Toppgene analysis for aggregated_1964_log, IC5, negative side

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1: GO: Molecular Function [Display Chart] 182 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1901681 sulfur compound binding 1.120E-4 1.031E-2
5.966E-2
 2.039E-2 5 260
2 GO:0044548 S100 protein binding 2.588E-4 1.031E-2
5.966E-2
 4.709E-2 2 13
3 GO:0048156 tau protein binding 3.015E-4 1.031E-2
5.966E-2
5.488E-2
 2 14
4 GO:0001618 virus receptor activity 3.089E-4 1.031E-2
5.966E-2
5.621E-2
 3 71
5 GO:0043295 glutathione binding 3.475E-4 1.031E-2
5.966E-2
6.325E-2
 2 15
6 GO:0005229 intracellular calcium activated chloride channel activity 3.967E-4 1.031E-2
5.966E-2
7.220E-2
 2 16
7 GO:1900750 oligopeptide binding 3.967E-4 1.031E-2
5.966E-2
7.220E-2
 2 16
8 GO:0042277 peptide binding 1.702E-3 3.077E-2
1.780E-1
3.097E-1
 4 278
9 GO:0001664 G-protein coupled receptor binding 1.702E-3 3.077E-2
1.780E-1
3.097E-1
 4 278
10 GO:0004364 glutathione transferase activity 1.816E-3 3.077E-2
1.780E-1
3.305E-1
 2 34
11 GO:0046911 metal chelating activity 1.860E-3 3.077E-2
1.780E-1
3.385E-1
 1 1
12 GO:0033218 amide binding 2.499E-3 3.686E-2
2.132E-1
4.548E-1
 4 309
13 GO:0001105 RNA polymerase II transcription coactivator activity 2.633E-3 3.686E-2
2.132E-1
4.792E-1
 2 41
14 GO:0022839 ion gated channel activity 3.164E-3 4.113E-2
2.379E-1
5.758E-1
 2 45
Show 9 more annotations

2: GO: Biological Process [Display Chart] 1614 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031349 positive regulation of defense response 1.756E-5 1.823E-2
1.452E-1
 2.835E-2 7 429
2 GO:0018916 nitrobenzene metabolic process 2.259E-5 1.823E-2
1.452E-1
 3.647E-2 2 4
3 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 5.367E-5 2.888E-2
2.300E-1
8.663E-2
 6 346
4 GO:0071560 cellular response to transforming growth factor beta stimulus 8.515E-5 2.980E-2
2.373E-1
1.374E-1
 5 231
5 GO:0071559 response to transforming growth factor beta 9.232E-5 2.980E-2
2.373E-1
1.490E-1
 5 235
6 GO:1900047 negative regulation of hemostasis 1.372E-4 3.016E-2
2.402E-1
2.215E-1
 3 51
7 GO:0030195 negative regulation of blood coagulation 1.372E-4 3.016E-2
2.402E-1
2.215E-1
 3 51
8 GO:0050819 negative regulation of coagulation 1.540E-4 3.016E-2
2.402E-1
2.485E-1
 3 53
9 GO:0060137 maternal process involved in parturition 1.682E-4 3.016E-2
2.402E-1
2.715E-1
 2 10
10 GO:0042178 xenobiotic catabolic process 2.053E-4 3.314E-2
2.639E-1
3.314E-1
 2 11
11 GO:0061045 negative regulation of wound healing 2.698E-4 3.572E-2
2.845E-1
4.354E-1
 3 64
12 GO:1903034 regulation of response to wounding 3.060E-4 3.572E-2
2.845E-1
4.939E-1
 6 476
13 GO:0042493 response to drug 3.236E-4 3.572E-2
2.845E-1
5.223E-1
 6 481
14 GO:0001666 response to hypoxia 3.501E-4 3.572E-2
2.845E-1
5.650E-1
 5 313
15 GO:0036293 response to decreased oxygen levels 3.986E-4 3.572E-2
2.845E-1
6.434E-1
 5 322
16 GO:0090026 positive regulation of monocyte chemotaxis 4.452E-4 3.572E-2
2.845E-1
7.185E-1
 2 16
17 GO:0035810 positive regulation of urine volume 4.452E-4 3.572E-2
2.845E-1
7.185E-1
 2 16
18 GO:0035690 cellular response to drug 4.834E-4 3.572E-2
2.845E-1
7.802E-1
 3 78
19 GO:0002693 positive regulation of cellular extravasation 5.039E-4 3.572E-2
2.845E-1
8.133E-1
 2 17
20 GO:0070482 response to oxygen levels 5.040E-4 3.572E-2
2.845E-1
8.135E-1
 5 339
21 GO:1903036 positive regulation of response to wounding 5.057E-4 3.572E-2
2.845E-1
8.161E-1
 4 189
22 GO:0050727 regulation of inflammatory response 5.459E-4 3.572E-2
2.845E-1
8.810E-1
 5 345
23 GO:0090083 regulation of inclusion body assembly 6.320E-4 3.572E-2
2.845E-1
1.000E0
 2 19
24 GO:0010544 negative regulation of platelet activation 6.320E-4 3.572E-2
2.845E-1
1.000E0
 2 19
25 GO:1901655 cellular response to ketone 7.109E-4 3.572E-2
2.845E-1
1.000E0
 3 89
26 GO:1901216 positive regulation of neuron death 7.584E-4 3.572E-2
2.845E-1
1.000E0
 3 91
27 GO:1900046 regulation of hemostasis 7.829E-4 3.572E-2
2.845E-1
1.000E0
 3 92
28 GO:0030193 regulation of blood coagulation 7.829E-4 3.572E-2
2.845E-1
1.000E0
 3 92
29 GO:0007567 parturition 8.506E-4 3.572E-2
2.845E-1
1.000E0
 2 22
30 GO:0090025 regulation of monocyte chemotaxis 8.506E-4 3.572E-2
2.845E-1
1.000E0
 2 22
31 GO:1901685 glutathione derivative metabolic process 8.506E-4 3.572E-2
2.845E-1
1.000E0
 2 22
32 GO:1901687 glutathione derivative biosynthetic process 8.506E-4 3.572E-2
2.845E-1
1.000E0
 2 22
33 GO:0048871 multicellular organismal homeostasis 8.542E-4 3.572E-2
2.845E-1
1.000E0
 5 381
34 GO:0050818 regulation of coagulation 8.860E-4 3.572E-2
2.845E-1
1.000E0
 3 96
35 GO:0071347 cellular response to interleukin-1 9.130E-4 3.572E-2
2.845E-1
1.000E0
 3 97
36 GO:0035809 regulation of urine volume 9.305E-4 3.572E-2
2.845E-1
1.000E0
 2 23
37 GO:0030336 negative regulation of cell migration 9.706E-4 3.572E-2
2.845E-1
1.000E0
 4 225
38 GO:0070841 inclusion body assembly 1.101E-3 3.572E-2
2.845E-1
1.000E0
 2 25
39 GO:2000146 negative regulation of cell motility 1.158E-3 3.572E-2
2.845E-1
1.000E0
 4 236
40 GO:0090181 regulation of cholesterol metabolic process 1.285E-3 3.572E-2
2.845E-1
1.000E0
 2 27
41 GO:0002691 regulation of cellular extravasation 1.285E-3 3.572E-2
2.845E-1
1.000E0
 2 27
42 GO:0042537 benzene-containing compound metabolic process 1.382E-3 3.572E-2
2.845E-1
1.000E0
 2 28
43 GO:0055074 calcium ion homeostasis 1.404E-3 3.572E-2
2.845E-1
1.000E0
 5 426
44 GO:0048520 positive regulation of behavior 1.586E-3 3.572E-2
2.845E-1
1.000E0
 2 30
45 GO:0046718 viral entry into host cell 1.686E-3 3.572E-2
2.845E-1
1.000E0
 3 120
46 GO:0019058 viral life cycle 1.736E-3 3.572E-2
2.845E-1
1.000E0
 5 447
47 GO:0052126 movement in host environment 1.809E-3 3.572E-2
2.845E-1
1.000E0
 3 123
48 GO:0051828 entry into other organism involved in symbiotic interaction 1.809E-3 3.572E-2
2.845E-1
1.000E0
 3 123
49 GO:0052192 movement in environment of other organism involved in symbiotic interaction 1.809E-3 3.572E-2
2.845E-1
1.000E0
 3 123
50 GO:0044409 entry into host 1.809E-3 3.572E-2
2.845E-1
1.000E0
 3 123
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 136 annotations before applied cutoff / 19172 genes in category

No results to display

4: Human Phenotype [Display Chart] 166 annotations before applied cutoff / 4410 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 1245 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0006319 abnormal epididymal fat pad morphology 1.915E-5 2.384E-2
1.837E-1
 2.384E-2 5 109
2 MP:0005590 increased vasodilation 5.990E-5 2.906E-2
2.239E-1
7.458E-2
 3 25
3 MP:0008544 impaired olfaction 7.586E-5 2.906E-2
2.239E-1
9.444E-2
 3 27
4 MP:0011581 increased triglyceride lipase activity 9.337E-5 2.906E-2
2.239E-1
1.162E-1
 2 5
5 MP:0008713 abnormal cytokine level 2.327E-4 4.855E-2
3.741E-1
2.897E-1
 7 418
6 MP:0011699 abnormal brown adipose tissue thermogenesis 2.599E-4 4.855E-2
3.741E-1
3.236E-1
 2 8
7 MP:0008835 abnormal intercellular signaling peptide or protein level 2.730E-4 4.855E-2
3.741E-1
3.399E-1
 7 429
Show 2 more annotations

6: Domain [Display Chart] 248 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR013642 CLCA InterPro 1.137E-5 9.400E-4 5.727E-3 2.820E-3 2 3
2 PF08434 CLCA Pfam 1.137E-5 9.400E-4 5.727E-3 2.820E-3 2 3
3 IPR004727 CLCA chordata InterPro 1.137E-5 9.400E-4 5.727E-3 2.820E-3 2 3
4 IPR003081 GST mu InterPro 3.781E-5 2.344E-3 1.428E-2 9.377E-3 2 5
5 3.40.50.410 - Gene3D 4.173E-4 1.399E-2
8.526E-2
1.035E-1
 3 74
6 PS50234 VWFA PROSITE 5.640E-4 1.399E-2
8.526E-2
1.399E-1
 3 82
7 SM00327 VWA SMART 6.052E-4 1.399E-2
8.526E-2
1.501E-1
 3 84
8 PF02798 GST N Pfam 8.551E-4 1.399E-2
8.526E-2
2.121E-1
 2 22
9 PS50404 GST NTER PROSITE 8.551E-4 1.399E-2
8.526E-2
2.121E-1
 2 22
10 IPR002035 VWF A InterPro 9.761E-4 1.399E-2
8.526E-2
2.421E-1
 3 99
11 IPR004046 GST C InterPro 1.197E-3 1.399E-2
8.526E-2
2.969E-1
 2 26
12 PF00043 GST C Pfam 1.197E-3 1.399E-2
8.526E-2
2.969E-1
 2 26
13 IPR004045 Glutathione S-Trfase N InterPro 1.291E-3 1.399E-2
8.526E-2
3.202E-1
 2 27
14 PS00303 S100 CABP PROSITE 1.291E-3 1.399E-2
8.526E-2
3.202E-1
 2 27
15 PF01023 S 100 Pfam 1.291E-3 1.399E-2
8.526E-2
3.202E-1
 2 27
16 IPR001751 S100/CaBP-9k CS InterPro 1.389E-3 1.399E-2
8.526E-2
3.444E-1
 2 28
17 IPR013787 S100 Ca-bd sub InterPro 1.389E-3 1.399E-2
8.526E-2
3.444E-1
 2 28
18 SM01394 S 100 SMART 1.389E-3 1.399E-2
8.526E-2
3.444E-1
 2 28
19 3.40.30.10 - Gene3D 1.781E-3 1.399E-2
8.526E-2
4.417E-1
 3 122
20 IPR027067 Integrin beta-5 InterPro 1.975E-3 1.399E-2
8.526E-2
4.898E-1
 1 1
21 IPR000265 Prostglndn EP3 rcpt InterPro 1.975E-3 1.399E-2
8.526E-2
4.898E-1
 1 1
22 IPR028482 S100A11 InterPro 1.975E-3 1.399E-2
8.526E-2
4.898E-1
 1 1
23 IPR028481 S100-B InterPro 1.975E-3 1.399E-2
8.526E-2
4.898E-1
 1 1
24 IPR015644 Peptidase C1A cathepsin-K InterPro 1.975E-3 1.399E-2
8.526E-2
4.898E-1
 1 1
25 IPR000703 Proenkphlin A InterPro 1.975E-3 1.399E-2
8.526E-2
4.898E-1
 1 1
26 PF15103 G0-G1 switch 2 Pfam 1.975E-3 1.399E-2
8.526E-2
4.898E-1
 1 1
27 IPR009345 BAMBI InterPro 1.975E-3 1.399E-2
8.526E-2
4.898E-1
 1 1
28 IPR008122 TF AP2 beta InterPro 1.975E-3 1.399E-2
8.526E-2
4.898E-1
 1 1
29 IPR001481 EP3 rcpt 2 InterPro 1.975E-3 1.399E-2
8.526E-2
4.898E-1
 1 1
30 IPR008051 Na channel a1su InterPro 1.975E-3 1.399E-2
8.526E-2
4.898E-1
 1 1
31 IPR016821 G0S2 InterPro 1.975E-3 1.399E-2
8.526E-2
4.898E-1
 1 1
32 IPR028895 CCNG2 InterPro 1.975E-3 1.399E-2
8.526E-2
4.898E-1
 1 1
33 PF06211 BAMBI Pfam 1.975E-3 1.399E-2
8.526E-2
4.898E-1
 1 1
34 IPR003548 Claudin1 InterPro 1.975E-3 1.399E-2
8.526E-2
4.898E-1
 1 1
35 IPR029528 CETN2 InterPro 1.975E-3 1.399E-2
8.526E-2
4.898E-1
 1 1
36 PS50405 GST CTER PROSITE 2.046E-3 1.409E-2
8.587E-2
5.074E-1
 2 34
37 IPR012336 Thioredoxin-like fold InterPro 2.230E-3 1.494E-2
9.105E-2
5.530E-1
 3 132
38 IPR011992 EF-hand-dom pair InterPro 2.392E-3 1.561E-2
9.513E-2
5.933E-1
 4 287
39 IPR010987 Glutathione-S-Trfase C-like InterPro 2.686E-3 1.665E-2
1.014E-1
6.660E-1
 2 39
40 1.20.1050.10 - Gene3D 2.686E-3 1.665E-2
1.014E-1
6.660E-1
 2 39
41 PF00036 EF-hand 1 Pfam 3.324E-3 1.997E-2
1.217E-1
8.243E-1
 3 152
42 SM00054 EFh SMART 3.706E-3 1.997E-2
1.217E-1
9.190E-1
 3 158
43 IPR026779 Camk2n InterPro 3.946E-3 1.997E-2
1.217E-1
9.786E-1
 1 2
44 PF15170 CaM-KIIN Pfam 3.946E-3 1.997E-2
1.217E-1
9.786E-1
 1 2
45 PF07809 RTP801 C Pfam 3.946E-3 1.997E-2
1.217E-1
9.786E-1
 1 2
46 IPR004123 Dim1 InterPro 3.946E-3 1.997E-2
1.217E-1
9.786E-1
 1 2
47 SM01410 DIM1 SMART 3.946E-3 1.997E-2
1.217E-1
9.786E-1
 1 2
48 PF02966 DIM1 Pfam 3.946E-3 1.997E-2
1.217E-1
9.786E-1
 1 2
49 IPR012918 RTP801-like InterPro 3.946E-3 1.997E-2
1.217E-1
9.786E-1
 1 2
50 IPR018247 EF Hand 1 Ca BS InterPro 4.930E-3 2.445E-2
1.490E-1
1.000E0
 3 175
Show 45 more annotations

7: Pathway [Display Chart] 287 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 198810 TGF Beta Signaling Pathway BioSystems: WikiPathways 5.413E-4 2.439E-2
1.521E-1
1.554E-1
 3 55
2 906020 SMAD2/3 Phosphorylation Motif Mutants in Cancer BioSystems: REACTOME 1.190E-3 2.439E-2
1.521E-1
3.414E-1
 3 72
3 906026 TGFBR1 LBD Mutants in Cancer BioSystems: REACTOME 1.190E-3 2.439E-2
1.521E-1
3.414E-1
 3 72
4 906017 Loss of Function of SMAD4 in Cancer BioSystems: REACTOME 1.190E-3 2.439E-2
1.521E-1
3.414E-1
 3 72
5 906025 Loss of Function of TGFBR1 in Cancer BioSystems: REACTOME 1.190E-3 2.439E-2
1.521E-1
3.414E-1
 3 72
6 906018 SMAD4 MH2 Domain Mutants in Cancer BioSystems: REACTOME 1.190E-3 2.439E-2
1.521E-1
3.414E-1
 3 72
7 906022 Loss of Function of TGFBR2 in Cancer BioSystems: REACTOME 1.190E-3 2.439E-2
1.521E-1
3.414E-1
 3 72
8 906021 SMAD2/3 MH2 Domain Mutants in Cancer BioSystems: REACTOME 1.190E-3 2.439E-2
1.521E-1
3.414E-1
 3 72
9 906016 Signaling by TGF-beta Receptor Complex in Cancer BioSystems: REACTOME 1.190E-3 2.439E-2
1.521E-1
3.414E-1
 3 72
10 906027 TGFBR1 KD Mutants in Cancer BioSystems: REACTOME 1.190E-3 2.439E-2
1.521E-1
3.414E-1
 3 72
11 906019 Loss of Function of SMAD2/3 in Cancer BioSystems: REACTOME 1.190E-3 2.439E-2
1.521E-1
3.414E-1
 3 72
12 106504 Signaling by TGF-beta Receptor Complex BioSystems: REACTOME 1.190E-3 2.439E-2
1.521E-1
3.414E-1
 3 72
13 906024 TGFBR2 Kinase Domain Mutants in Cancer BioSystems: REACTOME 1.190E-3 2.439E-2
1.521E-1
3.414E-1
 3 72
14 906023 TGFBR2 MSI Frameshift Mutants in Cancer BioSystems: REACTOME 1.190E-3 2.439E-2
1.521E-1
3.414E-1
 3 72
15 142435 glutathione-mediated detoxification I BioSystems: BIOCYC 1.380E-3 2.641E-2
1.647E-1
3.961E-1
 2 19
16 137963 Regulation of nuclear SMAD2/3 signaling BioSystems: Pathway Interaction Database 1.500E-3 2.690E-2
1.678E-1
4.304E-1
 3 78
17 MAP00480 Glutathione metabolism MAP00480 Glutathione metabolism GenMAPP 1.854E-3 3.130E-2
1.953E-1
5.321E-1
 2 22
18 PW:0000356 oxygen homeostasis Pathway Ontology 2.931E-3 4.674E-2
2.916E-1
8.413E-1
 1 1
Show 13 more annotations

8: Pubmed [Display Chart] 16127 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18423940 A GSTM3 polymorphism associated with an etiopathogenetic mechanism in Alzheimer disease. Pubmed 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
2 17904251:gr Gene variations in GSTM3 are a risk factor for Alzheimer's disease. GeneRIF 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
3 22322856 The release of S-100B and NSE in severe traumatic head injury is associated with APOE ¿4. Pubmed 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
4 18423940:gr A GSTM3 polymorphism associated with an etiopathogenetic mechanism in Alzheimer disease. GeneRIF 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
5 17904251 Gene variations in GSTM3 are a risk factor for Alzheimer's disease. Pubmed 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
6 16914534:gr IL-1 and IL-6 induce hepatocyte plasminogen activator inhibitor-1 expression through independent signaling pathways converging on C/EBPdelta. GeneRIF 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
7 23112050 Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation. Pubmed 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
8 16914534 IL-1 and IL-6 induce hepatocyte plasminogen activator inhibitor-1 expression through independent signaling pathways converging on C/EBPdelta. Pubmed 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
9 18022660:gr Risk of carotid atherosclerosis associated with genetic polymorphisms of apolipoprotein E and inflammatory genes among arsenic exposed residents in Taiwan. GeneRIF 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
10 16896546 Genes and longevity: a genetic-demographic approach reveals sex- and age-specific gene effects not shown by the case-control approach (APOE and HSP70.1 loci). Pubmed 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
11 18022660 Risk of carotid atherosclerosis associated with genetic polymorphisms of apolipoprotein E and inflammatory genes among arsenic exposed residents in Taiwan. Pubmed 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
12 16896546:gr Genes and longevity: a genetic-demographic approach reveals sex- and age-specific gene effects not shown by the case-control approach (APOE and HSP70.1 loci). GeneRIF 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
13 18262228:gr Plasma PAI-1 levels are independently related to fatty liver and hypertriglyceridemia in familial combined hyperlipidemia, involvement of apolipoprotein E. GeneRIF 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
14 19494437:gr MCP-1 A-2518G polymorphism: effect on susceptibility for frontotemporal lobar degeneration and on cerebrospinal fluid MCP-1 levels. GeneRIF 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
15 18262228 Plasma PAI-1 levels are independently related to fatty liver and hypertriglyceridemia in familial combined hyperlipidemia, involvement of apolipoprotein E. Pubmed 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
16 19368854 No association between the promoter polymorphisms of PAI-1 gene and sporadic Alzheimer's disease in Chinese Han population. Pubmed 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
17 19368854:gr No association between the promoter polymorphisms of PAI-1 gene and sporadic Alzheimer's disease in Chinese Han population. GeneRIF 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
18 22322856:gr The release of S-100B and NSE in severe traumatic head injury is associated with APOE ¿4. GeneRIF 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
19 19494437 MCP-1 A-2518G polymorphism: effect on susceptibility for frontotemporal lobar degeneration and on cerebrospinal fluid MCP-1 levels. Pubmed 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
20 26637413 The lost correlation between heat shock protein 70 (HSPA1A) and plasminogen activator inhibitor-1 in patients with type 2 diabetes and albuminuria. Pubmed 4.954E-7 3.995E-4 4.101E-3 7.989E-3 2 2
21 23728617 Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival. Pubmed 6.699E-7 5.144E-4 5.281E-3 1.080E-2 3 24
22 20382850:gr A causal relationship between shear stress and atherosclerotic lesions in apolipoprotein E knockout mice assessed by ultrasound biomicroscopy. GeneRIF 1.486E-6 6.845E-4 7.027E-3 2.396E-2 2 3
23 10587441 An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases. Pubmed 1.486E-6 6.845E-4 7.027E-3 2.396E-2 2 3
24 20614004 Circulating levels of inflammatory markers in intrauterine growth restriction. Pubmed 1.486E-6 6.845E-4 7.027E-3 2.396E-2 2 3
25 18974580 Polymorphism in methylenetetrahydrofolate reductase, plasminogen activator inhibitor-1, and apolipoprotein E in hemodialysis patients. Pubmed 1.486E-6 6.845E-4 7.027E-3 2.396E-2 2 3
26 18203900:gr Dietary soy protein isolate ameliorates atherosclerotic lesions in apolipoprotein E-deficient mice potentially by inhibiting monocyte chemoattractant protein-1 expression. GeneRIF 1.486E-6 6.845E-4 7.027E-3 2.396E-2 2 3
27 20614004:gr Circulating levels of inflammatory markers in intrauterine growth restriction. GeneRIF 1.486E-6 6.845E-4 7.027E-3 2.396E-2 2 3
28 18974580:gr Polymorphism in methylenetetrahydrofolate reductase, plasminogen activator inhibitor-1, and apolipoprotein E in hemodialysis patients. GeneRIF 1.486E-6 6.845E-4 7.027E-3 2.396E-2 2 3
29 10437792 Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea. Pubmed 1.486E-6 6.845E-4 7.027E-3 2.396E-2 2 3
30 15718495 Interleukin-6 and mevastatin regulate plasminogen activator inhibitor-1 through CCAAT/enhancer-binding protein-delta. Pubmed 1.486E-6 6.845E-4 7.027E-3 2.396E-2 2 3
31 19022887:gr Transcription factor activating protein-2beta: a positive regulator of monocyte chemoattractant protein-1 gene expression. GeneRIF 1.486E-6 6.845E-4 7.027E-3 2.396E-2 2 3
32 22293444:gr Corosolic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice by regulating the nuclear factor-¿B signaling pathway and inhibiting monocyte chemoattractant protein-1 expression. GeneRIF 1.486E-6 6.845E-4 7.027E-3 2.396E-2 2 3
33 15718495:gr Interleukin-6 and mevastatin regulate plasminogen activator inhibitor-1 through CCAAT/enhancer-binding protein-delta. GeneRIF 1.486E-6 6.845E-4 7.027E-3 2.396E-2 2 3
34 22430872 Tissue-based proteomics reveals FXYD3, S100A11 and GSTM3 as novel markers for regional lymph node metastasis in colon cancer. Pubmed 1.486E-6 6.845E-4 7.027E-3 2.396E-2 2 3
35 14512419 The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis. Pubmed 1.486E-6 6.845E-4 7.027E-3 2.396E-2 2 3
36 19019335:gr Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. GeneRIF 1.998E-6 8.639E-4 8.868E-3 3.222E-2 4 125
37 19019335 Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. Pubmed 1.998E-6 8.639E-4 8.868E-3 3.222E-2 4 125
38 19527514:gr Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. GeneRIF 2.196E-6 8.639E-4 8.868E-3 3.542E-2 4 128
39 18818748 Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. Pubmed 2.196E-6 8.639E-4 8.868E-3 3.542E-2 4 128
40 18818748:gr Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. GeneRIF 2.196E-6 8.639E-4 8.868E-3 3.542E-2 4 128
41 19527514 Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. Pubmed 2.196E-6 8.639E-4 8.868E-3 3.542E-2 4 128
42 11071307 Molecular characteristics and functional diversity of CLCA family members. Pubmed 2.970E-6 9.210E-4 9.455E-3 4.789E-2 2 4
43 10913138 S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo. Pubmed 2.970E-6 9.210E-4 9.455E-3 4.789E-2 2 4
44 19151192 Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung function. Pubmed 2.970E-6 9.210E-4 9.455E-3 4.789E-2 2 4
45 22658637:gr TNF-¿ modulates statin effects on secretion and expression of MCP-1, PAI-1 and adiponectin in 3T3-L1 differentiated adipocytes. GeneRIF 2.970E-6 9.210E-4 9.455E-3 4.789E-2 2 4
46 16043164 Contemporaneous carrier-state of two or three "proatherosclerotic" variants of APOE, ICAM1, PPARA and PAI-1 genes differentiate CAD patients from healthy individuals. Pubmed 2.970E-6 9.210E-4 9.455E-3 4.789E-2 2 4
47 12753088 MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. Pubmed 2.970E-6 9.210E-4 9.455E-3 4.789E-2 2 4
48 8373352 Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript. Pubmed 2.970E-6 9.210E-4 9.455E-3 4.789E-2 2 4
49 19151192:gr Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung function. GeneRIF 2.970E-6 9.210E-4 9.455E-3 4.789E-2 2 4
50 16043164:gr Contemporaneous carrier-state of two or three "proatherosclerotic" variants of APOE, ICAM1, PPARA and PAI-1 genes differentiate CAD patients from healthy individuals. GeneRIF 2.970E-6 9.210E-4 9.455E-3 4.789E-2 2 4
Show 45 more annotations

9: Interaction [Display Chart] 1009 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:MMP3 MMP3 interactions 2.455E-5 2.477E-2
1.856E-1
 2.477E-2 3 27
2 int:GSTM2 GSTM2 interactions 6.495E-5 3.277E-2
2.456E-1
6.554E-2
 2 6

10: Cytoband [Display Chart] 34 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1p22.3 1p22.3 2.527E-4 8.592E-3 3.538E-2 8.592E-3 2 22
2 13q31.2-q32.3 13q31.2-q32.3 1.067E-3 1.210E-2 4.982E-2 3.629E-2 1 1
3 10p12.3-p11.2 10p12.3-p11.2 1.067E-3 1.210E-2 4.982E-2 3.629E-2 1 1
4 8p11.2-p11.1 8p11.2-p11.1 2.134E-3 1.739E-2
7.163E-2
7.255E-2
 1 2
5 1p13.3 1p13.3 2.558E-3 1.739E-2
7.163E-2
8.697E-2
 2 70
6 3q28-q29 3q28-q29 4.263E-3 1.896E-2
7.810E-2
1.450E-1
 1 4
7 8q23-q24 8q23-q24 4.263E-3 1.896E-2
7.810E-2
1.450E-1
 1 4
8 1q21 1q21 4.462E-3 1.896E-2
7.810E-2
1.517E-1
 2 93
9 1p31.2 1p31.2 5.326E-3 2.012E-2
8.287E-2
1.811E-1
 1 5
10 17q11.2-q12 17q11.2-q12 7.449E-3 2.533E-2
1.043E-1
2.533E-1
 1 7
11 18p11.3 18p11.3 1.168E-2 3.611E-2
1.487E-1
3.972E-1
 1 11
12 6p12 6p12 1.800E-2 4.936E-2
2.033E-1
6.119E-1
 1 17
13 2q24.3 2q24.3 2.009E-2 4.936E-2
2.033E-1
6.832E-1
 1 19
14 2q14.2 2q14.2 2.114E-2 4.936E-2
2.033E-1
7.188E-1
 1 20
15 4q27 4q27 2.323E-2 4.936E-2
2.033E-1
7.898E-1
 1 22
16 3q21.2 3q21.2 2.323E-2 4.936E-2
2.033E-1
7.898E-1
 1 22
Show 11 more annotations

11: Transcription Factor Binding Site [Display Chart] 191 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 29 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 867 Chloride channel accessory genenames.org 1.368E-5 3.967E-4 1.571E-3 3.967E-4 2 4
2 459 S100 calcium binding proteins|EF-hand domain containing genenames.org 4.710E-4 6.480E-3 2.567E-2 1.366E-2 2 21
3 567 Glutathione S-transferases genenames.org 6.703E-4 6.480E-3 2.567E-2 1.944E-2 2 25
4 863 EF-hand domain containing genenames.org 4.514E-3 3.272E-2
1.296E-1
1.309E-1
 3 219
5 1276 Transcription and export complex 2 genenames.org 7.672E-3 3.993E-2
1.582E-1
2.225E-1
 1 5
6 1165 Basic leucine zipper proteins|CCAAT/enhancer binding proteins genenames.org 9.200E-3 3.993E-2
1.582E-1
2.668E-1
 1 6
7 220 Peptide receptors genenames.org 1.072E-2 3.993E-2
1.582E-1
3.110E-1
 1 7
8 207 Prostaglandin (prostanoid) receptors genenames.org 1.377E-2 3.993E-2
1.582E-1
3.993E-1
 1 9
9 1159 CD molecules|Integrin beta subunits genenames.org 1.377E-2 3.993E-2
1.582E-1
3.993E-1
 1 9
10 1203 Sodium voltage-gated channel alpha subunits genenames.org 1.377E-2 3.993E-2
1.582E-1
3.993E-1
 1 9
11 974 Acyl-CoA dehydrogenase family genenames.org 1.680E-2 4.430E-2
1.755E-1
4.873E-1
 1 11
Show 6 more annotations

13: Coexpression [Display Chart] 3366 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5230 Genes down-regulated in comparison of dendritic cells (DC) exposed to 5 worms/well B. malayi versus DC exposed to M. tuberculosis MSigDB C7: Immunologic Signatures (v5.1) 9.681E-7 1.678E-3 1.459E-2 3.259E-3 6 199
2 M5890 Genes regulated by NF-kB in response to TNF [GeneID=7124]. MSigDB H: Hallmark Gene Sets (v5.1) 9.969E-7 1.678E-3 1.459E-2 3.355E-3 6 200
3 M15193 Genes up-regulated in pancreatic ductal adenocarcinoma (PDAC) identified in a meta analysis across four independent studies. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.006E-6 2.250E-3 1.958E-2 6.751E-3 7 358
4 M15981 Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.696E-6 5.029E-3 4.375E-2 2.254E-2 7 430
5 GSE37605 FOXP3 FUSION GFP VS IRES GFP TREG C57BL6 UP Genes up-regulated in T reg (FOXP3+ [GeneID=50943]) cells from B6 mice: Foxp3-Fusion-GFP versus Foxp3-ires-GFP. MSigDB C7: Immunologic Signatures (v5.1) 1.328E-5 5.029E-3 4.375E-2 4.469E-2 5 182
6 M3804 Genes up-regulated in normal hematopoietic progenitors by RUNX1-RUNX1T1 [GeneID=861;862] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.437E-5 5.029E-3 4.375E-2 4.836E-2 5 185
7 M5622 Cluster G2: genes increasingly up-regulated in NHEK cells (normal keratinocyte) and reaching maximum levels at 12 h and 24 h after UV-B irradiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.754E-5 5.029E-3 4.375E-2
5.905E-2
 3 30
8 M11840 Human orthologs of genes down-regulated in zebra fish after knockdown of BMYB [GeneID=4605] by morpholino. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.042E-5 5.029E-3 4.375E-2
6.873E-2
 5 199
9 GSE22196 HEALTHY VS OBESE MOUSE SKIN GAMMADELTA TCELL DN Genes down-regulated in skin gamma delta T cells: healthy versus obesity. MSigDB C7: Immunologic Signatures (v5.1) 2.092E-5 5.029E-3 4.375E-2
7.041E-2
 5 200
10 GSE19401 NAIVE VS IMMUNIZED MOUSE PLN FOLLICULAR DC UP Genes up-regulated in ex vivo follicular dendritic cells from peripheral lymph nodes: naïve versus immunized mice. MSigDB C7: Immunologic Signatures (v5.1) 2.092E-5 5.029E-3 4.375E-2
7.041E-2
 5 200
11 M5834 Genes down-regulated in comparison of effector CD8 T cells versus exhausted CD8 T cells. MSigDB C7: Immunologic Signatures (v5.1) 2.092E-5 5.029E-3 4.375E-2
7.041E-2
 5 200
12 GSE46143 CTRL VS LMP2A TRANSDUCED CD10 POS GC BCELL DN Genes down-regulated in MME+ [GeneID=4311] germinal center B lymphocytes: control versus over-expressing viral (EBV) gene LMP2A. MSigDB C7: Immunologic Signatures (v5.1) 2.092E-5 5.029E-3 4.375E-2
7.041E-2
 5 200
13 M5176 Genes down-regulated in comparison of dendritic cells (DC) exposed to L. donovani versus macrophages exposed to L. donovani. MSigDB C7: Immunologic Signatures (v5.1) 2.092E-5 5.029E-3 4.375E-2
7.041E-2
 5 200
14 M3987 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 1 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 1 h. MSigDB C7: Immunologic Signatures (v5.1) 2.092E-5 5.029E-3 4.375E-2
7.041E-2
 5 200
15 M19693 Genes up-regulated in NHEK cells (normal keratinocytes) by UV-B irradiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.407E-5 1.213E-2
1.055E-1
1.820E-1
 5 244
16 M19971 Genes up-regulated in peripheral blood mononucleocytes by HGF [GeneID=3082] compared to those regulated by CSF2RB (GM-CSF) and IL4 [GeneID=1437;3565]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.794E-5 1.219E-2
1.060E-1
1.950E-1
 6 408
17 M14555 Down-regulated at any timepoint following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v5.1) 6.369E-5 1.261E-2
1.097E-1
2.144E-1
 4 128
18 M19622 Genes up-regulated in HK-2 cells kidney tubular epithelium) under hypoxia and down-regulated on re-oxygenation. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.869E-5 1.274E-2
1.108E-1
2.312E-1
 3 47
19 M4339 Genes down-regulated in SCLC (small cell lung cancer) cells with acquired resistance to ABT-737 [PubChem=11228183], an inhibitor of the BCL2 [GeneID=596] family proteins. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.319E-5 1.274E-2
1.108E-1
2.463E-1
 3 48
20 M5547 Age up-regulated genes in the human frontal cortex. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.572E-5 1.274E-2
1.108E-1
2.549E-1
 5 262
21 M15491 Genes down-regulated in MDA-MB-231 cells (breast cancer) after knockdown of SATB1 [GeneID=6304] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.010E-5 1.382E-2
1.202E-1
3.033E-1
 6 442
22 M3645 Genes up-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.122E-5 1.382E-2
1.202E-1
3.071E-1
 6 443
23 GSE37605 TREG VS TCONV NOD FOXP3 FUSION GFP UP Genes up-regulated in splenocytes from Foxp3-Fusion-GFP NOD mice: T reg (FOXP3+ [GeneID=50943]) versus T conv (FOXP3- [GeneID=50943]) cells. MSigDB C7: Immunologic Signatures (v5.1) 9.530E-5 1.382E-2
1.202E-1
3.208E-1
 4 142
24 M9806 Down-regulated at 8 h following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v5.1) 9.855E-5 1.382E-2
1.202E-1
3.317E-1
 3 53
25 GSE36891 POLYIC TLR3 VS PAM TLR2 STIM PERITONEAL MACROPHAGE UP Genes up-regulated in peritoneal macrophages: poly(IC) versus Pam3Cys-Ser-(Lys)4 [PubChem=130704]. MSigDB C7: Immunologic Signatures (v5.1) 1.061E-4 1.411E-2
1.227E-1
3.572E-1
 4 146
26 GSE36891 UNSTIM VS POLYIC TLR3 STIM PERITONEAL MACROPHAGE UP Genes up-regulated in peritoneal macrophages: untreated versus poly(IC). MSigDB C7: Immunologic Signatures (v5.1) 1.090E-4 1.411E-2
1.227E-1
3.667E-1
 4 147
27 M1218 Genes up-regulated in hepatocellular carcinoma (HCC) developed by transgenic mice overexpressing a secretable form of EGF [GeneID=1950] in liver. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.225E-4 1.486E-2
1.293E-1
4.124E-1
 3 57
28 M988 Genes up-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.271E-4 1.486E-2
1.293E-1
4.280E-1
 4 153
29 M1914 Genes up-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.280E-4 1.486E-2
1.293E-1
4.310E-1
 5 293
30 M14344 Genes up-regulated in normal fibroblasts in response to IL6 [GeneID=3569]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.358E-4 1.505E-2
1.309E-1
4.571E-1
 3 59
31 M10319 Genes up-regulated in prostate cancer samples from African-American patients compared to those from the European-American patients. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.386E-4 1.505E-2
1.309E-1
4.665E-1
 5 298
32 M15535 Genes up-regulated in UB27 cells (osteosarcoma) at 12 hr after inducing the expression of a mutated form of WT1 [GeneID=7490]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.584E-4 1.653E-2
1.438E-1
5.333E-1
 4 162
33 M1430 Genes defining differentiation potential of the bipotential myeloid cell line FDB. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.700E-4 1.653E-2
1.438E-1
5.722E-1
 4 165
34 M1576 Selected genes down-regulated during differentiation of 3T3-L1 cells (fibroblast) into adipocytes in response to adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.730E-4 1.653E-2
1.438E-1
5.825E-1
 3 64
35 M9775 Genes up-regulated in T helper cells (defines as CD4+) isolated from patients with mucosis fungoides compared to those from normal control donors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.730E-4 1.653E-2
1.438E-1
5.825E-1
 3 64
36 M8582 Genes down-regulated in peripheral blood monocytes by CSF2RB (GM-CSF) and IL4 [GeneID=1437;3565]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.768E-4 1.653E-2
1.438E-1
5.952E-1
 5 314
37 GSE32255 WT UNSTIM VS JMJD2D KNOCKDOWN 4H LPS STIM DC DN Genes down-regulated in dendritic cells: unstimulated wildtype versus KDM4D [GeneID=55693] knockdown (shRNA) stimulated by LPS. MSigDB C7: Immunologic Signatures (v5.1) 1.949E-4 1.753E-2
1.525E-1
6.562E-1
 4 171
38 M2067 Genes up-regulated in MEF cells (embryonic fibroblast) lacking TP53 and BRCA1 [GeneID=7157;672] by expression of BRCA1. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.148E-4 1.753E-2
1.525E-1
7.229E-1
 2 13
39 M2041 Genes down-regulated in 3T3-L1 cells (fibroblast) induced to differentiate to mature adipocytes and then treated with a TZD derivative AD-5075 [PubChem=128440], a PPARG [GeneID=5468] activator. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.148E-4 1.753E-2
1.525E-1
7.229E-1
 2 13
40 M5652 Genes which best discriminated between two groups of breast cancer according to the status of ESR1 and AR [GeneID=2099;367]: basal (ESR1- AR-) and luminal (ESR1+ AR+). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.227E-4 1.753E-2
1.525E-1
7.495E-1
 5 330
41 M2504 Genes whose expression changes in Calu-6 cells (lung cancer) by TNF [GeneID=7124] were not affected by p38 inhibitor LY479754. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.453E-4 1.753E-2
1.525E-1
8.258E-1
 5 337
42 GSE37605 C57BL6 VS NOD FOXP3 FUSION GFP TREG DN Genes down-regulated in Foxp3-Fusion-GFP T reg (FOXP3+ [GeneID=50943]): B6 versus NOD background. MSigDB C7: Immunologic Signatures (v5.1) 2.688E-4 1.753E-2
1.525E-1
9.047E-1
 4 186
43 M1451 Top 100 probe sets contrubuting to the negative side of the 2nd principal component; associated with adipocytic differentiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.349E-4 1.753E-2
1.525E-1
1.000E0
 3 80
44 M4222 Genes down-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 12 h versus the untreated cells at 12 h. MSigDB C7: Immunologic Signatures (v5.1) 3.408E-4 1.753E-2
1.525E-1
1.000E0
 4 198
45 M5184 Genes down-regulated in comparison of dendritic cells (DC) exposed to T. gondii versus macrophages exposed to T. gondii. MSigDB C7: Immunologic Signatures (v5.1) 3.474E-4 1.753E-2
1.525E-1
1.000E0
 4 199
46 GSE36826 WT VS IL1R KO SKIN UP Genes up-regulated in skin: wildtype versus IL1R1 [GeneID=3554] knockout. MSigDB C7: Immunologic Signatures (v5.1) 3.474E-4 1.753E-2
1.525E-1
1.000E0
 4 199
47 M5235 Genes up-regulated in comparison of macrophages exposed to L. donovani versus macrophages exposed to 50 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v5.1) 3.474E-4 1.753E-2
1.525E-1
1.000E0
 4 199
48 M2424 Genes up-regulated in neonatal cardiac myocytes upon knockdown of BCL3 [GeneID=602] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.498E-4 1.753E-2
1.525E-1
1.000E0
 5 364
49 M3502 Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 80 min. MSigDB C7: Immunologic Signatures (v5.1) 3.541E-4 1.753E-2
1.525E-1
1.000E0
 4 200
50 GSE22140 GERMFREE VS SPF MOUSE CD4 TCELL DN Genes down-regulated in healthy CD4 [GeneID=920] T cells: germ free versus specific pathogen free. MSigDB C7: Immunologic Signatures (v5.1) 3.541E-4 1.753E-2
1.525E-1
1.000E0
 4 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 1771 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 2.157E-10 3.821E-7 3.078E-6 3.821E-7 11 467
2 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 3.210E-9 2.842E-6 2.290E-5 5.684E-6 10 455
3 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 5.301E-8 3.129E-5 2.521E-4 9.388E-5 9 453
4 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 6.148E-7 2.722E-4 2.193E-3 1.089E-3 8 438
5 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 9.051E-6 3.206E-3 2.583E-2 1.603E-2 7 445
6 GSM777055 100 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 1.404E-5 3.719E-3 2.996E-2 2.486E-2 4 86
7 GSM777050 100 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 1.470E-5 3.719E-3 2.996E-2 2.603E-2 4 87
8 26Dn SubClass 26Dn 2 Top 500 All 26Dn SubClass 26Dn 2 Top 500 All Brain Map - Allen iN 1.874E-5 4.149E-3 3.343E-2 3.319E-2 7 498
9 gudmap developingLowerUrinaryTract P1 bladder J 200 k3 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.466E-5 6.454E-3
5.200E-2
6.139E-2
 3 37
10 gudmap developingKidney e15.5 Peripheral blastema 1000 k2 DevelopingKidney e15.5 Peripheral blastema emap-27731 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.708E-5 6.454E-3
5.200E-2
8.338E-2
 5 234
11 gudmap developingGonad e18.5 epididymis 1000 k5 DevelopingGonad e18.5 epididymis emap-13166 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.708E-5 6.454E-3
5.200E-2
8.338E-2
 5 234
12 gudmap developingLowerUrinaryTract P1 ureter 500 DevelopingLowerUrinaryTract P1 ureter emap-30363 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.971E-5 6.454E-3
5.200E-2
8.804E-2
 6 392
13 gudmap developingLowerUrinaryTract P1 ureter 1000 k1 DevelopingLowerUrinaryTract P1 ureter emap-30363 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.382E-5 6.454E-3
5.200E-2
9.531E-2
 4 121
14 Facebase ST1 e11.5 Emin MedNasl SingCel 500 e11.5 Emin MedNasl SingCel top-relative-expression-ranked 500 FaceBase_ST1 5.409E-5 6.454E-3
5.200E-2
9.579E-2
 6 398
15 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 500 k1 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.467E-5 6.454E-3
5.200E-2
9.681E-2
 3 43
16 GSM605823 500 Myeloid Cells, DC.103-11b+.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3 Immgen.org, GSE15907 6.291E-5 6.963E-3
5.610E-2
1.114E-1
 6 409
17 GSM854271 500 Myeloid Cells, DC.103-11b+24-.Lu, MHCII+ CD11c+ CD103- CD11b+ CD24-, Lung, avg-2 Immgen.org, GSE15907 6.728E-5 7.009E-3
5.647E-2
1.191E-1
 6 414
18 gudmap kidney e10.5 UretericTrunk HoxB7 k4 1000 kidney e10.5 UretericTrunk HoxB7 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.209E-4 1.190E-2
9.586E-2
2.142E-1
 3 56
19 PCBC ratio ECTO blastocyst vs ECTO amniotic fluid MSC cfr-2X-p05 ECTO blastocyst vs ECTO amniotic fluid MSC-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.295E-4 1.207E-2
9.728E-2
2.294E-1
 5 290
20 gudmap developingGonad P2 epididymis 200 k1 DevelopingGonad P2 epididymis emap-30199 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.561E-4 1.325E-2
1.067E-1
2.764E-1
 3 61
21 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 1.750E-4 1.325E-2
1.067E-1
3.100E-1
 6 493
22 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 1.809E-4 1.325E-2
1.067E-1
3.203E-1
 6 496
23 26Dp SubClass 26Dp 2 Top 500 All 26Dp SubClass 26Dp 2 Top 500 All Brain Map - Allen iN 1.809E-4 1.325E-2
1.067E-1
3.203E-1
 6 496
24 gudmap kidney e15.5 Podocyte MafB k2 100 kidney e15.5 Podocyte MafB k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.870E-4 1.325E-2
1.067E-1
3.312E-1
 2 12
25 gudmap dev gonad e11.5 F GonMes Sma k1 100 dev gonad e11.5 F GonMes Sma k-means-cluster#1 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 1.870E-4 1.325E-2
1.067E-1
3.312E-1
 2 12
26 26Dn SubClass 26Dn 2 Top 500 Cluster 3 26Dn SubClass 26Dn 2 Top 500 Cluster 3 Brain Map - Allen iN 2.251E-4 1.533E-2
1.235E-1
3.986E-1
 3 69
27 gudmap developingLowerUrinaryTract P1 bladder J 500 k1 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.995E-4 1.965E-2
1.583E-1
5.305E-1
 3 76
28 PCBC ratio ECTO blastocyst vs ECTO cord blood cfr-2X-p05 ECTO blastocyst vs ECTO cord blood-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 3.188E-4 1.993E-2
1.606E-1
5.645E-1
 4 192
29 gudmap developingLowerUrinaryTract e14.5 bladder 200 k2 DevelopingLowerUrinaryTract e14.5 bladder emap-30872 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.386E-4 1.993E-2
1.606E-1
5.996E-1
 2 16
30 GSM605865 100 Myeloid Cells, MF.Thio5.II-480int.PC, CD115+ MHCII- F480int SiglecF- CD11c+, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 3.614E-4 1.993E-2
1.606E-1
6.400E-1
 3 81
31 gudmap kidney e13.5 Podocyte MafB k4 1000 kidney e13.5 Podocyte MafB k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.747E-4 1.993E-2
1.606E-1
6.636E-1
 3 82
32 gudmap dev gonad e11.5 M GonadVasMes Flk k2 100 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 3.833E-4 1.993E-2
1.606E-1
6.788E-1
 2 17
33 gudmap kidney P4 CapMesRenVes Crym k4 200 kidney P4 CapMesRenVes Crym k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.833E-4 1.993E-2
1.606E-1
6.788E-1
 2 17
34 gudmap developingLowerUrinaryTract e14.5 bladder 100 DevelopingLowerUrinaryTract e14.5 bladder emap-30872 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 3.883E-4 1.993E-2
1.606E-1
6.876E-1
 3 83
35 gudmap kidney adult RenalCapsule k2 1000 kidney adult RenalCapsule k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.047E-4 1.993E-2
1.606E-1
7.168E-1
 5 371
36 gudmap developingKidney e15.5 Peripheral blastema 500 k2 DevelopingKidney e15.5 Peripheral blastema emap-27731 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.162E-4 1.993E-2
1.606E-1
7.370E-1
 4 206
37 Facebase ST1 e11.5 Emin MedNasl SingCel 100 e11.5 Emin MedNasl SingCel top-relative-expression-ranked 100 FaceBase_ST1 4.164E-4 1.993E-2
1.606E-1
7.374E-1
 3 85
38 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB k4 100 dev gonad e13.5 F VascAssocMesenchStromOvary MafB k-means-cluster#4 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 4.307E-4 2.007E-2
1.617E-1
7.628E-1
 2 18
39 microglia Top 500 Cluster 4 microglia Top 500 Cluster 4 Brain Map - Barres 4.458E-4 2.024E-2
1.631E-1
7.895E-1
 3 87
40 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 500 k2 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.765E-4 2.028E-2
1.634E-1
8.439E-1
 3 89
41 gudmap kidney adult RenalCapsule 100 kidney adult RenalCapsule top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 4.765E-4 2.028E-2
1.634E-1
8.439E-1
 3 89
42 gudmap dev gonad e12.5 F VasAssocMesStromOvary Sma k2 200 dev gonad e12.5 F VasAssocMesStromOvary Sma k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 4.809E-4 2.028E-2
1.634E-1
8.517E-1
 2 19
43 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 1000 k5 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.251E-4 2.101E-2
1.692E-1
9.299E-1
 3 92
44 gudmap kidney e15.5 Podocyte MafB k3 200 kidney e15.5 Podocyte MafB k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.337E-4 2.101E-2
1.692E-1
9.453E-1
 2 20
45 gudmap dev gonad e11.5 F GonMes Sma k1 200 dev gonad e11.5 F GonMes Sma k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 5.337E-4 2.101E-2
1.692E-1
9.453E-1
 2 20
46 GSM854320 500 Myeloid Cells, MF.Lv, CD45+ F4/80+ CD11b+, Liver, avg-2 Immgen.org, GSE15907 5.831E-4 2.221E-2
1.789E-1
1.000E0
 5 402
47 DevelopingLowerUrinaryTract e14.5 bladder emap-6668 k1 200 DevelopingLowerUrinaryTract e14.5 bladder emap-6668 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.893E-4 2.221E-2
1.789E-1
1.000E0
 2 21
48 gudmap developingGonad P2 epididymis 1000 k2 DevelopingGonad P2 epididymis emap-30199 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.300E-4 2.249E-2
1.812E-1
1.000E0
 4 230
49 GSM538239 500 Myeloid Cells, DC.103-11b+.Lv, CD45+ CD11c+ MHC-II + CD11b high CD103-, Liver, avg-3 Immgen.org, GSE15907 6.445E-4 2.249E-2
1.812E-1
1.000E0
 5 411
50 GSM854302 500 Stromal Cells, Ep.MEChi.Th, CD45-EpCAm+Ly51-MHCIIhi, Thymus, avg-1 Immgen.org, GSE15907 6.445E-4 2.249E-2
1.812E-1
1.000E0
 5 411
Show 45 more annotations

15: Computational [Display Chart] 204 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 1.022E-7 2.085E-5 1.230E-4 2.085E-5 10 351
2 module 19 Genes in module 19 MSigDb: C4 - CM: Cancer Modules 4.841E-6 4.938E-4 2.912E-3 9.876E-4 8 307
3 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 1.591E-5 1.082E-3 6.381E-3 3.246E-3 8 361
4 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 2.221E-5 1.133E-3 6.681E-3 4.531E-3 8 378
5 module 60 Genes in module 60 MSigDb: C4 - CM: Cancer Modules 3.985E-5 1.626E-3 9.589E-3 8.129E-3 8 410
6 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 3.449E-4 1.173E-2
6.916E-2
7.036E-2
 7 419
7 module 17 Genes in module 17 MSigDb: C4 - CM: Cancer Modules 8.926E-4 2.601E-2
1.534E-1
1.821E-1
 6 353
8 module 53 Genes in module 53 MSigDb: C4 - CM: Cancer Modules 1.516E-3 3.620E-2
2.135E-1
3.092E-1
 6 391
9 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 1.597E-3 3.620E-2
2.135E-1
3.258E-1
 6 395
10 module 6 Genes in module 6 MSigDb: C4 - CM: Cancer Modules 1.861E-3 3.796E-2
2.239E-1
3.796E-1
 6 407
11 module 310 Genes in module 310 MSigDb: C4 - CM: Cancer Modules 2.126E-3 3.943E-2
2.326E-1
4.338E-1
 2 21
12 module 18 Genes in module 18 MSigDb: C4 - CM: Cancer Modules 2.636E-3 4.111E-2
2.425E-1
5.376E-1
 6 436
13 module 24 Genes in module 24 MSigDb: C4 - CM: Cancer Modules 2.920E-3 4.111E-2
2.425E-1
5.956E-1
 6 445
14 module 38 Genes in module 38 MSigDb: C4 - CM: Cancer Modules 3.262E-3 4.111E-2
2.425E-1
6.654E-1
 6 455
15 module 44 Genes in module 44 MSigDb: C4 - CM: Cancer Modules 3.587E-3 4.111E-2
2.425E-1
7.316E-1
 5 319
16 module 212 Genes in module 212 MSigDb: C4 - CM: Cancer Modules 3.635E-3 4.111E-2
2.425E-1
7.415E-1
 5 320
17 module 128 Genes in module 128 MSigDb: C4 - CM: Cancer Modules 3.998E-3 4.111E-2
2.425E-1
8.157E-1
 3 98
18 module 220 Genes in module 220 MSigDb: C4 - CM: Cancer Modules 4.040E-3 4.111E-2
2.425E-1
8.242E-1
 5 328
19 module 497 Genes in module 497 MSigDb: C4 - CM: Cancer Modules 4.044E-3 4.111E-2
2.425E-1
8.250E-1
 2 29
20 module 79 Genes in module 79 MSigDb: C4 - CM: Cancer Modules 4.232E-3 4.111E-2
2.425E-1
8.633E-1
 3 100
21 module 170 Genes in module 170 MSigDb: C4 - CM: Cancer Modules 4.232E-3 4.111E-2
2.425E-1
8.633E-1
 3 100
22 module 192 Genes in module 192 MSigDb: C4 - CM: Cancer Modules 4.598E-3 4.263E-2
2.514E-1
9.379E-1
 3 103
23 GNF2 MMP1 Neighborhood of MMP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.910E-3 4.342E-2
2.561E-1
1.000E0
 2 32
24 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 5.246E-3 4.342E-2
2.561E-1
1.000E0
 4 216
25 module 15 Genes in module 15 MSigDb: C4 - CM: Cancer Modules 5.321E-3 4.342E-2
2.561E-1
1.000E0
 5 350
26 GNF2 PTX3 Neighborhood of PTX3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.186E-3 4.853E-2
2.862E-1
1.000E0
 2 36
Show 21 more annotations

16: MicroRNA [Display Chart] 498 annotations before applied cutoff / 19844 genes in category

No results to display

17: Drug [Display Chart] 10641 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 D003035 Cobalt CTD 3.284E-7 3.494E-3 3.442E-2 3.494E-3 7 276
2 C010313 pseudocumene CTD 9.112E-7 3.782E-3 3.725E-2 9.696E-3 6 199
3 C501413 tesaglitazar CTD 1.306E-6 3.782E-3 3.725E-2 1.390E-2 8 495
4 D015025 Zearalenone CTD 1.493E-6 3.782E-3 3.725E-2 1.588E-2 7 346
5 D004137 Dinitrochlorobenzene CTD 2.015E-6 3.782E-3 3.725E-2 2.144E-2 7 362
6 C039671 ciglitazone CTD 2.836E-6 3.782E-3 3.725E-2 3.018E-2 6 242
7 C425931 GW 501516 CTD 3.461E-6 3.782E-3 3.725E-2 3.683E-2 4 62
8 D016685 Mitomycin CTD 4.434E-6 3.782E-3 3.725E-2 4.718E-2 7 408
9 D002185 Cannabidiol CTD 5.432E-6 3.782E-3 3.725E-2
5.780E-2
 5 153
10 C002802 tungsten carbide CTD 5.787E-6 3.782E-3 3.725E-2
6.158E-2
 5 155
11 C500085 muraglitazar CTD 7.267E-6 3.782E-3 3.725E-2
7.733E-2
 7 440
12 CID000003816 NSC759587 Stitch 7.708E-6 3.782E-3 3.725E-2
8.202E-2
 7 444
13 CID000000838 L-adrenaline Stitch 7.937E-6 3.782E-3 3.725E-2
8.446E-2
 7 446
14 3518 UP Pyrvinium pamoate [3546-41-6]; Up 200; 3.4uM; MCF7; HT HG-U133A Broad Institute CMAP 8.081E-6 3.782E-3 3.725E-2
8.599E-2
 5 166
15 MESH:D050197/D000171-M Atherosclerosis affected by Acrolein CTD Marker 8.175E-6 3.782E-3 3.725E-2
8.699E-2
 2 3
16 C006852 butralin CTD 8.175E-6 3.782E-3 3.725E-2
8.699E-2
 2 3
17 C451427 zoxamide CTD 8.175E-6 3.782E-3 3.725E-2
8.699E-2
 2 3
18 C550006 fluoxastrobin CTD 8.175E-6 3.782E-3 3.725E-2
8.699E-2
 2 3
19 CID000107257 p-bromomethamphetamine Stitch 8.175E-6 3.782E-3 3.725E-2
8.699E-2
 2 3
20 C467051 trifloxystrobin CTD 8.175E-6 3.782E-3 3.725E-2
8.699E-2
 2 3
21 C508135 spirodiclofen CTD 8.175E-6 3.782E-3 3.725E-2
8.699E-2
 2 3
22 C031394 difenzoquat CTD 8.175E-6 3.782E-3 3.725E-2
8.699E-2
 2 3
23 C401104 indoxacarb CTD 8.175E-6 3.782E-3 3.725E-2
8.699E-2
 2 3
24 4018 UP Niclosamide [50-65-7]; Up 200; 12.2uM; PC3; HT HG-U133A Broad Institute CMAP 8.566E-6 3.798E-3 3.741E-2
9.115E-2
 5 168
25 D002791 Cholesterol, Dietary CTD 9.603E-6 4.087E-3 4.026E-2
1.022E-1
 4 80
26 D002725 Chloroform CTD 1.340E-5 4.456E-3 4.389E-2
1.426E-1
 4 87
27 D007608 Kainic Acid CTD 1.402E-5 4.456E-3 4.389E-2
1.492E-1
 5 186
28 CID004634040 AC1NDZBW Stitch 1.439E-5 4.456E-3 4.389E-2
1.531E-1
 5 187
29 D034341 Aristolochic Acids CTD 1.467E-5 4.456E-3 4.389E-2
1.561E-1
 4 89
30 D005473 Fluoxetine CTD 1.503E-5 4.456E-3 4.389E-2
1.600E-1
 6 324
31 1550 UP Labetalol hydrochloride [32780-64-6]; Up 200; 11uM; HL60; HG-U133A Broad Institute CMAP 1.554E-5 4.456E-3 4.389E-2
1.654E-1
 5 190
32 C072763 azamethiphos CTD 1.633E-5 4.456E-3 4.389E-2
1.738E-1
 2 4
33 C508136 etoxazole CTD 1.633E-5 4.456E-3 4.389E-2
1.738E-1
 2 4
34 C106572 3-iodo-2-propynylbutylcarbamate CTD 1.633E-5 4.456E-3 4.389E-2
1.738E-1
 2 4
35 C028912 methylene bis(thiocyanate) CTD 1.633E-5 4.456E-3 4.389E-2
1.738E-1
 2 4
36 C487162 butafenacil CTD 1.633E-5 4.456E-3 4.389E-2
1.738E-1
 2 4
37 C465366 cyazofamid CTD 1.633E-5 4.456E-3 4.389E-2
1.738E-1
 2 4
38 C012864 dazomet CTD 1.633E-5 4.456E-3 4.389E-2
1.738E-1
 2 4
39 MESH:D050197/D007501-M Atherosclerosis affected by Iron CTD Marker 1.633E-5 4.456E-3 4.389E-2
1.738E-1
 2 4
40 4537 UP Orphenadrine hydrochloride [341-69-5]; Up 200; 13uM; PC3; HT HG-U133A Broad Institute CMAP 1.718E-5 4.571E-3 4.502E-2
1.828E-1
 5 194
41 3517 UP Torsemide [56211-40-6]; Up 200; 11.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.805E-5 4.685E-3 4.615E-2
1.921E-1
 5 196
42 CID000007934 m-toluidine Stitch 2.495E-5 5.905E-3
5.816E-2
2.655E-1
 3 34
43 D005632 Fructose CTD 2.515E-5 5.905E-3
5.816E-2
2.676E-1
 5 210
44 C446685 systhane CTD 2.713E-5 5.905E-3
5.816E-2
2.887E-1
 4 104
45 C055370 lactofen CTD 2.719E-5 5.905E-3
5.816E-2
2.894E-1
 2 5
46 C002771 Omite CTD 2.719E-5 5.905E-3
5.816E-2
2.894E-1
 2 5
47 C501339 2-(2,6-diisopropylphenyl)-5-hydroxy-1H-isoindole-1,3-dione CTD 2.719E-5 5.905E-3
5.816E-2
2.894E-1
 2 5
48 MESH:D050197/D010672-T Atherosclerosis affected by Phenytoin CTD Therapeutic 2.719E-5 5.905E-3
5.816E-2
2.894E-1
 2 5
49 C076154 dimethomorph CTD 2.719E-5 5.905E-3
5.816E-2
2.894E-1
 2 5
50 C032910 triadimefon CTD 3.319E-5 7.021E-3
6.915E-2
3.531E-1
 6 373
Show 45 more annotations

18: Disease [Display Chart] 1381 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0036646 Age-related cataract DisGeNET Curated 2.294E-6 1.980E-3 1.546E-2 3.169E-3 4 45
2 umls:C2936349 Plaque, Amyloid DisGeNET Curated 4.111E-6 1.980E-3 1.546E-2 5.678E-3 6 207
3 umls:C0600452 Hepatopulmonary Syndrome DisGeNET BeFree 4.302E-6 1.980E-3 1.546E-2 5.941E-3 2 2
4 umls:C1306889 Peripheral arterial occlusive disease DisGeNET BeFree 8.073E-6 2.787E-3 2.176E-2 1.115E-2 3 19
5 umls:C0025286 Meningioma DisGeNET Curated 1.236E-5 3.052E-3 2.383E-2 1.707E-2 7 383
6 umls:C0333463 Senile Plaques DisGeNET Curated 1.326E-5 3.052E-3 2.383E-2 1.831E-2 6 254
7 umls:C0001849 AIDS Dementia Complex DisGeNET BeFree 4.056E-5 5.714E-3 4.461E-2
5.601E-2
 3 32
8 umls:C1527311 Brain Edema DisGeNET Curated 4.056E-5 5.714E-3 4.461E-2
5.601E-2
 3 32
9 umls:C0037926 Compression of spinal cord DisGeNET Curated 4.285E-5 5.714E-3 4.461E-2
5.918E-2
 2 5
10 umls:C0036349 Paranoid Schizophrenia DisGeNET Curated 4.455E-5 5.714E-3 4.461E-2
6.152E-2
 3 33
11 umls:C0001339 Acute pancreatitis DisGeNET BeFree 4.551E-5 5.714E-3 4.461E-2
6.285E-2
 4 95
12 umls:C0340643 Dissection of aorta DisGeNET BeFree 5.328E-5 6.132E-3 4.788E-2
7.359E-2
 3 35
13 umls:C0520679 Sleep Apnea, Obstructive DisGeNET Curated 6.246E-5 6.635E-3
5.181E-2
8.626E-2
 4 103
14 umls:C0029877 Ear Inflammation DisGeNET BeFree 8.975E-5 8.263E-3
6.452E-2
1.239E-1
 2 7
15 umls:C0079102 Cerebral Thrombosis DisGeNET BeFree 8.975E-5 8.263E-3
6.452E-2
1.239E-1
 2 7
16 umls:C0017612 Glaucoma, Open-Angle DisGeNET Curated 9.932E-5 8.573E-3
6.694E-2
1.372E-1
 3 43
17 umls:C0347950 Asthma attack DisGeNET BeFree 1.195E-4 9.333E-3
7.287E-2
1.650E-1
 2 8
18 umls:C0007282 Carotid Stenosis DisGeNET Curated 1.216E-4 9.333E-3
7.287E-2
1.680E-1
 3 46
19 umls:C0751956 Acute Cerebrovascular Accidents DisGeNET BeFree 1.470E-4 1.068E-2
8.343E-2
2.030E-1
 3 49
20 umls:C0085584 Encephalopathies DisGeNET BeFree 1.683E-4 1.150E-2
8.981E-2
2.324E-1
 4 133
21 umls:C0041696 Unipolar Depression DisGeNET BeFree 1.777E-4 1.150E-2
8.981E-2
2.454E-1
 6 405
22 umls:C0162871 Aortic Aneurysm, Abdominal DisGeNET Curated 1.886E-4 1.150E-2
8.981E-2
2.605E-1
 4 137
23 umls:C0009766 Allergic Conjunctivitis DisGeNET BeFree 1.916E-4 1.150E-2
8.981E-2
2.645E-1
 2 10
24 umls:C0030567 Parkinson Disease DisGeNET Curated 2.220E-4 1.278E-2
9.977E-2
3.067E-1
 6 422
25 umls:C0262655 Recurrent urinary tract infection DisGeNET BeFree 2.338E-4 1.292E-2
1.008E-1
3.229E-1
 2 11
26 umls:C0027765 nervous system disorder DisGeNET Curated 2.648E-4 1.354E-2
1.057E-1
3.656E-1
 6 436
27 umls:C1269683 Major Depressive Disorder DisGeNET Curated 2.648E-4 1.354E-2
1.057E-1
3.656E-1
 6 436
28 umls:C1561643 Chronic Kidney Diseases DisGeNET Curated 2.974E-4 1.467E-2
1.145E-1
4.107E-1
 5 284
29 umls:C0011269 Dementia, Vascular DisGeNET Curated 3.253E-4 1.549E-2
1.210E-1
4.493E-1
 3 64
30 umls:C0085580 Essential Hypertension DisGeNET Curated 3.826E-4 1.761E-2
1.375E-1
5.284E-1
 5 300
31 umls:C3495426 Homocysteinemia DisGeNET BeFree 4.794E-4 1.964E-2
1.534E-1
6.621E-1
 3 73
32 umls:C0015695 Fatty Liver DisGeNET Curated 4.922E-4 1.964E-2
1.534E-1
6.797E-1
 5 317
33 umls:C1096293 Macroangiopathy DisGeNET BeFree 5.068E-4 1.964E-2
1.534E-1
6.999E-1
 2 16
34 umls:C0005411 Biliary Atresia DisGeNET Curated 5.396E-4 1.964E-2
1.534E-1
7.452E-1
 3 76
35 umls:C1559271 Non-Malignant Ascites Adverse Event DisGeNET BeFree 5.442E-4 1.964E-2
1.534E-1
7.516E-1
 4 181
36 umls:C1854310 Hypotrichosis simplex DisGeNET Curated 5.736E-4 1.964E-2
1.534E-1
7.921E-1
 2 17
37 umls:C0497327 Dementia DisGeNET Curated 6.411E-4 1.964E-2
1.534E-1
8.854E-1
 5 336
38 umls:C0271160 Cortical cataract DisGeNET BeFree 6.444E-4 1.964E-2
1.534E-1
8.900E-1
 2 18
39 umls:C0278488 Carcinoma breast stage IV DisGeNET BeFree 6.854E-4 1.964E-2
1.534E-1
9.465E-1
 5 341
40 umls:C0751633 Carotid Artery Plaque DisGeNET BeFree 7.193E-4 1.964E-2
1.534E-1
9.934E-1
 2 19
41 umls:C0042373 Vascular Diseases DisGeNET Curated 7.320E-4 1.964E-2
1.534E-1
1.000E0
 5 346
42 umls:C0086543 Cataract DisGeNET Curated 7.337E-4 1.964E-2
1.534E-1
1.000E0
 4 196
43 umls:C1719672 Severe Sepsis DisGeNET BeFree 7.484E-4 1.964E-2
1.534E-1
1.000E0
 3 85
44 umls:C0007766 Intracranial Aneurysm DisGeNET Curated 8.555E-4 1.964E-2
1.534E-1
1.000E0
 3 89
45 umls:C0008031 Chest Pain DisGeNET Curated 8.810E-4 1.964E-2
1.534E-1
1.000E0
 2 21
46 umls:C0003486 Aortic Aneurysm DisGeNET Curated 8.995E-4 1.964E-2
1.534E-1
1.000E0
 4 207
47 umls:C0155733 Atherosclerosis of aorta DisGeNET BeFree 9.679E-4 1.964E-2
1.534E-1
1.000E0
 2 22
48 umls:C0040128 Thyroid Diseases DisGeNET Curated 9.720E-4 1.964E-2
1.534E-1
1.000E0
 3 93
49 umls:C0025517 Metabolic Diseases DisGeNET Curated 9.892E-4 1.964E-2
1.534E-1
1.000E0
 5 370
50 umls:C0003469 Anxiety Disorders DisGeNET Curated 1.001E-3 1.964E-2
1.534E-1
1.000E0
 5 371
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