Toppgene analysis for aggregated_1964_log, IC7, positive side

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1: GO: Molecular Function [Display Chart] 624 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004812 aminoacyl-tRNA ligase activity 3.062E-12 6.369E-10 4.467E-9 1.911E-9 10 44
2 GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds 3.062E-12 6.369E-10 4.467E-9 1.911E-9 10 44
3 GO:0016875 ligase activity, forming carbon-oxygen bonds 3.062E-12 6.369E-10 4.467E-9 1.911E-9 10 44
4 GO:0015175 neutral amino acid transmembrane transporter activity 1.043E-8 1.627E-6 1.141E-5 6.507E-6 7 33
5 GO:0016874 ligase activity 1.809E-8 2.257E-6 1.583E-5 1.129E-5 18 415
6 GO:0030170 pyridoxal phosphate binding 3.719E-7 3.300E-5 2.315E-4 2.320E-4 7 54
7 GO:0015171 amino acid transmembrane transporter activity 4.144E-7 3.300E-5 2.315E-4 2.586E-4 8 80
8 GO:0015179 L-amino acid transmembrane transporter activity 4.231E-7 3.300E-5 2.315E-4 2.640E-4 7 55
9 GO:0015186 L-glutamine transmembrane transporter activity 6.069E-6 4.208E-4 2.952E-3 3.787E-3 3 5
10 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1.810E-5 1.129E-3 7.920E-3 1.129E-2 4 19
11 GO:0046943 carboxylic acid transmembrane transporter activity 2.913E-5 1.653E-3 1.159E-2 1.818E-2 8 141
12 GO:0005342 organic acid transmembrane transporter activity 3.389E-5 1.762E-3 1.236E-2 2.115E-2 8 144
13 GO:0008483 transaminase activity 4.025E-5 1.932E-3 1.355E-2 2.512E-2 4 23
14 GO:0016769 transferase activity, transferring nitrogenous groups 5.674E-5 2.521E-3 1.768E-2 3.541E-2 4 25
15 GO:0000049 tRNA binding 6.059E-5 2.521E-3 1.768E-2 3.781E-2 5 49
16 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1.189E-4 4.637E-3 3.253E-2
7.419E-2
 4 30
17 GO:0048037 cofactor binding 1.441E-4 5.290E-3 3.711E-2
8.994E-2
 10 278
18 GO:0008514 organic anion transmembrane transporter activity 1.817E-4 6.300E-3 4.419E-2
1.134E-1
 8 183
19 GO:0038064 collagen receptor activity 4.315E-4 1.171E-2
8.212E-2
2.693E-1
 2 4
20 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity 4.315E-4 1.171E-2
8.212E-2
2.693E-1
 2 4
21 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity 4.315E-4 1.171E-2
8.212E-2
2.693E-1
 2 4
22 GO:0004329 formate-tetrahydrofolate ligase activity 4.315E-4 1.171E-2
8.212E-2
2.693E-1
 2 4
23 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity 4.315E-4 1.171E-2
8.212E-2
2.693E-1
 2 4
24 GO:0005112 Notch binding 6.295E-4 1.637E-2
1.148E-1
3.928E-1
 3 20
25 GO:0051087 chaperone binding 6.913E-4 1.716E-2
1.204E-1
4.313E-1
 5 82
26 GO:0098639 collagen binding involved in cell-matrix adhesion 7.152E-4 1.716E-2
1.204E-1
4.463E-1
 2 5
27 GO:0016830 carbon-carbon lyase activity 9.431E-4 2.180E-2
1.529E-1
5.885E-1
 4 51
28 GO:0015291 secondary active transmembrane transporter activity 9.848E-4 2.195E-2
1.539E-1
6.145E-1
 8 236
29 GO:0008509 anion transmembrane transporter activity 1.061E-3 2.219E-2
1.556E-1
6.620E-1
 9 297
30 GO:0098634 protein binding involved in cell-matrix adhesion 1.067E-3 2.219E-2
1.556E-1
6.657E-1
 2 6
31 GO:0016829 lyase activity 1.467E-3 2.808E-2
1.970E-1
9.157E-1
 7 195
32 GO:0046977 TAP binding 1.485E-3 2.808E-2
1.970E-1
9.267E-1
 2 7
33 GO:0000099 sulfur amino acid transmembrane transporter activity 1.485E-3 2.808E-2
1.970E-1
9.267E-1
 2 7
34 GO:0016742 hydroxymethyl-, formyl- and related transferase activity 1.969E-3 3.614E-2
2.535E-1
1.000E0
 2 8
35 GO:0016832 aldehyde-lyase activity 2.517E-3 4.172E-2
2.926E-1
1.000E0
 2 9
36 GO:0022889 serine transmembrane transporter activity 2.517E-3 4.172E-2
2.926E-1
1.000E0
 2 9
37 GO:0015194 L-serine transmembrane transporter activity 2.517E-3 4.172E-2
2.926E-1
1.000E0
 2 9
38 GO:0042605 peptide antigen binding 2.541E-3 4.172E-2
2.926E-1
1.000E0
 3 32
39 GO:0008083 growth factor activity 3.079E-3 4.927E-2
3.456E-1
1.000E0
 6 166
Show 34 more annotations

2: GO: Biological Process [Display Chart] 3140 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006520 cellular amino acid metabolic process 9.322E-18 2.927E-14 2.526E-13 2.927E-14 28 403
2 GO:0006418 tRNA aminoacylation for protein translation 9.950E-12 1.562E-8 1.348E-7 3.124E-8 10 49
3 GO:0043039 tRNA aminoacylation 1.874E-11 1.800E-8 1.553E-7 5.884E-8 10 52
4 GO:0043038 amino acid activation 2.293E-11 1.800E-8 1.553E-7 7.199E-8 10 53
5 GO:0008652 cellular amino acid biosynthetic process 3.952E-11 2.482E-8 2.141E-7 1.241E-7 12 97
6 GO:1901605 alpha-amino acid metabolic process 4.909E-11 2.569E-8 2.217E-7 1.541E-7 17 249
7 GO:1901607 alpha-amino acid biosynthetic process 1.077E-10 4.832E-8 4.170E-7 3.383E-7 11 82
8 GO:0009069 serine family amino acid metabolic process 4.026E-9 1.442E-6 1.244E-5 1.264E-5 8 45
9 GO:0009070 serine family amino acid biosynthetic process 4.132E-9 1.442E-6 1.244E-5 1.298E-5 6 17
10 GO:0006564 L-serine biosynthetic process 5.199E-9 1.520E-6 1.312E-5 1.632E-5 4 4
11 GO:0006563 L-serine metabolic process 5.326E-9 1.520E-6 1.312E-5 1.672E-5 5 9
12 GO:0046394 carboxylic acid biosynthetic process 9.129E-8 2.205E-5 1.903E-4 2.866E-4 15 315
13 GO:0016053 organic acid biosynthetic process 9.129E-8 2.205E-5 1.903E-4 2.866E-4 15 315
14 GO:0006399 tRNA metabolic process 4.415E-7 9.903E-5 8.546E-4 1.386E-3 11 180
15 GO:0034976 response to endoplasmic reticulum stress 4.875E-7 1.020E-4 8.805E-4 1.531E-3 13 265
16 GO:0035966 response to topologically incorrect protein 5.498E-7 1.050E-4 9.060E-4 1.726E-3 11 184
17 GO:0015804 neutral amino acid transport 5.684E-7 1.050E-4 9.060E-4 1.785E-3 6 36
18 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 1.229E-6 2.144E-4 1.850E-3 3.858E-3 7 64
19 GO:0030968 endoplasmic reticulum unfolded protein response 1.812E-6 2.926E-4 2.525E-3 5.691E-3 9 130
20 GO:0003333 amino acid transmembrane transport 1.863E-6 2.926E-4 2.525E-3 5.851E-3 7 68
21 GO:0015807 L-amino acid transport 2.059E-6 3.079E-4 2.657E-3 6.465E-3 7 69
22 GO:0034620 cellular response to unfolded protein 2.192E-6 3.128E-4 2.699E-3 6.882E-3 9 133
23 GO:0006986 response to unfolded protein 2.610E-6 3.564E-4 3.075E-3 8.197E-3 10 174
24 GO:0035967 cellular response to topologically incorrect protein 3.554E-6 4.650E-4 4.013E-3 1.116E-2 9 141
25 GO:0006868 glutamine transport 1.213E-5 1.523E-3 1.314E-2 3.808E-2 3 6
26 GO:0046655 folic acid metabolic process 1.448E-5 1.749E-3 1.509E-2 4.548E-2 4 18
27 GO:0043200 response to amino acid 1.550E-5 1.802E-3 1.555E-2 4.866E-2 8 129
28 GO:0036499 PERK-mediated unfolded protein response 2.263E-5 2.538E-3 2.190E-2
7.105E-2
 4 20
29 GO:0006979 response to oxidative stress 2.680E-5 2.902E-3 2.504E-2
8.416E-2
 14 440
30 GO:0006984 ER-nucleus signaling pathway 3.215E-5 3.306E-3 2.853E-2
1.010E-1
 5 43
31 GO:0009064 glutamine family amino acid metabolic process 3.264E-5 3.306E-3 2.853E-2
1.025E-1
 6 71
32 GO:0046653 tetrahydrofolate metabolic process 4.054E-5 3.978E-3 3.432E-2
1.273E-1
 4 23
33 GO:0043648 dicarboxylic acid metabolic process 4.528E-5 4.182E-3 3.609E-2
1.422E-1
 7 110
34 GO:1905039 carboxylic acid transmembrane transport 4.528E-5 4.182E-3 3.609E-2
1.422E-1
 7 110
35 GO:1903825 organic acid transmembrane transport 5.379E-5 4.751E-3 4.099E-2
1.689E-1
 7 113
36 GO:0030198 extracellular matrix organization 5.611E-5 4.751E-3 4.099E-2
1.762E-1
 12 354
37 GO:0006541 glutamine metabolic process 5.714E-5 4.751E-3 4.099E-2
1.794E-1
 4 25
38 GO:0043062 extracellular structure organization 5.765E-5 4.751E-3 4.099E-2
1.810E-1
 12 355
39 GO:0097193 intrinsic apoptotic signaling pathway 5.900E-5 4.751E-3 4.099E-2
1.853E-1
 11 301
40 GO:0038065 collagen-activated signaling pathway 7.095E-5 5.569E-3 4.806E-2
2.228E-1
 3 10
41 GO:0072593 reactive oxygen species metabolic process 9.281E-5 7.108E-3
6.134E-2
2.914E-1
 10 263
42 GO:0006865 amino acid transport 9.780E-5 7.312E-3
6.310E-2
3.071E-1
 8 167
43 GO:0006767 water-soluble vitamin metabolic process 1.096E-4 8.002E-3
6.905E-2
3.441E-1
 6 88
44 GO:1902475 L-alpha-amino acid transmembrane transport 1.550E-4 1.036E-2
8.937E-2
4.868E-1
 4 32
45 GO:0006760 folic acid-containing compound metabolic process 1.550E-4 1.036E-2
8.937E-2
4.868E-1
 4 32
46 GO:0042149 cellular response to glucose starvation 1.550E-4 1.036E-2
8.937E-2
4.868E-1
 4 32
47 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1.550E-4 1.036E-2
8.937E-2
4.868E-1
 4 32
48 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 1.659E-4 1.038E-2
8.956E-2
5.210E-1
 3 13
49 GO:0006094 gluconeogenesis 1.673E-4 1.038E-2
8.956E-2
5.253E-1
 6 95
50 GO:0007229 integrin-mediated signaling pathway 1.673E-4 1.038E-2
8.956E-2
5.253E-1
 6 95
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 300 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1990037 Lewy body core 7.273E-5 1.091E-2
6.854E-2
 2.182E-2 2 2
2 GO:1990617 CHOP-ATF4 complex 7.273E-5 1.091E-2
6.854E-2
 2.182E-2 2 2

4: Human Phenotype [Display Chart] 568 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0012122 Anterior uveitis 8.856E-5 2.515E-2
1.741E-1
5.030E-2
 2 2
2 HP:0100686 Enthesitis 8.856E-5 2.515E-2
1.741E-1
5.030E-2
 2 2

5: Mouse Phenotype [Display Chart] 2466 annotations before applied cutoff / 9299 genes in category

No results to display

6: Domain [Display Chart] 1093 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR001412 aa-tRNA-synth I CS InterPro 3.665E-7 2.699E-4 2.045E-3 4.006E-4 5 18
2 PS00178 AA TRNA LIGASE I PROSITE 4.939E-7 2.699E-4 2.045E-3 5.399E-4 5 19
3 3.40.640.10 - Gene3D 1.188E-6 2.885E-4 2.185E-3 1.299E-3 6 40
4 IPR015424 PyrdxlP-dep Trfase InterPro 1.601E-6 2.885E-4 2.185E-3 1.750E-3 6 42
5 IPR015421 PyrdxlP-dep Trfase major sub1 InterPro 1.601E-6 2.885E-4 2.185E-3 1.750E-3 6 42
6 3.40.50.620 - Gene3D 1.847E-6 2.885E-4 2.185E-3 2.019E-3 6 43
7 IPR014729 Rossmann-like a/b/a fold InterPro 1.847E-6 2.885E-4 2.185E-3 2.019E-3 6 43
8 SM00338 BRLZ SMART 5.783E-6 4.718E-4 3.574E-3 6.321E-3 6 52
9 PS51185 WHEP TRS 2 PROSITE 6.383E-6 4.718E-4 3.574E-3 6.977E-3 3 5
10 PS00762 WHEP TRS 1 PROSITE 6.383E-6 4.718E-4 3.574E-3 6.977E-3 3 5
11 IPR000738 WHEP-TRS dom InterPro 6.383E-6 4.718E-4 3.574E-3 6.977E-3 3 5
12 PF00458 WHEP-TRS Pfam 6.383E-6 4.718E-4 3.574E-3 6.977E-3 3 5
13 SM00991 WHEP-TRS SMART 6.383E-6 4.718E-4 3.574E-3 6.977E-3 3 5
14 PS00036 BZIP BASIC PROSITE 6.475E-6 4.718E-4 3.574E-3 7.077E-3 6 53
15 PS50217 BZIP PROSITE 6.475E-6 4.718E-4 3.574E-3 7.077E-3 6 53
16 IPR004827 bZIP InterPro 7.232E-6 4.940E-4 3.742E-3 7.905E-3 6 54
17 1.10.287.10 - Gene3D 1.269E-5 8.156E-4 6.178E-3 1.386E-2 3 6
18 PS50862 AA TRNA LIGASE II PROSITE 1.536E-5 8.839E-4 6.695E-3 1.679E-2 4 18
19 IPR006195 aa-tRNA-synth II InterPro 1.536E-5 8.839E-4 6.695E-3 1.679E-2 4 18
20 IPR009068 S15 NS1 RNA-bd InterPro 3.507E-5 1.916E-3 1.451E-2 3.833E-2 3 8
21 IPR002314 aa-tRNA-synt IIb InterPro 1.013E-4 5.035E-3 3.814E-2
1.108E-1
 3 11
22 PF00587 tRNA-synt 2b Pfam 1.013E-4 5.035E-3 3.814E-2
1.108E-1
 3 11
23 IPR002293 AA/rel permease1 InterPro 1.734E-4 7.899E-3
5.983E-2
1.896E-1
 3 13
24 PF13520 AA permease 2 Pfam 1.734E-4 7.899E-3
5.983E-2
1.896E-1
 3 13
25 IPR004760 L AA transporter InterPro 2.244E-4 9.811E-3
7.431E-2
2.453E-1
 2 3
26 3.90.1150.10 - Gene3D 2.618E-4 1.101E-2
8.336E-2
2.862E-1
 4 36
27 IPR009080 tRNAsynth Ia anticodon-bd InterPro 2.724E-4 1.103E-2
8.353E-2
2.977E-1
 3 15
28 IPR015422 PyrdxlP-dep Trfase major sub2 InterPro 2.916E-4 1.138E-2
8.621E-2
3.187E-1
 4 37
29 PF07716 bZIP 2 Pfam 4.019E-4 1.278E-2
9.677E-2
4.393E-1
 3 17
30 PF02882 THF DHG CYH C Pfam 4.463E-4 1.278E-2
9.677E-2
4.878E-1
 2 4
31 PF00579 tRNA-synt 1b Pfam 4.463E-4 1.278E-2
9.677E-2
4.878E-1
 2 4
32 IPR020631 THF DH/CycHdrlase NAD-bd dom InterPro 4.463E-4 1.278E-2
9.677E-2
4.878E-1
 2 4
33 IPR002305 aa-tRNA-synth Ic InterPro 4.463E-4 1.278E-2
9.677E-2
4.878E-1
 2 4
34 PF00763 THF DHG CYH Pfam 4.463E-4 1.278E-2
9.677E-2
4.878E-1
 2 4
35 IPR000672 THF DH/CycHdrlase InterPro 4.463E-4 1.278E-2
9.677E-2
4.878E-1
 2 4
36 IPR020630 THF DH/CycHdrlase cat dom InterPro 4.463E-4 1.278E-2
9.677E-2
4.878E-1
 2 4
37 IPR001007 VWF dom InterPro 4.777E-4 1.278E-2
9.677E-2
5.222E-1
 4 42
38 PF08441 Integrin alpha2 Pfam 4.793E-4 1.278E-2
9.677E-2
5.238E-1
 3 18
39 IPR013649 Integrin alpha-2 InterPro 4.793E-4 1.278E-2
9.677E-2
5.238E-1
 3 18
40 PS00242 INTEGRIN ALPHA PROSITE 4.793E-4 1.278E-2
9.677E-2
5.238E-1
 3 18
41 IPR000413 Integrin alpha InterPro 4.793E-4 1.278E-2
9.677E-2
5.238E-1
 3 18
42 SM00191 Int alpha SMART 5.655E-4 1.437E-2
1.089E-1
6.181E-1
 3 19
43 IPR013519 Int alpha beta-p InterPro 5.655E-4 1.437E-2
1.089E-1
6.181E-1
 3 19
44 IPR017932 GATase 2 dom InterPro 7.395E-4 1.796E-2
1.360E-1
8.083E-1
 2 5
45 PS51278 GATASE TYPE 2 PROSITE 7.395E-4 1.796E-2
1.360E-1
8.083E-1
 2 5
46 PS51470 FG GAP PROSITE 8.817E-4 2.008E-2
1.521E-1
9.637E-1
 3 22
47 IPR004841 AA-permease/SLC12A dom InterPro 8.817E-4 2.008E-2
1.521E-1
9.637E-1
 3 22
48 PF00324 AA permease Pfam 8.817E-4 2.008E-2
1.521E-1
9.637E-1
 3 22
49 PF06623 MHC I C Pfam 1.103E-3 2.405E-2
1.821E-1
1.000E0
 2 6
50 IPR010579 MHC I a C InterPro 1.103E-3 2.405E-2
1.821E-1
1.000E0
 2 6
Show 45 more annotations

7: Pathway [Display Chart] 851 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 105981 Cytosolic tRNA aminoacylation BioSystems: REACTOME 3.035E-14 2.583E-11 1.892E-10 2.583E-11 10 24
2 MAP00970 Aminoacyl tRNA biosynthesis MAP00970 Aminoacyl tRNA biosynthesis GenMAPP 7.742E-14 3.294E-11 2.413E-10 6.589E-11 9 18
3 105980 tRNA Aminoacylation BioSystems: REACTOME 1.929E-11 5.472E-9 4.008E-8 1.642E-8 10 42
4 106173 Amino acid synthesis and interconversion (transamination) BioSystems: REACTOME 2.888E-10 6.144E-8 4.500E-7 2.458E-7 7 17
5 920958 Trans-sulfuration and one carbon metabolism BioSystems: WikiPathways 1.076E-9 1.832E-7 1.342E-6 9.161E-7 8 31
6 83030 Aminoacyl-tRNA biosynthesis BioSystems: KEGG 2.217E-9 3.145E-7 2.303E-6 1.887E-6 10 66
7 SMP00004 Glycine, Serine and Threonine Metabolism SMPDB 6.637E-9 8.069E-7 5.910E-6 5.648E-6 7 25
8 106170 Amino acid transport across the plasma membrane BioSystems: REACTOME 3.438E-8 3.657E-6 2.679E-5 2.926E-5 7 31
9 P02776 Serine glycine biosynthesis PantherDB 6.887E-8 6.512E-6 4.770E-5 5.861E-5 4 5
10 790012 Biosynthesis of amino acids BioSystems: KEGG 9.322E-8 7.933E-6 5.810E-5 7.933E-5 9 73
11 530752 Serine biosynthesis BioSystems: REACTOME 1.296E-6 1.002E-4 7.342E-4 1.103E-3 3 3
12 82949 Glycine, serine and threonine metabolism BioSystems: KEGG 3.224E-6 2.286E-4 1.674E-3 2.743E-3 6 38
13 MAP00260 Glycine serine and threonine metabolism MAP00260 Glycine serine and threonine metabolism GenMAPP 4.241E-6 2.776E-4 2.033E-3 3.609E-3 5 23
14 413350 Serine biosynthesis, glycerate-3P => serine BioSystems: KEGG 5.142E-6 3.125E-4 2.289E-3 4.375E-3 3 4
15 530772 Activation of Genes by ATF4 BioSystems: REACTOME 8.074E-6 4.581E-4 3.355E-3 6.871E-3 5 26
16 PW:0000047 glycine, serine and threonine metabolic Pathway Ontology 1.277E-5 6.792E-4 4.974E-3 1.087E-2 4 14
17 105907 PERK regulated gene expression BioSystems: REACTOME 1.420E-5 7.107E-4 5.206E-3 1.208E-2 5 29
18 MAP00450 Selenoamino acid metabolism MAP00450 Selenoamino acid metabolism GenMAPP 2.530E-5 1.133E-3 8.298E-3 2.153E-2 3 6
19 413405 C1-unit interconversion, eukaryotes BioSystems: KEGG 2.530E-5 1.133E-3 8.298E-3 2.153E-2 3 6
20 105904 Unfolded Protein Response BioSystems: REACTOME 3.387E-5 1.441E-3 1.055E-2 2.882E-2 7 83
21 SMP00192 Hypoacetylaspartia SMPDB 3.773E-5 1.529E-3 1.120E-2 3.211E-2 4 18
22 83008 One carbon pool by folate BioSystems: KEGG 5.873E-5 2.272E-3 1.664E-2 4.998E-2 4 20
23 MAP00271 Methionine metabolism MAP00271 Methionine metabolism GenMAPP 6.970E-5 2.551E-3 1.868E-2
5.931E-2
 3 8
24 MAP00252 Alanine and aspartate metabolism MAP00252 Alanine and aspartate metabolism GenMAPP 7.193E-5 2.551E-3 1.868E-2
6.122E-2
 4 21
25 119559 Transport of inorganic cations/anions and amino acids/oligopeptides BioSystems: REACTOME 8.644E-5 2.942E-3 2.155E-2
7.356E-2
 7 96
26 SMP00013 Cysteine Metabolism SMPDB 1.037E-4 3.043E-3 2.229E-2
8.825E-2
 3 9
27 SMP00029 Selenoamino Acid Metabolism SMPDB 1.037E-4 3.043E-3 2.229E-2
8.825E-2
 3 9
28 MAP00272 Cysteine metabolism MAP00272 Cysteine metabolism GenMAPP 1.037E-4 3.043E-3 2.229E-2
8.825E-2
 3 9
29 PW:0000049 cysteine metabolic Pathway Ontology 1.037E-4 3.043E-3 2.229E-2
8.825E-2
 3 9
30 PW:0000400 transulfuration of homocysteine metabolism Pathway Ontology 1.199E-4 3.187E-3 2.334E-2
1.020E-1
 2 2
31 413414 Cysteine biosynthesis, homocysteine + serine => cysteine BioSystems: KEGG 1.199E-4 3.187E-3 2.334E-2
1.020E-1
 2 2
32 530754 Cysteine formation from homocysteine BioSystems: REACTOME 1.199E-4 3.187E-3 2.334E-2
1.020E-1
 2 2
33 739008 Trans-sulfuration pathway BioSystems: WikiPathways 1.470E-4 3.790E-3 2.776E-2
1.251E-1
 3 10
34 576262 Extracellular matrix organization BioSystems: REACTOME 1.518E-4 3.800E-3 2.783E-2
1.292E-1
 11 264
35 530770 Activation of Chaperone Genes by ATF6-alpha BioSystems: REACTOME 2.005E-4 4.874E-3 3.570E-2
1.706E-1
 3 11
36 106169 Metabolism of amino acids and derivatives BioSystems: REACTOME 2.705E-4 6.394E-3 4.683E-2
2.302E-1
 9 193
37 105905 Activation of Chaperones by ATF6-alpha BioSystems: REACTOME 3.419E-4 7.864E-3
5.760E-2
2.910E-1
 3 13
38 P02787 Vitamin B6 metabolism PantherDB 3.570E-4 7.994E-3
5.855E-2
3.038E-1
 2 3
39 101142 Alanine, aspartate and glutamate metabolism BioSystems: KEGG 3.937E-4 8.590E-3
6.292E-2
3.350E-1
 4 32
40 SMP00033 Methionine Metabolism SMPDB 5.353E-4 1.139E-2
8.341E-2
4.555E-1
 3 15
41 P02730 Asparagine and aspartate biosynthesis PantherDB 7.088E-4 1.471E-2
1.078E-1
6.032E-1
 2 4
42 106110 Integrin cell surface interactions BioSystems: REACTOME 7.729E-4 1.558E-2
1.141E-1
6.577E-1
 5 66
43 82969 Selenocompound metabolism BioSystems: KEGG 7.872E-4 1.558E-2
1.141E-1
6.699E-1
 3 17
44 833810 Non-integrin membrane-ECM interactions BioSystems: REACTOME 1.126E-3 2.178E-2
1.595E-1
9.582E-1
 4 42
45 142236 folate transformations BioSystems: BIOCYC 1.747E-3 3.162E-2
2.316E-1
1.000E0
 2 6
46 83013 Vitamin B6 metabolism BioSystems: KEGG 1.747E-3 3.162E-2
2.316E-1
1.000E0
 2 6
47 P02743 Formyltetrahydroformate biosynthesis PantherDB 1.747E-3 3.162E-2
2.316E-1
1.000E0
 2 6
48 PW:0000559 hexosamine biosynthetic Pathway Ontology 2.428E-3 4.251E-2
3.113E-1
1.000E0
 2 7
49 PW:0000048 methionine cycle/metabolic Pathway Ontology 2.498E-3 4.251E-2
3.113E-1
1.000E0
 3 25
50 530753 Sulfur amino acid metabolism BioSystems: REACTOME 2.498E-3 4.251E-2
3.113E-1
1.000E0
 3 25
Show 45 more annotations

8: Pubmed [Display Chart] 27514 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 24797263 Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. Pubmed 3.098E-12 8.523E-8 9.205E-7 8.523E-8 14 323
2 18195088 Amino acid transport across mammalian intestinal and renal epithelia. Pubmed 7.165E-12 9.856E-8 1.064E-6 1.971E-7 7 31
3 25147182 Quantitative Lys-¿-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. Pubmed 5.474E-11 5.020E-7 5.421E-6 1.506E-6 14 401
4 22190034 Global landscape of HIV-human protein complexes. Pubmed 3.228E-9 2.220E-5 2.398E-4 8.881E-5 13 457
5 16196087 Large-scale analysis of the human ubiquitin-related proteome. Pubmed 6.273E-9 3.452E-5 3.728E-4 1.726E-4 11 313
6 19581412 Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. Pubmed 7.987E-9 3.662E-5 3.955E-4 2.197E-4 6 46
7 25152457 Neu-Laxova syndrome is a heterogeneous metabolic disorder caused by defects in enzymes of the L-serine biosynthesis pathway. Pubmed 3.164E-8 9.672E-5 1.045E-3 8.705E-4 3 3
8 18940792 C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. Pubmed 3.164E-8 9.672E-5 1.045E-3 8.705E-4 3 3
9 18940792:gr C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. GeneRIF 3.164E-8 9.672E-5 1.045E-3 8.705E-4 3 3
10 20102225 Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays. Pubmed 5.766E-8 1.505E-4 1.626E-3 1.587E-3 5 32
11 25621764 Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. Pubmed 6.912E-8 1.505E-4 1.626E-3 1.902E-3 4 13
12 21319273 An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. Pubmed 7.084E-8 1.505E-4 1.626E-3 1.949E-3 11 397
13 18781797 Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. Pubmed 8.808E-8 1.505E-4 1.626E-3 2.424E-3 6 68
14 20628624:gr Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". GeneRIF 9.169E-8 1.505E-4 1.626E-3 2.523E-3 8 172
15 20628624 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". Pubmed 9.169E-8 1.505E-4 1.626E-3 2.523E-3 8 172
16 23661758 Networks of bZIP protein-protein interactions diversified over a billion years of evolution. Pubmed 1.232E-7 1.505E-4 1.626E-3 3.390E-3 5 37
17 23227240 CTGF increases IL-6 expression in human synovial fibroblasts through integrin-dependent signaling pathway. Pubmed 1.263E-7 1.505E-4 1.626E-3 3.474E-3 3 4
18 12370503 Polymorphisms in cytokine genes define subpopulations of HIV-1 patients who experienced immune restoration diseases. Pubmed 1.263E-7 1.505E-4 1.626E-3 3.474E-3 3 4
19 23227240:gr CTGF increases IL-6 expression in human synovial fibroblasts through integrin-dependent signaling pathway. GeneRIF 1.263E-7 1.505E-4 1.626E-3 3.474E-3 3 4
20 18638388:gr Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia. GeneRIF 1.263E-7 1.505E-4 1.626E-3 3.474E-3 3 4
21 12370503:gr Polymorphisms in cytokine genes define subpopulations of HIV-1 patients who experienced immune restoration diseases. GeneRIF 1.263E-7 1.505E-4 1.626E-3 3.474E-3 3 4
22 18638388 Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia. Pubmed 1.263E-7 1.505E-4 1.626E-3 3.474E-3 3 4
23 22934019 The endoplasmic reticulum stress response in aging and age-related diseases. Pubmed 1.313E-7 1.505E-4 1.626E-3 3.612E-3 4 15
24 18276110 E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3. Pubmed 1.313E-7 1.505E-4 1.626E-3 3.612E-3 4 15
25 20562859 Network organization of the human autophagy system. Pubmed 1.650E-7 1.816E-4 1.961E-3 4.540E-3 11 432
26 21890473 A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Pubmed 4.064E-7 4.301E-4 4.645E-3 1.118E-2 8 209
27 8635876 Isolation of genes differentially expressed in human primary myoblasts and embryonal rhabdomyosarcoma. Pubmed 6.283E-7 6.403E-4 6.915E-3 1.729E-2 3 6
28 12812986 DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Pubmed 6.915E-7 6.795E-4 7.338E-3 1.902E-2 4 22
29 12805554 Comprehensive identification of human bZIP interactions with coiled-coil arrays. Pubmed 8.350E-7 7.607E-4 8.216E-3 2.297E-2 4 23
30 17872950 Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. Pubmed 1.097E-6 7.607E-4 8.216E-3 3.018E-2 3 7
31 1371974 cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein. Pubmed 1.751E-6 7.607E-4 8.216E-3 4.818E-2 3 8
32 15775988 TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. Pubmed 1.751E-6 7.607E-4 8.216E-3 4.818E-2 3 8
33 21963094 Global identification of modular cullin-RING ligase substrates. Pubmed 1.836E-6 7.607E-4 8.216E-3
5.052E-2
 7 178
34 19048631:gr Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study. GeneRIF 2.206E-6 7.607E-4 8.216E-3
6.071E-2
 4 29
35 19048631 Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study. Pubmed 2.206E-6 7.607E-4 8.216E-3
6.071E-2
 4 29
36 24503185 Interleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progression. Pubmed 2.621E-6 7.607E-4 8.216E-3
7.210E-2
 3 9
37 25063885 KSHV attachment and entry are dependent on ¿V�3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate. Pubmed 2.621E-6 7.607E-4 8.216E-3
7.210E-2
 3 9
38 15901826 Metabolic activation-related CD147-CD98 complex. Pubmed 2.621E-6 7.607E-4 8.216E-3
7.210E-2
 3 9
39 23658023 Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. Pubmed 3.871E-6 7.607E-4 8.216E-3
1.065E-1
 5 73
40 21906983 Systematic and quantitative assessment of the ubiquitin-modified proteome. Pubmed 4.974E-6 7.607E-4 8.216E-3
1.368E-1
 7 207
41 26752685 FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. Pubmed 5.291E-6 7.607E-4 8.216E-3
1.456E-1
 6 136
42 19086053 Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. Pubmed 5.980E-6 7.607E-4 8.216E-3
1.645E-1
 8 300
43 19086053:gr Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. GeneRIF 5.980E-6 7.607E-4 8.216E-3
1.645E-1
 8 300
44 20301532 Charcot-Marie-Tooth Hereditary Neuropathy Overview Pubmed 6.015E-6 7.607E-4 8.216E-3
1.655E-1
 4 37
45 15057902:gr HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination. GeneRIF 6.815E-6 7.607E-4 8.216E-3
1.875E-1
 3 12
46 15057902 HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination. Pubmed 6.815E-6 7.607E-4 8.216E-3
1.875E-1
 3 12
47 19199708 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Pubmed 8.084E-6 7.607E-4 8.216E-3
2.224E-1
 9 414
48 11829477 Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex. Pubmed 8.839E-6 7.607E-4 8.216E-3
2.432E-1
 3 13
49 19948975:gr Integrative predictive model of coronary artery calcification in atherosclerosis. GeneRIF 9.609E-6 7.607E-4 8.216E-3
2.644E-1
 7 229
50 19948975 Integrative predictive model of coronary artery calcification in atherosclerosis. Pubmed 9.609E-6 7.607E-4 8.216E-3
2.644E-1
 7 229
Show 45 more annotations

9: Interaction [Display Chart] 3700 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:AARS AARS interactions 2.176E-9 8.050E-6 7.079E-5 8.050E-6 9 54
2 int:GARS GARS interactions 2.599E-7 4.808E-4 4.228E-3 9.615E-4 9 92
3 int:IARS IARS interactions 4.888E-7 6.029E-4 5.301E-3 1.809E-3 9 99
4 int:ASNS ASNS interactions 1.508E-6 1.153E-3 1.014E-2 5.581E-3 8 84
5 int:GFPT1 GFPT1 interactions 1.558E-6 1.153E-3 1.014E-2 5.765E-3 7 59
6 int:LARS LARS interactions 4.117E-6 2.539E-3 2.232E-2 1.523E-2 7 68
7 int:CREB3 CREB3 interactions 1.778E-5 7.288E-3
6.408E-2
6.578E-2
 10 192
8 int:ERBB4 ERBB4 interactions 1.997E-5 7.288E-3
6.408E-2
7.388E-2
 6 58
9 int:NMD3 NMD3 interactions 1.997E-5 7.288E-3
6.408E-2
7.388E-2
 6 58
10 int:ZYX ZYX interactions 2.128E-5 7.288E-3
6.408E-2
7.873E-2
 7 87
11 int:HSPE1 HSPE1 interactions 2.167E-5 7.288E-3
6.408E-2
8.016E-2
 8 120
12 int:TRIB3 TRIB3 interactions 3.091E-5 9.531E-3
8.381E-2
1.144E-1
 5 38
13 int:ALDH7A1 ALDH7A1 interactions 3.518E-5 1.001E-2
8.805E-2
1.302E-1
 5 39
14 int:TPD52L2 TPD52L2 interactions 4.206E-5 1.111E-2
9.774E-2
1.556E-1
 6 66
15 int:FARSB FARSB interactions 4.508E-5 1.112E-2
9.779E-2
1.668E-1
 5 41
16 int:ITGB1 ITGB1 interactions 9.086E-5 2.101E-2
1.848E-1
3.362E-1
 7 109
17 int:CEBPE CEBPE interactions 9.754E-5 2.123E-2
1.867E-1
3.609E-1
 5 48
18 int:TARS TARS interactions 1.081E-4 2.143E-2
1.884E-1
3.999E-1
 6 78
19 int:EPRS EPRS interactions 1.140E-4 2.143E-2
1.884E-1
4.219E-1
 7 113
20 int:HARS HARS interactions 1.188E-4 2.143E-2
1.884E-1
4.397E-1
 5 50
21 int:CEBPG CEBPG interactions 1.246E-4 2.143E-2
1.884E-1
4.610E-1
 4 27
22 int:PSPH PSPH interactions 1.386E-4 2.143E-2
1.884E-1
5.129E-1
 3 11
23 int:DARS DARS interactions 1.427E-4 2.143E-2
1.884E-1
5.281E-1
 6 82
24 int:RARS RARS interactions 1.435E-4 2.143E-2
1.884E-1
5.310E-1
 5 52
25 int:TMEM17 TMEM17 interactions 1.448E-4 2.143E-2
1.884E-1
5.357E-1
 13 401
26 int:TTC1 TTC1 interactions 1.856E-4 2.642E-2
2.323E-1
6.869E-1
 6 86
27 int:PROSC PROSC interactions 2.618E-4 3.425E-2
3.012E-1
9.687E-1
 5 59
28 int:WDR27 WDR27 interactions 2.774E-4 3.425E-2
3.012E-1
1.000E0
 2 3
29 int:ERVW-1 ERVW-1 interactions 2.774E-4 3.425E-2
3.012E-1
1.000E0
 2 3
30 int:FOSL1 FOSL1 interactions 2.777E-4 3.425E-2
3.012E-1
1.000E0
 4 33
31 int:ATF5 ATF5 interactions 2.993E-4 3.573E-2
3.142E-1
1.000E0
 3 14
32 int:PICALM PICALM interactions 3.195E-4 3.694E-2
3.249E-1
1.000E0
 6 95
33 int:COLEC10 COLEC10 interactions 3.715E-4 4.165E-2
3.663E-1
1.000E0
 3 15
34 int:CBS CBS interactions 4.123E-4 4.487E-2
3.945E-1
1.000E0
 5 65
35 int:RTFDC1 RTFDC1 interactions 4.540E-4 4.666E-2
4.103E-1
1.000E0
 3 16
36 int:DYRK4 DYRK4 interactions 4.540E-4 4.666E-2
4.103E-1
1.000E0
 3 16
Show 31 more annotations

10: Cytoband [Display Chart] 150 annotations before applied cutoff / 34661 genes in category

No results to display

11: Transcription Factor Binding Site [Display Chart] 504 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 82 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 132 Aminoacyl tRNA synthetases, Class II genenames.org 4.480E-8 1.837E-6 9.166E-6 3.674E-6 5 19
2 131 Aminoacyl tRNA synthetases, Class I genenames.org 4.480E-8 1.837E-6 9.166E-6 3.674E-6 5 19
3 506 Basic leucine zipper proteins genenames.org 6.465E-6 1.767E-4 8.818E-4 5.301E-4 5 49
4 1160 CD molecules|Integrin alpha subunits genenames.org 1.166E-4 2.390E-3 1.193E-2 9.562E-3 3 18
5 593 CD molecules|V-set domain containing|I-set domain containing|Sialic acid binding Ig like lectins genenames.org 2.353E-4 3.833E-3 1.913E-2 1.930E-2 6 161
6 752 Pseudoautosomal region 1|Solute carriers genenames.org 2.805E-4 3.833E-3 1.913E-2 2.300E-2 9 395
Show 1 more annotation

13: Coexpression [Display Chart] 6347 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M7300 Selected genes up-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.135E-47 3.894E-43 3.634E-42 3.894E-43 43 245
2 M3185 Genes down-regulated in at least one of three multiple myeloma (MM) cell lines treated with the DNA hypomethylating agent decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.609E-31 2.097E-27 1.958E-26 4.195E-27 25 105
3 M2757 Genes up-regulated in CEM-C1 cells (T-CLL) by everolimus [PubChem = 6442177], an mTOR pathway inhibitor. MSigDB C6: Oncogenic Signatures (v5.1) 2.440E-29 5.161E-26 4.817E-25 1.548E-25 29 196
4 M19666 Genes down-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 24h. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.390E-28 5.380E-25 5.021E-24 2.152E-24 29 214
5 M6092 Genes up-regulated in CD4 [GeneID=920] T cells: untreated (0h) versus activated by anti-CD3 and anti-CD28 and then stimulated by IL-12 (6h). MSigDB C7: Immunologic Signatures (v5.1) 1.198E-27 1.521E-24 1.419E-23 7.603E-24 28 200
6 M19341 The 'amino acid deprivation response' (AADR): genes up-regulated in HL-60 cells (acute promyelocytic leukemia, APL) after amino acid deprivation or treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.955E-27 3.125E-24 2.917E-23 1.875E-23 16 29
7 M1679 Genes up-regulated in CD-1 compared to CD-2 cluster of multiple myeloma samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.851E-25 1.679E-22 1.567E-21 1.175E-21 19 66
8 M11280 Genes up-regulated in BJAB cells (B-lymphoma) after leucine [PubChem=857] deprivation. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.393E-24 1.899E-21 1.772E-20 1.519E-20 23 142
9 M16336 Up-regulated genes in MM1.S cells (multiple myeloma) treated with adaphostin [PubChem=387042], a tyrosine kinase inhibitor with anticancer properties. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.542E-22 1.087E-19 1.015E-18 9.785E-19 22 147
10 M5924 Genes up-regulated through activation of mTORC1 complex. MSigDB H: Hallmark Gene Sets (v5.1) 7.762E-21 4.926E-18 4.598E-17 4.926E-17 23 200
11 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.456E-21 5.456E-18 5.092E-17 6.001E-17 30 425
12 M2774 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of ALK [Gene ID=238] gene by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 4.968E-20 2.628E-17 2.453E-16 3.153E-16 20 142
13 M7623 Genes down-regulated in multiple myeloma (MM) cell lines treated with both decitabine [PubChem=451668] TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.108E-20 3.958E-17 3.694E-16 5.146E-16 25 281
14 M10839 Down-regulated genes in MDA-MB-435 cells (breast cancer) undergoing G2/M arrest after treatment with 2-methoxyestradiol (2ME2) [PubChem=1573]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.359E-19 5.848E-17 5.458E-16 8.625E-16 19 127
15 M1190 Top 50 up-regulated genes in cluster CD-1 of multiple myeloma samples with the characteristic expression spike of CCND1 [GeneID=595]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.382E-19 5.848E-17 5.458E-16 8.772E-16 14 45
16 M16574 Genes up-regulated in MCF7 cells (breast cancer) by IGF1 and IGF2 [GeneID=3479;3481]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.875E-19 7.295E-17 6.808E-16 1.190E-15 13 35
17 M17693 Genes up-regulated in Daudi cells (B lymphocytes) stably expressing CD5 [GeneID=921] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.954E-19 7.295E-17 6.808E-16 1.240E-15 30 473
18 M2314 Genes down-regulated in DL23 cells (colon cancer) upon expression of an activated form of FOXO3 [GeneID=2309]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.153E-18 7.591E-16 7.084E-15 1.366E-14 13 41
19 M4035 Genes from the red module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC). MSigDB C2: CGP Curated Gene Sets (v5.1) 7.929E-18 2.649E-15 2.472E-14 5.033E-14 10 17
20 M6890 Genes down-regulated in at least one of three multiple myeloma (MM) cell lines by TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.735E-17 1.185E-14 1.106E-13 2.371E-13 23 291
21 M2779 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 and PCGF2 [Gene ID=648, 7703] genes by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 4.010E-17 1.212E-14 1.131E-13 2.545E-13 18 145
22 M5922 Genes up-regulated during unfolded protein response, a cellular stress response related to the endoplasmic reticulum. MSigDB H: Hallmark Gene Sets (v5.1) 2.819E-16 8.132E-14 7.590E-13 1.789E-12 16 113
23 M6935 Genes down-regulated in B lymphocytes: anti IgM versus anti IgM and CpG oligodeoxynucleotide 1826. MSigDB C7: Immunologic Signatures (v5.1) 8.153E-16 2.196E-13 2.050E-12 5.174E-12 19 200
24 M17742 Genes consistently up-regulated in HMEC cells (primary mammary epithelium) upon expression of TERT [GeneID=7015] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.305E-16 2.196E-13 2.050E-12 5.271E-12 17 145
25 M2487 Genes up-regulated in HeLa cells (cervical carcinoma) upon knockdown of PHF8 [GeneID=23133] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.562E-15 6.504E-13 6.071E-12 1.626E-11 21 279
26 M6938 Genes down-regulated in B lymphocytes: CpG oligodeoxynucleotide 1826 versus PL2-3 (Chromatin IC). MSigDB C7: Immunologic Signatures (v5.1) 1.260E-14 2.962E-12 2.764E-11 7.997E-11 18 200
27 M4638 Genes down-regulated in comparison of CD25- T cells treated with IL4 [GeneID=3565] at day 7 versus untreated CD25- T cells at day 7. MSigDB C7: Immunologic Signatures (v5.1) 1.260E-14 2.962E-12 2.764E-11 7.997E-11 18 200
28 M18806 Down-regulated genes in Calu3 cells (non-small cell lung cancer, NSCLC) resistant to gemcitabine [PubChem=3461] which became up-regulated in response to bexarotene [PubChem=82146]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.150E-14 4.873E-12 4.548E-11 1.364E-10 15 122
29 M1784 Genes changed in U373-MG cells (malignant glioma) upon treatment with arsenic trioxide [PubChem=14888], a chemical that can cause autophagic cell death. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.432E-14 5.324E-12 4.969E-11 1.544E-10 15 123
30 M1304 Genes down-regulated in SEND cells (skin endothelium) at hypoxia with ELK3 [GeneID=2004] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.120E-14 1.071E-11 9.995E-11 3.249E-10 16 156
31 M262 Genes discriminating responses to sodium arsenite [PubChem=26435] from other stresses. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.231E-14 1.071E-11 9.995E-11 3.320E-10 18 217
32 M4716 Genes up-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402], a protease inhibitor causing apoptosis. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.768E-13 5.490E-11 5.124E-10 1.757E-9 18 239
33 M9780 Representative genes up-regulated in MiaPaCa2 cells (pancreatic cancer) under glucose-deprived conditions. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.512E-13 1.445E-10 1.348E-9 4.768E-9 11 60
34 M2427 Genes down-regulated in pancreatic cancer cells grown in orthotopic xenograft tumors compared to those grown in vitro. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.380E-12 2.575E-10 2.404E-9 8.756E-9 10 46
35 M3666 Genes up-regulated in comparison of stimulated naive CD8 T cells from pmel-1 mice versus unstimulated naive CD8 T cells from pmel-1 mice. MSigDB C7: Immunologic Signatures (v5.1) 2.462E-12 4.341E-10 4.051E-9 1.563E-8 16 200
36 M6941 Genes down-regulated in B lymphocytes: CpG oligodeoxynucleotide 1826 versus anti IgM and CpG oligodeoxynucleotide 1826. MSigDB C7: Immunologic Signatures (v5.1) 2.462E-12 4.341E-10 4.051E-9 1.563E-8 16 200
37 M4932 Genes up-regulated in HeLa cells (cervical carcinoma) by trabectedin [PubChem=3199]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.693E-12 4.619E-10 4.311E-9 1.709E-8 11 67
38 M10427 Up-regulated in brown preadipocytes with IRS1 [GeneID=3667] knockout vs wild type controls; the knockouts have severe defects in adipocyte differentiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.950E-12 4.928E-10 4.599E-9 1.872E-8 13 113
39 M2784 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of PCGF2 [Gene ID=7703] gene by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 3.228E-12 5.253E-10 4.902E-9 2.049E-8 14 141
40 M4779 Genes down-regulated in A549 cells (lung cancer) after knockdown of ATF4 [GeneID=468] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.486E-12 5.532E-10 5.163E-9 2.213E-8 12 90
41 M2128 Genes up-regulated in growing IMR90 cells (fibroblast) after knockdown of RB1 [GeneID=5925] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.305E-12 6.665E-10 6.221E-9 2.733E-8 17 243
42 M13867 Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.898E-12 1.496E-9 1.396E-8 6.282E-8 17 256
43 M5784 IRF4 [GeneID=3662] target genes up-regulated in primary myeloma vs. mature B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.413E-11 2.086E-9 1.947E-8 8.971E-8 12 101
44 M3237 Genes down-regulated in comparison of memory CD4 [GeneID=920] T cells treated with retinoic acid (tretinoin) [PubChem=444795] versus untreated memory CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v5.1) 3.094E-11 4.363E-9 4.072E-8 1.964E-7 15 200
45 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v5.1) 3.094E-11 4.363E-9 4.072E-8 1.964E-7 15 200
46 M2870 Genes up-regulated in MEF cells (embryonic fibroblasts) with knockout of NFE2L2 [Gene ID=4780] gene. MSigDB C6: Oncogenic Signatures (v5.1) 7.577E-11 1.046E-8 9.758E-8 4.809E-7 21 476
47 M6562 Genes up-regulated by 2-methoxyestradiol (2ME2) [PubChem=1573] in the MM.1S cell line (multiple myeloma) sensitive to dexamethasone [PubChem=5743]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.398E-10 1.889E-8 1.763E-7 8.876E-7 9 51
48 M2439 Genes down-regulated in G1ME cells (megakaryocyte/erythroid progenitor lacking GATA1 [GeneID=2623]) upon knockdown of GATA2 [GeneID=2624] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.536E-10 2.031E-8 1.895E-7 9.747E-7 10 72
49 M1531 Genes most consistently regulated at 24 h by all six genotoxins tested: cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide [PubChem=2767;4156;5746;4666;3657;36462]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.670E-10 2.164E-8 2.019E-7 1.060E-6 8 35
50 M18757 Genes up-regulated in HMLE cells (mmortalized nontransformed mammary epithelial) by expression of a dominant-negative form of E-cadhedrin (CDH1) [GeneID=999]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.722E-10 8.533E-8 7.963E-7 4.266E-6 12 140
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2626 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PCBC ratio SC-LF blastocyst vs SC blastocyst cfr-2X-p05 SC-LF blastocyst vs SC blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 3.710E-22 9.744E-19 8.234E-18 9.744E-19 31 396
2 JC fibro 1000 K3 JC fibro top-relative-expression-ranked 1000 k-means-cluster#3 PCBC 2.807E-19 3.685E-16 3.114E-15 7.370E-16 19 126
3 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 1.288E-13 1.127E-10 9.526E-10 3.382E-10 25 493
4 80Dn SubClass 80Dn 1 Top 500 Cluster 0 80Dn SubClass 80Dn 1 Top 500 Cluster 0 Brain Map - Allen iN 4.401E-11 1.826E-8 1.543E-7 1.156E-7 22 489
5 80Dn SubClass 80Dn 1 Top 500 All 80Dn SubClass 80Dn 1 Top 500 All Brain Map - Allen iN 4.401E-11 1.826E-8 1.543E-7 1.156E-7 22 489
6 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 5.226E-11 1.826E-8 1.543E-7 1.372E-7 21 445
7 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 5.351E-11 1.826E-8 1.543E-7 1.405E-7 22 494
8 endothelial SubClass DCN-hi Top 500 All endothelial SubClass DCN-hi Top 500 All Brain Map - Barres 5.563E-11 1.826E-8 1.543E-7 1.461E-7 22 495
9 PCBC ratio MESO-5 from-ESC vs MESO-5 from-retro cfr-2X-p05 Mesoderm Day 5-method NA vs Mesoderm Day 5-method retro-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 3.053E-10 8.018E-8 6.776E-7 8.018E-7 9 53
10 PCBC ratio MESO-5 from-ESC vs MESO-5 from-OSKM cfr-2X-p05 Mesoderm Day 5-reprogram NA vs Mesoderm Day 5-reprogram OSKM-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 3.053E-10 8.018E-8 6.776E-7 8.018E-7 9 53
11 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 4.997E-10 1.181E-7 9.976E-7 1.312E-6 20 453
12 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 5.395E-10 1.181E-7 9.976E-7 1.417E-6 20 455
13 astrocytes Top 500 All astrocytes Top 500 All Brain Map - Barres 2.385E-9 4.818E-7 4.072E-6 6.263E-6 20 496
14 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 1.408E-8 2.642E-6 2.233E-5 3.699E-5 19 496
15 PP MEG 2500 K3 PP MEG top-relative-expression-ranked 2500 k-means-cluster#3 PCBC 2.374E-8 4.155E-6 3.511E-5 6.233E-5 13 222
16 JC fibro 1000 K1 JC fibro top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 2.865E-8 4.703E-6 3.974E-5 7.525E-5 18 464
17 ratio SC vs ECTO 2500 K5 ratio StemCell vs induced-Ectoderm top-relative-expression-ranked 2500 k-means-cluster#5 PCBC 3.703E-8 5.720E-6 4.834E-5 9.724E-5 16 368
18 gudmap kidney adult Mesangium Meis 500 kidney adult Mesangium Meis top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.239E-8 7.644E-6 6.459E-5 1.376E-4 17 429
19 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 7.065E-8 9.764E-6 8.251E-5 1.855E-4 17 438
20 PCBC ratio MESO-5 blastocyst vs MESO-5 fibroblast cfr-2X-p05 MESO-5 blastocyst vs MESO-5 fibroblast-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 9.214E-8 1.128E-5 9.532E-5 2.420E-4 7 48
21 PCBC ratio MESO-5 from-ESC vs MESO-5 from-OSKM-L cfr-2X-p05 Mesoderm Day 5-reprogram NA vs Mesoderm Day 5-reprogram OSKM-L-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 9.450E-8 1.128E-5 9.532E-5 2.481E-4 10 132
22 PCBC ratio MESO-5 from-ESC vs MESO-5 from-mRNA cfr-2X-p05 Mesoderm Day 5-method NA vs Mesoderm Day 5-method mRNA-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 9.450E-8 1.128E-5 9.532E-5 2.481E-4 10 132
23 ratio SC vs ECTO 1000 K3 ratio StemCell vs induced-Ectoderm top-relative-expression-ranked 1000 k-means-cluster#3 PCBC 1.253E-7 1.431E-5 1.209E-4 3.290E-4 10 136
24 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 1.467E-7 1.605E-5 1.356E-4 3.852E-4 17 461
25 PCBC ratio ESC vs iPSC method-OS-NL cfr-2X-p05 Pluripotent Stem Cells-reprogram NA vs Pluripotent Stem Cells-reprogram OS-NL-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.818E-7 1.909E-5 1.613E-4 4.773E-4 8 78
26 gudmap kidney adult JuxtaGlom Ren1 Captopr k3 1000 kidney adult JuxtaGlom Ren1 Captopr k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.118E-7 3.149E-5 2.661E-4 8.187E-4 7 57
27 GSM777063 500 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 5.651E-7 5.496E-5 4.645E-4 1.484E-3 16 450
28 astrocytes Top 500 Cluster 4 astrocytes Top 500 Cluster 4 Brain Map - Barres 8.000E-7 7.503E-5 6.341E-4 2.101E-3 10 166
29 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.093E-7 8.234E-5 6.958E-4 2.388E-3 15 410
30 gudmap kidney e15.5 Podocyte MafB 500 kidney e15.5 Podocyte MafB top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.959E-7 8.718E-5 7.367E-4 2.615E-3 15 413
31 gudmap RNAseq e15.5 Podocytes 2500 K2 gudmap RNAseq e15.5 Podocytes 2500 K2 Gudmap RNAseq 2.543E-6 2.154E-4 1.820E-3 6.677E-3 13 334
32 GSM777037 500 Stromal Cells, BEC.SLN, gp38- CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 3.650E-6 2.995E-4 2.531E-3 9.584E-3 15 459
33 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 4.498E-6 3.579E-4 3.025E-3 1.181E-2 15 467
34 GSM777067 100 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 4.840E-6 3.738E-4 3.159E-3 1.271E-2 7 85
35 Lungmap Mouse e16.5 Epithelial (GSE52583) Top 500 Cluster 1 Mouse Lung E16.5 Epithelial GSE52583 top 500 c1 Lungmap Mouse Single Cell (Lungmap.net) 5.571E-6 4.180E-4 3.532E-3 1.463E-2 8 122
36 54Dn Top 500 Cluster 1 54Dn Top 500 Cluster 1 Brain Map - Allen iN 6.195E-6 4.519E-4 3.819E-3 1.627E-2 9 164
37 54Dn SubClass 54Dn 1SK Top 500 Cluster 2 54Dn SubClass 54Dn 1SK Top 500 Cluster 2 Brain Map - Allen iN 8.426E-6 5.980E-4 5.054E-3 2.213E-2 11 265
38 12Dn Top 500 All 12Dn Top 500 All Brain Map - Allen iN 9.029E-6 6.240E-4 5.273E-3 2.371E-2 15 495
39 JC fibro 500 JC fibro top-relative-expression-ranked 500 PCBC 9.472E-6 6.378E-4 5.389E-3 2.487E-2 15 497
40 GSM777059 500 Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.028E-5 6.748E-4 5.703E-3 2.699E-2 14 439
41 endothelial SubClass DCN-hi Top 500 Cluster 2 endothelial SubClass DCN-hi Top 500 Cluster 2 Brain Map - Barres 1.175E-5 7.433E-4 6.282E-3 3.087E-2 8 135
42 gudmap kidney P4 CapMesRenVes Crym k1 1000 kidney P4 CapMesRenVes Crym k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.218E-5 7.433E-4 6.282E-3 3.198E-2 6 65
43 gudmap kidney adult RenalCapsule k4 1000 kidney adult RenalCapsule k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.241E-5 7.433E-4 6.282E-3 3.258E-2 8 136
44 gudmap dev gonad e12.5 M InterstitLeydig MafB k1 500 dev gonad e12.5 M InterstitLeydig MafB k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.245E-5 7.433E-4 6.282E-3 3.271E-2 7 98
45 12Dn Top 500 Cluster 2 12Dn Top 500 Cluster 2 Brain Map - Allen iN 1.380E-5 7.880E-4 6.659E-3 3.625E-2 8 138
46 gudmap kidney adult CortVasc Tie2 k4 1000 kidney adult CortVasc Tie2 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.380E-5 7.880E-4 6.659E-3 3.625E-2 8 138
47 gudmap RNAseq p2 Glomerlular Endothelial 2500 K4 gudmap RNAseq p2 Glomerlular Endothelial 2500 K4 Gudmap RNAseq 1.427E-5 7.970E-4 6.735E-3 3.746E-2 13 392
48 gudmap kidney adult Mesangium Meis k4 500 kidney adult Mesangium Meis k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.493E-5 8.170E-4 6.904E-3 3.922E-2 5 40
49 gudmap kidney P0 JuxtaGlom Ren1 500 kidney P0 JuxtaGlom Ren1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.572E-5 8.303E-4 7.017E-3 4.128E-2 14 456
50 endothelial SubClass DCN-hi Top 500 Cluster 1 endothelial SubClass DCN-hi Top 500 Cluster 1 Brain Map - Barres 1.581E-5 8.303E-4 7.017E-3 4.152E-2 10 232
Show 45 more annotations

15: Computational [Display Chart] 451 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 133 Genes in module 133 MSigDb: C4 - CM: Cancer Modules 3.332E-12 7.514E-10 5.027E-9 1.503E-9 8 15
2 module 160 Genes in module 160 MSigDb: C4 - CM: Cancer Modules 3.332E-12 7.514E-10 5.027E-9 1.503E-9 8 15
3 module 110 Genes in module 110 MSigDb: C4 - CM: Cancer Modules 2.742E-10 4.122E-8 2.757E-7 1.237E-7 7 15
4 module 35 Genes in module 35 MSigDb: C4 - CM: Cancer Modules 4.823E-10 5.438E-8 3.638E-7 2.175E-7 7 16
5 MORF EI24 Neighborhood of EI24 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.692E-7 1.526E-5 1.021E-4 7.632E-5 12 138
6 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 1.900E-5 1.428E-3 9.554E-3 8.569E-3 12 216
7 module 17 Genes in module 17 MSigDb: C4 - CM: Cancer Modules 4.052E-5 2.610E-3 1.746E-2 1.827E-2 15 353
8 module 122 Genes in module 122 MSigDb: C4 - CM: Cancer Modules 6.429E-5 3.408E-3 2.280E-2 2.899E-2 9 138
9 MORF RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.801E-5 3.408E-3 2.280E-2 3.067E-2 9 139
10 module 428 Genes in module 428 MSigDb: C4 - CM: Cancer Modules 1.085E-4 4.892E-3 3.273E-2 4.892E-2 3 8
11 MORF BUB1B Neighborhood of BUB1B MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.196E-4 4.904E-3 3.281E-2
5.395E-2
 6 61
12 MORF PPP1CC Neighborhood of PPP1CC MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.424E-4 5.353E-3 3.581E-2
6.424E-2
 9 153
13 module 471 Genes in module 471 MSigDb: C4 - CM: Cancer Modules 1.612E-4 5.592E-3 3.741E-2
7.270E-2
 3 9
14 module 528 Genes in module 528 MSigDb: C4 - CM: Cancer Modules 2.281E-4 7.349E-3 4.917E-2
1.029E-1
 3 10
15 module 3 Genes in module 3 MSigDb: C4 - CM: Cancer Modules 2.898E-4 8.714E-3
5.829E-2
1.307E-1
 14 375
16 MORF BUB1 Neighborhood of BUB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.178E-4 1.178E-2
7.878E-2
1.884E-1
 5 50
17 module 321 Genes in module 321 MSigDb: C4 - CM: Cancer Modules 4.461E-4 1.183E-2
7.917E-2
2.012E-1
 7 108
18 GNF2 RAN Neighborhood of RAN MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.317E-4 1.332E-2
8.912E-2
2.398E-1
 6 80
19 module 8 Genes in module 8 MSigDb: C4 - CM: Cancer Modules 6.437E-4 1.528E-2
1.022E-1
2.903E-1
 14 406
20 MORF RAD23A Neighborhood of RAD23A MSigDb: C4 - CGN: Cancer Gene Neighborhood 7.709E-4 1.738E-2
1.163E-1
3.477E-1
 12 320
21 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 8.764E-4 1.882E-2
1.259E-1
3.953E-1
 14 419
22 GNF2 PTX3 Neighborhood of PTX3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.086E-3 2.225E-2
1.489E-1
4.896E-1
 4 36
23 MORF RAD54L Neighborhood of RAD54L MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.247E-3 2.376E-2
1.589E-1
5.622E-1
 6 94
24 module 18 Genes in module 18 MSigDb: C4 - CM: Cancer Modules 1.285E-3 2.376E-2
1.589E-1
5.796E-1
 14 436
25 MORF PTPN11 Neighborhood of PTPN11 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.317E-3 2.376E-2
1.589E-1
5.939E-1
 6 95
26 MORF BUB3 Neighborhood of BUB3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.771E-3 3.072E-2
2.055E-1
7.986E-1
 10 260
Show 21 more annotations

16: MicroRNA [Display Chart] 1175 annotations before applied cutoff / 19844 genes in category

No results to display

17: Drug [Display Chart] 20569 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 4018 UP Niclosamide [50-65-7]; Up 200; 12.2uM; PC3; HT HG-U133A Broad Institute CMAP 4.241E-46 8.722E-42 9.166E-41 8.722E-42 38 168
2 5962 UP valinomycin; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 6.001E-45 6.172E-41 6.486E-40 1.234E-40 38 179
3 5911 UP valinomycin; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 8.354E-43 5.728E-39 6.019E-38 1.718E-38 37 184
4 7103 UP thapsigargin; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.303E-39 6.701E-36 7.042E-35 2.680E-35 34 166
5 1916 UP Niclosamide [50-65-7]; Up 200; 12.2uM; PC3; HG-U133A Broad Institute CMAP 4.824E-39 1.984E-35 2.085E-34 9.922E-35 34 172
6 3740 UP Gossypol [303-45-7]; Up 200; 7.8uM; PC3; HT HG-U133A Broad Institute CMAP 1.834E-33 6.286E-30 6.606E-29 3.772E-29 31 182
7 4136 UP Niclosamide [50-65-7]; Up 200; 12.2uM; MCF7; HT HG-U133A Broad Institute CMAP 3.067E-29 9.013E-26 9.471E-25 6.309E-25 27 158
8 5777 UP Spiperone [749-02-0]; Up 200; 10.2uM; PC3; HT HG-U133A Broad Institute CMAP 6.255E-29 1.608E-25 1.690E-24 1.287E-24 27 162
9 4586 UP Cyclosporin A [59865-13-3]; Up 200; 3.4uM; PC3; HT HG-U133A Broad Institute CMAP 3.418E-28 7.811E-25 8.208E-24 7.029E-24 27 172
10 4325 UP Methyl benzethonium chloride [25155-18-4]; Up 200; 8.6uM; PC3; HT HG-U133A Broad Institute CMAP 1.180E-27 2.427E-24 2.550E-23 2.427E-23 26 159
11 1140 UP MG-132; Up 200; 21uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.660E-27 3.103E-24 3.261E-23 3.414E-23 26 161
12 3310 UP Puromycin dihydrochloride [58-58-2]; Up 200; 7.4uM; MCF7; HT HG-U133A Broad Institute CMAP 3.239E-27 5.551E-24 5.834E-23 6.661E-23 26 165
13 893 UP pararosaniline base; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 2.167E-26 3.429E-23 3.604E-22 4.458E-22 26 177
14 956 UP 5224221; Up 200; 12uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.105E-25 1.624E-22 1.707E-21 2.274E-21 25 166
15 D004002 Clodronic Acid CTD 1.856E-25 2.545E-22 2.674E-21 3.817E-21 28 241
16 C059262 cidofovir CTD 3.236E-25 4.160E-22 4.372E-21 6.656E-21 29 273
17 839 UP 5224221; Up 200; 12uM; MCF7; HT HG-U133A EA Broad Institute CMAP 7.776E-25 8.886E-22 9.338E-21 1.599E-20 25 179
18 5074 UP Chlorpromazine hydrochloride [69-09-0]; Up 200; 11.2uM; PC3; HT HG-U133A Broad Institute CMAP 7.776E-25 8.886E-22 9.338E-21 1.599E-20 25 179
19 1498 UP Niclosamide [50-65-7]; Up 200; 12.2uM; MCF7; HT HG-U133A Broad Institute CMAP 1.929E-24 2.089E-21 2.195E-20 3.969E-20 24 163
20 7053 UP thapsigargin; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 5.477E-24 5.633E-21 5.919E-20 1.127E-19 24 170
21 C004656 chloroacetaldehyde CTD 7.859E-24 7.697E-21 8.089E-20 1.616E-19 29 305
22 3637 UP Gossypol [303-45-7]; Up 200; 7.8uM; MCF7; HT HG-U133A Broad Institute CMAP 2.242E-23 2.097E-20 2.203E-19 4.612E-19 24 180
23 3699 UP Alexidine dihydrochloride [22573-93-9]; Up 200; 6.8uM; PC3; HT HG-U133A Broad Institute CMAP 2.942E-23 2.631E-20 2.764E-19 6.050E-19 24 182
24 6339 UP Pyrvinium pamoate [3546-41-6]; Up 200; 3.4uM; PC3; HT HG-U133A Broad Institute CMAP 3.365E-23 2.884E-20 3.031E-19 6.921E-19 24 183
25 344 UP 2-deoxy-D-glucose; Up 200; 10000uM; MCF7; HG-U133A Broad Institute CMAP 5.012E-23 3.965E-20 4.167E-19 1.031E-18 24 186
26 6438 UP 5707885; Up 200; 50uM; PC3; HT HG-U133A Broad Institute CMAP 5.012E-23 3.965E-20 4.167E-19 1.031E-18 24 186
27 4471 UP Astemizole [68844-77-9]; Up 200; 8.8uM; PC3; HT HG-U133A Broad Institute CMAP 1.205E-22 8.851E-20 9.301E-19 2.478E-18 23 169
28 6948 UP 15d-PGJ2; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.205E-22 8.851E-20 9.301E-19 2.478E-18 23 169
29 541 UP Iressa; Up 200; 10uM; HL60; HG-U133A Broad Institute CMAP 1.588E-22 1.127E-19 1.184E-18 3.267E-18 24 195
30 D008687 Metformin CTD 5.180E-22 3.552E-19 3.732E-18 1.066E-17 30 388
31 1905 UP Thioridazine hydrochloride [130-61-0]; Up 200; 9.8uM; PC3; HG-U133A Broad Institute CMAP 6.873E-22 4.561E-19 4.793E-18 1.414E-17 23 182
32 1011 UP 15d-PGJ2; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 7.336E-22 4.716E-19 4.956E-18 1.509E-17 22 159
33 C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) CTD 8.028E-22 5.004E-19 5.258E-18 1.651E-17 32 468
34 5957 UP valinomycin; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 8.874E-22 5.369E-19 5.642E-18 1.825E-17 23 184
35 D007069 Ifosfamide CTD 2.170E-21 1.275E-18 1.340E-17 4.464E-17 25 245
36 7063 UP MG-262; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 3.310E-21 1.891E-18 1.987E-17 6.808E-17 22 170
37 870 UP pyrvinium pamoate; Up 200; 1.25uM; MCF7; HT HG-U133A EA Broad Institute CMAP 8.165E-21 4.539E-18 4.770E-17 1.679E-16 22 177
38 5906 UP valinomycin; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 2.185E-20 1.183E-17 1.243E-16 4.494E-16 22 185
39 5439 UP Pyrvinium pamoate [3546-41-6]; Up 200; 3.4uM; MCF7; HT HG-U133A Broad Institute CMAP 2.336E-20 1.232E-17 1.295E-16 4.806E-16 21 161
40 1069 UP 15d-PGJ2; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 2.668E-20 1.372E-17 1.442E-16 5.487E-16 21 162
41 4296 UP Gossypol [303-45-7]; Up 200; 7.8uM; PC3; HT HG-U133A Broad Institute CMAP 3.122E-20 1.566E-17 1.646E-16 6.421E-16 22 188
42 7100 UP thapsigargin; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 5.801E-20 2.841E-17 2.986E-16 1.193E-15 21 168
43 1230 UP thioridazine hydrochloride; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 1.981E-19 9.477E-17 9.959E-16 4.075E-15 21 178
44 2049 UP Astemizole [68844-77-9]; Up 200; 8.8uM; PC3; HT HG-U133A Broad Institute CMAP 3.169E-19 1.482E-16 1.557E-15 6.519E-15 21 182
45 C032668 1-nitropyrene CTD 6.378E-19 2.915E-16 3.064E-15 1.312E-14 23 245
46 C103505 AM 251 CTD 8.815E-19 3.942E-16 4.142E-15 1.813E-14 17 99
47 3518 UP Pyrvinium pamoate [3546-41-6]; Up 200; 3.4uM; MCF7; HT HG-U133A Broad Institute CMAP 9.807E-19 4.292E-16 4.510E-15 2.017E-14 20 166
48 4835 UP Nifuroxazide [965-52-6]; Up 200; 14.6uM; MCF7; HT HG-U133A Broad Institute CMAP 1.090E-18 4.669E-16 4.906E-15 2.241E-14 21 193
49 4454 UP thioridazine hydrochloride; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 1.249E-18 5.243E-16 5.509E-15 2.569E-14 20 168
50 941 UP rottlerin; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.585E-18 6.394E-16 6.720E-15 3.261E-14 20 170
Show 45 more annotations

18: Disease [Display Chart] 2389 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0856169 Endothelial dysfunction DisGeNET BeFree 2.549E-5 2.695E-2
2.252E-1
6.089E-2
 10 216
2 umls:C0007959 Charcot-Marie-Tooth Disease DisGeNET Curated 6.255E-5 2.695E-2
2.252E-1
1.494E-1
 8 150
3 cv:C1840548 Susceptibility to severe cutaneous adverse reaction Clinical Variations 8.006E-5 2.695E-2
2.252E-1
1.913E-1
 2 2
4 106300 SPONDYLOARTHROPATHY, SUSCEPTIBILITY TO, 1; SPDA1 OMIM 8.006E-5 2.695E-2
2.252E-1
1.913E-1
 2 2
5 608579 SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO OMIM 8.006E-5 2.695E-2
2.252E-1
1.913E-1
 2 2
6 umls:C0265218 Neu-Laxova syndrome DisGeNET Curated 8.006E-5 2.695E-2
2.252E-1
1.913E-1
 2 2
7 umls:C0023896 Alcoholic Liver Diseases DisGeNET Curated 8.218E-5 2.695E-2
2.252E-1
1.963E-1
 6 80
8 umls:C0151744 Myocardial Ischemia DisGeNET Curated 9.025E-5 2.695E-2
2.252E-1
2.156E-1
 13 413
9 umls:C0038012 Spondylitis DisGeNET BeFree 1.110E-4 2.810E-2
2.348E-1
2.651E-1
 3 11
10 umls:C0011616 Contact Dermatitis DisGeNET Curated 1.230E-4 2.810E-2
2.348E-1
2.939E-1
 6 86
11 umls:C0032580 Adenomatous Polyposis Coli DisGeNET Curated 1.316E-4 2.810E-2
2.348E-1
3.145E-1
 12 371
12 umls:C0345967 Malignant mesothelioma DisGeNET Curated 1.411E-4 2.810E-2
2.348E-1
3.372E-1
 10 265
13 umls:C0002940 Aneurysm DisGeNET Curated 2.162E-4 3.140E-2
2.624E-1
5.165E-1
 7 135
14 umls:C0007115 Malignant neoplasm of thyroid DisGeNET BeFree 2.248E-4 3.140E-2
2.624E-1
5.371E-1
 13 453
15 umls:C0001175 Acquired Immunodeficiency Syndrome DisGeNET Curated 2.254E-4 3.140E-2
2.624E-1
5.386E-1
 6 96
16 umls:C0034642 Rales DisGeNET BeFree 2.388E-4 3.140E-2
2.624E-1
5.704E-1
 2 3
17 umls:C0235270 Keratopathy DisGeNET BeFree 2.388E-4 3.140E-2
2.624E-1
5.704E-1
 2 3
18 umls:C0010691 Cystinuria DisGeNET Curated 2.400E-4 3.140E-2
2.624E-1
5.733E-1
 3 14
19 umls:C0598608 Hyperhomocysteinemia DisGeNET Curated 2.523E-4 3.140E-2
2.624E-1
6.026E-1
 6 98
20 umls:C0340643 Dissection of aorta DisGeNET BeFree 2.629E-4 3.140E-2
2.624E-1
6.281E-1
 4 35
21 umls:C0042373 Vascular Diseases DisGeNET Curated 2.924E-4 3.327E-2
2.780E-1
6.986E-1
 11 346
22 umls:C0566602 Primary sclerosing cholangitis DisGeNET Curated 4.262E-4 3.859E-2
3.225E-1
1.000E0
 6 108
23 umls:C0008313 Cholangitis, Sclerosing DisGeNET Curated 4.404E-4 3.859E-2
3.225E-1
1.000E0
 5 71
24 umls:C0041327 Tuberculosis, Pulmonary DisGeNET Curated 4.504E-4 3.859E-2
3.225E-1
1.000E0
 8 200
25 umls:C0024115 Lung diseases DisGeNET Curated 4.576E-4 3.859E-2
3.225E-1
1.000E0
 10 307
26 umls:C0878631 pathergy DisGeNET BeFree 4.747E-4 3.859E-2
3.225E-1
1.000E0
 2 4
27 umls:C0042167 Uveitis, Posterior DisGeNET BeFree 4.747E-4 3.859E-2
3.225E-1
1.000E0
 2 4
28 umls:C0175708 Chronic rheumatic heart disease DisGeNET BeFree 4.747E-4 3.859E-2
3.225E-1
1.000E0
 2 4
29 20090227:Garcia-Barcelo Hirschsprung's disease GWAS 4.747E-4 3.859E-2
3.225E-1
1.000E0
 2 4
30 umls:C0023484 Leukemia, Plasma Cell DisGeNET BeFree 4.877E-4 3.859E-2
3.225E-1
1.000E0
 4 41
31 umls:C3495426 Homocysteinemia DisGeNET BeFree 5.008E-4 3.859E-2
3.225E-1
1.000E0
 5 73
32 umls:C1959632 Plasma Cell Neoplasm DisGeNET BeFree 5.240E-4 3.912E-2
3.269E-1
1.000E0
 3 18
33 umls:C1269683 Major Depressive Disorder DisGeNET Curated 5.714E-4 4.074E-2
3.404E-1
1.000E0
 12 436
34 umls:C0409651 Seropositive rheumatoid arthritis DisGeNET BeFree 6.182E-4 4.074E-2
3.404E-1
1.000E0
 3 19
35 umls:C0026636 Mouth Diseases DisGeNET Curated 6.182E-4 4.074E-2
3.404E-1
1.000E0
 3 19
36 umls:C0494463 Alzheimer Disease, Late Onset DisGeNET BeFree 6.401E-4 4.074E-2
3.404E-1
1.000E0
 5 77
37 umls:C1519670 Tumor Angiogenesis DisGeNET BeFree 6.574E-4 4.074E-2
3.404E-1
1.000E0
 12 443
38 umls:C1800706 Idiopathic Pulmonary Fibrosis DisGeNET Curated 6.786E-4 4.074E-2
3.404E-1
1.000E0
 10 323
39 umls:C0151514 Atrophic condition of skin DisGeNET BeFree 6.821E-4 4.074E-2
3.404E-1
1.000E0
 6 118
40 umls:C1292753 Primary Effusion Lymphoma DisGeNET BeFree 6.821E-4 4.074E-2
3.404E-1
1.000E0
 6 118
41 umls:C0035078 Kidney Failure DisGeNET BeFree 7.116E-4 4.146E-2
3.465E-1
1.000E0
 10 325
42 umls:C0398701 Immunoglobulin G2 deficiency DisGeNET BeFree 7.865E-4 4.370E-2
3.651E-1
1.000E0
 2 5
43 umls:C0026961 Mydriasis DisGeNET BeFree 7.865E-4 4.370E-2
3.651E-1
1.000E0
 2 5
44 umls:C1328504 Hormone refractory prostate cancer DisGeNET BeFree 8.067E-4 4.380E-2
3.660E-1
1.000E0
 5 81
45 umls:C0263361 Psoriasis vulgaris DisGeNET BeFree 8.847E-4 4.680E-2
3.911E-1
1.000E0
 6 124
46 umls:C0920646 Renal ischaemia DisGeNET BeFree 9.011E-4 4.680E-2
3.911E-1
1.000E0
 5 83
47 umls:C0206701 Cystadenocarcinoma, Serous DisGeNET BeFree 9.513E-4 4.765E-2
3.981E-1
1.000E0
 5 84
48 umls:C0338656 Impaired cognition DisGeNET Curated 9.573E-4 4.765E-2
3.981E-1
1.000E0
 11 399
Show 43 more annotations