Toppgene analysis for aggregated_1964_log, IC6, positive side

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1: GO: Molecular Function [Display Chart] 877 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008137 NADH dehydrogenase (ubiquinone) activity 1.195E-18 3.492E-16 2.568E-15 1.048E-15 18 46
2 GO:0050136 NADH dehydrogenase (quinone) activity 1.195E-18 3.492E-16 2.568E-15 1.048E-15 18 46
3 GO:0003954 NADH dehydrogenase activity 1.195E-18 3.492E-16 2.568E-15 1.048E-15 18 46
4 GO:0003735 structural constituent of ribosome 7.147E-18 1.504E-15 1.106E-14 6.268E-15 32 216
5 GO:0015078 hydrogen ion transmembrane transporter activity 8.573E-18 1.504E-15 1.106E-14 7.518E-15 24 109
6 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 2.971E-16 4.343E-14 3.194E-13 2.606E-13 18 60
7 GO:0016651 oxidoreductase activity, acting on NAD(P)H 4.072E-16 5.101E-14 3.752E-13 3.571E-13 22 103
8 GO:0070003 threonine-type peptidase activity 1.230E-13 1.198E-11 8.814E-11 1.079E-10 11 21
9 GO:0004298 threonine-type endopeptidase activity 1.230E-13 1.198E-11 8.814E-11 1.079E-10 11 21
10 GO:0043021 ribonucleoprotein complex binding 1.888E-11 1.656E-9 1.218E-8 1.656E-8 19 123
11 GO:0070990 snRNP binding 2.386E-10 1.902E-8 1.399E-7 2.092E-7 7 10
12 GO:0009055 electron carrier activity 5.135E-10 3.753E-8 2.760E-7 4.503E-7 17 116
13 GO:1990446 U1 snRNP binding 2.663E-9 1.797E-7 1.321E-6 2.336E-6 6 8
14 GO:0003743 translation initiation factor activity 9.267E-9 5.805E-7 4.269E-6 8.127E-6 11 51
15 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 3.502E-8 2.048E-6 1.506E-5 3.071E-5 8 25
16 GO:0036442 hydrogen-exporting ATPase activity 1.288E-7 7.061E-6 5.193E-5 1.130E-4 8 29
17 GO:0008135 translation factor activity, RNA binding 5.331E-7 2.639E-5 1.941E-4 4.675E-4 12 90
18 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity 5.416E-7 2.639E-5 1.941E-4 4.750E-4 5 9
19 GO:0019829 cation-transporting ATPase activity 7.906E-7 3.649E-5 2.684E-4 6.933E-4 10 62
20 GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor 1.681E-6 6.441E-5 4.737E-4 1.474E-3 7 28
21 GO:0015002 heme-copper terminal oxidase activity 1.681E-6 6.441E-5 4.737E-4 1.474E-3 7 28
22 GO:0004129 cytochrome-c oxidase activity 1.681E-6 6.441E-5 4.737E-4 1.474E-3 7 28
23 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 1.809E-6 6.441E-5 4.737E-4 1.587E-3 9 53
24 GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity 1.836E-6 6.441E-5 4.737E-4 1.610E-3 13 119
25 GO:0015399 primary active transmembrane transporter activity 1.836E-6 6.441E-5 4.737E-4 1.610E-3 13 119
26 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1.916E-6 6.463E-5 4.753E-4 1.680E-3 5 11
27 GO:0016675 oxidoreductase activity, acting on a heme group of donors 2.174E-6 7.063E-5 5.194E-4 1.907E-3 7 29
28 GO:0015077 monovalent inorganic cation transmembrane transporter activity 2.429E-6 7.609E-5 5.596E-4 2.131E-3 24 375
29 GO:0042625 ATPase coupled ion transmembrane transporter activity 4.194E-6 1.268E-4 9.327E-4 3.678E-3 10 74
30 GO:0046961 proton-transporting ATPase activity, rotational mechanism 7.288E-6 2.130E-4 1.567E-3 6.391E-3 6 23
31 GO:0051920 peroxiredoxin activity 1.409E-5 3.985E-4 2.931E-3 1.235E-2 4 8
32 GO:0001055 RNA polymerase II activity 4.083E-5 1.078E-3 7.928E-3 3.581E-2 4 10
33 GO:0016209 antioxidant activity 4.170E-5 1.078E-3 7.928E-3 3.657E-2 9 77
34 GO:0008320 protein transmembrane transporter activity 4.179E-5 1.078E-3 7.928E-3 3.665E-2 5 19
35 GO:0015036 disulfide oxidoreductase activity 6.659E-5 1.669E-3 1.227E-2
5.840E-2
 6 33
36 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 7.201E-5 1.754E-3 1.290E-2
6.315E-2
 7 48
37 GO:0022884 macromolecule transmembrane transporter activity 8.972E-5 2.127E-3 1.564E-2
7.869E-2
 5 22
38 GO:0015266 protein channel activity 9.298E-5 2.146E-3 1.578E-2
8.155E-2
 4 12
39 GO:0004300 enoyl-CoA hydratase activity 9.722E-5 2.186E-3 1.608E-2
8.526E-2
 3 5
40 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism 1.320E-4 2.895E-3 2.129E-2
1.158E-1
 4 13
41 GO:0042626 ATPase activity, coupled to transmembrane movement of substances 1.374E-4 2.938E-3 2.161E-2
1.205E-1
 10 110
42 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 1.481E-4 3.093E-3 2.274E-2
1.299E-1
 10 111
43 GO:0036402 proteasome-activating ATPase activity 1.913E-4 3.902E-3 2.870E-2
1.678E-1
 3 6
44 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3.004E-4 5.973E-3 4.392E-2
2.635E-1
 10 121
45 GO:0034603 pyruvate dehydrogenase [NAD(P)+] activity 3.294E-4 5.973E-3 4.392E-2
2.889E-1
 3 7
46 GO:0004738 pyruvate dehydrogenase activity 3.294E-4 5.973E-3 4.392E-2
2.889E-1
 3 7
47 GO:0034604 pyruvate dehydrogenase (NAD+) activity 3.294E-4 5.973E-3 4.392E-2
2.889E-1
 3 7
48 GO:0015288 porin activity 3.294E-4 5.973E-3 4.392E-2
2.889E-1
 3 7
49 GO:0016875 ligase activity, forming carbon-oxygen bonds 3.473E-4 5.973E-3 4.392E-2
3.046E-1
 6 44
50 GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds 3.473E-4 5.973E-3 4.392E-2
3.046E-1
 6 44
Show 45 more annotations

2: GO: Biological Process [Display Chart] 3221 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0045333 cellular respiration 7.317E-34 2.357E-30 2.040E-29 2.357E-30 44 179
2 GO:0022904 respiratory electron transport chain 1.230E-29 1.981E-26 1.715E-25 3.963E-26 33 104
3 GO:0042775 mitochondrial ATP synthesis coupled electron transport 3.487E-29 2.860E-26 2.475E-25 1.123E-25 30 82
4 GO:0022900 electron transport chain 3.551E-29 2.860E-26 2.475E-25 1.144E-25 33 107
5 GO:0042773 ATP synthesis coupled electron transport 1.237E-28 7.971E-26 6.899E-25 3.986E-25 30 85
6 GO:0009167 purine ribonucleoside monophosphate metabolic process 3.000E-28 1.611E-25 1.394E-24 9.663E-25 47 279
7 GO:0009126 purine nucleoside monophosphate metabolic process 3.537E-28 1.627E-25 1.408E-24 1.139E-24 47 280
8 GO:0046034 ATP metabolic process 6.257E-28 2.519E-25 2.180E-24 2.015E-24 44 242
9 GO:0009161 ribonucleoside monophosphate metabolic process 2.063E-27 7.236E-25 6.263E-24 6.644E-24 47 291
10 GO:0009205 purine ribonucleoside triphosphate metabolic process 2.247E-27 7.236E-25 6.263E-24 7.236E-24 45 263
11 GO:0009199 ribonucleoside triphosphate metabolic process 7.144E-27 2.092E-24 1.811E-23 2.301E-23 45 270
12 GO:0009144 purine nucleoside triphosphate metabolic process 8.403E-27 2.256E-24 1.952E-23 2.707E-23 45 271
13 GO:0009123 nucleoside monophosphate metabolic process 1.496E-26 3.707E-24 3.208E-23 4.819E-23 47 304
14 GO:0006119 oxidative phosphorylation 2.148E-26 4.942E-24 4.277E-23 6.918E-23 31 108
15 GO:0009141 nucleoside triphosphate metabolic process 3.640E-26 7.817E-24 6.765E-23 1.172E-22 46 295
16 GO:0015980 energy derivation by oxidation of organic compounds 1.024E-25 2.062E-23 1.785E-22 3.299E-22 45 287
17 GO:0006091 generation of precursor metabolites and energy 5.265E-25 9.975E-23 8.633E-22 1.696E-21 51 395
18 GO:0046128 purine ribonucleoside metabolic process 4.396E-24 7.866E-22 6.807E-21 1.416E-20 48 362
19 GO:0042278 purine nucleoside metabolic process 6.341E-24 1.075E-21 9.304E-21 2.042E-20 48 365
20 GO:0009119 ribonucleoside metabolic process 2.040E-23 3.285E-21 2.843E-20 6.570E-20 49 392
21 GO:0009116 nucleoside metabolic process 3.342E-23 5.126E-21 4.436E-20 1.076E-19 50 414
22 GO:1901657 glycosyl compound metabolic process 5.139E-23 7.524E-21 6.512E-20 1.655E-19 51 436
23 GO:0033108 mitochondrial respiratory chain complex assembly 1.182E-21 1.655E-19 1.432E-18 3.806E-18 24 77
24 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 3.077E-21 4.129E-19 3.574E-18 9.910E-18 23 71
25 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 4.432E-21 5.694E-19 4.928E-18 1.427E-17 23 72
26 GO:0051444 negative regulation of ubiquitin-protein transferase activity 4.596E-21 5.694E-19 4.928E-18 1.481E-17 24 81
27 GO:0006120 mitochondrial electron transport, NADH to ubiquinone 5.455E-21 6.507E-19 5.632E-18 1.757E-17 20 49
28 GO:1904667 negative regulation of ubiquitin protein ligase activity 6.343E-21 7.297E-19 6.315E-18 2.043E-17 23 73
29 GO:0051352 negative regulation of ligase activity 8.786E-21 9.758E-19 8.446E-18 2.830E-17 24 83
30 GO:0070125 mitochondrial translational elongation 1.647E-20 1.769E-18 1.531E-17 5.306E-17 24 85
31 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition 1.793E-20 1.863E-18 1.613E-17 5.776E-17 23 76
32 GO:0070126 mitochondrial translational termination 2.240E-20 2.255E-18 1.951E-17 7.215E-17 24 86
33 GO:0031145 anaphase-promoting complex-dependent catabolic process 2.507E-20 2.447E-18 2.118E-17 8.074E-17 23 77
34 GO:0006415 translational termination 5.302E-20 5.022E-18 4.347E-17 1.708E-16 25 99
35 GO:0006414 translational elongation 7.485E-20 6.888E-18 5.962E-17 2.411E-16 28 134
36 GO:1904668 positive regulation of ubiquitin protein ligase activity 9.079E-20 8.123E-18 7.030E-17 2.924E-16 23 81
37 GO:0097031 mitochondrial respiratory chain complex I biogenesis 1.318E-19 1.089E-17 9.424E-17 4.247E-16 20 56
38 GO:0010257 NADH dehydrogenase complex assembly 1.318E-19 1.089E-17 9.424E-17 4.247E-16 20 56
39 GO:0032981 mitochondrial respiratory chain complex I assembly 1.318E-19 1.089E-17 9.424E-17 4.247E-16 20 56
40 GO:0051443 positive regulation of ubiquitin-protein transferase activity 1.518E-19 1.222E-17 1.058E-16 4.889E-16 25 103
41 GO:0006521 regulation of cellular amino acid metabolic process 2.584E-19 2.030E-17 1.757E-16 8.325E-16 21 66
42 GO:1904666 regulation of ubiquitin protein ligase activity 3.043E-19 2.334E-17 2.020E-16 9.803E-16 23 85
43 GO:1902600 hydrogen ion transmembrane transport 5.276E-19 3.952E-17 3.421E-16 1.700E-15 25 108
44 GO:0051438 regulation of ubiquitin-protein transferase activity 6.113E-19 4.475E-17 3.873E-16 1.969E-15 26 120
45 GO:0051351 positive regulation of ligase activity 6.712E-19 4.804E-17 4.158E-16 2.162E-15 25 109
46 GO:0051340 regulation of ligase activity 1.182E-18 8.278E-17 7.164E-16 3.808E-15 26 123
47 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process 2.150E-18 1.474E-16 1.275E-15 6.926E-15 23 92
48 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 2.808E-18 1.884E-16 1.631E-15 9.045E-15 20 64
49 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 3.635E-18 2.389E-16 2.068E-15 1.171E-14 23 94
50 GO:0032543 mitochondrial translation 8.019E-18 5.166E-16 4.471E-15 2.583E-14 25 120
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 574 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0098798 mitochondrial protein complex 6.044E-46 3.469E-43 2.404E-42 3.469E-43 50 150
2 GO:0098800 inner mitochondrial membrane protein complex 5.197E-41 1.491E-38 1.034E-37 2.983E-38 42 113
3 GO:0044455 mitochondrial membrane part 4.605E-39 8.812E-37 6.107E-36 2.644E-36 49 189
4 GO:0070469 respiratory chain 9.917E-31 1.423E-28 9.863E-28 5.692E-28 32 90
5 GO:0005746 mitochondrial respiratory chain 3.332E-29 3.826E-27 2.651E-26 1.913E-26 29 75
6 GO:0098803 respiratory chain complex 1.214E-27 1.161E-25 8.048E-25 6.967E-25 27 68
7 GO:0005759 mitochondrial matrix 1.969E-25 1.615E-23 1.119E-22 1.130E-22 53 425
8 GO:1990204 oxidoreductase complex 1.008E-22 7.231E-21 5.011E-20 5.785E-20 27 98
9 GO:0005840 ribosome 1.629E-21 1.039E-19 7.200E-19 9.350E-19 37 235
10 GO:0005747 mitochondrial respiratory chain complex I 6.783E-21 3.244E-19 2.249E-18 3.893E-18 19 43
11 GO:0045271 respiratory chain complex I 6.783E-21 3.244E-19 2.249E-18 3.893E-18 19 43
12 GO:0030964 NADH dehydrogenase complex 6.783E-21 3.244E-19 2.249E-18 3.893E-18 19 43
13 GO:0044391 ribosomal subunit 8.723E-21 3.852E-19 2.669E-18 5.007E-18 32 175
14 GO:0005761 mitochondrial ribosome 7.455E-19 2.853E-17 1.977E-16 4.279E-16 22 79
15 GO:0000313 organellar ribosome 7.455E-19 2.853E-17 1.977E-16 4.279E-16 22 79
16 GO:0000502 proteasome complex 1.763E-16 6.324E-15 4.383E-14 1.012E-13 20 78
17 GO:0043209 myelin sheath 6.966E-16 2.352E-14 1.630E-13 3.998E-13 29 204
18 GO:0005839 proteasome core complex 5.582E-14 1.780E-12 1.234E-11 3.204E-11 11 20
19 GO:0000315 organellar large ribosomal subunit 3.855E-13 1.106E-11 7.668E-11 2.213E-10 13 37
20 GO:0005762 mitochondrial large ribosomal subunit 3.855E-13 1.106E-11 7.668E-11 2.213E-10 13 37
21 GO:0016469 proton-transporting two-sector ATPase complex 8.927E-13 2.440E-11 1.691E-10 5.124E-10 14 48
22 GO:0005753 mitochondrial proton-transporting ATP synthase complex 5.383E-12 1.404E-10 9.733E-10 3.090E-9 10 21
23 GO:0015934 large ribosomal subunit 9.562E-12 2.386E-10 1.654E-9 5.488E-9 18 105
24 GO:0045259 proton-transporting ATP synthase complex 1.680E-11 4.018E-10 2.785E-9 9.644E-9 10 23
25 GO:0031970 organelle envelope lumen 1.099E-10 2.524E-9 1.749E-8 6.309E-8 16 92
26 GO:0005758 mitochondrial intermembrane space 1.388E-10 3.065E-9 2.124E-8 7.968E-8 15 80
27 GO:0015935 small ribosomal subunit 3.460E-10 7.356E-9 5.099E-8 1.986E-7 14 72
28 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain 5.610E-10 1.150E-8 7.970E-8 3.220E-7 9 23
29 GO:0022624 proteasome accessory complex 8.806E-10 1.743E-8 1.208E-7 5.055E-7 9 24
30 GO:0034709 methylosome 1.452E-9 2.779E-8 1.926E-7 8.336E-7 7 12
31 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) 3.088E-9 5.719E-8 3.963E-7 1.773E-6 7 13
32 GO:0030532 small nuclear ribonucleoprotein complex 6.772E-9 1.215E-7 8.419E-7 3.887E-6 12 62
33 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) 7.555E-9 1.314E-7 9.108E-7 4.337E-6 6 9
34 GO:0033290 eukaryotic 48S preinitiation complex 1.116E-8 1.884E-7 1.306E-6 6.405E-6 7 15
35 GO:0071011 precatalytic spliceosome 1.571E-8 2.577E-7 1.786E-6 9.018E-6 8 23
36 GO:0097525 spliceosomal snRNP complex 1.649E-8 2.630E-7 1.823E-6 9.467E-6 11 54
37 GO:0005687 U4 snRNP 1.855E-8 2.877E-7 1.994E-6 1.065E-5 6 10
38 GO:0070993 translation preinitiation complex 1.947E-8 2.941E-7 2.038E-6 1.118E-5 7 16
39 GO:0034715 pICln-Sm protein complex 2.638E-8 3.882E-7 2.690E-6 1.514E-5 5 6
40 GO:0005685 U1 snRNP 3.249E-8 4.662E-7 3.231E-6 1.865E-5 7 17
41 GO:0005689 U12-type spliceosomal complex 4.730E-8 6.623E-7 4.590E-6 2.715E-5 8 26
42 GO:0005686 U2 snRNP 8.110E-8 1.108E-6 7.682E-6 4.655E-5 7 19
43 GO:0000314 organellar small ribosomal subunit 9.063E-8 1.182E-6 8.194E-6 5.202E-5 8 28
44 GO:0005763 mitochondrial small ribosomal subunit 9.063E-8 1.182E-6 8.194E-6 5.202E-5 8 28
45 GO:0005838 proteasome regulatory particle 1.803E-7 2.300E-6 1.594E-5 1.035E-4 7 21
46 GO:0005681 spliceosomal complex 2.080E-7 2.596E-6 1.799E-5 1.194E-4 17 173
47 GO:0016282 eukaryotic 43S preinitiation complex 4.034E-7 4.926E-6 3.414E-5 2.315E-4 6 15
48 GO:0005852 eukaryotic translation initiation factor 3 complex 6.337E-7 7.578E-6 5.252E-5 3.638E-4 6 16
49 GO:0044445 cytosolic part 8.486E-7 9.941E-6 6.890E-5 4.871E-4 19 235
50 GO:0034719 SMN-Sm protein complex 9.617E-7 1.104E-5 7.652E-5 5.520E-4 6 17
Show 45 more annotations

4: Human Phenotype [Display Chart] 783 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0003128 Lactic acidosis 4.538E-13 1.952E-10 1.413E-9 3.553E-10 19 148
2 HP:0002490 Increased CSF lactate 4.986E-13 1.952E-10 1.413E-9 3.904E-10 13 52
3 HP:0002878 Respiratory failure {has synonym type="layperson"} 1.984E-12 5.177E-10 3.749E-9 1.553E-9 14 71
4 HP:0001943 Hypoglycemia 6.912E-11 1.353E-8 9.798E-8 5.412E-8 14 91
5 HP:0001508 Failure to thrive 2.997E-10 4.693E-8 3.398E-7 2.347E-7 26 421
6 HP:0001427 Mitochondrial inheritance 4.182E-10 5.457E-8 3.951E-7 3.274E-7 12 69
7 HP:0001404 Hepatocellular necrosis 2.338E-9 2.615E-7 1.893E-6 1.830E-6 8 25
8 HP:0003546 Exercise intolerance 5.386E-9 5.272E-7 3.817E-6 4.217E-6 11 68
9 HP:0003812 Phenotypic variability 7.849E-9 6.829E-7 4.945E-6 6.146E-6 19 257
10 HP:0002151 Increased serum lactate 2.392E-8 1.873E-6 1.356E-5 1.873E-5 12 97
11 HP:0008316 Abnormal mitochondria in muscle tissue 2.642E-8 1.881E-6 1.362E-5 2.069E-5 7 22
12 HP:0000580 Pigmentary retinopathy 6.354E-8 4.146E-6 3.002E-5 4.975E-5 10 67
13 HP:0003593 Infantile onset {has synonym type="layperson"} 7.717E-8 4.648E-6 3.366E-5 6.043E-5 21 361
14 HP:0001639 Hypertrophic cardiomyopathy 1.005E-7 5.619E-6 4.068E-5 7.866E-5 12 110
15 HP:0002793 Abnormal pattern of respiration {has synonym type="layperson"} 2.057E-7 1.074E-5 7.775E-5 1.611E-4 6 18
16 HP:0001332 Dystonia 2.559E-7 1.252E-5 9.069E-5 2.004E-4 14 169
17 HP:0001251 Ataxia 2.921E-7 1.291E-5 9.351E-5 2.287E-4 19 321
18 HP:0006965 Acute necrotizing encephalopathy 2.969E-7 1.291E-5 9.351E-5 2.325E-4 6 19
19 HP:0007305 CNS demyelination 3.620E-7 1.492E-5 1.080E-4 2.835E-4 8 45
20 HP:0001347 Hyperreflexia 4.342E-7 1.700E-5 1.231E-4 3.400E-4 18 296
21 HP:0002181 Cerebral edema 4.597E-7 1.714E-5 1.241E-4 3.599E-4 7 32
22 HP:0000602 Ophthalmoplegia 7.774E-7 2.767E-5 2.004E-4 6.087E-4 9 67
23 HP:0001257 Spasticity 8.883E-7 3.024E-5 2.190E-4 6.955E-4 16 246
24 HP:0000998 Hypertrichosis 1.084E-6 3.537E-5 2.561E-4 8.488E-4 7 36
25 HP:0001423 X-linked dominant inheritance 1.350E-6 4.166E-5 3.017E-4 1.057E-3 10 92
26 HP:0004481 Progressive macrocephaly 1.383E-6 4.166E-5 3.017E-4 1.083E-3 6 24
27 HP:0001399 Hepatic failure 1.802E-6 5.227E-5 3.785E-4 1.411E-3 8 55
28 HP:0001324 Muscle weakness {has synonym type="layperson"} 2.544E-6 7.113E-5 5.151E-4 1.992E-3 13 175
29 HP:0000712 Emotional lability 3.121E-6 8.427E-5 6.102E-4 2.444E-3 8 59
30 HP:0000508 Ptosis 4.520E-6 1.180E-4 8.543E-4 3.539E-3 16 278
31 HP:0003202 Skeletal muscle atrophy 5.073E-6 1.281E-4 9.277E-4 3.972E-3 11 131
32 HP:0001254 Lethargy {has synonym type="layperson"} 5.402E-6 1.322E-4 9.571E-4 4.230E-3 9 84
33 HP:0002171 Gliosis 5.849E-6 1.388E-4 1.005E-3 4.580E-3 8 64
34 HP:0000486 Strabismus 6.658E-6 1.533E-4 1.110E-3 5.213E-3 17 321
35 HP:0008872 Feeding difficulties in infancy 8.129E-6 1.819E-4 1.317E-3 6.365E-3 12 165
36 HP:0001265 Hyporeflexia 1.251E-5 2.720E-4 1.969E-3 9.792E-3 13 202
37 HP:0002376 Developmental regression 1.287E-5 2.723E-4 1.972E-3 1.008E-2 8 71
38 HP:0002013 Vomiting {has synonym type="layperson"} 1.357E-5 2.796E-4 2.025E-3 1.062E-2 11 145
39 HP:0000639 Nystagmus 1.588E-5 3.188E-4 2.308E-3 1.243E-2 19 418
40 HP:0001259 Coma {has synonym type="layperson"} 5.114E-5 1.001E-3 7.249E-3 4.004E-2 7 63
41 HP:0001510 Growth delay {has synonym type="layperson"} 5.725E-5 1.093E-3 7.917E-3 4.483E-2 11 169
42 HP:0002415 Leukodystrophy 7.311E-5 1.363E-3 9.870E-3
5.725E-2
 6 46
43 HP:0000648 Optic atrophy 1.147E-4 2.089E-3 1.513E-2
8.985E-2
 12 215
44 HP:0001410 Decreased liver function {has synonym type="layperson"} 1.698E-4 3.021E-3 2.188E-2
1.329E-1
 5 34
45 HP:0003201 Rhabdomyolysis 1.885E-4 3.281E-3 2.375E-2
1.476E-1
 4 19
46 HP:0001962 Palpitations 2.842E-4 4.838E-3 3.503E-2
2.225E-1
 4 21
47 HP:0000407 Sensorineural hearing impairment 3.223E-4 5.369E-3 3.888E-2
2.523E-1
 14 314
48 HP:0000543 Optic disc pallor 3.459E-4 5.643E-3 4.086E-2
2.709E-1
 7 85
49 HP:0001644 Dilated cardiomyopathy 3.994E-4 6.382E-3 4.621E-2
3.127E-1
 7 87
50 HP:0006748 Adrenal pheochromocytoma 7.376E-4 1.031E-2
7.467E-2
5.775E-1
 2 3
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 1796 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0006204 embryonic lethality before implantation 6.431E-6 5.844E-3 4.717E-2 1.155E-2 13 169
2 MP:0011094 embryonic lethality before implantation, complete penetrance 6.508E-6 5.844E-3 4.717E-2 1.169E-2 12 144
3 MP:0011096 embryonic lethality between implantation and somite formation, complete penetrance 6.134E-5 3.672E-2
2.964E-1
1.102E-1
 15 270
4 MP:0010954 abnormal cellular respiration 9.427E-5 3.805E-2
3.071E-1
1.693E-1
 10 133
5 MP:0006036 abnormal mitochondrial physiology 1.059E-4 3.805E-2
3.071E-1
1.903E-1
 11 162

6: Domain [Display Chart] 1708 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR001353 Proteasome sua/b InterPro 3.118E-14 2.663E-11 2.136E-10 5.325E-11 11 19
2 PF00227 Proteasome Pfam 3.118E-14 2.663E-11 2.136E-10 5.325E-11 11 19
3 3.60.20.10 - Gene3D 9.330E-13 5.312E-10 4.261E-9 1.594E-9 11 24
4 IPR016050 Proteasome bsu CS InterPro 2.254E-11 9.626E-9 7.720E-8 3.850E-8 8 12
5 IPR029055 Ntn hydrolases N InterPro 6.059E-11 2.070E-8 1.660E-7 1.035E-7 11 33
6 PS51476 PROTEASOME BETA 2 PROSITE 6.991E-10 1.493E-7 1.197E-6 1.194E-6 7 11
7 IPR023333 Proteasome suB-type InterPro 6.991E-10 1.493E-7 1.197E-6 1.194E-6 7 11
8 PS00854 PROTEASOME BETA 1 PROSITE 6.991E-10 1.493E-7 1.197E-6 1.194E-6 7 11
9 PS51352 THIOREDOXIN 2 PROSITE 1.479E-9 2.807E-7 2.251E-6 2.526E-6 11 43
10 IPR001163 LSM dom euk/arc InterPro 3.008E-9 4.282E-7 3.434E-6 5.138E-6 8 19
11 SM00651 Sm SMART 3.008E-9 4.282E-7 3.434E-6 5.138E-6 8 19
12 PF01423 LSM Pfam 3.008E-9 4.282E-7 3.434E-6 5.138E-6 8 19
13 3.40.30.10 - Gene3D 1.025E-8 1.347E-6 1.081E-5 1.751E-5 16 122
14 IPR010920 LSM dom InterPro 1.201E-8 1.466E-6 1.176E-5 2.052E-5 8 22
15 IPR013766 Thioredoxin domain InterPro 1.382E-8 1.573E-6 1.262E-5 2.360E-5 10 41
16 PS51808 CHCH PROSITE 1.807E-8 1.929E-6 1.547E-5 3.087E-5 8 23
17 IPR000243 Pept T1A subB InterPro 2.065E-8 2.075E-6 1.664E-5 3.528E-5 6 10
18 IPR012336 Thioredoxin-like fold InterPro 3.213E-8 3.049E-6 2.446E-5 5.489E-5 16 132
19 PS00194 THIOREDOXIN 1 PROSITE 7.810E-7 7.021E-5 5.631E-4 1.334E-3 7 25
20 PF06747 CHCH Pfam 1.128E-6 9.172E-5 7.357E-4 1.926E-3 5 10
21 IPR010625 CHCH InterPro 1.128E-6 9.172E-5 7.357E-4 1.926E-3 5 10
22 PF00085 Thioredoxin Pfam 3.814E-6 2.961E-4 2.375E-3 6.515E-3 7 31
23 IPR033464 CSN8 PSD8 EIF3K InterPro 1.041E-5 7.405E-4 5.940E-3 1.777E-2 3 3
24 PS00558 EUKARYOTIC PORIN PROSITE 1.041E-5 7.405E-4 5.940E-3 1.777E-2 3 3
25 IPR023332 Proteasome suA-type InterPro 1.476E-5 8.402E-4 6.739E-3 2.521E-2 4 8
26 PS00388 PROTEASOME ALPHA 1 PROSITE 1.476E-5 8.402E-4 6.739E-3 2.521E-2 4 8
27 PS51475 PROTEASOME ALPHA 2 PROSITE 1.476E-5 8.402E-4 6.739E-3 2.521E-2 4 8
28 SM00948 Proteasome A N SMART 1.476E-5 8.402E-4 6.739E-3 2.521E-2 4 8
29 IPR000426 Proteasome asu N InterPro 1.476E-5 8.402E-4 6.739E-3 2.521E-2 4 8
30 PF10584 Proteasome A N Pfam 1.476E-5 8.402E-4 6.739E-3 2.521E-2 4 8
31 IPR011332 Ribosomal zn-bd InterPro 2.611E-5 1.393E-3 1.118E-2 4.459E-2 4 9
32 IPR002194 Chaperonin TCP-1 CS InterPro 2.611E-5 1.393E-3 1.118E-2 4.459E-2 4 9
33 PF10075 CSN8 PSD8 EIF3K Pfam 4.094E-5 1.974E-3 1.583E-2
6.993E-2
 3 4
34 IPR017998 Chaperone TCP-1 InterPro 4.276E-5 1.974E-3 1.583E-2
7.303E-2
 4 10
35 PS00995 TCP1 3 PROSITE 4.276E-5 1.974E-3 1.583E-2
7.303E-2
 4 10
36 PS00751 TCP1 2 PROSITE 4.276E-5 1.974E-3 1.583E-2
7.303E-2
 4 10
37 PS00750 TCP1 1 PROSITE 4.276E-5 1.974E-3 1.583E-2
7.303E-2
 4 10
38 3.30.260.10 - Gene3D 6.603E-5 2.892E-3 2.319E-2
1.128E-1
 4 11
39 IPR027410 TCP-1-like intermed InterPro 6.603E-5 2.892E-3 2.319E-2
1.128E-1
 4 11
40 IPR001925 Porin Euk InterPro 1.007E-4 3.583E-3 2.874E-2
1.720E-1
 3 5
41 PF10417 1-cysPrx C Pfam 1.007E-4 3.583E-3 2.874E-2
1.720E-1
 3 5
42 IPR023614 Porin dom InterPro 1.007E-4 3.583E-3 2.874E-2
1.720E-1
 3 5
43 2.40.160.10 - Gene3D 1.007E-4 3.583E-3 2.874E-2
1.720E-1
 3 5
44 IPR002379 ATPase proteolipid c-like dom InterPro 1.007E-4 3.583E-3 2.874E-2
1.720E-1
 3 5
45 PF01459 Porin 3 Pfam 1.007E-4 3.583E-3 2.874E-2
1.720E-1
 3 5
46 PF00137 ATP-synt C Pfam 1.007E-4 3.583E-3 2.874E-2
1.720E-1
 3 5
47 IPR019479 Peroxiredoxin C InterPro 1.007E-4 3.583E-3 2.874E-2
1.720E-1
 3 5
48 IPR027246 Porin Euk/Tom40 InterPro 1.007E-4 3.583E-3 2.874E-2
1.720E-1
 3 5
49 IPR027413 GROEL-like equatorial InterPro 1.901E-4 6.266E-3
5.026E-2
3.247E-1
 4 14
50 1.10.560.10 - Gene3D 1.901E-4 6.266E-3
5.026E-2
3.247E-1
 4 14
Show 45 more annotations

7: Pathway [Display Chart] 1129 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 477137 The citric acid (TCA) cycle and respiratory electron transport BioSystems: REACTOME 9.397E-43 1.061E-39 8.070E-39 1.061E-39 49 136
2 83098 Parkinson's disease BioSystems: KEGG 6.626E-41 3.740E-38 2.845E-37 7.480E-38 47 131
3 198860 Electron Transport Chain BioSystems: WikiPathways 3.596E-40 1.353E-37 1.030E-36 4.060E-37 43 106
4 83100 Huntington's disease BioSystems: KEGG 2.551E-39 7.201E-37 5.477E-36 2.880E-36 52 183
5 82942 Oxidative phosphorylation BioSystems: KEGG 3.481E-39 7.860E-37 5.979E-36 3.930E-36 46 133
6 105921 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. BioSystems: REACTOME 9.723E-38 1.830E-35 1.392E-34 1.098E-34 40 97
7 160962 Respiratory electron transport BioSystems: REACTOME 1.380E-28 2.226E-26 1.693E-25 1.558E-25 31 79
8 83097 Alzheimer's disease BioSystems: KEGG 5.131E-27 7.241E-25 5.508E-24 5.793E-24 40 168
9 PW:0000034 oxidative phosphorylation Pathway Ontology 1.956E-24 2.453E-22 1.866E-21 2.208E-21 24 52
10 83040 Proteasome BioSystems: KEGG 6.602E-22 7.453E-20 5.670E-19 7.453E-19 21 44
11 198870 Oxidative phosphorylation BioSystems: WikiPathways 8.384E-21 8.605E-19 6.545E-18 9.465E-18 23 62
12 M194 Proteasome Complex MSigDB C2 BIOCARTA (v5.1) 2.273E-20 2.139E-18 1.627E-17 2.567E-17 17 28
13 862188 Non-alcoholic fatty liver disease (NAFLD) BioSystems: KEGG 4.146E-20 3.601E-18 2.739E-17 4.681E-17 32 151
14 105983 HIV Infection BioSystems: REACTOME 4.717E-20 3.804E-18 2.894E-17 5.326E-17 38 225
15 477126 Cross-presentation of soluble exogenous antigens (endosomes) BioSystems: REACTOME 3.173E-19 2.389E-17 1.817E-16 3.583E-16 20 49
16 105686 Regulation of activated PAK-2p34 by proteasome mediated degradation BioSystems: REACTOME 5.162E-19 3.428E-17 2.608E-16 5.828E-16 20 50
17 106176 Regulation of ornithine decarboxylase (ODC) BioSystems: REACTOME 5.162E-19 3.428E-17 2.608E-16 5.828E-16 20 50
18 198786 Proteasome Degradation BioSystems: WikiPathways 6.168E-19 3.869E-17 2.943E-16 6.964E-16 22 65
19 105796 Ubiquitin-dependent degradation of Cyclin D BioSystems: REACTOME 8.288E-19 4.456E-17 3.389E-16 9.357E-16 20 51
20 105788 CDK-mediated phosphorylation and removal of Cdc6 BioSystems: REACTOME 8.288E-19 4.456E-17 3.389E-16 9.357E-16 20 51
21 105797 Ubiquitin-dependent degradation of Cyclin D1 BioSystems: REACTOME 8.288E-19 4.456E-17 3.389E-16 9.357E-16 20 51
22 106026 Vpu mediated degradation of CD4 BioSystems: REACTOME 1.314E-18 6.745E-17 5.131E-16 1.484E-15 20 52
23 105748 p53-Independent DNA Damage Response BioSystems: REACTOME 2.060E-18 8.946E-17 6.805E-16 2.326E-15 20 53
24 105747 p53-Independent G1/S DNA damage checkpoint BioSystems: REACTOME 2.060E-18 8.946E-17 6.805E-16 2.326E-15 20 53
25 105749 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A BioSystems: REACTOME 2.060E-18 8.946E-17 6.805E-16 2.326E-15 20 53
26 160939 Autodegradation of the E3 ubiquitin ligase COP1 BioSystems: REACTOME 2.060E-18 8.946E-17 6.805E-16 2.326E-15 20 53
27 105744 Stabilization of p53 BioSystems: REACTOME 3.193E-18 1.335E-16 1.016E-15 3.605E-15 20 54
28 105828 SCF-beta-TrCP mediated degradation of Emi1 BioSystems: REACTOME 4.897E-18 1.907E-16 1.450E-15 5.529E-15 20 55
29 187212 Destabilization of mRNA by AUF1 (hnRNP D0) BioSystems: REACTOME 4.897E-18 1.907E-16 1.450E-15 5.529E-15 20 55
30 106017 Vif-mediated degradation of APOBEC3G BioSystems: REACTOME 7.435E-18 2.798E-16 2.128E-15 8.394E-15 20 56
31 105836 Autodegradation of Cdh1 by Cdh1:APC/C BioSystems: REACTOME 8.289E-18 3.019E-16 2.296E-15 9.359E-15 21 64
32 105831 APC/C:Cdc20 mediated degradation of mitotic proteins BioSystems: REACTOME 1.072E-17 3.782E-16 2.877E-15 1.210E-14 22 73
33 105771 SCF(Skp2)-mediated degradation of p27/p21 BioSystems: REACTOME 1.118E-17 3.824E-16 2.909E-15 1.262E-14 20 57
34 477124 ER-Phagosome pathway BioSystems: REACTOME 1.195E-17 3.969E-16 3.019E-15 1.349E-14 21 65
35 105829 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins BioSystems: REACTOME 1.489E-17 4.803E-16 3.654E-15 1.681E-14 22 74
36 105741 p53-Dependent G1/S DNA damage checkpoint BioSystems: REACTOME 2.458E-17 7.304E-16 5.556E-15 2.775E-14 20 59
37 105743 p53-Dependent G1 DNA Damage Response BioSystems: REACTOME 2.458E-17 7.304E-16 5.556E-15 2.775E-14 20 59
38 105824 CDT1 association with the CDC6:ORC:origin complex BioSystems: REACTOME 2.458E-17 7.304E-16 5.556E-15 2.775E-14 20 59
39 105833 APC/C:Cdc20 mediated degradation of Securin BioSystems: REACTOME 3.434E-17 9.940E-16 7.561E-15 3.877E-14 21 68
40 106511 Degradation of beta-catenin by the destruction complex BioSystems: REACTOME 4.817E-17 1.360E-15 1.034E-14 5.439E-14 21 69
41 105685 Regulation of Apoptosis BioSystems: REACTOME 5.225E-17 1.439E-15 1.094E-14 5.899E-14 20 61
42 105740 G1/S DNA Damage Checkpoints BioSystems: REACTOME 7.528E-17 2.024E-15 1.539E-14 8.499E-14 20 62
43 105826 Regulation of APC/C activators between G1/S and early anaphase BioSystems: REACTOME 1.280E-16 3.361E-15 2.557E-14 1.445E-13 22 81
44 105835 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 BioSystems: REACTOME 1.757E-16 4.509E-15 3.430E-14 1.984E-13 21 73
45 105770 Cyclin E associated events during G1/S transition BioSystems: REACTOME 3.016E-16 7.567E-15 5.756E-14 3.405E-13 20 66
46 105783 Cyclin A:Cdk2-associated events at S phase entry BioSystems: REACTOME 4.196E-16 1.030E-14 7.834E-14 4.737E-13 20 67
47 160944 Regulation of mitotic cell cycle BioSystems: REACTOME 5.178E-16 1.218E-14 9.264E-14 5.846E-13 22 86
48 105825 APC/C-mediated degradation of cell cycle proteins BioSystems: REACTOME 5.178E-16 1.218E-14 9.264E-14 5.846E-13 22 86
49 576251 Activation of NF-kappaB in B Cells BioSystems: REACTOME 5.801E-16 1.310E-14 9.964E-14 6.550E-13 20 68
50 105821 Assembly of the pre-replicative complex BioSystems: REACTOME 5.801E-16 1.310E-14 9.964E-14 6.550E-13 20 68
Show 45 more annotations

8: Pubmed [Display Chart] 24135 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11042152 Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Pubmed 1.882E-84 4.541E-80 4.845E-79 4.541E-80 73 317
2 25147182 Quantitative Lys-¿-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. Pubmed 1.980E-79 2.390E-75 2.550E-74 4.780E-75 75 401
3 22623428 Proteomic analysis of ¿4�1 integrin adhesion complexes reveals ¿-subunit-dependent protein recruitment. Pubmed 5.302E-64 4.265E-60 4.550E-59 1.280E-59 69 491
4 21319273 An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. Pubmed 7.774E-62 4.691E-58 5.005E-57 1.876E-57 63 397
5 27499296 Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. Pubmed 1.451E-59 7.002E-56 7.471E-55 3.501E-55 62 409
6 20186120 A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. Pubmed 2.178E-52 8.762E-49 9.348E-48 5.257E-48 46 207
7 22190034 Global landscape of HIV-human protein complexes. Pubmed 1.702E-48 5.867E-45 6.259E-44 4.107E-44 56 457
8 21630459 Proteomic characterization of the human sperm nucleus. Pubmed 5.728E-47 1.728E-43 1.844E-42 1.382E-42 54 437
9 21081666 Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Pubmed 1.049E-44 2.813E-41 3.002E-40 2.532E-40 44 258
10 16196087 Large-scale analysis of the human ubiquitin-related proteome. Pubmed 1.306E-43 3.151E-40 3.362E-39 3.151E-39 46 313
11 21139048 Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Pubmed 2.218E-39 4.867E-36 5.193E-35 5.354E-35 39 233
12 20833797 Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Pubmed 2.197E-38 4.419E-35 4.715E-34 5.303E-34 28 81
13 23503661 Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Pubmed 1.649E-36 3.062E-33 3.266E-32 3.980E-32 26 71
14 21890473 A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Pubmed 1.910E-35 3.292E-32 3.513E-31 4.609E-31 35 209
15 22304920 PKC¿ promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Pubmed 2.248E-34 3.617E-31 3.859E-30 5.426E-30 30 136
16 24344204 TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. Pubmed 7.717E-34 1.164E-30 1.242E-29 1.862E-29 28 112
17 26641092 The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells. Pubmed 2.511E-33 3.565E-30 3.804E-29 6.061E-29 35 239
18 15635413 Nucleolar proteome dynamics. Pubmed 7.449E-33 9.987E-30 1.066E-28 1.798E-28 42 419
19 21906983 Systematic and quantitative assessment of the ubiquitin-modified proteome. Pubmed 9.654E-33 1.183E-29 1.262E-28 2.330E-28 33 207
20 8811196 Structure and functions of the 20S and 26S proteasomes. Pubmed 9.806E-33 1.183E-29 1.262E-28 2.367E-28 20 37
21 16130169 Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Pubmed 4.085E-32 4.695E-29 5.009E-28 9.860E-28 24 75
22 24337577 Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. Pubmed 5.573E-32 6.114E-29 6.523E-28 1.345E-27 32 198
23 14564014 Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. Pubmed 9.725E-32 1.021E-28 1.089E-27 2.347E-27 21 48
24 9079628 HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation. Pubmed 1.612E-31 1.441E-28 1.537E-27 3.890E-27 20 41
25 14550573 Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. Pubmed 1.612E-31 1.441E-28 1.537E-27 3.890E-27 20 41
26 12419264 The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing. Pubmed 1.612E-31 1.441E-28 1.537E-27 3.890E-27 20 41
27 10893419 Degradation of HIV-1 integrase by the N-end rule pathway. Pubmed 1.612E-31 1.441E-28 1.537E-27 3.890E-27 20 41
28 24999758 Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. Pubmed 2.007E-31 1.730E-28 1.846E-27 4.845E-27 41 425
29 12920286 Virology. Weapons of mutational destruction. Pubmed 3.055E-31 1.993E-28 2.126E-27 7.372E-27 20 42
30 9846577 Evidence for a newly discovered cellular anti-HIV-1 phenotype. Pubmed 3.055E-31 1.993E-28 2.126E-27 7.372E-27 20 42
31 14614829 The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G. Pubmed 3.055E-31 1.993E-28 2.126E-27 7.372E-27 20 42
32 12830140 DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses. Pubmed 3.055E-31 1.993E-28 2.126E-27 7.372E-27 20 42
33 12719574 Comprehensive investigation of the molecular defect in vif-deficient human immunodeficiency virus type 1 virions. Pubmed 3.055E-31 1.993E-28 2.126E-27 7.372E-27 20 42
34 9811770 An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein. Pubmed 3.055E-31 1.993E-28 2.126E-27 7.372E-27 20 42
35 12750511 Hypermutation of HIV-1 DNA in the absence of the Vif protein. Pubmed 3.055E-31 1.993E-28 2.126E-27 7.372E-27 20 42
36 12914693 Death by deamination: a novel host restriction system for HIV-1. Pubmed 3.055E-31 1.993E-28 2.126E-27 7.372E-27 20 42
37 12840737 Good to CU. Pubmed 3.055E-31 1.993E-28 2.126E-27 7.372E-27 20 42
38 17314511 Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. Pubmed 3.943E-31 2.504E-28 2.671E-27 9.515E-27 32 210
39 22119785 Defining human ERAD networks through an integrative mapping strategy. Pubmed 5.168E-31 2.911E-28 3.106E-27 1.247E-26 30 173
40 14528300 The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif. Pubmed 5.670E-31 2.911E-28 3.106E-27 1.368E-26 20 43
41 12970355 The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity. Pubmed 5.670E-31 2.911E-28 3.106E-27 1.368E-26 20 43
42 12808466 Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. Pubmed 5.670E-31 2.911E-28 3.106E-27 1.368E-26 20 43
43 12809610 DNA deamination mediates innate immunity to retroviral infection. Pubmed 5.670E-31 2.911E-28 3.106E-27 1.368E-26 20 43
44 12808465 The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA. Pubmed 5.670E-31 2.911E-28 3.106E-27 1.368E-26 20 43
45 14527406 HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. Pubmed 5.670E-31 2.911E-28 3.106E-27 1.368E-26 20 43
46 14528301 HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation. Pubmed 5.670E-31 2.911E-28 3.106E-27 1.368E-26 20 43
47 14557625 The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity. Pubmed 5.670E-31 2.911E-28 3.106E-27 1.368E-26 20 43
48 12167863 Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Pubmed 1.032E-30 5.189E-28 5.535E-27 2.490E-26 20 44
49 21963094 Global identification of modular cullin-RING ligase substrates. Pubmed 1.269E-30 6.251E-28 6.669E-27 3.063E-26 30 178
50 17323924 Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Pubmed 3.239E-30 1.563E-27 1.668E-26 7.817E-26 20 46
Show 45 more annotations

9: Interaction [Display Chart] 6355 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:VCAM1 VCAM1 interactions 1.725E-34 5.581E-31 5.209E-30 1.096E-30 68 447
2 int:HUWE1 HUWE1 interactions 1.756E-34 5.581E-31 5.209E-30 1.116E-30 69 462
3 int:NDUFA4 NDUFA4 interactions 2.805E-32 5.943E-29 5.547E-28 1.783E-28 43 163
4 int:MRPL58 MRPL58 interactions 1.013E-31 1.609E-28 1.502E-27 6.435E-28 50 244
5 int:NDUFS3 NDUFS3 interactions 4.355E-29 5.536E-26 5.167E-25 2.768E-25 39 150
6 int:C15orf48 C15orf48 interactions 5.911E-28 6.260E-25 5.844E-24 3.756E-24 35 121
7 int:NDUFA12 NDUFA12 interactions 4.476E-26 4.064E-23 3.793E-22 2.845E-22 27 68
8 int:PSMB9 PSMB9 interactions 2.824E-25 2.243E-22 2.094E-21 1.795E-21 27 72
9 int:UQCRC2 UQCRC2 interactions 4.252E-25 3.002E-22 2.802E-21 2.702E-21 34 134
10 int:SDHB SDHB interactions 1.033E-23 6.497E-21 6.065E-20 6.565E-20 28 89
11 int:PARK2 PARK2 interactions 1.125E-23 6.497E-21 6.065E-20 7.147E-20 54 422
12 int:NDUFA9 NDUFA9 interactions 1.627E-22 8.617E-20 8.043E-19 1.034E-18 26 80
13 int:RPN1 RPN1 interactions 5.687E-22 2.780E-19 2.595E-18 3.614E-18 33 153
14 int:NDUFS4 NDUFS4 interactions 7.509E-21 3.409E-18 3.182E-17 4.772E-17 24 74
15 int:PSMB8 PSMB8 interactions 9.441E-21 4.000E-18 3.733E-17 5.999E-17 22 59
16 int:GOLT1B GOLT1B interactions 4.009E-20 1.592E-17 1.486E-16 2.547E-16 33 174
17 int:PSMA4 PSMA4 interactions 1.241E-19 4.640E-17 4.331E-16 7.888E-16 26 101
18 int:VDAC2 VDAC2 interactions 2.192E-19 7.740E-17 7.225E-16 1.393E-15 28 124
19 int:HDAC5 HDAC5 interactions 4.537E-19 1.517E-16 1.416E-15 2.883E-15 44 351
20 int:PSMC2 PSMC2 interactions 7.939E-19 2.523E-16 2.355E-15 5.045E-15 30 153
21 int:ADRM1 ADRM1 interactions 1.612E-18 4.879E-16 4.554E-15 1.025E-14 21 64
22 int:PSMA3 PSMA3 interactions 5.409E-18 1.562E-15 1.458E-14 3.437E-14 38 276
23 int:VDAC3 VDAC3 interactions 1.144E-17 3.028E-15 2.827E-14 7.268E-14 24 98
24 int:ATP5F1 ATP5F1 interactions 1.144E-17 3.028E-15 2.827E-14 7.268E-14 24 98
25 int:PSMB7 PSMB7 interactions 1.774E-17 4.509E-15 4.209E-14 1.127E-13 22 80
26 int:NDUFA11 NDUFA11 interactions 2.956E-17 7.224E-15 6.743E-14 1.878E-13 17 41
27 int:U2AF2 U2AF2 interactions 3.185E-17 7.497E-15 6.998E-14 2.024E-13 42 357
28 int:PSMA6 PSMA6 interactions 4.885E-17 1.109E-14 1.035E-13 3.105E-13 27 138
29 int:PSMA8 PSMA8 interactions 6.575E-17 1.441E-14 1.345E-13 4.179E-13 16 36
30 int:MPV17 MPV17 interactions 6.951E-17 1.472E-14 1.374E-13 4.417E-13 18 50
31 int:PSMD14 PSMD14 interactions 1.018E-16 2.086E-14 1.948E-13 6.468E-13 24 107
32 int:PSMB6 PSMB6 interactions 1.168E-16 2.319E-14 2.165E-13 7.422E-13 21 77
33 int:PSMB2 PSMB2 interactions 1.271E-16 2.447E-14 2.284E-13 8.075E-13 22 87
34 int:MTCH2 MTCH2 interactions 1.685E-16 3.149E-14 2.939E-13 1.071E-12 20 69
35 int:LAMTOR3 LAMTOR3 interactions 2.080E-16 3.777E-14 3.526E-13 1.322E-12 21 79
36 int:ATF2 ATF2 interactions 2.920E-16 5.154E-14 4.811E-13 1.855E-12 32 216
37 int:PSMD6 PSMD6 interactions 4.611E-16 7.919E-14 7.392E-13 2.930E-12 22 92
38 int:NDUFB9 NDUFB9 interactions 7.137E-16 1.194E-13 1.114E-12 4.536E-12 18 56
39 int:ATP5C1 ATP5C1 interactions 8.962E-16 1.433E-13 1.338E-12 5.695E-12 24 117
40 int:COQ9 COQ9 interactions 9.022E-16 1.433E-13 1.338E-12 5.733E-12 29 181
41 int:PSMA5 PSMA5 interactions 1.341E-15 2.025E-13 1.890E-12 8.519E-12 25 131
42 int:PSMB1 PSMB1 interactions 1.347E-15 2.025E-13 1.890E-12 8.559E-12 24 119
43 int:PSMB3 PSMB3 interactions 1.370E-15 2.025E-13 1.890E-12 8.709E-12 21 86
44 int:NDUFA8 NDUFA8 interactions 1.528E-15 2.207E-13 2.060E-12 9.713E-12 19 67
45 int:SUMO4 SUMO4 interactions 4.016E-15 5.671E-13 5.293E-12 2.552E-11 20 80
46 int:PSMD12 PSMD12 interactions 7.522E-15 1.031E-12 9.622E-12 4.780E-11 21 93
47 int:PSMA2 PSMA2 interactions 7.623E-15 1.031E-12 9.622E-12 4.845E-11 24 128
48 int:NDUFB5 NDUFB5 interactions 7.833E-15 1.037E-12 9.680E-12 4.978E-11 14 32
49 int:DDOST DDOST interactions 1.114E-14 1.445E-12 1.349E-11 7.079E-11 20 84
50 int:PSMB4 PSMB4 interactions 1.487E-14 1.890E-12 1.764E-11 9.450E-11 21 96
Show 45 more annotations

10: Cytoband [Display Chart] 304 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6p21.3-p21.1 6p21.3-p21.1 1.355E-4 4.120E-2
2.594E-1
 4.120E-2 2 2

11: Transcription Factor Binding Site [Display Chart] 487 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$ELK1 02 V$ELK1 02 2.620E-8 1.276E-5 8.634E-5 1.276E-5 21 185
2 GGAANCGGAANY UNKNOWN GGAANCGGAANY UNKNOWN 8.853E-8 2.156E-5 1.459E-4 4.312E-5 14 88
3 V$GABP B V$GABP B 1.002E-5 1.627E-3 1.101E-2 4.881E-3 17 184
4 V$NRF2 01 V$NRF2 01 1.881E-5 2.290E-3 1.550E-2 9.161E-3 17 193
5 TMTCGCGANR UNKNOWN TMTCGCGANR UNKNOWN 1.735E-4 1.689E-2
1.143E-1
8.447E-2
 11 109
6 TGACCTTG V$SF1 Q6 TGACCTTG V$SF1 Q6 3.505E-4 2.572E-2
1.741E-1
1.707E-1
 15 200
7 V$CETS1P54 01 V$CETS1P54 01 3.698E-4 2.572E-2
1.741E-1
1.801E-1
 15 201
8 V$SF1 Q6 V$SF1 Q6 4.330E-4 2.636E-2
1.783E-1
2.109E-1
 15 204
9 V$ERR1 Q2 V$ERR1 Q2 5.876E-4 3.179E-2
2.151E-1
2.861E-1
 15 210
Show 4 more annotations

12: Gene Family [Display Chart] 114 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 690 Proteasome genenames.org 2.281E-26 2.600E-24 1.383E-23 2.600E-24 20 43
2 646 Mitochondrial ribosomal proteins genenames.org 4.745E-26 2.705E-24 1.438E-23 5.410E-24 24 79
3 1150 NADH:ubiquinone oxidoreductase supernumerary subunits genenames.org 1.505E-24 5.719E-23 3.041E-22 1.716E-22 17 30
4 416 F-type ATPases|Mitochondrial complex V: ATP synthase subunits genenames.org 8.630E-15 2.460E-13 1.308E-12 9.839E-13 10 18
5 644 F-type ATPases|Mitochondrial complex V: ATP synthase subunits genenames.org 1.800E-14 4.104E-13 2.182E-12 2.052E-12 10 19
6 445 Oligosaccharyltransferase complex subunits genenames.org 5.734E-9 1.089E-7 5.793E-7 6.537E-7 6 12
7 1121 Eukaryotic translation initiation factor 3 genenames.org 1.053E-8 1.714E-7 9.115E-7 1.200E-6 6 13
8 643 Mitochondrial complex IV: cytochrome c oxidase subunits genenames.org 1.552E-7 2.212E-6 1.176E-5 1.769E-5 6 19
9 306 Voltage dependent anion channels genenames.org 2.626E-6 3.326E-5 1.769E-4 2.994E-4 3 3
10 489 Coiled-coil-helix-coiled-coil-helix domain containing genenames.org 4.288E-6 4.888E-5 2.599E-4 4.888E-4 4 9
11 642 Mitochondrial complex III: ubiquinol-cytochrome c reductase complex subunits genenames.org 7.068E-6 7.325E-5 3.895E-4 8.058E-4 4 10
12 1040 Ragulator complex genenames.org 2.572E-5 2.444E-4 1.300E-3 2.933E-3 3 5
13 587 Chaperonins genenames.org 4.350E-5 3.610E-4 1.920E-3 4.959E-3 4 15
14 726 RNA polymerase subunits genenames.org 4.433E-5 3.610E-4 1.920E-3 5.053E-3 5 29
15 953 Peroxiredoxins genenames.org 5.092E-5 3.870E-4 2.058E-3 5.805E-3 3 6
16 956 Prefoldin subunits genenames.org 1.397E-4 9.952E-4 5.292E-3 1.592E-2 3 8
17 645 Mitochondrial respiratory chain complex assembly factors genenames.org 2.169E-4 1.455E-3 7.736E-3 2.473E-2 5 40
18 415 V-type ATPases genenames.org 2.586E-4 1.638E-3 8.711E-3 2.948E-2 4 23
19 567 Glutathione S-transferases genenames.org 3.615E-4 2.169E-3 1.154E-2 4.121E-2 4 25
20 538 WD repeat domain containing|Dyneins, cytoplasmic genenames.org 6.776E-4 3.862E-3 2.054E-2
7.725E-2
 3 13
21 402 Anaphase promoting complex |Tetratricopeptide repeat domain containing genenames.org 8.536E-4 4.634E-3 2.464E-2
9.731E-2
 3 14
22 641 Mitochondrial complex II: succinate dehydrogenase subunits genenames.org 1.126E-3 5.833E-3 3.102E-2
1.283E-1
 2 4
23 728 S ribosomal proteins genenames.org 1.202E-3 5.958E-3 3.168E-2
1.370E-1
 4 34
24 132 Aminoacyl tRNA synthetases, Class II genenames.org 2.159E-3 1.026E-2
5.454E-2
2.461E-1
 3 19
25 692 Protein disulfide isomerases genenames.org 2.904E-3 1.324E-2
7.041E-2
3.310E-1
 3 21
26 1361 Armadillo repeat containing|NineTeen complex genenames.org 3.833E-3 1.618E-2
8.606E-2
4.369E-1
 2 7
27 1229 Translocase of outer mitochondrial membrane complex genenames.org 3.833E-3 1.618E-2
8.606E-2
4.369E-1
 2 7
28 39 Actin related protein 2/3 complex genenames.org 6.451E-3 2.452E-2
1.304E-1
7.355E-1
 2 9
29 1306 ASAP complex|SIN3 histone deacetylase complex genenames.org 6.451E-3 2.452E-2
1.304E-1
7.355E-1
 2 9
30 932 COP9 signalosome genenames.org 6.451E-3 2.452E-2
1.304E-1
7.355E-1
 2 9
31 979 COMM domain containing genenames.org 7.991E-3 2.847E-2
1.514E-1
9.110E-1
 2 10
32 635 LYR motif containing|NADH:ubiquinone oxidoreductase supernumerary subunits genenames.org 7.991E-3 2.847E-2
1.514E-1
9.110E-1
 2 10
33 357 ARF GTPase family genenames.org 8.865E-3 3.062E-2
1.629E-1
1.000E0
 3 31
34 482 Charged multivesicular body proteins|ESCRT-III associated factors genenames.org 9.678E-3 3.245E-2
1.726E-1
1.000E0
 2 11
35 362 WD repeat domain containing genenames.org 1.104E-2 3.596E-2
1.912E-1
1.000E0
 9 262
36 391 RAN family GTPases genenames.org 1.385E-2 4.268E-2
2.269E-1
1.000E0
 1 1
37 712 Class II Cys-based phosphatases|Acid phosphatases genenames.org 1.385E-2 4.268E-2
2.269E-1
1.000E0
 1 1
38 772 Trafficking protein particle complex genenames.org 1.558E-2 4.555E-2
2.422E-1
1.000E0
 2 14
39 657 Myosin light chains|EF-hand domain containing genenames.org 1.558E-2 4.555E-2
2.422E-1
1.000E0
 2 14
Show 34 more annotations

13: Coexpression [Display Chart] 6228 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5936 Genes encoding proteins involved in oxidative phosphorylation. MSigDB H: Hallmark Gene Sets (v5.1) 2.262E-71 1.409E-67 1.312E-66 1.409E-67 71 200
2 M15112 Genes that comprise the mitochondria gene module MSigDB C2: CGP Curated Gene Sets (v5.1) 1.014E-59 3.158E-56 2.941E-55 6.315E-56 65 217
3 M9433 Mitochondrial genes; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.968E-55 1.447E-51 1.347E-50 4.340E-51 79 429
4 M9577 Mitochondrial genes MSigDB C2: CGP Curated Gene Sets (v5.1) 6.894E-48 1.073E-44 9.997E-44 4.293E-44 74 447
5 M13713 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 13. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.821E-42 2.269E-39 2.113E-38 1.134E-38 48 172
6 M11197 Housekeeping genes identified as expressed across 19 normal tissues. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.964E-42 3.077E-39 2.866E-38 1.846E-38 65 389
7 M4929 Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those at day 3 post-vaccination. MSigDB C7: Immunologic Signatures (v5.1) 2.580E-40 2.295E-37 2.138E-36 1.607E-36 49 200
8 M18264 Genes involved in oxidative phosphorylation; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.144E-39 2.448E-36 2.280E-35 1.958E-35 36 87
9 M9788 Genes up-regulated in differentiating C2C12 cells (myoblasts) upon expression of PPARGC1A [GeneID=10891] off an adenoviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.324E-36 3.684E-33 3.431E-32 3.316E-32 61 420
10 M1859 Genes down-regulated in ALL (acute lymphoblastic leukemia) blasts after 1 week of treatment with glucocorticoids. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.352E-35 8.422E-33 7.844E-32 8.422E-32 57 362
11 M5926 A subgroup of genes regulated by MYC - version 1 (v1). MSigDB H: Hallmark Gene Sets (v5.1) 2.686E-35 1.521E-32 1.416E-31 1.673E-31 45 200
12 M6202 Genes down-regulated in polymorphonuclear leukocytes (9h): control versus infection by A. phagocytophilum. MSigDB C7: Immunologic Signatures (v5.1) 4.468E-34 2.141E-31 1.994E-30 2.783E-30 44 200
13 GSE45837 WT VS GFI1 KO PDC DN Genes down-regulated in plasmacytoid dendritic cells: wildtype versus GFI1 [GeneID=2672] knockout. MSigDB C7: Immunologic Signatures (v5.1) 4.468E-34 2.141E-31 1.994E-30 2.783E-30 44 200
14 M4467 Genes down-regulated in comparison of neutrophils versusl monocytes. MSigDB C7: Immunologic Signatures (v5.1) 7.203E-33 3.204E-30 2.985E-29 4.486E-29 43 200
15 M10986 Marker genes down-regulated in the 'unannotated' subclass of hepatocellular carcinoma (HCC) samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.362E-32 9.808E-30 9.135E-29 1.471E-28 42 193
16 M4465 Genes down-regulated in comparison of neutrophils versus dendritic cells (DC). MSigDB C7: Immunologic Signatures (v5.1) 1.125E-31 4.378E-29 4.078E-28 7.005E-28 42 200
17 M7079 The 'core ESC-like gene module': genes coordinately up-regulated in a compendium of mouse embryonic stem cells (ESC) which are shared with the human ESC-like module. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.884E-30 1.423E-27 1.325E-26 2.419E-26 50 335
18 M4927 Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee before vaccination versus that after the vaccination. MSigDB C7: Immunologic Signatures (v5.1) 2.879E-28 9.961E-26 9.278E-25 1.793E-24 39 199
19 M12591 Genes up-regulated by 3 h of euglycemic hyperinsulinemic clamp in the vastus lateralis muscle of healthy lean subjects. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.748E-28 1.556E-25 1.450E-24 2.957E-24 54 442
20 M3597 Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 48 h. MSigDB C7: Immunologic Signatures (v5.1) 4.806E-27 1.497E-24 1.394E-23 2.993E-23 38 200
21 M2336 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 17. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.106E-26 6.247E-24 5.819E-23 1.312E-22 36 181
22 M6204 Genes up-regulated in polymorphonuclear leukocytes (24h): control versus infection by A. phagocytophilum. MSigDB C7: Immunologic Signatures (v5.1) 6.345E-26 1.718E-23 1.600E-22 3.952E-22 37 200
23 M4473 Genes up-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated neutrophils. MSigDB C7: Immunologic Signatures (v5.1) 6.345E-26 1.718E-23 1.600E-22 3.952E-22 37 200
24 M18854 Genes down-regulated in BJUB cells (B-lymphoma) in response to rapamycin [PubChem=6610346] treatment. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.783E-26 2.279E-23 2.123E-22 5.470E-22 40 245
25 M4463 Genes down-regulated in comparison of monocytes cultured for 1 day versus those cultured for 7 days. MSigDB C7: Immunologic Signatures (v5.1) 8.086E-25 1.946E-22 1.812E-21 5.036E-21 36 200
26 M19745 Genes down-regulated in mature plasma cells compared with plasmablastic B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.122E-25 1.946E-22 1.812E-21 5.059E-21 43 308
27 M4525 Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus stimulated CD4 [GeneID=920] Th1 cells at 48 h. MSigDB C7: Immunologic Signatures (v5.1) 9.941E-24 2.211E-21 2.060E-20 6.192E-20 35 200
28 GSE26030 TH1 VS TH17 RESTIMULATED DAY5 POST POLARIZATION UP Genes up-regulated in T helper cells 5 days post polarization and stimulated with anti-CD3 and anti-CD28: Th1 versus Th17. MSigDB C7: Immunologic Signatures (v5.1) 9.941E-24 2.211E-21 2.060E-20 6.192E-20 35 200
29 M4533 Genes down-regulated in comparison of unstimulated NK cells versus those stimulated with IL2 [GeneID=3600] at 16 h. MSigDB C7: Immunologic Signatures (v5.1) 1.178E-22 2.530E-20 2.357E-19 7.338E-19 34 200
30 GSE25123 WT VS PPARG KO MACROPHAGE DN Genes down-regulated in bone marrow-derived macrophages: wildtype versus PPARG [GeneID=5468] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.345E-21 2.792E-19 2.600E-18 8.376E-18 33 200
31 GSE16266 CTRL VS HEATSHOCK AND LPS STIM MEF UP Genes up-regulated inmouse embryonic fibroblasts (MEF): control versus LPS and heat shock. MSigDB C7: Immunologic Signatures (v5.1) 1.478E-20 2.789E-18 2.597E-17 9.202E-17 32 200
32 M3023 Genes up-regulated in comparison of effector CD8 T cells at the peak expansion phase (day8) versus those at contraction (day 15) after LCMV-Armstrong infection. MSigDB C7: Immunologic Signatures (v5.1) 1.478E-20 2.789E-18 2.597E-17 9.202E-17 32 200
33 M3604 Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 48 h after stimulation with antigen-B7-1. MSigDB C7: Immunologic Signatures (v5.1) 1.478E-20 2.789E-18 2.597E-17 9.202E-17 32 200
34 M1865 Up-regulated genes in the subpopulation of invasive PyMT cells (breast cancer) compared to the general population of PyMT cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.047E-19 1.918E-17 1.786E-16 6.521E-16 41 374
35 M3582 Up-regulated genes in melanoma tumous that developed metastatic disease compared to primary melanoma that did not. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.153E-19 2.051E-17 1.910E-16 7.179E-16 31 198
36 GSE19941 IL10 KO VS IL10 KO AND NFKBP50 KO LPS STIM MACROPHAGE DN Genes down-regulated in macrophages stimulated by LPS: IL10 [GeneID=3586] knockout versus IL10 and NFKB1 [GeneID=3586;4790] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.561E-19 2.701E-17 2.515E-16 9.722E-16 31 200
37 M1858 Down-regulated genes in A2780 cells (ovarian cancer) treated with 17AAG [PubChem=6440175], a chemical with anticancer properties. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.090E-18 1.834E-16 1.708E-15 6.787E-15 21 79
38 M3299 Genes down-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) 1 day after stimulation with YF17D vaccine versus PBMC 21 days after the stimulation. MSigDB C7: Immunologic Signatures (v5.1) 1.184E-18 1.940E-16 1.807E-15 7.374E-15 30 198
39 M3192 Genes up-regulated in comparison of IgD- peripheral blood B cells versus dark zone germinal center B cells. MSigDB C7: Immunologic Signatures (v5.1) 1.370E-18 2.188E-16 2.038E-15 8.534E-15 30 199
40 M3678 Genes down-regulated in comparison of regulatory T cell (Treg) from uninfected mice versus regulatory T cell (Treg) from mice infected with S. mansoni. MSigDB C7: Immunologic Signatures (v5.1) 1.585E-18 2.407E-16 2.242E-15 9.869E-15 30 200
41 M5619 Genes down-regulated in comparison of CD4 [GeneID=920] T cells treated with TGFB1 [GeneID=7040] and IL6 [GeneID=3569] versus those treated with TGFB1 [GeneID=7040], IL6 [GeneID=3569] and IL23A [GeneID=51561]. MSigDB C7: Immunologic Signatures (v5.1) 1.585E-18 2.407E-16 2.242E-15 9.869E-15 30 200
42 M10236 Genes up-regulated in biphasic (mixed) vs epithelial subtypes of malignant peritoneal mesothelioma. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.772E-18 2.628E-16 2.447E-15 1.104E-14 36 305
43 M18436 Up-regulated genes in hepatocellular carcinoma (HCC) subclass G3, defined by unsupervised clustering. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.734E-18 3.959E-16 3.688E-15 1.703E-14 29 188
44 M16740 Up-regulated genes in both rectal and colon carcinoma compared to normal mucosa samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.174E-17 1.662E-15 1.548E-14 7.312E-14 34 285
45 M5592 Genes down-regulated in comparison of central memory CD4 [GeneID=920] T cells versus Th2 cells. MSigDB C7: Immunologic Signatures (v5.1) 1.544E-17 1.962E-15 1.828E-14 9.615E-14 29 200
46 M4503 Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus unstimulatd dendritic cells (DC). MSigDB C7: Immunologic Signatures (v5.1) 1.544E-17 1.962E-15 1.828E-14 9.615E-14 29 200
47 GSE41867 LCMV ARMSTRONG VS CLONE13 DAY6 EFFECTOR CD8 TCELL UP Genes up-regulated in CD8 T effector cells at day 6 of chronic infection: LCMV-Armstrong versus LCMV-Clone 13. MSigDB C7: Immunologic Signatures (v5.1) 1.544E-17 1.962E-15 1.828E-14 9.615E-14 29 200
48 M4410 Genes down-regulated in comparison of unstimulated memory CD4 [GeneID=920] CD8 T cells versus stimulated CD4 [GeneID=920] CD8 T cells. MSigDB C7: Immunologic Signatures (v5.1) 1.544E-17 1.962E-15 1.828E-14 9.615E-14 29 200
49 M4461 Genes down-regulated in comparison of monocytes cultured for 0 days versus those cultured for 7 days. MSigDB C7: Immunologic Signatures (v5.1) 1.544E-17 1.962E-15 1.828E-14 9.615E-14 29 200
50 M12016 Genes up-regulated in epithelial ovarian cancer (EOC) biopsies: invasive (TOV) vs low malignant potential (LMP) tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.578E-17 4.457E-15 4.152E-14 2.229E-13 23 117
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 1851 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Lungmap Mouse e14.5 Epithelial (GSE52583) Top 500 All Mouse Lung E14.5 Epithelial top 500 Lungmap Mouse Single Cell (Lungmap.net) 8.126E-57 1.504E-53 1.218E-52 1.504E-53 83 446
2 Lungmap Mouse e14.5 Epithelial (GSE52583) Top 500 Cluster 1 Mouse Lung E14.5 Epithelial top 500 c1 Lungmap Mouse Single Cell (Lungmap.net) 9.312E-37 8.619E-34 6.982E-33 1.724E-33 36 96
3 Facebase RNAseq ratio e10.5 MandibularArch vs MaxillaryArch 1000 K2 FacebaseRNAseq ratio e10.5 MandibularArch vs MaxillaryArch top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 8.225E-28 5.075E-25 4.111E-24 1.522E-24 51 378
4 Lungmap Mouse e16.5 Epithelial (GSE52583) Top 500 All Mouse Lung E16.5 Epithelial GSE52583 top 500 Lungmap Mouse Single Cell (Lungmap.net) 1.368E-27 6.329E-25 5.127E-24 2.532E-24 54 435
5 Lungmap Mouse e14.5 Epithelial (GSE52583) Top 500 Cluster 4 Mouse Lung E14.5 Epithelial top 500 c4 Lungmap Mouse Single Cell (Lungmap.net) 1.632E-24 6.041E-22 4.894E-21 3.020E-21 29 112
6 Lungmap Mouse e16.5 Matrix fibroblast SubClass Intermediate Fibroblast Top 500 All Mouse Lung E16.5 Intermediate Fibroblast top 500 Lungmap Mouse Single Cell (Lungmap.net) 3.725E-22 1.149E-19 9.309E-19 6.895E-19 47 420
7 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 k1 1000 dev lower uro neuro e14.5 PelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.393E-20 6.328E-18 5.126E-17 4.429E-17 39 310
8 Facebase RNAseq ratio e10.5 MandibularArch vs MaxillaryArch 500 FacebaseRNAseq ratio e10.5 MandibularArch vs MaxillaryArch top-relative-expression-ranked 500 FaceBase_RNAseq 4.127E-20 9.550E-18 7.736E-17 7.640E-17 48 491
9 Lungmap Mouse e16.5 Matrix fibroblast SubClass Intermediate Fibroblast Top 500 Cluster 4 Mouse Lung E16.5 Matrix Fibroblast Intermediate Fibroblast c4 Lungmap Mouse Single Cell (Lungmap.net) 5.157E-20 1.061E-17 8.592E-17 9.546E-17 21 67
10 Facebase RNAseq ratio e10.5 MandibularArch vs MaxillaryArch 500 K2 FacebaseRNAseq ratio e10.5 MandibularArch vs MaxillaryArch top-relative-expression-ranked 500 k-means-cluster#2 FaceBase_RNAseq 2.490E-19 4.609E-17 3.734E-16 4.609E-16 30 181
11 Lungmap Mouse e16.5 Epithelial (GSE52583) Top 500 Cluster 0 Mouse Lung E16.5 Epithelial GSE52583 top 500 c0 Lungmap Mouse Single Cell (Lungmap.net) 3.233E-18 5.440E-16 4.407E-15 5.984E-15 24 114
12 Lungmap Mouse e16.5 Matrix fibroblast SubClass Mature fibroblast 2 Top 500 Cluster 3 Mouse Lung E16.5 Matrix Fibroblast Mature fibroblast 2 c3 Lungmap Mouse Single Cell (Lungmap.net) 1.147E-16 1.769E-14 1.433E-13 2.123E-13 18 62
13 gudmap developingGonad e11.5 testes k5 1000 DevelopingGonad e11.5 testes emap-3226 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.025E-16 5.731E-14 4.643E-13 7.450E-13 43 498
14 Lungmap Mouse e16.5 Epithelial (GSE52583) Top 500 Cluster 3 Mouse Lung E16.5 Epithelial GSE52583 top 500 c3 Lungmap Mouse Single Cell (Lungmap.net) 2.921E-15 3.863E-13 3.129E-12 5.408E-12 16 53
15 gudmap developingGonad e14.5 testes 1000 k5 DevelopingGonad e14.5 testes emap-6710 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.014E-14 1.252E-12 1.014E-11 1.877E-11 38 429
16 Facebase RNAseq e10.5 Lateral Nasal Eminence 2500 K5 FacebaseRNAseq e10.5 Lateral Nasal Eminence top-relative-expression-ranked 2500 k-means-cluster#5 FaceBase_RNAseq 1.837E-14 2.126E-12 1.722E-11 3.401E-11 40 483
17 Lungmap Mouse e18.5 Epithelial (GSE52583) SubClass Clara Top 500 Cluster 1 Mouse Lung E18.5 Epithelial Clara c1 Lungmap Mouse Single Cell (Lungmap.net) 3.861E-14 4.204E-12 3.405E-11 7.146E-11 12 27
18 gudmap developingGonad e14.5 testes 500 k4 DevelopingGonad e14.5 testes emap-6710 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.528E-13 2.600E-11 2.106E-10 4.680E-10 24 184
19 gudmap developingGonad e11.5 testes 500 DevelopingGonad e11.5 testes emap-3226 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.675E-13 4.554E-11 3.689E-10 8.653E-10 36 437
20 gudmap developingGonad P2 testes 1000 k2 DevelopingGonad P2 testes emap-30171 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.543E-13 5.130E-11 4.156E-10 1.026E-9 32 349
21 Lungmap Mouse e18.5 Epithelial (GSE52583) SubClass ciliated Top 500 Cluster 1 Mouse Lung E18.5 Epithelial Ciliated c1 Lungmap Mouse Single Cell (Lungmap.net) 7.082E-13 5.959E-11 4.827E-10 1.311E-9 12 33
22 Lungmap Mouse e16.5 Myofibro SubClass Migrating Myofibroblast Top 500 Cluster 2 Mouse Lung E16.5 Myofibroblast Migrating Myofibroblast c2 Lungmap Mouse Single Cell (Lungmap.net) 7.082E-13 5.959E-11 4.827E-10 1.311E-9 12 33
23 gudmap developingGonad e16.5 testes 1000 k3 DevelopingGonad e16.5 testes emap-8444 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 9.320E-13 7.501E-11 6.076E-10 1.725E-9 33 378
24 neurons SubClass GLRA2-hi Top 500 Cluster 2 neurons SubClass GLRA2-hi Top 500 Cluster 2 Brain Map - Barres 1.679E-12 1.295E-10 1.049E-9 3.107E-9 14 54
25 GSM605776 500 gamma delta T cells, Tgd.vg1+vd6+.Th, TCRd+ Vg1.1+ Vd6.3+, Thymus, avg-2 Immgen.org, GSE15907 3.216E-12 2.381E-10 1.929E-9 5.953E-9 30 328
26 GSM605775 500 gamma delta T cells, Tgd.vg1+vd6+.Th, TCRd+ Vd6.3+ Vg1.1+, Thymus, avg-1 Immgen.org, GSE15907 3.645E-12 2.595E-10 2.102E-9 6.746E-9 29 308
27 Facebase RNAseq e10.5 Maxillary Arch 2500 K2 FacebaseRNAseq e10.5 Maxillary Arch top-relative-expression-ranked 2500 k-means-cluster#2 FaceBase_RNAseq 1.164E-11 7.977E-10 6.462E-9 2.154E-8 32 391
28 gudmap developingGonad e12.5 testes k4 500 DevelopingGonad e12.5 testes emap-29069 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.420E-11 9.387E-10 7.604E-9 2.628E-8 25 241
29 neurons SubClass TAC1-hi Top 500 Cluster 3 neurons SubClass TAC1-hi Top 500 Cluster 3 Brain Map - Barres 1.881E-11 1.200E-9 9.724E-9 3.481E-8 12 42
30 Lungmap Mouse e16.5 Epithelial SubClass Proliferative AT2 Progenitor Top 500 Cluster 2 Mouse Lung E16.5 Epithelial Proliferative AT2 Progenitor c2 Lungmap Mouse Single Cell (Lungmap.net) 9.878E-11 6.095E-9 4.937E-8 1.828E-7 13 59
31 12Dp Top 500 Cluster 4 12Dp Top 500 Cluster 4 Brain Map - Allen iN 1.128E-10 6.737E-9 5.458E-8 2.088E-7 11 38
32 gudmap developingGonad e11.5 testes and mesonephros 500 DevelopingGonad e11.5 testes and mesonephros emap-3226 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.832E-10 1.060E-8 8.587E-8 3.392E-7 32 435
33 gudmap developingGonad e18.5 testes 1000 k3 DevelopingGonad e18.5 testes emap-11164 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 8.480E-10 4.756E-8 3.853E-7 1.570E-6 28 362
34 Lungmap Mouse e14.5 Epithelial (GSE52583) Top 500 Cluster 3 Mouse Lung E14.5 Epithelial top 500 c3 Lungmap Mouse Single Cell (Lungmap.net) 9.480E-10 5.161E-8 4.181E-7 1.755E-6 9 26
35 Facebase RNAseq e8.5 Floor Plate 1000 K3 FacebaseRNAseq e8.5 Floor Plate top-relative-expression-ranked 1000 k-means-cluster#3 FaceBase_RNAseq 1.233E-9 6.408E-8 5.191E-7 2.282E-6 25 297
36 gudmap developingGonad e11.5 testes and mesonephros k4 500 DevelopingGonad e11.5 testes and mesonephros emap-3226 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.246E-9 6.408E-8 5.191E-7 2.307E-6 22 231
37 Lungmap Mouse e16.5 Myeloid SubClass Proliferative Myeloid Top 500 Cluster 1 Mouse Lung E16.5 Myeloid Proliferative Myeloid c1 Lungmap Mouse Single Cell (Lungmap.net) 1.393E-9 6.968E-8 5.644E-7 2.578E-6 11 47
38 PP HSC 2500 K1 PP HSC top-relative-expression-ranked 2500 k-means-cluster#1 PCBC 1.494E-9 7.279E-8 5.897E-7 2.766E-6 31 447
39 gudmap developingGonad e11.5 testes k3 500 DevelopingGonad e11.5 testes emap-3226 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.824E-9 1.815E-7 1.470E-6 7.079E-6 17 144
40 26Dn Top 500 Cluster 4 26Dn Top 500 Cluster 4 Brain Map - Allen iN 4.422E-9 2.046E-7 1.658E-6 8.184E-6 11 52
41 26Dn SubClass 26Dn 2 Top 500 Cluster 3 26Dn SubClass 26Dn 2 Top 500 Cluster 3 Brain Map - Allen iN 9.281E-9 4.190E-7 3.394E-6 1.718E-5 12 69
42 Facebase RNAseq ratio e9.5 MaxillaryArch vs Mandibular 2500 K4 FacebaseRNAseq ratio e9.5 MaxillaryArch vs Mandibular top-relative-expression-ranked 2500 k-means-cluster#4 FaceBase_RNAseq 9.747E-9 4.296E-7 3.480E-6 1.804E-5 23 281
43 ratio ECTO vs SC 2500 K2 ratio induced-Ectoderm vs StemCell top-relative-expression-ranked 2500 k-means-cluster#2 PCBC 2.114E-8 9.099E-7 7.371E-6 3.912E-5 28 419
44 Lungmap Mouse e16.5 Matrix fibroblast SubClass Intermediate Fibroblast Top 500 Cluster 1 Mouse Lung E16.5 Matrix Fibroblast Intermediate Fibroblast c1 Lungmap Mouse Single Cell (Lungmap.net) 3.116E-8 1.311E-6 1.062E-5 5.767E-5 9 37
45 GSM791119 500 Stem Cells, SC.GMP.BM, Lineage- sca1- ckithi CD34+ FcgRhi, Bone marrow, avg-3 Immgen.org, GSE15907 4.198E-8 1.727E-6 1.399E-5 7.771E-5 27 406
46 Facebase RNAseq ratio e10.5 MandibularArch vs MaxillaryArch 500 K4 FacebaseRNAseq ratio e10.5 MandibularArch vs MaxillaryArch top-relative-expression-ranked 500 k-means-cluster#4 FaceBase_RNAseq 6.095E-8 2.453E-6 1.987E-5 1.128E-4 17 173
47 gudmap developingGonad P2 testes 500 k3 DevelopingGonad P2 testes emap-30171 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.963E-8 3.136E-6 2.541E-5 1.474E-4 15 136
48 gudmap developingGonad e11.5 testes k2 500 DevelopingGonad e11.5 testes emap-3226 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.208E-7 4.659E-6 3.774E-5 2.236E-4 18 203
49 gudmap developingGonad e12.5 testes 500 DevelopingGonad e12.5 testes emap-29069 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.578E-7 5.961E-6 4.829E-5 2.921E-4 26 406
50 Lungmap Mouse e16.5 Matrix fibroblast SubClass Intermediate Fibroblast Top 500 Cluster 3 Mouse Lung E16.5 Matrix Fibroblast Intermediate Fibroblast c3 Lungmap Mouse Single Cell (Lungmap.net) 1.880E-7 6.962E-6 5.640E-5 3.481E-4 13 107
Show 45 more annotations

15: Computational [Display Chart] 569 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MORF SOD1 Neighborhood of SOD1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 7.917E-49 4.505E-46 3.118E-45 4.505E-46 73 254
2 MORF RAN Neighborhood of RAN MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.774E-48 5.048E-46 3.494E-45 1.010E-45 72 248
3 module 114 Genes in module 114 MSigDb: C4 - CM: Cancer Modules 1.032E-46 1.957E-44 1.355E-43 5.872E-44 79 327
4 module 83 Genes in module 83 MSigDb: C4 - CM: Cancer Modules 1.084E-45 1.329E-43 9.201E-43 6.171E-43 76 307
5 MORF CSNK2B Neighborhood of CSNK2B MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.265E-45 1.329E-43 9.201E-43 7.196E-43 71 261
6 module 151 Genes in module 151 MSigDb: C4 - CM: Cancer Modules 1.402E-45 1.329E-43 9.201E-43 7.976E-43 76 308
7 MORF ERH Neighborhood of ERH MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.492E-36 5.277E-34 3.653E-33 3.694E-33 43 106
8 MORF DAP3 Neighborhood of DAP3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 7.997E-35 5.688E-33 3.937E-32 4.550E-32 52 179
9 module 152 Genes in module 152 MSigDb: C4 - CM: Cancer Modules 6.438E-34 4.070E-32 2.818E-31 3.663E-31 44 123
10 MORF RAD23A Neighborhood of RAD23A MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.958E-33 1.683E-31 1.165E-30 1.683E-30 65 320
11 module 62 Genes in module 62 MSigDb: C4 - CM: Cancer Modules 4.741E-33 2.452E-31 1.697E-30 2.697E-30 38 88
12 MORF HDAC1 Neighborhood of HDAC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.154E-32 1.021E-30 7.070E-30 1.226E-29 55 226
13 MORF PSMC1 Neighborhood of PSMC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.775E-32 2.090E-30 1.447E-29 2.717E-29 48 166
14 MORF BUB3 Neighborhood of BUB3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.950E-32 2.418E-30 1.674E-29 3.385E-29 58 260
15 MORF RAD21 Neighborhood of RAD21 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.855E-31 7.037E-30 4.871E-29 1.056E-28 47 162
16 MORF PPP1CA Neighborhood of PPP1CA MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.549E-31 1.973E-29 1.366E-28 3.157E-28 45 149
17 MORF AP2M1 Neighborhood of AP2M1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 9.251E-31 3.096E-29 2.143E-28 5.264E-28 51 203
18 MORF G22P1 Neighborhood of G22P1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.046E-28 3.305E-27 2.288E-26 5.950E-26 43 149
19 MORF SKP1A Neighborhood of SKP1A MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.038E-28 1.209E-26 8.370E-26 2.297E-25 46 180
20 MORF ANP32B Neighborhood of ANP32B MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.674E-27 7.607E-26 5.266E-25 1.521E-24 45 178
21 MORF PRKAR1A Neighborhood of PRKAR1A MSigDb: C4 - CGN: Cancer Gene Neighborhood 7.157E-25 1.939E-23 1.342E-22 4.072E-22 38 136
22 MORF MAP2K2 Neighborhood of MAP2K2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.657E-24 1.463E-22 1.013E-21 3.219E-21 36 126
23 MORF RAD23B Neighborhood of RAD23B MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.090E-23 2.696E-22 1.866E-21 6.200E-21 40 164
24 MORF FBL Neighborhood of FBL MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.273E-23 1.250E-21 8.654E-21 3.000E-20 35 125
25 MORF DEK Neighborhood of DEK MSigDb: C4 - CGN: Cancer Gene Neighborhood 8.258E-23 1.828E-21 1.265E-20 4.699E-20 46 235
26 GNF2 RAN Neighborhood of RAN MSigDb: C4 - CGN: Cancer Gene Neighborhood 8.354E-23 1.828E-21 1.265E-20 4.753E-20 29 80
27 MORF PRDX3 Neighborhood of PRDX3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.262E-22 2.660E-21 1.841E-20 7.181E-20 29 81
28 MORF AP3D1 Neighborhood of AP3D1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.592E-22 7.300E-21 5.053E-20 2.044E-19 34 123
29 GNF2 XRCC5 Neighborhood of XRCC5 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.657E-22 9.137E-21 6.324E-20 2.650E-19 26 64
30 MORF EIF3S2 Neighborhood of EIF3S2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.637E-22 1.259E-20 8.714E-20 3.777E-19 44 224
31 MORF PPP6C Neighborhood of PPP6C MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.727E-21 5.006E-20 3.465E-19 1.552E-18 29 89
32 MORF UBE2I Neighborhood of UBE2I MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.281E-21 9.391E-20 6.500E-19 3.005E-18 42 213
33 MORF CTBP1 Neighborhood of CTBP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.243E-21 1.076E-19 7.452E-19 3.552E-18 36 152
34 MORF XRCC5 Neighborhood of XRCC5 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.966E-20 8.311E-19 5.753E-18 2.826E-17 41 214
35 module 22 Genes in module 22 MSigDb: C4 - CM: Cancer Modules 1.401E-19 2.277E-18 1.576E-17 7.970E-17 21 45
36 MORF HAT1 Neighborhood of HAT1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.907E-19 4.594E-18 3.180E-17 1.654E-16 35 159
37 module 91 Genes in module 91 MSigDb: C4 - CM: Cancer Modules 7.687E-19 1.182E-17 8.183E-17 4.374E-16 19 37
38 GCM NPM1 Neighborhood of NPM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.503E-18 2.251E-17 1.558E-16 8.553E-16 29 109
39 MORF HDAC2 Neighborhood of HDAC2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.032E-18 2.934E-17 2.031E-16 1.156E-15 43 260
40 MORF EI24 Neighborhood of EI24 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.062E-18 2.934E-17 2.031E-16 1.174E-15 32 138
41 module 28 Genes in module 28 MSigDb: C4 - CM: Cancer Modules 2.597E-17 3.604E-16 2.494E-15 1.478E-14 17 32
42 GCM ACTG1 Neighborhood of ACTG1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 7.723E-17 1.046E-15 7.242E-15 4.394E-14 28 115
43 MORF ATOX1 Neighborhood of ATOX1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 9.597E-17 1.270E-15 8.791E-15 5.461E-14 23 73
44 MORF NME2 Neighborhood of NME2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.618E-16 2.093E-15 1.449E-14 9.209E-14 31 148
45 MORF GNB1 Neighborhood of GNB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.684E-16 3.393E-15 2.349E-14 1.527E-13 42 282
46 MORF PSMC2 Neighborhood of PSMC2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.040E-16 3.760E-15 2.603E-14 1.730E-13 26 102
47 MORF MBD4 Neighborhood of MBD4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.629E-16 4.394E-15 3.041E-14 2.065E-13 23 77
48 MORF PTPN11 Neighborhood of PTPN11 MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.091E-16 6.035E-15 4.177E-14 2.897E-13 25 95
49 GCM APEX1 Neighborhood of APEX1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 8.441E-16 9.802E-15 6.785E-14 4.803E-13 26 106
50 MORF RAB1A Neighborhood of RAB1A MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.269E-15 1.444E-14 9.994E-14 7.219E-13 33 181
Show 45 more annotations

16: MicroRNA [Display Chart] 1207 annotations before applied cutoff / 19844 genes in category

No results to display

17: Drug [Display Chart] 21513 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C066340 tolcapone CTD 8.393E-53 1.806E-48 1.906E-47 1.806E-48 69 322
2 C099555 CD 437 CTD 4.251E-49 4.573E-45 4.826E-44 9.146E-45 57 216
3 CID000135411 CD437 Stitch 5.749E-34 4.123E-30 4.351E-29 1.237E-29 44 203
4 CID000001062 AC1L1AN5 Stitch 7.123E-27 3.831E-23 4.043E-22 1.532E-22 38 204
5 CID000447920 ubiquinols Stitch 1.177E-24 5.064E-21 5.344E-20 2.532E-20 27 95
6 CID000119058 AC1L3O4T Stitch 4.562E-24 1.636E-20 1.726E-19 9.813E-20 38 242
7 CID000000928 reduced diphosphopyridine nucleotide Stitch 3.810E-23 1.171E-19 1.236E-18 8.196E-19 43 342
8 D007538 Isoniazid CTD 2.216E-22 5.959E-19 6.289E-18 4.767E-18 25 92
9 DB00157 NADH Drug Bank 1.278E-20 2.768E-17 2.921E-16 2.749E-16 28 144
10 CID000005102 NSC115907 Stitch 1.286E-20 2.768E-17 2.921E-16 2.768E-16 36 266
11 D064730 Dexrazoxane CTD 7.903E-20 1.546E-16 1.631E-15 1.700E-15 27 140
12 D010695 Phlorhizin CTD 1.499E-19 2.688E-16 2.837E-15 3.225E-15 33 234
13 CID000000612 lactate Stitch 4.063E-18 6.723E-15 7.096E-14 8.741E-14 43 461
14 C080703 SK&F 83959 CTD 1.052E-17 1.617E-14 1.707E-13 2.264E-13 26 153
15 CID000000703 flavin adenine dinucleotide sodium Stitch 2.936E-17 4.211E-14 4.444E-13 6.317E-13 37 356
16 D015647 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine CTD 4.552E-17 6.121E-14 6.460E-13 9.793E-13 26 162
17 C041517 dibenzo(a,l)pyrene CTD 1.899E-16 2.403E-13 2.536E-12 4.086E-12 34 315
18 CID000000152 NSC333308 Stitch 3.162E-16 3.779E-13 3.988E-12 6.803E-12 22 116
19 C063855 microcystin RR CTD 3.473E-16 3.933E-13 4.150E-12 7.472E-12 20 91
20 D006820 Hyaluronic Acid CTD 6.815E-16 7.331E-13 7.736E-12 1.466E-11 27 197
21 CID000000525 malate Stitch 1.218E-15 1.247E-12 1.316E-11 2.619E-11 28 219
22 CID000002204 AC1L1D5O Stitch 1.133E-14 1.108E-11 1.169E-10 2.437E-10 23 152
23 CID000001693 4-hydroxynonenal Stitch 4.293E-14 4.016E-11 4.238E-10 9.237E-10 38 471
24 C009618 O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate CTD 8.050E-14 7.216E-11 7.615E-10 1.732E-9 25 201
25 CID000061668 boronic acid Stitch 1.657E-13 1.426E-10 1.505E-9 3.566E-9 17 82
26 CID011840981 DB08515 Stitch 1.745E-13 1.444E-10 1.524E-9 3.755E-9 9 13
27 2036 DN Baclofen (R,S) [1134-47-0]; Down 200; 18.8uM; HL60; HG-U133A Broad Institute CMAP 3.617E-13 2.882E-10 3.041E-9 7.781E-9 24 196
28 CID006439229 Glidobactin A Stitch 4.807E-13 3.693E-10 3.898E-9 1.034E-8 9 14
29 CID000001060 pyruvic acid Stitch 1.181E-12 8.763E-10 9.248E-9 2.541E-8 34 424
30 CID000001110 succinate Stitch 2.193E-12 1.573E-9 1.660E-8 4.718E-8 30 339
31 CID000025959 Prussian blue Stitch 3.207E-12 2.226E-9 2.349E-8 6.900E-8 21 161
32 CID006476006 beta-lactone Stitch 3.448E-12 2.318E-9 2.447E-8 7.418E-8 16 84
33 C031280 pyrazole CTD 5.231E-12 3.410E-9 3.599E-8 1.125E-7 23 202
34 D013605 T-2 Toxin CTD 6.134E-12 3.881E-9 4.096E-8 1.320E-7 30 353
35 C002741 N-nitrosomorpholine CTD 7.668E-12 4.713E-9 4.974E-8 1.650E-7 29 333
36 D010882 Piperonyl Butoxide CTD 8.810E-12 5.265E-9 5.556E-8 1.895E-7 32 406
37 CID005458193 CID5458193 Stitch 1.046E-11 6.082E-9 6.419E-8 2.250E-7 16 90
38 CID000004591 AC1L1IIA Stitch 1.165E-11 6.598E-9 6.963E-8 2.507E-7 21 172
39 CID011840940 esy Stitch 2.041E-11 1.126E-8 1.188E-7 4.391E-7 9 19
40 C561722 EGFR tyrosine kinase inhibitor 324674 CTD 2.685E-11 1.444E-8 1.524E-7 5.777E-7 7 9
41 CID000033558 azide Stitch 2.800E-11 1.469E-8 1.550E-7 6.023E-7 21 180
42 D015741 Metribolone CTD 3.396E-11 1.739E-8 1.836E-7 7.305E-7 30 378
43 CID000001111 succinyl-coenzyme A Stitch 4.628E-11 2.316E-8 2.444E-7 9.957E-7 20 166
44 CID000000710 riboflavin 5'-phosphate Stitch 7.975E-11 3.899E-8 4.115E-7 1.716E-6 20 171
45 614 UP monastrol; Up 200; 20uM; MCF7; HG-U133A Broad Institute CMAP 8.664E-11 4.142E-8 4.371E-7 1.864E-6 21 191
46 D004298 Dopamine CTD 9.809E-11 4.587E-8 4.841E-7 2.110E-6 23 233
47 D014266 Trientine CTD 1.014E-10 4.642E-8 4.899E-7 2.182E-6 17 120
48 CID003522484 AC1MRR4B Stitch 1.875E-10 8.404E-8 8.870E-7 4.034E-6 21 199
49 CID000000283 formate Stitch 3.621E-10 1.590E-7 1.678E-6 7.789E-6 24 271
50 D019259 Lamivudine CTD 3.908E-10 1.681E-7 1.774E-6 8.407E-6 21 207
Show 45 more annotations

18: Disease [Display Chart] 2230 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C2936907 NADH:Q(1) Oxidoreductase deficiency DisGeNET Curated 6.264E-8 1.397E-4 1.158E-3 1.397E-4 7 20
2 256000 LEIGH SYNDROME; LS OMIM 7.999E-7 4.589E-4 3.803E-3 1.784E-3 6 18
3 cv:C1838979 Mitochondrial complex I deficiency Clinical Variations 7.999E-7 4.589E-4 3.803E-3 1.784E-3 6 18
4 umls:C0342776 Nicotinamide adenine dinucleotide coenzyme Q reductase deficiency DisGeNET BeFree 1.046E-6 4.589E-4 3.803E-3 2.332E-3 8 41
5 252010 MITOCHONDRIAL COMPLEX I DEFICIENCY OMIM 1.150E-6 4.589E-4 3.803E-3 2.564E-3 6 19
6 umls:C1838979 MITOCHONDRIAL COMPLEX I DEFICIENCY DisGeNET Curated 1.391E-6 4.589E-4 3.803E-3 3.102E-3 7 30
7 umls:C0162670 Mitochondrial Myopathies DisGeNET Curated 1.441E-6 4.589E-4 3.803E-3 3.212E-3 9 57
8 cv:C0023264 Leigh's disease Clinical Variations 1.001E-5 2.791E-3 2.313E-2 2.233E-2 5 16
9 umls:C0023264 Leigh Disease DisGeNET Curated 2.507E-5 6.213E-3
5.149E-2
5.592E-2
 9 80
10 umls:C1838951 LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY DisGeNET Curated 1.218E-4 2.604E-2
2.158E-1
2.716E-1
 4 14
11 umls:C0013502 Echinococcosis DisGeNET Curated 1.284E-4 2.604E-2
2.158E-1
2.864E-1
 5 26
12 umls:C0751651 Mitochondrial Diseases DisGeNET Curated 2.484E-4 4.373E-2
3.624E-1
5.540E-1
 10 131
13 umls:C0268237 Cytochrome-c Oxidase Deficiency DisGeNET Curated 2.549E-4 4.373E-2
3.624E-1
5.685E-1
 6 46
14 umls:C0024667 Animal Mammary Neoplasms DisGeNET Curated 3.778E-4 4.975E-2
4.123E-1
8.425E-1
 10 138
15 612359 COWDEN-LIKE SYNDROME OMIM 3.792E-4 4.975E-2
4.123E-1
8.457E-1
 2 2
16 cv:C0342786 Mitochondrial trifunctional protein deficiency Clinical Variations 3.792E-4 4.975E-2
4.123E-1
8.457E-1
 2 2
17 609015 TRIFUNCTIONAL PROTEIN DEFICIENCY OMIM 3.792E-4 4.975E-2
4.123E-1
8.457E-1
 2 2
Show 12 more annotations