Toppgene analysis for aggregated_1964_log, IC8, negative side

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1: GO: Molecular Function [Display Chart] 287 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005539 glycosaminoglycan binding 9.025E-8 2.590E-5 1.616E-4 2.590E-5 9 219
2 GO:1901681 sulfur compound binding 4.306E-6 6.179E-4 3.855E-3 1.236E-3 8 260
3 GO:0019838 growth factor binding 1.237E-5 1.183E-3 7.382E-3 3.550E-3 6 142
4 GO:0004857 enzyme inhibitor activity 8.338E-5 5.982E-3 3.732E-2 2.393E-2 8 393
5 GO:0038085 vascular endothelial growth factor binding 1.278E-4 6.111E-3 3.812E-2 3.666E-2 2 5
6 GO:0051575 5'-deoxyribose-5-phosphate lyase activity 1.278E-4 6.111E-3 3.812E-2 3.666E-2 2 5
7 GO:0005201 extracellular matrix structural constituent 1.818E-4 6.859E-3 4.279E-2
5.219E-2
 4 78
8 GO:0045545 syndecan binding 1.912E-4 6.859E-3 4.279E-2
5.487E-2
 2 6
9 GO:0005021 vascular endothelial growth factor-activated receptor activity 2.670E-4 8.515E-3
5.312E-2
7.664E-2
 2 7
10 GO:0019199 transmembrane receptor protein kinase activity 3.289E-4 9.268E-3
5.781E-2
9.440E-2
 4 91
11 GO:0031995 insulin-like growth factor II binding 3.552E-4 9.268E-3
5.781E-2
1.019E-1
 2 8
12 GO:0004867 serine-type endopeptidase inhibitor activity 4.033E-4 9.647E-3
6.018E-2
1.158E-1
 4 96
13 GO:0003680 AT DNA binding 4.556E-4 1.006E-2
6.275E-2
1.308E-1
 2 9
14 GO:0030235 nitric-oxide synthase regulator activity 5.682E-4 1.165E-2
7.267E-2
1.631E-1
 2 10
15 GO:0031994 insulin-like growth factor I binding 8.295E-4 1.587E-2
9.901E-2
2.381E-1
 2 12
16 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity 1.138E-3 2.042E-2
1.274E-1
3.267E-1
 2 14
17 GO:0061134 peptidase regulator activity 1.270E-3 2.144E-2
1.337E-1
3.645E-1
 5 223
18 GO:0004714 transmembrane receptor protein tyrosine kinase activity 1.832E-3 2.921E-2
1.823E-1
5.259E-1
 3 67
19 GO:0008201 heparin binding 3.133E-3 3.841E-2
2.396E-1
8.992E-1
 4 167
20 GO:0004866 endopeptidase inhibitor activity 3.410E-3 3.841E-2
2.396E-1
9.788E-1
 4 171
21 GO:0005018 platelet-derived growth factor alpha-receptor activity 3.613E-3 3.841E-2
2.396E-1
1.000E0
 1 1
22 GO:0047021 15-hydroxyprostaglandin dehydrogenase (NADP+) activity 3.613E-3 3.841E-2
2.396E-1
1.000E0
 1 1
23 GO:0050221 prostaglandin-E2 9-reductase activity 3.613E-3 3.841E-2
2.396E-1
1.000E0
 1 1
24 GO:0035500 MH2 domain binding 3.613E-3 3.841E-2
2.396E-1
1.000E0
 1 1
25 GO:0035501 MH1 domain binding 3.613E-3 3.841E-2
2.396E-1
1.000E0
 1 1
26 GO:0036487 nitric-oxide synthase inhibitor activity 3.613E-3 3.841E-2
2.396E-1
1.000E0
 1 1
27 GO:0030504 inorganic diphosphate transmembrane transporter activity 3.613E-3 3.841E-2
2.396E-1
1.000E0
 1 1
28 GO:0061135 endopeptidase regulator activity 3.857E-3 3.927E-2
2.450E-1
1.000E0
 4 177
29 GO:0030414 peptidase inhibitor activity 4.094E-3 3.927E-2
2.450E-1
1.000E0
 4 180
30 GO:0004860 protein kinase inhibitor activity 4.105E-3 3.927E-2
2.450E-1
1.000E0
 3 89
31 GO:0019210 kinase inhibitor activity 4.369E-3 4.045E-2
2.523E-1
1.000E0
 3 91
32 GO:0005520 insulin-like growth factor binding 4.577E-3 4.105E-2
2.561E-1
1.000E0
 2 28
33 GO:0005516 calmodulin binding 5.049E-3 4.391E-2
2.740E-1
1.000E0
 4 191
Show 28 more annotations

2: GO: Biological Process [Display Chart] 2454 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030198 extracellular matrix organization 3.742E-10 4.753E-7 3.984E-6 9.182E-7 13 354
2 GO:0043062 extracellular structure organization 3.873E-10 4.753E-7 3.984E-6 9.505E-7 13 355
3 GO:0061041 regulation of wound healing 9.762E-6 3.375E-3 2.830E-2 2.396E-2 6 136
4 GO:1902532 negative regulation of intracellular signal transduction 1.070E-5 3.375E-3 2.830E-2 2.626E-2 10 494
5 GO:0050673 epithelial cell proliferation 1.185E-5 3.375E-3 2.830E-2 2.907E-2 9 394
6 GO:0090402 oncogene-induced cell senescence 1.291E-5 3.375E-3 2.830E-2 3.169E-2 2 2
7 GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress 1.291E-5 3.375E-3 2.830E-2 3.169E-2 2 2
8 GO:0001503 ossification 1.504E-5 3.375E-3 2.830E-2 3.690E-2 9 406
9 GO:0060840 artery development 1.854E-5 3.375E-3 2.830E-2 4.550E-2 5 90
10 GO:0035239 tube morphogenesis 1.858E-5 3.375E-3 2.830E-2 4.560E-2 9 417
11 GO:0032102 negative regulation of response to external stimulus 1.976E-5 3.375E-3 2.830E-2 4.849E-2 8 320
12 GO:1900116 extracellular negative regulation of signal transduction 2.001E-5 3.375E-3 2.830E-2 4.910E-2 3 15
13 GO:1900115 extracellular regulation of signal transduction 2.001E-5 3.375E-3 2.830E-2 4.910E-2 3 15
14 GO:1900046 regulation of hemostasis 2.063E-5 3.375E-3 2.830E-2
5.063E-2
 5 92
15 GO:0030193 regulation of blood coagulation 2.063E-5 3.375E-3 2.830E-2
5.063E-2
 5 92
16 GO:0072224 metanephric glomerulus development 2.456E-5 3.661E-3 3.069E-2
6.028E-2
 3 16
17 GO:0050818 regulation of coagulation 2.536E-5 3.661E-3 3.069E-2
6.223E-2
 5 96
18 GO:0030335 positive regulation of cell migration 3.151E-5 4.030E-3 3.378E-2
7.732E-2
 9 446
19 GO:0014911 positive regulation of smooth muscle cell migration 3.190E-5 4.030E-3 3.378E-2
7.828E-2
 4 50
20 GO:0007162 negative regulation of cell adhesion 3.653E-5 4.030E-3 3.378E-2
8.964E-2
 7 254
21 GO:0010616 negative regulation of cardiac muscle adaptation 3.864E-5 4.030E-3 3.378E-2
9.483E-2
 2 3
22 GO:0035986 senescence-associated heterochromatin focus assembly 3.864E-5 4.030E-3 3.378E-2
9.483E-2
 2 3
23 GO:0035583 sequestering of TGFbeta in extracellular matrix 3.864E-5 4.030E-3 3.378E-2
9.483E-2
 2 3
24 GO:2000147 positive regulation of cell motility 3.941E-5 4.030E-3 3.378E-2
9.671E-2
 9 459
25 GO:0051272 positive regulation of cellular component movement 4.814E-5 4.671E-3 3.916E-2
1.181E-1
 9 471
26 GO:0061298 retina vasculature development in camera-type eye 4.949E-5 4.671E-3 3.916E-2
1.214E-1
 3 20
27 GO:1903034 regulation of response to wounding 5.223E-5 4.728E-3 3.964E-2
1.282E-1
 9 476
28 GO:0040017 positive regulation of locomotion 5.395E-5 4.728E-3 3.964E-2
1.324E-1
 9 478
29 GO:0042063 gliogenesis 7.072E-5 5.985E-3
5.017E-2
1.736E-1
 7 282
30 GO:0061110 dense core granule biogenesis 7.711E-5 6.307E-3
5.287E-2
1.892E-1
 2 4
31 GO:0001654 eye development 8.442E-5 6.683E-3
5.602E-2
2.072E-1
 8 393
32 GO:0030206 chondroitin sulfate biosynthetic process 9.856E-5 7.558E-3
6.336E-2
2.419E-1
 3 25
33 GO:0038084 vascular endothelial growth factor signaling pathway 1.111E-4 7.983E-3
6.692E-2
2.727E-1
 3 26
34 GO:0010001 glial cell differentiation 1.207E-4 7.983E-3
6.692E-2
2.962E-1
 6 213
35 GO:0061440 kidney vasculature development 1.247E-4 7.983E-3
6.692E-2
3.060E-1
 3 27
36 GO:0061437 renal system vasculature development 1.247E-4 7.983E-3
6.692E-2
3.060E-1
 3 27
37 GO:2000987 positive regulation of behavioral fear response 1.282E-4 7.983E-3
6.692E-2
3.146E-1
 2 5
38 GO:1903242 regulation of cardiac muscle hypertrophy in response to stress 1.282E-4 7.983E-3
6.692E-2
3.146E-1
 2 5
39 GO:1903367 positive regulation of fear response 1.282E-4 7.983E-3
6.692E-2
3.146E-1
 2 5
40 GO:0051961 negative regulation of nervous system development 1.301E-4 7.983E-3
6.692E-2
3.193E-1
 7 311
41 GO:0014910 regulation of smooth muscle cell migration 1.342E-4 8.034E-3
6.735E-2
3.294E-1
 4 72
42 GO:0006809 nitric oxide biosynthetic process 1.573E-4 8.906E-3
7.466E-2
3.860E-1
 4 75
43 GO:0030111 regulation of Wnt signaling pathway 1.643E-4 8.906E-3
7.466E-2
4.033E-1
 7 323
44 GO:0050678 regulation of epithelial cell proliferation 1.739E-4 8.906E-3
7.466E-2
4.269E-1
 7 326
45 GO:0048562 embryonic organ morphogenesis 1.772E-4 8.906E-3
7.466E-2
4.350E-1
 7 327
46 GO:0014909 smooth muscle cell migration 1.831E-4 8.906E-3
7.466E-2
4.493E-1
 4 78
47 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 1.896E-4 8.906E-3
7.466E-2
4.654E-1
 3 31
48 GO:2000822 regulation of behavioral fear response 1.919E-4 8.906E-3
7.466E-2
4.708E-1
 2 6
49 GO:0071692 protein localization to extracellular region 1.919E-4 8.906E-3
7.466E-2
4.708E-1
 2 6
50 GO:1903365 regulation of fear response 1.919E-4 8.906E-3
7.466E-2
4.708E-1
 2 6
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 190 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031012 extracellular matrix 2.311E-13 4.391E-11 2.559E-10 4.391E-11 17 444
2 GO:0005578 proteinaceous extracellular matrix 6.327E-11 6.011E-9 3.502E-8 1.202E-8 14 379
3 GO:0044420 extracellular matrix component 4.482E-8 2.839E-6 1.654E-5 8.516E-6 8 143
4 GO:0001527 microfibril 5.258E-6 2.498E-4 1.455E-3 9.990E-4 3 10
5 GO:0005589 collagen type VI trimer 3.821E-5 1.210E-3 7.050E-3 7.260E-3 2 3
6 GO:0098647 collagen beaded filament 3.821E-5 1.210E-3 7.050E-3 7.260E-3 2 3
7 GO:0035985 senescence-associated heterochromatin focus 7.624E-5 1.843E-3 1.074E-2 1.449E-2 2 4
8 GO:0005925 focal adhesion 8.148E-5 1.843E-3 1.074E-2 1.548E-2 8 393
9 GO:0005924 cell-substrate adherens junction 8.896E-5 1.843E-3 1.074E-2 1.690E-2 8 398
10 GO:0030055 cell-substrate junction 9.700E-5 1.843E-3 1.074E-2 1.843E-2 8 403
11 GO:0005912 adherens junction 3.375E-4 5.829E-3 3.397E-2
6.412E-2
 8 484
12 GO:0031594 neuromuscular junction 1.383E-3 2.190E-2
1.276E-1
2.628E-1
 3 61
13 GO:0031091 platelet alpha granule 2.503E-3 3.659E-2
2.132E-1
4.756E-1
 3 75
14 GO:0098644 complex of collagen trimers 3.076E-3 4.174E-2
2.432E-1
5.844E-1
 2 23
15 GO:0097489 multivesicular body, internal vesicle lumen 3.599E-3 4.274E-2
2.490E-1
6.838E-1
 1 1
16 GO:0038045 large latent transforming growth factor-beta complex 3.599E-3 4.274E-2
2.490E-1
6.838E-1
 1 1
17 GO:0005581 collagen trimer 3.935E-3 4.398E-2
2.563E-1
7.476E-1
 3 88
Show 12 more annotations

4: Human Phenotype [Display Chart] 423 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0006384 Club-shaped distal femur 9.225E-5 1.951E-2
1.293E-1
 3.902E-2 2 3
2 HP:0004407 Bony paranasal bossing 9.225E-5 1.951E-2
1.293E-1
 3.902E-2 2 3
3 HP:0001742 Nasal obstruction {has synonym type="layperson"} 1.839E-4 2.592E-2
1.718E-1
7.777E-2
 2 4

5: Mouse Phenotype [Display Chart] 2083 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000130 abnormal trabecular bone morphology 6.153E-8 1.165E-4 9.577E-4 1.282E-4 12 286
2 MP:0000454 abnormal jaw morphology 1.546E-7 1.165E-4 9.577E-4 3.220E-4 14 446
3 MP:0011504 abnormal limb long bone morphology 1.823E-7 1.165E-4 9.577E-4 3.797E-4 14 452
4 MP:0000458 abnormal mandible morphology 2.237E-7 1.165E-4 9.577E-4 4.661E-4 10 205
5 MP:0002115 abnormal limb bone morphology 3.265E-7 1.360E-4 1.118E-3 6.801E-4 14 474
6 MP:0000272 abnormal aorta morphology 7.035E-7 2.442E-4 2.007E-3 1.465E-3 10 232
7 MP:0004686 decreased length of long bones 2.391E-6 6.269E-4 5.153E-3 4.980E-3 11 331
8 MP:0011655 abnormal systemic artery morphology 2.612E-6 6.269E-4 5.153E-3 5.440E-3 10 268
9 MP:0005503 abnormal tendon morphology 2.709E-6 6.269E-4 5.153E-3 5.642E-3 5 39
10 MP:0000556 abnormal hindlimb morphology 3.156E-6 6.467E-4 5.315E-3 6.575E-3 12 413
11 MP:0002113 abnormal skeleton development 3.415E-6 6.467E-4 5.315E-3 7.114E-3 13 494
12 MP:0008271 abnormal bone ossification 4.566E-6 7.926E-4 6.514E-3 9.511E-3 12 428
13 MP:0003797 abnormal compact bone morphology 5.619E-6 9.003E-4 7.399E-3 1.170E-2 8 171
14 MP:0003935 abnormal craniofacial development 9.242E-6 1.297E-3 1.066E-2 1.925E-2 11 381
15 MP:0011109 lethality throughout fetal growth and development, incomplete penetrance 9.337E-6 1.297E-3 1.066E-2 1.945E-2 9 243
16 MP:0003856 abnormal hindlimb stylopod morphology 1.420E-5 1.849E-3 1.520E-2 2.959E-2 8 194
17 MP:0010468 abnormal thoracic aorta morphology 1.550E-5 1.900E-3 1.561E-2 3.230E-2 7 141
18 MP:0004902 abnormal uterus size 2.137E-5 2.472E-3 2.032E-2 4.450E-2 6 99
19 MP:0000448 pointed snout 3.925E-5 4.303E-3 3.537E-2
8.175E-2
 3 12
20 MP:0005352 small cranium 4.140E-5 4.311E-3 3.544E-2
8.623E-2
 4 34
21 MP:0000572 abnormal autopod morphology 6.025E-5 5.976E-3 4.912E-2
1.255E-1
 10 384
22 MP:0002932 abnormal joint morphology 6.419E-5 6.077E-3 4.995E-2
1.337E-1
 9 310
23 MP:0011089 perinatal lethality, complete penetrance 7.088E-5 6.419E-3
5.276E-2
1.476E-1
 9 314
24 MP:0005504 abnormal ligament morphology 7.950E-5 6.900E-3
5.671E-2
1.656E-1
 4 40
25 MP:0004111 abnormal coronary artery morphology 8.772E-5 7.308E-3
6.007E-2
1.827E-1
 4 41
26 MP:0000074 abnormal neurocranium morphology 9.998E-5 7.612E-3
6.256E-2
2.083E-1
 8 255
27 MP:0002191 abnormal artery morphology 1.015E-4 7.612E-3
6.256E-2
2.115E-1
 11 494
28 MP:0000559 abnormal femur morphology 1.046E-4 7.612E-3
6.256E-2
2.180E-1
 7 190
29 MP:0002051 increased skin papilloma incidence 1.060E-4 7.612E-3
6.256E-2
2.208E-1
 4 43
30 MP:0006433 abnormal articular cartilage morphology 1.188E-4 7.757E-3
6.375E-2
2.476E-1
 3 17
31 MP:0006049 semilunar valve regurgitation 1.188E-4 7.757E-3
6.375E-2
2.476E-1
 3 17
32 MP:0001926 female infertility 1.192E-4 7.757E-3
6.375E-2
2.482E-1
 9 336
33 MP:0000443 abnormal snout morphology 1.271E-4 8.022E-3
6.593E-2
2.647E-1
 7 196
34 MP:0001120 abnormal uterus morphology 1.354E-4 8.295E-3
6.817E-2
2.820E-1
 7 198
35 MP:0001302 eyelids open at birth 1.408E-4 8.379E-3
6.886E-2
2.932E-1
 5 87
36 MP:0010031 abnormal cranium size 1.568E-4 9.071E-3
7.455E-2
3.265E-1
 5 89
37 MP:0008151 increased diameter of long bones 1.635E-4 9.207E-3
7.567E-2
3.407E-1
 4 48
38 MP:0004851 increased testis weight 1.680E-4 9.207E-3
7.567E-2
3.499E-1
 3 19
39 MP:0000550 abnormal forelimb morphology 1.731E-4 9.247E-3
7.600E-2
3.606E-1
 7 206
40 MP:0010472 abnormal ascending aorta and coronary artery attachment 1.971E-4 9.777E-3
8.035E-2
4.106E-1
 2 4
41 MP:0012009 early parturition 1.971E-4 9.777E-3
8.035E-2
4.106E-1
 2 4
42 MP:0002294 short gestation period 1.971E-4 9.777E-3
8.035E-2
4.106E-1
 2 4
43 MP:0001574 abnormal oxygen level 2.207E-4 1.058E-2
8.699E-2
4.598E-1
 8 286
44 MP:0003711 pathological neovascularization 2.239E-4 1.058E-2
8.699E-2
4.663E-1
 5 96
45 MP:0011481 anterior iris synechia 2.287E-4 1.058E-2
8.699E-2
4.763E-1
 3 21
46 MP:0000163 abnormal cartilage morphology 3.064E-4 1.377E-2
1.132E-1
6.381E-1
 9 381
47 MP:0000455 abnormal maxilla morphology 3.189E-4 1.377E-2
1.132E-1
6.642E-1
 6 161
48 MP:0000166 abnormal chondrocyte morphology 3.252E-4 1.377E-2
1.132E-1
6.774E-1
 5 104
49 MP:0010931 abnormal trabecular bone connectivity density 3.437E-4 1.377E-2
1.132E-1
7.159E-1
 3 24
50 MP:0006429 abnormal hyaline cartilage morphology 3.437E-4 1.377E-2
1.132E-1
7.159E-1
 3 24
Show 45 more annotations

6: Domain [Display Chart] 522 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR009030 Growth fac rcpt InterPro 1.697E-6 8.860E-4 6.056E-3 8.860E-4 7 156
2 IPR000716 Thyroglobulin 1 InterPro 3.133E-5 2.248E-3 1.536E-2 1.635E-2 3 17
3 PF00086 Thyroglobulin 1 Pfam 3.133E-5 2.248E-3 1.536E-2 1.635E-2 3 17
4 4.10.800.10 - Gene3D 3.133E-5 2.248E-3 1.536E-2 1.635E-2 3 17
5 PS00484 THYROGLOBULIN 1 1 PROSITE 3.133E-5 2.248E-3 1.536E-2 1.635E-2 3 17
6 PS51162 THYROGLOBULIN 1 2 PROSITE 3.133E-5 2.248E-3 1.536E-2 1.635E-2 3 17
7 SM00211 TY SMART 3.133E-5 2.248E-3 1.536E-2 1.635E-2 3 17
8 IPR016352 SLRP I decor/aspor/byglycan InterPro 4.001E-5 2.248E-3 1.536E-2 2.088E-2 2 3
9 IPR000116 HMGA InterPro 4.001E-5 2.248E-3 1.536E-2 2.088E-2 2 3
10 PF01462 LRRNT Pfam 4.306E-5 2.248E-3 1.536E-2 2.248E-2 4 53
11 PS00354 HMGI Y PROSITE 7.983E-5 3.788E-3 2.590E-2 4.167E-2 2 4
12 PF12662 cEGF Pfam 1.170E-4 4.697E-3 3.211E-2
6.107E-2
 3 26
13 IPR026823 cEGF InterPro 1.170E-4 4.697E-3 3.211E-2
6.107E-2
 3 26
14 IPR022321 IGFBP 1-6 chordata InterPro 1.986E-4 6.912E-3 4.725E-2
1.037E-1
 2 6
15 IPR009168 IGFBP1-6 InterPro 1.986E-4 6.912E-3 4.725E-2
1.037E-1
 2 6
16 PF00683 TB Pfam 2.774E-4 9.050E-3
6.187E-2
1.448E-1
 2 7
17 3.90.290.10 - Gene3D 3.690E-4 1.133E-2
7.745E-2
1.926E-1
 2 8
18 SM00013 LRRNT SMART 4.690E-4 1.176E-2
8.042E-2
2.448E-1
 4 98
19 IPR000372 LRRNT InterPro 4.690E-4 1.176E-2
8.042E-2
2.448E-1
 4 98
20 IPR017878 TB dom InterPro 4.733E-4 1.176E-2
8.042E-2
2.471E-1
 2 9
21 PS51364 TB PROSITE 4.733E-4 1.176E-2
8.042E-2
2.471E-1
 2 9
22 PF00431 CUB Pfam 7.802E-4 1.851E-2
1.266E-1
4.073E-1
 3 49
23 SM00042 CUB SMART 8.279E-4 1.874E-2
1.281E-1
4.321E-1
 3 50
24 PS00222 IGFBP N 1 PROSITE 8.615E-4 1.874E-2
1.281E-1
4.497E-1
 2 12
25 2.60.120.290 - Gene3D 9.286E-4 1.939E-2
1.325E-1
4.847E-1
 3 52
26 PS01180 CUB PROSITE 9.817E-4 1.971E-2
1.347E-1
5.124E-1
 3 53
27 IPR000859 CUB dom InterPro 1.213E-3 2.346E-2
1.604E-1
6.334E-1
 3 57
28 PF02178 AT hook Pfam 1.552E-3 2.497E-2
1.707E-1
8.099E-1
 2 16
29 SM00181 EGF SMART 1.774E-3 2.497E-2
1.707E-1
9.261E-1
 5 236
30 SM00121 IB SMART 1.969E-3 2.497E-2
1.707E-1
1.000E0
 2 18
31 4.10.410.10 - Gene3D 1.969E-3 2.497E-2
1.707E-1
1.000E0
 2 18
32 IPR020901 Prtase inh Kunz-CS InterPro 1.969E-3 2.497E-2
1.707E-1
1.000E0
 2 18
33 SM00131 KU SMART 1.969E-3 2.497E-2
1.707E-1
1.000E0
 2 18
34 PF00014 Kunitz BPTI Pfam 2.195E-3 2.497E-2
1.707E-1
1.000E0
 2 19
35 PS00280 BPTI KUNITZ 1 PROSITE 2.195E-3 2.497E-2
1.707E-1
1.000E0
 2 19
36 PS50279 BPTI KUNITZ 2 PROSITE 2.195E-3 2.497E-2
1.707E-1
1.000E0
 2 19
37 IPR000742 EGF-like dom InterPro 2.280E-3 2.497E-2
1.707E-1
1.000E0
 5 250
38 PF00219 IGFBP Pfam 2.433E-3 2.497E-2
1.707E-1
1.000E0
 2 20
39 PS51323 IGFBP N 2 PROSITE 2.433E-3 2.497E-2
1.707E-1
1.000E0
 2 20
40 IPR000867 IGFBP-like InterPro 2.433E-3 2.497E-2
1.707E-1
1.000E0
 2 20
41 PS00022 EGF 1 PROSITE 2.527E-3 2.497E-2
1.707E-1
1.000E0
 5 256
42 IPR018503 Tetraspanin CS InterPro 2.683E-3 2.497E-2
1.707E-1
1.000E0
 2 21
43 SM00406 IGv SMART 2.773E-3 2.497E-2
1.707E-1
1.000E0
 3 76
44 IPR013032 EGF-like CS InterPro 2.792E-3 2.497E-2
1.707E-1
1.000E0
 5 262
45 IPR002223 Kunitz BPTI InterPro 3.217E-3 2.497E-2
1.707E-1
1.000E0
 2 23
46 PS50234 VWFA PROSITE 3.439E-3 2.497E-2
1.707E-1
1.000E0
 3 82
47 PF13855 LRR 8 Pfam 3.652E-3 2.497E-2
1.707E-1
1.000E0
 4 171
48 SM00327 VWA SMART 3.681E-3 2.497E-2
1.707E-1
1.000E0
 3 84
49 IPR028870 PCOLCE InterPro 3.683E-3 2.497E-2
1.707E-1
1.000E0
 1 1
50 IPR022327 IGFBP-4 InterPro 3.683E-3 2.497E-2
1.707E-1
1.000E0
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 571 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5884 Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans MSigDB C2 BIOCARTA (v5.1) 1.893E-12 1.081E-9 7.486E-9 1.081E-9 15 275
2 M3008 Genes encoding structural ECM glycoproteins MSigDB C2 BIOCARTA (v5.1) 1.865E-9 5.323E-7 3.687E-6 1.065E-6 11 196
3 576262 Extracellular matrix organization BioSystems: REACTOME 3.448E-9 6.562E-7 4.544E-6 1.969E-6 12 264
4 M16973 CBL mediated ligand-induced downregulation of EGF receptors MSigDB C2 BIOCARTA (v5.1) 2.987E-5 4.264E-3 2.953E-2 1.705E-2 3 13
5 730310 Elastic fibre formation BioSystems: REACTOME 4.391E-5 5.014E-3 3.473E-2 2.507E-2 4 41
6 852705 MicroRNAs in cancer BioSystems: KEGG 8.155E-5 7.761E-3
5.375E-2
 4.656E-2 8 296
7 198759 Myometrial Relaxation and Contraction Pathways BioSystems: WikiPathways 9.845E-5 8.031E-3
5.562E-2
5.622E-2
 6 155
8 833812 ECM proteoglycans BioSystems: REACTOME 1.406E-4 1.004E-2
6.951E-2
8.030E-2
 4 55
9 739007 Spinal Cord Injury BioSystems: WikiPathways 2.015E-4 1.278E-2
8.854E-2
1.151E-1
 5 112
10 138008 a6b1 and a6b4 Integrin signaling BioSystems: Pathway Interaction Database 4.413E-4 2.390E-2
1.655E-1
2.520E-1
 3 31
11 83067 Focal adhesion BioSystems: KEGG 4.604E-4 2.390E-2
1.655E-1
2.629E-1
 6 206
12 672458 Signaling Pathways in Glioblastoma BioSystems: WikiPathways 5.963E-4 2.784E-2
1.928E-1
3.405E-1
 4 80
13 M5882 Genes encoding proteoglycans MSigDB C2 BIOCARTA (v5.1) 6.338E-4 2.784E-2
1.928E-1
3.619E-1
 3 35
14 645296 EGFR Transactivation by Gastrin BioSystems: REACTOME 8.147E-4 3.101E-2
2.148E-1
4.652E-1
 2 9
15 730308 Crosslinking of collagen fibrils BioSystems: REACTOME 8.147E-4 3.101E-2
2.148E-1
4.652E-1
 2 9
16 83072 Gap junction BioSystems: KEGG 8.914E-4 3.159E-2
2.188E-1
5.090E-1
 4 89
17 M5887 Genes encoding structural components of basement membranes MSigDB C2 BIOCARTA (v5.1) 9.406E-4 3.159E-2
2.188E-1
5.371E-1
 3 40
18 833810 Non-integrin membrane-ECM interactions BioSystems: REACTOME 1.085E-3 3.443E-2
2.385E-1
6.198E-1
 3 42
19 645310 Dermatan sulfate biosynthesis BioSystems: REACTOME 1.237E-3 3.718E-2
2.575E-1
7.063E-1
 2 11
20 PW:0000238 insulin-like growth factor signaling Pathway Ontology 1.480E-3 4.225E-2
2.926E-1
8.450E-1
 2 12
Show 15 more annotations

8: Pubmed [Display Chart] 18853 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20551380 Proteomics characterization of extracellular space components in the human aorta. Pubmed 1.183E-12 2.231E-8 2.325E-7 2.231E-8 8 101
2 19453261:gr High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. GeneRIF 9.925E-11 6.237E-7 6.500E-6 1.871E-6 10 383
3 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 9.925E-11 6.237E-7 6.500E-6 1.871E-6 10 383
4 22261194 Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Pubmed 3.135E-10 1.478E-6 1.540E-5 5.910E-6 6 64
5 10889043 Differential in vivo modifications of the HMGI(Y) nonhistone chromatin proteins modulate nucleosome and DNA interactions. Pubmed 2.255E-9 8.503E-6 8.861E-5 4.251E-5 3 3
6 21423176 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for Ã?-Pix in negative regulation of focal adhesion maturation. Pubmed 4.852E-9 1.525E-5 1.589E-4 9.148E-5 8 286
7 11723132 Molecular interactions of biglycan and decorin with elastic fiber components: biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein 1. Pubmed 9.011E-9 2.427E-5 2.529E-4 1.699E-4 3 4
8 23563607 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Pubmed 2.223E-8 5.238E-5 5.459E-4 4.190E-4 6 129
9 20881960 Hundreds of variants clustered in genomic loci and biological pathways affect human height. Pubmed 2.819E-7 3.226E-4 3.362E-3 5.315E-3 6 198
10 24769233 Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. Pubmed 6.312E-7 3.226E-4 3.362E-3 1.190E-2 4 50
11 16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Pubmed 1.291E-6 3.226E-4 3.362E-3 2.433E-2 6 257
12 23530587 Diagnostic value of HMGAs, p53 and Ã?-catenin in discriminating adenocarcinoma from adenoma or reactive atypia in ampulla and common bile duct biopsies. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
13 12666199:gr Differential expression of decorin and biglycan genes during palatogenesis in normal and retinoic acid-treated mice. GeneRIF 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
14 15994311:gr Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis. GeneRIF 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
15 26280531 Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
16 24675463 Temozolomide resistance in glioblastoma cells occurs partly through epidermal growth factor receptor-mediated induction of connexin 43. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
17 21739478 Downregulation of Mig-6 in nonsmall-cell lung cancer is associated with EGFR signaling. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
18 17311283 Tenascin cytotactin epidermal growth factor-like repeat binds epidermal growth factor receptor with low affinity. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
19 11406267 HMGI/Y proteins: flexible regulators of transcription and chromatin structure. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
20 17005673 Repression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcription. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
21 16938379 Lymphocytes from patients with early stage of B-cell chronic lymphocytic leukaemia and long survival synthesize decorin. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
22 18247373:gr The tetraspanin CD9 modulates epidermal growth factor receptor signaling in cancer cells. GeneRIF 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
23 24550449 A glioma classification scheme based on coexpression modules of EGFR and PDGFRA. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
24 20367117 Biglycan regulates the expression of EGF receptors through EGF signaling pathways in human articular chondrocytes. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
25 17188951:gr Impaired posterior frontal sutural fusion in the biglycan/decorin double deficient mice. GeneRIF 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
26 19609535:gr Gene expressions of HMGI-C and HMGI(Y) are associated with stage and metastasis in colorectal cancer. GeneRIF 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
27 18247373 The tetraspanin CD9 modulates epidermal growth factor receptor signaling in cancer cells. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
28 15556944 Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
29 15044481 Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
30 20004941 Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation, invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
31 22611165:gr Epidermal growth factor regulates connexin 43 in the human epididymis: role of gap junctions in azoospermia. GeneRIF 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
32 11470832 Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
33 22323597:gr Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response. GeneRIF 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
34 26676968 Pigment-Synthesizing Melanocytic Neoplasm With Protein Kinase C Alpha (PRKCA) Fusion. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
35 20351267:gr Mig-6 controls EGFR trafficking and suppresses gliomagenesis. GeneRIF 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
36 22613496:gr Expression levels of HMGA2 and CD9 and its clinicopathological significances in the benign and malignant lesions of the gallbladder. GeneRIF 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
37 17335953 Endocytosis of the dermatan sulfate proteoglycan decorin utilizes multiple pathways and is modulated by epidermal growth factor receptor signaling. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
38 24117774 Decorin and biglycan immunolocalization in non-villous structures of healthy and pathological human placentas. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
39 17935122:gr Detection of high-mobility group proteins A1 and A2 represents a valid diagnostic marker in post-pubertal testicular germ cell tumours. GeneRIF 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
40 16938379:gr Lymphocytes from patients with early stage of B-cell chronic lymphocytic leukaemia and long survival synthesize decorin. GeneRIF 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
41 2590169 Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
42 22316125 EGFR ligands drive multipotential stromal cells to produce multiple growth factors and cytokines via early growth response-1. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
43 1709161 Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
44 2647739 Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
45 17335953:gr Endocytosis of the dermatan sulfate proteoglycan decorin utilizes multiple pathways and is modulated by epidermal growth factor receptor signaling. GeneRIF 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
46 17599051 The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
47 22253749:gr Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition. GeneRIF 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
48 20367117:gr Biglycan regulates the expression of EGF receptors through EGF signaling pathways in human articular chondrocytes. GeneRIF 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
49 12105206:gr Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope. GeneRIF 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
50 25400079 Periostin suppression induces decorin secretion leading to reduced breast cancer cell motility and invasion. Pubmed 1.745E-6 3.226E-4 3.362E-3 3.290E-2 2 2
Show 45 more annotations

9: Interaction [Display Chart] 2458 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ELN ELN interactions 3.711E-10 9.122E-7 7.648E-6 9.122E-7 6 24
2 int:FBN1 FBN1 interactions 2.874E-7 3.532E-4 2.962E-3 7.064E-4 4 15
3 int:MFAP2 MFAP2 interactions 4.790E-6 3.924E-3 3.290E-2 1.177E-2 3 9
4 int:ANPEP ANPEP interactions 1.522E-5 9.352E-3
7.841E-2
 3.741E-2 2 2
5 int:FBN2 FBN2 interactions 2.551E-5 1.254E-2
1.052E-1
6.271E-2
 3 15
6 int:IGF1 IGF1 interactions 3.791E-5 1.553E-2
1.302E-1
9.319E-2
 3 17
7 int:COL4A3 COL4A3 interactions 7.332E-5 2.575E-2
2.159E-1
1.802E-1
 3 21
8 int:WISP1 WISP1 interactions 9.085E-5 2.791E-2
2.340E-1
2.233E-1
 2 4
9 int:TNF TNF interactions 1.080E-4 2.951E-2
2.474E-1
2.656E-1
 5 120
10 int:DPT DPT interactions 1.510E-4 3.543E-2
2.971E-1
3.712E-1
 2 5
11 int:MMP3 MMP3 interactions 1.586E-4 3.543E-2
2.971E-1
3.897E-1
 3 27
Show 6 more annotations

10: Cytoband [Display Chart] 67 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1q25.3-q31.1 1q25.3-q31.1 1.991E-3 1.905E-2
9.126E-2
1.334E-1
 1 1
2 10p15.3-p15.2 10p15.3-p15.2 1.991E-3 1.905E-2
9.126E-2
1.334E-1
 1 1
3 8p21-p12 8p21-p12 1.991E-3 1.905E-2
9.126E-2
1.334E-1
 1 1
4 6q21-q23.2 6q21-q23.2 1.991E-3 1.905E-2
9.126E-2
1.334E-1
 1 1
5 17q22-q23.2 17q22-q23.2 1.991E-3 1.905E-2
9.126E-2
1.334E-1
 1 1
6 11p14-p13 11p14-p13 1.991E-3 1.905E-2
9.126E-2
1.334E-1
 1 1
7 18q11-q12 18q11-q12 1.991E-3 1.905E-2
9.126E-2
1.334E-1
 1 1
8 7q22 7q22 2.760E-3 2.311E-2
1.107E-1
1.849E-1
 2 39
9 2p22.3-p21 2p22.3-p21 3.978E-3 2.423E-2
1.160E-1
2.665E-1
 1 2
10 12p12.3-p12.1 12p12.3-p12.1 3.978E-3 2.423E-2
1.160E-1
2.665E-1
 1 2
11 5q23-q31 5q23-q31 3.978E-3 2.423E-2
1.160E-1
2.665E-1
 1 2
12 17q12-q21.1 17q12-q21.1 5.960E-3 2.662E-2
1.275E-1
3.993E-1
 1 3
13 15q25-q26 15q25-q26 5.960E-3 2.662E-2
1.275E-1
3.993E-1
 1 3
14 3q21-q25 3q21-q25 5.960E-3 2.662E-2
1.275E-1
3.993E-1
 1 3
15 7p12 7p12 5.960E-3 2.662E-2
1.275E-1
3.993E-1
 1 3
16 8q23-q24 8q23-q24 7.939E-3 3.325E-2
1.592E-1
5.319E-1
 1 4
17 10p12 10p12 1.385E-2 4.885E-2
2.340E-1
9.282E-1
 1 7
18 6q14 6q14 1.385E-2 4.885E-2
2.340E-1
9.282E-1
 1 7
19 6q14-q15 6q14-q15 1.385E-2 4.885E-2
2.340E-1
9.282E-1
 1 7
Show 14 more annotations

11: Transcription Factor Binding Site [Display Chart] 371 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 48 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1065 Insulin like growth factor binding proteins genenames.org 1.059E-4 5.081E-3 2.265E-2 5.081E-3 2 6
2 511 Canonical high mobility group genenames.org 3.848E-4 7.375E-3 3.289E-2 1.847E-2 2 11
3 573 Small leucine rich repeat proteoglycans genenames.org 4.610E-4 7.375E-3 3.289E-2 2.213E-2 2 12
4 593 CD molecules|V-set domain containing|I-set domain containing|Sialic acid binding Ig like lectins genenames.org 9.180E-4 1.102E-2 4.912E-2 4.406E-2 4 161
5 768 CD molecules|Tetraspanins genenames.org 3.557E-3 3.415E-2
1.523E-1
1.707E-1
 2 33

13: Coexpression [Display Chart] 4954 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v5.1) 1.056E-21 5.232E-18 4.754E-17 5.232E-18 18 200
2 M13867 Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.797E-21 6.929E-18 6.295E-17 1.386E-17 19 256
3 M19541 Genes commonly down-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.819E-17 3.004E-14 2.729E-13 9.011E-14 19 408
4 M17471 Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS, non-invasive). MSigDB C2: CGP Curated Gene Sets (v5.1) 5.926E-16 7.339E-13 6.668E-12 2.936E-12 17 351
5 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.863E-15 2.836E-12 2.577E-11 1.418E-11 15 260
6 M13256 Genes down-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.687E-14 2.219E-11 2.016E-10 1.331E-10 13 190
7 M2572 Genes in the 'mesenchymal transition signature' common to all invasive cancer types. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.331E-13 3.065E-10 2.785E-9 2.146E-9 9 64
8 M9639 Genes up-regulated in MDA-MB-231 cells (breast cancer) after knockdown of SATB1 [GeneID=6304] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.275E-12 7.897E-10 7.174E-9 6.317E-9 15 395
9 M2128 Genes up-regulated in growing IMR90 cells (fibroblast) after knockdown of RB1 [GeneID=5925] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.361E-11 7.492E-9 6.807E-8 6.743E-8 12 243
10 M1804 Genes up-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.073E-11 3.504E-8 3.183E-7 3.504E-7 12 280
11 M6520 Genes up-regulated in patients at the incipient stage of Alzheimer's disease. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.373E-10 1.069E-7 9.708E-7 1.175E-6 13 390
12 M2573 Genes consistently up-regulated in mammary stem cells both in mouse and human species. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.265E-10 1.348E-7 1.225E-6 1.617E-6 14 489
13 M12602 Genes positively correlated with recurrence free survival in patients with hepatitis B-related (HBV) hepatocellular carcinoma (HCC). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.415E-9 5.391E-7 4.898E-6 7.009E-6 8 105
14 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.768E-9 6.255E-7 5.683E-6 8.757E-6 13 460
15 M12313 Genes up-regulated in MEWO cells (melanoma) after 96 h of methionine [PubChem=876] deprivation. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.359E-9 1.109E-6 1.008E-5 1.664E-5 8 117
16 M4680 Genes up-regulated in RD cells (embryonal rhabdomyosarcoma, ERMS) by expression of PAX3- or PAX7-FOXO1 [GeneID=5077;5081;2308] fusions off retroviral vectors. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.248E-9 2.221E-6 2.018E-5 3.591E-5 10 255
17 M15484 Genes changed in HMLE cells (mmortalized nontransformed mammary epithelium) after RNAi knockdown of both CDH1 and CTNNB1 [GeneID=999;1499], compared to the knockdown of CDH1 alone. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.826E-9 2.221E-6 2.018E-5 3.877E-5 7 83
18 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.070E-9 2.221E-6 2.018E-5 3.998E-5 12 425
19 M1610 All significantly up-regulated genes in kidney glomeruli isolated from TCF21 [Gene ID=6943] knockout mice. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.727E-9 2.275E-6 2.067E-5 4.323E-5 12 428
20 M19130 Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 16 h time point that were not down-regulated at the previous time point, 14 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.005E-8 2.490E-6 2.262E-5 4.980E-5 7 86
21 GSE28737 BCL6 HET VS BCL6 KO FOLLICULAR BCELL DN Genes down-regulated in follicular B lymphocytes with BCL6 [GeneID=604] knockout: heterozygotic versus homozygotic strains. MSigDB C7: Immunologic Signatures (v5.1) 1.320E-8 2.842E-6 2.582E-5 6.538E-5 9 200
22 M6480 Genes up-regulated in monocyte-derived dendritic cells: untreated versus LPS (3h). MSigDB C7: Immunologic Signatures (v5.1) 1.320E-8 2.842E-6 2.582E-5 6.538E-5 9 200
23 M5891 Genes up-regulated in response to low oxygen levels (hypoxia). MSigDB H: Hallmark Gene Sets (v5.1) 1.320E-8 2.842E-6 2.582E-5 6.538E-5 9 200
24 M4065 Down-regulated at 24 h following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v5.1) 1.496E-8 3.087E-6 2.805E-5 7.409E-5 7 91
25 M12225 Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.635E-8 3.240E-6 2.944E-5 8.100E-5 9 205
26 M5942 Genes down-regulated in response to ultraviolet (UV) radiation. MSigDB H: Hallmark Gene Sets (v5.1) 1.733E-8 3.301E-6 2.999E-5 8.583E-5 8 144
27 M14098 Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 24 h time point that were not down-regulated at the previous time point, 20 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.147E-8 3.940E-6 3.580E-5 1.064E-4 8 148
28 M1484 Genes up-regulated in pancreatic cells from mice with double knockout of E2F1 [GeneID=1869] and E2F2 [GeneID=1870] compared to wild type. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.512E-8 4.445E-6 4.039E-5 1.245E-4 8 151
29 M4491 Genes down-regulated in ANBL-6 cell line (multiple myeloma, MM) expressing an activated form of NRAS [GeneID=4893] off a plasmid vector compared to those co-cultured with bone marrow stromal cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.697E-8 4.607E-6 4.185E-5 1.336E-4 7 99
30 M8599 Genes up-regulated in NIH3T3 cells (fibroblasts) transformed by activated KRAS [GeneID=3845] vs those reverted to normal cells upon over-expression of a dominant negative form of CDC25 [GeneID=5923]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.812E-8 4.643E-6 4.219E-5 1.393E-4 6 58
31 M2256 Genes commonly down-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313 ,2078]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.943E-8 6.302E-6 5.725E-5 1.954E-4 9 227
32 M863 Myb-regulated genes in MCF7 (breast cancer) and lung epithelial cell lines overexpressing MYBL2, MYBL1 or MYB [GeneID=4605;4603;4602]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.848E-8 9.054E-6 8.226E-5 2.897E-4 10 318
33 M1124 Pubertal genes up-regulated by TGFB1 [GeneID=7040]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.037E-8 9.062E-6 8.233E-5 2.991E-4 8 169
34 M7363 Genes up-regulated in MCF7 cells (breast cancer) under hypoxia conditions. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.613E-8 9.635E-6 8.754E-5 3.276E-4 8 171
35 M2446 Genes down-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 10 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.324E-8 1.037E-5 9.418E-5 3.628E-4 9 244
36 M11788 Selected genes down-regulated during invasion of lymphatic vessels during metastasis. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.432E-8 1.298E-5 1.179E-4 4.673E-4 5 36
37 M12828 Genes up-regulated in reverted NIH3T3 cells (fibroblasts transformed by activated KRAS [GeneID=3845] which then reverted to normal cells upon stable over-expression of a dominant negative form of CDC25 [GeneID=5923]) vs normal fibroblasts. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.023E-7 1.369E-5 1.244E-4 5.067E-4 7 120
38 M2309 Genes up-regulated in RWPE-1 cells (prostate cancer) upon expression of constitutively active form of STAT3 [GeneID=6774]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.083E-7 1.412E-5 1.283E-4 5.365E-4 7 121
39 M5547 Age up-regulated genes in the human frontal cortex. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.343E-7 1.706E-5 1.550E-4 6.653E-4 9 262
40 M1320 Genes up-regulated in 10T1/2 cells (multipotent mesoderma) by expression of SHH [GeneID=6469]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.510E-7 1.870E-5 1.699E-4 7.480E-4 7 127
41 M14555 Down-regulated at any timepoint following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v5.1) 1.593E-7 1.905E-5 1.730E-4 7.893E-4 7 128
42 M2863 Genes up-regulated in epithelial lung cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v5.1) 1.615E-7 1.905E-5 1.730E-4 8.000E-4 8 192
43 M2698 Genes up-regulated in NCI-60 panel of cell lines with mutated TP53 [Gene ID=7157]. MSigDB C6: Oncogenic Signatures (v5.1) 1.748E-7 1.995E-5 1.812E-4 8.662E-4 8 194
44 M9197 Genes up-regulated in MCF7 cells (breast cancer) treated with hypoxia mimetic DMOG [PubChem=3080614]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.772E-7 1.995E-5 1.812E-4 8.777E-4 7 130
45 M6484 Genes up-regulated in monocyte-derived dendritic cells: untreated versus LPS and LPS like antigen from O. planktothrix (3h). MSigDB C7: Immunologic Signatures (v5.1) 2.125E-7 2.339E-5 2.125E-4 1.052E-3 8 199
46 M3429 Genes down-regulated in comparison of control CD4 [GeneID=920] CD8 thymocytes versus those after stimulation with anti-Vbeta5 antibodies. MSigDB C7: Immunologic Signatures (v5.1) 2.208E-7 2.377E-5 2.160E-4 1.094E-3 8 200
47 M9128 Genes up-regulated in UB27 cells (osteosarcoma) at any time point after inducing the expression of a mutant form of WT1 [GeneID=7490]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.698E-7 3.898E-5 3.541E-4 1.832E-3 8 214
48 M4995 Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.869E-7 3.993E-5 3.628E-4 1.917E-3 10 390
49 M19467 Genes down-regulated in five primary endothelial cell types (lung, aortic, iliac, dermal, and colon) by TNF [GeneID=7124]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.996E-7 4.040E-5 3.671E-4 1.980E-3 6 90
50 M8901 Down-regulated genes from the 324 genes identified by two analytical methods as changed in the mammary tumors induced by transgenic expression of ERBB2 [GeneID=2064]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.486E-7 4.444E-5 4.038E-4 2.222E-3 7 149
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2739 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 2.911E-29 7.972E-26 6.770E-25 7.972E-26 28 438
2 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 2.402E-27 3.289E-24 2.793E-23 6.578E-24 27 453
3 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 5.444E-27 4.970E-24 4.221E-23 1.491E-23 27 467
4 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 4.573E-26 3.131E-23 2.659E-22 1.252E-22 26 445
5 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 3.486E-20 1.808E-17 1.536E-16 9.547E-17 22 455
6 gudmap dev gonad e11.5 M GonadVasMes Flk k1 1000 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 4.496E-20 1.808E-17 1.536E-16 1.232E-16 20 338
7 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 4.621E-20 1.808E-17 1.536E-16 1.266E-16 22 461
8 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB 500 dev gonad e13.5 F VascAssocMesenchStromOvary MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.402E-19 4.800E-17 4.076E-16 3.840E-16 20 358
9 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.987E-19 9.089E-17 7.719E-16 8.180E-16 20 372
10 54Dn SubClass 54Dn 1SK Top 500 Cluster 2 54Dn SubClass 54Dn 1SK Top 500 Cluster 2 Brain Map - Allen iN 3.651E-19 1.000E-16 8.493E-16 1.000E-15 18 265
11 gudmap dev gonad e11.5 M GonadVasMes Flk 500 dev gonad e11.5 M GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.077E-18 7.155E-16 6.076E-15 8.428E-15 20 419
12 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB k3 500 dev gonad e13.5 F VascAssocMesenchStromOvary MafB k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.135E-18 7.155E-16 6.076E-15 8.586E-15 14 123
13 GSM777046 100 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 6.011E-18 1.266E-15 1.076E-14 1.646E-14 13 97
14 GSM777063 500 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.235E-17 2.416E-15 2.051E-14 3.382E-14 20 450
15 gudmap dev gonad e12.5 F VasAssMesen MafB k4 500 dev gonad e12.5 F VasAssMesen MafB k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.079E-17 7.449E-15 6.326E-14 1.117E-13 14 147
16 gudmap dev gonad e13.5 M InterstitTestis Sma 500 dev gonad e13.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 9.381E-17 1.606E-14 1.364E-13 2.569E-13 18 362
17 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma 500 dev gonad e13.5 F VascAssocMesenchStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.587E-16 2.557E-14 2.172E-13 4.348E-13 18 373
18 gudmap dev gonad e11.5 M GonadVasMes Flk k4 500 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.877E-16 2.856E-14 2.426E-13 5.141E-13 15 208
19 gudmap dev gonad e12.5 F VasAssocMesStromOvary Sma 500 dev gonad e12.5 F VasAssocMesStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.894E-16 4.171E-14 3.543E-13 7.926E-13 18 386
20 gudmap dev gonad e12.5 F VasAssMesen MafB 500 dev gonad e12.5 F VasAssMesen MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.313E-16 4.388E-14 3.726E-13 9.076E-13 18 389
21 GSM777043 100 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 3.364E-16 4.388E-14 3.726E-13 9.214E-13 12 97
22 JC fibro 1000 K1 JC fibro top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 4.129E-16 5.141E-14 4.366E-13 1.131E-12 19 464
23 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 8.298E-16 9.881E-14 8.392E-13 2.273E-12 18 410
24 PCBC ctl CardiacMyocyte 500 Progenitor-Cell-Biology-Consortium reference CardiacMyocyte top-relative-expression-ranked 500 PCBC 1.345E-15 1.535E-13 1.304E-12 3.684E-12 19 495
25 gudmap dev gonad e11.5 F GonadVasMes Flk 500 dev gonad e11.5 F GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.488E-15 1.631E-13 1.385E-12 4.076E-12 18 424
26 gudmap dev gonad e12.5 M InterstitLeydig MafB 500 dev gonad e12.5 M InterstitLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.128E-15 2.241E-13 1.903E-12 5.827E-12 17 364
27 GSM777059 500 Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 2.721E-15 2.760E-13 2.344E-12 7.452E-12 18 439
28 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k4 1000 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 5.527E-15 5.407E-13 4.592E-12 1.514E-11 15 261
29 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB k2 1000 dev gonad e13.5 F VascAssocMesenchStromOvary MafB k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 7.316E-15 6.909E-13 5.868E-12 2.004E-11 15 266
30 gudmap dev gonad e11.5 F GonMes Sma k4 1000 dev gonad e11.5 F GonMes Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 8.038E-15 7.339E-13 6.232E-12 2.202E-11 16 328
31 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 2.082E-14 1.840E-12 1.563E-11 5.704E-11 18 494
32 endothelial SubClass DCN-hi Top 500 All endothelial SubClass DCN-hi Top 500 All Brain Map - Barres 2.156E-14 1.845E-12 1.567E-11 5.905E-11 18 495
33 gudmap dev gonad e11.5 F GonadVasMes Flk k3 1000 dev gonad e11.5 F GonadVasMes Flk k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.748E-14 2.281E-12 1.937E-11 7.526E-11 16 355
34 gudmap dev gonad e13.5 M InterstitFLeydig MafB 500 dev gonad e13.5 M InterstitFLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.870E-14 2.312E-12 1.964E-11 7.862E-11 16 356
35 gudmap dev gonad e12.5 M InterstitTestis Sma 500 dev gonad e12.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.153E-14 4.815E-12 4.089E-11 1.685E-10 16 374
36 gudmap dev gonad e12.5 M InterstitLeydig MafB k1 1000 dev gonad e12.5 M InterstitLeydig MafB k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 7.251E-14 5.517E-12 4.685E-11 1.986E-10 15 311
37 gudmap dev gonad e11.5 M GonMes Sma k3 1000 dev gonad e11.5 M GonMes Sma k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 7.598E-14 5.625E-12 4.777E-11 2.081E-10 15 312
38 GSM777050 100 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 2.465E-13 1.777E-11 1.509E-10 6.751E-10 10 87
39 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 500 dev lower uro neuro e14.5 PelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.608E-12 1.130E-10 9.594E-10 4.406E-9 16 463
40 JC fibro 500 K3 JC fibro top-relative-expression-ranked 500 k-means-cluster#3 PCBC 3.153E-12 2.159E-10 1.833E-9 8.635E-9 12 206
41 gudmap dev gonad e13.5 M InterstitFLeydig MafB k3 1000 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.911E-12 2.613E-10 2.219E-9 1.071E-8 14 336
42 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 4.150E-12 2.707E-10 2.299E-9 1.137E-8 16 493
43 PCBC ctl BronchSmoothMuscl 500 Progenitor-Cell-Biology-Consortium reference BronchSmoothMuscl top-relative-expression-ranked 500 PCBC 4.279E-12 2.726E-10 2.315E-9 1.172E-8 16 494
44 gudmap dev gonad e12.5 M InterstitLeydig MafB k2 500 dev gonad e12.5 M InterstitLeydig MafB k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.278E-12 3.908E-10 3.319E-9 1.720E-8 11 165
45 GSM777067 100 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 8.875E-12 5.402E-10 4.588E-9 2.431E-8 9 85
46 GSM777055 100 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 9.887E-12 5.887E-10 5.000E-9 2.708E-8 9 86
47 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k2 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.163E-11 6.776E-10 5.755E-9 3.185E-8 10 127
48 gudmap kidney e15.5 Podocyte MafB k2 1000 kidney e15.5 Podocyte MafB k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.503E-11 8.576E-10 7.283E-9 4.116E-8 9 90
49 PCBC ctl CardiacMyocyte 100 Progenitor-Cell-Biology-Consortium reference CardiacMyocyte top-relative-expression-ranked 100 PCBC 3.599E-11 2.012E-9 1.708E-8 9.857E-8 9 99
50 gudmap dev gonad e13.5 M InterstitTestis Sma 200 dev gonad e13.5 M InterstitTestis Sma top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 5.364E-11 2.881E-9 2.447E-8 1.469E-7 10 148
Show 45 more annotations

15: Computational [Display Chart] 226 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 8.560E-13 1.934E-10 1.161E-9 1.934E-10 15 216
2 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 8.698E-10 9.665E-8 5.799E-7 1.966E-7 15 351
3 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 1.283E-9 9.665E-8 5.799E-7 2.899E-7 15 361
4 module 33 Genes in module 33 MSigDb: C4 - CM: Cancer Modules 1.801E-8 1.017E-6 6.104E-6 4.070E-6 14 372
5 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 5.980E-7 2.703E-5 1.622E-4 1.351E-4 13 419
6 module 122 Genes in module 122 MSigDb: C4 - CM: Cancer Modules 1.200E-6 4.447E-5 2.668E-4 2.711E-4 8 138
7 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 1.378E-6 4.447E-5 2.668E-4 3.113E-4 12 378
8 module 6 Genes in module 6 MSigDb: C4 - CM: Cancer Modules 2.986E-6 8.434E-5 5.060E-4 6.747E-4 12 407
9 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 4.450E-6 1.118E-4 6.705E-4 1.006E-3 12 423
10 module 105 Genes in module 105 MSigDb: C4 - CM: Cancer Modules 1.512E-5 3.418E-4 2.051E-3 3.418E-3 8 194
11 module 38 Genes in module 38 MSigDb: C4 - CM: Cancer Modules 5.242E-5 1.001E-3 6.008E-3 1.185E-2 11 455
12 module 3 Genes in module 3 MSigDb: C4 - CM: Cancer Modules 5.316E-5 1.001E-3 6.008E-3 1.202E-2 10 375
13 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 8.227E-5 1.430E-3 8.581E-3 1.859E-2 10 395
14 module 220 Genes in module 220 MSigDb: C4 - CM: Cancer Modules 1.060E-4 1.711E-3 1.026E-2 2.395E-2 9 328
15 module 24 Genes in module 24 MSigDb: C4 - CM: Cancer Modules 1.005E-3 1.514E-2
9.083E-2
2.271E-1
 9 445
16 module 19 Genes in module 19 MSigDb: C4 - CM: Cancer Modules 1.957E-3 2.764E-2
1.658E-1
4.422E-1
 7 307
17 module 190 Genes in module 190 MSigDb: C4 - CM: Cancer Modules 2.137E-3 2.841E-2
1.705E-1
4.830E-1
 2 12
18 module 121 Genes in module 121 MSigDb: C4 - CM: Cancer Modules 2.523E-3 3.168E-2
1.901E-1
5.702E-1
 4 98
19 module 474 Genes in module 474 MSigDb: C4 - CM: Cancer Modules 3.828E-3 4.553E-2
2.732E-1
8.651E-1
 2 16
Show 14 more annotations

16: MicroRNA [Display Chart] 1034 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CATTTCA,MIR-203:MSigDB CATTTCA,MIR-203:MSigDB MSigDB 3.638E-5 1.947E-2
1.464E-1
 3.761E-2 7 264
2 TACTTGA,MIR-26B:MSigDB TACTTGA,MIR-26B:MSigDB MSigDB 5.648E-5 1.947E-2
1.464E-1
5.840E-2
 7 283
3 TACTTGA,MIR-26A:MSigDB TACTTGA,MIR-26A:MSigDB MSigDB 5.648E-5 1.947E-2
1.464E-1
5.840E-2
 7 283
4 hsa-miR-211:PITA hsa-miR-211:PITA TOP PITA 1.218E-4 2.174E-2
1.634E-1
1.259E-1
 8 431
5 hsa-miR-204:PITA hsa-miR-204:PITA TOP PITA 1.218E-4 2.174E-2
1.634E-1
1.259E-1
 8 431
6 hsa-miR-500:PITA hsa-miR-500:PITA TOP PITA 1.339E-4 2.174E-2
1.634E-1
1.385E-1
 7 325
7 miR-203:PicTar miR-203:PicTar PicTar 1.472E-4 2.174E-2
1.634E-1
1.522E-1
 7 330
8 hsa-let-7a:miRTarbase hsa-let-7a:miRTarbase miRTarbase 2.037E-4 2.633E-2
1.980E-1
2.106E-1
 3 33
9 hsa-miR-34c-5p:PITA hsa-miR-34c-5p:PITA TOP PITA 5.607E-4 4.831E-2
3.632E-1
5.797E-1
 6 295
10 hsa-miR-449b:PITA hsa-miR-449b:PITA TOP PITA 5.607E-4 4.831E-2
3.632E-1
5.797E-1
 6 295
11 hsa-miR-449a:PITA hsa-miR-449a:PITA TOP PITA 5.607E-4 4.831E-2
3.632E-1
5.797E-1
 6 295
12 hsa-miR-34a:PITA hsa-miR-34a:PITA TOP PITA 5.607E-4 4.831E-2
3.632E-1
5.797E-1
 6 295
Show 7 more annotations

17: Drug [Display Chart] 17003 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000024766 chondroitin sulfate Stitch 2.082E-12 3.540E-8 3.652E-7 3.540E-8 15 413
2 D017258 Medroxyprogesterone Acetate CTD 1.446E-11 1.229E-7 1.268E-6 2.459E-7 14 390
3 D008769 Methylnitronitrosoguanidine CTD 3.036E-11 1.721E-7 1.775E-6 5.162E-7 12 263
4 C488369 dasatinib CTD 1.797E-10 6.457E-7 6.663E-6 3.055E-6 14 472
5 D000069439 Dasatinib CTD 1.899E-10 6.457E-7 6.663E-6 3.229E-6 14 474
6 MESH:D011471/D004958-M Prostatic Neoplasms affected by Estradiol CTD Marker 3.097E-10 8.776E-7 9.055E-6 5.266E-6 10 186
7 MESH:D011471/C017947-M Prostatic Neoplasms affected by sodium arsenite CTD Marker 4.020E-10 9.764E-7 1.007E-5 6.834E-6 9 136
8 MESH:D011471/D004054-T Prostatic Neoplasms affected by Diethylstilbestrol CTD Therapeutic 6.893E-10 1.465E-6 1.512E-5 1.172E-5 8 97
9 MESH:D011471/C006780-M Prostatic Neoplasms affected by bisphenol A CTD Marker 8.126E-10 1.535E-6 1.584E-5 1.382E-5 8 99
10 MESH:D011471/D001564-M Prostatic Neoplasms affected by Benzo(a)pyrene CTD Marker 1.021E-9 1.736E-6 1.791E-5 1.736E-5 9 151
11 CID000025435 desmosine Stitch 1.518E-8 2.346E-5 2.421E-4 2.581E-4 6 53
12 MESH:D011471/D004317-T Prostatic Neoplasms affected by Doxorubicin CTD Therapeutic 1.748E-8 2.477E-5 2.556E-4 2.972E-4 7 94
13 C031721 naphthalene CTD 3.829E-8 5.009E-5 5.168E-4 6.511E-4 11 396
14 D014639 Vanadium CTD 6.985E-8 8.484E-5 8.754E-4 1.188E-3 8 174
15 MESH:D011471/D019833-T Prostatic Neoplasms affected by Genistein CTD Therapeutic 7.544E-8 8.551E-5 8.824E-4 1.283E-3 7 116
16 CID000024759 hyaluronan Stitch 1.270E-7 1.350E-4 1.393E-3 2.160E-3 9 263
17 CID000063062 E)-4-hydroxytamoxifen Stitch 1.817E-7 1.817E-4 1.875E-3 3.089E-3 8 197
18 MESH:D011471/D013629-T Prostatic Neoplasms affected by Tamoxifen CTD Therapeutic 2.138E-7 2.019E-4 2.083E-3 3.634E-3 7 135
19 CID005280343 quercetin Stitch 2.767E-7 2.476E-4 2.555E-3 4.705E-3 11 482
20 CID000032756 dermatan sulfate Stitch 4.217E-7 3.430E-4 3.539E-3 7.170E-3 8 220
21 D004967 Estrogens CTD 4.236E-7 3.430E-4 3.539E-3 7.202E-3 10 398
22 D015073 2-Acetylaminofluorene CTD 4.747E-7 3.669E-4 3.786E-3 8.072E-3 10 403
23 CID000002224 arachidonic acid trifluoromethyl ketone Stitch 5.005E-7 3.680E-4 3.797E-3 8.510E-3 7 153
24 D001374 Azacitidine CTD 5.195E-7 3.680E-4 3.797E-3 8.833E-3 10 407
25 CID005288571 AC1NRBPT Stitch 7.361E-7 5.006E-4 5.166E-3 1.252E-2 7 162
26 D011433 Propranolol CTD 7.898E-7 5.165E-4 5.329E-3 1.343E-2 6 102
27 CID005393133 calcein blue Stitch 1.011E-6 6.269E-4 6.468E-3 1.718E-2 3 7
28 MESH:D011471/D017239-T Prostatic Neoplasms affected by Paclitaxel CTD Therapeutic 1.032E-6 6.269E-4 6.468E-3 1.755E-2 5 58
29 5987 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.144E-6 6.710E-4 6.924E-3 1.946E-2 7 173
30 4619 UP Ritodrine hydrochloride [23239-51-2]; Up 200; 12.4uM; PC3; HT HG-U133A Broad Institute CMAP 1.438E-6 8.148E-4 8.407E-3 2.444E-2 7 179
31 CID000000229 arabinopyranose Stitch 1.527E-6 8.227E-4 8.489E-3 2.596E-2 8 261
32 5822 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.548E-6 8.227E-4 8.489E-3 2.633E-2 7 181
33 D003345 Corticosterone CTD 1.616E-6 8.328E-4 8.593E-3 2.748E-2 8 263
34 CID000129920 JS-1 Stitch 1.684E-6 8.422E-4 8.690E-3 2.863E-2 4 28
35 C059765 amphotericin B, deoxycholate drug combination CTD 1.963E-6 9.536E-4 9.840E-3 3.338E-2 9 365
36 MESH:D008545/C017947-T Melanoma affected by sodium arsenite CTD Therapeutic 2.243E-6 1.060E-3 1.093E-2 3.815E-2 4 30
37 C583074 4,4'-hexafluorisopropylidene diphenol CTD 2.368E-6 1.088E-3 1.123E-2 4.026E-2 6 123
38 MESH:D008545/C014347-T Melanoma affected by decitabine CTD Therapeutic 2.570E-6 1.099E-3 1.134E-2 4.369E-2 4 31
39 2668 UP estradiol, USP; Up 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP 2.629E-6 1.099E-3 1.134E-2 4.471E-2 7 196
40 2798 UP Diflorasone Diacetate [33564-31-7]; Up 200; 8uM; MCF7; HT HG-U133A Broad Institute CMAP 2.720E-6 1.099E-3 1.134E-2 4.624E-2 7 197
41 2786 UP Corynanthine hydrochloride [66634-44-4]; Up 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP 2.720E-6 1.099E-3 1.134E-2 4.624E-2 7 197
42 MESH:D011471/D014810-T Prostatic Neoplasms affected by Vitamin E CTD Therapeutic 2.843E-6 1.099E-3 1.134E-2 4.833E-2 5 71
43 C010176 halofuginone CTD 2.852E-6 1.099E-3 1.134E-2 4.850E-2 6 127
44 3805 DN Fenbendazole [43210-67-9]; Down 200; 13.4uM; PC3; HT HG-U133A Broad Institute CMAP 2.908E-6 1.099E-3 1.134E-2 4.944E-2 7 199
45 6394 UP C75; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 2.908E-6 1.099E-3 1.134E-2 4.944E-2 7 199
46 C071834 glycidamide CTD 2.985E-6 1.103E-3 1.139E-2
5.076E-2
 6 128
47 CID000013811 isodesmosine Stitch 3.326E-6 1.203E-3 1.242E-2
5.656E-2
 4 33
48 MESH:D008545/C012589-T Melanoma affected by trichostatin A CTD Therapeutic 3.442E-6 1.219E-3 1.258E-2
5.852E-2
 3 10
49 CID000005360 suramin Stitch 3.894E-6 1.351E-3 1.394E-2
6.621E-2
 7 208
50 CID000073587 Iamin Stitch 4.236E-6 1.441E-3 1.486E-2
7.203E-2
 4 35
Show 45 more annotations

18: Disease [Display Chart] 1572 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0042025 Urinary Stress Incontinence DisGeNET BeFree 2.321E-7 3.648E-4 2.896E-3 3.648E-4 4 14
2 umls:C0023267 Fibroid Tumor DisGeNET Curated 2.086E-6 1.639E-3 1.301E-2 3.279E-3 9 287
3 umls:C0042133 Uterine Fibroids DisGeNET Curated 5.610E-6 2.637E-3 2.093E-2 8.819E-3 9 324
4 umls:C0598935 Tumor Initiation DisGeNET BeFree 8.251E-6 2.637E-3 2.093E-2 1.297E-2 7 182
5 umls:C0278488 Carcinoma breast stage IV DisGeNET BeFree 8.474E-6 2.637E-3 2.093E-2 1.332E-2 9 341
6 umls:C1519670 Tumor Angiogenesis DisGeNET BeFree 1.011E-5 2.637E-3 2.093E-2 1.590E-2 10 443
7 umls:C0162534 Prion Diseases DisGeNET Curated 1.174E-5 2.637E-3 2.093E-2 1.846E-2 5 74
8 umls:C1290854 Disorder of skull DisGeNET BeFree 1.595E-5 2.704E-3 2.146E-2 2.507E-2 2 2
9 umls:C1306242 Aggressive angiomyxoma DisGeNET BeFree 1.595E-5 2.704E-3 2.146E-2 2.507E-2 2 2
10 umls:C1512409 Hepatocarcinogenesis DisGeNET BeFree 1.720E-5 2.704E-3 2.146E-2 2.704E-2 10 471
11 umls:C0751690 Malignant Peripheral Nerve Sheath Tumor DisGeNET BeFree 3.171E-5 4.531E-3 3.597E-2 4.984E-2 6 151
12 umls:C0555198 Malignant Glioma DisGeNET BeFree 3.786E-5 4.705E-3 3.735E-2
5.952E-2
 9 412
13 umls:C0206754 Neuroendocrine Tumors DisGeNET Curated 4.291E-5 4.705E-3 3.735E-2
6.745E-2
 7 235
14 umls:C1708550 Intimal sarcoma DisGeNET BeFree 4.773E-5 4.705E-3 3.735E-2
7.503E-2
 2 3
15 umls:C0153567 Uterine Cancer DisGeNET BeFree 4.789E-5 4.705E-3 3.735E-2
7.528E-2
 4 50
16 umls:C0010701 Phyllodes Tumor DisGeNET Curated 4.789E-5 4.705E-3 3.735E-2
7.528E-2
 4 50
17 umls:C3840085 Disorder of Achilles tendon DisGeNET BeFree 5.758E-5 5.310E-3 4.215E-2
9.052E-2
 3 19
18 umls:C0750974 Brain Tumor, Primary DisGeNET BeFree 6.497E-5 5.310E-3 4.215E-2
1.021E-1
 4 54
19 umls:C0259785 Malignant Meningioma DisGeNET BeFree 6.755E-5 5.310E-3 4.215E-2
1.062E-1
 3 20
20 umls:C0812437 Oculo-dento-digital syndrome DisGeNET Curated 6.755E-5 5.310E-3 4.215E-2
1.062E-1
 3 20
21 umls:C0007115 Malignant neoplasm of thyroid DisGeNET BeFree 7.876E-5 5.896E-3 4.680E-2
1.238E-1
 9 453
22 umls:C0346202 Cervical Adenosquamous Carcinoma DisGeNET BeFree 9.521E-5 6.551E-3
5.200E-2
1.497E-1
 2 4
23 umls:C0032584 polyps DisGeNET Curated 9.585E-5 6.551E-3
5.200E-2
1.507E-1
 7 267
24 umls:C0006287 Bronchopulmonary Dysplasia DisGeNET Curated 1.170E-4 7.455E-3
5.918E-2
1.840E-1
 6 191
25 umls:C0334359 Papillary serous cystadenocarcinoma DisGeNET BeFree 1.186E-4 7.455E-3
5.918E-2
1.864E-1
 3 24
26 umls:C0154830 Proliferative diabetic retinopathy DisGeNET BeFree 1.428E-4 8.393E-3
6.662E-2
2.245E-1
 4 66
27 umls:C0025286 Meningioma DisGeNET Curated 1.442E-4 8.393E-3
6.662E-2
2.266E-1
 8 383
28 umls:C1852502 CRANIOMETAPHYSEAL DYSPLASIA, AUTOSOMAL DOMINANT DisGeNET Curated 1.699E-4 9.537E-3
7.570E-2
2.670E-1
 3 27
29 umls:C0003486 Aortic Aneurysm DisGeNET Curated 1.815E-4 9.840E-3
7.811E-2
2.854E-1
 6 207
30 umls:C0008479 Chondrosarcoma DisGeNET Curated 2.066E-4 1.032E-2
8.192E-2
3.248E-1
 6 212
31 umls:C0002940 Aneurysm DisGeNET Curated 2.093E-4 1.032E-2
8.192E-2
3.291E-1
 5 135
32 umls:C0751587 CADASIL Syndrome DisGeNET Curated 2.110E-4 1.032E-2
8.192E-2
3.317E-1
 3 29
33 umls:C0021841 Intestinal Neoplasms DisGeNET Curated 2.167E-4 1.032E-2
8.192E-2
3.406E-1
 5 136
34 umls:C0334579 Anaplastic astrocytoma DisGeNET Curated 2.242E-4 1.034E-2
8.207E-2
3.524E-1
 5 137
35 umls:C0281361 Adenocarcinoma of pancreas DisGeNET BeFree 2.361E-4 1.034E-2
8.207E-2
3.711E-1
 7 309
36 umls:C2981140 Glaucoma of childhood DisGeNET BeFree 2.368E-4 1.034E-2
8.207E-2
3.722E-1
 2 6
37 umls:C0040136 Thyroid Neoplasm DisGeNET Curated 2.504E-4 1.064E-2
8.444E-2
3.936E-1
 7 312
38 umls:C1800706 Idiopathic Pulmonary Fibrosis DisGeNET Curated 3.090E-4 1.246E-2
9.887E-2
4.857E-1
 7 323
39 umls:C0278688 Stage IV Ovarian Carcinoma DisGeNET BeFree 3.114E-4 1.246E-2
9.887E-2
4.896E-1
 3 33
40 umls:C0259783 mixed gliomas DisGeNET BeFree 3.306E-4 1.246E-2
9.887E-2
5.198E-1
 2 7
41 umls:C0278517 Non-small cell lung cancer recurrent DisGeNET BeFree 3.306E-4 1.246E-2
9.887E-2
5.198E-1
 2 7
42 umls:C0239946 Fibrosis, Liver DisGeNET BeFree 3.328E-4 1.246E-2
9.887E-2
5.232E-1
 7 327
43 umls:C0278883 Metastatic melanoma DisGeNET BeFree 3.713E-4 1.327E-2
1.053E-1
5.837E-1
 7 333
44 umls:C0007140 Carcinosarcoma DisGeNET Curated 3.715E-4 1.327E-2
1.053E-1
5.839E-1
 3 35
45 umls:C1654637 androgen independent prostate cancer DisGeNET BeFree 4.084E-4 1.427E-2
1.132E-1
6.420E-1
 5 156
46 umls:C0151650 Renal fibrosis DisGeNET BeFree 4.205E-4 1.437E-2
1.141E-1
6.611E-1
 5 157
47 umls:C0007112 Adenocarcinoma of prostate DisGeNET BeFree 4.456E-4 1.490E-2
1.183E-1
7.005E-1
 5 159
48 umls:C3539878 Triple Negative Breast Neoplasms DisGeNET BeFree 4.678E-4 1.532E-2
1.216E-1
7.353E-1
 8 456
49 umls:C0020542 Pulmonary Hypertension DisGeNET Curated 4.988E-4 1.600E-2
1.270E-1
7.841E-1
 6 250
50 umls:C0410787 Hereditary Connective Tissue Disorder DisGeNET BeFree 5.639E-4 1.764E-2
1.400E-1
8.864E-1
 2 9
Show 45 more annotations