Toppgene analysis for aggregated_1964_log, IC8, positive side

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1: GO: Molecular Function [Display Chart] 711 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003779 actin binding 2.034E-24 1.446E-21 1.033E-20 1.446E-21 43 412
2 GO:0008307 structural constituent of muscle 4.042E-13 1.437E-10 1.027E-9 2.874E-10 12 41
3 GO:0050840 extracellular matrix binding 8.893E-9 2.108E-6 1.506E-5 6.323E-6 10 57
4 GO:0051015 actin filament binding 8.551E-8 1.520E-5 1.086E-4 6.079E-5 13 134
5 GO:0005523 tropomyosin binding 1.155E-6 1.642E-4 1.173E-3 8.211E-4 5 14
6 GO:0005178 integrin binding 1.778E-6 2.107E-4 1.505E-3 1.264E-3 11 122
7 GO:0051371 muscle alpha-actinin binding 5.306E-6 5.390E-4 3.851E-3 3.773E-3 4 9
8 GO:0043236 laminin binding 6.071E-6 5.396E-4 3.855E-3 4.317E-3 6 32
9 GO:0042805 actinin binding 1.243E-5 9.264E-4 6.619E-3 8.834E-3 6 36
10 GO:0050839 cell adhesion molecule binding 1.303E-5 9.264E-4 6.619E-3 9.264E-3 13 209
11 GO:0005516 calmodulin binding 2.541E-5 1.592E-3 1.137E-2 1.806E-2 12 191
12 GO:0051393 alpha-actinin binding 2.686E-5 1.592E-3 1.137E-2 1.910E-2 5 25
13 GO:0097493 structural molecule activity conferring elasticity 1.637E-4 8.954E-3
6.397E-2
1.164E-1
3 8
14 GO:0050998 nitric-oxide synthase binding 2.652E-4 1.347E-2
9.622E-2
1.885E-1
4 22
15 GO:0030674 protein binding, bridging 7.032E-4 3.333E-2
2.381E-1
5.000E-1
9 164
16 GO:0019838 growth factor binding 1.167E-3 4.648E-2
3.321E-1
8.296E-1
8 142
17 GO:0005200 structural constituent of cytoskeleton 1.229E-3 4.648E-2
3.321E-1
8.741E-1
7 111
18 GO:0070052 collagen V binding 1.252E-3 4.648E-2
3.321E-1
8.902E-1
2 4
19 GO:0031014 troponin T binding 1.252E-3 4.648E-2
3.321E-1
8.902E-1
2 4
20 GO:0001786 phosphatidylserine binding 1.308E-3 4.648E-2
3.321E-1
9.297E-1
4 33
21 GO:0060090 binding, bridging 1.464E-3 4.957E-2
3.541E-1
1.000E0
9 182
Show 16 more annotations

2: GO: Biological Process [Display Chart] 3859 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0060537 muscle tissue development 4.874E-33 1.221E-29 1.078E-28 1.881E-29 52 419
2 GO:0014706 striated muscle tissue development 6.326E-33 1.221E-29 1.078E-28 2.441E-29 51 401
3 GO:0007517 muscle organ development 2.156E-31 2.774E-28 2.451E-27 8.321E-28 50 410
4 GO:0055001 muscle cell development 4.851E-24 4.680E-21 4.135E-20 1.872E-20 31 183
5 GO:0042692 muscle cell differentiation 3.514E-23 2.712E-20 2.396E-19 1.356E-19 42 415
6 GO:0055002 striated muscle cell development 8.622E-23 5.545E-20 4.899E-19 3.327E-19 29 168
7 GO:0003012 muscle system process 1.830E-22 1.009E-19 8.912E-19 7.060E-19 42 433
8 GO:0051146 striated muscle cell differentiation 6.914E-21 3.335E-18 2.947E-17 2.668E-17 34 291
9 GO:0030049 muscle filament sliding 1.482E-19 6.353E-17 5.613E-16 5.717E-16 16 40
10 GO:0033275 actin-myosin filament sliding 2.398E-19 8.570E-17 7.572E-16 9.254E-16 16 41
11 GO:0006936 muscle contraction 2.443E-19 8.570E-17 7.572E-16 9.427E-16 35 348
12 GO:0070252 actin-mediated cell contraction 1.816E-18 5.839E-16 5.159E-15 7.007E-15 21 102
13 GO:0007519 skeletal muscle tissue development 8.312E-18 2.467E-15 2.180E-14 3.207E-14 26 192
14 GO:0060538 skeletal muscle organ development 2.994E-17 8.252E-15 7.291E-14 1.155E-13 26 202
15 GO:0030048 actin filament-based movement 1.479E-16 3.806E-14 3.363E-13 5.709E-13 21 125
16 GO:0048738 cardiac muscle tissue development 1.596E-16 3.848E-14 3.400E-13 6.158E-13 26 216
17 GO:0030239 myofibril assembly 4.822E-16 1.095E-13 9.671E-13 1.861E-12 16 62
18 GO:0045214 sarcomere organization 1.434E-14 3.074E-12 2.716E-11 5.533E-11 13 41
19 GO:0006941 striated muscle contraction 3.071E-12 6.238E-10 5.511E-9 1.185E-8 19 161
20 GO:0003007 heart morphogenesis 2.533E-11 4.887E-9 4.318E-8 9.775E-8 22 252
21 GO:0031032 actomyosin structure organization 3.979E-11 7.312E-9 6.460E-8 1.535E-7 18 164
22 GO:0060415 muscle tissue morphogenesis 4.612E-11 8.089E-9 7.147E-8 1.780E-7 13 73
23 GO:0035914 skeletal muscle cell differentiation 9.320E-11 1.564E-8 1.382E-7 3.597E-7 13 77
24 GO:0090257 regulation of muscle system process 1.193E-10 1.918E-8 1.695E-7 4.603E-7 20 222
25 GO:0048644 muscle organ morphogenesis 1.807E-10 2.789E-8 2.464E-7 6.972E-7 13 81
26 GO:0048747 muscle fiber development 2.021E-10 2.999E-8 2.650E-7 7.798E-7 12 66
27 GO:0003208 cardiac ventricle morphogenesis 5.830E-10 8.332E-8 7.362E-7 2.250E-6 12 72
28 GO:0071559 response to transforming growth factor beta 2.186E-9 3.013E-7 2.663E-6 8.438E-6 19 235
29 GO:0006937 regulation of muscle contraction 2.828E-9 3.763E-7 3.325E-6 1.091E-5 16 164
30 GO:0030198 extracellular matrix organization 3.088E-9 3.972E-7 3.510E-6 1.192E-5 23 354
31 GO:0043062 extracellular structure organization 3.259E-9 4.057E-7 3.584E-6 1.258E-5 23 355
32 GO:0060048 cardiac muscle contraction 3.416E-9 4.119E-7 3.639E-6 1.318E-5 14 122
33 GO:0060047 heart contraction 5.438E-9 6.339E-7 5.600E-6 2.099E-5 20 276
34 GO:0048641 regulation of skeletal muscle tissue development 5.585E-9 6.339E-7 5.600E-6 2.155E-5 10 54
35 GO:0003015 heart process 6.540E-9 7.211E-7 6.371E-6 2.524E-5 20 279
36 GO:0071560 cellular response to transforming growth factor beta stimulus 1.045E-8 1.098E-6 9.703E-6 4.034E-5 18 231
37 GO:0003009 skeletal muscle contraction 1.053E-8 1.098E-6 9.703E-6 4.063E-5 9 43
38 GO:0007160 cell-matrix adhesion 1.152E-8 1.170E-6 1.033E-5 4.444E-5 17 206
39 GO:0055008 cardiac muscle tissue morphogenesis 2.654E-8 2.626E-6 2.320E-5 1.024E-4 10 63
40 GO:0003206 cardiac chamber morphogenesis 2.795E-8 2.696E-6 2.382E-5 1.078E-4 13 121
41 GO:0010927 cellular component assembly involved in morphogenesis 3.329E-8 3.133E-6 2.768E-5 1.285E-4 21 338
42 GO:0035051 cardiocyte differentiation 3.512E-8 3.227E-6 2.851E-5 1.355E-4 14 146
43 GO:0014902 myotube differentiation 3.757E-8 3.371E-6 2.979E-5 1.450E-4 13 124
44 GO:0032970 regulation of actin filament-based process 4.283E-8 3.701E-6 3.270E-5 1.653E-4 21 343
45 GO:0043500 muscle adaptation 4.316E-8 3.701E-6 3.270E-5 1.665E-4 12 104
46 GO:0016202 regulation of striated muscle tissue development 4.554E-8 3.820E-6 3.375E-5 1.757E-4 13 126
47 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 4.809E-8 3.867E-6 3.416E-5 1.856E-4 12 105
48 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 4.809E-8 3.867E-6 3.416E-5 1.856E-4 12 105
49 GO:0003231 cardiac ventricle development 5.007E-8 3.943E-6 3.484E-5 1.932E-4 13 127
50 GO:0007015 actin filament organization 5.221E-8 4.030E-6 3.560E-5 2.015E-4 21 347
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 328 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0044449 contractile fiber part 1.493E-32 4.784E-30 3.048E-29 4.898E-30 40 216
2 GO:0043292 contractile fiber 2.917E-32 4.784E-30 3.048E-29 9.568E-30 41 235
3 GO:0030016 myofibril 1.086E-29 1.188E-27 7.568E-27 3.563E-27 38 221
4 GO:0030017 sarcomere 5.640E-29 4.625E-27 2.947E-26 1.850E-26 36 199
5 GO:0031674 I band 8.045E-22 5.277E-20 3.363E-19 2.639E-19 26 136
6 GO:0015629 actin cytoskeleton 5.836E-21 3.191E-19 2.033E-18 1.914E-18 42 478
7 GO:0030018 Z disc 3.190E-18 1.495E-16 9.523E-16 1.046E-15 22 120
8 GO:0005912 adherens junction 2.753E-11 1.129E-9 7.192E-9 9.029E-9 30 484
9 GO:0005865 striated muscle thin filament 4.427E-11 1.613E-9 1.028E-8 1.452E-8 9 25
10 GO:0030055 cell-substrate junction 5.004E-11 1.641E-9 1.046E-8 1.641E-8 27 403
11 GO:0005924 cell-substrate adherens junction 2.013E-10 5.636E-9 3.591E-8 6.603E-8 26 398
12 GO:0036379 myofilament 2.062E-10 5.636E-9 3.591E-8 6.764E-8 9 29
13 GO:0005925 focal adhesion 7.932E-10 2.001E-8 1.275E-7 2.602E-7 25 393
14 GO:0098858 actin-based cell projection 1.469E-9 3.442E-8 2.193E-7 4.819E-7 18 206
15 GO:0030027 lamellipodium 2.133E-9 4.665E-8 2.973E-7 6.998E-7 17 186
16 GO:0005911 cell-cell junction 3.093E-9 6.206E-8 3.954E-7 1.014E-6 25 420
17 GO:0031252 cell leading edge 3.216E-9 6.206E-8 3.954E-7 1.055E-6 24 389
18 GO:0030175 filopodium 3.126E-8 5.697E-7 3.630E-6 1.025E-5 12 102
19 GO:0005859 muscle myosin complex 3.002E-7 5.182E-6 3.302E-5 9.846E-5 6 20
20 GO:0016010 dystrophin-associated glycoprotein complex 5.638E-7 8.806E-6 5.611E-5 1.849E-4 6 22
21 GO:0090665 glycoprotein complex 5.638E-7 8.806E-6 5.611E-5 1.849E-4 6 22
22 GO:0016459 myosin complex 6.168E-7 9.195E-6 5.859E-5 2.023E-4 9 68
23 GO:0098794 postsynapse 9.813E-7 1.399E-5 8.916E-5 3.219E-4 22 454
24 GO:0016460 myosin II complex 2.104E-6 2.875E-5 1.832E-4 6.900E-4 6 27
25 GO:0042383 sarcolemma 2.640E-6 3.463E-5 2.207E-4 8.659E-4 12 153
26 GO:0005861 troponin complex 2.977E-6 3.755E-5 2.393E-4 9.764E-4 4 8
27 GO:0044420 extracellular matrix component 8.327E-6 1.012E-4 6.445E-4 2.731E-3 11 143
28 GO:0045121 membrane raft 1.288E-5 1.456E-4 9.279E-4 4.223E-3 17 343
29 GO:0098857 membrane microdomain 1.288E-5 1.456E-4 9.279E-4 4.223E-3 17 343
30 GO:0031091 platelet alpha granule 1.355E-5 1.481E-4 9.439E-4 4.444E-3 8 75
31 GO:0031594 neuromuscular junction 2.924E-5 3.094E-4 1.971E-3 9.591E-3 7 61
32 GO:0031012 extracellular matrix 3.115E-5 3.193E-4 2.035E-3 1.022E-2 19 444
33 GO:0005578 proteinaceous extracellular matrix 4.568E-5 4.540E-4 2.893E-3 1.498E-2 17 379
34 GO:0005901 caveola 8.179E-5 7.890E-4 5.027E-3 2.683E-2 8 96
35 GO:0032432 actin filament bundle 1.026E-4 9.156E-4 5.834E-3 3.366E-2 7 74
36 GO:0016528 sarcoplasm 1.026E-4 9.156E-4 5.834E-3 3.366E-2 7 74
37 GO:0016011 dystroglycan complex 1.033E-4 9.156E-4 5.834E-3 3.388E-2 3 7
38 GO:0060076 excitatory synapse 1.147E-4 9.904E-4 6.311E-3 3.764E-2 13 258
39 GO:0042641 actomyosin 1.434E-4 1.199E-3 7.642E-3 4.703E-2 7 78
40 GO:0031093 platelet alpha granule lumen 1.463E-4 1.199E-3 7.642E-3 4.798E-2 6 55
41 GO:0044853 plasma membrane raft 1.536E-4 1.229E-3 7.830E-3
5.038E-2
8 105
42 GO:0005938 cell cortex 1.612E-4 1.247E-3 7.945E-3
5.288E-2
13 267
43 GO:0030314 junctional membrane complex 1.635E-4 1.247E-3 7.945E-3
5.362E-2
3 8
44 GO:0014069 postsynaptic density 2.081E-4 1.517E-3 9.663E-3
6.825E-2
12 238
45 GO:0099572 postsynaptic specialization 2.081E-4 1.517E-3 9.663E-3
6.825E-2
12 238
46 GO:0005604 basement membrane 2.256E-4 1.609E-3 1.025E-2
7.401E-2
8 111
47 GO:0034774 secretory granule lumen 2.456E-4 1.714E-3 1.092E-2
8.057E-2
7 85
48 GO:0032982 myosin filament 3.168E-4 2.165E-3 1.379E-2
1.039E-1
4 23
49 GO:0014701 junctional sarcoplasmic reticulum membrane 3.428E-4 2.294E-3 1.462E-2
1.124E-1
3 10
50 GO:0031672 A band 3.919E-4 2.571E-3 1.638E-2
1.285E-1
5 43
Show 45 more annotations

4: Human Phenotype [Display Chart] 1037 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0001644 Dilated cardiomyopathy 1.715E-11 1.779E-8 1.338E-7 1.779E-8 16 87
2 HP:0003391 Gowers sign 3.448E-9 1.343E-6 1.010E-5 3.576E-6 10 38
3 HP:0001638 Cardiomyopathy 4.853E-9 1.343E-6 1.010E-5 5.032E-6 13 77
4 HP:0002747 Respiratory insufficiency due to muscle weakness 5.701E-9 1.343E-6 1.010E-5 5.912E-6 12 64
5 HP:0010628 Facial palsy 6.477E-9 1.343E-6 1.010E-5 6.717E-6 14 94
6 HP:0001699 Sudden death 8.454E-9 1.461E-6 1.099E-5 8.767E-6 9 31
7 HP:0000467 Neck muscle weakness {has synonym type="layperson"} 1.190E-8 1.763E-6 1.326E-5 1.234E-5 8 23
8 HP:0003560 Muscular dystrophy 9.027E-8 1.170E-5 8.801E-5 9.361E-5 10 52
9 HP:0003458 EMG: myopathic abnormalities 1.665E-7 1.918E-5 1.443E-4 1.727E-4 8 31
10 HP:0003324 Generalized muscle weakness 3.636E-7 3.770E-5 2.836E-4 3.770E-4 8 34
11 HP:0001612 Weak cry 4.112E-7 3.877E-5 2.916E-4 4.264E-4 7 24
12 HP:0003236 Elevated serum creatine phosphokinase {has synonym type="layperson"} 6.345E-7 5.484E-5 4.125E-4 6.580E-4 14 134
13 HP:0001283 Bulbar palsy 1.700E-6 1.356E-4 1.020E-3 1.763E-3 7 29
14 HP:0030682 Left ventricular noncompaction 6.802E-6 5.038E-4 3.790E-3 7.054E-3 5 14
15 HP:0002515 Waddling gait 8.125E-6 5.617E-4 4.225E-3 8.426E-3 8 50
16 HP:0003443 Decreased size of nerve terminals 1.270E-5 8.231E-4 6.191E-3 1.317E-2 4 8
17 HP:0003701 Proximal muscle weakness 1.948E-5 1.189E-3 8.940E-3 2.021E-2 9 73
18 HP:0003445 EMG: neuropathic changes 3.630E-5 1.533E-3 1.153E-2 3.765E-2 5 19
19 HP:0002804 Arthrogryposis multiplex congenita 3.677E-5 1.533E-3 1.153E-2 3.813E-2 8 61
20 HP:0002600 Hyporeflexia of lower limbs 3.687E-5 1.533E-3 1.153E-2 3.823E-2 4 10
21 HP:0003798 Nemaline bodies 3.687E-5 1.533E-3 1.153E-2 3.823E-2 4 10
22 HP:0003555 Muscle fiber splitting 3.687E-5 1.533E-3 1.153E-2 3.823E-2 4 10
23 HP:0002047 Malignant hyperthermia 3.687E-5 1.533E-3 1.153E-2 3.823E-2 4 10
24 HP:0002647 Aortic dissection 3.695E-5 1.533E-3 1.153E-2 3.832E-2 3 4
25 HP:0003044 Shoulder flexion contracture 3.695E-5 1.533E-3 1.153E-2 3.832E-2 3 4
26 HP:0011675 Arrhythmia 4.148E-5 1.655E-3 1.245E-2 4.302E-2 8 62
27 HP:0002650 Scoliosis 4.429E-5 1.701E-3 1.279E-2 4.592E-2 19 328
28 HP:0002093 Respiratory insufficiency 5.536E-5 2.038E-3 1.533E-2
5.740E-2
9 83
29 HP:0003803 Type 1 muscle fiber predominance 5.699E-5 2.038E-3 1.533E-2
5.910E-2
4 11
30 HP:0001712 Left ventricular hypertrophy 8.167E-5 2.823E-3 2.123E-2
8.469E-2
8 68
31 HP:0006673 Reduced systolic function 9.096E-5 3.043E-3 2.289E-2
9.432E-2
3 5
32 HP:0001548 Overgrowth 9.819E-5 3.085E-3 2.321E-2
1.018E-1
5 23
33 HP:0000883 Thin ribs {has synonym type="layperson"} 9.819E-5 3.085E-3 2.321E-2
1.018E-1
5 23
34 HP:0003554 Type 2 muscle fiber atrophy 1.195E-4 3.613E-3 2.718E-2
1.239E-1
4 13
35 HP:0003388 Easy fatigability 1.219E-4 3.613E-3 2.718E-2
1.265E-1
5 24
36 HP:0005110 Atrial fibrillation 1.272E-4 3.664E-3 2.756E-2
1.319E-1
6 38
37 HP:0001635 Congestive heart failure 1.407E-4 3.943E-3 2.966E-2
1.459E-1
10 115
38 HP:0001270 Motor delay 1.498E-4 4.089E-3 3.075E-2
1.554E-1
15 242
39 HP:0000218 High palate {has synonym type="layperson"} 1.569E-4 4.172E-3 3.138E-2
1.627E-1
15 243
40 HP:0001670 Asymmetric septal hypertrophy 1.646E-4 4.266E-3 3.209E-2
1.706E-1
4 14
41 HP:0003707 Calf muscle pseudohypertrophy 1.791E-4 4.530E-3 3.407E-2
1.857E-1
3 6
42 HP:0001319 Neonatal hypotonia 2.037E-4 5.030E-3 3.784E-2
2.113E-1
9 98
43 HP:0000508 Ptosis 2.101E-4 5.066E-3 3.811E-2
2.179E-1
16 278
44 HP:0001558 Decreased fetal movement 2.175E-4 5.127E-3 3.856E-2
2.256E-1
8 78
45 HP:0001682 Subaortic stenosis 2.896E-4 6.527E-3 4.910E-2
3.003E-1
4 16
46 HP:0003473 Fatigable weakness 2.896E-4 6.527E-3 4.910E-2
3.003E-1
4 16
47 HP:0006277 Pancreatic hyperplasia 3.086E-4 6.531E-3 4.912E-2
3.200E-1
3 7
48 HP:0003247 Overgrowth of external genitalia {has synonym type="layperson"} 3.086E-4 6.531E-3 4.912E-2
3.200E-1
3 7
49 HP:0008186 Adrenocortical cytomegaly 3.086E-4 6.531E-3 4.912E-2
3.200E-1
3 7
50 HP:0000597 Ophthalmoparesis 3.725E-4 7.726E-3
5.811E-2
3.863E-1
4 17
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 3336 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004087 abnormal muscle fiber morphology 2.509E-20 8.371E-17 7.274E-16 8.371E-17 46 427
2 MP:0003084 abnormal skeletal muscle fiber morphology 3.911E-17 6.524E-14 5.669E-13 1.305E-13 31 220
3 MP:0000759 abnormal skeletal muscle morphology 2.129E-16 2.367E-13 2.057E-12 7.101E-13 42 446
4 MP:0009398 abnormal skeletal muscle fiber size 1.164E-14 9.704E-12 8.433E-11 3.882E-11 24 151
5 MP:0009403 increased variability of skeletal muscle fiber size 3.541E-12 2.208E-9 1.919E-8 1.181E-8 14 53
6 MP:0009404 centrally nucleated skeletal muscle fibers 3.972E-12 2.208E-9 1.919E-8 1.325E-8 17 88
7 MP:0004817 abnormal skeletal muscle mass 1.095E-11 5.218E-9 4.534E-8 3.653E-8 21 153
8 MP:0005620 abnormal muscle contractility 1.857E-11 7.743E-9 6.729E-8 6.195E-8 33 398
9 MP:0009399 increased skeletal muscle fiber size 2.463E-11 9.128E-9 7.932E-8 8.215E-8 12 40
10 MP:0009458 abnormal skeletal muscle size 4.176E-10 1.393E-7 1.211E-6 1.393E-6 15 87
11 MP:0004819 decreased skeletal muscle mass 5.705E-10 1.730E-7 1.503E-6 1.903E-6 18 135
12 MP:0000738 impaired muscle contractility 6.434E-10 1.789E-7 1.554E-6 2.146E-6 27 313
13 MP:0003852 skeletal muscle necrosis 1.150E-9 2.952E-7 2.565E-6 3.838E-6 11 43
14 MP:0003141 cardiac fibrosis 1.991E-9 4.745E-7 4.123E-6 6.643E-6 20 182
15 MP:0005329 abnormal myocardium layer morphology 2.213E-9 4.922E-7 4.277E-6 7.383E-6 32 452
16 MP:0003921 abnormal heart left ventricle morphology 3.083E-9 6.328E-7 5.499E-6 1.028E-5 26 313
17 MP:0010630 abnormal cardiac muscle tissue morphology 3.287E-9 6.328E-7 5.499E-6 1.096E-5 27 337
18 MP:0010545 abnormal heart layer morphology 3.414E-9 6.328E-7 5.499E-6 1.139E-5 32 460
19 MP:0000751 myopathy 8.189E-9 1.438E-6 1.249E-5 2.732E-5 11 51
20 MP:0000752 dystrophic muscle 1.434E-8 2.393E-6 2.079E-5 4.785E-5 10 42
21 MP:0009400 decreased skeletal muscle fiber size 1.558E-8 2.475E-6 2.151E-5 5.198E-5 14 96
22 MP:0009414 skeletal muscle fiber necrosis 2.266E-8 3.437E-6 2.986E-5 7.560E-5 8 24
23 MP:0005140 decreased cardiac muscle contractility 2.973E-8 4.313E-6 3.748E-5 9.919E-5 21 234
24 MP:0002972 abnormal cardiac muscle contractility 4.337E-8 5.975E-6 5.192E-5 1.447E-4 23 284
25 MP:0000278 abnormal myocardial fiber morphology 4.478E-8 5.975E-6 5.192E-5 1.494E-4 20 218
26 MP:0010240 decreased skeletal muscle size 5.079E-8 6.517E-6 5.663E-5 1.694E-4 12 74
27 MP:0009417 skeletal muscle atrophy 1.052E-7 1.299E-5 1.129E-4 3.508E-4 10 51
28 MP:0009413 skeletal muscle fiber atrophy 1.613E-7 1.856E-5 1.613E-4 5.382E-4 8 30
29 MP:0009406 decreased skeletal muscle fiber number 1.613E-7 1.856E-5 1.613E-4 5.382E-4 8 30
30 MP:0003358 abnormal hypaxial muscle morphology 1.772E-7 1.966E-5 1.708E-4 5.912E-4 16 153
31 MP:0004937 dilated heart 1.827E-7 1.966E-5 1.708E-4 6.095E-4 21 260
32 MP:0008772 increased heart ventricle size 2.923E-7 3.047E-5 2.648E-4 9.751E-4 18 200
33 MP:0001625 cardiac hypertrophy 3.150E-7 3.111E-5 2.703E-4 1.051E-3 18 201
34 MP:0005330 cardiomyopathy 3.170E-7 3.111E-5 2.703E-4 1.058E-3 15 140
35 MP:0002795 dilated cardiomyopathy 3.647E-7 3.476E-5 3.021E-4 1.217E-3 12 88
36 MP:0005598 decreased ventricle muscle contractility 6.422E-7 5.951E-5 5.171E-4 2.142E-3 13 110
37 MP:0003081 abnormal soleus morphology 6.862E-7 6.187E-5 5.376E-4 2.289E-3 7 25
38 MP:0000749 muscle degeneration 8.393E-7 7.368E-5 6.403E-4 2.800E-3 10 63
39 MP:0010552 abnormal HV interval 1.042E-6 8.912E-5 7.745E-4 3.476E-3 4 5
40 MP:0004090 abnormal sarcomere morphology 1.194E-6 9.959E-5 8.655E-4 3.984E-3 9 51
41 MP:0008022 dilated heart ventricle 1.288E-6 1.048E-4 9.105E-4 4.296E-3 15 156
42 MP:0000160 kyphosis 1.883E-6 1.496E-4 1.300E-3 6.281E-3 18 227
43 MP:0005608 cardiac interstitial fibrosis 1.995E-6 1.548E-4 1.345E-3 6.655E-3 10 69
44 MP:0004174 abnormal spine curvature 4.201E-6 3.091E-4 2.686E-3 1.401E-2 21 315
45 MP:0010090 increased circulating creatine kinase level 4.225E-6 3.091E-4 2.686E-3 1.410E-2 7 32
46 MP:0002279 abnormal diaphragm morphology 4.263E-6 3.091E-4 2.686E-3 1.422E-2 11 92
47 MP:0010579 increased heart left ventricle size 4.981E-6 3.536E-4 3.072E-3 1.662E-2 12 112
48 MP:0020280 increased creatine kinase level 5.265E-6 3.659E-4 3.180E-3 1.757E-2 7 33
49 MP:0002753 dilated heart left ventricle 5.469E-6 3.723E-4 3.235E-3 1.824E-2 12 113
50 MP:0010089 abnormal circulating creatine kinase level 6.510E-6 4.343E-4 3.774E-3 2.172E-2 7 34
Show 45 more annotations

6: Domain [Display Chart] 1560 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR013098 Ig I-set InterPro 1.730E-7 1.349E-4 1.070E-3 2.698E-4 15 190
2 PF07679 I-set Pfam 1.730E-7 1.349E-4 1.070E-3 2.698E-4 15 190
3 SM00033 CH SMART 4.882E-7 1.492E-4 1.183E-3 7.616E-4 9 65
4 PF00412 LIM Pfam 8.217E-7 1.492E-4 1.183E-3 1.282E-3 9 69
5 2.10.110.10 - Gene3D 9.307E-7 1.492E-4 1.183E-3 1.452E-3 9 70
6 PF00307 CH Pfam 9.307E-7 1.492E-4 1.183E-3 1.452E-3 9 70
7 1.10.418.10 - Gene3D 1.052E-6 1.492E-4 1.183E-3 1.641E-3 9 71
8 PS50023 LIM DOMAIN 2 PROSITE 1.052E-6 1.492E-4 1.183E-3 1.641E-3 9 71
9 IPR001781 Znf LIM InterPro 1.052E-6 1.492E-4 1.183E-3 1.641E-3 9 71
10 PS00478 LIM DOMAIN 1 PROSITE 1.052E-6 1.492E-4 1.183E-3 1.641E-3 9 71
11 SM00132 LIM SMART 1.052E-6 1.492E-4 1.183E-3 1.641E-3 9 71
12 PS50021 CH PROSITE 1.336E-6 1.737E-4 1.378E-3 2.085E-3 9 73
13 IPR001715 CH-domain InterPro 1.684E-6 2.021E-4 1.603E-3 2.628E-3 9 75
14 IPR018361 Caveolin CS InterPro 3.268E-6 2.683E-4 2.128E-3 5.098E-3 3 3
15 SM00735 ZM SMART 3.268E-6 2.683E-4 2.128E-3 5.098E-3 3 3
16 PS01210 CAVEOLIN PROSITE 3.268E-6 2.683E-4 2.128E-3 5.098E-3 3 3
17 PF01146 Caveolin Pfam 3.268E-6 2.683E-4 2.128E-3 5.098E-3 3 3
18 IPR006643 Zasp-like motif InterPro 3.268E-6 2.683E-4 2.128E-3 5.098E-3 3 3
19 IPR001612 Caveolin InterPro 3.268E-6 2.683E-4 2.128E-3 5.098E-3 3 3
20 PF01586 Basic Pfam 1.293E-5 9.166E-4 7.269E-3 2.016E-2 3 4
21 SM00520 BASIC SMART 1.293E-5 9.166E-4 7.269E-3 2.016E-2 3 4
22 IPR002546 Basic InterPro 1.293E-5 9.166E-4 7.269E-3 2.016E-2 3 4
23 SM00408 IGc2 SMART 5.412E-5 3.518E-3 2.790E-2
8.443E-2
13 235
24 IPR003598 Ig sub2 InterPro 5.412E-5 3.518E-3 2.790E-2
8.443E-2
13 235
25 IPR031847 DUF4749 InterPro 6.321E-5 3.522E-3 2.793E-2
9.861E-2
3 6
26 PF15936 DUF4749 Pfam 6.321E-5 3.522E-3 2.793E-2
9.861E-2
3 6
27 IPR001978 Troponin InterPro 6.321E-5 3.522E-3 2.793E-2
9.861E-2
3 6
28 PF00992 Troponin Pfam 6.321E-5 3.522E-3 2.793E-2
9.861E-2
3 6
29 4.10.270.10 - Gene3D 1.564E-4 8.133E-3
6.449E-2
2.440E-1
4 19
30 IPR027401 Myosin-like IQ dom InterPro 1.564E-4 8.133E-3
6.449E-2
2.440E-1
4 19
31 PF02029 Caldesmon Pfam 2.210E-4 1.077E-2
8.543E-2
3.447E-1
2 2
32 IPR006018 Caldesmon LSP InterPro 2.210E-4 1.077E-2
8.543E-2
3.447E-1
2 2
33 IPR001436 Alpha-crystallin/HSP InterPro 2.568E-4 1.178E-2
9.344E-2
4.006E-1
3 9
34 IPR031107 HSP20 InterPro 2.568E-4 1.178E-2
9.344E-2
4.006E-1
3 9
35 PF00595 PDZ Pfam 2.672E-4 1.191E-2
9.445E-2
4.169E-1
9 141
36 PS00020 ACTININ 2 PROSITE 3.409E-4 1.400E-2
1.110E-1
5.319E-1
4 23
37 PS00019 ACTININ 1 PROSITE 3.409E-4 1.400E-2
1.110E-1
5.319E-1
4 23
38 IPR001589 Actinin actin-bd CS InterPro 3.409E-4 1.400E-2
1.110E-1
5.319E-1
4 23
39 SM00228 PDZ SMART 3.824E-4 1.523E-2
1.208E-1
5.966E-1
9 148
40 IPR011992 EF-hand-dom pair InterPro 3.906E-4 1.523E-2
1.208E-1
6.094E-1
13 287
41 2.30.42.10 - Gene3D 4.220E-4 1.606E-2
1.273E-1
6.583E-1
9 150
42 PS50106 PDZ PROSITE 4.430E-4 1.638E-2
1.299E-1
6.911E-1
9 151
43 IPR001478 PDZ InterPro 4.649E-4 1.638E-2
1.299E-1
7.252E-1
9 152
44 IPR002068 A-crystallin/Hsp20 dom InterPro 4.934E-4 1.638E-2
1.299E-1
7.697E-1
3 11
45 PS01031 HSP20 PROSITE 4.934E-4 1.638E-2
1.299E-1
7.697E-1
3 11
46 IPR003096 SM22 calponin InterPro 4.934E-4 1.638E-2
1.299E-1
7.697E-1
3 11
47 PF00011 HSP20 Pfam 4.934E-4 1.638E-2
1.299E-1
7.697E-1
3 11
48 1.10.238.10 - Gene3D 5.695E-4 1.851E-2
1.468E-1
8.885E-1
12 261
49 SM00736 CADG SMART 6.564E-4 2.008E-2
1.592E-1
1.000E0
2 3
50 IPR027707 TNNT InterPro 6.564E-4 2.008E-2
1.592E-1
1.000E0
2 3
Show 45 more annotations

7: Pathway [Display Chart] 980 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 198903 Striated Muscle Contraction BioSystems: WikiPathways 6.664E-18 6.531E-15 4.875E-14 6.531E-15 15 38
2 106261 Muscle contraction BioSystems: REACTOME 3.825E-17 1.874E-14 1.399E-13 3.748E-14 16 51
3 106262 Striated Muscle Contraction BioSystems: REACTOME 4.389E-16 1.434E-13 1.070E-12 4.301E-13 13 31
4 114229 Hypertrophic cardiomyopathy (HCM) BioSystems: KEGG 2.818E-12 6.904E-10 5.154E-9 2.761E-9 15 83
5 121494 Dilated cardiomyopathy BioSystems: KEGG 9.631E-12 1.888E-9 1.409E-8 9.438E-9 15 90
6 576262 Extracellular matrix organization BioSystems: REACTOME 3.910E-8 6.387E-6 4.768E-5 3.832E-5 19 264
7 672454 Arrhythmogenic right ventricular cardiomyopathy BioSystems: WikiPathways 2.435E-7 2.983E-5 2.227E-4 2.386E-4 10 74
8 117293 Arrhythmogenic right ventricular cardiomyopathy (ARVC) BioSystems: KEGG 2.435E-7 2.983E-5 2.227E-4 2.386E-4 10 74
9 106110 Integrin cell surface interactions BioSystems: REACTOME 9.164E-7 9.614E-5 7.177E-4 8.980E-4 9 66
10 83067 Focal adhesion BioSystems: KEGG 9.810E-7 9.614E-5 7.177E-4 9.614E-4 15 206
11 125138 Viral myocarditis BioSystems: KEGG 5.762E-6 5.133E-4 3.832E-3 5.647E-3 8 62
12 P00016 Cytoskeletal regulation by Rho GTPase PantherDB 1.296E-5 1.058E-3 7.902E-3 1.270E-2 8 69
13 SMP00375 Verapamil Pathway SMPDB 3.130E-5 2.191E-3 1.636E-2 3.068E-2 7 57
14 SMP00359 Diltiazem Pathway SMPDB 3.130E-5 2.191E-3 1.636E-2 3.068E-2 7 57
15 198795 Focal Adhesion BioSystems: WikiPathways 3.729E-5 2.436E-3 1.819E-2 3.654E-2 12 184
16 833810 Non-integrin membrane-ECM interactions BioSystems: REACTOME 4.904E-5 3.003E-3 2.242E-2 4.805E-2 6 42
17 198812 Endochondral Ossification BioSystems: WikiPathways 8.175E-5 4.713E-3 3.518E-2
8.012E-2
7 66
18 P00044 Nicotinic acetylcholine receptor signaling pathway PantherDB 9.785E-5 5.327E-3 3.977E-2
9.589E-2
8 91
19 160997 Myogenesis BioSystems: REACTOME 1.180E-4 5.780E-3 4.315E-2
1.156E-1
5 31
20 160998 CDO in myogenesis BioSystems: REACTOME 1.180E-4 5.780E-3 4.315E-2
1.156E-1
5 31
21 83089 Regulation of actin cytoskeleton BioSystems: KEGG 1.663E-4 7.763E-3
5.795E-2
1.630E-1
12 215
22 712094 Cardiac Progenitor Differentiation BioSystems: WikiPathways 1.857E-4 8.270E-3
6.174E-2
1.819E-1
6 53
23 M6220 Agrin in Postsynaptic Differentiation MSigDB C2 BIOCARTA (v5.1) 2.454E-4 9.945E-3
7.424E-2
2.405E-1
5 36
24 198828 Hypertrophy Model BioSystems: WikiPathways 2.475E-4 9.945E-3
7.424E-2
2.425E-1
4 20
25 782000 Proteoglycans in cancer BioSystems: KEGG 2.537E-4 9.945E-3
7.424E-2
2.486E-1
12 225
26 83071 Tight junction BioSystems: KEGG 2.861E-4 1.053E-2
7.861E-2
2.804E-1
9 134
27 SMP00367 Carvedilol Pathway SMPDB 3.019E-4 1.053E-2
7.861E-2
2.959E-1
4 21
28 SMP00368 Labetalol Pathway SMPDB 3.019E-4 1.053E-2
7.861E-2
2.959E-1
4 21
29 119531 Role of Abl in Robo-Slit signaling BioSystems: REACTOME 3.116E-4 1.053E-2
7.861E-2
3.054E-1
3 9
30 M3270 Integrin Signaling Pathway MSigDB C2 BIOCARTA (v5.1) 3.224E-4 1.053E-2
7.861E-2
3.159E-1
7 82
31 106050 Platelet degranulation BioSystems: REACTOME 4.021E-4 1.271E-2
9.490E-2
3.941E-1
7 85
32 83068 ECM-receptor interaction BioSystems: KEGG 4.320E-4 1.323E-2
9.876E-2
4.233E-1
7 86
33 161025 Smooth Muscle Contraction BioSystems: REACTOME 5.164E-4 1.534E-2
1.145E-1
5.061E-1
4 24
34 106048 Response to elevated platelet cytosolic Ca2+ BioSystems: REACTOME 5.695E-4 1.641E-2
1.225E-1
5.581E-1
7 90
35 908257 Adrenergic signaling in cardiomyocytes BioSystems: KEGG 6.239E-4 1.747E-2
1.304E-1
6.115E-1
9 149
36 83055 p53 signaling pathway BioSystems: KEGG 7.269E-4 1.979E-2
1.477E-1
7.124E-1
6 68
37 M2701 Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. MSigDB C2 BIOCARTA (v5.1) 8.218E-4 2.177E-2
1.625E-1
8.053E-1
4 27
38 198816 Integrin-mediated cell adhesion BioSystems: WikiPathways 1.007E-3 2.596E-2
1.938E-1
9.866E-1
7 99
39 93344 Cardiac muscle contraction BioSystems: KEGG 1.497E-3 3.761E-2
2.808E-1
1.000E0
6 78
40 833812 ECM proteoglycans BioSystems: REACTOME 1.775E-3 4.092E-2
3.054E-1
1.000E0
5 55
41 M16884 Role of nicotinic acetylcholine receptors in the regulation of apoptosis MSigDB C2 BIOCARTA (v5.1) 1.913E-3 4.092E-2
3.054E-1
1.000E0
3 16
42 M16801 Genes related to regulation of the actin cytoskeleton MSigDB C2 BIOCARTA (v5.1) 2.220E-3 4.092E-2
3.054E-1
1.000E0
4 35
43 SMP00307 Propranolol Pathway SMPDB 2.296E-3 4.092E-2
3.054E-1
1.000E0
3 17
44 SMP00302 Metoprolol Pathway SMPDB 2.296E-3 4.092E-2
3.054E-1
1.000E0
3 17
45 SMP00299 Betaxolol Pathway SMPDB 2.296E-3 4.092E-2
3.054E-1
1.000E0
3 17
46 SMP00304 Oxprenolol Pathway SMPDB 2.296E-3 4.092E-2
3.054E-1
1.000E0
3 17
47 SMP00297 Alprenolol Pathway SMPDB 2.296E-3 4.092E-2
3.054E-1
1.000E0
3 17
48 SMP00301 Esmolol Pathway SMPDB 2.296E-3 4.092E-2
3.054E-1
1.000E0
3 17
49 SMP00303 Nadolol Pathway SMPDB 2.296E-3 4.092E-2
3.054E-1
1.000E0
3 17
50 SMP00305 Penbutolol Pathway SMPDB 2.296E-3 4.092E-2
3.054E-1
1.000E0
3 17
Show 45 more annotations

8: Pubmed [Display Chart] 32721 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20301486 Dilated Cardiomyopathy Overview Pubmed 6.494E-24 2.125E-19 2.332E-18 2.125E-19 14 32
2 21423176 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for Ã?-Pix in negative regulation of focal adhesion maturation. Pubmed 1.380E-17 2.258E-13 2.478E-12 4.517E-13 21 286
3 20301725 Hypertrophic Cardiomyopathy Overview Pubmed 1.768E-15 1.928E-11 2.116E-10 5.784E-11 9 22
4 20474083 A novel custom resequencing array for dilated cardiomyopathy. Pubmed 5.115E-14 2.883E-10 3.163E-9 1.674E-9 8 19
5 20474083:gr A novel custom resequencing array for dilated cardiomyopathy. GeneRIF 5.115E-14 2.883E-10 3.163E-9 1.674E-9 8 19
6 20936779 A human MAP kinase interactome. Pubmed 5.286E-14 2.883E-10 3.163E-9 1.730E-9 22 486
7 20031618 Prevalence of sarcomere protein gene mutations in preadolescent children with hypertrophic cardiomyopathy. Pubmed 1.132E-11 4.629E-8 5.079E-7 3.703E-7 6 11
8 20031618:gr Prevalence of sarcomere protein gene mutations in preadolescent children with hypertrophic cardiomyopathy. GeneRIF 1.132E-11 4.629E-8 5.079E-7 3.703E-7 6 11
9 23414517 A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. Pubmed 2.068E-11 7.518E-8 8.250E-7 6.767E-7 10 79
10 23788249 ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Pubmed 2.706E-11 8.855E-8 9.717E-7 8.855E-7 9 57
11 18513529 Relationship between sex, shape, and substrate in hypertrophic cardiomyopathy. Pubmed 4.165E-11 1.239E-7 1.359E-6 1.363E-6 6 13
12 18157088 Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2. Pubmed 8.762E-11 2.389E-7 2.622E-6 2.867E-6 8 43
13 11309420 Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies. Pubmed 1.152E-9 2.899E-6 3.181E-5 3.769E-5 5 10
14 20301582 Limb-Girdle Muscular Dystrophy Overview Pubmed 1.270E-9 2.967E-6 3.256E-5 4.154E-5 6 21
15 16385451 A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Pubmed 1.715E-9 3.629E-6 3.983E-5 5.612E-5 16 417
16 16385451:gr A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. GeneRIF 1.775E-9 3.629E-6 3.983E-5 5.807E-5 16 418
17 18513529:gr Relationship between sex, shape, and substrate in hypertrophic cardiomyopathy. GeneRIF 3.588E-9 6.906E-6 7.578E-5 1.174E-4 5 12
18 20334626:gr Myogenic regulatory factors regulate M-cadherin expression by targeting its proximal promoter elements. GeneRIF 4.325E-9 7.861E-6 8.626E-5 1.415E-4 4 5
19 20301299 Thoracic Aortic Aneurysms and Aortic Dissections Pubmed 5.804E-9 9.996E-6 1.097E-4 1.899E-4 5 13
20 19199708 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Pubmed 1.196E-8 1.626E-5 1.784E-4 3.913E-4 15 414
21 17987659 Nebulette interacts with filamin C. Pubmed 1.292E-8 1.626E-5 1.784E-4 4.227E-4 4 6
22 19412328:gr Coding sequence mutations identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 patients with familial or idiopathic dilated cardiomyopathy. GeneRIF 1.292E-8 1.626E-5 1.784E-4 4.227E-4 4 6
23 19412328 Coding sequence mutations identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 patients with familial or idiopathic dilated cardiomyopathy. Pubmed 1.292E-8 1.626E-5 1.784E-4 4.227E-4 4 6
24 20201937:gr Common susceptibility variants examined for association with dilated cardiomyopathy. GeneRIF 1.292E-8 1.626E-5 1.784E-4 4.227E-4 4 6
25 8987992 Interaction of deletion mutants of troponins I and T: COOH-terminal truncation of troponin T abolishes troponin I binding and reduces Ca2+ sensitivity of the reconstituted regulatory system. Pubmed 1.292E-8 1.626E-5 1.784E-4 4.227E-4 4 6
26 20201937 Common susceptibility variants examined for association with dilated cardiomyopathy. Pubmed 1.292E-8 1.626E-5 1.784E-4 4.227E-4 4 6
27 15703204 Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current. Pubmed 3.001E-8 3.507E-5 3.849E-4 9.820E-4 4 7
28 9418854 Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2. Pubmed 3.001E-8 3.507E-5 3.849E-4 9.820E-4 4 7
29 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 3.309E-8 3.609E-5 3.960E-4 1.083E-3 14 383
30 19453261:gr High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. GeneRIF 3.309E-8 3.609E-5 3.960E-4 1.083E-3 14 383
31 20628624 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". Pubmed 4.400E-8 4.499E-5 4.937E-4 1.440E-3 10 172
32 20628624:gr Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". GeneRIF 4.400E-8 4.499E-5 4.937E-4 1.440E-3 10 172
33 20301672 Myofibrillar Myopathy Pubmed 5.977E-8 5.588E-5 6.131E-4 1.956E-3 4 8
34 20359594 Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations. Pubmed 5.977E-8 5.588E-5 6.131E-4 1.956E-3 4 8
35 20359594:gr Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations. GeneRIF 5.977E-8 5.588E-5 6.131E-4 1.956E-3 4 8
36 19293840:gr The role of sarcomere gene mutations in patients with idiopathic dilated cardiomyopathy. GeneRIF 1.071E-7 9.224E-5 1.012E-3 3.505E-3 4 9
37 16754800 Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study. Pubmed 1.071E-7 9.224E-5 1.012E-3 3.505E-3 4 9
38 19293840 The role of sarcomere gene mutations in patients with idiopathic dilated cardiomyopathy. Pubmed 1.071E-7 9.224E-5 1.012E-3 3.505E-3 4 9
39 16526095 Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression. Pubmed 1.141E-7 9.571E-5 1.050E-3 3.733E-3 5 22
40 22236542 Expression of caveolin-1, caveolin-2 and caveolin-3 in thyroid cancer and stroma. Pubmed 1.609E-7 9.931E-5 1.090E-3 5.263E-3 3 3
41 22236542:gr Expression of caveolin-1, caveolin-2 and caveolin-3 in thyroid cancer and stroma. GeneRIF 1.609E-7 9.931E-5 1.090E-3 5.263E-3 3 3
42 12473556 Prevalence and severity of "benign" mutations in the beta-myosin heavy chain, cardiac troponin T, and alpha-tropomyosin genes in hypertrophic cardiomyopathy. Pubmed 1.609E-7 9.931E-5 1.090E-3 5.263E-3 3 3
43 25863306 Dextrocardia and symmetric hypertrophic cardiomyopathy with multiple mutations of genes encoding the sarcomere proteins. Pubmed 1.609E-7 9.931E-5 1.090E-3 5.263E-3 3 3
44 18096699:gr Caveolin regulates endocytosis of the muscle repair protein, dysferlin. GeneRIF 1.609E-7 9.931E-5 1.090E-3 5.263E-3 3 3
45 12648214 Caveolin expression and localization in human keratinocytes suggest a role in lamellar granule biogenesis. Pubmed 1.609E-7 9.931E-5 1.090E-3 5.263E-3 3 3
46 18506004:gr Mutations in sarcomere protein genes in left ventricular noncompaction. GeneRIF 1.609E-7 9.931E-5 1.090E-3 5.263E-3 3 3
47 12473556:gr Prevalence and severity of "benign" mutations in the beta-myosin heavy chain, cardiac troponin T, and alpha-tropomyosin genes in hypertrophic cardiomyopathy. GeneRIF 1.609E-7 9.931E-5 1.090E-3 5.263E-3 3 3
48 17615539:gr Different caveolin isoforms in the retina of melanoma malignum affected human eye. GeneRIF 1.609E-7 9.931E-5 1.090E-3 5.263E-3 3 3
49 18506004 Mutations in sarcomere protein genes in left ventricular noncompaction. Pubmed 1.609E-7 9.931E-5 1.090E-3 5.263E-3 3 3
50 17615539 Different caveolin isoforms in the retina of melanoma malignum affected human eye. Pubmed 1.609E-7 9.931E-5 1.090E-3 5.263E-3 3 3
Show 45 more annotations

9: Interaction [Display Chart] 4101 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:TNNI1 TNNI1 interactions 1.418E-12 5.814E-9 5.172E-8 5.814E-9 9 17
2 int:TRIM63 TRIM63 interactions 5.734E-11 1.176E-7 1.046E-6 2.352E-7 15 99
3 int:ACTA1 ACTA1 interactions 4.039E-10 5.521E-7 4.912E-6 1.656E-6 19 195
4 int:DMD DMD interactions 8.211E-10 8.419E-7 7.490E-6 3.367E-6 11 54
5 int:ACTN2 ACTN2 interactions 5.585E-9 4.581E-6 4.076E-5 2.291E-5 12 80
6 int:CAV3 CAV3 interactions 1.784E-7 1.219E-4 1.084E-3 7.314E-4 7 27
7 int:TNNT2 TNNT2 interactions 4.514E-7 2.645E-4 2.353E-3 1.851E-3 5 11
8 int:SGCD SGCD interactions 7.637E-7 3.915E-4 3.483E-3 3.132E-3 5 12
9 int:MYH9 MYH9 interactions 1.115E-6 5.081E-4 4.520E-3 4.573E-3 19 319
10 int:DAG1 DAG1 interactions 1.694E-6 6.949E-4 6.182E-3 6.949E-3 8 52
11 int:NEB NEB interactions 2.294E-6 8.553E-4 7.609E-3 9.409E-3 6 25
12 int:TPM1 TPM1 interactions 2.559E-6 8.747E-4 7.781E-3 1.050E-2 11 115
13 int:ANKRD1 ANKRD1 interactions 4.423E-6 1.395E-3 1.241E-2 1.814E-2 4 8
14 int:ACTN1 ACTN1 interactions 5.879E-6 1.722E-3 1.532E-2 2.411E-2 12 150
15 int:SGCA SGCA interactions 7.630E-6 1.936E-3 1.723E-2 3.129E-2 5 18
16 int:FBXO32 FBXO32 interactions 7.707E-6 1.936E-3 1.723E-2 3.161E-2 12 154
17 int:CALM1 CALM1 interactions 8.026E-6 1.936E-3 1.723E-2 3.292E-2 17 300
18 int:ACTC1 ACTC1 interactions 1.192E-5 2.526E-3 2.247E-2 4.887E-2 8 67
19 int:SGCB SGCB interactions 1.294E-5 2.526E-3 2.247E-2
5.305E-2
4 10
20 int:RAPSN RAPSN interactions 1.294E-5 2.526E-3 2.247E-2
5.305E-2
4 10
21 int:CAPN3 CAPN3 interactions 1.294E-5 2.526E-3 2.247E-2
5.305E-2
4 10
22 int:MYO19 MYO19 interactions 2.222E-5 4.143E-3 3.685E-2
9.114E-2
12 171
23 int:CRYAB CRYAB interactions 3.447E-5 6.147E-3
5.468E-2
1.414E-1
9 100
24 int:TNNC1 TNNC1 interactions 4.239E-5 7.243E-3
6.443E-2
1.738E-1
4 13
25 int:MYH3 MYH3 interactions 5.859E-5 9.611E-3
8.550E-2
2.403E-1
4 14
26 int:FBN2 FBN2 interactions 7.888E-5 1.198E-2
1.066E-1
3.235E-1
4 15
27 int:FBN1 FBN1 interactions 7.888E-5 1.198E-2
1.066E-1
3.235E-1
4 15
28 int:MYPN MYPN interactions 1.038E-4 1.521E-2
1.353E-1
4.259E-1
4 16
29 int:FLNA FLNA interactions 1.139E-4 1.610E-2
1.433E-1
4.670E-1
15 300
30 int:MYH4 MYH4 interactions 1.341E-4 1.726E-2
1.536E-1
5.499E-1
4 17
31 int:XIRP2 XIRP2 interactions 1.389E-4 1.726E-2
1.536E-1
5.697E-1
3 7
32 int:ABRA ABRA interactions 1.389E-4 1.726E-2
1.536E-1
5.697E-1
3 7
33 int:SGCG SGCG interactions 1.389E-4 1.726E-2
1.536E-1
5.697E-1
3 7
34 int:MYOZ1 MYOZ1 interactions 1.702E-4 1.969E-2
1.752E-1
6.980E-1
4 18
35 int:LDB3 LDB3 interactions 1.702E-4 1.969E-2
1.752E-1
6.980E-1
4 18
36 int:ACTN4 ACTN4 interactions 1.729E-4 1.969E-2
1.752E-1
7.089E-1
9 123
37 int:HSPB2 HSPB2 interactions 2.006E-4 2.113E-2
1.879E-1
8.226E-1
8 99
38 int:MYH6 MYH6 interactions 2.006E-4 2.113E-2
1.879E-1
8.227E-1
5 34
39 int:TNNI3 TNNI3 interactions 2.129E-4 2.113E-2
1.879E-1
8.730E-1
4 19
40 int:SYNPO2 SYNPO2 interactions 2.129E-4 2.113E-2
1.879E-1
8.730E-1
4 19
41 int:TMEM260 TMEM260 interactions 2.196E-4 2.113E-2
1.879E-1
9.006E-1
3 8
42 int:XIRP1 XIRP1 interactions 2.196E-4 2.113E-2
1.879E-1
9.006E-1
3 8
43 int:CAPZA2 CAPZA2 interactions 2.215E-4 2.113E-2
1.879E-1
9.084E-1
13 250
44 int:SCN5A SCN5A interactions 3.204E-4 2.781E-2
2.474E-1
1.000E0
4 21
45 int:MYOZ3 MYOZ3 interactions 3.255E-4 2.781E-2
2.474E-1
1.000E0
3 9
46 int:GLIPR2 GLIPR2 interactions 3.255E-4 2.781E-2
2.474E-1
1.000E0
3 9
47 int:NGF NGF interactions 3.255E-4 2.781E-2
2.474E-1
1.000E0
3 9
48 int:MYH8 MYH8 interactions 3.255E-4 2.781E-2
2.474E-1
1.000E0
3 9
49 int:TPM2 TPM2 interactions 3.325E-4 2.783E-2
2.476E-1
1.000E0
7 81
50 int:MYH2 MYH2 interactions 3.867E-4 3.117E-2
2.773E-1
1.000E0
4 22
Show 45 more annotations

10: Cytoband [Display Chart] 232 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1q21 1q21 1.137E-4 2.637E-2
1.589E-1
2.637E-2 6 93

11: Transcription Factor Binding Site [Display Chart] 532 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CTAWWWATA V$RSRFC4 Q2 CTAWWWATA V$RSRFC4 Q2 7.214E-9 3.838E-6 2.631E-5 3.838E-6 23 298
2 V$TEF1 Q6 V$TEF1 Q6 2.390E-7 5.420E-5 3.715E-4 1.271E-4 16 180
3 V$HMEF2 Q6 V$HMEF2 Q6 3.480E-7 5.420E-5 3.715E-4 1.851E-4 13 120
4 V$SRF Q6 V$SRF Q6 4.075E-7 5.420E-5 3.715E-4 2.168E-4 17 211
5 V$E2A Q2 V$E2A Q2 6.185E-7 6.581E-5 4.511E-4 3.291E-4 16 193
6 V$MYOD Q6 V$MYOD Q6 9.983E-7 8.852E-5 6.068E-4 5.311E-4 16 200
7 V$RSRFC4 01 V$RSRFC4 01 1.681E-6 1.278E-4 8.759E-4 8.944E-4 16 208
8 WGGAATGY V$TEF1 Q6 WGGAATGY V$TEF1 Q6 3.109E-6 2.067E-4 1.417E-3 1.654E-3 19 299
9 V$MYOGENIN Q6 V$MYOGENIN Q6 4.344E-6 2.459E-4 1.686E-3 2.311E-3 15 198
10 V$E47 02 V$E47 02 4.622E-6 2.459E-4 1.686E-3 2.459E-3 15 199
11 YKACATTT UNKNOWN YKACATTT UNKNOWN 5.251E-6 2.540E-4 1.741E-3 2.794E-3 16 227
12 V$E47 01 V$E47 01 6.265E-6 2.778E-4 1.904E-3 3.333E-3 15 204
13 V$SRF C V$SRF C 7.211E-6 2.844E-4 1.950E-3 3.836E-3 14 181
14 V$TAL1BETAITF2 01 V$TAL1BETAITF2 01 7.484E-6 2.844E-4 1.950E-3 3.982E-3 15 207
15 V$AMEF2 Q6 V$AMEF2 Q6 9.437E-6 3.347E-4 2.294E-3 5.021E-3 15 211
16 V$MEF2 03 V$MEF2 03 2.009E-5 6.680E-4 4.579E-3 1.069E-2 14 198
17 V$MEF2 01 V$MEF2 01 2.141E-5 6.702E-4 4.594E-3 1.139E-2 11 125
18 V$TAL1ALPHAE47 01 V$TAL1ALPHAE47 01 3.301E-5 9.119E-4 6.251E-3 1.756E-2 14 207
19 CATTGTYY V$SOX9 B1 CATTGTYY V$SOX9 B1 3.423E-5 9.119E-4 6.251E-3 1.821E-2 17 293
20 V$AP4 Q6 01 V$AP4 Q6 01 3.481E-5 9.119E-4 6.251E-3 1.852E-2 14 208
21 V$RSRFC4 Q2 V$RSRFC4 Q2 3.599E-5 9.119E-4 6.251E-3 1.915E-2 13 182
22 V$SRF Q4 V$SRF Q4 6.275E-5 1.517E-3 1.040E-2 3.338E-2 13 192
23 CCAWWNAAGG V$SRF Q4 CCAWWNAAGG V$SRF Q4 6.822E-5 1.578E-3 1.082E-2 3.629E-2 8 74
24 V$MEF2 02 V$MEF2 02 8.168E-5 1.811E-3 1.241E-2 4.345E-2 13 197
25 V$AP4 Q6 V$AP4 Q6 1.130E-4 2.404E-3 1.648E-2
6.010E-2
12 176
26 V$NKX25 01 V$NKX25 01 1.387E-4 2.839E-3 1.946E-2
7.381E-2
9 104
27 AAAYWAACM V$HFH4 01 AAAYWAACM V$HFH4 01 1.484E-4 2.924E-3 2.004E-2
7.894E-2
13 209
28 V$HEB Q6 V$HEB Q6 2.154E-4 4.092E-3 2.805E-2
1.146E-1
13 217
29 V$EVI1 04 V$EVI1 04 2.814E-4 5.162E-3 3.538E-2
1.497E-1
12 194
30 V$LBP1 Q6 V$LBP1 Q6 3.801E-4 6.741E-3 4.621E-2
2.022E-1
11 172
31 V$RORA2 01 V$RORA2 01 4.617E-4 7.731E-3
5.300E-2
2.456E-1
9 122
32 V$FOXO4 02 V$FOXO4 02 4.650E-4 7.731E-3
5.300E-2
2.474E-1
12 205
33 V$MEF2 Q6 01 V$MEF2 Q6 01 5.299E-4 8.542E-3
5.856E-2
2.819E-1
12 208
34 V$AP1 Q6 01 V$AP1 Q6 01 6.548E-4 9.966E-3
6.832E-2
3.484E-1
12 213
35 RTTTNNNYTGGM UNKNOWN RTTTNNNYTGGM UNKNOWN 6.557E-4 9.966E-3
6.832E-2
3.488E-1
9 128
36 V$HOXA4 Q2 V$HOXA4 Q2 7.411E-4 1.095E-2
7.507E-2
3.942E-1
12 216
37 V$TATA C V$TATA C 7.734E-4 1.112E-2
7.623E-2
4.115E-1
13 248
38 TAAWWATAG V$RSRFC4 Q2 TAAWWATAG V$RSRFC4 Q2 8.642E-4 1.210E-2
8.293E-2
4.597E-1
9 133
39 V$AREB6 03 V$AREB6 03 9.555E-4 1.303E-2
8.933E-2
5.083E-1
11 192
40 V$NF1 Q6 V$NF1 Q6 9.798E-4 1.303E-2
8.933E-2
5.213E-1
12 223
41 V$PAX4 02 V$PAX4 02 1.332E-3 1.728E-2
1.184E-1
7.084E-1
11 200
42 V$TBP 01 V$TBP 01 1.561E-3 1.977E-2
1.355E-1
8.304E-1
11 204
43 V$HEN1 02 V$HEN1 02 1.919E-3 2.374E-2
1.627E-1
1.000E0
9 149
44 V$AP4 Q5 V$AP4 Q5 2.540E-3 3.060E-2
2.097E-1
1.000E0
11 217
45 V$CEBP Q2 V$CEBP Q2 2.588E-3 3.060E-2
2.097E-1
1.000E0
10 186
46 YNGTTNNNATT UNKNOWN YNGTTNNNATT UNKNOWN 2.781E-3 3.166E-2
2.170E-1
1.000E0
13 286
47 V$IRF Q6 V$IRF Q6 2.797E-3 3.166E-2
2.170E-1
1.000E0
10 188
48 V$SRY 01 V$SRY 01 2.859E-3 3.169E-2
2.172E-1
1.000E0
9 158
49 V$HFH3 01 V$HFH3 01 3.521E-3 3.822E-2
2.620E-1
1.000E0
9 163
50 V$FOXD3 01 V$FOXD3 01 3.666E-3 3.901E-2
2.674E-1
1.000E0
9 164
Show 45 more annotations

12: Gene Family [Display Chart] 131 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 593 CD molecules|V-set domain containing|I-set domain containing|Sialic acid binding Ig like lectins genenames.org 9.158E-10 1.200E-7 6.546E-7 1.200E-7 14 161
2 1218 LIM domain containing genenames.org 7.052E-9 4.619E-7 2.520E-6 9.239E-7 9 59
3 1219 EF-hand domain containing|Troponin complex subunits genenames.org 6.719E-7 2.934E-5 1.601E-4 8.801E-5 4 8
4 1220 PDZ domain containing genenames.org 2.362E-5 7.737E-4 4.221E-3 3.095E-3 9 152
5 585 Small heat shock proteins genenames.org 1.556E-4 4.078E-3 2.225E-2 2.039E-2 3 11
6 657 Myosin light chains|EF-hand domain containing genenames.org 3.358E-4 7.332E-3 4.000E-2 4.399E-2 3 14
7 1098 Myosin heavy chains genenames.org 4.167E-4 7.797E-3 4.254E-2
5.458E-2
3 15
8 1326 Cavins genenames.org 5.957E-4 9.755E-3
5.323E-2
7.804E-2
2 4
9 1160 CD molecules|Integrin alpha subunits genenames.org 7.308E-4 1.064E-2
5.804E-2
9.574E-2
3 18
10 420 Basic helix-loop-helix proteins genenames.org 8.604E-4 1.127E-2
6.150E-2
1.127E-1
6 110
11 1021 Ankyrin repeat domain containing|Death associated protein kinases genenames.org 9.863E-4 1.175E-2
6.409E-2
1.292E-1
2 5
12 459 S100 calcium binding proteins|EF-hand domain containing genenames.org 1.165E-3 1.272E-2
6.939E-2
1.526E-1
3 21
13 929 Actins genenames.org 1.470E-3 1.481E-2
8.081E-2
1.925E-1
2 6
14 863 EF-hand domain containing genenames.org 1.714E-3 1.604E-2
8.752E-2
2.246E-1
8 219
15 473 Cyclins|Mediator complex genenames.org 3.017E-3 2.635E-2
1.438E-1
3.953E-1
3 29
16 682 Pleckstrin homology domain containing genenames.org 4.900E-3 4.012E-2
2.189E-1
6.420E-1
7 206
17 555 Fibronectin type III domain containing|Immunoglobulin like domain containing genenames.org 5.646E-3 4.350E-2
2.374E-1
7.396E-1
6 160
Show 12 more annotations

13: Coexpression [Display Chart] 7002 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5909 Genes involved in development of skeletal muscle (myogenesis). MSigDB H: Hallmark Gene Sets (v5.1) 2.342E-37 1.640E-33 1.547E-32 1.640E-33 41 200
2 M9065 Genes up-regulated in C2AS12 cells (myoblast) by IGF1 [GeneID=3479] vs PDGFB [GeneID=5155]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.020E-29 7.072E-26 6.670E-25 1.414E-25 26 82
3 M768 Genes commonly up-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.228E-28 2.867E-25 2.704E-24 8.600E-25 27 98
4 M1557 Genes up-regulated in NIH 3T3 cells (fibroblasts) 24 h after inducing MyoD [GeneID=4654] differentiation program. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.545E-25 4.454E-22 4.201E-21 1.782E-21 24 89
5 M16123 Muscle development genes up-regulated in Rh4 cells (alveolar rhabdomyosarcoma, ARMS) but not in the RD cells (embryonal rhabdomyosarcoma, ERMS) after knockdown of PAX3-FOXO1 [GeneID=5077;2308] fusion by RNAi for 72 hr. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.448E-23 2.028E-20 1.913E-19 1.014E-19 19 50
6 M78 Genes up-regulated in Rh4 cells (alveolar rhabdomyosarcoma, ARMS) after knockdown of the PAX3-FOXO1 [GeneiD=5077;2308] fusion protein by RNAi for 72 hr. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.214E-23 8.419E-20 7.940E-19 5.051E-19 30 207
7 M2573 Genes consistently up-regulated in mammary stem cells both in mouse and human species. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.449E-20 7.452E-17 7.028E-16 5.216E-16 39 489
8 M2043 Cluster f: genes identifying an intrinsic group in head and neck squamous cell carcinoma (HNSCC). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.430E-19 1.251E-16 1.180E-15 1.001E-15 17 54
9 M12004 Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of both HDAC1 and HDAC2 [GeneID=3065;3066] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.858E-19 2.223E-16 2.097E-15 2.001E-15 28 231
10 M19391 Genes down-regulated in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.212E-18 1.549E-15 1.461E-14 1.549E-14 37 480
11 M2293 Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.373E-17 8.741E-15 8.244E-14 9.615E-14 30 315
12 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.957E-17 1.725E-14 1.627E-13 2.070E-13 35 460
13 M3001 Genes up-regulated in type 1 (soleus) vs type 2B (EDL) myofibers. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.371E-16 1.277E-13 1.205E-12 1.660E-12 13 35
14 M6906 Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC2 [GeneID=3066] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.636E-15 3.819E-12 3.602E-11 5.347E-11 19 132
15 GSE32533 WT VS MIR17 OVEREXPRESS ACT CD4 TCELL DN Genes down-regulated in activated CD4 [GeneID=920] T cells: wildtype versus over-expressing MIR17 [GeneID=406952]. MSigDB C7: Immunologic Signatures (v5.1) 1.714E-14 7.502E-12 7.075E-11 1.200E-10 22 200
16 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v5.1) 1.714E-14 7.502E-12 7.075E-11 1.200E-10 22 200
17 M4995 Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.306E-14 1.362E-11 1.284E-10 2.315E-10 29 390
18 M2584 Genes up-regulated in the ventricles of healthy hearts, compared to atria. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.956E-14 2.317E-11 2.185E-10 4.170E-10 24 261
19 M15981 Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.937E-13 1.451E-10 1.368E-9 2.757E-9 29 430
20 M7396 Genes down-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.260E-13 1.842E-10 1.737E-9 3.683E-9 29 435
21 M4001 Genes down-regulated in RD cells (embryonal rhabdomyosarcoma, ERMS) by expression of PAX3- or PAX7-FOXO1 [GeneID=5077;5081;2308] fusions off retroviral vectors. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.449E-12 1.150E-9 1.084E-8 2.415E-8 13 68
22 M1466 Genes up-regulated in MEF cells (embryonic fibroblast) expressing ~25% of YY1 [GeneID=7528]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.867E-12 1.867E-9 1.761E-8 4.108E-8 20 214
23 M4913 Genes down-regulated in adipose tissue mesenchymal stem cells (ASC) vs bone marrow mesenchymal stem cells (rBMSC) MSigDB C2: CGP Curated Gene Sets (v5.1) 9.366E-12 2.851E-9 2.689E-8 6.558E-8 15 108
24 M4680 Genes up-regulated in RD cells (embryonal rhabdomyosarcoma, ERMS) by expression of PAX3- or PAX7-FOXO1 [GeneID=5077;5081;2308] fusions off retroviral vectors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.930E-11 5.631E-9 5.311E-8 1.352E-7 21 255
25 M12225 Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.329E-11 6.524E-9 6.153E-8 1.631E-7 19 205
26 M17471 Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS, non-invasive). MSigDB C2: CGP Curated Gene Sets (v5.1) 3.456E-11 9.308E-9 8.779E-8 2.420E-7 24 351
27 M10381 Genes down-regulated in transformed NIH3T3 cells (fibroblasts transformed by activated KRAS [GeneID=3845]) vs normal cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.850E-11 1.258E-8 1.186E-7 3.396E-7 16 142
28 M2448 Genes upregulated in KRAS [GeneID=3845] knockdown vs control in a human cell line. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.725E-11 1.432E-8 1.350E-7 4.009E-7 13 84
29 M12890 Genes up-regulated in HT1080 cells (fibrosarcoma) over-expressing MMP14 [GeneID=4323] compared to those with knockdown of the gene by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.001E-10 7.246E-8 6.834E-7 2.101E-6 20 266
30 M2571 Genes down-regulated during prostate cancer progression in the JOCK1 model due to inducible activation of FGFR1 [GeneID=2260] gene in prostate. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.418E-10 1.456E-7 1.373E-6 4.494E-6 21 308
31 M10605 Genes down-regulated in medullary breast cancer (MBC) relative to ductal breast cancer (DBD). MSigDB C2: CGP Curated Gene Sets (v5.1) 6.654E-10 1.456E-7 1.373E-6 4.659E-6 16 169
32 M1124 Pubertal genes up-regulated by TGFB1 [GeneID=7040]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.654E-10 1.456E-7 1.373E-6 4.659E-6 16 169
33 M1804 Genes up-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.397E-10 1.569E-7 1.480E-6 5.179E-6 20 280
34 M14134 Genes down-regulated in ductal carcinoma vs normal ductal breast cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.834E-10 1.819E-7 1.716E-6 6.186E-6 17 198
35 M5463 Genes up-regulated in comparison of dendritic cells (DC) versus B cells. MSigDB C7: Immunologic Signatures (v5.1) 1.032E-9 2.043E-7 1.927E-6 7.224E-6 17 200
36 M13867 Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.051E-9 2.043E-7 1.927E-6 7.356E-6 19 256
37 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.362E-9 2.577E-7 2.430E-6 9.534E-6 19 260
38 M12432 Genes down-regulated in unstable ateroslerotic plaques compared to the stable ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.337E-9 6.149E-7 5.799E-6 2.337E-5 9 43
39 M18086 'Cancer prone response profile' (CPRP): genes common to estradiol and bisphenol A [PubChem=5757;6623] response of epithelial cell cultures from patients at high risk of breast cancer. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.308E-9 7.735E-7 7.295E-6 3.017E-5 13 118
40 M2779 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 and PCGF2 [Gene ID=648, 7703] genes by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 6.147E-9 1.076E-6 1.015E-5 4.304E-5 14 145
41 M19128 Genes down-regulated in tumor-conditioned vs quiescent endothelial cells and up-regulated upon treatment with decitabine and TSA [PubChem=451668;5562]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.435E-9 1.099E-6 1.037E-5 4.506E-5 11 80
42 M2769 Genes down-regulated during early stages of differentiation of embryoid bodies from V6.5 embryonic stem cells. MSigDB C6: Oncogenic Signatures (v5.1) 7.125E-9 1.188E-6 1.120E-5 4.989E-5 15 172
43 M14385 Genes down-regulated in fibroblasts with defective XPC [GeneID=7508] in response to cisplatin [PubChem=2767]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.568E-9 1.232E-6 1.162E-5 5.299E-5 17 228
44 M13206 Genes down-regulated in TC71 and EWS502 cells (Ewing's sarcoma) by EWSR1-FLI1 [GeneID=2130;2314] as inferred from RNAi knockdown of this fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.008E-8 1.604E-6 1.513E-5 7.057E-5 20 326
45 M12602 Genes positively correlated with recurrence free survival in patients with hepatitis B-related (HBV) hepatocellular carcinoma (HCC). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.126E-8 1.752E-6 1.653E-5 7.885E-5 12 105
46 M12621 Genes up-regulated in Wilm's tumor samples compared to fetal kidney. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.536E-8 2.338E-6 2.205E-5 1.075E-4 15 182
47 M2001 Genes associated with migration rate of 40 human bladder cancer cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.780E-8 2.652E-6 2.501E-5 1.246E-4 15 184
48 M1614 Genes down-regulated in RMS cells (rhabdomyosarcoma) expressing PAX3 or PAX7 fusions with FOXO1 [GeneID=5077;5081;2308] compared to the fusion negative cell lines. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.980E-8 2.889E-6 2.724E-5 1.387E-4 6 15
49 M2307 Representative genes up-regulated in C2C12 cells (myoblast) lacking NFkB activity due to expression of a super repressor form of NFKBIA [GeneID=4792]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.170E-8 3.101E-6 2.925E-5 1.520E-4 7 25
50 M2395 Genes up-regulated in pancreatic islets upon knockout of HNF1A [GeneID=6927]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.769E-8 3.878E-6 3.657E-5 1.939E-4 14 163
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 3805 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 1.094E-32 3.520E-29 3.105E-28 4.162E-29 53 494
2 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 500 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.850E-32 3.520E-29 3.105E-28 7.040E-29 48 388
3 gudmap developingLowerUrinaryTract P1 bladder J 1000 k2 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.003E-26 1.272E-23 1.122E-22 3.815E-23 36 251
4 gudmap developingLowerUrinaryTract P1 bladder 500 J DevelopingLowerUrinaryTract P1 bladder J emap-30374 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.451E-26 5.185E-23 4.574E-22 2.074E-22 42 390
5 gudmap developingLowerUrinaryTract P1 bladder B 1000 k1 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.580E-23 1.202E-20 1.061E-19 6.012E-20 30 192
6 geo heart 1000 K5 geo heart top-relative-expression-ranked 1000 k-means-cluster#5 PCBC 2.034E-23 1.256E-20 1.108E-19 7.740E-20 41 428
7 80Dn Top 500 Cluster 2 80Dn Top 500 Cluster 2 Brain Map - Allen iN 2.311E-23 1.256E-20 1.108E-19 8.793E-20 32 231
8 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 1000 k1 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.436E-21 6.829E-19 6.024E-18 5.463E-18 31 243
9 PCBC ctl geo-heart 500 geo heart top-relative-expression-ranked 500 PCBC 6.585E-21 2.784E-18 2.456E-17 2.506E-17 41 499
10 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 500 k3 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.995E-21 3.042E-18 2.684E-17 3.042E-17 23 115
11 gudmap developingLowerUrinaryTract P1 ureter 1000 k2 DevelopingLowerUrinaryTract P1 ureter emap-30363 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.555E-20 5.380E-18 4.746E-17 5.918E-17 27 184
12 gudmap developingKidney e15.5 Ureteral Smooth Musc 500 k5 DevelopingKidney e15.5 Ureteral Smooth Musc emap-28812 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.404E-20 7.623E-18 6.725E-17 9.148E-17 27 187
13 gudmap developingLowerUrinaryTract P1 bladder 500 B DevelopingLowerUrinaryTract P1 bladder B emap-30374 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.730E-20 7.991E-18 7.049E-17 1.039E-16 36 385
14 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 500 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.589E-19 4.200E-17 3.705E-16 6.046E-16 36 406
15 gudmap developingKidney e15.5 Ureteral Smooth Musc 200 DevelopingKidney e15.5 Ureteral Smooth Musc emap-28812 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.656E-19 4.200E-17 3.705E-16 6.300E-16 25 164
16 gudmap developingKidney e15.5 Ureteral Smooth Musc 200 k3 DevelopingKidney e15.5 Ureteral Smooth Musc emap-28812 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.934E-19 4.598E-17 4.056E-16 7.357E-16 20 88
17 gudmap dev gonad e13.5 M InterstitTestis Sma 500 dev gonad e13.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.870E-19 6.423E-17 5.666E-16 1.092E-15 34 362
18 gudmap developingLowerUrinaryTract P1 bladder J 500 k4 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.319E-19 7.016E-17 6.189E-16 1.263E-15 21 104
19 gudmap developingLowerUrinaryTract e14.5 urethra 1000 k1 DevelopingLowerUrinaryTract e14.5 urethra emap-30892 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.009E-19 1.003E-16 8.849E-16 1.906E-15 20 92
20 gudmap kidney P0 JuxtaGlom Ren1 500 kidney P0 JuxtaGlom Ren1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.453E-19 1.798E-16 1.586E-15 3.597E-15 37 456
21 gudmap developingLowerUrinaryTract adult bladder 500 DevelopingLowerUrinaryTract adult bladder emap-29457 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.209E-18 2.191E-16 1.933E-15 4.601E-15 34 379
22 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.771E-18 3.062E-16 2.701E-15 6.737E-15 35 410
23 gudmap developingLowerUrinaryTract adult bladder 1000 k1 DevelopingLowerUrinaryTract adult bladder emap-29457 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.131E-18 5.180E-16 4.569E-15 1.191E-14 23 148
24 gudmap developingKidney e15.5 Ureteral Smooth Musc 1000 k2 DevelopingKidney e15.5 Ureteral Smooth Musc emap-28812 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.724E-18 5.686E-16 5.015E-15 1.417E-14 29 270
25 gudmap developingKidney e15.5 Ureteral Smooth Musc 500 DevelopingKidney e15.5 Ureteral Smooth Musc emap-28812 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.736E-18 5.686E-16 5.015E-15 1.421E-14 34 393
26 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 5.669E-18 8.296E-16 7.318E-15 2.157E-14 36 453
27 gudmap kidney adult Mesangium Meis 500 kidney adult Mesangium Meis top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.435E-18 1.048E-15 9.243E-15 2.829E-14 35 429
28 gudmap developingLowerUrinaryTract e13.5 bladder mesenchyme 1000 k3 DevelopingLowerUrinaryTract e13.5 bladder mesenchyme emap-3087 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.632E-17 2.217E-15 1.956E-14 6.208E-14 23 159
29 DevelopingLowerUrinaryTract e14.5 bladder emap-6668 k4 1000 DevelopingLowerUrinaryTract e14.5 bladder emap-6668 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.083E-17 2.733E-15 2.411E-14 7.926E-14 19 95
30 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 200 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.308E-17 4.196E-15 3.701E-14 1.259E-13 23 164
31 gudmap kidney P0 JuxtaGlom Ren1 k3 1000 kidney P0 JuxtaGlom Ren1 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.461E-17 4.248E-15 3.748E-14 1.317E-13 29 293
32 gudmap developingLowerUrinaryTract P1 bladder B 500 k2 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.322E-17 6.328E-15 5.582E-14 2.025E-13 20 115
33 gudmap developingLowerUrinaryTract P2 bladder stroma (LCM) 1000 k3 DevelopingLowerUrinaryTract P2 bladder stroma (LCM) emap-30396 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.539E-17 6.386E-15 5.634E-14 2.108E-13 26 229
34 80Dn SubClass 80Dn 1 Top 500 All 80Dn SubClass 80Dn 1 Top 500 All Brain Map - Allen iN 6.549E-17 7.120E-15 6.281E-14 2.492E-13 36 489
35 80Dn SubClass 80Dn 1 Top 500 Cluster 0 80Dn SubClass 80Dn 1 Top 500 Cluster 0 Brain Map - Allen iN 6.549E-17 7.120E-15 6.281E-14 2.492E-13 36 489
36 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 1.035E-16 1.094E-14 9.650E-14 3.938E-13 34 438
37 BM Top 100 - skeletal muscle BM Top 100 - skeletal muscle Body Map 1.098E-16 1.129E-14 9.958E-14 4.177E-13 17 75
38 gudmap dev gonad e13.5 M InterstitFLeydig MafB k3 1000 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.669E-16 1.671E-14 1.474E-13 6.352E-13 30 336
39 Lungmap Mouse e16.5 Myofibro Top 500 All Lungmap Mouse e16.5 Myofibro Top 500 All Lungmap Mouse Single Cell (Lungmap.net) 2.114E-16 2.025E-14 1.786E-13 8.043E-13 33 420
40 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 1000 k2 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.182E-16 2.025E-14 1.786E-13 8.301E-13 19 107
41 gudmap developingLowerUrinaryTract adult bladder 500 k4 DevelopingLowerUrinaryTract adult bladder emap-29457 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.182E-16 2.025E-14 1.786E-13 8.301E-13 19 107
42 gudmap dev gonad e13.5 M InterstitFLeydig MafB k4 500 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.471E-16 3.144E-14 2.774E-13 1.321E-12 23 182
43 gudmap dev gonad e11.5 F GonMes Sma k4 1000 dev gonad e11.5 F GonMes Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 7.105E-16 6.287E-14 5.546E-13 2.704E-12 29 328
44 gudmap dev gonad e13.5 M InterstitFLeydig MafB 500 dev gonad e13.5 M InterstitFLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.095E-16 7.000E-14 6.175E-13 3.080E-12 30 356
45 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 500 k5 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 8.602E-16 7.273E-14 6.416E-13 3.273E-12 14 47
46 gudmap dev gonad e12.5 M InterstitLeydig MafB k1 1000 dev gonad e12.5 M InterstitLeydig MafB k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.449E-15 1.199E-13 1.057E-12 5.514E-12 28 311
47 gudmap developingLowerUrinaryTract P1 bladder J 500 k2 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.621E-15 2.122E-13 1.871E-12 9.971E-12 18 105
48 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 k2 1000 dev lower uro neuro e14.5 PelvicGanglion Sox10 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.242E-15 2.570E-13 2.267E-12 1.234E-11 15 63
49 BM Top 100 - heart atrium BM Top 100 - heart atrium Body Map 6.014E-15 4.670E-13 4.120E-12 2.288E-11 16 79
50 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 7.617E-15 5.797E-13 5.113E-12 2.898E-11 32 445
Show 45 more annotations

15: Computational [Display Chart] 446 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 329 Genes in module 329 MSigDb: C4 - CM: Cancer Modules 5.896E-13 2.630E-10 1.756E-9 2.630E-10 14 51
2 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 1.997E-12 3.231E-10 2.158E-9 8.905E-10 32 378
3 module 202 Genes in module 202 MSigDb: C4 - CM: Cancer Modules 2.173E-12 3.231E-10 2.158E-9 9.692E-10 11 28
4 module 387 Genes in module 387 MSigDb: C4 - CM: Cancer Modules 6.610E-12 7.370E-10 4.922E-9 2.948E-9 13 49
5 module 201 Genes in module 201 MSigDb: C4 - CM: Cancer Modules 8.780E-12 7.832E-10 5.230E-9 3.916E-9 13 50
6 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 4.479E-11 3.329E-9 2.223E-8 1.998E-8 29 351
7 module 512 Genes in module 512 MSigDb: C4 - CM: Cancer Modules 7.410E-11 4.721E-9 3.153E-8 3.305E-8 11 37
8 GNF2 MYL2 Neighborhood of MYL2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.199E-10 1.783E-8 1.191E-7 1.427E-7 10 32
9 GNF2 TTN Neighborhood of TTN MSigDb: C4 - CGN: Cancer Gene Neighborhood 8.969E-10 4.444E-8 2.968E-7 4.000E-7 9 26
10 GNF2 MYL3 Neighborhood of MYL3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.313E-9 2.370E-7 1.583E-6 2.370E-6 9 31
11 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 8.529E-9 3.458E-7 2.310E-6 3.804E-6 20 216
12 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 9.385E-9 3.488E-7 2.330E-6 4.186E-6 26 361
13 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 6.068E-8 2.082E-6 1.390E-5 2.707E-5 27 423
14 module 33 Genes in module 33 MSigDb: C4 - CM: Cancer Modules 2.918E-7 9.297E-6 6.209E-5 1.302E-4 24 372
15 module 330 Genes in module 330 MSigDb: C4 - CM: Cancer Modules 8.844E-7 2.630E-5 1.756E-4 3.944E-4 7 28
16 module 60 Genes in module 60 MSigDb: C4 - CM: Cancer Modules 1.881E-5 5.244E-4 3.503E-3 8.391E-3 22 410
17 module 220 Genes in module 220 MSigDb: C4 - CM: Cancer Modules 2.546E-5 6.516E-4 4.352E-3 1.136E-2 19 328
18 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 2.630E-5 6.516E-4 4.352E-3 1.173E-2 22 419
19 module 38 Genes in module 38 MSigDb: C4 - CM: Cancer Modules 3.108E-5 7.295E-4 4.872E-3 1.386E-2 23 455
20 module 19 Genes in module 19 MSigDb: C4 - CM: Cancer Modules 3.582E-5 7.987E-4 5.334E-3 1.597E-2 18 307
21 module 44 Genes in module 44 MSigDb: C4 - CM: Cancer Modules 5.917E-5 1.257E-3 8.393E-3 2.639E-2 18 319
22 module 128 Genes in module 128 MSigDb: C4 - CM: Cancer Modules 1.326E-4 2.688E-3 1.795E-2
5.913E-2
9 98
23 module 79 Genes in module 79 MSigDb: C4 - CM: Cancer Modules 1.549E-4 2.879E-3 1.923E-2
6.910E-2
9 100
24 module 170 Genes in module 170 MSigDb: C4 - CM: Cancer Modules 1.549E-4 2.879E-3 1.923E-2
6.910E-2
9 100
25 module 524 Genes in module 524 MSigDb: C4 - CM: Cancer Modules 2.742E-4 4.891E-3 3.266E-2
1.223E-1
5 30
26 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 8.183E-4 1.404E-2
9.375E-2
3.650E-1
18 395
27 module 6 Genes in module 6 MSigDb: C4 - CM: Cancer Modules 1.153E-3 1.904E-2
1.272E-1
5.142E-1
18 407
28 module 3 Genes in module 3 MSigDb: C4 - CM: Cancer Modules 1.210E-3 1.927E-2
1.287E-1
5.396E-1
17 375
29 module 223 Genes in module 223 MSigDb: C4 - CM: Cancer Modules 1.814E-3 2.790E-2
1.863E-1
8.091E-1
9 140
30 module 121 Genes in module 121 MSigDb: C4 - CM: Cancer Modules 3.227E-3 4.798E-2
3.204E-1
1.000E0
7 98
Show 25 more annotations

16: MicroRNA [Display Chart] 1419 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-320c:PITA hsa-miR-320c:PITA TOP PITA 2.194E-8 7.783E-6 6.098E-5 3.113E-5 25 481
2 hsa-miR-320a:PITA hsa-miR-320a:PITA TOP PITA 2.194E-8 7.783E-6 6.098E-5 3.113E-5 25 481
3 hsa-miR-320b:PITA hsa-miR-320b:PITA TOP PITA 2.194E-8 7.783E-6 6.098E-5 3.113E-5 25 481
4 hsa-miR-320d:PITA hsa-miR-320d:PITA TOP PITA 2.194E-8 7.783E-6 6.098E-5 3.113E-5 25 481
5 hsa-miR-217:TargetScan hsa-miR-217:TargetScan TargetScan 2.660E-7 7.548E-5 5.914E-4 3.774E-4 16 237
6 hsa-miR-892a:PITA hsa-miR-892a:PITA TOP PITA 1.017E-6 2.140E-4 1.677E-3 1.443E-3 16 262
7 hsa-miR-363:PITA hsa-miR-363:PITA TOP PITA 1.624E-6 2.140E-4 1.677E-3 2.305E-3 22 486
8 hsa-miR-25:PITA hsa-miR-25:PITA TOP PITA 1.680E-6 2.140E-4 1.677E-3 2.384E-3 22 487
9 hsa-miR-92a:PITA hsa-miR-92a:PITA TOP PITA 1.680E-6 2.140E-4 1.677E-3 2.384E-3 22 487
10 hsa-miR-367:PITA hsa-miR-367:PITA TOP PITA 1.680E-6 2.140E-4 1.677E-3 2.384E-3 22 487
11 hsa-miR-92b:PITA hsa-miR-92b:PITA TOP PITA 1.680E-6 2.140E-4 1.677E-3 2.384E-3 22 487
12 hsa-miR-452:PITA hsa-miR-452:PITA TOP PITA 1.810E-6 2.140E-4 1.677E-3 2.568E-3 21 451
13 hsa-miR-1261:PITA hsa-miR-1261:PITA TOP PITA 5.574E-6 6.084E-4 4.767E-3 7.909E-3 14 232
14 hsa-miR-1279:PITA hsa-miR-1279:PITA TOP PITA 7.470E-6 7.571E-4 5.932E-3 1.060E-2 14 238
15 CAGCTTT,MIR-320:MSigDB CAGCTTT,MIR-320:MSigDB MSigDB 8.218E-6 7.774E-4 6.091E-3 1.166E-2 14 240
16 hsa-miR-382:PITA hsa-miR-382:PITA TOP PITA 9.174E-6 8.136E-4 6.375E-3 1.302E-2 15 276
17 hsa-miR-127-5p:PITA hsa-miR-127-5p:PITA TOP PITA 1.192E-5 9.949E-4 7.795E-3 1.691E-2 14 248
18 hsa-miR-942:PITA hsa-miR-942:PITA TOP PITA 1.474E-5 1.127E-3 8.829E-3 2.092E-2 16 323
19 hsa-miR-143:PITA hsa-miR-143:PITA TOP PITA 1.509E-5 1.127E-3 8.829E-3 2.141E-2 13 220
20 hsa-miR-32:PITA hsa-miR-32:PITA TOP PITA 1.645E-5 1.167E-3 9.145E-3 2.334E-2 20 480
21 miR-32:PicTar miR-32:PicTar PicTar 1.861E-5 1.237E-3 9.695E-3 2.640E-2 19 444
22 hsa-miR-22:TargetScan hsa-miR-22:TargetScan TargetScan 1.918E-5 1.237E-3 9.695E-3 2.722E-2 16 330
23 CTTTGTA,MIR-524:MSigDB CTTTGTA,MIR-524:MSigDB MSigDB 2.138E-5 1.319E-3 1.033E-2 3.033E-2 18 409
24 miR-367:PicTar miR-367:PicTar PicTar 2.390E-5 1.413E-3 1.107E-2 3.392E-2 16 336
25 hsa-miR-653:PITA hsa-miR-653:PITA TOP PITA 3.080E-5 1.748E-3 1.370E-2 4.370E-2 15 306
26 TTTGTAG,MIR-520D:MSigDB TTTGTAG,MIR-520D:MSigDB MSigDB 3.576E-5 1.952E-3 1.529E-2
5.074E-2
15 310
27 miR-101:PicTar miR-101:PicTar PicTar 4.121E-5 2.166E-3 1.697E-2
5.848E-2
18 430
28 hsa-miR-516a-3p:PITA hsa-miR-516a-3p:PITA TOP PITA 4.885E-5 2.248E-3 1.762E-2
6.932E-2
12 212
29 AATGTGA,MIR-23A:MSigDB AATGTGA,MIR-23A:MSigDB MSigDB 4.939E-5 2.248E-3 1.762E-2
7.009E-2
17 396
30 AATGTGA,MIR-23B:MSigDB AATGTGA,MIR-23B:MSigDB MSigDB 4.939E-5 2.248E-3 1.762E-2
7.009E-2
17 396
31 hsa-miR-140-5p:PITA hsa-miR-140-5p:PITA TOP PITA 5.124E-5 2.248E-3 1.762E-2
7.272E-2
14 283
32 hsa-miR-182:PITA hsa-miR-182:PITA TOP PITA 5.216E-5 2.248E-3 1.762E-2
7.402E-2
19 479
33 hsa-miR-448:PITA hsa-miR-448:PITA TOP PITA 5.229E-5 2.248E-3 1.762E-2
7.419E-2
18 438
34 GACTGTT,MIR-132:MSigDB GACTGTT,MIR-132:MSigDB MSigDB 6.663E-5 2.701E-3 2.117E-2
9.455E-2
10 154
35 GACTGTT,MIR-212:MSigDB GACTGTT,MIR-212:MSigDB MSigDB 6.663E-5 2.701E-3 2.117E-2
9.455E-2
10 154
36 hsa-miR-575:PITA hsa-miR-575:PITA TOP PITA 7.474E-5 2.927E-3 2.294E-2
1.061E-1
11 188
37 ACTGAAA,MIR-30E-3P:MSigDB ACTGAAA,MIR-30E-3P:MSigDB MSigDB 7.839E-5 2.927E-3 2.294E-2
1.112E-1
11 189
38 ACTGAAA,MIR-30A-3P:MSigDB ACTGAAA,MIR-30A-3P:MSigDB MSigDB 7.839E-5 2.927E-3 2.294E-2
1.112E-1
11 189
39 miR-92:PicTar miR-92:PicTar PicTar 8.275E-5 2.942E-3 2.305E-2
1.174E-1
17 413
40 miR-139:PicTar miR-139:PicTar PicTar 8.293E-5 2.942E-3 2.305E-2
1.177E-1
12 224
41 hsa-miR-621:PITA hsa-miR-621:PITA TOP PITA 9.020E-5 3.046E-3 2.387E-2
1.280E-1
8 101
42 hsa-miR-374b:TargetScan hsa-miR-374b:TargetScan TargetScan 9.230E-5 3.046E-3 2.387E-2
1.310E-1
18 458
43 hsa-miR-374a:TargetScan hsa-miR-374a:TargetScan TargetScan 9.230E-5 3.046E-3 2.387E-2
1.310E-1
18 458
44 hsa-miR-204:TargetScan hsa-miR-204:TargetScan TargetScan 1.002E-4 3.160E-3 2.476E-2
1.422E-1
18 461
45 hsa-miR-211:TargetScan hsa-miR-211:TargetScan TargetScan 1.002E-4 3.160E-3 2.476E-2
1.422E-1
18 461
46 miR-23a:PicTar miR-23a:PicTar PicTar 1.074E-4 3.243E-3 2.541E-2
1.524E-1
17 422
47 miR-199a-star:PicTar miR-199a-star:PicTar PicTar 1.074E-4 3.243E-3 2.541E-2
1.524E-1
17 422
48 miR-23b:PicTar miR-23b:PicTar PicTar 1.137E-4 3.361E-3 2.634E-2
1.613E-1
17 424
49 hsa-miR-1304:PITA hsa-miR-1304:PITA TOP PITA 1.190E-4 3.446E-3 2.700E-2
1.688E-1
9 134
50 miR-214:PicTar miR-214:PicTar PicTar 1.237E-4 3.452E-3 2.704E-2
1.756E-1
17 427
Show 45 more annotations

17: Drug [Display Chart] 23021 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 D013096 Spermine CTD 7.701E-20 1.773E-15 1.883E-14 1.773E-15 18 63
2 CID000008330 TCNB Stitch 5.663E-17 6.518E-13 6.923E-12 1.304E-12 20 119
3 D008942 Mitoxantrone CTD 1.350E-13 1.036E-9 1.101E-8 3.109E-9 23 247
4 C488369 dasatinib CTD 3.374E-12 1.723E-8 1.830E-7 7.767E-8 29 472
5 D000069439 Dasatinib CTD 3.742E-12 1.723E-8 1.830E-7 8.616E-8 29 474
6 C017557 nickel subsulfide CTD 3.153E-11 1.210E-7 1.285E-6 7.259E-7 18 185
7 CID005288569 AC1NRBPQ Stitch 2.707E-10 8.904E-7 9.457E-6 6.233E-6 15 137
8 D010656 Phenylephrine CTD 3.553E-10 1.022E-6 1.086E-5 8.180E-6 27 500
9 C543008 bis(4-hydroxyphenyl)sulfone CTD 5.524E-10 1.413E-6 1.501E-5 1.272E-5 16 168
10 CID000486033 SM-2 Stitch 1.164E-9 2.474E-6 2.628E-5 2.680E-5 12 87
11 CID000084102 To 2 Stitch 1.182E-9 2.474E-6 2.628E-5 2.722E-5 11 69
12 CID000024008 fast white Stitch 2.514E-9 4.822E-6 5.122E-5 5.787E-5 9 42
13 C032910 triadimefon CTD 3.291E-9 5.828E-6 6.190E-5 7.576E-5 22 373
14 CID006398969 B0683 Stitch 3.575E-9 5.851E-6 6.214E-5 8.229E-5 13 117
15 CID000006035 bromodeoxyuridine Stitch 3.812E-9 5.851E-6 6.214E-5 8.776E-5 22 376
16 2132 UP Xylazine [7361-61-7]; Up 200; 18.2uM; HL60; HT HG-U133A Broad Institute CMAP 4.890E-9 7.035E-6 7.473E-5 1.126E-4 16 195
17 CID000122259 NpCaM Stitch 8.841E-9 1.197E-5 1.272E-4 2.035E-4 9 48
18 CID000486032 AC1LADJ6 Stitch 1.303E-8 1.666E-5 1.770E-4 2.999E-4 13 130
19 CID005281701 tricetin Stitch 1.453E-8 1.761E-5 1.871E-4 3.346E-4 8 36
20 D001374 Azacitidine CTD 1.604E-8 1.846E-5 1.961E-4 3.692E-4 22 407
21 C010063 carbonyl sulfide CTD 1.881E-8 2.062E-5 2.191E-4 4.331E-4 13 134
22 CID000146339 DAPs Stitch 2.686E-8 2.810E-5 2.985E-4 6.183E-4 11 92
23 D001761 Bleomycin CTD 2.811E-8 2.813E-5 2.988E-4 6.470E-4 22 420
24 MESH:D002311/D004317-M Cardiomyopathy, Dilated affected by Doxorubicin CTD Marker 3.009E-8 2.846E-5 3.022E-4 6.926E-4 6 16
25 6100 UP Phenazopyridine hydrochloride [136-40-3]; Up 200; 16uM; MCF7; HT HG-U133A Broad Institute CMAP 3.090E-8 2.846E-5 3.022E-4 7.114E-4 15 193
26 3738 UP Benzamil hydrochloride [2898-76-2]; Up 200; 11.2uM; PC3; HT HG-U133A Broad Institute CMAP 3.796E-8 3.269E-5 3.472E-4 8.740E-4 15 196
27 D015056 1-Methyl-3-isobutylxanthine CTD 3.834E-8 3.269E-5 3.472E-4 8.826E-4 21 391
28 C487049 BXL628 CTD 4.600E-8 3.566E-5 3.787E-4 1.059E-3 6 17
29 CID000005566 trifluoperazine Stitch 4.606E-8 3.566E-5 3.787E-4 1.060E-3 19 325
30 2379 UP Trazodone hydrochloride [25332-39-2]; Up 200; 9.8uM; HL60; HT HG-U133A Broad Institute CMAP 4.647E-8 3.566E-5 3.787E-4 1.070E-3 15 199
31 3044 UP 3-Acetylcoumarin [3949-36-8]; Up 200; 21.2uM; HL60; HT HG-U133A Broad Institute CMAP 4.966E-8 3.688E-5 3.917E-4 1.143E-3 15 200
32 4112 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 5.405E-8 3.889E-5 4.130E-4 1.244E-3 14 173
33 C577942 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide CTD 1.060E-7 7.397E-5 7.857E-4 2.441E-3 7 31
34 C568713 GSK1210151A CTD 1.122E-7 7.595E-5 8.067E-4 2.582E-3 8 46
35 D002235 Carbofuran CTD 1.214E-7 7.982E-5 8.478E-4 2.794E-3 10 84
36 D008558 Melphalan CTD 1.258E-7 8.042E-5 8.541E-4 2.895E-3 17 278
37 5958 UP 17-AAG; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 1.428E-7 8.883E-5 9.435E-4 3.287E-3 14 187
38 2208 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP 1.525E-7 9.239E-5 9.813E-4 3.511E-3 14 188
39 CID000008202 methyl 9-octadecenoate Stitch 2.091E-7 1.235E-4 1.311E-3 4.815E-3 11 112
40 CID000220461 NSC3260 Stitch 2.392E-7 1.355E-4 1.439E-3 5.507E-3 14 195
41 5000 UP Amethopterin (R,S) [59-05-2]; Up 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP 2.547E-7 1.355E-4 1.439E-3 5.864E-3 14 196
42 4415 UP Etilefrine hydrochloride [534-87-2]; Up 200; 18.4uM; MCF7; HT HG-U133A Broad Institute CMAP 2.547E-7 1.355E-4 1.439E-3 5.864E-3 14 196
43 6677 UP Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; PC3; HT HG-U133A Broad Institute CMAP 2.554E-7 1.355E-4 1.439E-3 5.880E-3 13 167
44 CID000508110 AC1LA6KT Stitch 2.590E-7 1.355E-4 1.439E-3 5.962E-3 8 51
45 5202 UP ICI 182,780; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP 2.711E-7 1.357E-4 1.441E-3 6.241E-3 14 197
46 4121 UP Ginkgolide A [15291-75-5]; Up 200; 9.8uM; MCF7; HT HG-U133A Broad Institute CMAP 2.711E-7 1.357E-4 1.441E-3 6.241E-3 14 197
47 C001277 geldanamycin CTD 2.926E-7 1.358E-4 1.442E-3 6.736E-3 19 366
48 CID000002783 clenbuterol Stitch 3.059E-7 1.358E-4 1.442E-3 7.042E-3 12 142
49 3777 UP 0317956-0000 [391210-11-0]; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 3.067E-7 1.358E-4 1.442E-3 7.061E-3 14 199
50 4389 UP Sulpiride [15676-16-1]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP 3.067E-7 1.358E-4 1.442E-3 7.061E-3 14 199
Show 45 more annotations

18: Disease [Display Chart] 2718 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0270960 Congenital myopathy (disorder) DisGeNET BeFree 7.043E-17 1.914E-13 1.624E-12 1.914E-13 14 36
2 umls:C0026848 Myopathy DisGeNET Curated 2.356E-16 3.202E-13 2.717E-12 6.404E-13 29 277
3 umls:C0949658 Cardiomyopathy, Hypertrophic, Familial DisGeNET Curated 3.573E-16 3.237E-13 2.747E-12 9.712E-13 15 49
4 umls:C0878544 Cardiomyopathies DisGeNET Curated 4.229E-13 2.873E-10 2.438E-9 1.149E-9 31 424
5 cv:C0007193 Primary dilated cardiomyopathy Clinical Variations 3.765E-12 2.047E-9 1.737E-8 1.023E-8 10 27
6 umls:C0751336 Distal Muscular Dystrophies DisGeNET Curated 5.536E-12 2.508E-9 2.128E-8 1.505E-8 9 20
7 umls:C0686353 Muscular Dystrophies, Limb-Girdle DisGeNET Curated 6.686E-12 2.596E-9 2.203E-8 1.817E-8 12 49
8 umls:C0007194 Hypertrophic Cardiomyopathy DisGeNET Curated 7.793E-12 2.648E-9 2.247E-8 2.118E-8 19 165
9 umls:C0340427 Familial dilated cardiomyopathy DisGeNET Curated 3.066E-11 9.259E-9 7.856E-8 8.333E-8 11 43
10 umls:C0007193 Cardiomyopathy, Dilated DisGeNET Curated 7.076E-11 1.923E-8 1.632E-7 1.923E-7 26 366
11 umls:C0206157 Myopathies, Nemaline DisGeNET Curated 2.929E-10 7.237E-8 6.141E-7 7.961E-7 9 29
12 umls:C0151786 Muscle Weakness DisGeNET Curated 3.207E-10 7.264E-8 6.163E-7 8.716E-7 19 204
13 umls:C1533847 Disorder of skeletal muscle DisGeNET BeFree 1.006E-8 2.103E-6 1.785E-5 2.734E-5 6 12
14 umls:C0030552 Paresis DisGeNET Curated 1.108E-8 2.151E-6 1.825E-5 3.011E-5 13 109
15 umls:C2678065 Myofibrillar Myopathy DisGeNET BeFree 1.508E-8 2.732E-6 2.318E-5 4.098E-5 8 31
16 umls:C0035412 Rhabdomyosarcoma DisGeNET Curated 3.444E-8 5.850E-6 4.964E-5 9.360E-5 22 360
17 umls:C0917713 Becker Muscular Dystrophy DisGeNET Curated 1.196E-7 1.913E-5 1.623E-4 3.252E-4 7 27
18 umls:C3495498 Cardiomyopathy, Familial Hypertrophic, 1 (disorder) DisGeNET Curated 3.376E-7 5.097E-5 4.325E-4 9.175E-4 5 11
19 umls:C0027868 Neuromuscular Diseases DisGeNET Curated 4.582E-7 6.555E-5 5.562E-4 1.245E-3 10 82
20 umls:C1960469 Left ventricular noncompaction DisGeNET Curated 5.265E-7 7.155E-5 6.071E-4 1.431E-3 6 21
21 umls:C2936331 Sarcoglycanopathies DisGeNET Curated 5.715E-7 7.397E-5 6.276E-4 1.553E-3 5 12
22 umls:C0026850 Muscular Dystrophy DisGeNET Curated 1.148E-6 1.419E-4 1.204E-3 3.121E-3 15 216
23 umls:C0013264 Muscular Dystrophy, Duchenne DisGeNET Curated 1.213E-6 1.434E-4 1.216E-3 3.297E-3 11 113
24 192600 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC 1; CMH1 OMIM 1.774E-6 2.009E-4 1.705E-3 4.821E-3 4 7
25 umls:C0410174 Fukuyama Type Congenital Muscular Dystrophy DisGeNET Curated 4.195E-6 4.386E-4 3.721E-3 1.140E-2 5 17
26 umls:C1853926 NONAKA MYOPATHY DisGeNET Curated 4.195E-6 4.386E-4 3.721E-3 1.140E-2 5 17
27 umls:C0027626 Neoplasm Invasiveness DisGeNET Curated 5.602E-6 5.640E-4 4.785E-3 1.523E-2 11 132
28 umls:C0023267 Fibroid Tumor DisGeNET Curated 8.728E-6 8.473E-4 7.189E-3 2.372E-2 16 287
29 umls:C1837091 MYASTHENIC SYNDROME, CONGENITAL, ASSOCIATED WITH ACETYLCHOLINE RECEPTOR DEFICIENCY DisGeNET Curated 1.381E-5 1.294E-3 1.098E-2 3.753E-2 3 4
30 umls:C1511789 Desmoplastic DisGeNET BeFree 1.810E-5 1.615E-3 1.370E-2 4.920E-2 8 75
31 umls:C0018798 Congenital Heart Defects DisGeNET Curated 1.868E-5 1.615E-3 1.370E-2
5.078E-2
13 208
32 umls:C1145670 Respiratory Failure DisGeNET BeFree 1.901E-5 1.615E-3 1.370E-2
5.168E-2
7 55
33 umls:C0410226 Congenital Myotonic Dystrophy DisGeNET BeFree 2.281E-5 1.879E-3 1.594E-2
6.199E-2
11 153
34 umls:C0018799 Heart Diseases DisGeNET Curated 2.352E-5 1.880E-3 1.595E-2
6.393E-2
15 277
35 umls:C0027126 Myotonic Dystrophy DisGeNET Curated 2.574E-5 1.999E-3 1.696E-2
6.997E-2
11 155
36 umls:C0036857 Severe mental retardation (I.Q. 20-34) DisGeNET Curated 3.035E-5 2.292E-3 1.944E-2
8.250E-2
7 59
37 umls:C0026846 Muscular Atrophy DisGeNET Curated 3.260E-5 2.379E-3 2.019E-2
8.862E-2
11 159
38 umls:C1853698 Rippling muscle disease DisGeNET Curated 3.413E-5 2.379E-3 2.019E-2
9.278E-2
3 5
39 608931 MYASTHENIC SYNDROME, CONGENITAL, ASSOCIATED WITH ACETYLCHOLINE RECEPTOR DEFICIENCY OMIM 3.413E-5 2.379E-3 2.019E-2
9.278E-2
3 5
40 umls:C0042133 Uterine Fibroids DisGeNET Curated 3.873E-5 2.632E-3 2.233E-2
1.053E-1
16 324
41 umls:C1837249 Malformations of Cortical Development, Group II DisGeNET BeFree 3.987E-5 2.643E-3 2.242E-2
1.084E-1
5 26
42 umls:C0745103 Hyperlipoproteinemia Type IIa DisGeNET Curated 4.468E-5 2.892E-3 2.454E-2
1.214E-1
6 43
43 umls:C2697932 Loeys-Dietz Syndrome DisGeNET Curated 4.664E-5 2.948E-3 2.501E-2
1.268E-1
4 14
44 umls:C0848332 Spots on skin DisGeNET BeFree 5.290E-5 3.268E-3 2.773E-2
1.438E-1
12 198
45 umls:C0238190 Inclusion Body Myositis (disorder) DisGeNET Curated 5.732E-5 3.462E-3 2.938E-2
1.558E-1
7 65
46 umls:C0334488 Clear cell sarcoma of kidney DisGeNET BeFree 6.284E-5 3.713E-3 3.150E-2
1.708E-1
4 15
47 umls:C1838254 RIPPLING MUSCLE DISEASE 1 DisGeNET Curated 6.750E-5 3.904E-3 3.312E-2
1.835E-1
3 6
48 umls:C0270726 Alexander Disease DisGeNET Curated 8.278E-5 4.687E-3 3.977E-2
2.250E-1
4 16
49 umls:C1449563 Cardiomyopathy, Familial Idiopathic DisGeNET Curated 8.658E-5 4.802E-3 4.075E-2
2.353E-1
11 177
50 umls:C0349788 Arrhythmogenic Right Ventricular Dysplasia DisGeNET Curated 1.066E-4 5.569E-3 4.726E-2
2.896E-1
6 50
Show 45 more annotations