Toppgene analysis for aggregated_1964_log, IC7, negative side

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1: GO: Molecular Function [Display Chart] 319 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0055131 C3HC4-type RING finger domain binding 1.588E-4 3.539E-2
2.245E-1
5.067E-2
2 6
2 GO:0016936 galactoside binding 2.219E-4 3.539E-2
2.245E-1
7.079E-2
2 7
3 GO:0031072 heat shock protein binding 4.127E-4 4.388E-2
2.784E-1
1.316E-1
4 106

2: GO: Biological Process [Display Chart] 2068 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0044706 multi-multicellular organism process 2.047E-6 4.207E-3 3.455E-2 4.233E-3 8 250
2 GO:0010038 response to metal ion 4.104E-6 4.207E-3 3.455E-2 8.488E-3 9 368
3 GO:0090084 negative regulation of inclusion body assembly 6.103E-6 4.207E-3 3.455E-2 1.262E-2 3 11
4 GO:0007565 female pregnancy 8.855E-6 4.578E-3 3.759E-2 1.831E-2 7 217
5 GO:0045105 intermediate filament polymerization or depolymerization 3.420E-5 9.087E-3
7.462E-2
7.074E-2
2 3
6 GO:0033693 neurofilament bundle assembly 3.420E-5 9.087E-3
7.462E-2
7.074E-2
2 3
7 GO:0051591 response to cAMP 3.483E-5 9.087E-3
7.462E-2
7.202E-2
5 109
8 GO:0090083 regulation of inclusion body assembly 3.515E-5 9.087E-3
7.462E-2
7.269E-2
3 19
9 GO:0031960 response to corticosteroid 4.557E-5 9.414E-3
7.731E-2
9.424E-2
6 190
10 GO:0042026 protein refolding 6.362E-5 9.414E-3
7.731E-2
1.316E-1
3 23
11 GO:0002761 regulation of myeloid leukocyte differentiation 6.454E-5 9.414E-3
7.731E-2
1.335E-1
5 124
12 GO:0070370 cellular heat acclimation 6.826E-5 9.414E-3
7.731E-2
1.412E-1
2 4
13 GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway 6.826E-5 9.414E-3
7.731E-2
1.412E-1
2 4
14 GO:0070426 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway 6.826E-5 9.414E-3
7.731E-2
1.412E-1
2 4
15 GO:0001503 ossification 6.828E-5 9.414E-3
7.731E-2
1.412E-1
8 406
16 GO:0070841 inclusion body assembly 8.222E-5 1.063E-2
8.727E-2
1.700E-1
3 25
17 GO:0051961 negative regulation of nervous system development 8.822E-5 1.073E-2
8.813E-2
1.824E-1
7 311
18 GO:0051412 response to corticosterone 1.041E-4 1.145E-2
9.402E-2
2.152E-1
3 27
19 GO:0045670 regulation of osteoclast differentiation 1.118E-4 1.145E-2
9.402E-2
2.312E-1
4 73
20 GO:0010286 heat acclimation 1.135E-4 1.145E-2
9.402E-2
2.347E-1
2 5
21 GO:0045671 negative regulation of osteoclast differentiation 1.163E-4 1.145E-2
9.402E-2
2.404E-1
3 28
22 GO:0046683 response to organophosphorus 1.396E-4 1.312E-2
1.078E-1
2.887E-1
5 146
23 GO:0031133 regulation of axon diameter 1.699E-4 1.405E-2
1.154E-1
3.513E-1
2 6
24 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway 1.699E-4 1.405E-2
1.154E-1
3.513E-1
2 6
25 GO:0045110 intermediate filament bundle assembly 1.699E-4 1.405E-2
1.154E-1
3.513E-1
2 6
26 GO:0070432 regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway 2.373E-4 1.818E-2
1.493E-1
4.908E-1
2 7
27 GO:1904338 regulation of dopaminergic neuron differentiation 2.373E-4 1.818E-2
1.493E-1
4.908E-1
2 7
28 GO:0051385 response to mineralocorticoid 2.485E-4 1.835E-2
1.507E-1
5.139E-1
3 36
29 GO:0051402 neuron apoptotic process 2.703E-4 1.885E-2
1.548E-1
5.589E-1
6 263
30 GO:1902106 negative regulation of leukocyte differentiation 2.734E-4 1.885E-2
1.548E-1
5.655E-1
4 92
31 GO:0014074 response to purine-containing compound 2.912E-4 1.943E-2
1.595E-1
6.023E-1
5 171
32 GO:0048709 oligodendrocyte differentiation 3.092E-4 1.998E-2
1.641E-1
6.394E-1
4 95
33 GO:0051384 response to glucocorticoid 3.414E-4 2.139E-2
1.757E-1
7.060E-1
5 177
34 GO:0030316 osteoclast differentiation 3.905E-4 2.295E-2
1.884E-1
8.076E-1
4 101
35 GO:0042063 gliogenesis 3.921E-4 2.295E-2
1.884E-1
8.109E-1
6 282
36 GO:0097305 response to alcohol 3.994E-4 2.295E-2
1.884E-1
8.260E-1
7 398
37 GO:0007519 skeletal muscle tissue development 4.953E-4 2.612E-2
2.145E-1
1.000E0
5 192
38 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway 5.052E-4 2.612E-2
2.145E-1
1.000E0
2 10
39 GO:0060052 neurofilament cytoskeleton organization 5.052E-4 2.612E-2
2.145E-1
1.000E0
2 10
40 GO:0060174 limb bud formation 5.052E-4 2.612E-2
2.145E-1
1.000E0
2 10
41 GO:0060537 muscle tissue development 5.428E-4 2.687E-2
2.206E-1
1.000E0
7 419
42 GO:0002683 negative regulation of immune system process 5.824E-4 2.687E-2
2.206E-1
1.000E0
7 424
43 GO:1901654 response to ketone 6.098E-4 2.687E-2
2.206E-1
1.000E0
5 201
44 GO:0014013 regulation of gliogenesis 6.175E-4 2.687E-2
2.206E-1
1.000E0
4 114
45 GO:0031103 axon regeneration 6.214E-4 2.687E-2
2.206E-1
1.000E0
3 49
46 GO:0002762 negative regulation of myeloid leukocyte differentiation 6.214E-4 2.687E-2
2.206E-1
1.000E0
3 49
47 GO:0031099 regeneration 6.236E-4 2.687E-2
2.206E-1
1.000E0
5 202
48 GO:0060538 skeletal muscle organ development 6.236E-4 2.687E-2
2.206E-1
1.000E0
5 202
49 GO:0045637 regulation of myeloid cell differentiation 6.814E-4 2.876E-2
2.362E-1
1.000E0
5 206
50 GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 7.377E-4 3.051E-2
2.506E-1
1.000E0
2 12
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 166 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005814 centriole 4.193E-4 4.027E-2
2.292E-1
6.960E-2
4 105
2 GO:0005883 neurofilament 4.852E-4 4.027E-2
2.292E-1
8.054E-2
2 10

4: Human Phenotype [Display Chart] 179 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000083 Renal insufficiency 1.453E-3 3.721E-2
2.146E-1
2.601E-1
3 96
2 HP:0003621 Juvenile onset 2.153E-3 3.721E-2
2.146E-1
3.854E-1
3 110
3 HP:0007233 Clusters of axonal regeneration 2.494E-3 3.721E-2
2.146E-1
4.465E-1
1 1
4 HP:0006390 Anterior tibial bowing 2.494E-3 3.721E-2
2.146E-1
4.465E-1
1 1
5 HP:0005035 Shortening of all phalanges of the toes 2.494E-3 3.721E-2
2.146E-1
4.465E-1
1 1
6 HP:0001785 Ankle swelling {has synonym type="layperson"} 2.494E-3 3.721E-2
2.146E-1
4.465E-1
1 1
7 HP:0008477 Poorly ossified cervical vertebrae 2.494E-3 3.721E-2
2.146E-1
4.465E-1
1 1
8 HP:0009929 Abnormality of the columella 2.494E-3 3.721E-2
2.146E-1
4.465E-1
1 1
9 HP:0006536 Obstructive lung disease {has synonym type="layperson"} 2.494E-3 3.721E-2
2.146E-1
4.465E-1
1 1
10 HP:0011910 Shortening of all phalanges of fingers 2.494E-3 3.721E-2
2.146E-1
4.465E-1
1 1
11 HP:0012702 Tenesmus 2.494E-3 3.721E-2
2.146E-1
4.465E-1
1 1
12 HP:0011937 Hypoplastic fifth toenail 2.494E-3 3.721E-2
2.146E-1
4.465E-1
1 1
13 HP:0012745 Short palpebral fissure 4.613E-3 4.460E-2
2.572E-1
8.257E-1
2 42
14 HP:0003394 Muscle cramps 4.831E-3 4.460E-2
2.572E-1
8.648E-1
2 43
15 HP:0006234 Osteolysis involving tarsal bones 4.983E-3 4.460E-2
2.572E-1
8.920E-1
1 2
16 HP:0001473 Metatarsal osteolysis 4.983E-3 4.460E-2
2.572E-1
8.920E-1
1 2
17 HP:0001504 Metacarpal osteolysis 4.983E-3 4.460E-2
2.572E-1
8.920E-1
1 2
18 HP:0007166 Paroxysmal dyskinesia 4.983E-3 4.460E-2
2.572E-1
8.920E-1
1 2
19 HP:0001225 Wrist swelling {has synonym type="layperson"} 4.983E-3 4.460E-2
2.572E-1
8.920E-1
1 2
20 HP:0001495 Carpal osteolysis 4.983E-3 4.460E-2
2.572E-1
8.920E-1
1 2
Show 15 more annotations

5: Mouse Phenotype [Display Chart] 1618 annotations before applied cutoff / 9299 genes in category

No results to display

6: Domain [Display Chart] 408 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF01023 S 100 Pfam 2.048E-6 1.945E-4 1.282E-3 8.358E-4 4 27
2 PS00303 S100 CABP PROSITE 2.048E-6 1.945E-4 1.282E-3 8.358E-4 4 27
3 SM01394 S 100 SMART 2.384E-6 1.945E-4 1.282E-3 9.726E-4 4 28
4 IPR013787 S100 Ca-bd sub InterPro 2.384E-6 1.945E-4 1.282E-3 9.726E-4 4 28
5 IPR001751 S100/CaBP-9k CS InterPro 2.384E-6 1.945E-4 1.282E-3 9.726E-4 4 28
6 IPR006821 Intermed filament DNA-bd InterPro 2.386E-4 1.387E-2
9.138E-2
9.735E-2
2 7
7 PF04732 Filament head Pfam 2.386E-4 1.387E-2
9.138E-2
9.735E-2
2 7
8 IPR008917 TF DNA-bd InterPro 2.719E-4 1.387E-2
9.138E-2
1.109E-1
3 37
9 IPR000837 AP-1 InterPro 4.072E-4 1.846E-2
1.217E-1
1.661E-1
2 9
10 SM00338 BRLZ SMART 7.456E-4 2.020E-2
1.331E-1
3.042E-1
3 52
11 PS50217 BZIP PROSITE 7.885E-4 2.020E-2
1.331E-1
3.217E-1
3 53
12 PS00036 BZIP BASIC PROSITE 7.885E-4 2.020E-2
1.331E-1
3.217E-1
3 53
13 IPR004827 bZIP InterPro 8.328E-4 2.020E-2
1.331E-1
3.398E-1
3 54
14 PF00012 HSP70 Pfam 1.337E-3 2.020E-2
1.331E-1
5.453E-1
2 16
15 PF07716 bZIP 2 Pfam 1.512E-3 2.020E-2
1.331E-1
6.167E-1
2 17
16 PS00297 HSP70 1 PROSITE 1.512E-3 2.020E-2
1.331E-1
6.167E-1
2 17
17 PS01036 HSP70 3 PROSITE 1.512E-3 2.020E-2
1.331E-1
6.167E-1
2 17
18 PS00329 HSP70 2 PROSITE 1.512E-3 2.020E-2
1.331E-1
6.167E-1
2 17
19 IPR013126 Hsp 70 fam InterPro 1.697E-3 2.020E-2
1.331E-1
6.923E-1
2 18
20 IPR024066 RGS subdom1 InterPro 2.539E-3 2.020E-2
1.331E-1
1.000E0
2 22
21 1.10.196.10 - Gene3D 2.539E-3 2.020E-2
1.331E-1
1.000E0
2 22
22 IPR027006 SYTL2 InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
23 PD019364 PD019364 ProDom 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
24 PF11931 DUF3449 Pfam 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
25 PS00884 OSTEOPONTIN PROSITE 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
26 PS00412 NEUROMODULIN 1 PROSITE 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
27 IPR022330 TNFR 21 InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
28 PF16837 SF3A3 Pfam 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
29 IPR027697 NF-M InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
30 IPR018243 Neuromodulin palmitoyl site InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
31 IPR020633 Thymidine kinase CS InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
32 IPR012213 IGFBP-5 InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
33 IPR030562 ENC1 InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
34 PS51275 PEPTIDASE C26 GGH PROSITE 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
35 IPR031774 SF3A3 dom InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
36 PF10580 Neuromodulin N Pfam 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
37 PF07722 Peptidase C26 Pfam 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
38 SM00017 OSTEO SMART 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
39 IPR031776 SF3A3 InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
40 IPR018947 Neuromodulin gap-junction N InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
41 IPR019841 Osteopontin CS InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
42 IPR028476 S100-A10 InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
43 IPR028487 S100A13 InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
44 IPR021966 SF3a60 bindingd InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
45 IPR001422 Neuromodulin InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
46 IPR026778 MLLT11 fam InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
47 IPR033360 TIAM1 InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
48 PF11092 Alveol-reg P311 Pfam 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
49 IPR024417 Neuronal 3.1 InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
50 IPR017454 Neuromodulin C InterPro 3.416E-3 2.020E-2
1.331E-1
1.000E0
1 1
Show 45 more annotations

7: Pathway [Display Chart] 489 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 137939 Direct p53 effectors BioSystems: Pathway Interaction Database 6.149E-8 3.007E-5 2.036E-4 3.007E-5 8 134
2 137935 FOXM1 transcription factor network BioSystems: Pathway Interaction Database 1.865E-5 4.561E-3 3.088E-2 9.122E-3 4 39
3 138045 HIF-1-alpha transcription factor network BioSystems: Pathway Interaction Database 1.420E-4 2.315E-2
1.567E-1
6.945E-2
4 65
4 169351 Validated targets of C-MYC transcriptional activation BioSystems: Pathway Interaction Database 3.326E-4 4.067E-2
2.753E-1
1.627E-1
4 81
5 198759 Myometrial Relaxation and Contraction Pathways BioSystems: WikiPathways 4.181E-4 4.089E-2
2.769E-1
2.045E-1
5 155

8: Pubmed [Display Chart] 11639 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20628624:gr Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". GeneRIF 4.700E-11 2.735E-7 2.719E-6 5.470E-7 8 172
2 20628624 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". Pubmed 4.700E-11 2.735E-7 2.719E-6 5.470E-7 8 172
3 14741347 Placental growth factor induces FosB and c-Fos gene expression via Flt-1 receptors. Pubmed 7.166E-9 2.085E-5 2.073E-4 8.341E-5 3 4
4 14741347:gr Placental growth factor induces FosB and c-Fos gene expression via Flt-1 receptors. GeneRIF 7.166E-9 2.085E-5 2.073E-4 8.341E-5 3 4
5 21763498 Reciprocal regulation of human immunodeficiency virus-1 gene expression and replication by heat shock proteins 40 and 70. Pubmed 1.498E-7 2.424E-4 2.409E-3 1.744E-3 3 9
6 23921388 Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. Pubmed 2.139E-7 2.424E-4 2.409E-3 2.489E-3 3 10
7 25241761 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. Pubmed 3.969E-7 2.424E-4 2.409E-3 4.620E-3 7 371
8 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 4.912E-7 2.424E-4 2.409E-3 5.717E-3 7 383
9 19453261:gr High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. GeneRIF 4.912E-7 2.424E-4 2.409E-3 5.717E-3 7 383
10 12150907 CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Pubmed 5.083E-7 2.424E-4 2.409E-3 5.916E-3 3 13
11 7759097 Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. Pubmed 9.927E-7 2.424E-4 2.409E-3 1.155E-2 3 16
12 10216320 Structure of a new crystal form of human Hsp70 ATPase domain. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
13 11356186 Identification of an interaction between SOX9 and HSP70. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
14 1478667 Syntenic conservation of HSP70 genes in cattle and humans. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
15 10593983 Heat shock protein (Hsp) 40 mutants inhibit Hsp70 in mammalian cells. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
16 16735677:gr Deletion of the inducible 70-kDa heat shock protein genes in mice impairs cardiac contractile function and calcium handling associated with hypertrophy. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
17 20235222:gr Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
18 3786141 In vitro transcription of a human hsp 70 heat shock gene by extracts prepared from heat-shocked and non-heat-shocked human cells. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
19 16679378:gr Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
20 12133495 [Detection of level and mutation of neurofilament mRNA in Alzheimer's disease]. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
21 15748471:gr [Relationship between heat stress protein 70 gene polymorphisms and the risk of acute mountain sickness]. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
22 3931075 Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
23 17364813 Sequence analysis of HSPA1A and HSPA1B in a multi-ethnic study population. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
24 12714332:gr HSP70.1 and -70.3 are required for late-phase protection induced by ischemic preconditioning of mouse hearts. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
25 15498567:gr Role of the C-terminal region of mouse inducible Hsp72 in the recognition of peptide substrate for chaperone activity. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
26 12376177:gr FOS and FOSB expression in the medial preoptic nucleus pars compacta of maternally active C57BL/6J and DBA/2J mice. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
27 17482577:gr Geranylgeranylaceton induces heat shock protein 72 in skeletal muscle cells. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
28 16804002:gr Heat-shock protein 70 genes and human longevity: a view from Denmark. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
29 17126904:gr Functional region of mouse heat shock protein 72 for its binding to lymphoid neoplastic P388D1 cells. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
30 20876613:gr Genetic determinants of HSP70 gene expression following heat shock. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
31 15719414:gr Hippocampal 72-kDa heat shock protein expression varies according to mice learning performance independently from chronic exposure to stress. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
32 21757701:gr Coordinated post-transcriptional regulation of Hsp70.3 gene expression by microRNA and alternative polyadenylation. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
33 15232679:gr The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
34 21094186:gr Biological activity of truncated C-terminus human heat shock protein 72. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
35 14672969:gr Effects of voluntary exercise and genetic selection for high activity levels on HSP72 expression in house mice. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
36 20876613 Genetic determinants of HSP70 gene expression following heat shock. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
37 21970979 Human immunodeficiency virus-1 Nef suppresses Hsp70-mediated Tat activation. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
38 12411538 Exercise induces hepatosplanchnic release of heat shock protein 72 in humans. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
39 16971451:gr hsp72, a host determinant of measles virus neurovirulence. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
40 15926923:gr Forebrain patterns of c-Fos and FosB induction during cancer-associated anorexia-cachexia in rat. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
41 11864979 Effect of hyaluronan oligosaccharides on the expression of heat shock protein 72. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
42 15926923 Forebrain patterns of c-Fos and FosB induction during cancer-associated anorexia-cachexia in rat. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
43 16804002 Heat-shock protein 70 genes and human longevity: a view from Denmark. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
44 12207910:gr IL-6 activates HSP72 gene expression in human skeletal muscle. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
45 3019832 Molecular cloning of sequences encoding the human heat-shock proteins and their expression during hyperthermia. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
46 22940431:gr Effects of heat shock protein 72 (Hsp72) on evolution of astrocyte activation following stroke in the mouse. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
47 15748471 [Relationship between heat stress protein 70 gene polymorphisms and the risk of acute mountain sickness]. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
48 25271869 Decreased dickkopf-1 levels in chronic lymphocytic leukemia and increased osteopontin levels in non-Hodgkin's lymphoma at initial diagnosis: Could they be playing roles in pathogenesis? Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
49 11864979:gr Effect of hyaluronan oligosaccharides on the expression of heat shock protein 72. GeneRIF 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
50 24328534 Up-regulation of inducible heat shock protein-70 expression in multiple sclerosis patients. Pubmed 1.500E-6 2.424E-4 2.409E-3 1.745E-2 2 2
Show 45 more annotations

9: Interaction [Display Chart] 1699 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:NEFH NEFH interactions 4.016E-5 2.908E-2
2.331E-1
6.823E-2
3 19
2 int:GLB1 GLB1 interactions 4.712E-5 2.908E-2
2.331E-1
8.006E-2
3 20
3 int:KCNMA1 KCNMA1 interactions 5.135E-5 2.908E-2
2.331E-1
8.725E-2
6 186
4 int:METTL7B METTL7B interactions 7.477E-5 3.176E-2
2.545E-1
1.270E-1
2 4
5 int:MAF MAF interactions 9.388E-5 3.190E-2
2.557E-1
1.595E-1
3 25
6 int:NQO1 NQO1 interactions 1.188E-4 3.363E-2
2.696E-1
2.018E-1
3 27
7 int:NEFM NEFM interactions 1.636E-4 3.838E-2
3.076E-1
2.780E-1
3 30
8 int:HMGN1 HMGN1 interactions 1.807E-4 3.838E-2
3.076E-1
3.070E-1
3 31
Show 3 more annotations

10: Cytoband [Display Chart] 56 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1q21 1q21 8.392E-7 4.699E-5 2.167E-4 4.699E-5 5 93
2 2p25 2p25 5.038E-4 1.165E-2
5.373E-2
2.821E-2 2 18
3 8p21 8p21 6.241E-4 1.165E-2
5.373E-2
3.495E-2 2 20
4 17q23.2-q25.3 17q23.2-q25.3 1.846E-3 2.068E-2
9.537E-2
1.034E-1
1 1
5 5q12.1-q13.2 5q12.1-q13.2 1.846E-3 2.068E-2
9.537E-2
1.034E-1
1 1
6 20q11.2-q13.1 20q11.2-q13.1 3.690E-3 2.583E-2
1.191E-1
2.066E-1
1 2
7 Xq21.33-q22.3 Xq21.33-q22.3 3.690E-3 2.583E-2
1.191E-1
2.066E-1
1 2
8 3q13.1-q13.2 3q13.1-q13.2 3.690E-3 2.583E-2
1.191E-1
2.066E-1
1 2
9 8p21-p11.2 8p21-p11.2 5.529E-3 2.815E-2
1.298E-1
3.096E-1
1 3
10 2q33-q36 2q33-q36 5.529E-3 2.815E-2
1.298E-1
3.096E-1
1 3
11 3q21-q25 3q21-q25 5.529E-3 2.815E-2
1.298E-1
3.096E-1
1 3
Show 6 more annotations

11: Transcription Factor Binding Site [Display Chart] 358 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 41 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 459 S100 calcium binding proteins|EF-hand domain containing genenames.org 1.427E-7 5.849E-6 2.517E-5 5.849E-6 4 21
2 1256 Basic leucine zipper proteins|Fos transcription factor family genenames.org 3.112E-5 6.380E-4 2.745E-3 1.276E-3 2 4
3 611 Intermediate filaments Type IV|Protein phosphatase 1 regulatory subunits genenames.org 7.758E-5 1.060E-3 4.562E-3 3.181E-3 2 6
4 506 Basic leucine zipper proteins genenames.org 1.957E-4 2.006E-3 8.633E-3 8.025E-3 3 49
5 583 Heat shock 70kDa proteins genenames.org 6.921E-4 5.676E-3 2.442E-2 2.838E-2 2 17
6 757 SRY-boxes genenames.org 8.677E-4 5.929E-3 2.551E-2 3.558E-2 2 19
7 720 Endogenous ligands|Regulators of G-protein signaling genenames.org 1.063E-3 6.223E-3 2.678E-2 4.356E-2 2 21
8 694 Protein phosphatase 1 regulatory subunits|BCL2 family genenames.org 8.363E-3 3.765E-2
1.620E-1
3.429E-1
3 181
9 1338 Baculoviral IAP repeat containing|Chromosomal passenger complex genenames.org 9.203E-3 3.765E-2
1.620E-1
3.773E-1
1 4
10 1324 STEAP family genenames.org 1.149E-2 3.765E-2
1.620E-1
4.711E-1
1 5
11 1267 VEGF family genenames.org 1.149E-2 3.765E-2
1.620E-1
4.711E-1
1 5
12 1279 Deafness associated genes|SIBLING family genenames.org 1.149E-2 3.765E-2
1.620E-1
4.711E-1
1 5
13 255 Potassium calcium-activated channels genenames.org 1.377E-2 3.765E-2
1.620E-1
5.647E-1
1 6
14 1065 Insulin like growth factor binding proteins genenames.org 1.377E-2 3.765E-2
1.620E-1
5.647E-1
1 6
15 1309 BTG/Tob family genenames.org 1.377E-2 3.765E-2
1.620E-1
5.647E-1
1 6
16 742 Shisa family members genenames.org 1.832E-2 4.419E-2
1.901E-1
7.512E-1
1 8
17 419 Baculoviral IAP repeat containing|Chromosomal passenger complex genenames.org 1.832E-2 4.419E-2
1.901E-1
7.512E-1
1 8
Show 12 more annotations

13: Coexpression [Display Chart] 4737 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2726 Genes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] MCF-7 cells (breast cancer) stably over-expressing constitutively active RAF1 [Gene ID=5894] gene. MSigDB C6: Oncogenic Signatures (v5.1) 9.951E-12 4.714E-8 4.262E-7 4.714E-8 11 194
2 M10508 Genes known to be induced by hypoxia MSigDB C2: CGP Curated Gene Sets (v5.1) 9.308E-11 1.721E-7 1.555E-6 4.409E-7 8 81
3 M2293 Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.090E-10 1.721E-7 1.555E-6 5.162E-7 12 315
4 GSE37301 HEMATOPOIETIC STEM CELL VS RAG2 KO NK CELL DN Genes down-regulated in hematopoietic stem cells versus NK cells with RAG2 [GeneID=5897] knockout. MSigDB C7: Immunologic Signatures (v5.1) 2.649E-9 3.138E-6 2.837E-5 1.255E-5 9 180
5 M15981 Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.742E-9 3.545E-6 3.205E-5 1.772E-5 12 430
6 M1597 Cluster 2: genes maximally expressed at 2 h time point during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) in response to adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.032E-9 6.159E-6 5.568E-5 3.805E-5 6 51
7 M4780 Genes down-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.101E-9 6.159E-6 5.568E-5 4.311E-5 11 369
8 M1459 Genes up-regulated in BEC (blood endothelial cells) compared to LEC (lymphatic endothelial cells). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.374E-8 1.298E-5 1.173E-4 1.125E-4 8 162
9 M2700 Genes down-regulated in bone relapse of breast cancer. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.465E-8 1.298E-5 1.173E-4 1.168E-4 10 314
10 M14072 Genes regulated by hypoxia, based on literature searches. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.481E-8 1.546E-5 1.398E-4 1.649E-4 9 242
11 M7363 Genes up-regulated in MCF7 cells (breast cancer) under hypoxia conditions. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.618E-8 1.546E-5 1.398E-4 1.714E-4 8 171
12 M1417 Genes down-regulated during epithelial to mesenchymal transition (EMT) induced by TGFB1 [GeneID=7040] in the EpH4 cells (mammary epithelium cell line transformed by HRAS [GeneID=3265]). MSigDB C2: CGP Curated Gene Sets (v5.1) 3.916E-8 1.546E-5 1.398E-4 1.855E-4 6 66
13 M5681 Genes up-regulated in apoptotic tissues (neuroepithelium) after MDM4 [GeneID=4194] knockout. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.527E-8 1.649E-5 1.491E-4 2.144E-4 8 176
14 M2879 Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.502E-8 1.862E-5 1.683E-4 2.606E-4 10 342
15 M3645 Genes up-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.902E-8 1.864E-5 1.685E-4 2.796E-4 11 443
16 M12338 Genes changed in NIH 3T3 cells (embryonic fibroblast) by expression of one or more of C/EBP proteins: CEBPA, CEBPB, CEBPG, and CEBPD [GeneID=1050;1051;1054;1052]. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.433E-8 2.460E-5 2.224E-4 3.995E-4 7 126
17 M14127 Genes up-regulated in multiple myeloma (MM) cell lines treated with both decitabine [PubChem=451668] TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.827E-8 2.460E-5 2.224E-4 4.181E-4 11 461
18 M4306 Genes down-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.423E-8 2.480E-5 2.242E-4 4.464E-4 11 464
19 M9197 Genes up-regulated in MCF7 cells (breast cancer) treated with hypoxia mimetic DMOG [PubChem=3080614]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.046E-7 2.607E-5 2.357E-4 4.953E-4 7 130
20 M3013 Genes down-regulated in comparison of naive versus effector CD8 T cells at the peak expansion phase (day8 after LCMV-Armstrong infection). MSigDB C7: Immunologic Signatures (v5.1) 1.215E-7 2.741E-5 2.478E-4 5.756E-4 8 200
21 M5924 Genes up-regulated through activation of mTORC1 complex. MSigDB H: Hallmark Gene Sets (v5.1) 1.215E-7 2.741E-5 2.478E-4 5.756E-4 8 200
22 M1914 Genes up-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.779E-7 3.830E-5 3.463E-4 8.427E-4 9 293
23 M2506 Genes up-regulated in the neural crest stem cells (NCS), defined as p75+/HNK1+ [GeneID=4804;27087]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.313E-7 4.765E-5 4.308E-4 1.096E-3 7 146
24 GSE36891 UNSTIM VS POLYIC TLR3 STIM PERITONEAL MACROPHAGE UP Genes up-regulated in peritoneal macrophages: untreated versus poly(IC). MSigDB C7: Immunologic Signatures (v5.1) 2.424E-7 4.784E-5 4.325E-4 1.148E-3 7 147
25 M19467 Genes down-regulated in five primary endothelial cell types (lung, aortic, iliac, dermal, and colon) by TNF [GeneID=7124]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.541E-7 4.815E-5 4.353E-4 1.204E-3 6 90
26 M10279 Genes down-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [GeneID=9589] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.863E-7 5.216E-5 4.715E-4 1.356E-3 9 310
27 M2256 Genes commonly down-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313 ,2078]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.200E-7 5.615E-5 5.076E-4 1.516E-3 8 227
28 M863 Myb-regulated genes in MCF7 (breast cancer) and lung epithelial cell lines overexpressing MYBL2, MYBL1 or MYB [GeneID=4605;4603;4602]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.546E-7 5.999E-5 5.424E-4 1.680E-3 9 318
29 M4716 Genes up-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402], a protease inhibitor causing apoptosis. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.732E-7 7.729E-5 6.987E-4 2.241E-3 8 239
30 M6189 Genes down-regulated in MCF7 cells (breast cancer) after knockdown of both HIF1A and HIF2A [GeneID=3091;2034] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.999E-7 9.472E-5 8.563E-4 2.841E-3 6 104
31 M16108 Genes down-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402], a protease inhibitor causing apoptosis. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.021E-7 1.073E-4 9.699E-4 3.326E-3 7 172
32 M19768 Genes downregulated in MCF10A cells (breast cancer) co-cultured with cancer-associated fibroblasts (CAF). MSigDB C2: CGP Curated Gene Sets (v5.1) 7.496E-7 1.110E-4 1.003E-3 3.551E-3 6 108
33 GSE15330 LYMPHOID MULTIPOTENT VS MEGAKARYOCYTE ERYTHROID PROGENITOR IKAROS KO DN Genes down-regulated in IKZF1 [GeneID=10320] knockout: lymphoid-primed multipotent progenitors versus megakaryo-erythrocyte progenitors. MSigDB C7: Immunologic Signatures (v5.1) 8.513E-7 1.222E-4 1.105E-3 4.033E-3 7 177
34 M2001 Genes associated with migration rate of 40 human bladder cancer cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.104E-6 1.538E-4 1.391E-3 5.231E-3 7 184
35 M19432 Genes up-regulated during pubertal mammary gland development between week 4 and 5. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.219E-6 1.608E-4 1.454E-3 5.774E-3 8 271
36 M1472 Genes specific to BEC (blood endothelium cells) repressed in BEC by expression of PROX1 [GeneID=5629] off adenovirus vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.222E-6 1.608E-4 1.454E-3 5.790E-3 5 64
37 M1265 Selected genes up-regulated in Rat1Ras cells (fibroblasts) which were transformed by expression of an oncogenic activated form of HRAS [GeneID=3265] compared to the parental Rat1 cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.325E-6 1.696E-4 1.534E-3 6.277E-3 3 8
38 M9826 Genes whose expression is significantly and negatively correlated with poor breast cancer clinical outcome (defined as developing distant metastases in less than 5 years). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.462E-6 1.822E-4 1.647E-3 6.924E-3 6 121
39 M1784 Genes changed in U373-MG cells (malignant glioma) upon treatment with arsenic trioxide [PubChem=14888], a chemical that can cause autophagic cell death. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.609E-6 1.954E-4 1.767E-3 7.621E-3 6 123
40 M4189 Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 6 h. MSigDB C7: Immunologic Signatures (v5.1) 1.802E-6 2.028E-4 1.833E-3 8.535E-3 7 198
41 M6207 Genes up-regulated in polymorphonuclear leukocytes 9h after infection by: S. aureus versus A. phagocytophilum. MSigDB C7: Immunologic Signatures (v5.1) 1.926E-6 2.028E-4 1.833E-3 9.125E-3 7 200
42 M4636 Genes up-regulated in comparison of CD25- T cells treated with IL4 [GeneID=3565] at day 7 versus untreated CD25- T cells at day 7. MSigDB C7: Immunologic Signatures (v5.1) 1.926E-6 2.028E-4 1.833E-3 9.125E-3 7 200
43 M5939 Genes involved in p53 pathways and networks. MSigDB H: Hallmark Gene Sets (v5.1) 1.926E-6 2.028E-4 1.833E-3 9.125E-3 7 200
44 M5294 Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from young donors versus those treated with TSST at 72 h. MSigDB C7: Immunologic Signatures (v5.1) 1.926E-6 2.028E-4 1.833E-3 9.125E-3 7 200
45 GSE22103 UNSTIM VS LPS STIM NEUTROPHIL DN Genes down-regulated in neutrophils: untreated versus LPS. MSigDB C7: Immunologic Signatures (v5.1) 1.926E-6 2.028E-4 1.833E-3 9.125E-3 7 200
46 M2142 Genes up-regulated in SH-SY5Y cells (neuroblastoma) after knockdown of NF1 [GeneID=4763] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.278E-6 3.376E-4 3.052E-3 1.553E-2 6 139
47 M15835 Genes down-regulated SUM44/LCCTam cells (breast cancer) resistant to 4-hydroxytamoxifen [PubChem=63062] relative to the parental SUM44 cells sensitive to the drug. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.621E-6 3.650E-4 3.300E-3 1.715E-2 7 220
48 M1217 Genes consistently down-regulated in HMEC cells (primary mammary epithelium) upon expression of TERT [GeneID=7015] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.626E-6 5.515E-4 4.986E-3 2.665E-2 5 87
49 M988 Genes up-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.705E-6 5.515E-4 4.986E-3 2.703E-2 6 153
50 M2637 Molecular timetable composed of 96 time-indicating genes (103 probes) in the central (suprachiasmatic nucleus (SCN)) clock. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.951E-6 5.638E-4 5.097E-3 2.819E-2 5 88
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2551 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ratio SC vs MESO 500 K1 ratio StemCell vs induced-Mesoderm top-relative-expression-ranked 500 k-means-cluster#1 PCBC 5.290E-10 9.299E-7 7.831E-6 1.350E-6 7 59
2 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 7.290E-10 9.299E-7 7.831E-6 1.860E-6 13 445
3 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 200 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.960E-9 1.667E-6 1.404E-5 5.001E-6 9 167
4 BM Top 100 - parietal lobe BM Top 100 - parietal lobe Body Map 3.256E-9 1.826E-6 1.538E-5 8.305E-6 7 76
5 GSM854302 500 Stromal Cells, Ep.MEChi.Th, CD45-EpCAm+Ly51-MHCIIhi, Thymus, avg-1 Immgen.org, GSE15907 3.578E-9 1.826E-6 1.538E-5 9.129E-6 12 411
6 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 1.059E-8 4.504E-6 3.793E-5 2.702E-5 12 453
7 PCBC ratio ECTO blastocyst vs ECTO amniotic fluid MSC cfr-2X-p05 ECTO blastocyst vs ECTO amniotic fluid MSC-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.715E-8 6.250E-6 5.264E-5 4.375E-5 10 290
8 gudmap dev gonad e11.5 F ReproVasc Flk 500 dev gonad e11.5 F ReproVasc Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.989E-8 1.272E-5 1.071E-4 1.017E-4 11 409
9 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 500 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.751E-8 1.630E-5 1.373E-4 1.467E-4 11 424
10 gudmap developingGonad e11.5 testes and mesonephros k1 100 DevelopingGonad e11.5 testes and mesonephros emap-3226 k-means-cluster#1 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 7.711E-8 1.967E-5 1.657E-4 1.967E-4 4 14
11 gudmap dev gonad e11.5 F GonadVasMes Flk k3 1000 dev gonad e11.5 F GonadVasMes Flk k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.144E-7 2.654E-5 2.235E-4 2.919E-4 10 355
12 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 1.337E-7 2.721E-5 2.291E-4 3.412E-4 11 461
13 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 500 dev lower uro neuro e14.5 PelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.397E-7 2.721E-5 2.291E-4 3.563E-4 11 463
14 GSM854258 500 Myeloid Cells, DC.103-11b+.Salm3.SI, CD45+ MHCII+ Gr1- CD11c-hi CD11b+ CD103- F480+, Small Intestine, avg-4 Immgen.org, GSE15907 1.597E-7 2.721E-5 2.291E-4 4.074E-4 10 368
15 neurons SubClass glutamin-Med Top 500 Cluster 4 neurons SubClass glutamin-Med Top 500 Cluster 4 Brain Map - Barres 1.600E-7 2.721E-5 2.291E-4 4.081E-4 6 80
16 PCBC ratio EB BM CD34+ vs EB blastocyst cfr-2X-p05 EB BM CD34+ vs EB blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.995E-7 3.181E-5 2.679E-4 5.090E-4 6 83
17 GSM854262 500 Myeloid Cells, DC.103-11b+.SI, CD45+ MHCII+ CD11c-hi CD11b+ CD103- F4/80+, Small Intestine, avg-7 Immgen.org, GSE15907 2.201E-7 3.303E-5 2.781E-4 5.615E-4 10 381
18 gudmap developingGonad e11.5 testes and mesonephros k3 200 DevelopingGonad e11.5 testes and mesonephros emap-3226 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.336E-7 3.310E-5 2.788E-4 5.959E-4 4 18
19 gudmap developingGonad e11.5 testes and mesonephros k5 500 DevelopingGonad e11.5 testes and mesonephros emap-3226 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.808E-7 3.770E-5 3.175E-4 7.163E-4 5 46
20 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 100 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 3.457E-7 4.263E-5 3.590E-4 8.819E-4 6 91
21 gudmap dev gonad e11.5 F GonMes Sma k3 500 dev gonad e11.5 F GonMes Sma k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.509E-7 4.263E-5 3.590E-4 8.952E-4 7 149
22 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 100 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 5.053E-7 5.859E-5 4.934E-4 1.289E-3 6 97
23 gudmap dev gonad e11.5 F GonMes Sma k4 1000 dev gonad e11.5 F GonMes Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 6.485E-7 7.193E-5 6.058E-4 1.654E-3 9 328
24 gudmap dev gonad e11.5 M GonMes Sma 500 dev gonad e11.5 M GonMes Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 7.097E-7 7.272E-5 6.124E-4 1.810E-3 10 433
25 gudmap dev gonad e11.5 F GonMes Sma 500 dev gonad e11.5 F GonMes Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 7.715E-7 7.272E-5 6.124E-4 1.968E-3 10 437
26 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 7.876E-7 7.272E-5 6.124E-4 2.009E-3 10 438
27 26Dp Top 500 Cluster 3 26Dp Top 500 Cluster 3 Brain Map - Allen iN 8.000E-7 7.272E-5 6.124E-4 2.041E-3 4 24
28 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 500 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.379E-7 7.272E-5 6.124E-4 2.138E-3 10 441
29 GSM605862 500 Myeloid Cells, MF.Thio5.II-480hi.PC, CD115+ MHC II- F480hi Siglec F-, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 8.379E-7 7.272E-5 6.124E-4 2.138E-3 10 441
30 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 200 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 8.552E-7 7.272E-5 6.124E-4 2.182E-3 7 170
31 PCBC ratio MESO-5 blastocyst vs MESO-5 UCB CD34+Z cfr-2X-p05 MESO-5 blastocyst vs MESO-5 UCB CD34+Z-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 9.251E-7 7.575E-5 6.380E-4 2.360E-3 7 172
32 gudmap developingGonad e11.5 ovary + mesonephros k4 200 DevelopingGonad e11.5 ovary + mesonephros emap-3226 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 9.503E-7 7.575E-5 6.380E-4 2.424E-3 4 25
33 GSM538280 500 Myeloid Cells, DC.LC.Sk, MHCII+ CD11b+ CD45+, Skin, avg-2 Immgen.org, GSE15907 1.047E-6 7.968E-5 6.710E-4 2.671E-3 10 452
34 gudmap developingGonad e11.5 ovary + mesonephros k3 1000 DevelopingGonad e11.5 ovary + mesonephros emap-3226 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.062E-6 7.968E-5 6.710E-4 2.709E-3 6 110
35 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 1.112E-6 8.101E-5 6.823E-4 2.835E-3 10 455
36 GSM777037 500 Stromal Cells, BEC.SLN, gp38- CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.203E-6 8.523E-5 7.178E-4 3.068E-3 10 459
37 gudmap dev gonad e11.5 M GonMes Sma k3 500 dev gonad e11.5 M GonMes Sma k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.277E-6 8.571E-5 7.218E-4 3.257E-3 5 62
38 54Dn SubClass 54Dn 1SK Top 500 Cluster 0 54Dn SubClass 54Dn 1SK Top 500 Cluster 0 Brain Map - Allen iN 1.277E-6 8.571E-5 7.218E-4 3.257E-3 5 62
39 gudmap dev gonad e12.5 F VasAssocMesStromOvary Sma k3 500 dev gonad e12.5 F VasAssocMesStromOvary Sma k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.525E-6 9.800E-5 8.253E-4 3.891E-3 6 117
40 GSM854276 500 Myeloid Cells, DC.11cloSer.Salm3.SI, CD45+ MHCII+ Gr1- CD11c-lo CD11b+, Small Intestine, avg-4 Immgen.org, GSE15907 1.537E-6 9.800E-5 8.253E-4 3.920E-3 9 364
41 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.838E-6 1.143E-4 9.629E-4 4.688E-3 9 372
42 gudmap developingGonad e11.5 ovary + mesonephros k3 500 DevelopingGonad e11.5 ovary + mesonephros emap-3226 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.028E-6 1.199E-4 1.010E-3 5.173E-3 5 68
43 endothelial Top 500 Cluster 1 endothelial Top 500 Cluster 1 Brain Map - Barres 2.035E-6 1.199E-4 1.010E-3 5.192E-3 4 30
44 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 200 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 2.068E-6 1.199E-4 1.010E-3 5.275E-3 7 194
45 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 100 dev lower uro neuro e15.5 PelvicGanglion Sox10 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 2.344E-6 1.255E-4 1.057E-3 5.978E-3 5 70
46 neurons SubClass glutamin-Med Top 500 All neurons SubClass glutamin-Med Top 500 All Brain Map - Barres 2.367E-6 1.255E-4 1.057E-3 6.039E-3 10 495
47 GSM777041 500 Stromal Cells, Ep.MEChi.Th, CD45- EpCAm+ Ly51- MHCIIhi, Thymus, avg-2 Immgen.org, GSE15907 2.384E-6 1.255E-4 1.057E-3 6.081E-3 9 384
48 26Dn Top 500 All 26Dn Top 500 All Brain Map - Allen iN 2.410E-6 1.255E-4 1.057E-3 6.148E-3 10 496
49 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 2.410E-6 1.255E-4 1.057E-3 6.148E-3 10 496
50 BM Top 100 - frontal lobe BM Top 100 - frontal lobe Body Map 2.697E-6 1.376E-4 1.159E-3 6.879E-3 5 72
Show 45 more annotations

15: Computational [Display Chart] 238 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 8.547E-6 1.815E-3 1.099E-2 2.034E-3 10 351
2 module 3 Genes in module 3 MSigDb: C4 - CM: Cancer Modules 1.525E-5 1.815E-3 1.099E-2 3.631E-3 10 375
3 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 1.042E-4 8.268E-3
5.003E-2
2.480E-2 9 378
4 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 7.804E-4 3.774E-2
2.284E-1
1.857E-1
8 395
5 module 447 Genes in module 447 MSigDb: C4 - CM: Cancer Modules 7.930E-4 3.774E-2
2.284E-1
1.887E-1
3 36

16: MicroRNA [Display Chart] 1025 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 TGTATGA,MIR-485-3P:MSigDB TGTATGA,MIR-485-3P:MSigDB MSigDB 7.475E-5 3.191E-2
2.397E-1
7.662E-2
5 135
2 ACCATTT,MIR-522:MSigDB ACCATTT,MIR-522:MSigDB MSigDB 1.308E-4 3.191E-2
2.397E-1
1.341E-1
5 152
3 hsa-miR-148a:PITA hsa-miR-148a:PITA TOP PITA 1.557E-4 3.191E-2
2.397E-1
1.596E-1
8 483
4 hsa-miR-148b:PITA hsa-miR-148b:PITA TOP PITA 1.557E-4 3.191E-2
2.397E-1
1.596E-1
8 483
5 hsa-miR-152:PITA hsa-miR-152:PITA TOP PITA 1.557E-4 3.191E-2
2.397E-1
1.596E-1
8 483
6 hsa-miR-618:PITA hsa-miR-618:PITA TOP PITA 2.277E-4 3.890E-2
2.922E-1
2.334E-1
6 269
7 hsa-miR-299-3p:PITA hsa-miR-299-3p:PITA TOP PITA 4.247E-4 4.442E-2
3.336E-1
4.353E-1
4 109
8 hsa-miR-653:PITA hsa-miR-653:PITA TOP PITA 4.529E-4 4.442E-2
3.336E-1
4.643E-1
6 306
9 miR-136:PicTar miR-136:PicTar PicTar 5.375E-4 4.442E-2
3.336E-1
5.509E-1
4 116
10 hsa-miR-185:PITA hsa-miR-185:PITA TOP PITA 5.445E-4 4.442E-2
3.336E-1
5.581E-1
5 207
11 ACTGTGA,MIR-27A:MSigDB ACTGTGA,MIR-27A:MSigDB MSigDB 5.765E-4 4.442E-2
3.336E-1
5.909E-1
7 447
12 ACTGTGA,MIR-27B:MSigDB ACTGTGA,MIR-27B:MSigDB MSigDB 5.765E-4 4.442E-2
3.336E-1
5.909E-1
7 447
13 hsa-miR-802:PITA hsa-miR-802:PITA TOP PITA 6.157E-4 4.442E-2
3.336E-1
6.311E-1
7 452
14 hsa-miR-1292:mirSVR highEffct hsa-miR-1292:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.335E-4 4.442E-2
3.336E-1
7.518E-1
4 126
15 hsa-miR-24:PITA hsa-miR-24:PITA TOP PITA 7.622E-4 4.442E-2
3.336E-1
7.813E-1
5 223
16 hsa-miR-32:PITA hsa-miR-32:PITA TOP PITA 8.763E-4 4.442E-2
3.336E-1
8.982E-1
7 480
17 miR-126:PicTar miR-126:PicTar PicTar 9.088E-4 4.442E-2
3.336E-1
9.315E-1
2 14
18 hsa-miR-363:PITA hsa-miR-363:PITA TOP PITA 9.421E-4 4.442E-2
3.336E-1
9.657E-1
7 486
19 hsa-miR-25:PITA hsa-miR-25:PITA TOP PITA 9.535E-4 4.442E-2
3.336E-1
9.773E-1
7 487
20 hsa-miR-92a:PITA hsa-miR-92a:PITA TOP PITA 9.535E-4 4.442E-2
3.336E-1
9.773E-1
7 487
21 hsa-miR-367:PITA hsa-miR-367:PITA TOP PITA 9.535E-4 4.442E-2
3.336E-1
9.773E-1
7 487
22 hsa-miR-92b:PITA hsa-miR-92b:PITA TOP PITA 9.535E-4 4.442E-2
3.336E-1
9.773E-1
7 487
23 hsa-miR-626:PITA hsa-miR-626:PITA TOP PITA 1.058E-3 4.692E-2
3.524E-1
1.000E0
4 139
24 GTACTGT,MIR-101:MSigDB GTACTGT,MIR-101:MSigDB MSigDB 1.099E-3 4.692E-2
3.524E-1
1.000E0
5 242
Show 19 more annotations

17: Drug [Display Chart] 13963 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 D013849 Thimerosal CTD 4.126E-11 5.761E-7 5.831E-6 5.761E-7 10 164
2 C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) CTD 7.185E-10 5.016E-6 5.077E-5 1.003E-5 13 468
3 C410027 KNK 437 CTD 2.079E-8 8.315E-5 8.416E-4 2.903E-4 4 11
4 C113580 U 0126 CTD 3.242E-8 8.315E-5 8.416E-4 4.526E-4 11 422
5 3746 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 3.997E-8 8.315E-5 8.416E-4 5.582E-4 8 175
6 C021751 tanshinone CTD 4.180E-8 8.315E-5 8.416E-4 5.837E-4 7 115
7 5779 UP Ellipticine [519-23-3]; Up 200; 16.2uM; PC3; HT HG-U133A Broad Institute CMAP 4.561E-8 8.315E-5 8.416E-4 6.369E-4 8 178
8 3887 UP Camptothecine (S,+) [7689-03-4]; Up 200; 11.4uM; MCF7; HT HG-U133A Broad Institute CMAP 4.764E-8 8.315E-5 8.416E-4 6.652E-4 8 179
9 D016566 Organoselenium Compounds CTD 5.739E-8 8.904E-5 9.012E-4 8.013E-4 6 71
10 D016291 Dizocilpine Maleate CTD 1.821E-7 2.543E-4 2.574E-3 2.543E-3 6 86
11 MESH:D001943/D002945-T Breast Neoplasms affected by Cisplatin CTD Therapeutic 4.480E-7 5.405E-4 5.471E-3 6.255E-3 5 53
12 4444 UP SAHA; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 4.948E-7 5.405E-4 5.471E-3 6.909E-3 7 165
13 CID000091550 glycidamide Stitch 5.032E-7 5.405E-4 5.471E-3 7.026E-3 6 102
14 D016264 Dextran Sulfate CTD 7.079E-7 7.060E-4 7.146E-3 9.884E-3 7 174
15 1951 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HG-U133A Broad Institute CMAP 7.942E-7 7.393E-4 7.482E-3 1.109E-2 7 177
16 C488369 dasatinib CTD 9.699E-7 8.277E-4 8.377E-3 1.354E-2 10 472
17 D000069439 Dasatinib CTD 1.008E-6 8.277E-4 8.377E-3 1.407E-2 10 474
18 D012835 Silver Nitrate CTD 1.188E-6 9.215E-4 9.326E-3 1.659E-2 6 118
19 D010938 Plant Oils CTD 1.516E-6 1.107E-3 1.120E-2 2.117E-2 10 496
20 C020735 dibutyldichlorotin CTD 1.657E-6 1.107E-3 1.120E-2 2.313E-2 4 30
21 D011899 Ranitidine CTD 1.664E-6 1.107E-3 1.120E-2 2.324E-2 6 125
22 MESH:D015179/D011078-M Colorectal Neoplasms affected by Polychlorinated Biphenyls CTD Marker 1.922E-6 1.220E-3 1.235E-2 2.684E-2 3 9
23 MESH:D001943/D009532-M Breast Neoplasms affected by Nickel CTD Marker 2.740E-6 1.633E-3 1.653E-2 3.826E-2 3 10
24 MESH:D001943/D005472-T Breast Neoplasms affected by Fluorouracil CTD Therapeutic 2.924E-6 1.633E-3 1.653E-2 4.083E-2 5 77
25 C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine CTD 2.924E-6 1.633E-3 1.653E-2 4.083E-2 5 77
26 C487081 belinostat CTD 3.062E-6 1.645E-3 1.665E-2 4.276E-2 9 417
27 C437683 motexafin gadolinium CTD 4.268E-6 2.207E-3 2.234E-2
5.960E-2
6 147
28 C106014 gedunin CTD 4.498E-6 2.243E-3 2.270E-2
6.281E-2
5 84
29 C063002 2,3-dimethoxy-1,4-naphthoquinone CTD 5.375E-6 2.588E-3 2.620E-2
7.506E-2
6 153
30 C004312 glycidol CTD 6.429E-6 2.911E-3 2.946E-2
8.977E-2
9 457
31 D010664 Phenylmethylsulfonyl Fluoride CTD 6.491E-6 2.911E-3 2.946E-2
9.063E-2
3 13
32 CID000077802 3-chlorobenzylamine Stitch 6.671E-6 2.911E-3 2.946E-2
9.315E-2
5 91
33 1220 UP SAHA; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 6.951E-6 2.941E-3 2.977E-2
9.706E-2
6 160
34 D019345 Zinc Acetate CTD 8.008E-6 3.129E-3 3.167E-2
1.118E-1
6 164
35 MESH:D021441/D011794-T Carcinoma, Pancreatic Ductal affected by Quercetin CTD Therapeutic 8.257E-6 3.129E-3 3.167E-2
1.153E-1
2 2
36 MESH:D058186/D008627-M Acute Kidney Injury affected by Mercuric Chloride CTD Marker 8.257E-6 3.129E-3 3.167E-2
1.153E-1
2 2
37 2439 UP Menadione [58-27-5]; Up 200; 23.2uM; HL60; HT HG-U133A Broad Institute CMAP 8.291E-6 3.129E-3 3.167E-2
1.158E-1
6 165
38 C020175 16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione CTD 8.718E-6 3.180E-3 3.219E-2
1.217E-1
4 45
39 1234 UP Trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 8.882E-6 3.180E-3 3.219E-2
1.240E-1
6 167
40 D013750 Tetrachloroethylene CTD 9.528E-6 3.227E-3 3.266E-2
1.330E-1
4 46
41 6736 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 9.833E-6 3.227E-3 3.266E-2
1.373E-1
6 170
42 1212 UP Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 9.833E-6 3.227E-3 3.266E-2
1.373E-1
6 170
43 3318 UP Hexetidine [141-94-6]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP 1.017E-5 3.227E-3 3.266E-2
1.420E-1
6 171
44 3791 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.017E-5 3.227E-3 3.266E-2
1.420E-1
6 171
45 C078903 seocalcitol CTD 1.087E-5 3.302E-3 3.342E-2
1.517E-1
6 173
46 D003345 Corticosterone CTD 1.088E-5 3.302E-3 3.342E-2
1.519E-1
7 263
47 2456 UP Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; HL60; HT HG-U133A Broad Institute CMAP 1.123E-5 3.336E-3 3.376E-2
1.568E-1
6 174
48 7245 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.160E-5 3.374E-3 3.415E-2
1.620E-1
6 175
49 7525 UP daunorubicin HCl; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.198E-5 3.388E-3 3.429E-2
1.673E-1
6 176
50 C512195 elesclomol CTD 1.229E-5 3.388E-3 3.429E-2
1.716E-1
4 49
Show 45 more annotations

18: Disease [Display Chart] 953 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0595989 Carcinoma of larynx DisGeNET BeFree 3.978E-6 3.791E-3 2.820E-2 3.791E-3 7 180
2 umls:C1516170 Cancer Cell Growth DisGeNET BeFree 2.004E-5 6.838E-3
5.085E-2
1.910E-2 8 320
3 umls:C0346957 Disseminated Malignant Neoplasm DisGeNET BeFree 2.696E-5 6.838E-3
5.085E-2
2.569E-2 6 162
4 umls:C0033103 Pretibial myxedema DisGeNET BeFree 3.927E-5 6.838E-3
5.085E-2
3.742E-2 2 3
5 umls:C0341318 Enterocutaneous Fistula DisGeNET BeFree 3.927E-5 6.838E-3
5.085E-2
3.742E-2 2 3
6 umls:C0024517 Single major depressive episode DisGeNET BeFree 4.305E-5 6.838E-3
5.085E-2
4.103E-2 3 19
7 umls:C1704272 Benign Prostatic Hyperplasia DisGeNET BeFree 5.954E-5 8.106E-3
6.029E-2
5.674E-2
8 373
8 umls:C1335177 Ovarian Serous Adenocarcinoma DisGeNET BeFree 8.667E-5 1.032E-2
7.679E-2
8.260E-2
4 64
9 umls:C0278996 Cancer of Head and Neck DisGeNET BeFree 1.075E-4 1.129E-2
8.395E-2
1.025E-1
8 406
10 umls:C0280324 Laryngeal Squamous Cell Carcinoma DisGeNET Curated 1.275E-4 1.129E-2
8.395E-2
1.215E-1
5 134
11 umls:C0085119 Foot Ulcer DisGeNET BeFree 1.303E-4 1.129E-2
8.395E-2
1.242E-1
2 5
12 umls:C0205788 Histiocytoid hemangioma DisGeNET BeFree 1.950E-4 1.312E-2
9.761E-2
1.858E-1
2 6
13 umls:C1334956 Neuroepithelial, Perineurial, and Schwann Cell Neoplasm DisGeNET BeFree 1.950E-4 1.312E-2
9.761E-2
1.858E-1
2 6
14 umls:C1519670 Tumor Angiogenesis DisGeNET BeFree 1.957E-4 1.312E-2
9.761E-2
1.865E-1
8 443
15 umls:C0003507 Aortic Valve Stenosis DisGeNET BeFree 2.066E-4 1.312E-2
9.761E-2
1.969E-1
4 80
16 umls:C0278488 Carcinoma breast stage IV DisGeNET BeFree 2.338E-4 1.392E-2
1.036E-1
2.228E-1
7 341
17 umls:C0403416 Idiopathic crescentic glomerulonephritis DisGeNET BeFree 4.473E-4 2.454E-2
1.825E-1
4.263E-1
3 41
18 umls:C0013537 Eclampsia DisGeNET BeFree 4.636E-4 2.454E-2
1.825E-1
4.418E-1
5 177
19 umls:C0014474 Ependymoma DisGeNET Curated 6.487E-4 3.011E-2
2.239E-1
6.182E-1
4 108
20 umls:C0041696 Unipolar Depression DisGeNET BeFree 6.567E-4 3.011E-2
2.239E-1
6.259E-1
7 405
21 umls:C0334538 Epithelioid hemangioendothelioma, malignant DisGeNET BeFree 7.065E-4 3.011E-2
2.239E-1
6.733E-1
2 11
22 umls:C0262655 Recurrent urinary tract infection DisGeNET BeFree 7.065E-4 3.011E-2
2.239E-1
6.733E-1
2 11
23 umls:C0555198 Malignant Glioma DisGeNET BeFree 7.266E-4 3.011E-2
2.239E-1
6.924E-1
7 412
24 umls:C0040136 Thyroid Neoplasm DisGeNET Curated 9.443E-4 3.695E-2
2.748E-1
8.999E-1
6 312
25 umls:C0206732 Epithelioid hemangioendothelioma DisGeNET Curated 9.973E-4 3.695E-2
2.748E-1
9.504E-1
2 13
26 umls:C1269683 Major Depressive Disorder DisGeNET Curated 1.012E-3 3.695E-2
2.748E-1
9.644E-1
7 436
27 umls:C0008479 Chondrosarcoma DisGeNET Curated 1.047E-3 3.695E-2
2.748E-1
9.976E-1
5 212
28 umls:C0238463 Papillary thyroid carcinoma DisGeNET Curated 1.154E-3 3.828E-2
2.847E-1
1.000E0
7 446
29 umls:C3542024 AORTIC VALVE DISEASE 2 DisGeNET Curated 1.239E-3 3.828E-2
2.847E-1
1.000E0
3 58
30 umls:C0007107 Malignant neoplasm of larynx DisGeNET BeFree 1.296E-3 3.828E-2
2.847E-1
1.000E0
4 130
31 umls:C0334579 Anaplastic astrocytoma DisGeNET Curated 1.572E-3 3.828E-2
2.847E-1
1.000E0
4 137
32 umls:C1512409 Hepatocarcinogenesis DisGeNET BeFree 1.580E-3 3.828E-2
2.847E-1
1.000E0
7 471
33 umls:C0042373 Vascular Diseases DisGeNET Curated 1.604E-3 3.828E-2
2.847E-1
1.000E0
6 346
34 umls:C0016057 Fibrosarcoma DisGeNET Curated 1.845E-3 3.828E-2
2.847E-1
1.000E0
5 241
35 umls:C0235950 Zinc deficiency DisGeNET BeFree 1.933E-3 3.828E-2
2.847E-1
1.000E0
2 18
36 umls:C0279702 Conventional (Clear Cell) Renal Cell Carcinoma DisGeNET Curated 2.159E-3 3.828E-2
2.847E-1
1.000E0
6 367
37 umls:C0206180 Ki-1+ Anaplastic Large Cell Lymphoma DisGeNET Curated 2.202E-3 3.828E-2
2.847E-1
1.000E0
5 251
38 umls:C0265101 Carotid artery occlusion DisGeNET BeFree 2.390E-3 3.828E-2
2.847E-1
1.000E0
2 20
39 umls:C0032285 Pneumonia DisGeNET Curated 2.437E-3 3.828E-2
2.847E-1
1.000E0
6 376
40 umls:C0079772 T-Cell Lymphoma DisGeNET Curated 2.523E-3 3.828E-2
2.847E-1
1.000E0
5 259
41 umls:C0018021 Goiter DisGeNET Curated 2.595E-3 3.828E-2
2.847E-1
1.000E0
3 75
42 umls:C0158266 Intervertebral Disc Degeneration DisGeNET Curated 2.695E-3 3.828E-2
2.847E-1
1.000E0
3 76
43 umls:C0740457 Malignant neoplasm of kidney DisGeNET BeFree 2.741E-3 3.828E-2
2.847E-1
1.000E0
6 385
44 umls:C0007785 Cerebral Infarction DisGeNET Curated 2.785E-3 3.828E-2
2.847E-1
1.000E0
5 265
45 umls:C0149521 Pancreatitis, Chronic DisGeNET Curated 3.066E-3 3.828E-2
2.847E-1
1.000E0
5 271
46 umls:C0017658 Glomerulonephritis DisGeNET Curated 3.157E-3 3.828E-2
2.847E-1
1.000E0
4 166
47 umls:C0026780 Mumps DisGeNET BeFree 3.160E-3 3.828E-2
2.847E-1
1.000E0
2 23
48 umls:C0282666 Very Low Birth Weight DisGeNET BeFree 3.439E-3 3.828E-2
2.847E-1
1.000E0
2 24
49 umls:C1836173 Generalized Epilepsy and Paroxysmal Dyskinesia DisGeNET Curated 3.653E-3 3.828E-2
2.847E-1
1.000E0
1 1
50 607684 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2E; CMT2E OMIM 3.653E-3 3.828E-2
2.847E-1
1.000E0
1 1
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