|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
M2726
|
Genes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] MCF-7 cells (breast cancer) stably over-expressing constitutively active RAF1 [Gene ID=5894] gene.
|
MSigDB C6: Oncogenic Signatures (v5.1)
|
9.951E-12
|
4.714E-8
|
4.262E-7
|
4.714E-8
|
11
|
194
|
2
|
M10508
|
Genes known to be induced by hypoxia
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
9.308E-11
|
1.721E-7
|
1.555E-6
|
4.409E-7
|
8
|
81
|
3
|
M2293
|
Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512].
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
1.090E-10
|
1.721E-7
|
1.555E-6
|
5.162E-7
|
12
|
315
|
4
|
GSE37301 HEMATOPOIETIC STEM CELL VS RAG2 KO NK CELL DN
|
Genes down-regulated in hematopoietic stem cells versus NK cells with RAG2 [GeneID=5897] knockout.
|
MSigDB C7: Immunologic Signatures (v5.1)
|
2.649E-9
|
3.138E-6
|
2.837E-5
|
1.255E-5
|
9
|
180
|
5
|
M15981
|
Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
3.742E-9
|
3.545E-6
|
3.205E-5
|
1.772E-5
|
12
|
430
|
6
|
M1597
|
Cluster 2: genes maximally expressed at 2 h time point during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) in response to adipogenic hormones.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
8.032E-9
|
6.159E-6
|
5.568E-5
|
3.805E-5
|
6
|
51
|
7
|
M4780
|
Genes down-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
9.101E-9
|
6.159E-6
|
5.568E-5
|
4.311E-5
|
11
|
369
|
8
|
M1459
|
Genes up-regulated in BEC (blood endothelial cells) compared to LEC (lymphatic endothelial cells).
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
2.374E-8
|
1.298E-5
|
1.173E-4
|
1.125E-4
|
8
|
162
|
9
|
M2700
|
Genes down-regulated in bone relapse of breast cancer.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
2.465E-8
|
1.298E-5
|
1.173E-4
|
1.168E-4
|
10
|
314
|
10
|
M14072
|
Genes regulated by hypoxia, based on literature searches.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
3.481E-8
|
1.546E-5
|
1.398E-4
|
1.649E-4
|
9
|
242
|
11
|
M7363
|
Genes up-regulated in MCF7 cells (breast cancer) under hypoxia conditions.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
3.618E-8
|
1.546E-5
|
1.398E-4
|
1.714E-4
|
8
|
171
|
12
|
M1417
|
Genes down-regulated during epithelial to mesenchymal transition (EMT) induced by TGFB1 [GeneID=7040] in the EpH4 cells (mammary epithelium cell line transformed by HRAS [GeneID=3265]).
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
3.916E-8
|
1.546E-5
|
1.398E-4
|
1.855E-4
|
6
|
66
|
13
|
M5681
|
Genes up-regulated in apoptotic tissues (neuroepithelium) after MDM4 [GeneID=4194] knockout.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
4.527E-8
|
1.649E-5
|
1.491E-4
|
2.144E-4
|
8
|
176
|
14
|
M2879
|
Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265].
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
5.502E-8
|
1.862E-5
|
1.683E-4
|
2.606E-4
|
10
|
342
|
15
|
M3645
|
Genes up-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
5.902E-8
|
1.864E-5
|
1.685E-4
|
2.796E-4
|
11
|
443
|
16
|
M12338
|
Genes changed in NIH 3T3 cells (embryonic fibroblast) by expression of one or more of C/EBP proteins: CEBPA, CEBPB, CEBPG, and CEBPD [GeneID=1050;1051;1054;1052].
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
8.433E-8
|
2.460E-5
|
2.224E-4
|
3.995E-4
|
7
|
126
|
17
|
M14127
|
Genes up-regulated in multiple myeloma (MM) cell lines treated with both decitabine [PubChem=451668] TSA [PubChem=5562].
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
8.827E-8
|
2.460E-5
|
2.224E-4
|
4.181E-4
|
11
|
461
|
18
|
M4306
|
Genes down-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
9.423E-8
|
2.480E-5
|
2.242E-4
|
4.464E-4
|
11
|
464
|
19
|
M9197
|
Genes up-regulated in MCF7 cells (breast cancer) treated with hypoxia mimetic DMOG [PubChem=3080614].
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
1.046E-7
|
2.607E-5
|
2.357E-4
|
4.953E-4
|
7
|
130
|
20
|
M3013
|
Genes down-regulated in comparison of naive versus effector CD8 T cells at the peak expansion phase (day8 after LCMV-Armstrong infection).
|
MSigDB C7: Immunologic Signatures (v5.1)
|
1.215E-7
|
2.741E-5
|
2.478E-4
|
5.756E-4
|
8
|
200
|
21
|
M5924
|
Genes up-regulated through activation of mTORC1 complex.
|
MSigDB H: Hallmark Gene Sets (v5.1)
|
1.215E-7
|
2.741E-5
|
2.478E-4
|
5.756E-4
|
8
|
200
|
22
|
M1914
|
Genes up-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101].
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
1.779E-7
|
3.830E-5
|
3.463E-4
|
8.427E-4
|
9
|
293
|
23
|
M2506
|
Genes up-regulated in the neural crest stem cells (NCS), defined as p75+/HNK1+ [GeneID=4804;27087].
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
2.313E-7
|
4.765E-5
|
4.308E-4
|
1.096E-3
|
7
|
146
|
24
|
GSE36891 UNSTIM VS POLYIC TLR3 STIM PERITONEAL MACROPHAGE UP
|
Genes up-regulated in peritoneal macrophages: untreated versus poly(IC).
|
MSigDB C7: Immunologic Signatures (v5.1)
|
2.424E-7
|
4.784E-5
|
4.325E-4
|
1.148E-3
|
7
|
147
|
25
|
M19467
|
Genes down-regulated in five primary endothelial cell types (lung, aortic, iliac, dermal, and colon) by TNF [GeneID=7124].
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
2.541E-7
|
4.815E-5
|
4.353E-4
|
1.204E-3
|
6
|
90
|
26
|
M10279
|
Genes down-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [GeneID=9589] by RNAi.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
2.863E-7
|
5.216E-5
|
4.715E-4
|
1.356E-3
|
9
|
310
|
27
|
M2256
|
Genes commonly down-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313 ,2078].
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
3.200E-7
|
5.615E-5
|
5.076E-4
|
1.516E-3
|
8
|
227
|
28
|
M863
|
Myb-regulated genes in MCF7 (breast cancer) and lung epithelial cell lines overexpressing MYBL2, MYBL1 or MYB [GeneID=4605;4603;4602].
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
3.546E-7
|
5.999E-5
|
5.424E-4
|
1.680E-3
|
9
|
318
|
29
|
M4716
|
Genes up-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402], a protease inhibitor causing apoptosis.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
4.732E-7
|
7.729E-5
|
6.987E-4
|
2.241E-3
|
8
|
239
|
30
|
M6189
|
Genes down-regulated in MCF7 cells (breast cancer) after knockdown of both HIF1A and HIF2A [GeneID=3091;2034] by RNAi.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
5.999E-7
|
9.472E-5
|
8.563E-4
|
2.841E-3
|
6
|
104
|
31
|
M16108
|
Genes down-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402], a protease inhibitor causing apoptosis.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
7.021E-7
|
1.073E-4
|
9.699E-4
|
3.326E-3
|
7
|
172
|
32
|
M19768
|
Genes downregulated in MCF10A cells (breast cancer) co-cultured with cancer-associated fibroblasts (CAF).
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
7.496E-7
|
1.110E-4
|
1.003E-3
|
3.551E-3
|
6
|
108
|
33
|
GSE15330 LYMPHOID MULTIPOTENT VS MEGAKARYOCYTE ERYTHROID PROGENITOR IKAROS KO DN
|
Genes down-regulated in IKZF1 [GeneID=10320] knockout: lymphoid-primed multipotent progenitors versus megakaryo-erythrocyte progenitors.
|
MSigDB C7: Immunologic Signatures (v5.1)
|
8.513E-7
|
1.222E-4
|
1.105E-3
|
4.033E-3
|
7
|
177
|
34
|
M2001
|
Genes associated with migration rate of 40 human bladder cancer cells.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
1.104E-6
|
1.538E-4
|
1.391E-3
|
5.231E-3
|
7
|
184
|
35
|
M19432
|
Genes up-regulated during pubertal mammary gland development between week 4 and 5.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
1.219E-6
|
1.608E-4
|
1.454E-3
|
5.774E-3
|
8
|
271
|
36
|
M1472
|
Genes specific to BEC (blood endothelium cells) repressed in BEC by expression of PROX1 [GeneID=5629] off adenovirus vector.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
1.222E-6
|
1.608E-4
|
1.454E-3
|
5.790E-3
|
5
|
64
|
37
|
M1265
|
Selected genes up-regulated in Rat1Ras cells (fibroblasts) which were transformed by expression of an oncogenic activated form of HRAS [GeneID=3265] compared to the parental Rat1 cells.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
1.325E-6
|
1.696E-4
|
1.534E-3
|
6.277E-3
|
3
|
8
|
38
|
M9826
|
Genes whose expression is significantly and negatively correlated with poor breast cancer clinical outcome (defined as developing distant metastases in less than 5 years).
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
1.462E-6
|
1.822E-4
|
1.647E-3
|
6.924E-3
|
6
|
121
|
39
|
M1784
|
Genes changed in U373-MG cells (malignant glioma) upon treatment with arsenic trioxide [PubChem=14888], a chemical that can cause autophagic cell death.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
1.609E-6
|
1.954E-4
|
1.767E-3
|
7.621E-3
|
6
|
123
|
40
|
M4189
|
Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 6 h.
|
MSigDB C7: Immunologic Signatures (v5.1)
|
1.802E-6
|
2.028E-4
|
1.833E-3
|
8.535E-3
|
7
|
198
|
41
|
M6207
|
Genes up-regulated in polymorphonuclear leukocytes 9h after infection by: S. aureus versus A. phagocytophilum.
|
MSigDB C7: Immunologic Signatures (v5.1)
|
1.926E-6
|
2.028E-4
|
1.833E-3
|
9.125E-3
|
7
|
200
|
42
|
M4636
|
Genes up-regulated in comparison of CD25- T cells treated with IL4 [GeneID=3565] at day 7 versus untreated CD25- T cells at day 7.
|
MSigDB C7: Immunologic Signatures (v5.1)
|
1.926E-6
|
2.028E-4
|
1.833E-3
|
9.125E-3
|
7
|
200
|
43
|
M5939
|
Genes involved in p53 pathways and networks.
|
MSigDB H: Hallmark Gene Sets (v5.1)
|
1.926E-6
|
2.028E-4
|
1.833E-3
|
9.125E-3
|
7
|
200
|
44
|
M5294
|
Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from young donors versus those treated with TSST at 72 h.
|
MSigDB C7: Immunologic Signatures (v5.1)
|
1.926E-6
|
2.028E-4
|
1.833E-3
|
9.125E-3
|
7
|
200
|
45
|
GSE22103 UNSTIM VS LPS STIM NEUTROPHIL DN
|
Genes down-regulated in neutrophils: untreated versus LPS.
|
MSigDB C7: Immunologic Signatures (v5.1)
|
1.926E-6
|
2.028E-4
|
1.833E-3
|
9.125E-3
|
7
|
200
|
46
|
M2142
|
Genes up-regulated in SH-SY5Y cells (neuroblastoma) after knockdown of NF1 [GeneID=4763] by RNAi.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
3.278E-6
|
3.376E-4
|
3.052E-3
|
1.553E-2
|
6
|
139
|
47
|
M15835
|
Genes down-regulated SUM44/LCCTam cells (breast cancer) resistant to 4-hydroxytamoxifen [PubChem=63062] relative to the parental SUM44 cells sensitive to the drug.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
3.621E-6
|
3.650E-4
|
3.300E-3
|
1.715E-2
|
7
|
220
|
48
|
M1217
|
Genes consistently down-regulated in HMEC cells (primary mammary epithelium) upon expression of TERT [GeneID=7015] off a retroviral vector.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
5.626E-6
|
5.515E-4
|
4.986E-3
|
2.665E-2
|
5
|
87
|
49
|
M988
|
Genes up-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371].
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
5.705E-6
|
5.515E-4
|
4.986E-3
|
2.703E-2
|
6
|
153
|
50
|
M2637
|
Molecular timetable composed of 96 time-indicating genes (103 probes) in the central (suprachiasmatic nucleus (SCN)) clock.
|
MSigDB C2: CGP Curated Gene Sets (v5.1)
|
5.951E-6
|
5.638E-4
|
5.097E-3
|
2.819E-2
|
5
|
88
|