Toppgene analysis for aggregated_1964_log, IC4, positive side

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1: GO: Molecular Function [Display Chart] 940 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016651 oxidoreductase activity, acting on NAD(P)H 6.909E-8 6.494E-5 4.821E-4 6.494E-5 13 103
2 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 1.598E-7 7.510E-5 5.575E-4 1.502E-4 10 60
3 GO:0043021 ribonucleoprotein complex binding 3.607E-6 9.683E-4 7.188E-3 3.390E-3 12 123
4 GO:0046977 TAP binding 4.120E-6 9.683E-4 7.188E-3 3.873E-3 4 7
5 GO:0003735 structural constituent of ribosome 1.543E-5 2.628E-3 1.951E-2 1.450E-2 15 216
6 GO:0050136 NADH dehydrogenase (quinone) activity 2.236E-5 2.628E-3 1.951E-2 2.102E-2 7 46
7 GO:0008137 NADH dehydrogenase (ubiquinone) activity 2.236E-5 2.628E-3 1.951E-2 2.102E-2 7 46
8 GO:0003954 NADH dehydrogenase activity 2.236E-5 2.628E-3 1.951E-2 2.102E-2 7 46
9 GO:0042605 peptide antigen binding 2.545E-5 2.658E-3 1.973E-2 2.392E-2 6 32
10 GO:0051539 4 iron, 4 sulfur cluster binding 1.095E-4 1.029E-2
7.642E-2
1.029E-1
 6 41
11 GO:0051082 unfolded protein binding 1.414E-4 1.208E-2
8.970E-2
1.329E-1
 9 103
12 GO:0051536 iron-sulfur cluster binding 1.943E-4 1.405E-2
1.043E-1
1.826E-1
 7 64
13 GO:0051540 metal cluster binding 1.943E-4 1.405E-2
1.043E-1
1.826E-1
 7 64
14 GO:0048037 cofactor binding 2.668E-4 1.792E-2
1.330E-1
2.508E-1
 15 278
15 GO:0008135 translation factor activity, RNA binding 2.937E-4 1.840E-2
1.366E-1
2.761E-1
 8 90
16 GO:0008665 2'-phosphotransferase activity 3.529E-4 1.951E-2
1.448E-1
3.317E-1
 2 2
17 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity 3.529E-4 1.951E-2
1.448E-1
3.317E-1
 2 2
18 GO:0016662 oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor 5.096E-4 2.661E-2
1.976E-1
4.790E-1
 3 9
19 GO:0032182 ubiquitin-like protein binding 6.739E-4 3.334E-2
2.475E-1
6.334E-1
 9 127
20 GO:0017070 U6 snRNA binding 9.734E-4 4.257E-2
3.160E-1
9.150E-1
 3 11
21 GO:0030881 beta-2-microglobulin binding 9.734E-4 4.257E-2
3.160E-1
9.150E-1
 3 11
22 GO:0043130 ubiquitin binding 9.964E-4 4.257E-2
3.160E-1
9.366E-1
 8 108
23 GO:0030519 snoRNP binding 1.045E-3 4.272E-2
3.172E-1
9.827E-1
 2 3
24 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1.280E-3 4.987E-2
3.702E-1
1.000E0
 3 12
25 GO:0019200 carbohydrate kinase activity 1.326E-3 4.987E-2
3.702E-1
1.000E0
 4 26
Show 20 more annotations

2: GO: Biological Process [Display Chart] 3899 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0022904 respiratory electron transport chain 7.669E-8 2.105E-4 1.862E-3 2.990E-4 13 104
2 GO:0022900 electron transport chain 1.080E-7 2.105E-4 1.862E-3 4.209E-4 13 107
3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone 2.795E-7 2.789E-4 2.467E-3 1.090E-3 9 49
4 GO:0045333 cellular respiration 2.861E-7 2.789E-4 2.467E-3 1.116E-3 16 179
5 GO:0042775 mitochondrial ATP synthesis coupled electron transport 3.757E-7 2.873E-4 2.542E-3 1.465E-3 11 82
6 GO:0009119 ribonucleoside metabolic process 4.421E-7 2.873E-4 2.542E-3 1.724E-3 24 392
7 GO:0042773 ATP synthesis coupled electron transport 5.445E-7 3.033E-4 2.683E-3 2.123E-3 11 85
8 GO:1901657 glycosyl compound metabolic process 8.529E-7 3.254E-4 2.879E-3 3.326E-3 25 436
9 GO:0010257 NADH dehydrogenase complex assembly 9.182E-7 3.254E-4 2.879E-3 3.580E-3 9 56
10 GO:0032981 mitochondrial respiratory chain complex I assembly 9.182E-7 3.254E-4 2.879E-3 3.580E-3 9 56
11 GO:0097031 mitochondrial respiratory chain complex I biogenesis 9.182E-7 3.254E-4 2.879E-3 3.580E-3 9 56
12 GO:0009116 nucleoside metabolic process 1.171E-6 3.804E-4 3.365E-3 4.565E-3 24 414
13 GO:0046128 purine ribonucleoside metabolic process 1.522E-6 4.439E-4 3.926E-3 5.933E-3 22 362
14 GO:0033108 mitochondrial respiratory chain complex assembly 1.735E-6 4.439E-4 3.926E-3 6.765E-3 10 77
15 GO:0042278 purine nucleoside metabolic process 1.743E-6 4.439E-4 3.926E-3 6.797E-3 22 365
16 GO:0006091 generation of precursor metabolites and energy 1.821E-6 4.439E-4 3.926E-3 7.102E-3 23 395
17 GO:0032543 mitochondrial translation 2.751E-6 6.309E-4 5.581E-3 1.073E-2 12 120
18 GO:0034976 response to endoplasmic reticulum stress 2.956E-6 6.403E-4 5.664E-3 1.152E-2 18 265
19 GO:0009141 nucleoside triphosphate metabolic process 3.431E-6 6.751E-4 5.972E-3 1.338E-2 19 295
20 GO:0043241 protein complex disassembly 3.463E-6 6.751E-4 5.972E-3 1.350E-2 18 268
21 GO:0009199 ribonucleoside triphosphate metabolic process 3.843E-6 7.136E-4 6.312E-3 1.499E-2 18 270
22 GO:0042270 protection from natural killer cell mediated cytotoxicity 4.103E-6 7.272E-4 6.433E-3 1.600E-2 4 7
23 GO:0009123 nucleoside monophosphate metabolic process 5.304E-6 8.992E-4 7.954E-3 2.068E-2 19 304
24 GO:0006119 oxidative phosphorylation 5.993E-6 9.459E-4 8.367E-3 2.337E-2 11 108
25 GO:0032984 macromolecular complex disassembly 6.065E-6 9.459E-4 8.367E-3 2.365E-2 18 279
26 GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent 6.581E-6 9.868E-4 8.729E-3 2.566E-2 3 3
27 GO:0002483 antigen processing and presentation of endogenous peptide antigen 8.390E-6 1.203E-3 1.064E-2 3.271E-2 5 16
28 GO:0006414 translational elongation 8.692E-6 1.203E-3 1.064E-2 3.389E-2 12 134
29 GO:0015980 energy derivation by oxidation of organic compounds 8.947E-6 1.203E-3 1.064E-2 3.488E-2 18 287
30 GO:0009205 purine ribonucleoside triphosphate metabolic process 1.072E-5 1.359E-3 1.202E-2 4.179E-2 17 263
31 GO:0009161 ribonucleoside monophosphate metabolic process 1.081E-5 1.359E-3 1.202E-2 4.213E-2 18 291
32 GO:0043624 cellular protein complex disassembly 1.365E-5 1.644E-3 1.454E-2
5.321E-2
 15 214
33 GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway 1.434E-5 1.644E-3 1.454E-2
5.590E-2
 4 9
34 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent 1.434E-5 1.644E-3 1.454E-2
5.590E-2
 4 9
35 GO:0009144 purine nucleoside triphosphate metabolic process 1.582E-5 1.763E-3 1.559E-2
6.169E-2
 17 271
36 GO:0006415 translational termination 1.710E-5 1.804E-3 1.595E-2
6.667E-2
 10 99
37 GO:0072595 maintenance of protein localization in organelle 1.711E-5 1.804E-3 1.595E-2
6.673E-2
 6 30
38 GO:0019883 antigen processing and presentation of endogenous antigen 2.132E-5 2.188E-3 1.935E-2
8.313E-2
 5 19
39 GO:0009167 purine ribonucleoside monophosphate metabolic process 2.299E-5 2.299E-3 2.034E-2
8.966E-2
 17 279
40 GO:0009126 purine nucleoside monophosphate metabolic process 2.407E-5 2.346E-3 2.075E-2
9.385E-2
 17 280
41 GO:0006446 regulation of translational initiation 2.812E-5 2.674E-3 2.365E-2
1.096E-1
 9 84
42 GO:0070125 mitochondrial translational elongation 3.093E-5 2.872E-3 2.540E-2
1.206E-1
 9 85
43 GO:0051651 maintenance of location in cell 3.661E-5 3.320E-3 2.937E-2
1.428E-1
 10 108
44 GO:0046034 ATP metabolic process 5.706E-5 5.056E-3 4.473E-2
2.225E-1
 15 242
45 GO:0061136 regulation of proteasomal protein catabolic process 6.194E-5 5.367E-3 4.747E-2
2.415E-1
 13 189
46 GO:0034470 ncRNA processing 7.276E-5 6.084E-3
5.382E-2
2.837E-1
 20 399
47 GO:0002478 antigen processing and presentation of exogenous peptide antigen 7.344E-5 6.084E-3
5.382E-2
2.863E-1
 12 166
48 GO:0032507 maintenance of protein location in cell 7.490E-5 6.084E-3
5.382E-2
2.920E-1
 9 95
49 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 1.057E-4 8.412E-3
7.441E-2
4.122E-1
 4 14
50 GO:0019884 antigen processing and presentation of exogenous antigen 1.091E-4 8.505E-3
7.524E-2
4.253E-1
 12 173
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 549 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005759 mitochondrial matrix 2.058E-11 1.130E-8 7.781E-8 1.130E-8 32 425
2 GO:0098798 mitochondrial protein complex 2.052E-8 5.631E-6 3.878E-5 1.126E-5 16 150
3 GO:1990204 oxidoreductase complex 3.253E-8 5.952E-6 4.099E-5 1.786E-5 13 98
4 GO:0098800 inner mitochondrial membrane protein complex 1.809E-7 2.483E-5 1.710E-4 9.932E-5 13 113
5 GO:0098803 respiratory chain complex 4.800E-7 5.270E-5 3.629E-4 2.635E-4 10 68
6 GO:0030964 NADH dehydrogenase complex 1.075E-6 7.374E-5 5.078E-4 5.899E-4 8 43
7 GO:0045271 respiratory chain complex I 1.075E-6 7.374E-5 5.078E-4 5.899E-4 8 43
8 GO:0005747 mitochondrial respiratory chain complex I 1.075E-6 7.374E-5 5.078E-4 5.899E-4 8 43
9 GO:0005746 mitochondrial respiratory chain 1.220E-6 7.440E-5 5.123E-4 6.696E-4 10 75
10 GO:0098576 lumenal side of membrane 2.023E-6 1.110E-4 7.647E-4 1.110E-3 7 33
11 GO:0044455 mitochondrial membrane part 2.619E-6 1.307E-4 9.002E-4 1.438E-3 15 189
12 GO:0070469 respiratory chain 6.579E-6 2.825E-4 1.945E-3 3.612E-3 10 90
13 GO:0043209 myelin sheath 6.689E-6 2.825E-4 1.945E-3 3.672E-3 15 204
14 GO:0030176 integral component of endoplasmic reticulum membrane 9.700E-6 3.804E-4 2.619E-3 5.325E-3 12 137
15 GO:0031227 intrinsic component of endoplasmic reticulum membrane 1.398E-5 5.115E-4 3.523E-3 7.673E-3 12 142
16 GO:0031301 integral component of organelle membrane 2.379E-5 8.164E-4 5.622E-3 1.306E-2 17 283
17 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 2.818E-5 9.101E-4 6.267E-3 1.547E-2 10 106
18 GO:0042612 MHC class I protein complex 3.480E-5 1.061E-3 7.308E-3 1.910E-2 4 11
19 GO:0031300 intrinsic component of organelle membrane 4.197E-5 1.213E-3 8.350E-3 2.304E-2 17 296
20 GO:0030137 COPI-coated vesicle 5.484E-5 1.505E-3 1.037E-2 3.010E-2 5 23
21 GO:0030662 coated vesicle membrane 7.077E-5 1.850E-3 1.274E-2 3.885E-2 11 142
22 GO:0005761 mitochondrial ribosome 1.082E-4 2.583E-3 1.778E-2
5.940E-2
 8 79
23 GO:0000313 organellar ribosome 1.082E-4 2.583E-3 1.778E-2
5.940E-2
 8 79
24 GO:0030670 phagocytic vesicle membrane 1.323E-4 3.026E-3 2.084E-2
7.262E-2
 7 61
25 GO:0097526 spliceosomal tri-snRNP complex 1.484E-4 3.259E-3 2.244E-2
8.147E-2
 5 28
26 GO:0030135 coated vesicle 1.756E-4 3.463E-3 2.385E-2
9.640E-2
 14 241
27 GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane 1.766E-4 3.463E-3 2.385E-2
9.696E-2
 5 29
28 GO:0098553 lumenal side of endoplasmic reticulum membrane 1.766E-4 3.463E-3 2.385E-2
9.696E-2
 5 29
29 GO:0030133 transport vesicle 2.369E-4 4.485E-3 3.088E-2
1.301E-1
 18 374
30 GO:0005741 mitochondrial outer membrane 3.823E-4 6.995E-3 4.817E-2
2.099E-1
 11 172
31 GO:0012507 ER to Golgi transport vesicle membrane 5.292E-4 9.372E-3
6.454E-2
2.905E-1
 6 55
32 GO:0030666 endocytic vesicle membrane 7.204E-4 1.236E-2
8.510E-2
3.955E-1
 10 157
33 GO:0005798 Golgi-associated vesicle 1.097E-3 1.826E-2
1.257E-1
6.024E-1
 7 86
34 GO:0031968 organelle outer membrane 1.179E-3 1.903E-2
1.311E-1
6.471E-1
 11 197
35 GO:0034663 endoplasmic reticulum chaperone complex 1.233E-3 1.934E-2
1.332E-1
6.770E-1
 3 12
36 GO:0045335 phagocytic vesicle 1.342E-3 2.047E-2
1.410E-1
7.369E-1
 7 89
37 GO:0042611 MHC protein complex 1.463E-3 2.171E-2
1.495E-1
8.034E-1
 4 27
38 GO:0005840 ribosome 1.543E-3 2.195E-2
1.511E-1
8.473E-1
 12 235
39 GO:0019867 outer membrane 1.559E-3 2.195E-2
1.511E-1
8.560E-1
 11 204
40 GO:0044452 nucleolar part 1.897E-3 2.604E-2
1.793E-1
1.000E0
 6 70
41 GO:0030134 ER to Golgi transport vesicle 2.040E-3 2.732E-2
1.881E-1
1.000E0
 6 71
42 GO:0097525 spliceosomal snRNP complex 3.221E-3 4.029E-2
2.774E-1
1.000E0
 5 54
43 GO:0000502 proteasome complex 3.285E-3 4.029E-2
2.774E-1
1.000E0
 6 78
44 GO:0097413 Lewy body 3.313E-3 4.029E-2
2.774E-1
1.000E0
 2 5
45 GO:0010008 endosome membrane 3.391E-3 4.029E-2
2.774E-1
1.000E0
 16 399
46 GO:0048770 pigment granule 3.449E-3 4.029E-2
2.774E-1
1.000E0
 7 105
47 GO:0042470 melanosome 3.449E-3 4.029E-2
2.774E-1
1.000E0
 7 105
48 GO:0030663 COPI-coated vesicle membrane 3.558E-3 4.069E-2
2.802E-1
1.000E0
 3 17
Show 43 more annotations

4: Human Phenotype [Display Chart] 935 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0002151 Increased serum lactate 1.813E-5 1.695E-2
1.258E-1
 1.695E-2 10 97

5: Mouse Phenotype [Display Chart] 2428 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0006036 abnormal mitochondrial physiology 1.645E-5 3.993E-2
3.343E-1
 3.993E-2 13 162

6: Domain [Display Chart] 1685 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF06623 MHC I C Pfam 1.804E-6 1.520E-3 1.217E-2 3.040E-3 4 6
2 IPR010579 MHC I a C InterPro 1.804E-6 1.520E-3 1.217E-2 3.040E-3 4 6
3 IPR000626 Ubiquitin dom InterPro 1.237E-5 6.949E-3
5.564E-2
 2.085E-2 8 58
4 PF00129 MHC I Pfam 3.664E-5 1.235E-2
9.886E-2
6.173E-2
 5 21
5 IPR001039 MHC I a a1/a2 InterPro 3.664E-5 1.235E-2
9.886E-2
6.173E-2
 5 21
6 PS50053 UBIQUITIN 2 PROSITE 6.571E-5 1.539E-2
1.232E-1
1.107E-1
 7 54
7 IPR011161 MHC I-like Ag-recog InterPro 7.305E-5 1.539E-2
1.232E-1
1.231E-1
 5 24
8 3.30.500.10 - Gene3D 7.305E-5 1.539E-2
1.232E-1
1.231E-1
 5 24
9 SM00213 UBQ SMART 1.451E-4 2.717E-2
2.176E-1
2.446E-1
 6 43
10 SM00165 UBA SMART 2.232E-4 3.676E-2
2.943E-1
3.761E-1
 5 30
11 PF00240 ubiquitin Pfam 2.400E-4 3.676E-2
2.943E-1
4.043E-1
 6 47
12 PF02630 SCO1-SenC Pfam 3.540E-4 3.977E-2
3.184E-1
5.965E-1
 2 2
13 IPR005578 Yif1 fam InterPro 3.540E-4 3.977E-2
3.184E-1
5.965E-1
 2 2
14 IPR017276 Synth of cyt-c-oxidase Sco1/2 InterPro 3.540E-4 3.977E-2
3.184E-1
5.965E-1
 2 2
15 IPR003782 SCO1/SenC InterPro 3.540E-4 3.977E-2
3.184E-1
5.965E-1
 2 2
Show 10 more annotations

7: Pathway [Display Chart] 1266 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 477137 The citric acid (TCA) cycle and respiratory electron transport BioSystems: REACTOME 5.534E-7 7.006E-4 5.410E-3 7.006E-4 14 136
2 160962 Respiratory electron transport BioSystems: REACTOME 3.701E-6 1.676E-3 1.294E-2 4.685E-3 10 79
3 83100 Huntington's disease BioSystems: KEGG 3.972E-6 1.676E-3 1.294E-2 5.028E-3 15 183
4 83097 Alzheimer's disease BioSystems: KEGG 6.933E-6 2.183E-3 1.685E-2 8.778E-3 14 168
5 198860 Electron Transport Chain BioSystems: WikiPathways 8.621E-6 2.183E-3 1.685E-2 1.091E-2 11 106
6 82942 Oxidative phosphorylation BioSystems: KEGG 1.428E-5 2.963E-3 2.288E-2 1.808E-2 12 133
7 198803 Translation Factors BioSystems: WikiPathways 1.638E-5 2.963E-3 2.288E-2 2.074E-2 8 57
8 105921 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. BioSystems: REACTOME 2.359E-5 3.733E-3 2.883E-2 2.987E-2 10 97
9 198870 Oxidative phosphorylation BioSystems: WikiPathways 3.076E-5 4.326E-3 3.340E-2 3.894E-2 8 62
10 477125 Endosomal/Vacuolar pathway BioSystems: REACTOME 4.657E-5 5.896E-3 4.552E-2
5.896E-2
 4 11
11 83098 Parkinson's disease BioSystems: KEGG 6.349E-5 7.307E-3
5.642E-2
8.037E-2
 11 131
12 153910 Phagosome BioSystems: KEGG 7.897E-5 8.332E-3
6.433E-2
9.998E-2
 12 158
13 366163 Antigen Presentation: Folding, assembly and peptide loading of class I MHC BioSystems: REACTOME 9.667E-5 9.414E-3
7.269E-2
1.224E-1
 5 24
14 167325 Protein processing in endoplasmic reticulum BioSystems: KEGG 1.342E-4 1.214E-2
9.372E-2
1.699E-1
 12 167
15 862188 Non-alcoholic fatty liver disease (NAFLD) BioSystems: KEGG 2.264E-4 1.911E-2
1.476E-1
2.867E-1
 11 151
16 477124 ER-Phagosome pathway BioSystems: REACTOME 3.082E-4 2.438E-2
1.883E-1
3.901E-1
 7 65
17 106248 Post-chaperonin tubulin folding pathway BioSystems: REACTOME 4.821E-4 3.590E-2
2.772E-1
6.103E-1
 4 19
18 576261 Mitochondrial Protein Import BioSystems: REACTOME 6.363E-4 4.476E-2
3.456E-1
8.056E-1
 6 53
19 83101 Vibrio cholerae infection BioSystems: KEGG 7.041E-4 4.691E-2
3.622E-1
8.914E-1
 6 54
Show 14 more annotations

8: Pubmed [Display Chart] 32251 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 22190034 Global landscape of HIV-human protein complexes. Pubmed 2.537E-30 8.183E-26 8.968E-25 8.183E-26 39 457
2 15231747 A protein interaction framework for human mRNA degradation. Pubmed 8.488E-30 1.369E-25 1.500E-24 2.738E-25 35 347
3 24797263 Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. Pubmed 7.600E-26 8.170E-22 8.953E-21 2.451E-21 31 323
4 27499296 Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. Pubmed 5.090E-25 4.104E-21 4.497E-20 1.642E-20 33 409
5 26549023 The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. Pubmed 2.917E-21 1.881E-17 2.062E-16 9.406E-17 28 351
6 25324306 hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. Pubmed 2.696E-20 1.449E-16 1.588E-15 8.695E-16 27 346
7 25147182 Quantitative Lys-¿-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. Pubmed 1.026E-19 4.728E-16 5.181E-15 3.310E-15 28 401
8 20186120 A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. Pubmed 1.187E-19 4.786E-16 5.245E-15 3.829E-15 22 207
9 24778252 TRIM65 regulates microRNA activity by ubiquitination of TNRC6. Pubmed 1.235E-18 4.426E-15 4.850E-14 3.983E-14 26 364
10 16303743 Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Pubmed 6.972E-18 2.249E-14 2.464E-13 2.249E-13 27 430
11 20833797 Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Pubmed 1.552E-17 4.550E-14 4.987E-13 5.005E-13 15 81
12 22623428 Proteomic analysis of ¿4�1 integrin adhesion complexes reveals ¿-subunit-dependent protein recruitment. Pubmed 2.040E-17 5.483E-14 6.009E-13 6.580E-13 28 491
13 16196087 Large-scale analysis of the human ubiquitin-related proteome. Pubmed 6.760E-17 1.677E-13 1.838E-12 2.180E-12 23 313
14 21319273 An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. Pubmed 1.119E-16 2.578E-13 2.825E-12 3.609E-12 25 397
15 12665801 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Pubmed 2.690E-16 5.783E-13 6.338E-12 8.675E-12 21 262
16 26389662 Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis. Pubmed 7.086E-16 1.428E-12 1.565E-11 2.285E-11 19 209
17 23246001 SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. Pubmed 8.379E-15 1.590E-11 1.742E-10 2.702E-10 19 239
18 22678362 MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. Pubmed 1.131E-14 2.026E-11 2.220E-10 3.647E-10 16 150
19 24189400 Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms. Pubmed 2.923E-14 4.962E-11 5.438E-10 9.428E-10 19 256
20 23798571 Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. Pubmed 3.149E-14 5.077E-11 5.564E-10 1.015E-9 16 160
21 21139048 Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Pubmed 7.046E-14 1.082E-10 1.186E-9 2.272E-9 18 233
22 23455922 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Pubmed 1.370E-13 2.009E-10 2.201E-9 4.419E-9 23 447
23 19199708 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Pubmed 2.471E-13 3.464E-10 3.796E-9 7.968E-9 22 414
24 23402259 Quantitative study of the interactome of PKC¿ involved in the EGF-induced tumor cell chemotaxis. Pubmed 2.816E-13 3.784E-10 4.147E-9 9.082E-9 16 184
25 23824909 Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. Pubmed 3.031E-13 3.895E-10 4.269E-9 9.776E-9 21 374
26 15635413 Nucleolar proteome dynamics. Pubmed 3.140E-13 3.895E-10 4.269E-9 1.013E-8 22 419
27 21081666 Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Pubmed 4.037E-13 4.822E-10 5.284E-9 1.302E-8 18 258
28 16712791 Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Pubmed 1.134E-12 1.287E-9 1.410E-8 3.658E-8 22 447
29 25476789 Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. Pubmed 1.167E-12 1.287E-9 1.410E-8 3.765E-8 14 139
30 24344204 TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. Pubmed 1.197E-12 1.287E-9 1.410E-8 3.861E-8 13 112
31 21890473 A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Pubmed 2.010E-12 2.091E-9 2.291E-8 6.481E-8 16 209
32 25036637 A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Pubmed 2.168E-12 2.185E-9 2.394E-8 6.991E-8 19 326
33 23956138 Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. Pubmed 3.706E-12 3.622E-9 3.969E-8 1.195E-7 15 183
34 20562859 Network organization of the human autophagy system. Pubmed 4.713E-12 4.471E-9 4.899E-8 1.520E-7 21 432
35 25659154 ABCE1 is a highly conserved RNA silencing suppressor. Pubmed 1.766E-11 1.627E-8 1.783E-7 5.695E-7 15 204
36 15057824 The DNA sequence and biology of human chromosome 19. Pubmed 1.866E-11 1.672E-8 1.832E-7 6.018E-7 17 282
37 11790298 Directed proteomic analysis of the human nucleolus. Pubmed 2.329E-11 2.030E-8 2.224E-7 7.511E-7 15 208
38 18977241:gr Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. GeneRIF 4.323E-11 3.575E-8 3.917E-7 1.394E-6 12 118
39 18977241 Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. Pubmed 4.323E-11 3.575E-8 3.917E-7 1.394E-6 12 118
40 17601350:gr A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. GeneRIF 4.778E-11 3.680E-8 4.033E-7 1.541E-6 12 119
41 17601350 A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. Pubmed 4.778E-11 3.680E-8 4.033E-7 1.541E-6 12 119
42 17643375 Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Pubmed 4.792E-11 3.680E-8 4.033E-7 1.546E-6 19 390
43 25852190 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Pubmed 7.686E-11 5.764E-8 6.317E-7 2.479E-6 19 401
44 26499835 Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data. Pubmed 9.133E-11 6.694E-8 7.336E-7 2.946E-6 9 52
45 12611891 The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. Pubmed 1.548E-10 1.110E-7 1.216E-6 4.993E-6 8 37
46 23874603 HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis. Pubmed 2.110E-10 1.479E-7 1.621E-6 6.805E-6 12 135
47 26752685 FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. Pubmed 2.300E-10 1.578E-7 1.729E-6 7.417E-6 12 136
48 15308636 Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. Pubmed 3.046E-10 2.043E-7 2.239E-6 9.825E-6 7 25
49 18057255 Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit. Pubmed 3.168E-10 2.043E-7 2.239E-6 1.022E-5 5 7
50 9586638 Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. Pubmed 3.168E-10 2.043E-7 2.239E-6 1.022E-5 5 7
Show 45 more annotations

9: Interaction [Display Chart] 6688 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:MRPL58 MRPL58 interactions 2.604E-12 1.741E-8 1.634E-7 1.741E-8 27 244
2 int:TCTN2 TCTN2 interactions 1.697E-10 5.676E-7 5.327E-6 1.135E-6 23 212
3 int:NDUFS3 NDUFS3 interactions 3.401E-9 7.582E-6 7.116E-5 2.275E-5 18 150
4 int:TCTN3 TCTN3 interactions 4.825E-9 8.067E-6 7.572E-5 3.227E-5 26 317
5 int:NDUFA4 NDUFA4 interactions 1.288E-8 1.723E-5 1.618E-4 8.617E-5 18 163
6 int:PPME1 PPME1 interactions 6.568E-8 7.321E-5 6.871E-4 4.393E-4 13 91
7 int:NDUFS5 NDUFS5 interactions 1.235E-7 1.180E-4 1.108E-3 8.262E-4 10 52
8 int:MMS19 MMS19 interactions 1.629E-7 1.362E-4 1.278E-3 1.090E-3 18 192
9 int:CYC1 CYC1 interactions 5.195E-7 3.860E-4 3.623E-3 3.474E-3 11 75
10 int:NDUFAF3 NDUFAF3 interactions 8.966E-7 5.997E-4 5.628E-3 5.997E-3 8 37
11 int:MRPL46 MRPL46 interactions 1.115E-6 6.778E-4 6.361E-3 7.456E-3 8 38
12 int:NDUFA12 NDUFA12 interactions 1.677E-6 9.029E-4 8.474E-3 1.122E-2 10 68
13 int:RAB1A RAB1A interactions 1.814E-6 9.029E-4 8.474E-3 1.213E-2 14 140
14 int:C15orf48 C15orf48 interactions 1.890E-6 9.029E-4 8.474E-3 1.264E-2 13 121
15 int:SDHB SDHB interactions 2.967E-6 1.236E-3 1.160E-2 1.984E-2 11 89
16 int:NDUFS7 NDUFS7 interactions 3.012E-6 1.236E-3 1.160E-2 2.014E-2 8 43
17 int:FAF2 FAF2 interactions 3.142E-6 1.236E-3 1.160E-2 2.101E-2 18 235
18 int:MRPS30 MRPS30 interactions 3.699E-6 1.374E-3 1.290E-2 2.474E-2 10 74
19 int:MRPL13 MRPL13 interactions 4.082E-6 1.397E-3 1.311E-2 2.730E-2 9 59
20 int:BAG3 BAG3 interactions 4.179E-6 1.397E-3 1.311E-2 2.795E-2 26 448
21 int:RPS6KB2 RPS6KB2 interactions 5.620E-6 1.790E-3 1.680E-2 3.759E-2 16 198
22 int:GLS GLS interactions 6.237E-6 1.896E-3 1.780E-2 4.172E-2 7 34
23 int:UBL4A UBL4A interactions 6.717E-6 1.953E-3 1.833E-2 4.493E-2 20 298
24 int:HUWE1 HUWE1 interactions 7.249E-6 1.969E-3 1.848E-2 4.848E-2 26 462
25 int:NDUFA9 NDUFA9 interactions 7.569E-6 1.969E-3 1.848E-2
5.062E-2
 10 80
26 int:MRPL17 MRPL17 interactions 7.655E-6 1.969E-3 1.848E-2
5.120E-2
 7 35
27 int:PSMD4 PSMD4 interactions 1.007E-5 2.495E-3 2.342E-2
6.737E-2
 14 162
28 int:MRPL4 MRPL4 interactions 1.081E-5 2.498E-3 2.345E-2
7.228E-2
 12 121
29 int:ADRB2 ADRB2 interactions 1.090E-5 2.498E-3 2.345E-2
7.288E-2
 18 257
30 int:NDUFAF4 NDUFAF4 interactions 1.130E-5 2.498E-3 2.345E-2
7.556E-2
 7 37
31 int:CD2BP2 CD2BP2 interactions 1.195E-5 2.498E-3 2.345E-2
7.995E-2
 9 67
32 int:LMAN1 LMAN1 interactions 1.195E-5 2.498E-3 2.345E-2
7.995E-2
 9 67
33 int:VAPA VAPA interactions 1.258E-5 2.550E-3 2.394E-2
8.416E-2
 16 211
34 int:HERC2 HERC2 interactions 1.335E-5 2.598E-3 2.438E-2
8.929E-2
 16 212
35 int:NDUFB10 NDUFB10 interactions 1.360E-5 2.598E-3 2.438E-2
9.094E-2
 7 38
36 int:NDUFV1 NDUFV1 interactions 1.453E-5 2.646E-3 2.483E-2
9.720E-2
 10 86
37 int:CUL2 CUL2 interactions 1.464E-5 2.646E-3 2.483E-2
9.789E-2
 25 452
38 int:ARF1 ARF1 interactions 1.611E-5 2.828E-3 2.654E-2
1.078E-1
 10 87
39 int:CREB3 CREB3 interactions 1.649E-5 2.828E-3 2.654E-2
1.103E-1
 15 192
40 int:NDUFS8 NDUFS8 interactions 1.762E-5 2.889E-3 2.711E-2
1.178E-1
 8 54
41 int:SRPRB SRPRB interactions 1.771E-5 2.889E-3 2.711E-2
1.184E-1
 12 127
42 int:TIMMDC1 TIMMDC1 interactions 2.023E-5 3.215E-3 3.017E-2
1.353E-1
 8 55
43 int:ILK ILK interactions 2.115E-5 3.215E-3 3.017E-2
1.415E-1
 16 220
44 int:UBQLN1 UBQLN1 interactions 2.115E-5 3.215E-3 3.017E-2
1.415E-1
 16 220
45 int:SDHA SDHA interactions 2.177E-5 3.236E-3 3.037E-2
1.456E-1
 10 90
46 int:NDUFA11 NDUFA11 interactions 2.293E-5 3.270E-3 3.069E-2
1.533E-1
 7 41
47 int:LMAN2 LMAN2 interactions 2.298E-5 3.270E-3 3.069E-2
1.537E-1
 6 28
48 int:PKM PKM interactions 2.417E-5 3.368E-3 3.161E-2
1.617E-1
 14 175
49 int:RAD23B RAD23B interactions 2.755E-5 3.760E-3 3.529E-2
1.843E-1
 11 112
50 int:NF2 NF2 interactions 2.998E-5 4.011E-3 3.764E-2
2.005E-1
 15 202
Show 45 more annotations

10: Cytoband [Display Chart] 185 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11q13 11q13 4.643E-8 4.793E-6 2.780E-5 8.590E-6 11 119
2 19p13.3 19p13.3 5.181E-8 4.793E-6 2.780E-5 9.586E-6 15 247
3 19p13.11 19p13.11 1.502E-5 9.263E-4 5.373E-3 2.779E-3 7 77
4 19p13.2 19p13.2 3.644E-5 1.685E-3 9.775E-3 6.741E-3 11 235
5 20p13 20p13 9.261E-5 3.426E-3 1.987E-2 1.713E-2 7 102
6 9q34 9q34 2.356E-4 6.258E-3 3.630E-2 4.359E-2 5 54
7 19q13.3 19q13.3 2.368E-4 6.258E-3 3.630E-2 4.381E-2 6 84
8 9q34.11 9q34.11 3.576E-4 8.270E-3 4.797E-2
6.616E-2
 5 59
9 17q25 17q25 6.847E-4 1.408E-2
8.164E-2
1.267E-1
 4 39
10 7p13 7p13 8.296E-4 1.535E-2
8.902E-2
1.535E-1
 4 41
11 8q24.3 8q24.3 2.083E-3 3.504E-2
2.032E-1
3.854E-1
 6 127
Show 6 more annotations

11: Transcription Factor Binding Site [Display Chart] 472 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$ELK1 02 V$ELK1 02 2.983E-6 1.408E-3 9.483E-3 1.408E-3 15 185

12: Gene Family [Display Chart] 138 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 646 Mitochondrial ribosomal proteins genenames.org 2.053E-6 2.833E-4 1.560E-3 2.833E-4 8 79
2 1149 NADH:ubiquinone oxidoreductase core subunits genenames.org 1.178E-5 5.490E-4 3.024E-3 1.625E-3 4 14
3 1144 YIP family genenames.org 1.193E-5 5.490E-4 3.024E-3 1.647E-3 3 5
4 591 C1-set domain containing genenames.org 8.282E-5 2.857E-3 1.574E-2 1.143E-2 5 42
5 1150 NADH:ubiquinone oxidoreductase supernumerary subunits genenames.org 2.819E-4 7.382E-3 4.066E-2 3.890E-2 4 30
6 357 ARF GTPase family genenames.org 3.210E-4 7.382E-3 4.066E-2 4.429E-2 4 31
7 735 Secretory carrier membrane proteins genenames.org 1.119E-3 2.143E-2
1.180E-1
1.544E-1
 2 5
8 588 Histocompatibility complex|C1-set domain containing genenames.org 1.242E-3 2.143E-2
1.180E-1
1.714E-1
 4 44
9 1028 Cytosolic iron-sulfur assembly components genenames.org 1.666E-3 2.555E-2
1.407E-1
2.300E-1
 2 6
10 362 WD repeat domain containing genenames.org 2.120E-3 2.926E-2
1.612E-1
2.926E-1
 9 262
11 778 Tubulins genenames.org 2.628E-3 3.298E-2
1.816E-1
3.627E-1
 3 26
12 950 Gelsolin/villins genenames.org 3.067E-3 3.527E-2
1.943E-1
4.232E-1
 2 8
13 1329 INO80 complex |SRCAP complex genenames.org 3.915E-3 4.156E-2
2.289E-1
5.403E-1
 2 9
14 642 Mitochondrial complex III: ubiquinol-cytochrome c reductase complex subunits genenames.org 4.860E-3 4.790E-2
2.639E-1
6.707E-1
 2 10
Show 9 more annotations

13: Coexpression [Display Chart] 6553 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M10395 Genes up-regulated in non-spontaneously immortalizing (NSI) primary breast cancer tumor cultures upon expression of TERT [GeneID=7015] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.942E-20 2.583E-16 2.419E-15 2.583E-16 39 377
2 M11171 Genes up-regulated in fibroblasts expressing mutant forms of ERCC3 [GeneID=2071] after UV irradiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.328E-17 4.352E-14 4.076E-13 8.705E-14 33 309
3 M2113 Genes whose expression in brain significantly and negatively correlated with the duration of all psychiatric disorders studied. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.133E-16 3.215E-13 3.011E-12 1.398E-12 23 145
4 M2188 Genes encoding mRNA transcripts specifically bound by DCP2 [GeneID=167227]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.902E-16 3.215E-13 3.011E-12 1.902E-12 19 89
5 M5936 Genes encoding proteins involved in oxidative phosphorylation. MSigDB H: Hallmark Gene Sets (v5.1) 3.434E-16 3.215E-13 3.011E-12 2.250E-12 26 200
6 M5797 Genes up-regulated in peripheral blood mononuclear cells (PBMC) from patients with type 1 diabetes at the time of diagnosis versus those with type 2 diabetes at the time of diagnosis. MSigDB C7: Immunologic Signatures (v5.1) 3.434E-16 3.215E-13 3.011E-12 2.250E-12 26 200
7 M5783 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with type 1 diabetes at the time of the diagnosis versus those at 1 month later. MSigDB C7: Immunologic Signatures (v5.1) 3.434E-16 3.215E-13 3.011E-12 2.250E-12 26 200
8 M9788 Genes up-regulated in differentiating C2C12 cells (myoblasts) upon expression of PPARGC1A [GeneID=10891] off an adenoviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.076E-15 2.288E-12 2.142E-11 2.016E-11 35 420
9 M5787 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with type 1 diabetes at the time of the diagnosis versus those at 4 months later. MSigDB C7: Immunologic Signatures (v5.1) 3.286E-15 2.288E-12 2.142E-11 2.153E-11 25 200
10 M9577 Mitochondrial genes MSigDB C2: CGP Curated Gene Sets (v5.1) 3.491E-15 2.288E-12 2.142E-11 2.288E-11 36 447
11 GSE42021 CD24HI TREG VS CD24HI TCONV THYMUS UP Genes up-regulated in CD42 high [GeneID=100133941] cells from thymus: T reg versus T conv. MSigDB C7: Immunologic Signatures (v5.1) 2.998E-14 1.786E-11 1.673E-10 1.965E-10 24 200
12 M9433 Mitochondrial genes; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.909E-13 1.042E-10 9.761E-10 1.251E-9 33 429
13 M863 Myb-regulated genes in MCF7 (breast cancer) and lung epithelial cell lines overexpressing MYBL2, MYBL1 or MYB [GeneID=4605;4603;4602]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.317E-13 2.680E-10 2.510E-9 3.484E-9 28 318
14 M2336 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 17. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.441E-12 1.143E-9 1.070E-8 1.600E-8 21 181
15 M18491 Genes up-regulated by ESRRA [GeneID=2101] only. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.192E-11 5.208E-9 4.877E-8 7.812E-8 29 388
16 GSE26030 TH1 VS TH17 RESTIMULATED DAY15 POST POLARIZATION DN Genes down-regulated in T helper cells 15 days post polarization and stimulated with anti-CD3 and anti-CD28: Th1 versus Th17. MSigDB C7: Immunologic Signatures (v5.1) 1.532E-11 5.816E-9 5.447E-8 1.004E-7 21 199
17 GSE43260 BTLA POS VS NEG INTRATUMORAL CD8 TCELL UP Genes up-regulated in tumor-infiltrating CD8 T cells: BTLA+ [GeneID=151888] versus BTLA- [GeneID=151888]. MSigDB C7: Immunologic Signatures (v5.1) 1.686E-11 5.816E-9 5.447E-8 1.105E-7 21 200
18 GSE41176 WT VS TAK1 KO ANTI IGM STIM BCELL 24H UP Genes up-regulated in B lymphocytes treated by anti IgM for 24h: wildtype versus MAP3K7 [GeneID=6885] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.686E-11 5.816E-9 5.447E-8 1.105E-7 21 200
19 GSE42021 CD24LO TREG VS CD24LO TCONV THYMUS DN Genes down-regulated in CD42 low [GeneID=100133941] cells from thymus: T reg versus T conv. MSigDB C7: Immunologic Signatures (v5.1) 1.686E-11 5.816E-9 5.447E-8 1.105E-7 21 200
20 M9565 Up-regulated genes whose expression correlates with copy number gains in pancreatic adenocarcinoma cell lines and primary tumor specimens. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.409E-11 7.894E-9 7.392E-8 1.579E-7 25 296
21 M5322 Genes down-regulated in comparison of memory CD4 [GeneID=920] T cells from young donors treated with TSST at 40 h versus those from old donors treated with TSST at 40 h. MSigDB C7: Immunologic Signatures (v5.1) 1.144E-10 3.281E-8 3.073E-7 7.493E-7 20 199
22 GSE27434 WT VS DNMT1 KO TREG UP Genes up-regulated in T reg: wildtype versus DNMT1 [GeneID=1786] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.252E-10 3.281E-8 3.073E-7 8.203E-7 20 200
23 GSE42021 CD24INT TREG VS CD24INT TCONV THYMUS UP Genes up-regulated in CD42 int [GeneID=100133941] cells from thymus: T reg versus T conv. MSigDB C7: Immunologic Signatures (v5.1) 1.252E-10 3.281E-8 3.073E-7 8.203E-7 20 200
24 M5781 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from healthy donors versus PBMCs from patients with type 2 diabetes at the time of diagnosis. MSigDB C7: Immunologic Signatures (v5.1) 1.252E-10 3.281E-8 3.073E-7 8.203E-7 20 200
25 M2720 Genes up-regulated in primary thyrocyte cultures in response to cAMP signaling pathway activation by thyrotropin (TSH). MSigDB C6: Oncogenic Signatures (v5.1) 1.252E-10 3.281E-8 3.073E-7 8.203E-7 20 200
26 M15801 Cluster 2: genes up-regulated in B493-6 cells (B lymphocytes) by serum alone or in combination with MYC [GeneID=4609] but not by MYC alone. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.682E-10 6.760E-8 6.331E-7 1.758E-6 15 108
27 M13936 Genes down-regulated in BJAB cells (B-lymphoma) after glutamine [PubChem=738] deprivation. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.824E-10 9.280E-8 8.691E-7 2.506E-6 25 337
28 GSE20727 CTRL VS ROS INHIBITOR TREATED DC UP Genes up-regulated in dendritic cells: untreated versus diphenyleneiodonium (DPI) [PubChem=2733504]. MSigDB C7: Immunologic Signatures (v5.1) 5.712E-10 1.296E-7 1.214E-6 3.743E-6 19 195
29 M905 Genes down-regulated in C666-1 cells (nasopharyngeal carcinoma) by stable expression of RASSF1 [GeneID=11186]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.736E-10 1.296E-7 1.214E-6 3.759E-6 9 29
30 GSE42724 NAIVE VS B1 BCELL DN Genes down-regulated in B lymphocytes: naïve versus B1. MSigDB C7: Immunologic Signatures (v5.1) 7.406E-10 1.514E-7 1.418E-6 4.853E-6 19 198
31 M3192 Genes up-regulated in comparison of IgD- peripheral blood B cells versus dark zone germinal center B cells. MSigDB C7: Immunologic Signatures (v5.1) 8.067E-10 1.514E-7 1.418E-6 5.286E-6 19 199
32 M3604 Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 48 h after stimulation with antigen-B7-1. MSigDB C7: Immunologic Signatures (v5.1) 8.782E-10 1.514E-7 1.418E-6 5.755E-6 19 200
33 GSE16450 IMMATURE VS MATURE NEURON CELL LINE DN Genes down-regulated in the neuron cell line: immature versus mature. MSigDB C7: Immunologic Signatures (v5.1) 8.782E-10 1.514E-7 1.418E-6 5.755E-6 19 200
34 M4589 Genes down-regulated in comparison of naive T cells at day 0 versus CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 5. MSigDB C7: Immunologic Signatures (v5.1) 8.782E-10 1.514E-7 1.418E-6 5.755E-6 19 200
35 GSE24210 CTRL VS IL35 TREATED TCONV CD4 TCELL DN Genes down-regulated in T conv cells: control versus treated with IL35. MSigDB C7: Immunologic Signatures (v5.1) 8.782E-10 1.514E-7 1.418E-6 5.755E-6 19 200
36 M5833 Genes up-regulated in comparison of effector CD8 T cells versus exhausted CD8 T cells. MSigDB C7: Immunologic Signatures (v5.1) 8.782E-10 1.514E-7 1.418E-6 5.755E-6 19 200
37 M4074 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus those stimulated at 8 h. MSigDB C7: Immunologic Signatures (v5.1) 8.782E-10 1.514E-7 1.418E-6 5.755E-6 19 200
38 M4463 Genes down-regulated in comparison of monocytes cultured for 1 day versus those cultured for 7 days. MSigDB C7: Immunologic Signatures (v5.1) 8.782E-10 1.514E-7 1.418E-6 5.755E-6 19 200
39 M11197 Housekeeping genes identified as expressed across 19 normal tissues. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.576E-9 2.648E-7 2.480E-6 1.033E-5 26 389
40 M15377 Genes in the AKT1 [GeneID=207] pathway which depend on MTOR [GeneID=2475], sensitive to RAD001 (everolimus) [PubChem=6442177]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.889E-9 3.095E-7 2.898E-6 1.238E-5 8 23
41 M15112 Genes that comprise the mitochondria gene module MSigDB C2: CGP Curated Gene Sets (v5.1) 3.452E-9 5.517E-7 5.167E-6 2.262E-5 19 217
42 M18854 Genes down-regulated in BJUB cells (B-lymphoma) in response to rapamycin [PubChem=6610346] treatment. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.472E-9 6.977E-7 6.534E-6 2.930E-5 20 245
43 M4443 Genes down-regulated in comparison of naive B cells versus plasma cells from bone marrow and blood. MSigDB C7: Immunologic Signatures (v5.1) 4.954E-9 7.321E-7 6.856E-6 3.246E-5 18 198
44 M12139 Genes down-regulated in acute promyelocytic leukemia (APL) patients with mutated FLT3 [GeneID=2322]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.023E-9 7.321E-7 6.856E-6 3.291E-5 7 17
45 M3246 Genes down-regulated in comparison of naive B cells versus memory B cells. MSigDB C7: Immunologic Signatures (v5.1) 5.366E-9 7.321E-7 6.856E-6 3.516E-5 18 199
46 M5157 Genes up-regulated in comparison of macrophages versus macrophages exposed to L.donovani. MSigDB C7: Immunologic Signatures (v5.1) 5.810E-9 7.321E-7 6.856E-6 3.807E-5 18 200
47 M5188 Genes down-regulated in comparison of dendritic cells (DC) exposed to 5 worm/well B. malayi versus macrophages exposed to 5 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v5.1) 5.810E-9 7.321E-7 6.856E-6 3.807E-5 18 200
48 GSE41867 DAY6 VS DAY8 LCMV ARMSTRONG EFFECTOR CD8 TCELL DN Genes down-regulated in CD8 T effector cells, acute infection with LCMV-Armstrong: day 6 versus day 8. MSigDB C7: Immunologic Signatures (v5.1) 5.810E-9 7.321E-7 6.856E-6 3.807E-5 18 200
49 M4168 Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 12 h. MSigDB C7: Immunologic Signatures (v5.1) 5.810E-9 7.321E-7 6.856E-6 3.807E-5 18 200
50 GSE40274 CTRL VS FOXP3 AND HELIOS TRANSDUCED ACTIVATED CD4 TCELL DN Genes down-regulated in CD4 T conv: control versus over-expression of IKZF2 and FOXP3 [GeneID=22807;50943]. MSigDB C7: Immunologic Signatures (v5.1) 5.810E-9 7.321E-7 6.856E-6 3.807E-5 18 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2084 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 54SK Top 500 All 54SK Top 500 All Brain Map - Allen iN 6.098E-34 1.271E-30 1.044E-29 1.271E-30 60 488
2 54SK Top 500 Cluster 4 54SK Top 500 Cluster 4 Brain Map - Allen iN 3.686E-32 3.840E-29 3.157E-28 7.681E-29 36 141
3 54Dn SubClass 54Dn 2 Top 500 All 54Dn SubClass 54Dn 2 Top 500 All Brain Map - Allen iN 5.921E-21 4.113E-18 3.381E-17 1.234E-17 46 495
4 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 k1 1000 dev lower uro neuro e14.5 PelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.112E-20 5.794E-18 4.762E-17 2.318E-17 37 310
5 26Dn SubClass 26Dn 2 Top 500 All 26Dn SubClass 26Dn 2 Top 500 All Brain Map - Allen iN 1.982E-18 8.260E-16 6.790E-15 4.130E-15 43 498
6 54Dn SubClass 54Dn 4 Top 500 All 54Dn SubClass 54Dn 4 Top 500 All Brain Map - Allen iN 1.875E-16 6.511E-14 5.352E-13 3.907E-13 40 487
7 54SK SubClass 54SK 1 Top 500 All 54SK SubClass 54SK 1 Top 500 All Brain Map - Allen iN 3.508E-16 1.044E-13 8.584E-13 7.310E-13 40 496
8 26Dp SubClass 26Dp 1 Top 500 Cluster 0 26Dp SubClass 26Dp 1 Top 500 Cluster 0 Brain Map - Allen iN 7.652E-16 1.993E-13 1.638E-12 1.595E-12 19 90
9 Facebase RNAseq ratio e10.5 MandibularArch vs MaxillaryArch 1000 K2 FacebaseRNAseq ratio e10.5 MandibularArch vs MaxillaryArch top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 2.681E-15 6.209E-13 5.103E-12 5.588E-12 34 378
10 54SK SubClass 54SK 1 Top 500 Cluster 3 54SK SubClass 54SK 1 Top 500 Cluster 3 Brain Map - Allen iN 5.489E-14 1.144E-11 9.402E-11 1.144E-10 17 84
11 Facebase RNAseq ratio e10.5 MandibularArch vs MaxillaryArch 500 K2 FacebaseRNAseq ratio e10.5 MandibularArch vs MaxillaryArch top-relative-expression-ranked 500 k-means-cluster#2 FaceBase_RNAseq 7.104E-14 1.346E-11 1.106E-10 1.481E-10 23 181
12 54SK SubClass 54SK 2 Top 500 Cluster 2 54SK SubClass 54SK 2 Top 500 Cluster 2 Brain Map - Allen iN 1.507E-13 2.617E-11 2.151E-10 3.141E-10 17 89
13 54Dn SubClass 54Dn 2 Top 500 Cluster 4 54Dn SubClass 54Dn 2 Top 500 Cluster 4 Brain Map - Allen iN 1.829E-13 2.933E-11 2.411E-10 3.813E-10 17 90
14 54Dp SubClass 54Dp 2 Top 500 All 54Dp SubClass 54Dp 2 Top 500 All Brain Map - Allen iN 2.202E-13 3.277E-11 2.694E-10 4.588E-10 36 492
15 26Dp SubClass 26Dp 2 Top 500 All 26Dp SubClass 26Dp 2 Top 500 All Brain Map - Allen iN 2.802E-13 3.893E-11 3.200E-10 5.839E-10 36 496
16 Facebase RNAseq ratio e10.5 MandibularArch vs MaxillaryArch 500 FacebaseRNAseq ratio e10.5 MandibularArch vs MaxillaryArch top-relative-expression-ranked 500 FaceBase_RNAseq 1.029E-12 1.341E-10 1.102E-9 2.145E-9 35 491
17 26Dn SubClass 26Dn 2 Top 500 Cluster 4 26Dn SubClass 26Dn 2 Top 500 Cluster 4 Brain Map - Allen iN 1.414E-12 1.637E-10 1.346E-9 2.947E-9 18 117
18 54Dp SubClass 54Dp 2 Top 500 Cluster 3 54Dp SubClass 54Dp 2 Top 500 Cluster 3 Brain Map - Allen iN 1.414E-12 1.637E-10 1.346E-9 2.947E-9 18 117
19 54Dp SubClass 54Dp 1 Top 500 Cluster 1 54Dp SubClass 54Dp 1 Top 500 Cluster 1 Brain Map - Allen iN 1.664E-12 1.825E-10 1.500E-9 3.468E-9 15 74
20 26Dp SubClass 26Dp 2 Top 500 Cluster 1 26Dp SubClass 26Dp 2 Top 500 Cluster 1 Brain Map - Allen iN 2.554E-12 2.662E-10 2.188E-9 5.323E-9 18 121
21 26Dp SubClass 26Dp 1 Top 500 All 26Dp SubClass 26Dp 1 Top 500 All Brain Map - Allen iN 4.946E-12 4.909E-10 4.035E-9 1.031E-8 34 491
22 54Dn SubClass 54Dn 2 Top 500 Cluster 0 54Dn SubClass 54Dn 2 Top 500 Cluster 0 Brain Map - Allen iN 8.904E-12 8.434E-10 6.933E-9 1.856E-8 18 130
23 54SK SubClass 54SK 3 Top 500 Cluster 1 54SK SubClass 54SK 3 Top 500 Cluster 1 Brain Map - Allen iN 1.004E-11 9.096E-10 7.476E-9 2.092E-8 17 114
24 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 k3 1000 dev lower uro neuro e14.5 PelvicGanglion Sox10 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 6.687E-11 5.806E-9 4.772E-8 1.394E-7 17 128
25 54SK SubClass 54SK 2 Top 500 All 54SK SubClass 54SK 2 Top 500 All Brain Map - Allen iN 7.944E-11 6.622E-9 5.443E-8 1.656E-7 32 486
26 Facebase RNAseq ratio e9.5 MaxillaryArch vs Mandibular 2500 K4 FacebaseRNAseq ratio e9.5 MaxillaryArch vs Mandibular top-relative-expression-ranked 2500 k-means-cluster#4 FaceBase_RNAseq 1.117E-10 8.951E-9 7.357E-8 2.327E-7 24 281
27 54Dp SubClass 54Dp 1 Top 500 All 54Dp SubClass 54Dp 1 Top 500 All Brain Map - Allen iN 4.936E-10 3.810E-8 3.132E-7 1.029E-6 31 493
28 gudmap developingGonad e18.5 testes 1000 k3 DevelopingGonad e18.5 testes emap-11164 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 8.110E-10 6.036E-8 4.961E-7 1.690E-6 26 362
29 Lungmap Mouse e14.5 Epithelial (GSE52583) Top 500 All Mouse Lung E14.5 Epithelial top 500 Lungmap Mouse Single Cell (Lungmap.net) 8.512E-10 6.117E-8 5.028E-7 1.774E-6 29 446
30 54SK SubClass 54SK 3 Top 500 All 54SK SubClass 54SK 3 Top 500 All Brain Map - Allen iN 1.211E-9 8.414E-8 6.916E-7 2.524E-6 30 482
31 gudmap developingGonad e14.5 testes 1000 k5 DevelopingGonad e14.5 testes emap-6710 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.547E-9 1.040E-7 8.547E-7 3.224E-6 28 429
32 26Dn SubClass 26Dn 1 Top 500 All 26Dn SubClass 26Dn 1 Top 500 All Brain Map - Allen iN 1.698E-9 1.106E-7 9.090E-7 3.539E-6 30 489
33 gudmap developingGonad P2 testes 1000 k2 DevelopingGonad P2 testes emap-30171 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.829E-9 1.148E-7 9.437E-7 3.811E-6 25 349
34 26Dn SubClass 26Dn 2 Top 500 Cluster 3 26Dn SubClass 26Dn 2 Top 500 Cluster 3 Brain Map - Allen iN 1.873E-9 1.148E-7 9.437E-7 3.903E-6 12 69
35 gudmap developingGonad e16.5 testes 1000 k3 DevelopingGonad e16.5 testes emap-8444 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.028E-9 1.208E-7 9.925E-7 4.226E-6 26 378
36 26Dn SubClass 26Dn 1 Top 500 Cluster 1 26Dn SubClass 26Dn 1 Top 500 Cluster 1 Brain Map - Allen iN 2.638E-9 1.527E-7 1.255E-6 5.498E-6 12 71
37 80Dp SubClass 80Dp 1 Top 500 Cluster 0 80Dp SubClass 80Dp 1 Top 500 Cluster 0 Brain Map - Allen iN 4.319E-9 2.433E-7 2.000E-6 9.001E-6 12 74
38 54Dn SubClass 54Dn 4 Top 500 Cluster 2 54Dn SubClass 54Dn 4 Top 500 Cluster 2 Brain Map - Allen iN 1.162E-8 6.375E-7 5.240E-6 2.423E-5 14 116
39 Facebase RNAseq ratio e9.5 MaxillaryArch vs Mandibular 500 K1 FacebaseRNAseq ratio e9.5 MaxillaryArch vs Mandibular top-relative-expression-ranked 500 k-means-cluster#1 FaceBase_RNAseq 1.300E-8 6.948E-7 5.711E-6 2.710E-5 14 117
40 54Dp SubClass 54Dp 1 Top 500 Cluster 2 54Dp SubClass 54Dp 1 Top 500 Cluster 2 Brain Map - Allen iN 1.985E-8 1.034E-6 8.502E-6 4.137E-5 15 141
41 80Dn SubClass 80Dn 1 Top 500 Cluster 0 80Dn SubClass 80Dn 1 Top 500 Cluster 0 Brain Map - Allen iN 2.672E-8 1.326E-6 1.090E-5 5.569E-5 28 489
42 80Dn SubClass 80Dn 1 Top 500 All 80Dn SubClass 80Dn 1 Top 500 All Brain Map - Allen iN 2.672E-8 1.326E-6 1.090E-5 5.569E-5 28 489
43 54Dn SubClass 54Dn 4 Top 500 Cluster 3 54Dn SubClass 54Dn 4 Top 500 Cluster 3 Brain Map - Allen iN 7.708E-8 3.736E-6 3.070E-5 1.606E-4 10 61
44 54Dn SubClass 54Dn 1 Top 500 Cluster 0 54Dn SubClass 54Dn 1 Top 500 Cluster 0 Brain Map - Allen iN 1.086E-7 5.028E-6 4.133E-5 2.263E-4 27 491
45 54Dn SubClass 54Dn 1 Top 500 All 54Dn SubClass 54Dn 1 Top 500 All Brain Map - Allen iN 1.086E-7 5.028E-6 4.133E-5 2.263E-4 27 491
46 54SK Top 500 Cluster 0 54SK Top 500 Cluster 0 Brain Map - Allen iN 1.258E-7 5.699E-6 4.684E-5 2.621E-4 16 185
47 80Dn Top 500 Cluster 4 80Dn Top 500 Cluster 4 Brain Map - Allen iN 2.656E-7 1.178E-5 9.680E-5 5.535E-4 12 106
48 Lungmap Mouse e16.5 Matrix fibroblast SubClass Intermediate Fibroblast Top 500 All Mouse Lung E16.5 Intermediate Fibroblast top 500 Lungmap Mouse Single Cell (Lungmap.net) 2.815E-7 1.222E-5 1.005E-4 5.867E-4 24 420
49 gudmap developingGonad e11.5 testes 500 DevelopingGonad e11.5 testes emap-3226 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.756E-7 2.426E-5 1.994E-4 1.200E-3 24 437
50 GSM791119 500 Stem Cells, SC.GMP.BM, Lineage- sca1- ckithi CD34+ FcgRhi, Bone marrow, avg-3 Immgen.org, GSE15907 5.820E-7 2.426E-5 1.994E-4 1.213E-3 23 406
Show 45 more annotations

15: Computational [Display Chart] 531 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MORF AP2M1 Neighborhood of AP2M1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 9.554E-17 3.164E-14 2.169E-13 5.073E-14 33 203
2 MORF CSNK2B Neighborhood of CSNK2B MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.192E-16 3.164E-14 2.169E-13 6.329E-14 37 261
3 MORF SOD1 Neighborhood of SOD1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.694E-13 8.308E-11 5.693E-10 2.492E-10 32 254
4 MORF MAP2K2 Neighborhood of MAP2K2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.693E-12 4.177E-10 2.863E-9 1.961E-9 22 126
5 MORF GPX4 Neighborhood of GPX4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.933E-12 4.177E-10 2.863E-9 2.089E-9 15 51
6 MORF RAN Neighborhood of RAN MSigDb: C4 - CGN: Cancer Gene Neighborhood 7.671E-12 6.789E-10 4.652E-9 4.073E-9 30 248
7 MORF PSMC1 Neighborhood of PSMC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.587E-10 1.204E-8 8.248E-8 8.425E-8 23 166
8 MORF FBL Neighborhood of FBL MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.897E-10 1.259E-8 8.629E-8 1.007E-7 20 125
9 module 151 Genes in module 151 MSigDb: C4 - CM: Cancer Modules 3.899E-10 2.168E-8 1.486E-7 2.070E-7 31 308
10 module 114 Genes in module 114 MSigDb: C4 - CM: Cancer Modules 4.082E-10 2.168E-8 1.486E-7 2.168E-7 32 327
11 MORF EIF3S2 Neighborhood of EIF3S2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.230E-10 2.525E-8 1.730E-7 2.777E-7 26 224
12 MORF PPP1CA Neighborhood of PPP1CA MSigDb: C4 - CGN: Cancer Gene Neighborhood 7.464E-10 3.303E-8 2.264E-7 3.964E-7 21 149
13 MORF RAD23A Neighborhood of RAD23A MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.180E-9 1.707E-7 1.170E-6 2.219E-6 30 320
14 MORF SKP1A Neighborhood of SKP1A MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.383E-8 8.435E-7 5.780E-6 1.265E-5 21 180
15 module 93 Genes in module 93 MSigDb: C4 - CM: Cancer Modules 2.383E-8 8.435E-7 5.780E-6 1.265E-5 21 180
16 MORF G22P1 Neighborhood of G22P1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.662E-8 8.834E-7 6.054E-6 1.413E-5 19 149
17 MORF CTBP1 Neighborhood of CTBP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.698E-8 1.155E-6 7.915E-6 1.964E-5 19 152
18 MORF DDB1 Neighborhood of DDB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.169E-8 1.820E-6 1.247E-5 3.276E-5 23 225
19 MORF DAP3 Neighborhood of DAP3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.076E-7 3.008E-6 2.061E-5 5.715E-5 20 179
20 MORF AATF Neighborhood of AATF MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.419E-7 3.768E-6 2.582E-5 7.536E-5 20 182
21 MORF RAC1 Neighborhood of RAC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.501E-7 3.796E-6 2.601E-5 7.971E-5 21 200
22 MORF PRKAG1 Neighborhood of PRKAG1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.288E-7 5.523E-6 3.785E-5 1.215E-4 21 205
23 module 152 Genes in module 152 MSigDb: C4 - CM: Cancer Modules 2.615E-7 6.037E-6 4.137E-5 1.388E-4 16 123
24 MORF HDAC1 Neighborhood of HDAC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.866E-7 6.341E-6 4.346E-5 1.522E-4 22 226
25 MORF RAB1A Neighborhood of RAB1A MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.023E-7 1.245E-5 8.533E-5 3.198E-4 19 181
26 module 77 Genes in module 77 MSigDb: C4 - CM: Cancer Modules 6.097E-7 1.245E-5 8.533E-5 3.238E-4 8 28
27 MORF GMPS Neighborhood of GMPS MSigDb: C4 - CGN: Cancer Gene Neighborhood 7.259E-7 1.428E-5 9.783E-5 3.854E-4 10 49
28 MORF EI24 Neighborhood of EI24 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.274E-6 2.415E-5 1.655E-4 6.763E-4 16 138
29 MORF XRCC5 Neighborhood of XRCC5 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.929E-6 3.532E-5 2.421E-4 1.024E-3 20 214
30 MORF ANP32B Neighborhood of ANP32B MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.072E-6 3.668E-5 2.513E-4 1.100E-3 18 178
31 MORF BUB3 Neighborhood of BUB3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.092E-6 5.204E-5 3.566E-4 1.642E-3 22 260
32 module 350 Genes in module 350 MSigDb: C4 - CM: Cancer Modules 3.136E-6 5.204E-5 3.566E-4 1.665E-3 10 57
33 MORF GNB1 Neighborhood of GNB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.425E-6 5.511E-5 3.777E-4 1.819E-3 23 282
34 MORF DAP Neighborhood of DAP MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.134E-6 6.456E-5 4.424E-4 2.195E-3 11 72
35 module 149 Genes in module 149 MSigDb: C4 - CM: Cancer Modules 4.895E-6 7.398E-5 5.070E-4 2.599E-3 8 36
36 module 62 Genes in module 62 MSigDb: C4 - CM: Cancer Modules 5.136E-6 7.398E-5 5.070E-4 2.727E-3 12 88
37 MORF PRKAR1A Neighborhood of PRKAR1A MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.155E-6 7.398E-5 5.070E-4 2.737E-3 15 136
38 MORF ERH Neighborhood of ERH MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.894E-6 9.633E-5 6.602E-4 3.661E-3 13 106
39 module 81 Genes in module 81 MSigDb: C4 - CM: Cancer Modules 1.209E-5 1.646E-4 1.128E-3 6.421E-3 6 20
40 MORF UBE2I Neighborhood of UBE2I MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.550E-5 3.385E-4 2.320E-3 1.354E-2 18 213
41 MORF ATOX1 Neighborhood of ATOX1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.053E-5 3.954E-4 2.710E-3 1.621E-2 10 73
42 MORF PPP2R4 Neighborhood of PPP2R4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.318E-5 4.196E-4 2.875E-3 1.762E-2 8 46
43 module 144 Genes in module 144 MSigDb: C4 - CM: Cancer Modules 3.726E-5 4.601E-4 3.153E-3 1.978E-2 4 8
44 module 83 Genes in module 83 MSigDb: C4 - CM: Cancer Modules 4.280E-5 5.166E-4 3.540E-3 2.273E-2 22 307
45 MORF USP5 Neighborhood of USP5 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.574E-5 5.397E-4 3.699E-3 2.429E-2 8 48
46 module 42 Genes in module 42 MSigDb: C4 - CM: Cancer Modules 4.916E-5 5.674E-4 3.889E-3 2.610E-2 6 25
47 MORF PHB Neighborhood of PHB MSigDb: C4 - CGN: Cancer Gene Neighborhood 7.282E-5 8.152E-4 5.587E-3 3.867E-2 12 114
48 module 43 Genes in module 43 MSigDb: C4 - CM: Cancer Modules 7.369E-5 8.152E-4 5.587E-3 3.913E-2 11 97
49 module 159 Genes in module 159 MSigDb: C4 - CM: Cancer Modules 7.595E-5 8.230E-4 5.640E-3 4.033E-2 10 81
50 module 115 Genes in module 115 MSigDb: C4 - CM: Cancer Modules 7.841E-5 8.328E-4 5.707E-3 4.164E-2 6 27
Show 45 more annotations

16: MicroRNA [Display Chart] 1114 annotations before applied cutoff / 19844 genes in category

No results to display

17: Drug [Display Chart] 25460 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6920 DN AG-012559 [369370-06-9]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 5.337E-19 1.359E-14 1.457E-13 1.359E-14 28 189
2 6919 DN scriptaid; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 9.131E-18 6.976E-14 7.480E-13 2.325E-13 27 192
3 6906 DN STOCK1N-28457; Down 200; 20uM; MCF7; HT HG-U133A Broad Institute CMAP 1.370E-17 6.976E-14 7.480E-13 3.488E-13 27 195
4 5327 DN Benfluorex hydrochloride [23642-66-2]; Down 200; 10.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.370E-17 6.976E-14 7.480E-13 3.488E-13 27 195
5 2000 DN Tolazoline hydrochloride [59-97-2]; Down 200; 20.4uM; HL60; HG-U133A Broad Institute CMAP 1.370E-17 6.976E-14 7.480E-13 3.488E-13 27 195
6 6912 DN PF-00562151-00 [351320-12-2]; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 7.457E-17 3.164E-13 3.393E-12 1.898E-12 26 190
7 6918 DN ICI182,780; Down 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 1.257E-16 4.570E-13 4.900E-12 3.199E-12 26 194
8 6905 DN Orlistat; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.623E-16 5.166E-13 5.539E-12 4.133E-12 26 196
9 6719 DN Ambroxol hydrochloride [23828-92-4]; Down 200; 9.6uM; PC3; HT HG-U133A Broad Institute CMAP 7.482E-15 2.117E-11 2.269E-10 1.905E-10 24 190
10 1419 DN Oxolinic acid [14698-29-4]; Down 200; 15.4uM; HL60; HG-U133A Broad Institute CMAP 9.497E-15 2.418E-11 2.593E-10 2.418E-10 24 192
11 1413 DN Pyrantel tartrate [33401-94-4]; Down 200; 11.2uM; HL60; HG-U133A Broad Institute CMAP 7.636E-13 1.767E-9 1.895E-8 1.944E-8 22 192
12 6909 DN SB 202190; Down 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.291E-12 2.739E-9 2.937E-8 3.287E-8 22 197
13 6916 DN trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP 2.768E-12 5.422E-9 5.813E-8 7.048E-8 21 184
14 1424 DN Hyoscyamine (L) [101-31-5]; Down 200; 13.8uM; HL60; HG-U133A Broad Institute CMAP 7.738E-12 1.313E-8 1.408E-7 1.970E-7 21 194
15 2042 DN Chlortetracycline hydrochloride [64-72-2]; Down 200; 7.8uM; HL60; HG-U133A Broad Institute CMAP 7.738E-12 1.313E-8 1.408E-7 1.970E-7 21 194
16 7085 UP GW8510; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 8.545E-12 1.360E-8 1.458E-7 2.176E-7 21 195
17 1373 DN Clindamycin hydrochloride [21462-39-5]; Down 200; 8.6uM; HL60; HG-U133A Broad Institute CMAP 9.431E-12 1.412E-8 1.514E-7 2.401E-7 21 196
18 6709 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 4.107E-11 5.809E-8 6.228E-7 1.046E-6 20 190
19 6720 DN Paclitaxel [33069-62-4]; Down 200; 4.6uM; PC3; HT HG-U133A Broad Institute CMAP 4.520E-11 6.057E-8 6.494E-7 1.151E-6 20 191
20 1770 DN Lobeline alpha (-) hydrochoride [134-63-4]; Down 200; 10.6uM; HL60; HG-U133A Broad Institute CMAP 7.236E-11 9.212E-8 9.877E-7 1.842E-6 20 196
21 D006997 Hypochlorous Acid CTD 1.227E-10 1.487E-7 1.594E-6 3.123E-6 27 376
22 6914 DN carmustine; Down 200; 100uM; MCF7; HT HG-U133A Broad Institute CMAP 4.404E-10 4.875E-7 5.227E-6 1.121E-5 19 194
23 1884 DN Cimetidine [51481-61-9]; Down 200; 15.8uM; PC3; HG-U133A Broad Institute CMAP 4.404E-10 4.875E-7 5.227E-6 1.121E-5 19 194
24 4809 DN Carcinine [56897-53-1]; Down 200; 22uM; MCF7; HT HG-U133A Broad Institute CMAP 6.237E-10 6.617E-7 7.095E-6 1.588E-5 19 198
25 1959 UP Paclitaxel [33069-62-4]; Up 200; 4.6uM; PC3; HG-U133A Broad Institute CMAP 6.795E-10 6.920E-7 7.420E-6 1.730E-5 19 199
26 CID000448381 2hqu Stitch 7.256E-10 7.105E-7 7.618E-6 1.847E-5 21 247
27 6711 DN Puromycin dihydrochloride [58-58-2]; Down 200; 7.4uM; PC3; HT HG-U133A Broad Institute CMAP 1.419E-9 1.338E-6 1.434E-5 3.612E-5 18 185
28 C568376 MT19c compound CTD 3.436E-9 3.125E-6 3.350E-5 8.749E-5 29 499
29 1402 DN Ampyrone [83-07-8]; Down 200; 19.6uM; HL60; HG-U133A Broad Institute CMAP 3.890E-9 3.300E-6 3.538E-5 9.904E-5 18 197
30 1926 UP Glipizide [29094-61-9]; Up 200; 9uM; PC3; HG-U133A Broad Institute CMAP 4.217E-9 3.300E-6 3.538E-5 1.074E-4 18 198
31 1973 DN Doxylamine succinate [562-10-7]; Down 200; 10.2uM; HL60; HG-U133A Broad Institute CMAP 4.217E-9 3.300E-6 3.538E-5 1.074E-4 18 198
32 1978 DN Prednisone [53-03-2]; Down 200; 11.2uM; HL60; HG-U133A Broad Institute CMAP 4.217E-9 3.300E-6 3.538E-5 1.074E-4 18 198
33 D014303 Trinitrotoluene CTD 4.278E-9 3.300E-6 3.538E-5 1.089E-4 22 299
34 CID000000854 D-ribofuranose Stitch 6.608E-9 4.949E-6 5.306E-5 1.683E-4 19 228
35 D012524 Sarin CTD 7.361E-9 5.355E-6 5.741E-5 1.874E-4 21 281
36 CID000000612 lactate Stitch 1.034E-8 7.172E-6 7.690E-5 2.633E-4 27 461
37 CID000000928 reduced diphosphopyridine nucleotide Stitch 1.042E-8 7.172E-6 7.690E-5 2.654E-4 23 342
38 1114 UP tyrphostin AG-825; Up 200; 25.2uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.450E-8 9.715E-6 1.042E-4 3.692E-4 17 190
39 1546 DN Glibenclamide [10238-21-8]; Down 200; 8uM; HL60; HG-U133A Broad Institute CMAP 1.833E-8 1.196E-5 1.283E-4 4.666E-4 17 193
40 6715 DN Amikacin hydrate [37517-28-5]; Down 200; 6.6uM; PC3; HT HG-U133A Broad Institute CMAP 1.979E-8 1.229E-5 1.318E-4 5.039E-4 17 194
41 1408 DN Pentylenetetrazole [54-95-5]; Down 200; 29uM; HL60; HG-U133A Broad Institute CMAP 1.979E-8 1.229E-5 1.318E-4 5.039E-4 17 194
42 CID000000525 malate Stitch 2.057E-8 1.247E-5 1.337E-4 5.237E-4 18 219
43 4819 DN Doxylamine succinate [562-10-7]; Down 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP 2.306E-8 1.365E-5 1.464E-4 5.870E-4 17 196
44 CID000001060 pyruvic acid Stitch 3.240E-8 1.875E-5 2.010E-4 8.249E-4 25 424
45 CID000447920 ubiquinols Stitch 4.450E-8 2.464E-5 2.642E-4 1.133E-3 12 95
46 CID000004462 ubiquinones Stitch 4.452E-8 2.464E-5 2.642E-4 1.133E-3 11 77
47 CID000123910 Kdel Sequence Stitch 5.591E-8 3.029E-5 3.247E-4 1.423E-3 10 62
48 2338 DN Mebendazole [31431-39-7]; Down 200; 13.6uM; HL60; HT HG-U133A Broad Institute CMAP 6.235E-8 3.307E-5 3.546E-4 1.587E-3 16 185
49 C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone CTD 6.993E-8 3.634E-5 3.896E-4 1.780E-3 21 320
50 CID000000703 flavin adenine dinucleotide sodium Stitch 9.784E-8 4.982E-5 5.342E-4 2.491E-3 22 356
Show 45 more annotations

18: Disease [Display Chart] 2672 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0016719 Friedreich Ataxia DisGeNET Curated 1.135E-5 1.953E-2
1.654E-1
 3.033E-2 7 44
2 umls:C0409651 Seropositive rheumatoid arthritis DisGeNET BeFree 1.622E-5 1.953E-2
1.654E-1
 4.335E-2 5 19
3 umls:C0011573 Endogenous depression DisGeNET BeFree 2.193E-5 1.953E-2
1.654E-1
5.858E-2
 3 4
4 umls:C0543698 Hypersensitive syndrome DisGeNET BeFree 4.320E-5 2.886E-2
2.444E-1
1.154E-1
 4 12
5 umls:C0027583 Nematode infections DisGeNET BeFree 5.409E-5 2.891E-2
2.448E-1
1.445E-1
 3 5