12 9.461E-13 29 306
5 GO:0000398 mRNA splicing, via spliceosome 2.817E-16 1.892E-13 1.646E-12 9.461E-13 29 306
6 GO:0010608 posttranscriptional regulation of gene expression 1.448E-13 8.105E-11 7.048E-10 4.863E-10 32 478
7 GO:0006417 regulation of translation 2.928E-12 1.405E-9 1.222E-8 9.837E-9 26 349
8 GO:0034248 regulation of cellular amide metabolic process 3.746E-12 1.573E-9 1.368E-8 1.258E-8 27 382
9 GO:0017148 negative regulation of translation 1.700E-10 6.345E-8 5.518E-7 5.711E-7 16 145
10 GO:0034249 negative regulation of cellular amide metabolic process 4.203E-10 1.412E-7 1.228E-6 1.412E-6 16 154
11 GO:0022618 ribonucleoprotein complex assembly 6.768E-10 2.067E-7 1.797E-6 2.273E-6 18 208
12 GO:0071826 ribonucleoprotein complex subunit organization 1.445E-9 4.044E-7 3.517E-6 4.853E-6 18 218
13 GO:0033044 regulation of chromosome organization 1.568E-9 4.052E-7 3.524E-6 5.267E-6 21 304
14 GO:0022613 ribonucleoprotein complex biogenesis 1.810E-9 4.342E-7 3.776E-6 6.079E-6 26 468
15 GO:0071103 DNA conformation change 2.975E-9 6.661E-7 5.793E-6 9.991E-6 20 285
16 GO:0007059 chromosome segregation 8.359E-9 1.755E-6 1.526E-5 2.808E-5 21 334
17 GO:1903311 regulation of mRNA metabolic process 3.300E-8 6.163E-6 5.360E-5 1.108E-4 13 131
18 GO:0018205 peptidyl-lysine modification 3.302E-8 6.163E-6 5.360E-5 1.109E-4 23 430
19 GO:0040029 regulation of gene expression, epigenetic 3.692E-8 6.528E-6 5.677E-5 1.240E-4 18 268
20 GO:0043484 regulation of RNA splicing 4.308E-8 7.236E-6 6.293E-5 1.447E-4 12 111
21 GO:0006338 chromatin remodeling 7.153E-8 1.115E-5 9.699E-5 2.403E-4 14 165
22 GO:0016925 protein sumoylation 7.304E-8 1.115E-5 9.699E-5 2.454E-4 13 140
23 GO:0000245 spliceosomal complex assembly 7.914E-8 1.156E-5 1.005E-4 2.658E-4 9 57
24 GO:0016570 histone modification 8.519E-8 1.192E-5 1.037E-4 2.861E-4 23 453
25 GO:0000819 sister chromatid segregation 9.846E-8 1.323E-5 1.150E-4 3.307E-4 16 225
26 GO:0016441 posttranscriptional gene silencing 1.079E-7 1.343E-5 1.168E-4 3.625E-4 9 59
27 GO:0035194 posttranscriptional gene silencing by RNA 1.079E-7 1.343E-5 1.168E-4 3.625E-4 9 59
28 GO:0016569 covalent chromatin modification 1.527E-7 1.832E-5 1.594E-4 5.131E-4 23 468
29 GO:0010501 RNA secondary structure unwinding 1.626E-7 1.883E-5 1.637E-4 5.460E-4 8 45
30 GO:0019827 stem cell population maintenance 1.841E-7 2.061E-5 1.792E-4 6.183E-4 14 178
31 GO:0007062 sister chromatid cohesion 1.933E-7 2.095E-5 1.822E-4 6.493E-4 12 127
32 GO:0098727 maintenance of cell number 2.262E-7 2.375E-5 2.065E-4 7.599E-4 14 181
33 GO:0000380 alternative mRNA splicing, via spliceosome 3.243E-7 3.301E-5 2.871E-4 1.089E-3 8 49
34 GO:0051168 nuclear export 3.603E-7 3.559E-5 3.095E-4 1.210E-3 14 188
35 GO:0098813 nuclear chromosome segregation 4.375E-7 4.199E-5 3.652E-4 1.470E-3 17 283
36 GO:0000226 microtubule cytoskeleton organization 5.478E-7 5.112E-5 4.445E-4 1.840E-3 22 465
37 GO:0006302 double-strand break repair 5.978E-7 5.427E-5 4.720E-4 2.008E-3 14 196
38 GO:2001251 negative regulation of chromosome organization 7.852E-7 6.941E-5 6.036E-4 2.638E-3 11 119
39 GO:0032508 DNA duplex unwinding 9.978E-7 8.594E-5 7.474E-4 3.352E-3 9 76
40 GO:0051236 establishment of RNA localization 1.518E-6 1.275E-4 1.108E-3 5.098E-3 13 182
41 GO:0032392 DNA geometric change 1.721E-6 1.410E-4 1.226E-3 5.780E-3 9 81
42 GO:2001252 positive regulation of chromosome organization 1.899E-6 1.519E-4 1.321E-3 6.378E-3 12 157
43 GO:0031047 gene silencing by RNA 2.169E-6 1.695E-4 1.474E-3 7.287E-3 12 159
44 GO:0051983 regulation of chromosome segregation 3.149E-6 2.404E-4 2.090E-3 1.058E-2 9 87
45 GO:0050684 regulation of mRNA processing 3.440E-6 2.568E-4 2.233E-3 1.156E-2 10 112
46 GO:0000723 telomere maintenance 3.915E-6 2.859E-4 2.486E-3 1.315E-2 11 140
47 GO:0032204 regulation of telomere maintenance 4.241E-6 2.973E-4 2.586E-3 1.424E-2 8 68
48 GO:0019058 viral life cycle 4.249E-6 2.973E-4 2.586E-3 1.427E-2 20 447
49 GO:0043488 regulation of mRNA stability 5.144E-6 3.526E-4 3.067E-3 1.728E-2 11 144
50 GO:0006913 nucleocytoplasmic transport 5.548E-6 3.727E-4 3.242E-3 1.864E-2 21 495
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 425 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016604 nuclear body 7.191E-17 3.056E-14 2.026E-13 3.056E-14 32 368
2 GO:0016607 nuclear speck 5.985E-16 1.272E-13 8.433E-13 2.544E-13 24 202
3 GO:0005681 spliceosomal complex 2.739E-14 3.881E-12 2.573E-11 1.164E-11 21 173
4 GO:0098687 chromosomal region 4.316E-10 4.586E-8 3.041E-7 1.834E-7 23 345
5 GO:0000785 chromatin 1.682E-8 1.430E-6 9.479E-6 7.148E-6 25 489
6 GO:0071013 catalytic step 2 spliceosome 4.038E-8 2.860E-6 1.896E-5 1.716E-5 11 90
7 GO:0000775 chromosome, centromeric region 1.659E-6 1.007E-4 6.678E-4 7.050E-4 13 185
8 GO:0000781 chromosome, telomeric region 2.577E-6 1.283E-4 8.509E-4 1.095E-3 12 163
9 GO:0034399 nuclear periphery 2.718E-6 1.283E-4 8.509E-4 1.155E-3 11 136
10 GO:0000776 kinetochore 7.963E-6 3.384E-4 2.244E-3 3.384E-3 10 124
11 GO:0031965 nuclear membrane 1.169E-5 4.517E-4 2.995E-3 4.969E-3 15 290
12 GO:0036464 cytoplasmic ribonucleoprotein granule 2.950E-5 1.045E-3 6.928E-3 1.254E-2 10 144
13 GO:0035770 ribonucleoprotein granule 4.685E-5 1.486E-3 9.853E-3 1.991E-2 10 152
14 GO:0070937 CRD-mediated mRNA stability complex 4.895E-5 1.486E-3 9.853E-3 2.080E-2 3 6
15 GO:0005635 nuclear envelope 5.684E-5 1.610E-3 1.068E-2 2.416E-2 18 454
16 GO:0070603 SWI/SNF superfamily-type complex 6.775E-5 1.800E-3 1.193E-2 2.879E-2 7 74
17 GO:0042382 paraspeckles 8.480E-5 2.120E-3 1.406E-2 3.604E-2 3 7
18 GO:0035371 microtubule plus-end 1.390E-4 3.282E-3 2.176E-2
5.907E-2
 4 20
19 GO:0005874 microtubule 2.776E-4 5.993E-3 3.973E-2
1.180E-1
 16 427
20 GO:0031010 ISWI-type complex 2.820E-4 5.993E-3 3.973E-2
1.199E-1
 3 10
21 GO:0005819 spindle 3.383E-4 6.847E-3 4.540E-2
1.438E-1
 13 308
22 GO:0000932 P-body 4.519E-4 8.731E-3
5.789E-2
1.921E-1
 6 72
23 GO:0071564 npBAF complex 5.066E-4 9.163E-3
6.076E-2
2.153E-1
 3 12
24 GO:0000784 nuclear chromosome, telomeric region 5.175E-4 9.163E-3
6.076E-2
2.199E-1
 8 134
25 GO:1990752 microtubule end 5.390E-4 9.163E-3
6.076E-2
2.291E-1
 4 28
26 GO:0016363 nuclear matrix 6.339E-4 1.036E-2
6.870E-2
2.694E-1
 7 106
27 GO:0017053 transcriptional repressor complex 7.938E-4 1.247E-2
8.267E-2
3.374E-1
 6 80
28 GO:0071565 nBAF complex 8.215E-4 1.247E-2
8.267E-2
3.491E-1
 3 14
29 GO:0016514 SWI/SNF complex 1.016E-3 1.490E-2
9.877E-2
4.320E-1
 3 15
30 GO:0097452 GAIT complex 1.096E-3 1.503E-2
9.965E-2
4.659E-1
 2 4
31 GO:0035061 interchromatin granule 1.096E-3 1.503E-2
9.965E-2
4.659E-1
 2 4
32 GO:0010494 cytoplasmic stress granule 1.145E-3 1.521E-2
1.008E-1
4.866E-1
 4 34
33 GO:0071004 U2-type prespliceosome 1.238E-3 1.595E-2
1.058E-1
5.264E-1
 3 16
34 GO:0000792 heterochromatin 1.308E-3 1.635E-2
1.084E-1
5.558E-1
 6 88
35 GO:0044615 nuclear pore nuclear basket 1.811E-3 2.115E-2
1.402E-1
7.695E-1
 2 5
36 GO:0098791 Golgi subcompartment 1.841E-3 2.115E-2
1.402E-1
7.826E-1
 12 326
37 GO:0000790 nuclear chromatin 1.841E-3 2.115E-2
1.402E-1
7.826E-1
 12 326
38 GO:0005868 cytoplasmic dynein complex 2.079E-3 2.325E-2
1.542E-1
8.836E-1
 3 19
39 GO:0000793 condensed chromosome 2.313E-3 2.521E-2
1.671E-1
9.830E-1
 9 208
40 GO:0031984 organelle subcompartment 2.666E-3 2.833E-2
1.878E-1
1.000E0
 12 341
41 GO:0071010 prespliceosome 2.797E-3 2.899E-2
1.922E-1
1.000E0
 3 21
42 GO:0035097 histone methyltransferase complex 3.431E-3 3.472E-2
2.302E-1
1.000E0
 5 74
43 GO:0035068 micro-ribonucleoprotein complex 3.734E-3 3.691E-2
2.447E-1
1.000E0
 2 7
44 GO:0005938 cell cortex 3.829E-3 3.699E-2
2.452E-1
1.000E0
 10 267
45 GO:0090544 BAF-type complex 4.130E-3 3.900E-2
2.586E-1
1.000E0
 3 24
46 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m 4.934E-3 4.369E-2
2.897E-1
1.000E0
 2 8
47 GO:0034992 microtubule organizing center attachment site 4.934E-3 4.369E-2
2.897E-1
1.000E0
 2 8
48 GO:0034993 LINC complex 4.934E-3 4.369E-2
2.897E-1
1.000E0
 2 8
49 GO:0099568 cytoplasmic region 5.406E-3 4.689E-2
3.109E-1
1.000E0
 11 326
50 GO:0005875 microtubule associated complex 5.706E-3 4.850E-2
3.216E-1
1.000E0
 7 156
Show 45 more annotations

4: Human Phenotype [Display Chart] 872 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000527 Long eyelashes {has synonym type="layperson"} 4.639E-6 4.045E-3 2.973E-2 4.045E-3 6 38
2 HP:0002895 Papillary thyroid carcinoma 1.703E-5 7.427E-3
5.458E-2
 1.485E-2 4 14
3 HP:0000574 Thick eyebrow {has synonym type="layperson"} 1.756E-4 2.980E-2
2.190E-1
1.531E-1
 5 45
4 HP:0000028 Cryptorchidism 1.780E-4 2.980E-2
2.190E-1
1.552E-1
 12 302
5 HP:0002884 Hepatoblastoma 2.527E-4 2.980E-2
2.190E-1
2.204E-1
 3 11
6 HP:0006744 Adrenocortical carcinoma 2.527E-4 2.980E-2
2.190E-1
2.204E-1
 3 11
7 HP:0000520 Proptosis 2.804E-4 2.980E-2
2.190E-1
2.445E-1
 7 109
8 HP:0000294 Low anterior hairline 3.076E-4 2.980E-2
2.190E-1
2.682E-1
 4 28
9 HP:0000189 Narrow palate {has synonym type="layperson"} 3.076E-4 2.980E-2
2.190E-1
2.682E-1
 4 28
10 HP:0002020 Gastroesophageal reflux 3.928E-4 3.345E-2
2.458E-1
3.425E-1
 6 82
11 HP:0006254 Elevated alpha-fetoprotein 4.219E-4 3.345E-2
2.458E-1
3.679E-1
 2 3
12 HP:0001007 Hirsutism 5.083E-4 3.694E-2
2.714E-1
4.433E-1
 6 86
13 HP:0000341 Narrow forehead {has synonym type="layperson"} 5.852E-4 3.926E-2
2.885E-1
5.103E-1
 5 58
14 HP:0001337 Tremor {has synonym type="layperson"} 6.793E-4 4.057E-2
2.981E-1
5.923E-1
 7 126
15 HP:0001539 Omphalocele 8.241E-4 4.057E-2
2.981E-1
7.186E-1
 4 36
16 HP:0001566 Widely-spaced maxillary central incisors 8.374E-4 4.057E-2
2.981E-1
7.302E-1
 2 4
17 HP:0100874 Thick hair {has synonym type="layperson"} 8.374E-4 4.057E-2
2.981E-1
7.302E-1
 2 4
18 HP:0010562 Keloids 8.374E-4 4.057E-2
2.981E-1
7.302E-1
 2 4
19 HP:0000219 Thin upper lip vermilion 1.075E-3 4.935E-2
3.626E-1
9.376E-1
 6 99
Show 14 more annotations

5: Mouse Phenotype [Display Chart] 2925 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0009850 embryonic lethality between implantation and placentation 1.578E-9 4.616E-6 3.950E-5 4.616E-6 28 439
2 MP:0011096 embryonic lethality between implantation and somite formation, complete penetrance 1.897E-7 1.967E-4 1.683E-3 5.550E-4 19 270
3 MP:0006205 embryonic lethality between implantation and somite formation 2.017E-7 1.967E-4 1.683E-3 5.901E-4 20 299
4 MP:0011094 embryonic lethality before implantation, complete penetrance 1.147E-6 7.273E-4 6.225E-3 3.355E-3 13 144
5 MP:0006204 embryonic lethality before implantation 1.243E-6 7.273E-4 6.225E-3 3.636E-3 14 169
6 MP:0002084 abnormal developmental patterning 2.208E-6 1.076E-3 9.211E-3 6.458E-3 24 478
7 MP:0003077 abnormal cell cycle 6.170E-6 2.578E-3 2.206E-2 1.805E-2 18 309
8 MP:0001730 embryonic growth arrest 1.853E-5 6.618E-3
5.664E-2
5.420E-2
 17 303
9 MP:0001695 abnormal gastrulation 2.036E-5 6.618E-3
5.664E-2
5.956E-2
 19 370
10 MP:0011097 embryonic lethality between somite formation and embryo turning, complete penetrance 2.381E-5 6.965E-3
5.961E-2
6.965E-2
 9 90
11 MP:0000238 absent pre-B cells 7.569E-5 1.954E-2
1.672E-1
2.214E-1
 4 14
12 MP:0008209 decreased pre-B cell number 8.122E-5 1.954E-2
1.672E-1
2.376E-1
 9 105
13 MP:0002403 abnormal pre-B cell morphology 9.931E-5 1.954E-2
1.672E-1
2.905E-1
 10 133
14 MP:0010288 increased gland tumor incidence 9.936E-5 1.954E-2
1.672E-1
2.906E-1
 15 280
15 MP:0004808 abnormal hematopoietic stem cell morphology 1.002E-4 1.954E-2
1.672E-1
2.931E-1
 11 160
16 MP:0011092 embryonic lethality, complete penetrance 1.367E-4 2.499E-2
2.139E-1
3.999E-1
 19 426
17 MP:0001606 impaired hematopoiesis 1.488E-4 2.561E-2
2.192E-1
4.353E-1
 7 67
18 MP:0005090 increased double-negative T cell number 1.640E-4 2.666E-2
2.281E-1
4.798E-1
 9 115
19 MP:0006206 embryonic lethality between somite formation and embryo turning 1.871E-4 2.880E-2
2.465E-1
5.472E-1
 9 117
20 MP:0002673 abnormal sperm number 2.035E-4 2.964E-2
2.537E-1
5.951E-1
 18 403
21 MP:0008932 abnormal embryonic tissue physiology 2.128E-4 2.964E-2
2.537E-1
6.225E-1
 15 300
22 MP:0010476 coronary fistula 2.676E-4 3.312E-2
2.835E-1
7.828E-1
 3 8
23 MP:0008213 absent immature B cells 2.739E-4 3.312E-2
2.835E-1
8.012E-1
 4 19
24 MP:0008071 absent B cells 2.783E-4 3.312E-2
2.835E-1
8.141E-1
 7 74
25 MP:0002407 abnormal double-negative T cell morphology 2.831E-4 3.312E-2
2.835E-1
8.281E-1
 11 180
26 MP:0008755 abnormal immunoglobulin V(D)J recombination 3.378E-4 3.800E-2
3.252E-1
9.880E-1
 4 20
27 MP:0008215 decreased immature B cell number 4.119E-4 4.463E-2
3.819E-1
1.000E0
 9 130
Show 22 more annotations

6: Domain [Display Chart] 1556 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00490 HELICc SMART 8.333E-15 3.030E-12 2.402E-11 1.297E-11 18 107
2 PF00271 Helicase C Pfam 8.333E-15 3.030E-12 2.402E-11 1.297E-11 18 107
3 IPR001650 Helicase C InterPro 9.877E-15 3.030E-12 2.402E-11 1.537E-11 18 108
4 PS51194 HELICASE CTER PROSITE 1.168E-14 3.030E-12 2.402E-11 1.818E-11 18 109
5 PS51192 HELICASE ATP BIND 1 PROSITE 1.168E-14 3.030E-12 2.402E-11 1.818E-11 18 109
6 SM00487 DEXDc SMART 1.168E-14 3.030E-12 2.402E-11 1.818E-11 18 109
7 IPR014001 Helicase ATP-bd InterPro 1.380E-14 3.067E-12 2.432E-11 2.147E-11 18 110
8 IPR012677 Nucleotide-bd a/b plait InterPro 2.226E-13 4.329E-11 3.432E-10 3.463E-10 24 258
9 3.30.70.330 - Gene3D 5.443E-13 9.410E-11 7.460E-10 8.469E-10 23 244
10 IPR000504 RRM dom InterPro 1.013E-12 1.576E-10 1.250E-9 1.576E-9 22 227
11 PS50102 RRM PROSITE 1.322E-12 1.870E-10 1.482E-9 2.056E-9 22 230
12 PS00633 BROMODOMAIN 1 PROSITE 1.929E-12 2.447E-10 1.940E-9 3.002E-9 11 37
13 IPR016024 ARM-type fold InterPro 2.045E-12 2.447E-10 1.940E-9 3.182E-9 26 340
14 PF00439 Bromodomain Pfam 2.682E-12 2.981E-10 2.363E-9 4.173E-9 11 38
15 SM00360 RRM SMART 3.482E-12 3.612E-10 2.864E-9 5.419E-9 21 217
16 PS50016 ZF PHD 2 PROSITE 3.948E-12 3.840E-10 3.044E-9 6.143E-9 15 95
17 PS01359 ZF PHD 1 PROSITE 4.622E-12 4.230E-10 3.353E-9 7.191E-9 15 96
18 PS50014 BROMODOMAIN 2 PROSITE 6.786E-12 5.866E-10 4.650E-9 1.056E-8 11 41
19 IPR001487 Bromodomain InterPro 9.082E-12 6.729E-10 5.334E-9 1.413E-8 11 42
20 SM00297 BROMO SMART 9.082E-12 6.729E-10 5.334E-9 1.413E-8 11 42
21 1.20.920.10 - Gene3D 9.082E-12 6.729E-10 5.334E-9 1.413E-8 11 42
22 PF00076 RRM 1 Pfam 1.305E-11 9.233E-10 7.319E-9 2.031E-8 20 208
23 IPR001965 Znf PHD InterPro 3.008E-11 2.035E-9 1.613E-8 4.680E-8 14 91
24 PF00628 PHD Pfam 3.244E-11 2.103E-9 1.667E-8 5.048E-8 13 75
25 IPR011989 ARM-like InterPro 3.454E-11 2.150E-9 1.704E-8 5.375E-8 22 271
26 IPR018359 Bromodomain CS InterPro 4.376E-11 2.619E-9 2.076E-8 6.808E-8 9 26
27 IPR019787 Znf PHD-finger InterPro 6.436E-11 3.709E-9 2.940E-8 1.002E-7 13 79
28 IPR019786 Zinc finger PHD-type CS InterPro 8.687E-11 4.827E-9 3.827E-8 1.352E-7 12 65
29 SM00249 PHD SMART 3.030E-10 1.626E-8 1.289E-7 4.715E-7 13 89
30 1.25.10.10 - Gene3D 2.277E-9 1.181E-7 9.364E-7 3.544E-6 18 222
31 PS50827 DDT PROSITE 2.996E-9 1.504E-7 1.192E-6 4.662E-6 5 6
32 IPR011545 DEAD/DEAH box helicase dom InterPro 5.158E-9 2.432E-7 1.928E-6 8.025E-6 11 73
33 PF00270 DEAD Pfam 5.158E-9 2.432E-7 1.928E-6 8.025E-6 11 73
34 SM00298 CHROMO SMART 1.309E-8 5.820E-7 4.614E-6 2.037E-5 8 33
35 IPR000953 Chromo/shadow dom InterPro 1.309E-8 5.820E-7 4.614E-6 2.037E-5 8 33
36 IPR011011 Znf FYVE PHD InterPro 1.876E-8 8.107E-7 6.427E-6 2.918E-5 14 147
37 PS50077 HEAT REPEAT PROSITE 4.412E-8 1.855E-6 1.471E-5 6.865E-5 10 70
38 IPR028942 WHIM1 dom InterPro 1.821E-7 6.567E-6 5.206E-5 2.833E-4 4 5
39 SM00571 DDT SMART 1.821E-7 6.567E-6 5.206E-5 2.833E-4 4 5
40 IPR028941 WHIM2 dom InterPro 1.821E-7 6.567E-6 5.206E-5 2.833E-4 4 5
41 IPR018501 DDT dom InterPro 1.821E-7 6.567E-6 5.206E-5 2.833E-4 4 5
42 PF15612 WHIM1 Pfam 1.821E-7 6.567E-6 5.206E-5 2.833E-4 4 5
43 PF15613 WSD Pfam 1.821E-7 6.567E-6 5.206E-5 2.833E-4 4 5
44 PS00039 DEAD ATP HELICASE PROSITE 1.857E-7 6.567E-6 5.206E-5 2.890E-4 7 31
45 IPR000330 SNF2 N InterPro 2.349E-7 7.776E-6 6.165E-5 3.655E-4 7 32
46 PF00176 SNF2 N Pfam 2.349E-7 7.776E-6 6.165E-5 3.655E-4 7 32
47 IPR016197 Chromodomain-like InterPro 2.349E-7 7.776E-6 6.165E-5 3.655E-4 7 32
48 IPR000629 RNA-helicase DEAD-box CS InterPro 2.946E-7 9.550E-6 7.571E-5 4.584E-4 7 33
49 IPR006576 BRK domain InterPro 5.402E-7 1.648E-5 1.307E-4 8.406E-4 4 6
50 SM00592 BRK SMART 5.402E-7 1.648E-5 1.307E-4 8.406E-4 4 6
Show 45 more annotations

7: Pathway [Display Chart] 719 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 198843 mRNA processing BioSystems: WikiPathways 3.634E-12 2.613E-9 1.870E-8 2.613E-9 17 136
2 125136 Spliceosome BioSystems: KEGG 2.623E-9 9.428E-7 6.747E-6 1.886E-6 14 131
3 160950 Processing of Capped Intron-Containing Pre-mRNA BioSystems: REACTOME 7.048E-8 1.689E-5 1.209E-4 5.067E-5 13 143
4 105951 mRNA Splicing BioSystems: REACTOME 3.409E-7 4.902E-5 3.507E-4 2.451E-4 11 112
5 105952 mRNA Splicing - Major Pathway BioSystems: REACTOME 3.409E-7 4.902E-5 3.507E-4 2.451E-4 11 112
6 177876 RNA transport BioSystems: KEGG 2.370E-6 2.840E-4 2.032E-3 1.704E-3 12 164
7 730315 Resolution of Sister Chromatid Cohesion BioSystems: REACTOME 7.945E-5 8.160E-3
5.839E-2
5.712E-2
 8 103
8 105866 Recruitment of repair and signaling proteins to double-strand breaks BioSystems: REACTOME 1.327E-4 1.145E-2
8.192E-2
9.544E-2
 3 8
9 105815 Mitotic Prometaphase BioSystems: REACTOME 1.433E-4 1.145E-2
8.192E-2
1.030E-1
 8 112
10 105765 Cell Cycle, Mitotic BioSystems: REACTOME 1.740E-4 1.251E-2
8.952E-2
1.251E-1
 16 416
11 105861 Double-Strand Break Repair BioSystems: REACTOME 2.412E-4 1.577E-2
1.128E-1
1.734E-1
 4 23
12 160994 Deadenylation of mRNA BioSystems: REACTOME 2.864E-4 1.716E-2
1.228E-1
2.059E-1
 4 24
13 105812 M Phase BioSystems: REACTOME 3.314E-4 1.833E-2
1.312E-1
2.383E-1
 11 232
14 169347 Notch-mediated HES/HEY network BioSystems: Pathway Interaction Database 4.728E-4 2.319E-2
1.659E-1
3.400E-1
 5 48
15 730318 Separation of Sister Chromatids BioSystems: REACTOME 4.838E-4 2.319E-2
1.659E-1
3.479E-1
 9 168
16 105960 Transport of Mature mRNA derived from an Intron-Containing Transcript BioSystems: REACTOME 6.870E-4 2.932E-2
2.098E-1
4.939E-1
 5 52
17 576266 Pre-NOTCH Transcription and Translation BioSystems: REACTOME 6.932E-4 2.932E-2
2.098E-1
4.984E-1
 4 30
18 105818 Mitotic Anaphase BioSystems: REACTOME 7.647E-4 3.011E-2
2.155E-1
5.498E-1
 9 179
19 730317 Mitotic Metaphase and Anaphase BioSystems: REACTOME 7.957E-4 3.011E-2
2.155E-1
5.721E-1
 9 180
20 771569 Regulation of PLK1 Activity at G2/M Transition BioSystems: REACTOME 9.302E-4 3.309E-2
2.368E-1
6.688E-1
 6 83
21 105959 Transport of Mature Transcript to Cytoplasm BioSystems: REACTOME 9.665E-4 3.309E-2
2.368E-1
6.949E-1
 5 56
22 198803 Translation Factors BioSystems: WikiPathways 1.048E-3 3.425E-2
2.451E-1
7.535E-1
 5 57
23 105801 G2/M Transition BioSystems: REACTOME 1.143E-3 3.486E-2
2.495E-1
8.217E-1
 7 118
24 105863 Homologous recombination repair of replication-independent double-strand breaks BioSystems: REACTOME 1.225E-3 3.486E-2
2.495E-1
8.808E-1
 3 16
25 105862 Homologous Recombination Repair BioSystems: REACTOME 1.225E-3 3.486E-2
2.495E-1
8.808E-1
 3 16
26 160942 Mitotic G2-G2/M phases BioSystems: REACTOME 1.261E-3 3.486E-2
2.495E-1
9.064E-1
 7 120
27 105811 Loss of Nlp from mitotic centrosomes BioSystems: REACTOME 1.768E-3 4.540E-2
3.249E-1
1.000E0
 5 64
28 105810 Loss of proteins required for interphase microtubule organization from the centrosome BioSystems: REACTOME 1.768E-3 4.540E-2
3.249E-1
1.000E0
 5 64
29 137997 Signaling events mediated by HDAC Class I BioSystems: Pathway Interaction Database 2.168E-3 4.752E-2
3.401E-1
1.000E0
 5 67
30 576255 Cytosolic sensors of pathogen-associated DNA BioSystems: REACTOME 2.314E-3 4.752E-2
3.401E-1
1.000E0
 5 68
31 137939 Direct p53 effectors BioSystems: Pathway Interaction Database 2.375E-3 4.752E-2
3.401E-1
1.000E0
 7 134
32 645264 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer BioSystems: REACTOME 2.721E-3 4.752E-2
3.401E-1
1.000E0
 4 43
33 906018 SMAD4 MH2 Domain Mutants in Cancer BioSystems: REACTOME 2.974E-3 4.752E-2
3.401E-1
1.000E0
 5 72
34 906026 TGFBR1 LBD Mutants in Cancer BioSystems: REACTOME 2.974E-3 4.752E-2
3.401E-1
1.000E0
 5 72
35 906019 Loss of Function of SMAD2/3 in Cancer BioSystems: REACTOME 2.974E-3 4.752E-2
3.401E-1
1.000E0
 5 72
36 906025 Loss of Function of TGFBR1 in Cancer BioSystems: REACTOME 2.974E-3 4.752E-2
3.401E-1
1.000E0
 5 72
37 906023 TGFBR2 MSI Frameshift Mutants in Cancer BioSystems: REACTOME 2.974E-3 4.752E-2
3.401E-1
1.000E0
 5 72
38 906016 Signaling by TGF-beta Receptor Complex in Cancer BioSystems: REACTOME 2.974E-3 4.752E-2
3.401E-1
1.000E0
 5 72
39 906024 TGFBR2 Kinase Domain Mutants in Cancer BioSystems: REACTOME 2.974E-3 4.752E-2
3.401E-1
1.000E0
 5 72
40 906017 Loss of Function of SMAD4 in Cancer BioSystems: REACTOME 2.974E-3 4.752E-2
3.401E-1
1.000E0
 5 72
41 106504 Signaling by TGF-beta Receptor Complex BioSystems: REACTOME 2.974E-3 4.752E-2
3.401E-1
1.000E0
 5 72
42 906021 SMAD2/3 MH2 Domain Mutants in Cancer BioSystems: REACTOME 2.974E-3 4.752E-2
3.401E-1
1.000E0
 5 72
43 906022 Loss of Function of TGFBR2 in Cancer BioSystems: REACTOME 2.974E-3 4.752E-2
3.401E-1
1.000E0
 5 72
44 906020 SMAD2/3 Phosphorylation Motif Mutants in Cancer BioSystems: REACTOME 2.974E-3 4.752E-2
3.401E-1
1.000E0
 5 72
45 906027 TGFBR1 KD Mutants in Cancer BioSystems: REACTOME 2.974E-3 4.752E-2
3.401E-1
1.000E0
 5 72
Show 40 more annotations

8: Pubmed [Display Chart] 22661 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19454010 In vitro nuclear interactome of the HIV-1 Tat protein. Pubmed 1.161E-41 2.631E-37 2.790E-36 2.631E-37 34 195
2 24332808 PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Pubmed 2.706E-40 3.066E-36 3.251E-35 6.131E-36 39 340
3 22751105 Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. Pubmed 1.395E-34 1.054E-30 1.118E-29 3.162E-30 28 159
4 20936779 A human MAP kinase interactome. Pubmed 3.251E-34 1.842E-30 1.953E-29 7.366E-30 39 486
5 22174317 Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production. Pubmed 8.349E-33 3.784E-29 4.013E-28 1.892E-28 29 206
6 26167880 SR protein kinases promote splicing of nonconsensus introns. Pubmed 2.964E-32 9.827E-29 1.042E-27 6.716E-28 34 361
7 23125841 Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1. Pubmed 3.036E-32 9.827E-29 1.042E-27 6.879E-28 30 241
8 20020773 Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. Pubmed 9.098E-32 2.577E-28 2.733E-27 2.062E-27 29 223
9 24639526 RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. Pubmed 1.903E-31 4.792E-28 5.082E-27 4.313E-27 28 203
10 23752268 The functional interactome landscape of the human histone deacetylase family. Pubmed 2.449E-31 5.550E-28 5.886E-27 5.550E-27 31 287
11 25693804 Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. Pubmed 1.006E-30 2.072E-27 2.197E-26 2.279E-26 32 332
12 15635413 Nucleolar proteome dynamics. Pubmed 4.568E-30 8.626E-27 9.148E-26 1.035E-25 34 419
13 26641092 The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells. Pubmed 2.126E-29 3.706E-26 3.930E-25 4.818E-25 28 239
14 21182205 Identification of proteins associated with ligand-activated estrogen receptor ¿ in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. Pubmed 4.321E-29 6.994E-26 7.418E-25 9.792E-25 28 245
15 22623428 Proteomic analysis of ¿4�1 integrin adhesion complexes reveals ¿-subunit-dependent protein recruitment. Pubmed 5.346E-29 8.077E-26 8.566E-25 1.211E-24 35 491
16 17332742 Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. Pubmed 3.016E-28 4.271E-25 4.530E-24 6.834E-24 22 115
17 22113938 A bead-based approach for large-scale identification of in vitro kinase substrates. Pubmed 8.216E-28 1.095E-24 1.162E-23 1.862E-23 24 163
18 21081666 Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Pubmed 4.878E-27 6.141E-24 6.512E-23 1.105E-22 27 258
19 22952844 Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. Pubmed 1.032E-26 1.230E-23 1.305E-22 2.338E-22 23 156
20 17643375 Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Pubmed 6.098E-26 6.909E-23 7.328E-22 1.382E-21 30 390
21 15324660 Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Pubmed 8.883E-26 9.020E-23 9.566E-22 2.013E-21 26 255
22 12168954 Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. Pubmed 9.006E-26 9.020E-23 9.566E-22 2.041E-21 25 225
23 22365833 Dynamic protein-protein interaction wiring of the human spliceosome. Pubmed 9.155E-26 9.020E-23 9.566E-22 2.075E-21 24 197
24 21319273 An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. Pubmed 1.029E-25 9.714E-23 1.030E-21 2.331E-21 30 397
25 26527279 Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. Pubmed 4.098E-25 3.715E-22 3.939E-21 9.286E-21 23 182
26 16051665 Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Pubmed 3.439E-24 2.998E-21 3.179E-20 7.794E-20 18 85
27 25515538 A systems-wide screen identifies substrates of the SCFÃ?TrCP ubiquitin ligase. Pubmed 4.970E-24 4.171E-21 4.424E-20 1.126E-19 24 232
28 16565220 Phosphoproteome analysis of the human mitotic spindle. Pubmed 1.186E-23 9.595E-21 1.018E-19 2.687E-19 23 210
29 22190034 Global landscape of HIV-human protein complexes. Pubmed 9.382E-23 7.332E-20 7.776E-19 2.126E-18 29 457
30 25756610 DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. Pubmed 2.462E-22 1.860E-19 1.973E-18 5.580E-18 21 179
31 22446626 DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. Pubmed 4.360E-22 3.187E-19 3.380E-18 9.881E-18 17 89
32 17620599 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Pubmed 4.728E-22 3.348E-19 3.551E-18 1.071E-17 25 317
33 24255178 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Pubmed 7.051E-22 4.842E-19 5.135E-18 1.598E-17 28 446
34 20811636 The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. Pubmed 1.905E-21 1.269E-18 1.346E-17 4.316E-17 21 197
35 23084401 The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. Pubmed 2.093E-21 1.355E-18 1.437E-17 4.744E-17 20 169
36 23184937 Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. Pubmed 2.999E-21 1.888E-18 2.002E-17 6.796E-17 20 172
37 16055720 WW domains provide a platform for the assembly of multiprotein networks. Pubmed 9.512E-21 5.826E-18 6.179E-17 2.156E-16 19 154
38 23667531 The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. Pubmed 1.044E-20 6.228E-18 6.605E-17 2.367E-16 23 282
39 23455922 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Pubmed 1.446E-19 8.404E-17 8.913E-16 3.277E-15 26 447
40 18457437 Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry. Pubmed 2.155E-19 1.221E-16 1.295E-15 4.884E-15 18 152
41 23825951 Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing. Pubmed 1.393E-18 7.700E-16 8.166E-15 3.157E-14 12 40
42 26687479 The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. Pubmed 1.485E-18 8.015E-16 8.500E-15 3.366E-14 24 396
43 16159877 Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin. Pubmed 1.669E-18 8.798E-16 9.330E-15 3.783E-14 18 170
44 25147182 Quantitative Lys-¿-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. Pubmed 1.980E-18 1.020E-15 1.082E-14 4.487E-14 24 401
45 23398456 The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. Pubmed 4.912E-18 2.473E-15 2.623E-14 1.113E-13 22 328
46 23383273 VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. Pubmed 5.226E-18 2.574E-15 2.730E-14 1.184E-13 21 288
47 24550385 Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. Pubmed 8.821E-18 4.253E-15 4.511E-14 1.999E-13 19 220
48 19394292 Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. Pubmed 1.441E-17 6.801E-15 7.213E-14 3.265E-13 15 106
49 21549307 Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Pubmed 6.671E-17 3.085E-14 3.272E-13 1.512E-12 15 117
50 24591637 Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer. Pubmed 8.023E-17 3.636E-14 3.857E-13 1.818E-12 12 54
Show 45 more annotations

9: Interaction [Display Chart] 6271 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:RPA2 RPA2 interactions 1.686E-25 1.058E-21 9.857E-21 1.058E-21 47 443
2 int:U2AF2 U2AF2 interactions 1.388E-24 4.353E-21 4.057E-20 8.705E-21 42 357
3 int:SCARNA22 SCARNA22 interactions 6.379E-24 1.333E-20 1.243E-19 4.000E-20 27 118
4 int:RPA1 RPA1 interactions 1.091E-21 1.710E-18 1.594E-17 6.842E-18 44 470
5 int:RPA3 RPA3 interactions 1.400E-21 1.755E-18 1.636E-17 8.777E-18 40 381
6 int:BMI1 BMI1 interactions 4.485E-21 4.688E-18 4.370E-17 2.813E-17 39 371
7 int:LUC7L LUC7L interactions 1.484E-20 1.330E-17 1.239E-16 9.308E-17 24 113
8 int:SRPK2 SRPK2 interactions 5.994E-19 4.698E-16 4.379E-15 3.759E-15 40 450
9 int:LGR4 LGR4 interactions 8.581E-19 5.979E-16 5.573E-15 5.381E-15 28 198
10 int:SRSF1 SRSF1 interactions 1.358E-18 8.519E-16 7.941E-15 8.519E-15 26 167
11 int:FBXW11 FBXW11 interactions 3.965E-18 2.261E-15 2.107E-14 2.487E-14 36 377
12 int:IFI16 IFI16 interactions 4.356E-18 2.277E-15 2.122E-14 2.732E-14 35 355
13 int:RNPS1 RNPS1 interactions 8.065E-18 3.890E-15 3.626E-14 5.057E-14 26 179
14 int:TARDBP TARDBP interactions 1.917E-17 8.586E-15 8.003E-14 1.202E-13 32 304
15 int:STAU1 STAU1 interactions 3.411E-17 1.426E-14 1.329E-13 2.139E-13 32 310
16 int:SF3A1 SF3A1 interactions 4.668E-17 1.830E-14 1.705E-13 2.927E-13 24 157
17 int:SF3A2 SF3A2 interactions 1.725E-16 6.362E-14 5.930E-13 1.081E-12 23 149
18 int:NANOG NANOG interactions 1.936E-16 6.745E-14 6.287E-13 1.214E-12 38 477
19 int:PRPF40A PRPF40A interactions 5.714E-16 1.886E-13 1.758E-12 3.583E-12 25 193
20 int:EFTUD2 EFTUD2 interactions 6.338E-16 1.987E-13 1.852E-12 3.975E-12 22 141
21 int:CSNK2A1 CSNK2A1 interactions 1.102E-15 3.292E-13 3.068E-12 6.913E-12 37 476
22 int:HDAC5 HDAC5 interactions 1.257E-15 3.582E-13 3.339E-12 7.881E-12 32 351
23 int:HIST1H3E HIST1H3E interactions 1.508E-15 4.112E-13 3.833E-12 9.457E-12 25 201
24 int:SRRM2 SRRM2 interactions 3.015E-15 7.879E-13 7.344E-12 1.891E-11 26 227
25 int:EIF4A3 EIF4A3 interactions 4.164E-15 1.045E-12 9.737E-12 2.612E-11 27 251
26 int:UNK UNK interactions 4.533E-15 1.093E-12 1.019E-11 2.842E-11 29 296
27 int:TOP1 TOP1 interactions 6.475E-15 1.504E-12 1.402E-11 4.060E-11 22 157
28 int:GRK5 GRK5 interactions 7.242E-15 1.622E-12 1.512E-11 4.541E-11 23 176
29 int:SRSF11 SRSF11 interactions 1.025E-14 2.216E-12 2.065E-11 6.425E-11 17 82
30 int:HDAC11 HDAC11 interactions 3.334E-14 6.970E-12 6.496E-11 2.091E-10 20 134
31 int:CEBPA CEBPA interactions 4.311E-14 8.722E-12 8.130E-11 2.704E-10 24 211
32 int:SON SON interactions 4.914E-14 9.630E-12 8.977E-11 3.082E-10 16 76
33 int:YWHAG YWHAG interactions 1.328E-13 2.523E-11 2.351E-10 8.325E-10 31 388
34 int:RANBP2 RANBP2 interactions 1.648E-13 3.039E-11 2.833E-10 1.033E-9 19 128
35 int:LUC7L2 LUC7L2 interactions 2.158E-13 3.866E-11 3.604E-10 1.353E-9 21 166
36 int:SUZ12 SUZ12 interactions 2.390E-13 4.124E-11 3.844E-10 1.499E-9 29 345
37 int:SRSF7 SRSF7 interactions 2.433E-13 4.124E-11 3.844E-10 1.526E-9 18 114
38 int:MAGOH MAGOH interactions 2.870E-13 4.737E-11 4.415E-10 1.800E-9 22 188
39 int:RBM39 RBM39 interactions 3.868E-13 6.064E-11 5.652E-10 2.426E-9 20 152
40 int:SRRM1 SRRM1 interactions 3.868E-13 6.064E-11 5.652E-10 2.426E-9 20 152
41 int:ARRB2 ARRB2 interactions 4.274E-13 6.537E-11 6.093E-10 2.680E-9 29 353
42 int:PRPF8 PRPF8 interactions 4.387E-13 6.550E-11 6.105E-10 2.751E-9 20 153
43 int:TERF2 TERF2 interactions 5.413E-13 7.894E-11 7.358E-10 3.394E-9 25 259
44 int:FOXP3 FOXP3 interactions 1.316E-12 1.876E-10 1.749E-9 8.254E-9 31 423
45 int:LMNA LMNA interactions 1.916E-12 2.670E-10 2.489E-9 1.201E-8 25 274
46 int:IVNS1ABP IVNS1ABP interactions 3.330E-12 4.363E-10 4.067E-9 2.088E-8 14 69
47 int:TOP2B TOP2B interactions 3.330E-12 4.363E-10 4.067E-9 2.088E-8 14 69
48 int:SUMO2 SUMO2 interactions 3.340E-12 4.363E-10 4.067E-9 2.094E-8 22 212
49 int:SRSF3 SRSF3 interactions 4.196E-12 5.371E-10 5.006E-9 2.632E-8 18 134
50 int:SNRNP200 SNRNP200 interactions 4.902E-12 6.148E-10 5.731E-9 3.074E-8 19 154
Show 45 more annotations

10: Cytoband [Display Chart] 222 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1p31 1p31 3.146E-5 6.985E-3 4.179E-2 6.985E-3 4 24
2 2q11.2 2q11.2 2.635E-4 2.925E-2
1.750E-1
5.850E-2
 5 74

11: Transcription Factor Binding Site [Display Chart] 547 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$NFMUE1 Q6 V$NFMUE1 Q6 1.810E-8 5.771E-6 3.972E-5 9.902E-6 17 194
2 KCCGNSWTTT UNKNOWN KCCGNSWTTT UNKNOWN 2.110E-8 5.771E-6 3.972E-5 1.154E-5 12 89
3 GCCATNTTG V$YY1 Q6 GCCATNTTG V$YY1 Q6 9.012E-8 1.643E-5 1.131E-4 4.930E-5 21 328
4 RRCCGTTA UNKNOWN RRCCGTTA UNKNOWN 5.161E-7 7.057E-5 4.857E-4 2.823E-4 9 60
5 GGCNKCCATNK UNKNOWN GGCNKCCATNK UNKNOWN 2.058E-6 2.251E-4 1.549E-3 1.126E-3 10 90
6 V$VDR Q6 V$VDR Q6 3.608E-5 3.289E-3 2.264E-2 1.974E-2 13 207
7 V$HP1SITEFACTOR Q6 V$HP1SITEFACTOR Q6 6.532E-5 4.488E-3 3.089E-2 3.573E-2 12 189
8 TCCATTKW UNKNOWN TCCATTKW UNKNOWN 7.232E-5 4.488E-3 3.089E-2 3.956E-2 12 191
9 TAANNYSGCG UNKNOWN TAANNYSGCG UNKNOWN 7.384E-5 4.488E-3 3.089E-2 4.039E-2 7 63
10 V$CEBP Q3 V$CEBP Q3 1.356E-4 7.419E-3
5.106E-2
7.419E-2
 12 204
11 V$E2F1 Q4 01 V$E2F1 Q4 01 1.949E-4 9.692E-3
6.670E-2
1.066E-1
 11 181
12 RGAANNTTC V$HSF1 01 RGAANNTTC V$HSF1 01 2.446E-4 1.046E-2
7.200E-2
1.338E-1
 16 355
13 V$TCF11 01 V$TCF11 01 2.712E-4 1.046E-2
7.200E-2
1.483E-1
 11 188
14 V$HNF4ALPHA Q6 V$HNF4ALPHA Q6 2.979E-4 1.046E-2
7.200E-2
1.630E-1
 12 222
15 V$MZF1 02 V$MZF1 02 3.109E-4 1.046E-2
7.200E-2
1.700E-1
 11 191
16 CRGAARNNNNCGA UNKNOWN CRGAARNNNNCGA UNKNOWN 3.250E-4 1.046E-2
7.200E-2
1.778E-1
 5 37
17 V$CHOP 01 V$CHOP 01 3.251E-4 1.046E-2
7.200E-2
1.778E-1
 11 192
18 SMTTTTGT UNKNOWN SMTTTTGT UNKNOWN 4.387E-4 1.333E-2
9.175E-2
2.400E-1
 15 337
19 TCCCRNNRTGC UNKNOWN TCCCRNNRTGC UNKNOWN 6.111E-4 1.759E-2
1.211E-1
3.343E-1
 9 144
20 V$MYCMAX 03 V$MYCMAX 03 6.663E-4 1.822E-2
1.254E-1
3.645E-1
 11 209
21 V$YY1 Q6 V$YY1 Q6 8.413E-4 2.191E-2
1.508E-1
4.602E-1
 10 182
22 V$E2F Q6 01 V$E2F Q6 01 9.150E-4 2.269E-2
1.561E-1
5.005E-1
 10 184
23 V$E2F Q4 01 V$E2F Q4 01 9.539E-4 2.269E-2
1.561E-1
5.218E-1
 10 185
24 V$YY1 02 V$YY1 02 1.036E-3 2.360E-2
1.624E-1
5.664E-1
 10 187
25 V$E2F1 Q6 01 V$E2F1 Q6 01 1.123E-3 2.390E-2
1.645E-1
6.142E-1
 10 189
26 TGCGCANK UNKNOWN TGCGCANK UNKNOWN 1.174E-3 2.390E-2
1.645E-1
6.421E-1
 16 410
27 V$E2F 03 V$E2F 03 1.216E-3 2.390E-2
1.645E-1
6.652E-1
 10 191
28 V$PAX8 01 V$PAX8 01 1.224E-3 2.390E-2
1.645E-1
6.693E-1
 4 29
29 V$PTF1BETA Q6 V$PTF1BETA Q6 1.368E-3 2.494E-2
1.717E-1
7.482E-1
 10 194
30 V$COUP DR1 Q6 V$COUP DR1 Q6 1.368E-3 2.494E-2
1.717E-1
7.482E-1
 10 194
31 GCGSCMNTTT UNKNOWN GCGSCMNTTT UNKNOWN 1.883E-3 3.323E-2
2.287E-1
1.000E0
 5 54
32 V$USF 01 V$USF 01 2.214E-3 3.503E-2
2.411E-1
1.000E0
 10 207
33 V$PPAR DR1 Q2 V$PPAR DR1 Q2 2.214E-3 3.503E-2
2.411E-1
1.000E0
 10 207
34 V$SMAD Q6 V$SMAD Q6 2.214E-3 3.503E-2
2.411E-1
1.000E0
 10 207
35 V$PPARG 01 V$PPARG 01 2.241E-3 3.503E-2
2.411E-1
1.000E0
 4 34
36 V$E2F Q3 V$E2F Q3 2.593E-3 3.724E-2
2.563E-1
1.000E0
 9 177
37 V$SOX5 01 V$SOX5 01 2.635E-3 3.724E-2
2.563E-1
1.000E0
 10 212
38 GCTNWTTGK UNKNOWN GCTNWTTGK UNKNOWN 2.637E-3 3.724E-2
2.563E-1
1.000E0
 11 248
39 V$MAX 01 V$MAX 01 2.726E-3 3.724E-2
2.563E-1
1.000E0
 10 213
40 V$PAX8 B V$PAX8 B 2.730E-3 3.724E-2
2.563E-1
1.000E0
 6 85
41 GGCNNMSMYNTTG UNKNOWN GGCNNMSMYNTTG UNKNOWN 2.791E-3 3.724E-2
2.563E-1
1.000E0
 5 59
42 V$PAX4 01 V$PAX4 01 3.117E-3 4.060E-2
2.794E-1
1.000E0
 10 217
43 V$LEF1 Q6 V$LEF1 Q6 3.552E-3 4.518E-2
3.110E-1
1.000E0
 10 221
44 AAGWWRNYGGC UNKNOWN AAGWWRNYGGC UNKNOWN 3.839E-3 4.772E-2
3.285E-1
1.000E0
 6 91
45 V$E2F4DP1 01 V$E2F4DP1 01 4.014E-3 4.880E-2
3.359E-1
1.000E0
 9 189
Show 40 more annotations

12: Gene Family [Display Chart] 124 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 725 RNA binding motif containing genenames.org 8.253E-14 1.023E-11 5.528E-11 1.023E-11 20 213
2 88 PHD finger proteins genenames.org 8.856E-12 5.491E-10 2.966E-9 1.098E-9 13 90
3 499 DEAD-box helicases genenames.org 2.317E-7 9.578E-6 5.173E-5 2.873E-5 7 42
4 694 Protein phosphatase 1 regulatory subunits|BCL2 family genenames.org 4.295E-7 1.332E-5 7.193E-5 5.326E-5 12 181
5 532 GATA zinc finger domain containing|Myb/SANT domain containing genenames.org 1.202E-6 2.982E-5 1.611E-4 1.491E-4 7 53
6 418 AT-rich interaction domain containing genenames.org 1.408E-5 2.910E-4 1.572E-3 1.746E-3 4 15
7 785 Ubiquitin protein ligase E3 component n-recognins genenames.org 3.745E-5 6.634E-4 3.583E-3 4.644E-3 3 7
8 579 G-patch domain containing|Minor histocompatibility antigens genenames.org 7.127E-5 1.105E-3 5.967E-3 8.838E-3 4 22
9 1168 RNA helicases genenames.org 1.712E-4 2.359E-3 1.274E-2 2.123E-2 3 11
10 403 Ankyrin repeat domain containing genenames.org 2.268E-4 2.812E-3 1.519E-2 2.812E-2 10 242
11 89 Zinc fingers RANBP2-type genenames.org 1.278E-3 1.441E-2
7.784E-2
1.585E-1
 3 21
12 1050 Topoisomerases genenames.org 1.567E-3 1.494E-2
8.071E-2
1.943E-1
 2 6
13 699 Protein phosphatase 6 regulatory subunits genenames.org 1.567E-3 1.494E-2
8.071E-2
1.943E-1
 2 6
14 485 PHD finger proteins|AT-rich interaction domain containing|Lysine demethylases|EMSY complex genenames.org 1.901E-3 1.589E-2
8.582E-2
2.358E-1
 3 24
15 775 Basic helix-loop-helix proteins|Lysine acetyltransferases|Trinucleotide repeat containing genenames.org 2.144E-3 1.589E-2
8.582E-2
2.659E-1
 3 25
16 761 Structural maintenance of chromosomes proteins|Cohesin complex genenames.org 2.178E-3 1.589E-2
8.582E-2
2.701E-1
 2 7
17 547 Exportins genenames.org 2.178E-3 1.589E-2
8.582E-2
2.701E-1
 2 7
18 939 EF-hand domain containing|Plakins genenames.org 2.884E-3 1.987E-2
1.073E-1
3.577E-1
 2 8
19 396 Zinc fingers MYND-type|A-kinase anchoring proteins genenames.org 3.644E-3 2.378E-2
1.285E-1
4.518E-1
 3 30
20 1051 Nucleoporins genenames.org 4.385E-3 2.718E-2
1.468E-1
5.437E-1
 3 32
21 1023 CCR4-NOT transcription complex genenames.org 5.551E-3 3.188E-2
1.722E-1
6.883E-1
 2 11
22 73 Zinc fingers CCCH-type|RNA binding motif containing genenames.org 5.656E-3 3.188E-2
1.722E-1
7.013E-1
 3 35
23 362 WD repeat domain containing genenames.org 6.186E-3 3.335E-2
1.801E-1
7.671E-1
 8 262
24 737 RNA binding motif containing|Serine and arginine rich splicing factors genenames.org 6.616E-3 3.418E-2
1.846E-1
8.204E-1
 2 12
25 769 Tetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome genenames.org 7.016E-3 3.480E-2
1.880E-1
8.700E-1
 5 115
26 1121 Eukaryotic translation initiation factor 3 genenames.org 7.765E-3 3.566E-2
1.926E-1
9.629E-1
 2 13
27 538 WD repeat domain containing|Dyneins, cytoplasmic genenames.org 7.765E-3 3.566E-2
1.926E-1
9.629E-1
 2 13
28 1104 Pleckstrin homology domain containing|Myosins, class X|FERM domain containing genenames.org 1.039E-2 4.600E-2
2.485E-1
1.000E0
 1 1
Show 23 more annotations

13: Coexpression [Display Chart] 6077 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13522 Common down-regulated transcripts in fibroblasts expressing either XP/CS or TDD mutant forms of ERCC3 [GeneID=2071], after UVC irradiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.289E-36 2.606E-32 2.421E-31 2.606E-32 54 483
2 M8702 Genes down-regulated in NHEK cells (normal keratinocytes) by UV-B irradiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.098E-30 1.853E-26 1.721E-25 3.705E-26 41 317
3 M3898 Genes down-regulated in NHEK cells (normal epidermal keratinocytes) after UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.418E-27 2.873E-24 2.669E-23 8.618E-24 46 485
4 M1913 Genes down-regulated in neural stem cells (NSC) at 36 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.719E-25 7.169E-22 6.660E-21 2.868E-21 30 185
5 GSE25146 UNSTIM VS HELIOBACTER PYLORI LPS STIM AGS CELL DN Genes down-regulated in AGS cells (gastric adenocarcinoma): control versus H. pylori LPS. MSigDB C7: Immunologic Signatures (v5.1) 5.686E-23 6.910E-20 6.420E-19 3.455E-19 27 162
6 M2196 Genes significantly de-regulated (p < 0.05) by MIR21 [GeneID=406991] in A172 cells (glioma). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.103E-21 2.130E-18 1.979E-17 1.278E-17 32 289
7 M19488 Genes up-regulated in nasopharyngeal carcinoma (NPC) positive for LMP1 [GeneID=9260], a latent gene of Epstein-Barr virus (EBV). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.259E-20 1.093E-17 1.015E-16 7.651E-17 36 408
8 M29 Genes whose expression positively correlated with that of SMARCA2 [GeneID=6595] in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.522E-20 3.435E-17 3.191E-16 2.748E-16 36 424
9 GSE27241 WT VS RORGT KO TH17 POLARIZED CD4 TCELL TREATED WITH DIGOXIN UP Genes up-regulated in polarizing CD4 [GeneID=920] Th17 cells treated by digoxin [PubChem=2724385]: wildtype versus RORC [GeneID=6097] knockout. MSigDB C7: Immunologic Signatures (v5.1) 5.741E-20 3.877E-17 3.601E-16 3.489E-16 25 170
10 M16036 Genes up-regulated in metastatic tumors from the whole panel of patients with prostate cancer. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.997E-16 1.821E-13 1.692E-12 1.821E-12 24 218
11 M2334 Genes translationally up-regulated by serum in MEF cells (embryonic fibroblast) lacking TSC2 [GeneID=7249]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.502E-14 1.383E-11 1.284E-10 1.521E-10 12 39
12 GSE14415 FOXP3 KO NATURAL TREG VS TCONV UP Genes up-regulated in natural T reg with non-functional FOXP3 [GeneID=50943] versus T conv. MSigDB C7: Immunologic Signatures (v5.1) 3.036E-14 1.537E-11 1.428E-10 1.845E-10 20 171
13 M7102 Genes selected in supervised analyses to discriminate cells expressing activated beta-catenin (CTNNB1) [GeneID=1499] oncogene from control cells expressing GFP. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.475E-14 3.027E-11 2.812E-10 3.935E-10 15 82
14 M5275 Genes up-regulated in blood samples from bladder cancer patients. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.357E-13 5.892E-11 5.474E-10 8.249E-10 28 404
15 M5657 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with acute influenza infection versus PBMC from patients with acute S. pneumoniae infection. MSigDB C7: Immunologic Signatures (v5.1) 2.803E-13 1.135E-10 1.055E-9 1.703E-9 19 169
16 M1810 Cluster G6: genes increasingly down-regulated in NHEK cells (normal keratinocyte) after UV-B irradiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.889E-13 1.857E-10 1.725E-9 2.971E-9 18 152
17 M7995 Genes from 'subtype S2' signature of hepatocellular carcinoma (HCC): proliferation, MYC and AKT1 [GeneID=4609;207] activation. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.924E-13 2.833E-10 2.631E-9 4.815E-9 16 115
18 M6826 Genes down-regulated in monocytes: untreated versus anti- FcgRIIB. MSigDB C7: Immunologic Signatures (v5.1) 1.327E-12 4.480E-10 4.161E-9 8.063E-9 18 161
19 M14877 Genes down-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [GeneID=4904] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.702E-12 5.443E-10 5.057E-9 1.034E-8 26 383
20 M17621 Genes up-regulated 9 h after induction of HoxA5 [GeneID=3205] expression in a breast cancer cell line. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.612E-12 1.401E-9 1.302E-8 2.803E-8 20 223
21 GSE21927 SPLENIC VS TUMOR MONOCYTES FROM C26GM TUMOROUS MICE BALBC DN Genes down-regulated in CD11b+ cells from BALB/c mice bearing C26GM colon carcinoma: spleen versus tumor. MSigDB C7: Immunologic Signatures (v5.1) 5.314E-12 1.468E-9 1.364E-8 3.229E-8 19 199
22 M4928 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those at day 3 post-vaccination. MSigDB C7: Immunologic Signatures (v5.1) 5.314E-12 1.468E-9 1.364E-8 3.229E-8 19 199
23 M3197 Genes down-regulated in comparison of IgD- peripheral blood B cells versus dark zone germinal center B cells. MSigDB C7: Immunologic Signatures (v5.1) 5.809E-12 1.471E-9 1.366E-8 3.530E-8 19 200
24 GSE21380 NON TFH VS GERMINAL CENTER TFH CD4 TCELL DN Genes down-regulated in CD4 [GeneID=920] T cells: non-Tfh versus Tfh (T follicular helper) from germinal center. MSigDB C7: Immunologic Signatures (v5.1) 5.809E-12 1.471E-9 1.366E-8 3.530E-8 19 200
25 M6697 Genes up-regulated in endothelial cells: interferon alpha versus IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v5.1) 2.345E-11 5.700E-9 5.295E-8 1.425E-7 17 166
26 M2535 The '3/3 signature': genes consistently down-regulated in all three pools of normal mammary stem cells (defined by their ability to retain the dye PKH26). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.952E-11 6.899E-9 6.409E-8 1.794E-7 16 145
27 M11318 Genes down-regulated in the MM1S cells (multiple myeloma) after treatment with aplidin [PubChem=44152164], a marine-derived compound with potential anti-cancer properties. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.468E-11 7.805E-9 7.251E-8 2.107E-7 20 249
28 GSE12003 MIR223 KO VS WT BM PROGENITOR 4D CULTURE UP Genes up-regulated in 4 day cultures of bone marrow progenitors: wildtype versus MIR223 [GeneID=407008] knockout. MSigDB C7: Immunologic Signatures (v5.1) 5.254E-11 1.030E-8 9.568E-8 3.193E-7 18 200
29 M6938 Genes down-regulated in B lymphocytes: CpG oligodeoxynucleotide 1826 versus PL2-3 (Chromatin IC). MSigDB C7: Immunologic Signatures (v5.1) 5.254E-11 1.030E-8 9.568E-8 3.193E-7 18 200
30 GSE21927 SPLEEN C57BL6 VS EL4 TUMOR BALBC MONOCYTES UP Genes up-regulated in CD11b+ from spleen of healthy C57BL6 versus CD11b+ cells from tumors of C57BL6 mice bearing EL4 lymphoma. MSigDB C7: Immunologic Signatures (v5.1) 5.254E-11 1.030E-8 9.568E-8 3.193E-7 18 200
31 GSE21927 C26GM VS 4T1 TUMOR MONOCYTE BALBC DN Genes down-regulated in CD11b+ cells from BALB/c mice bearing: C26GM colon carcinoma versus 4T1 mammary carcinoma. MSigDB C7: Immunologic Signatures (v5.1) 5.254E-11 1.030E-8 9.568E-8 3.193E-7 18 200
32 M14973 Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC1 [GeneID=3065] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.727E-11 1.642E-8 1.525E-7 5.303E-7 26 457
33 GSE7596 AKT TRANSD VS CTRL CD4 TCONV WITH TGFB UP Genes up-regulated in T conv in response to TGF-beta: expressing constantly active form of AKT1 [GeneID=207] versus control. MSigDB C7: Immunologic Signatures (v5.1) 8.984E-11 1.642E-8 1.525E-7 5.459E-7 16 156
34 M9516 Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA2 [GeneID=675] across a compendium of normal tissues. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.185E-11 1.642E-8 1.525E-7 5.582E-7 25 423
35 M15150 Genes up-regulated in cancer stem cells isolated from mammary tumors compared to the non-tumorigenic cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.015E-10 1.762E-8 1.637E-7 6.168E-7 25 425
36 M11891 The postradiation tumor escape signature: genes up-regulated in tumors from irradiated stroma vs those from non-irradiated stroma. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.140E-10 1.925E-8 1.788E-7 6.929E-7 24 393
37 M2536 Proteins interacting with AIRE [GeneID=326], based on massspectroscopy analysis of co-immunoprecipitates in 293T cells (embryonic kidney). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.363E-10 2.218E-8 2.061E-7 8.286E-7 10 45
38 M8880 Genes down-regulated during pubertal mammary gland development between week 5 and 6. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.387E-10 2.218E-8 2.061E-7 8.430E-7 15 137
39 M18441 Genes down-regulated in samples with systolic heart failure compared to normal hearts. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.501E-10 2.338E-8 2.172E-7 9.119E-7 19 241
40 M7484 Genes down-regulated in SCC12B2 cells (squamous cell carcinoma) by UV-B irradiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.434E-10 5.217E-8 4.846E-7 2.087E-6 14 123
41 M5655 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with acute influenza infection versus PBMC from patients with acute S. aureus infection. MSigDB C7: Immunologic Signatures (v5.1) 3.564E-10 5.282E-8 4.907E-7 2.166E-6 16 171
42 M1558 Strongly down-regulated at 2 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.721E-10 5.384E-8 5.002E-7 2.261E-6 9 36
43 M2864 Genes down-regulated in epithelial lung cancer cell lines upon over-expression of an oncogenic form of KRAS [Gene ID=3845] gene and knockdown of TBK1 [Gene ID=29110] gene by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 4.370E-10 6.176E-8 5.738E-7 2.656E-6 20 287
44 M2451 Genes down-regulated after 1 h of TGFB1 [GeneID=7040] stimulation in MEF cells (embryonic fibroblast) with NFIC [GeneID=4782] knockout vs wild type MEFs. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.806E-10 8.018E-8 7.449E-7 3.528E-6 13 106
45 M13893 Genes down-regulated in Daudi cells (B lymphocytes) stably expressing CD5 [GeneID=921] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.381E-10 9.968E-8 9.260E-7 4.486E-6 24 431
46 GSE21033 1H VS 12H POLYIC STIM DC DN Genes down-regulated in bone marrow-derived dendritic cellstreated by poly(IC): 1h versus 12h. MSigDB C7: Immunologic Signatures (v5.1) 1.079E-9 1.426E-7 1.325E-6 6.559E-6 14 134
47 M2379 Genes up-regulated in hypertrophic hearts (due to expression of constitutively active form of PPP3CA [GeneID=5530]) and predicted to be targets of miR-30 microRNA. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.801E-9 2.281E-7 2.119E-6 1.095E-5 13 116
48 M19849 Genes down-regulated in T helper cells (defines as CD4+) isolated from patients with mucosis fungoides compared to those from normal control donors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.801E-9 2.281E-7 2.119E-6 1.095E-5 13 116
49 GSE16385 IL4 VS ROSIGLITAZONE STIM MACROPHAGE UP Genes up-regulated in macrophages (12h): IL4 [GeneID=3565] versus rosiglitazone [PubChem=77999]. MSigDB C7: Immunologic Signatures (v5.1) 3.070E-9 3.731E-7 3.466E-6 1.866E-5 16 198
50 GSE21360 PRIMARY VS QUATERNARY MEMORY CD8 TCELL DN Genes down-regulated in memory CD8 T cells: 1' versus 4'. MSigDB C7: Immunologic Signatures (v5.1) 3.070E-9 3.731E-7 3.466E-6 1.866E-5 16 198
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2148 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Facebase RNAseq e10.5 Neural Epithelium Flanking Eminence 1000 K2 FacebaseRNAseq e10.5 Neural Epithelium Flanking Eminence top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 1.379E-41 2.962E-38 2.443E-37 2.962E-38 51 311
2 gudmap developingKidney e15.5 cortic collect duct 1000 k4 DevelopingKidney e15.5 cortic collect duct emap-28132 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.430E-38 1.535E-35 1.267E-34 3.071E-35 52 375
3 Facebase RNAseq e8.5 Floor Plate 2500 K1 FacebaseRNAseq e8.5 Floor Plate top-relative-expression-ranked 2500 k-means-cluster#1 FaceBase_RNAseq 1.318E-33 9.438E-31 7.786E-30 2.832E-30 52 469
4 gudmap developingKidney e15.5 ureter tip flank cortic collct 1000 k5 DevelopingKidney e15.5 ureter tip flank cortic collct emap-27752 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.296E-31 1.233E-28 1.017E-27 4.932E-28 44 339
5 gudmap developingKidney e15.5 1000 k3 DevelopingKidney e15.5 anlage of loop of Henle emap-31283 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.282E-30 9.805E-28 8.089E-27 4.903E-27 45 379
6 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k2 1000 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.342E-29 4.803E-27 3.963E-26 2.882E-26 42 330
7 Facebase RNAseq e10.5 Mandibular Arch 500 K5 FacebaseRNAseq e10.5 Mandibular Arch top-relative-expression-ranked 500 k-means-cluster#5 FaceBase_RNAseq 3.510E-28 1.077E-25 8.885E-25 7.539E-25 33 186
8 Facebase RNAseq e10.5 Maxillary Arch 1000 K3 FacebaseRNAseq e10.5 Maxillary Arch top-relative-expression-ranked 1000 k-means-cluster#3 FaceBase_RNAseq 6.636E-28 1.782E-25 1.470E-24 1.425E-24 45 432
9 gudmap developingKidney e15.5 Medullary collecting duct 1000 k4 DevelopingKidney e15.5 Medullary collecting duct emap-28063 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 7.560E-28 1.804E-25 1.489E-24 1.624E-24 37 261
10 Facebase RNAseq e10.5 Neural Epithelium Flanking Eminence 500 K3 FacebaseRNAseq e10.5 Neural Epithelium Flanking Eminence top-relative-expression-ranked 500 k-means-cluster#3 FaceBase_RNAseq 1.036E-27 2.224E-25 1.835E-24 2.224E-24 33 192
11 gudmap developingLowerUrinaryTract e14.5 urogenital sinus 1000 k4 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-5517 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 7.933E-26 1.549E-23 1.278E-22 1.704E-22 41 385
12 gudmap developingGonad e12.5 epididymis 500 DevelopingGonad e12.5 epididymis emap-29139 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.710E-25 8.431E-23 6.956E-22 1.012E-21 41 403
13 54Dp SubClass 54Dp 5 Top 500 Cluster 2 54Dp SubClass 54Dp 5 Top 500 Cluster 2 Brain Map - Allen iN 1.857E-24 3.069E-22 2.532E-21 3.990E-21 22 74
14 gudmap developingGonad e14.5 epididymis 500 DevelopingGonad e14.5 epididymis emap-29141 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.142E-22 1.736E-20 1.432E-19 2.452E-19 39 413
15 26Dn SubClass 26Dn 3 Top 500 Cluster 0 26Dn SubClass 26Dn 3 Top 500 Cluster 0 Brain Map - Allen iN 1.212E-22 1.736E-20 1.432E-19 2.603E-19 21 76
16 gudmap developingKidney e15.5 500 k3 DevelopingKidney e15.5 anlage of loop of Henle emap-31283 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.209E-22 4.308E-20 3.554E-19 6.892E-19 29 201
17 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k3 1000 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.881E-21 2.377E-19 1.961E-18 4.041E-18 36 369
18 gudmap developingLowerUrinaryTract e14.5 bladder 1000 k5 DevelopingLowerUrinaryTract e14.5 bladder emap-30872 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.425E-21 2.894E-19 2.388E-18 5.209E-18 37 397
19 gudmap developingKidney e15.5 Cap mesenchyme 1000 k5 DevelopingKidney e15.5 Cap mesenchyme emap-27738 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.521E-21 3.981E-19 3.284E-18 7.563E-18 25 146
20 26Dn SubClass 26Dn 3 Top 500 All 26Dn SubClass 26Dn 3 Top 500 All Brain Map - Allen iN 7.672E-20 8.240E-18 6.798E-17 1.648E-16 38 467
21 gudmap developingGonad e11.5 ovary + mesonephros 500 DevelopingGonad e11.5 ovary + mesonephros emap-3226 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.118E-19 1.143E-17 9.431E-17 2.401E-16 36 417
22 gudmap developingGonad e16.5 testes 1000 k3 DevelopingGonad e16.5 testes emap-8444 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.472E-19 3.389E-17 2.796E-16 7.457E-16 34 378
23 gudmap developingGonad e16.5 epididymis 500 DevelopingGonad e16.5 epididymis emap-29702 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.246E-19 3.966E-17 3.272E-16 9.121E-16 35 407
24 gudmap developingGonad e12.5 ovary 500 DevelopingGonad e12.5 ovary emap-28876 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.969E-19 4.447E-17 3.669E-16 1.067E-15 35 409
25 gudmap developingKidney e15.5 cortic collect duct 500 k4 DevelopingKidney e15.5 cortic collect duct emap-28132 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 8.829E-19 7.586E-17 6.258E-16 1.897E-15 24 163
26 gudmap developingGonad e16.5 ovary 1000 k2 DevelopingGonad e16.5 ovary emap-9563 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.219E-18 1.833E-16 1.512E-15 4.767E-15 27 230
27 gudmap developingGonad e18.5 ovary 1000 k2 DevelopingGonad e18.5 ovary emap-12283 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.540E-18 2.021E-16 1.667E-15 5.457E-15 26 210
28 54Dp SubClass 54Dp 5 Top 500 All 54Dp SubClass 54Dp 5 Top 500 All Brain Map - Allen iN 2.767E-18 2.123E-16 1.751E-15 5.944E-15 36 460
29 gudmap developingLowerUrinaryTract e14.5 urethra 1000 k2 DevelopingLowerUrinaryTract e14.5 urethra emap-30892 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 7.673E-18 5.683E-16 4.688E-15 1.648E-14 30 312
30 Facebase RNAseq e8.5 Hind Brain Neural Epithelium 1000 K5 FacebaseRNAseq e8.5 Hind Brain Neural Epithelium top-relative-expression-ranked 1000 k-means-cluster#5 FaceBase_RNAseq 1.499E-17 1.074E-15 8.857E-15 3.221E-14 25 204
31 gudmap developingGonad e11.5 ovary + mesonephros k2 1000 DevelopingGonad e11.5 ovary + mesonephros emap-3226 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.019E-17 1.399E-15 1.154E-14 4.336E-14 30 323
32 gudmap developingGonad e14.5 epididymis 1000 k3 DevelopingGonad e14.5 epididymis emap-29141 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.493E-17 1.673E-15 1.380E-14 5.354E-14 28 276
33 Facebase RNAseq e10.5 Neural Epithelium Overlying Lateral Eminence 500 K5 FacebaseRNAseq e10.5 Neural Epithelium Overlying Lateral Eminence top-relative-expression-ranked 500 k-means-cluster#5 FaceBase_RNAseq 3.451E-17 2.247E-15 1.853E-14 7.414E-14 26 233
34 gudmap developingGonad e11.5 ovary + mesonephros k4 1000 DevelopingGonad e11.5 ovary + mesonephros emap-3226 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.712E-17 4.240E-15 3.498E-14 1.442E-13 22 156
35 gudmap developingGonad e16.5 ovary 1000 k1 DevelopingGonad e16.5 ovary emap-9563 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.552E-16 9.523E-15 7.856E-14 3.333E-13 23 182
36 Facebase RNAseq e10.5 Neural Epithelium Flanking Eminence 500 FacebaseRNAseq e10.5 Neural Epithelium Flanking Eminence top-relative-expression-ranked 500 FaceBase_RNAseq 2.404E-16 1.435E-14 1.183E-13 5.164E-13 35 498
37 Facebase RNAseq e10.5 Lateral Nasal Eminence 1000 K3 FacebaseRNAseq e10.5 Lateral Nasal Eminence top-relative-expression-ranked 1000 k-means-cluster#3 FaceBase_RNAseq 9.042E-16 5.250E-14 4.331E-13 1.942E-12 27 291
38 Facebase RNAseq e10.5 Mandibular Arch 500 FacebaseRNAseq e10.5 Mandibular Arch top-relative-expression-ranked 500 FaceBase_RNAseq 1.170E-15 6.613E-14 5.455E-13 2.513E-12 34 493
39 Facebase RNAseq e10.5 Medial Nasal Eminence 1000 K4 FacebaseRNAseq e10.5 Medial Nasal Eminence top-relative-expression-ranked 1000 k-means-cluster#4 FaceBase_RNAseq 1.637E-15 9.013E-14 7.436E-13 3.515E-12 27 298
40 gudmap developingGonad e16.5 epididymis 1000 k1 DevelopingGonad e16.5 epididymis emap-29702 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.919E-15 1.031E-13 8.502E-13 4.122E-12 19 124
41 gudmap developingGonad e18.5 epididymis 1000 k3 DevelopingGonad e18.5 epididymis emap-13166 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.383E-15 1.772E-13 1.462E-12 7.266E-12 26 281
42 gudmap developingGonad e12.5 epididymis k3 1000 DevelopingGonad e12.5 epididymis emap-29139 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.410E-15 2.255E-13 1.861E-12 9.472E-12 25 259
43 gudmap developingGonad e12.5 epididymis k1 1000 DevelopingGonad e12.5 epididymis emap-29139 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.275E-15 2.635E-13 2.174E-12 1.133E-11 25 261
44 gudmap developingGonad P2 ovary 1000 k5 DevelopingGonad P2 ovary emap-30224 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.215E-15 3.034E-13 2.503E-12 1.335E-11 20 151
45 gudmap developingGonad e14.5 testes 1000 k5 DevelopingGonad e14.5 testes emap-6710 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.549E-15 3.126E-13 2.579E-12 1.407E-11 31 429
46 gudmap developingKidney e15.5 anlage of loop of Henle 500 DevelopingKidney e15.5 anlage of loop of Henle emap-31283 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.831E-15 3.616E-13 2.983E-12 1.682E-11 30 402
47 gudmap developingGonad e12.5 testes k4 500 DevelopingGonad e12.5 testes emap-29069 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.912E-15 3.616E-13 2.983E-12 1.700E-11 24 241
48 26Dp SubClass 26Dp 3 Top 500 All 26Dp SubClass 26Dp 3 Top 500 All Brain Map - Allen iN 8.620E-15 3.858E-13 3.182E-12 1.852E-11 32 464
49 gudmap developingGonad P2 testes 1000 k2 DevelopingGonad P2 testes emap-30171 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.064E-14 4.663E-13 3.847E-12 2.285E-11 28 349
50 26Dp SubClass 26Dp 3 Top 500 Cluster 2 26Dp SubClass 26Dp 3 Top 500 Cluster 2 Brain Map - Allen iN 3.154E-14 1.355E-12 1.118E-11 6.774E-11 13 49
Show 45 more annotations

15: Computational [Display Chart] 475 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GCM RAB10 Neighborhood of RAB10 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.939E-10 9.210E-8 6.209E-7 9.210E-8 19 151
2 GCM MAP4K4 Neighborhood of MAP4K4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 9.375E-10 2.226E-7 1.501E-6 4.453E-7 18 147
3 GCM MYST2 Neighborhood of MYST2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.199E-9 5.065E-7 3.414E-6 1.519E-6 17 140
4 module 183 Genes in module 183 MSigDb: C4 - CM: Cancer Modules 2.311E-8 2.744E-6 1.850E-5 1.098E-5 11 59
5 MORF CDC10 Neighborhood of CDC10 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.955E-8 2.808E-6 1.893E-5 1.404E-5 15 124
6 GCM BMPR2 Neighborhood of BMPR2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.469E-7 1.163E-5 7.840E-5 6.978E-5 11 70
7 GNF2 RBBP6 Neighborhood of RBBP6 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.878E-7 1.273E-5 8.580E-5 8.920E-5 10 57
8 GCM RAN Neighborhood of RAN MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.143E-7 1.273E-5 8.580E-5 1.018E-4 16 164
9 GNF2 HDAC1 Neighborhood of HDAC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.884E-7 1.522E-5 1.026E-4 1.370E-4 12 91
10 GCM CALM1 Neighborhood of CALM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.674E-7 1.745E-5 1.177E-4 1.745E-4 12 93
11 MORF ACP1 Neighborhood of ACP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 9.557E-7 4.127E-5 2.782E-4 4.540E-4 16 183
12 GCM DFFA Neighborhood of DFFA MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.129E-6 4.467E-5 3.012E-4 5.361E-4 12 103
13 MORF HDAC2 Neighborhood of HDAC2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.405E-6 5.134E-5 3.461E-4 6.675E-4 19 260
14 GCM CSNK1A1 Neighborhood of CSNK1A1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.819E-6 6.173E-5 4.161E-4 8.642E-4 7 30
15 MORF TERF1 Neighborhood of TERF1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.304E-6 6.895E-5 4.648E-4 1.095E-3 9 58
16 GCM PTK2 Neighborhood of PTK2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.322E-6 6.895E-5 4.648E-4 1.103E-3 13 130
17 MORF AATF Neighborhood of AATF MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.419E-6 1.235E-4 8.325E-4 2.099E-3 15 182
18 MORF SMC1L1 Neighborhood of SMC1L1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.912E-6 1.278E-4 8.613E-4 2.333E-3 8 48
19 GCM ZNF198 Neighborhood of ZNF198 MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.110E-6 1.278E-4 8.613E-4 2.427E-3 11 99
20 MORF EIF4A2 Neighborhood of EIF4A2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.829E-6 1.622E-4 1.093E-3 3.244E-3 12 122
21 GCM CRKL Neighborhood of CRKL MSigDb: C4 - CGN: Cancer Gene Neighborhood 7.865E-6 1.779E-4 1.199E-3 3.736E-3 8 51
22 GCM UBE2N Neighborhood of UBE2N MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.035E-5 2.234E-4 1.506E-3 4.916E-3 12 127
23 GNF2 MSH2 Neighborhood of MSH2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.101E-5 2.273E-4 1.532E-3 5.228E-3 6 26
24 GCM DDX5 Neighborhood of DDX5 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.402E-5 2.776E-4 1.871E-3 6.662E-3 8 55
25 GCM HBP1 Neighborhood of HBP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.838E-5 3.492E-4 2.354E-3 8.731E-3 8 57
26 MORF RAD54L Neighborhood of RAD54L MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.042E-5 3.731E-4 2.516E-3 9.702E-3 10 94
27 MORF DEK Neighborhood of DEK MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.402E-5 4.225E-4 2.848E-3 1.141E-2 16 235
28 GNF2 APEX1 Neighborhood of APEX1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.499E-5 4.240E-4 2.858E-3 1.187E-2 9 77
29 MORF PRKDC Neighborhood of PRKDC MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.505E-5 8.329E-4 5.615E-3 2.615E-2 13 174
30 module 277 Genes in module 277 MSigDb: C4 - CM: Cancer Modules 5.529E-5 8.329E-4 5.615E-3 2.626E-2 7 49
31 MORF DDB1 Neighborhood of DDB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.539E-5 8.329E-4 5.615E-3 2.631E-2 15 225
32 GCM SMARCC1 Neighborhood of SMARCC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.611E-5 8.329E-4 5.615E-3 2.665E-2 6 34
33 MORF GNB1 Neighborhood of GNB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.280E-5 9.039E-4 6.094E-3 2.983E-2 17 282
34 MORF PPP1CC Neighborhood of PPP1CC MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.687E-5 9.342E-4 6.298E-3 3.176E-2 12 153
35 module 98 Genes in module 98 MSigDb: C4 - CM: Cancer Modules 9.816E-5 1.332E-3 8.981E-3 4.662E-2 20 381
36 GCM MAP1B Neighborhood of MAP1B MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.323E-4 1.746E-3 1.177E-2
6.285E-2
 7 56
37 GNF2 KPNB1 Neighborhood of KPNB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.483E-4 1.903E-3 1.283E-2
7.043E-2
 7 57
38 GNF2 TDG Neighborhood of TDG MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.566E-4 1.958E-3 1.320E-2
7.441E-2
 5 26
39 GCM NF2 Neighborhood of NF2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.654E-4 1.968E-3 1.327E-2
7.856E-2
 15 248
40 GCM ERBB2IP Neighborhood of ERBB2IP MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.657E-4 1.968E-3 1.327E-2
7.873E-2
 7 58
41 MORF EIF4E Neighborhood of EIF4E MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.809E-4 2.096E-3 1.413E-2
8.594E-2
 8 78
42 MORF PAPSS1 Neighborhood of PAPSS1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.968E-4 2.226E-3 1.501E-2
9.350E-2
 9 100
43 MORF RAP1A Neighborhood of RAP1A MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.171E-4 2.398E-3 1.617E-2
1.031E-1
 10 124
44 MORF TERF2IP Neighborhood of TERF2IP MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.289E-4 2.471E-3 1.666E-2
1.087E-1
 9 102
45 GCM TPR Neighborhood of TPR MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.691E-4 2.840E-3 1.915E-2
1.278E-1
 5 29
46 module 198 Genes in module 198 MSigDb: C4 - CM: Cancer Modules 3.103E-4 3.204E-3 2.160E-2
1.474E-1
 16 292
47 module 352 Genes in module 352 MSigDb: C4 - CM: Cancer Modules 3.261E-4 3.295E-3 2.222E-2
1.549E-1
 4 17
48 module 229 Genes in module 229 MSigDb: C4 - CM: Cancer Modules 3.724E-4 3.635E-3 2.451E-2
1.769E-1
 5 31
49 module 72 Genes in module 72 MSigDb: C4 - CM: Cancer Modules 3.750E-4 3.635E-3 2.451E-2
1.781E-1
 16 297
50 GNF2 DEK Neighborhood of DEK MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.039E-4 3.837E-3 2.587E-2
1.918E-1
 6 48
Show 45 more annotations

16: MicroRNA [Display Chart] 1473 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-548m:PITA hsa-miR-548m:PITA TOP PITA 1.481E-14 2.181E-11 1.717E-10 2.181E-11 32 457
2 hsa-miR-653:PITA hsa-miR-653:PITA TOP PITA 5.841E-14 3.052E-11 2.403E-10 8.604E-11 26 306
3 hsa-miR-888:PITA hsa-miR-888:PITA TOP PITA 6.216E-14 3.052E-11 2.403E-10 9.156E-11 30 420
4 hsa-miR-802:PITA hsa-miR-802:PITA TOP PITA 4.190E-13 1.090E-10 8.579E-10 6.171E-10 30 452
5 hsa-miR-1264:PITA hsa-miR-1264:PITA TOP PITA 4.435E-13 1.090E-10 8.579E-10 6.533E-10 30 453
6 miR-199a-star:PicTar miR-199a-star:PicTar PicTar 4.439E-13 1.090E-10 8.579E-10 6.538E-10 29 422
7 hsa-miR-1278:PITA hsa-miR-1278:PITA TOP PITA 5.448E-13 1.146E-10 9.025E-10 8.024E-10 20 184
8 hsa-miR-101:PITA hsa-miR-101:PITA TOP PITA 1.847E-12 3.401E-10 2.677E-9 2.720E-9 30 479
9 hsa-miR-377:PITA hsa-miR-377:PITA TOP PITA 3.580E-12 5.859E-10 4.613E-9 5.273E-9 29 459
10 hsa-miR-194:PITA hsa-miR-194:PITA TOP PITA 1.347E-11 1.984E-9 1.562E-8 1.984E-8 22 271
11 hsa-miR-875-3p:PITA hsa-miR-875-3p:PITA TOP PITA 1.881E-11 2.472E-9 1.946E-8 2.771E-8 28 458
12 hsa-miR-380:PITA hsa-miR-380:PITA TOP PITA 2.396E-11 2.472E-9 1.946E-8 3.530E-8 26 398
13 TGAATGT,MIR-181A:MSigDB TGAATGT,MIR-181A:MSigDB MSigDB 2.685E-11 2.472E-9 1.946E-8 3.955E-8 28 465
14 TGAATGT,MIR-181D:MSigDB TGAATGT,MIR-181D:MSigDB MSigDB 2.685E-11 2.472E-9 1.946E-8 3.955E-8 28 465
15 TGAATGT,MIR-181B:MSigDB TGAATGT,MIR-181B:MSigDB MSigDB 2.685E-11 2.472E-9 1.946E-8 3.955E-8 28 465
16 TGAATGT,MIR-181C:MSigDB TGAATGT,MIR-181C:MSigDB MSigDB 2.685E-11 2.472E-9 1.946E-8 3.955E-8 28 465
17 hsa-miR-34b:PITA hsa-miR-34b:PITA TOP PITA 4.811E-11 3.955E-9 3.114E-8 7.087E-8 25 379
18 hsa-miR-892a:PITA hsa-miR-892a:PITA TOP PITA 5.078E-11 3.955E-9 3.114E-8 7.480E-8 21 262
19 hsa-miR-320c:PITA hsa-miR-320c:PITA TOP PITA 5.907E-11 3.955E-9 3.114E-8 8.701E-8 28 481
20 hsa-miR-320a:PITA hsa-miR-320a:PITA TOP PITA 5.907E-11 3.955E-9 3.114E-8 8.701E-8 28 481
21 hsa-miR-320b:PITA hsa-miR-320b:PITA TOP PITA 5.907E-11 3.955E-9 3.114E-8 8.701E-8 28 481
22 hsa-miR-320d:PITA hsa-miR-320d:PITA TOP PITA 5.907E-11 3.955E-9 3.114E-8 8.701E-8 28 481
23 hsa-miR-485-3p:PITA hsa-miR-485-3p:PITA TOP PITA 8.702E-11 5.573E-9 4.387E-8 1.282E-7 26 422
24 CTACTGT,MIR-199A:MSigDB CTACTGT,MIR-199A:MSigDB MSigDB 1.193E-10 7.323E-9 5.765E-8 1.757E-7 17 170
25 hsa-miR-543:TargetScan hsa-miR-543:TargetScan TargetScan 1.257E-10 7.409E-9 5.833E-8 1.852E-7 28 497
26 hsa-miR-624:PITA hsa-miR-624:PITA TOP PITA 1.341E-10 7.598E-9 5.981E-8 1.975E-7 21 276
27 miR-200b:PicTar miR-200b:PicTar PicTar 1.475E-10 7.884E-9 6.207E-8 2.172E-7 27 466
28 miR-200c:PicTar miR-200c:PicTar PicTar 1.547E-10 7.884E-9 6.207E-8 2.279E-7 27 467
29 hsa-miR-212:PITA hsa-miR-212:PITA TOP PITA 1.606E-10 7.884E-9 6.207E-8 2.365E-7 23 338
30 hsa-miR-132:PITA hsa-miR-132:PITA TOP PITA 1.606E-10 7.884E-9 6.207E-8 2.365E-7 23 338
31 hsa-miR-1252:PITA hsa-miR-1252:PITA TOP PITA 1.782E-10 8.467E-9 6.666E-8 2.625E-7 24 371
32 hsa-miR-646:PITA hsa-miR-646:PITA TOP PITA 1.860E-10 8.564E-9 6.742E-8 2.740E-7 26 437
33 hsa-miR-26b:PITA hsa-miR-26b:PITA TOP PITA 2.056E-10 8.652E-9 6.811E-8 3.028E-7 27 473
34 hsa-miR-26a:PITA hsa-miR-26a:PITA TOP PITA 2.056E-10 8.652E-9 6.811E-8 3.028E-7 27 473
35 hsa-miR-1297:PITA hsa-miR-1297:PITA TOP PITA 2.056E-10 8.652E-9 6.811E-8 3.028E-7 27 473
36 hsa-miR-544:PITA hsa-miR-544:PITA TOP PITA 2.379E-10 9.734E-9 7.664E-8 3.504E-7 26 442
37 hsa-miR-936:PITA hsa-miR-936:PITA TOP PITA 2.886E-10 1.149E-8 9.044E-8 4.251E-7 20 259
38 hsa-miR-139-5p:PITA hsa-miR-139-5p:PITA TOP PITA 3.167E-10 1.228E-8 9.664E-8 4.665E-7 22 319
39 hsa-miR-1290:PITA hsa-miR-1290:PITA TOP PITA 3.777E-10 1.393E-8 1.097E-7 5.564E-7 23 353
40 hsa-miR-603:PITA hsa-miR-603:PITA TOP PITA 3.783E-10 1.393E-8 1.097E-7 5.572E-7 24 385
41 hsa-miR-371-5p:PITA hsa-miR-371-5p:PITA TOP PITA 6.612E-10 2.375E-8 1.870E-7 9.739E-7 19 243
42 hsa-miR-410:PITA hsa-miR-410:PITA TOP PITA 6.876E-10 2.411E-8 1.898E-7 1.013E-6 23 364
43 hsa-miR-489:PITA hsa-miR-489:PITA TOP PITA 8.032E-10 2.598E-8 2.045E-7 1.183E-6 17 192
44 CTTGTAT,MIR-381:MSigDB CTTGTAT,MIR-381:MSigDB MSigDB 8.032E-10 2.598E-8 2.045E-7 1.183E-6 17 192
45 CAGTATT,MIR-429:MSigDB CAGTATT,MIR-429:MSigDB MSigDB 8.290E-10 2.598E-8 2.045E-7 1.221E-6 25 434
46 CAGTATT,MIR-200C:MSigDB CAGTATT,MIR-200C:MSigDB MSigDB 8.290E-10 2.598E-8 2.045E-7 1.221E-6 25 434
47 CAGTATT,MIR-200B:MSigDB CAGTATT,MIR-200B:MSigDB MSigDB 8.290E-10 2.598E-8 2.045E-7 1.221E-6 25 434
48 miR-302c-star:PicTar miR-302c-star:PicTar PicTar 9.948E-10 3.053E-8 2.403E-7 1.465E-6 23 371
49 hsa-miR-767-5p:PITA hsa-miR-767-5p:PITA TOP PITA 1.066E-9 3.206E-8 2.524E-7 1.571E-6 20 279
50 hsa-miR-935:PITA hsa-miR-935:PITA TOP PITA 1.285E-9 3.784E-8 2.979E-7 1.892E-6 20 282
Show 45 more annotations

17: Drug [Display Chart] 19303 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 985 DN ICI 182,780; Down 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP 3.726E-35 4.493E-31 4.693E-30 7.192E-31 37 177
2 3998 DN Etifenin [63245-28-3]; Down 200; 12.4uM; PC3; HT HG-U133A Broad Institute CMAP 4.656E-35 4.493E-31 4.693E-30 8.987E-31 37 178
3 3887 DN Camptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.348E-30 8.671E-27 9.057E-26 2.601E-26 34 182
4 4585 DN Captopril [62571-86-2]; Down 200; 17.2uM; PC3; HT HG-U133A Broad Institute CMAP 6.655E-27 3.211E-23 3.354E-22 1.285E-22 31 179
5 2321 DN Camptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.607E-26 6.202E-23 6.479E-22 3.101E-22 31 184
6 1114 DN tyrphostin AG-825; Down 200; 25.2uM; MCF7; HT HG-U133A EA Broad Institute CMAP 3.502E-25 1.127E-21 1.177E-20 6.760E-21 30 185
7 4541 DN Camptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; PC3; HT HG-U133A Broad Institute CMAP 2.735E-24 7.543E-21 7.879E-20 5.280E-20 29 180
8 6735 DN Neostigmine bromide [114-80-7]; Down 200; 13.2uM; PC3; HT HG-U133A Broad Institute CMAP 9.878E-24 2.383E-20 2.490E-19 1.907E-19 29 188
9 D003010 Clorgyline CTD 1.188E-22 2.547E-19 2.661E-18 2.292E-18 27 168
10 4283 DN Phenformin hydrochloride [834-28-6]; Down 200; 16.6uM; PC3; HT HG-U133A Broad Institute CMAP 2.545E-22 4.912E-19 5.131E-18 4.912E-18 28 191
11 7498 DN irinotecan HCl; Down 200; 100uM; MCF7; HT HG-U133A Broad Institute CMAP 1.915E-20 3.360E-17 3.510E-16 3.696E-16 26 183
12 C001277 geldanamycin CTD 2.275E-20 3.659E-17 3.822E-16 4.391E-16 34 366
13 4303 DN Flunisolide [3385-03-3]; Down 200; 9.2uM; PC3; HT HG-U133A Broad Institute CMAP 5.807E-20 8.623E-17 9.007E-16 1.121E-15 26 191
14 4307 DN Pempidine tartrate [546-48-5]; Down 200; 13uM; PC3; HT HG-U133A Broad Institute CMAP 7.179E-19 9.898E-16 1.034E-14 1.386E-14 25 190
15 4312 DN Benfotiamine [22457-89-2]; Down 200; 8.6uM; PC3; HT HG-U133A Broad Institute CMAP 1.200E-18 1.544E-15 1.613E-14 2.317E-14 25 194
16 1673 DN Sulfaphenazole [526-08-9]; Down 200; 12.8uM; MCF7; HT HG-U133A Broad Institute CMAP 5.156E-18 6.220E-15 6.497E-14 9.952E-14 24 185
17 4306 DN Deltaline [6836-11-9]; Down 200; 7.8uM; PC3; HT HG-U133A Broad Institute CMAP 9.676E-18 1.099E-14 1.148E-13 1.868E-13 24 190
18 C483909 torcetrapib CTD 6.282E-17 6.736E-14 7.036E-13 1.213E-12 29 328
19 4302 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 8.674E-17 8.813E-14 9.205E-13 1.674E-12 23 187
20 1045 DN Rapamycin; Down 200; 0.1uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.102E-16 1.063E-13 1.110E-12 2.126E-12 23 189
21 4268 DN Meclofenoxate hydrochloride [3685-84-5]; Down 200; 13.6uM; PC3; HT HG-U133A Broad Institute CMAP 1.568E-16 1.375E-13 1.437E-12 3.026E-12 23 192
22 4311 DN N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; PC3; HT HG-U133A Broad Institute CMAP 1.568E-16 1.375E-13 1.437E-12 3.026E-12 23 192
23 6020 DN Diphenhydramine hydrochloride [147-24-0]; Down 200; 13.8uM; MCF7; HT HG-U133A Broad Institute CMAP 1.686E-15 1.415E-12 1.478E-11 3.254E-11 22 191
24 1769 DN Ipratropium bromide [22254-24-6]; Down 200; 9.8uM; HL60; HG-U133A Broad Institute CMAP 1.562E-14 1.160E-11 1.211E-10 3.015E-10 21 189
25 4304 DN Mepenzolate bromide [76-90-4]; Down 200; 9.6uM; PC3; HT HG-U133A Broad Institute CMAP 1.562E-14 1.160E-11 1.211E-10 3.015E-10 21 189
26 4271 DN Cloperastine hydrochloride [14984-68-0]; Down 200; 11uM; PC3; HT HG-U133A Broad Institute CMAP 1.562E-14 1.160E-11 1.211E-10 3.015E-10 21 189
27 4269 DN Norgestrel-(-)-D [797-63-7]; Down 200; 12.8uM; PC3; HT HG-U133A Broad Institute CMAP 2.145E-14 1.533E-11 1.602E-10 4.140E-10 21 192
28 7530 DN irinotecan HCl; Down 200; 100uM; MCF7; HT HG-U133A Broad Institute CMAP 3.503E-14 2.415E-11 2.523E-10 6.763E-10 20 174
29 4310 DN Dipyrone [5907-38-0]; Down 200; 12uM; PC3; HT HG-U133A Broad Institute CMAP 1.547E-13 1.030E-10 1.075E-9 2.986E-9 20 188
30 1288 DN Flupentixol dihydrochloride cis-(Z) [2413-38-9]; Down 200; 7.8uM; HL60; HT HG-U133A Broad Institute CMAP 1.711E-13 1.101E-10 1.150E-9 3.304E-9 20 189
31 4273 DN Flunixin meglumine [42461-84-7]; Down 200; 8.2uM; PC3; HT HG-U133A Broad Institute CMAP 2.091E-13 1.302E-10 1.360E-9 4.036E-9 20 191
32 4274 DN Fenoprofen calcium salt dihydrate [53746-45-5]; Down 200; 7.2uM; PC3; HT HG-U133A Broad Institute CMAP 2.309E-13 1.393E-10 1.455E-9 4.458E-9 20 192
33 4279 DN Fenbufen [36330-85-5]; Down 200; 15.8uM; PC3; HT HG-U133A Broad Institute CMAP 2.549E-13 1.491E-10 1.557E-9 4.920E-9 20 193
34 6159 DN Cefepime hydrochloride [123171-59-5]; Down 200; 7.4uM; HL60; HT HG-U133A Broad Institute CMAP 3.099E-13 1.709E-10 1.785E-9 5.982E-9 20 195
35 4309 DN Famprofazone [22881-35-2]; Down 200; 10.6uM; PC3; HT HG-U133A Broad Institute CMAP 3.099E-13 1.709E-10 1.785E-9 5.982E-9 20 195
36 C058305 phenethyl isothiocyanate CTD 3.670E-13 1.961E-10 2.049E-9 7.084E-9 27 393
37 164 DN R(+)-verapamil hydrochloride; Down 200; 10uM; MCF7; HG-U133A Broad Institute CMAP 3.760E-13 1.961E-10 2.049E-9 7.257E-9 20 197
38 7085 DN GW8510; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 8.972E-13 4.557E-10 4.760E-9 1.732E-8 19 182
39 4321 DN Ethoxyquin [91-53-2]; Down 200; 18.4uM; PC3; HT HG-U133A Broad Institute CMAP 2.574E-12 1.274E-9 1.331E-8 4.969E-8 19 193
40 1985 DN Isoxsuprine hydrochloride [579-56-6]; Down 200; 11.8uM; HL60; HG-U133A Broad Institute CMAP 3.095E-12 1.447E-9 1.511E-8 5.973E-8 19 195
41 4272 DN Flumethasone [2135-17-3]; Down 200; 9.8uM; PC3; HT HG-U133A Broad Institute CMAP 3.095E-12 1.447E-9 1.511E-8 5.973E-8 19 195
42 7535 DN irinotecan HCl; Down 200; 100uM; PC3; HT HG-U133A Broad Institute CMAP 3.148E-12 1.447E-9 1.511E-8 6.077E-8 18 171
43 4404 UP Proscillaridin A [466-06-8]; Up 200; 7.6uM; MCF7; HT HG-U133A Broad Institute CMAP 1.101E-11 4.943E-9 5.164E-8 2.126E-7 17 160
44 3075 DN Cantharidin [56-25-7]; Down 200; 20.4uM; HL60; HT HG-U133A Broad Institute CMAP 1.439E-11 6.314E-9 6.595E-8 2.778E-7 18 187
45 4845 DN Primaquine diphosphate [63-45-6]; Down 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP 1.575E-11 6.754E-9 7.055E-8 3.039E-7 18 188
46 3926 DN Pempidine tartrate [546-48-5]; Down 200; 13uM; MCF7; HT HG-U133A Broad Institute CMAP 2.055E-11 8.624E-9 9.008E-8 3.967E-7 18 191
47 1741 DN Laudanosine (R,S) [1699-51-0]; Down 200; 11.2uM; HL60; HG-U133A Broad Institute CMAP 2.669E-11 1.051E-8 1.098E-7 5.152E-7 18 194
48 4361 DN Flutamide [13311-84-7]; Down 200; 14.4uM; MCF7; HT HG-U133A Broad Institute CMAP 2.669E-11 1.051E-8 1.098E-7 5.152E-7 18 194
49 4308 DN Promazine hydrochloride [53-60-1]; Down 200; 12.4uM; PC3; HT HG-U133A Broad Institute CMAP 2.669E-11 1.051E-8 1.098E-7 5.152E-7 18 194
50 3297 UP Bisacodyl [603-50-9]; Up 200; 11uM; MCF7; HT HG-U133A Broad Institute CMAP 3.212E-11 1.240E-8 1.295E-7 6.201E-7 17 171
Show 45 more annotations

18: Disease [Display Chart] 1996 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C3714756 Intellectual Disability DisGeNET Curated 6.550E-7 1.307E-3 1.069E-2 1.307E-3 21 413
2 umls:C2939461 Myeloid neoplasm DisGeNET BeFree 1.321E-6 1.318E-3 1.078E-2 2.636E-3 9 75
3 umls:C1318551 Refractory anemia with excess blasts II DisGeNET BeFree 5.113E-6 3.402E-3 2.781E-2 1.020E-2 4 9
4 umls:C0010606 Adenoid Cystic Carcinoma DisGeNET Curated 1.657E-5 8.269E-3
6.761E-2
 3.308E-2 12 185
5 umls:C2826330 Refractory anemia with ring sideroblasts associated with marked thrombocytosis DisGeNET BeFree 2.939E-5 1.173E-2
9.594E-2
5.867E-2
 3 5
6 umls:C1292772 Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative DisGeNET Curated 5.469E-5 1.820E-2
1.488E-1
1.092E-1
 5 29
7 umls:C0376545 Hematologic Neoplasms DisGeNET Curated 6.474E-5 1.827E-2
1.494E-1
1.292E-1
 18 434
8 umls:C0005699 Blast Phase DisGeNET Curated 7.909E-5 1.827E-2
1.494E-1
1.579E-1
 12 217
9 umls:C0013421 Dystonia DisGeNET Curated 9.140E-5 1.827E-2
1.494E-1
1.824E-1
 9 126
10 umls:C3279664 Emberger syndrome DisGeNET Curated 1.007E-4 1.827E-2
1.494E-1
2.010E-1
 3 7
11 umls:C0280028 Refractory anemia with excess blasts in transformation (clinical) DisGeNET BeFree 1.007E-4 1.827E-2
1.494E-1
2.010E-1
 3 7
12 umls:C0270972 Cornelia De Lange Syndrome DisGeNET Curated 2.559E-4 4.257E-2
3.480E-1
5.108E-1
 4 22
Show 7 more annotations