Toppgene analysis for aggregated_1964_log, IC30, positive side

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1: GO: Molecular Function [Display Chart] 614 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005201 extracellular matrix structural constituent 4.937E-8 3.031E-5 2.121E-4 3.031E-5 10 78
2 GO:0005539 glycosaminoglycan binding 1.089E-4 3.343E-2
2.340E-1
6.686E-2
 11 219
3 GO:0005518 collagen binding 2.924E-4 3.889E-2
2.721E-1
1.795E-1
 6 72
4 GO:0005520 insulin-like growth factor binding 3.959E-4 3.889E-2
2.721E-1
2.431E-1
 4 28
5 GO:0048407 platelet-derived growth factor binding 3.989E-4 3.889E-2
2.721E-1
2.449E-1
 3 12
6 GO:0031994 insulin-like growth factor I binding 3.989E-4 3.889E-2
2.721E-1
2.449E-1
 3 12
7 GO:0019838 growth factor binding 4.433E-4 3.889E-2
2.721E-1
2.722E-1
 8 142
Show 2 more annotations

2: GO: Biological Process [Display Chart] 3843 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030198 extracellular matrix organization 2.031E-17 4.230E-14 3.736E-13 7.806E-14 31 354
2 GO:0043062 extracellular structure organization 2.202E-17 4.230E-14 3.736E-13 8.460E-14 31 355
3 GO:0030335 positive regulation of cell migration 6.121E-8 6.326E-5 5.587E-4 2.352E-4 22 446
4 GO:0001763 morphogenesis of a branching structure 6.663E-8 6.326E-5 5.587E-4 2.561E-4 16 238
5 GO:2000147 positive regulation of cell motility 1.011E-7 6.326E-5 5.587E-4 3.885E-4 22 459
6 GO:0048754 branching morphogenesis of an epithelial tube 1.050E-7 6.326E-5 5.587E-4 4.034E-4 14 185
7 GO:0051272 positive regulation of cellular component movement 1.580E-7 6.326E-5 5.587E-4 6.073E-4 22 471
8 GO:0050673 epithelial cell proliferation 1.583E-7 6.326E-5 5.587E-4 6.084E-4 20 394
9 GO:0061138 morphogenesis of a branching epithelium 1.622E-7 6.326E-5 5.587E-4 6.232E-4 15 222
10 GO:0061041 regulation of wound healing 1.646E-7 6.326E-5 5.587E-4 6.326E-4 12 136
11 GO:0040017 positive regulation of locomotion 2.036E-7 7.114E-5 6.283E-4 7.826E-4 22 478
12 GO:0060485 mesenchyme development 2.899E-7 9.284E-5 8.199E-4 1.114E-3 16 265
13 GO:0071559 response to transforming growth factor beta 3.383E-7 1.000E-4 8.833E-4 1.300E-3 15 235
14 GO:0022612 gland morphogenesis 6.357E-7 1.745E-4 1.541E-3 2.443E-3 12 154
15 GO:0001655 urogenital system development 7.739E-7 1.864E-4 1.646E-3 2.974E-3 18 358
16 GO:1903034 regulation of response to wounding 7.760E-7 1.864E-4 1.646E-3 2.982E-3 21 476
17 GO:0042476 odontogenesis 8.286E-7 1.873E-4 1.654E-3 3.184E-3 11 130
18 GO:0001503 ossification 1.114E-6 2.305E-4 2.035E-3 4.281E-3 19 406
19 GO:0030324 lung development 1.139E-6 2.305E-4 2.035E-3 4.379E-3 14 225
20 GO:0030199 collagen fibril organization 1.233E-6 2.370E-4 2.093E-3 4.740E-3 7 44
21 GO:0030323 respiratory tube development 1.405E-6 2.543E-4 2.246E-3 5.399E-3 14 229
22 GO:0060562 epithelial tube morphogenesis 1.504E-6 2.543E-4 2.246E-3 5.780E-3 18 375
23 GO:0051216 cartilage development 1.522E-6 2.543E-4 2.246E-3 5.848E-3 13 198
24 GO:0048762 mesenchymal cell differentiation 1.703E-6 2.727E-4 2.408E-3 6.544E-3 13 200
25 GO:0061448 connective tissue development 1.777E-6 2.732E-4 2.413E-3 6.830E-3 15 268
26 GO:0071711 basement membrane organization 2.344E-6 3.421E-4 3.021E-3 9.009E-3 5 18
27 GO:0072001 renal system development 2.403E-6 3.421E-4 3.021E-3 9.236E-3 16 311
28 GO:0032963 collagen metabolic process 3.518E-6 4.829E-4 4.265E-3 1.352E-2 10 122
29 GO:0050768 negative regulation of neurogenesis 4.124E-6 5.465E-4 4.826E-3 1.585E-2 15 287
30 GO:0050678 regulation of epithelial cell proliferation 4.397E-6 5.632E-4 4.974E-3 1.690E-2 16 326
31 GO:0014031 mesenchymal cell development 4.635E-6 5.746E-4 5.074E-3 1.781E-2 12 186
32 GO:0044259 multicellular organismal macromolecule metabolic process 5.052E-6 6.067E-4 5.358E-3 1.942E-2 10 127
33 GO:0060541 respiratory system development 5.649E-6 6.579E-4 5.810E-3 2.171E-2 14 258
34 GO:0048864 stem cell development 6.420E-6 7.069E-4 6.243E-3 2.467E-2 12 192
35 GO:0014909 smooth muscle cell migration 6.449E-6 7.069E-4 6.243E-3 2.478E-2 8 78
36 GO:0035239 tube morphogenesis 6.622E-6 7.069E-4 6.243E-3 2.545E-2 18 417
37 GO:0007173 epidermal growth factor receptor signaling pathway 7.630E-6 7.925E-4 6.999E-3 2.932E-2 10 133
38 GO:0048863 stem cell differentiation 7.937E-6 8.027E-4 7.089E-3 3.050E-2 15 303
39 GO:0071560 cellular response to transforming growth factor beta stimulus 8.285E-6 8.164E-4 7.210E-3 3.184E-2 13 231
40 GO:0051961 negative regulation of nervous system development 1.083E-5 1.040E-3 9.187E-3 4.161E-2 15 311
41 GO:0007160 cell-matrix adhesion 1.310E-5 1.228E-3 1.085E-2
5.035E-2
 12 206
42 GO:0032102 negative regulation of response to external stimulus 1.517E-5 1.388E-3 1.226E-2
5.829E-2
 15 320
43 GO:0036293 response to decreased oxygen levels 1.632E-5 1.426E-3 1.260E-2
6.272E-2
 15 322
44 GO:0044236 multicellular organism metabolic process 1.633E-5 1.426E-3 1.260E-2
6.276E-2
 10 145
45 GO:0031589 cell-substrate adhesion 1.755E-5 1.499E-3 1.324E-2
6.744E-2
 15 324
46 GO:0014812 muscle cell migration 1.872E-5 1.564E-3 1.381E-2
7.192E-2
 8 90
47 GO:0035987 endodermal cell differentiation 2.092E-5 1.711E-3 1.511E-2
8.040E-2
 6 45
48 GO:0030574 collagen catabolic process 2.186E-5 1.725E-3 1.523E-2
8.400E-2
 7 67
49 GO:0022617 extracellular matrix disassembly 2.199E-5 1.725E-3 1.523E-2
8.451E-2
 8 92
50 GO:0007162 negative regulation of cell adhesion 2.273E-5 1.747E-3 1.543E-2
8.735E-2
 13 254
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 338 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031012 extracellular matrix 1.879E-11 6.352E-9 4.067E-8 6.352E-9 27 444
2 GO:0005578 proteinaceous extracellular matrix 3.613E-9 4.706E-7 3.012E-6 1.221E-6 22 379
3 GO:0044420 extracellular matrix component 4.177E-9 4.706E-7 3.012E-6 1.412E-6 14 143
4 GO:0005925 focal adhesion 3.494E-8 2.931E-6 1.877E-5 1.181E-5 21 393
5 GO:0005924 cell-substrate adherens junction 4.336E-8 2.931E-6 1.877E-5 1.466E-5 21 398
6 GO:0030055 cell-substrate junction 5.364E-8 3.021E-6 1.934E-5 1.813E-5 21 403
7 GO:0005604 basement membrane 1.750E-7 8.449E-6 5.409E-5 5.914E-5 11 111
8 GO:0005912 adherens junction 2.757E-7 1.165E-5 7.456E-5 9.318E-5 22 484
9 GO:0005581 collagen trimer 1.802E-6 6.766E-5 4.332E-4 6.090E-4 9 88
10 GO:0005788 endoplasmic reticulum lumen 2.636E-6 8.911E-5 5.705E-4 8.911E-4 13 207
11 GO:0098644 complex of collagen trimers 8.942E-6 2.748E-4 1.759E-3 3.022E-3 5 23
12 GO:0014069 postsynaptic density 5.691E-5 1.480E-3 9.473E-3 1.924E-2 12 238
13 GO:0099572 postsynaptic specialization 5.691E-5 1.480E-3 9.473E-3 1.924E-2 12 238
14 GO:0060076 excitatory synapse 1.226E-4 2.960E-3 1.895E-2 4.144E-2 12 258
15 GO:0005884 actin filament 2.260E-4 5.093E-3 3.260E-2
7.639E-2
 7 96
16 GO:0019898 extrinsic component of membrane 2.531E-4 5.347E-3 3.423E-2
8.556E-2
 12 279
17 GO:0071437 invadopodium 4.115E-4 8.181E-3
5.237E-2
1.391E-1
 3 12
18 GO:0008305 integrin complex 5.408E-4 9.620E-3
6.158E-2
1.828E-1
 4 30
19 GO:0098636 protein complex involved in cell adhesion 5.408E-4 9.620E-3
6.158E-2
1.828E-1
 4 30
20 GO:0070022 transforming growth factor beta receptor complex 9.517E-4 1.608E-2
1.030E-1
3.217E-1
 2 4
21 GO:0045121 membrane raft 1.551E-3 2.382E-2
1.525E-1
5.241E-1
 12 343
22 GO:0098857 membrane microdomain 1.551E-3 2.382E-2
1.525E-1
5.241E-1
 12 343
23 GO:0098794 postsynapse 2.125E-3 3.117E-2
1.996E-1
7.182E-1
 14 454
24 GO:0009897 external side of plasma membrane 2.213E-3 3.117E-2
1.996E-1
7.481E-1
 11 311
25 GO:0005587 collagen type IV trimer 2.339E-3 3.163E-2
2.025E-1
7.907E-1
 2 6
26 GO:0098642 network-forming collagen trimer 3.248E-3 4.066E-2
2.603E-1
1.000E0
 2 7
27 GO:0098645 collagen network 3.248E-3 4.066E-2
2.603E-1
1.000E0
 2 7
28 GO:0019897 extrinsic component of plasma membrane 3.369E-3 4.067E-2
2.604E-1
1.000E0
 7 152
Show 23 more annotations

4: Human Phenotype [Display Chart] 1007 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0004944 Cerebral aneurysm 3.138E-7 3.160E-4 2.367E-3 3.160E-4 5 10
2 HP:0002164 Nail dysplasia 8.721E-5 2.729E-2
2.045E-1
8.782E-2
 7 63
3 HP:0001075 Atrophic scars 1.267E-4 2.729E-2
2.045E-1
1.276E-1
 4 16
4 HP:0001056 Milia 1.267E-4 2.729E-2
2.045E-1
1.276E-1
 4 16
5 HP:0000974 Hyperextensible skin 1.355E-4 2.729E-2
2.045E-1
1.364E-1
 5 30
6 HP:0002631 Ascending aortic aneurysm 1.639E-4 2.750E-2
2.060E-1
1.650E-1
 3 7
Show 1 more annotation

5: Mouse Phenotype [Display Chart] 3467 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0003711 pathological neovascularization 6.592E-9 2.286E-5 1.995E-4 2.286E-5 14 96
2 MP:0000249 abnormal blood vessel physiology 7.011E-7 1.179E-3 1.029E-2 2.431E-3 25 410
3 MP:0009862 abnormal aorta elastic tissue morphology 1.021E-6 1.179E-3 1.029E-2 3.538E-3 7 28
4 MP:0006083 abnormal blood vessel elastic tissue morphology 1.696E-6 1.470E-3 1.283E-2 5.879E-3 7 30
5 MP:0000163 abnormal cartilage morphology 2.415E-6 1.675E-3 1.462E-2 8.373E-3 23 381
6 MP:0008438 abnormal cutaneous collagen fibril morphology 8.108E-6 4.685E-3 4.089E-2 2.811E-2 6 25
7 MP:0005595 abnormal vascular smooth muscle physiology 1.257E-5 6.228E-3
5.436E-2
 4.360E-2 13 153
8 MP:0001077 abnormal spinal nerve morphology 4.301E-5 1.737E-2
1.516E-1
1.491E-1
 11 125
9 MP:0009873 abnormal aorta tunica media morphology 4.509E-5 1.737E-2
1.516E-1
1.563E-1
 7 48
10 MP:0002932 abnormal joint morphology 5.383E-5 1.866E-2
1.629E-1
1.866E-1
 18 310
11 MP:0002651 abnormal sciatic nerve morphology 6.737E-5 2.123E-2
1.853E-1
2.336E-1
 7 51
12 MP:0000343 altered response to myocardial infarction 9.540E-5 2.390E-2
2.086E-1
3.308E-1
 9 92
13 MP:0011655 abnormal systemic artery morphology 1.026E-4 2.390E-2
2.086E-1
3.557E-1
 16 268
14 MP:0005048 abnormal thrombosis 1.065E-4 2.390E-2
2.086E-1
3.692E-1
 10 115
15 MP:0003115 abnormal respiratory system development 1.092E-4 2.390E-2
2.086E-1
3.785E-1
 13 188
16 MP:0003279 aneurysm 1.103E-4 2.390E-2
2.086E-1
3.824E-1
 7 55
17 MP:0001176 abnormal lung development 1.250E-4 2.549E-2
2.225E-1
4.334E-1
 12 165
18 MP:0009866 abnormal aorta wall morphology 1.732E-4 3.180E-2
2.776E-1
6.006E-1
 7 59
19 MP:0003641 small lung 1.743E-4 3.180E-2
2.776E-1
6.042E-1
 10 122
20 MP:0005241 abnormal retinal ganglion layer morphology 1.993E-4 3.251E-2
2.837E-1
6.909E-1
 10 124
21 MP:0000074 abnormal neurocranium morphology 1.996E-4 3.251E-2
2.837E-1
6.921E-1
 15 255
22 MP:0008852 retinal neovascularization 2.063E-4 3.251E-2
2.837E-1
7.152E-1
 6 43
23 MP:0010639 altered tumor pathology 2.263E-4 3.411E-2
2.977E-1
7.845E-1
 16 287
24 MP:0003211 abnormal aorta elastic fiber morphology 2.434E-4 3.517E-2
3.069E-1
8.440E-1
 4 16
25 MP:0009917 abnormal hyoid bone body morphology 2.681E-4 3.579E-2
3.124E-1
9.296E-1
 3 7
26 MP:0005197 abnormal uvea morphology 2.684E-4 3.579E-2
3.124E-1
9.306E-1
 12 179
27 MP:0000135 decreased compact bone thickness 3.063E-4 3.933E-2
3.433E-1
1.000E0
 8 85
28 MP:0000819 abnormal olfactory bulb morphology 3.499E-4 4.333E-2
3.782E-1
1.000E0
 11 158
29 MP:0000788 abnormal cerebral cortex morphology 3.640E-4 4.352E-2
3.798E-1
1.000E0
 18 361
30 MP:0000106 abnormal basisphenoid bone morphology 3.819E-4 4.413E-2
3.852E-1
1.000E0
 6 48
31 MP:0013498 trachea inflammation 4.066E-4 4.547E-2
3.969E-1
1.000E0
 2 2
32 MP:0002908 delayed wound healing 4.225E-4 4.577E-2
3.995E-1
1.000E0
 7 68
33 MP:0010876 decreased bone volume 4.528E-4 4.757E-2
4.152E-1
1.000E0
 8 90
Show 28 more annotations

6: Domain [Display Chart] 1472 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR013032 EGF-like CS InterPro 1.076E-8 1.019E-5 8.018E-5 1.584E-5 18 262
2 SM00181 EGF SMART 1.384E-8 1.019E-5 8.018E-5 2.037E-5 17 236
3 IPR000742 EGF-like dom InterPro 3.244E-8 1.592E-5 1.253E-4 4.775E-5 17 250
4 PS01186 EGF 2 PROSITE 8.011E-8 2.553E-5 2.010E-4 1.179E-4 17 266
5 PS50026 EGF 3 PROSITE 8.672E-8 2.553E-5 2.010E-4 1.276E-4 16 236
6 PS00022 EGF 1 PROSITE 2.637E-7 6.470E-5 5.093E-4 3.882E-4 16 256
7 SM00179 EGF CA SMART 4.492E-6 9.447E-4 7.436E-3 6.613E-3 10 122
8 IPR001881 EGF-like Ca-bd dom InterPro 5.199E-6 9.567E-4 7.531E-3 7.654E-3 10 124
9 2.120.10.30 - Gene3D 1.045E-5 1.708E-3 1.345E-2 1.538E-2 6 39
10 PF01391 Collagen Pfam 1.497E-5 2.004E-3 1.577E-2 2.204E-2 8 85
11 IPR008160 Collagen InterPro 1.497E-5 2.004E-3 1.577E-2 2.204E-2 8 85
12 IPR011042 6-blade b-propeller TolB-like InterPro 2.779E-5 3.409E-3 2.684E-2 4.091E-2 6 46
13 IPR009030 Growth fac rcpt InterPro 3.884E-5 4.003E-3 3.151E-2
5.718E-2
 10 156
14 IPR018097 EGF Ca-bd CS InterPro 3.932E-5 4.003E-3 3.151E-2
5.789E-2
 8 97
15 PF00008 EGF Pfam 4.080E-5 4.003E-3 3.151E-2
6.005E-2
 9 126
16 PS01187 EGF CA PROSITE 4.556E-5 4.191E-3 3.299E-2
6.706E-2
 8 99
17 PF08441 Integrin alpha2 Pfam 7.440E-5 5.476E-3 4.311E-2
1.095E-1
 4 18
18 IPR013649 Integrin alpha-2 InterPro 7.440E-5 5.476E-3 4.311E-2
1.095E-1
 4 18
19 PS00242 INTEGRIN ALPHA PROSITE 7.440E-5 5.476E-3 4.311E-2
1.095E-1
 4 18
20 IPR000413 Integrin alpha InterPro 7.440E-5 5.476E-3 4.311E-2
1.095E-1
 4 18
21 IPR013519 Int alpha beta-p InterPro 9.328E-5 6.241E-3 4.913E-2
1.373E-1
 4 19
22 SM00191 Int alpha SMART 9.328E-5 6.241E-3 4.913E-2
1.373E-1
 4 19
23 IPR001791 Laminin G InterPro 1.054E-4 6.747E-3
5.311E-2
1.552E-1
 6 58
24 PS51470 FG GAP PROSITE 1.707E-4 1.047E-2
8.243E-2
2.513E-1
 4 22
25 SM00210 TSPN SMART 2.046E-4 1.204E-2
9.481E-2
3.011E-1
 4 23
26 PF01839 FG-GAP Pfam 2.430E-4 1.280E-2
1.007E-1
3.577E-1
 4 24
27 IPR013517 FG-GAP InterPro 2.430E-4 1.280E-2
1.007E-1
3.577E-1
 4 24
28 2.60.120.200 - Gene3D 2.434E-4 1.280E-2
1.007E-1
3.583E-1
 7 95
29 IPR032695 Integrin dom InterPro 2.863E-4 1.453E-2
1.144E-1
4.215E-1
 4 25
30 PS00010 ASX HYDROXYL PROSITE 3.338E-4 1.638E-2
1.289E-1
4.914E-1
 7 100
31 IPR000152 EGF-type Asp/Asn hydroxyl site InterPro 4.758E-4 2.175E-2
1.712E-1
7.004E-1
 7 106
32 PF14719 PID 2 Pfam 5.024E-4 2.175E-2
1.712E-1
7.396E-1
 2 3
33 IPR026245 FRG2 InterPro 5.024E-4 2.175E-2
1.712E-1
7.396E-1
 2 3
34 PF15315 FRG2 Pfam 5.024E-4 2.175E-2
1.712E-1
7.396E-1
 2 3
35 PS51125 NHL PROSITE 5.666E-4 2.383E-2
1.876E-1
8.341E-1
 3 13
36 PS51120 LDLRB PROSITE 7.142E-4 2.842E-2
2.237E-1
1.000E0
 3 14
37 PF00058 Ldl recept b Pfam 7.142E-4 2.842E-2
2.237E-1
1.000E0
 3 14
38 PF00092 VWA Pfam 7.996E-4 3.098E-2
2.438E-1
1.000E0
 5 56
39 SM00135 LY SMART 8.842E-4 3.249E-2
2.557E-1
1.000E0
 3 15
40 IPR000033 LDLR classB rpt InterPro 8.842E-4 3.249E-2
2.557E-1
1.000E0
 3 15
41 PF07645 EGF CA Pfam 9.048E-4 3.249E-2
2.557E-1
1.000E0
 6 86
42 IPR003912 Protea act rcpt InterPro 9.962E-4 3.492E-2
2.748E-1
1.000E0
 2 4
43 IPR018184 Integrin alpha C CS InterPro 1.078E-3 3.690E-2
2.905E-1
1.000E0
 3 16
44 IPR000716 Thyroglobulin 1 InterPro 1.296E-3 3.894E-2
3.066E-1
1.000E0
 3 17
45 PF00086 Thyroglobulin 1 Pfam 1.296E-3 3.894E-2
3.066E-1
1.000E0
 3 17
46 SM00211 TY SMART 1.296E-3 3.894E-2
3.066E-1
1.000E0
 3 17
47 PS00484 THYROGLOBULIN 1 1 PROSITE 1.296E-3 3.894E-2
3.066E-1
1.000E0
 3 17
48 4.10.800.10 - Gene3D 1.296E-3 3.894E-2
3.066E-1
1.000E0
 3 17
49 PS51162 THYROGLOBULIN 1 2 PROSITE 1.296E-3 3.894E-2
3.066E-1
1.000E0
 3 17
50 SM00121 IB SMART 1.541E-3 4.178E-2
3.289E-1
1.000E0
 3 18
Show 45 more annotations

7: Pathway [Display Chart] 1147 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 576262 Extracellular matrix organization BioSystems: REACTOME 3.446E-16 3.953E-13 3.013E-12 3.953E-13 28 264
2 83068 ECM-receptor interaction BioSystems: KEGG 2.658E-12 1.524E-9 1.162E-8 3.049E-9 15 86
3 83067 Focal adhesion BioSystems: KEGG 3.161E-10 1.209E-7 9.214E-7 3.626E-7 19 206
4 645288 Collagen formation BioSystems: REACTOME 6.039E-10 1.732E-7 1.320E-6 6.927E-7 13 87
5 M5884 Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans MSigDB C2 BIOCARTA (v5.1) 1.156E-9 2.651E-7 2.021E-6 1.326E-6 21 275
6 P00034 Integrin signalling pathway PantherDB 4.950E-9 9.463E-7 7.213E-6 5.678E-6 16 167
7 730306 Assembly of collagen fibrils and other multimeric structures BioSystems: REACTOME 7.185E-9 1.177E-6 8.974E-6 8.241E-6 10 54
8 198795 Focal Adhesion BioSystems: WikiPathways 2.002E-8 2.870E-6 2.188E-5 2.296E-5 16 184
9 106028 Hemostasis BioSystems: REACTOME 2.839E-8 3.618E-6 2.758E-5 3.256E-5 26 493
10 106110 Integrin cell surface interactions BioSystems: REACTOME 5.409E-8 6.205E-6 4.729E-5 6.205E-5 10 66
11 645289 Collagen biosynthesis and modifying enzymes BioSystems: REACTOME 5.677E-7 5.919E-5 4.512E-4 6.511E-4 9 65
12 692234 PI3K-Akt signaling pathway BioSystems: KEGG 1.357E-6 1.297E-4 9.889E-4 1.557E-3 19 346
13 M3005 Genes encoding collagen proteins MSigDB C2 BIOCARTA (v5.1) 4.116E-6 3.631E-4 2.768E-3 4.721E-3 7 44
14 198812 Endochondral Ossification BioSystems: WikiPathways 6.854E-6 4.527E-4 3.450E-3 7.861E-3 8 66
15 M3008 Genes encoding structural ECM glycoproteins MSigDB C2 BIOCARTA (v5.1) 9.414E-6 4.527E-4 3.450E-3 1.080E-2 13 196
16 SMP00148 Enalapril Pathway SMPDB 1.105E-5 4.527E-4 3.450E-3 1.267E-2 6 34
17 SMP00145 Benazepril Pathway SMPDB 1.105E-5 4.527E-4 3.450E-3 1.267E-2 6 34
18 SMP00157 Trandolapril Pathway SMPDB 1.105E-5 4.527E-4 3.450E-3 1.267E-2 6 34
19 SMP00153 Quinapril Pathway SMPDB 1.105E-5 4.527E-4 3.450E-3 1.267E-2 6 34
20 SMP00152 Perindopril Pathway SMPDB 1.105E-5 4.527E-4 3.450E-3 1.267E-2 6 34
21 SMP00147 Cilazapril Pathway SMPDB 1.105E-5 4.527E-4 3.450E-3 1.267E-2 6 34
22 SMP00151 Moexipril Pathway SMPDB 1.105E-5 4.527E-4 3.450E-3 1.267E-2 6 34
23 SMP00146 Captopril Pathway SMPDB 1.105E-5 4.527E-4 3.450E-3 1.267E-2 6 34
24 SMP00155 Rescinnamine Pathway SMPDB 1.105E-5 4.527E-4 3.450E-3 1.267E-2 6 34
25 SMP00150 Lisinopril Pathway SMPDB 1.105E-5 4.527E-4 3.450E-3 1.267E-2 6 34
26 SMP00154 Ramipril Pathway SMPDB 1.105E-5 4.527E-4 3.450E-3 1.267E-2 6 34
27 SMP00156 Spirapril Pathway SMPDB 1.105E-5 4.527E-4 3.450E-3 1.267E-2 6 34
28 SMP00149 Fosinopril Pathway SMPDB 1.105E-5 4.527E-4 3.450E-3 1.267E-2 6 34
29 106061 Dissolution of Fibrin Clot BioSystems: REACTOME 1.604E-5 6.343E-4 4.835E-3 1.840E-2 4 11
30 906029 Laminin interactions BioSystems: REACTOME 2.125E-5 8.124E-4 6.192E-3 2.437E-2 5 23
31 161025 Smooth Muscle Contraction BioSystems: REACTOME 2.651E-5 9.808E-4 7.476E-3 3.041E-2 5 24
32 M5887 Genes encoding structural components of basement membranes MSigDB C2 BIOCARTA (v5.1) 2.923E-5 1.048E-3 7.987E-3 3.353E-2 6 40
33 M6487 Platelet Amyloid Precursor Protein Pathway MSigDB C2 BIOCARTA (v5.1) 4.693E-5 1.631E-3 1.243E-2
5.383E-2
 4 14
34 172847 Protein digestion and absorption BioSystems: KEGG 5.768E-5 1.946E-3 1.483E-2
6.616E-2
 8 88
35 P00050 Plasminogen activating cascade PantherDB 1.077E-4 3.437E-3 2.620E-2
1.235E-1
 4 17
36 106034 Platelet activation, signaling and aggregation BioSystems: REACTOME 1.079E-4 3.437E-3 2.620E-2
1.237E-1
 12 214
37 137960 Osteopontin-mediated events BioSystems: Pathway Interaction Database 1.138E-4 3.527E-3 2.688E-2
1.305E-1
 5 32
38 169349 Validated transcriptional targets of AP1 family members Fra1 and Fra2 BioSystems: Pathway Interaction Database 1.534E-4 4.629E-3 3.528E-2
1.759E-1
 5 34
39 833814 Scavenging by Class A Receptors BioSystems: REACTOME 1.712E-4 4.908E-3 3.742E-2
1.963E-1
 4 19
40 P00007 Axon guidance mediated by semaphorins PantherDB 1.712E-4 4.908E-3 3.742E-2
1.963E-1
 4 19
41 105688 Axon guidance BioSystems: REACTOME 1.901E-4 5.319E-3 4.054E-2
2.181E-1
 13 262
42 M15394 Acute Myocardial Infarction MSigDB C2 BIOCARTA (v5.1) 2.114E-4 5.774E-3 4.401E-2
2.425E-1
 4 20
43 M3270 Integrin Signaling Pathway MSigDB C2 BIOCARTA (v5.1) 2.509E-4 6.693E-3
5.102E-2
2.878E-1
 7 82
44 167324 Amoebiasis BioSystems: KEGG 2.599E-4 6.775E-3
5.164E-2
2.981E-1
 8 109
45 730308 Crosslinking of collagen fibrils BioSystems: REACTOME 2.761E-4 7.037E-3
5.364E-2
3.167E-1
 3 9
46 M3468 Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix MSigDB C2 BIOCARTA (v5.1) 2.908E-4 7.251E-3
5.527E-2
3.335E-1
 12 238
47 M8731 Aspirin Blocks Signaling Pathway Involved in Platelet Activation MSigDB C2 BIOCARTA (v5.1) 3.117E-4 7.607E-3
5.798E-2
3.575E-1
 4 22
48 P00011 Blood coagulation PantherDB 3.368E-4 8.048E-3
6.134E-2
3.863E-1
 5 40
49 576263 Degradation of the extracellular matrix BioSystems: REACTOME 4.159E-4 9.554E-3
7.282E-2
4.770E-1
 7 89
50 106384 Signaling by PDGF BioSystems: REACTOME 4.199E-4 9.554E-3
7.282E-2
4.816E-1
 10 179
Show 45 more annotations

8: Pubmed [Display Chart] 39011 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20628624 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". Pubmed 1.088E-17 2.123E-13 2.367E-12 4.246E-13 17 172
2 20628624:gr Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". GeneRIF 1.088E-17 2.123E-13 2.367E-12 4.246E-13 17 172
3 23333304 CBFÃ? stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Pubmed 1.127E-16 1.465E-12 1.634E-11 4.396E-12 16 163
4 21423176 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for Ã?-Pix in negative regulation of focal adhesion maturation. Pubmed 5.358E-14 5.226E-10 5.826E-9 2.090E-9 17 286
5 25241761 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. Pubmed 3.053E-13 1.916E-9 2.136E-8 1.191E-8 18 371
6 20673868:gr A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). GeneRIF 4.107E-13 1.916E-9 2.136E-8 1.602E-8 14 187
7 20673868 A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Pubmed 4.107E-13 1.916E-9 2.136E-8 1.602E-8 14 187
8 20452482:gr Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. GeneRIF 4.419E-13 1.916E-9 2.136E-8 1.724E-8 14 188
9 20452482 Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. Pubmed 4.419E-13 1.916E-9 2.136E-8 1.724E-8 14 188
10 23658023 Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. Pubmed 2.207E-12 8.108E-9 9.039E-8 8.611E-8 10 73
11 20551380 Proteomics characterization of extracellular space components in the human aorta. Pubmed 2.286E-12 8.108E-9 9.039E-8 8.919E-8 11 101
12 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 5.804E-12 1.742E-8 1.942E-7 2.264E-7 17 383
13 19453261:gr High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. GeneRIF 5.804E-12 1.742E-8 1.942E-7 2.264E-7 17 383
14 19199708 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Pubmed 1.893E-10 5.276E-7 5.882E-6 7.387E-6 16 414
15 20936779 A human MAP kinase interactome. Pubmed 2.340E-10 6.085E-7 6.784E-6 9.128E-6 17 486
16 22261194 Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Pubmed 7.804E-10 1.851E-6 2.064E-5 3.044E-5 8 64
17 23979707 SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Pubmed 8.067E-10 1.851E-6 2.064E-5 3.147E-5 10 131
18 2745554 SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix. Pubmed 1.020E-9 2.212E-6 2.466E-5 3.981E-5 5 11
19 19639654:gr Mutation of ACTA2 gene as an important cause of familial and nonfamilial nonsyndromatic thoracic aortic aneurysm and/or dissection (TAAD). GeneRIF 2.423E-9 4.725E-6 5.268E-5 9.451E-5 4 5
20 19639654 Mutation of ACTA2 gene as an important cause of familial and nonfamilial nonsyndromatic thoracic aortic aneurysm and/or dissection (TAAD). Pubmed 2.423E-9 4.725E-6 5.268E-5 9.451E-5 4 5
21 20301299 Thoracic Aortic Aneurysms and Aortic Dissections Pubmed 2.821E-9 5.240E-6 5.842E-5 1.100E-4 5 13
22 15324660 Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Pubmed 4.170E-9 7.394E-6 8.243E-5 1.627E-4 12 255
23 17934860 Mcp-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes in hepatopulmonary syndrome. Pubmed 7.241E-9 1.177E-5 1.312E-4 2.825E-4 4 6
24 17934860:gr Mcp-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes in hepatopulmonary syndrome. GeneRIF 7.241E-9 1.177E-5 1.312E-4 2.825E-4 4 6
25 23154389 Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Pubmed 8.555E-9 1.335E-5 1.488E-4 3.338E-4 6 32
26 24804215 Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line. Pubmed 9.463E-9 1.420E-5 1.583E-4 3.692E-4 5 16
27 12853948 The DNA sequence of human chromosome 7. Pubmed 2.883E-8 4.165E-5 4.644E-4 1.125E-3 14 438
28 24667918 Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02 AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. Pubmed 4.162E-8 5.799E-5 6.465E-4 1.624E-3 8 105
29 23383108 Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. Pubmed 5.191E-8 6.646E-5 7.410E-4 2.025E-3 8 108
30 19578796 Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. Pubmed 5.282E-8 6.646E-5 7.410E-4 2.060E-3 9 152
31 19578796:gr Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. GeneRIF 5.282E-8 6.646E-5 7.410E-4 2.060E-3 9 152
32 14627618 Smooth muscle contraction and relaxation. Pubmed 5.575E-8 6.796E-5 7.577E-4 2.175E-3 5 22
33 24503185 Interleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progression. Pubmed 6.015E-8 7.110E-5 7.927E-4 2.346E-3 4 9
34 20634891:gr Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. GeneRIF 7.399E-8 8.247E-5 9.195E-4 2.887E-3 12 331
35 20634891 Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Pubmed 7.399E-8 8.247E-5 9.195E-4 2.887E-3 12 331
36 19581412 Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. Pubmed 8.367E-8 9.067E-5 1.011E-3 3.264E-3 6 46
37 17022822 Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma. Pubmed 1.042E-7 1.070E-4 1.193E-3 4.065E-3 3 3
38 17022822:gr Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma. GeneRIF 1.042E-7 1.070E-4 1.193E-3 4.065E-3 3 3
39 24742657 Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins. Pubmed 1.371E-7 1.372E-4 1.529E-3 5.349E-3 5 26
40 20083228 Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India. Pubmed 2.925E-7 2.783E-4 3.103E-3 1.141E-2 5 30
41 20083228:gr Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India. GeneRIF 2.925E-7 2.783E-4 3.103E-3 1.141E-2 5 30
42 23788249 ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Pubmed 3.104E-7 2.883E-4 3.214E-3 1.211E-2 6 57
43 15778465 Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. Pubmed 3.235E-7 2.935E-4 3.272E-3 1.262E-2 7 93
44 23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Pubmed 3.474E-7 3.080E-4 3.434E-3 1.355E-2 5 31
45 19088796 Effect of oxidative stress on the expression of t-PA, u-PA, u-PAR, and PAI-1 in endothelial cells. Pubmed 4.153E-7 3.307E-4 3.687E-3 1.620E-2 3 4
46 25073002 Interactions between collagen gene variants and risk of anterior cruciate ligament rupture. Pubmed 4.153E-7 3.307E-4 3.687E-3 1.620E-2 3 4
47 19088796:gr Effect of oxidative stress on the expression of t-PA, u-PA, u-PAR, and PAI-1 in endothelial cells. GeneRIF 4.153E-7 3.307E-4 3.687E-3 1.620E-2 3 4
48 24793577 The spectrum of FBN1, TGFÃ?R1, TGFÃ?R2 and ACTA2 variants in 594 individuals with suspected Marfan Syndrome, Loeys-Dietz Syndrome or Thoracic Aortic Aneurysms and Dissections (TAAD). Pubmed 4.153E-7 3.307E-4 3.687E-3 1.620E-2 3 4
49 23818951 Genome-wide DNA methylation analysis reveals a potential mechanism for the pathogenesis and development of uterine leiomyomas. Pubmed 4.153E-7 3.307E-4 3.687E-3 1.620E-2 3 4
50 23419831 APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Pubmed 4.690E-7 3.659E-4 4.080E-3 1.830E-2 4 14
Show 45 more annotations

9: Interaction [Display Chart] 4487 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:MYH9 MYH9 interactions 2.530E-8 1.135E-4 1.020E-3 1.135E-4 20 319
2 int:MYO18A MYO18A interactions 6.306E-8 1.415E-4 1.271E-3 2.829E-4 14 161
3 int:THBS1 THBS1 interactions 3.659E-7 5.473E-4 4.918E-3 1.642E-3 8 49
4 int:MYO19 MYO19 interactions 8.879E-7 8.593E-4 7.722E-3 3.984E-3 13 171
5 int:ANLN ANLN interactions 9.575E-7 8.593E-4 7.722E-3 4.296E-3 12 145
6 int:TMEM25 TMEM25 interactions 1.420E-6 1.062E-3 9.545E-3 6.373E-3 9 78
7 int:F2 F2 interactions 2.410E-6 1.545E-3 1.388E-2 1.081E-2 7 44
8 int:MAG MAG interactions 6.801E-6 3.815E-3 3.428E-2 3.052E-2 5 20
9 int:YWHAG YWHAG interactions 9.684E-6 4.828E-3 4.339E-2 4.345E-2 18 388
10 int:MYH2 MYH2 interactions 1.129E-5 5.066E-3 4.552E-2
5.066E-2
 5 22
11 int:COL1A1 COL1A1 interactions 1.601E-5 6.529E-3
5.867E-2
7.182E-2
 7 58
12 int:IQGAP1 IQGAP1 interactions 2.164E-5 7.597E-3
6.826E-2
9.711E-2
 14 263
13 int:SPARC SPARC interactions 2.201E-5 7.597E-3
6.826E-2
9.876E-2
 5 25
14 int:LAMA3 LAMA3 interactions 2.445E-5 7.837E-3
7.042E-2
1.097E-1
 4 13
15 int:CD82 CD82 interactions 2.825E-5 8.452E-3
7.595E-2
1.268E-1
 6 43
16 int:PLG PLG interactions 3.770E-5 1.057E-2
9.500E-2
1.691E-1
 7 66
17 int:PTCH1 PTCH1 interactions 5.669E-5 1.422E-2
1.278E-1
2.544E-1
 8 95
18 int:PDGFA PDGFA interactions 6.021E-5 1.422E-2
1.278E-1
2.702E-1
 4 16
19 int:BMP1 BMP1 interactions 6.021E-5 1.422E-2
1.278E-1
2.702E-1
 4 16
20 int:SYNPO SYNPO interactions 6.418E-5 1.440E-2
1.294E-1
2.880E-1
 10 154
21 int:FLNA FLNA interactions 9.043E-5 1.867E-2
1.678E-1
4.058E-1
 14 300
22 int:COL13A1 COL13A1 interactions 9.156E-5 1.867E-2
1.678E-1
4.108E-1
 3 7
23 int:PPP1CB PPP1CB interactions 9.769E-5 1.906E-2
1.713E-1
4.383E-1
 12 229
24 int:MMP1 MMP1 interactions 1.241E-4 2.319E-2
2.084E-1
5.566E-1
 4 19
25 int:ITGB1 ITGB1 interactions 1.498E-4 2.689E-2
2.416E-1
6.722E-1
 8 109
26 int:YWHAE YWHAE interactions 1.663E-4 2.870E-2
2.579E-1
7.462E-1
 18 483
27 int:SH3KBP1 SH3KBP1 interactions 1.757E-4 2.920E-2
2.624E-1
7.884E-1
 11 208
28 int:SERPINE2 SERPINE2 interactions 1.874E-4 3.003E-2
2.698E-1
8.408E-1
 4 21
29 int:LAMA1 LAMA1 interactions 2.033E-4 3.145E-2
2.826E-1
9.120E-1
 5 39
30 int:CAPZA2 CAPZA2 interactions 2.219E-4 3.279E-2
2.946E-1
9.955E-1
 12 250
31 int:PDGFB PDGFB interactions 2.265E-4 3.279E-2
2.946E-1
1.000E0
 4 22
32 int:IDS IDS interactions 2.586E-4 3.626E-2
3.259E-1
1.000E0
 5 41
33 int:CBL CBL interactions 2.857E-4 3.830E-2
3.442E-1
1.000E0
 12 257
34 int:COL4A2 COL4A2 interactions 2.902E-4 3.830E-2
3.442E-1
1.000E0
 5 42
35 int:CD151 CD151 interactions 3.043E-4 3.901E-2
3.505E-1
1.000E0
 3 10
36 int:SERPINE1 SERPINE1 interactions 3.219E-4 3.903E-2
3.508E-1
1.000E0
 4 24
37 int:ELN ELN interactions 3.219E-4 3.903E-2
3.508E-1
1.000E0
 4 24
38 int:LYN LYN interactions 3.459E-4 4.021E-2
3.614E-1
1.000E0
 11 225
39 int:ACTC1 ACTC1 interactions 3.495E-4 4.021E-2
3.614E-1
1.000E0
 6 67
40 int:CD44 CD44 interactions 4.102E-4 4.601E-2
4.135E-1
1.000E0
 6 69
41 int:VCAN VCAN interactions 4.430E-4 4.848E-2
4.357E-1
1.000E0
 4 26
42 int:TGFBR1 TGFBR1 interactions 4.585E-4 4.898E-2
4.401E-1
1.000E0
 10 196
Show 37 more annotations

10: Cytoband [Display Chart] 210 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 14q24.2-q24.3 14q24.2-q24.3 4.935E-5 6.548E-3 3.881E-2 1.036E-2 2 2
2 2q31.3 2q31.3 9.354E-5 6.548E-3 3.881E-2 1.964E-2 3 13
3 7q21 7q21 9.354E-5 6.548E-3 3.881E-2 1.964E-2 3 13
4 5q13 5q13 4.806E-4 2.523E-2
1.496E-1
1.009E-1
 3 22
5 4p16.2 4p16.2 7.266E-4 3.052E-2
1.809E-1
1.526E-1
 2 6

11: Transcription Factor Binding Site [Display Chart] 526 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 131 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 490 Collagens genenames.org 1.840E-7 2.410E-5 1.315E-4 2.410E-5 7 46
2 471 CD molecules|V-set domain containing|Immunoglobulin like domain containing|Carcinoembryonic antigen related cell adhesion molecule family genenames.org 1.582E-5 8.082E-4 4.410E-3 2.073E-3 14 394
3 1160 CD molecules|Integrin alpha subunits genenames.org 1.851E-5 8.082E-4 4.410E-3 2.425E-3 4 18
4 219 F2R receptors genenames.org 4.905E-4 1.607E-2
8.766E-2
6.426E-2
 2 4
5 555 Fibronectin type III domain containing|Immunoglobulin like domain containing genenames.org 6.725E-4 1.656E-2
9.037E-2
8.810E-2
 7 160
6 390 Rho family GTPases genenames.org 7.586E-4 1.656E-2
9.037E-2
9.938E-2
 3 20
7 1065 Insulin like growth factor binding proteins genenames.org 1.212E-3 2.075E-2
1.132E-1
1.587E-1
 2 6
8 760 Fibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors genenames.org 1.267E-3 2.075E-2
1.132E-1
1.660E-1
 5 88
9 1253 C2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors genenames.org 1.857E-3 2.697E-2
1.472E-1
2.433E-1
 3 27
10 1218 LIM domain containing genenames.org 2.059E-3 2.697E-2
1.472E-1
2.697E-1
 4 59
11 457 BRICHOS domain containing genenames.org 2.856E-3 3.401E-2
1.856E-1
3.742E-1
 2 9
Show 6 more annotations

13: Coexpression [Display Chart] 6999 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v5.1) 1.796E-34 1.257E-30 1.186E-29 1.257E-30 37 200
2 M13206 Genes down-regulated in TC71 and EWS502 cells (Ewing's sarcoma) by EWSR1-FLI1 [GeneID=2130;2314] as inferred from RNAi knockdown of this fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.536E-29 2.987E-25 2.817E-24 5.974E-25 39 326
3 M1804 Genes up-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.907E-28 2.311E-24 2.180E-23 6.934E-24 36 280
4 M2293 Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.744E-27 8.301E-24 7.828E-23 3.320E-23 37 315
5 M17471 Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS, non-invasive). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.348E-25 3.287E-22 3.100E-21 1.644E-21 37 351
6 M15981 Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.876E-24 3.355E-21 3.164E-20 2.013E-20 39 430
7 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.433E-24 3.433E-21 3.237E-20 2.403E-20 40 460
8 M4995 Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.857E-24 8.623E-21 8.133E-20 6.899E-20 37 390
9 M259 Genes up-regulated in response to both hypoxia and overexpression of an active form of HIF1A [GeneID=3091]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.439E-20 4.230E-17 3.989E-16 3.807E-16 26 207
10 M14507 Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.548E-19 1.083E-16 1.022E-15 1.083E-15 35 454
11 M12225 Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.041E-19 3.844E-16 3.625E-15 4.228E-15 25 205
12 M2573 Genes consistently up-regulated in mammary stem cells both in mouse and human species. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.651E-18 9.630E-16 9.081E-15 1.156E-14 35 489
13 M3645 Genes up-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.192E-17 2.257E-14 2.128E-13 2.934E-13 32 443
14 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.027E-16 5.133E-14 4.841E-13 7.186E-13 31 425
15 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.883E-16 8.784E-14 8.284E-13 1.318E-12 25 260
16 M178 Tumorigenesis markers of head and neck squamous cell carcinoma (HNSCC): up-regulated in the 'early' tumors vs normal samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.397E-16 1.049E-13 9.890E-13 1.678E-12 15 63
17 M15491 Genes down-regulated in MDA-MB-231 cells (breast cancer) after knockdown of SATB1 [GeneID=6304] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.076E-16 1.266E-13 1.194E-12 2.153E-12 31 442
18 M17079 Up-regulated genes distinguishing between two subtypes of gastric cancer: advanced (AGC) and early (EGC). MSigDB C2: CGP Curated Gene Sets (v5.1) 6.020E-16 2.341E-13 2.208E-12 4.213E-12 21 175
19 M1973 Genes up-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [GeneID=9589] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.788E-16 2.500E-13 2.358E-12 4.751E-12 26 302
20 M1459 Genes up-regulated in BEC (blood endothelial cells) compared to LEC (lymphatic endothelial cells). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.741E-15 6.093E-13 5.746E-12 1.219E-11 20 162
21 M4737 ECM related genes up-regulated early (within 30 min) in dermal fibroblasts after addition of TGFB1 [GeneID=7040]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.976E-15 6.587E-13 6.212E-12 1.383E-11 14 58
22 M4306 Genes down-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.458E-15 2.675E-12 2.523E-11 5.920E-11 30 464
23 M2572 Genes in the 'mesenchymal transition signature' common to all invasive cancer types. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.791E-15 2.675E-12 2.523E-11 6.153E-11 14 64
24 M2310 Genes down-regulated by MYC [GeneID=4609], according to the MYC Target Gene Database. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.076E-14 3.138E-12 2.960E-11 7.532E-11 23 253
25 M13867 Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.388E-14 3.885E-12 3.664E-11 9.713E-11 23 256
26 M2855 Genes up-regulated in NOMO-1 cells (AML) after knockdown of STK33 [Gene ID=65975] by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 2.436E-14 6.559E-12 6.186E-11 1.705E-10 24 291
27 M12890 Genes up-regulated in HT1080 cells (fibrosarcoma) over-expressing MMP14 [GeneID=4323] compared to those with knockdown of the gene by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.161E-14 8.194E-12 7.727E-11 2.212E-10 23 266
28 M1278 Genes down-regulated in pulpal tissue extracted from carious teeth. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.954E-14 1.238E-11 1.168E-10 3.467E-10 22 244
29 M19467 Genes down-regulated in five primary endothelial cell types (lung, aortic, iliac, dermal, and colon) by TNF [GeneID=7124]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.894E-14 1.664E-11 1.569E-10 4.825E-10 15 90
30 M5311 Genes from 'subtype S1' signature of hepatocellular carcinoma (HCC): aberrant activation of the WNT signaling pathway. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.681E-13 6.256E-11 5.900E-10 1.877E-9 21 237
31 M10117 Genes down-regulated in acute myeloid leukemia (AML) patients with mutated NPM1 [GeneID=4869]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.558E-13 1.255E-10 1.183E-9 3.890E-9 21 246
32 M7363 Genes up-regulated in MCF7 cells (breast cancer) under hypoxia conditions. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.592E-13 1.661E-10 1.566E-9 5.314E-9 18 171
33 M2769 Genes down-regulated during early stages of differentiation of embryoid bodies from V6.5 embryonic stem cells. MSigDB C6: Oncogenic Signatures (v5.1) 8.396E-13 1.781E-10 1.679E-9 5.877E-9 18 172
34 GSE21546 UNSTIM VS ANTI CD3 STIM SAP1A KO DP THYMOCYTES UP Genes up-regulated in double positive thymocytes with ELK4 [GeneID=2005] knockout: untreated versus stimulated by anti-CD3. MSigDB C7: Immunologic Signatures (v5.1) 1.004E-12 2.067E-10 1.949E-9 7.026E-9 19 199
35 M4680 Genes up-regulated in RD cells (embryonal rhabdomyosarcoma, ERMS) by expression of PAX3- or PAX7-FOXO1 [GeneID=5077;5081;2308] fusions off retroviral vectors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.117E-12 2.234E-10 2.107E-9 7.821E-9 21 255
36 M14973 Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC1 [GeneID=3065] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.705E-12 3.315E-10 3.126E-9 1.193E-8 27 457
37 M9143 Genes up-regulated in senescent cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.797E-12 5.290E-10 4.989E-9 1.957E-8 13 77
38 M4665 Genes down-regulated in glomeruli of kidneys from patients with diabetic nephropathy (type 2 diabetes mellitus). MSigDB C2: CGP Curated Gene Sets (v5.1) 3.304E-12 6.085E-10 5.738E-9 2.312E-8 26 434
39 M19391 Genes down-regulated in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.335E-12 9.575E-10 9.030E-9 3.734E-8 27 480
40 M2634 Genes up-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] and engineered to express ligand-activatable EGFR [Gene ID=1956]. MSigDB C6: Oncogenic Signatures (v5.1) 6.025E-12 1.054E-9 9.942E-9 4.217E-8 18 193
41 M2726 Genes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] MCF-7 cells (breast cancer) stably over-expressing constitutively active RAF1 [Gene ID=5894] gene. MSigDB C6: Oncogenic Signatures (v5.1) 6.576E-12 1.123E-9 1.059E-8 4.603E-8 18 194
42 M5184 Genes down-regulated in comparison of dendritic cells (DC) exposed to T. gondii versus macrophages exposed to T. gondii. MSigDB C7: Immunologic Signatures (v5.1) 1.011E-11 1.685E-9 1.589E-8 7.075E-8 18 199
43 M2256 Genes commonly down-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313 ,2078]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.041E-11 1.694E-9 1.598E-8 7.286E-8 19 227
44 M15193 Genes up-regulated in pancreatic ductal adenocarcinoma (PDAC) identified in a meta analysis across four independent studies. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.542E-11 2.454E-9 2.314E-8 1.080E-7 23 358
45 M1565 Genes up-regulated in MMEC cells (myometrial endothelium) by VEGFA [GeneID=7422] stimulation. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.666E-11 2.591E-9 2.443E-8 1.166E-7 14 108
46 M9197 Genes up-regulated in MCF7 cells (breast cancer) treated with hypoxia mimetic DMOG [PubChem=3080614]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.717E-11 2.613E-9 2.464E-8 1.202E-7 15 130
47 M9639 Genes up-regulated in MDA-MB-231 cells (breast cancer) after knockdown of SATB1 [GeneID=6304] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.758E-11 2.617E-9 2.468E-8 1.230E-7 24 395
48 M7137 Genes most down-regulated in hypoxia tolerant NCI H460 cells (lung cancer). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.978E-11 2.884E-9 2.720E-8 1.384E-7 10 41
49 M18938 Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of both HDAC1 and HDAC2 [GeneID=3065;3066] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.382E-11 3.403E-9 3.209E-8 1.667E-7 19 238
50 M19432 Genes up-regulated during pubertal mammary gland development between week 4 and 5. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.916E-11 4.082E-9 3.849E-8 2.041E-7 20 271
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 3580 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 1.198E-34 4.288E-31 3.757E-30 4.288E-31 50 445
2 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 6.934E-31 1.241E-27 1.087E-26 2.482E-27 47 455
3 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 1.823E-29 2.175E-26 1.905E-25 6.525E-26 45 438
4 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 9.508E-27 8.509E-24 7.454E-23 3.404E-23 43 453
5 GSM777059 500 Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 3.139E-24 2.125E-21 1.862E-20 1.124E-20 40 439
6 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 3.562E-24 2.125E-21 1.862E-20 1.275E-20 42 496
7 GSM777063 500 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 7.696E-23 3.936E-20 3.448E-19 2.755E-19 39 450
8 endothelial SubClass DCN-hi Top 500 All endothelial SubClass DCN-hi Top 500 All Brain Map - Barres 2.745E-22 1.174E-19 1.028E-18 9.827E-19 40 495
9 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 2.951E-22 1.174E-19 1.028E-18 1.056E-18 39 467
10 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 2.224E-21 7.963E-19 6.976E-18 7.963E-18 39 494
11 GSM777037 500 Stromal Cells, BEC.SLN, gp38- CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.284E-20 4.180E-18 3.662E-17 4.598E-17 37 459
12 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 1.489E-20 4.442E-18 3.892E-17 5.331E-17 37 461
13 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 1.139E-18 3.138E-16 2.749E-15 4.079E-15 36 493
14 JC fibro 1000 K1 JC fibro top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 1.288E-18 3.295E-16 2.886E-15 4.613E-15 35 464
15 gudmap dev gonad e13.5 M InterstitTestis Sma 500 dev gonad e13.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.810E-18 9.094E-16 7.967E-15 1.364E-14 31 362
16 gudmap dev gonad e12.5 M InterstitLeydig MafB 500 dev gonad e12.5 M InterstitLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.968E-17 8.419E-15 7.375E-14 1.421E-13 30 364
17 ratio EB vs SC 1000 K1 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 3.998E-17 8.419E-15 7.375E-14 1.431E-13 29 336
18 GSM777032 500 Stromal Cells, BEC.MLN, gp38- CD31+, Lymph Node, avg-5 Immgen.org, GSE15907 4.645E-17 8.752E-15 7.667E-14 1.663E-13 33 456
19 gudmap kidney P0 JuxtaGlom Ren1 500 kidney P0 JuxtaGlom Ren1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.645E-17 8.752E-15 7.667E-14 1.663E-13 33 456
20 gudmap dev gonad e11.5 M GonMes Sma k3 1000 dev gonad e11.5 M GonMes Sma k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 5.222E-17 9.347E-15 8.189E-14 1.869E-13 28 312
21 54Dn SubClass 54Dn 1SK Top 500 Cluster 2 54Dn SubClass 54Dn 1SK Top 500 Cluster 2 Brain Map - Allen iN 8.209E-17 1.399E-14 1.226E-13 2.939E-13 26 265
22 PCBC ratio ECTO blastocyst vs ECTO UCB CD34+Z cfr-2X-p05 ECTO blastocyst vs ECTO UCB CD34+Z-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.089E-16 1.772E-14 1.553E-13 3.899E-13 27 294
23 GSM777067 100 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 1.182E-16 1.840E-14 1.612E-13 4.232E-13 17 85
24 Lungmap Mouse e16.5 Myofibro Top 500 All Lungmap Mouse e16.5 Myofibro Top 500 All Lungmap Mouse Single Cell (Lungmap.net) 2.573E-16 3.838E-14 3.362E-13 9.211E-13 31 420
25 gudmap dev gonad e13.5 M InterstitFLeydig MafB k3 1000 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.577E-16 5.123E-14 4.488E-13 1.281E-12 28 336
26 gudmap kidney adult Mesangium Meis 500 kidney adult Mesangium Meis top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.648E-16 6.400E-14 5.606E-13 1.664E-12 31 429
27 PCBC ctl CardiacMyocyte 500 Progenitor-Cell-Biology-Consortium reference CardiacMyocyte top-relative-expression-ranked 500 PCBC 5.193E-16 6.886E-14 6.032E-13 1.859E-12 33 495
28 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB k2 1000 dev gonad e13.5 F VascAssocMesenchStromOvary MafB k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 9.135E-16 1.168E-13 1.023E-12 3.270E-12 25 266
29 GSM777043 100 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 1.236E-15 1.526E-13 1.337E-12 4.425E-12 17 97
30 gudmap dev gonad e13.5 M InterstitFLeydig MafB 500 dev gonad e13.5 M InterstitFLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.577E-15 1.882E-13 1.649E-12 5.645E-12 28 356
31 gudmap dev gonad e11.5 M GonadVasMes Flk k1 1000 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.551E-15 4.101E-13 3.593E-12 1.271E-11 27 338
32 80Dn Top 500 Cluster 2 80Dn Top 500 Cluster 2 Brain Map - Allen iN 3.890E-15 4.352E-13 3.813E-12 1.393E-11 23 231
33 gudmap dev gonad e12.5 M InterstitTestis Sma 500 dev gonad e12.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 5.519E-15 5.988E-13 5.246E-12 1.976E-11 28 374
34 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.662E-15 8.068E-13 7.068E-12 2.743E-11 29 410
35 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma k4 1000 dev gonad e13.5 F VascAssocMesenchStromOvary Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 8.327E-15 8.517E-13 7.461E-12 2.981E-11 20 168
36 gudmap dev gonad e11.5 F GonMes Sma k4 1000 dev gonad e11.5 F GonMes Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.424E-14 1.416E-12 1.240E-11 5.096E-11 26 328
37 gudmap kidney adult JuxtaGlom Ren1 Captopr k4 1000 kidney adult JuxtaGlom Ren1 Captopr k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.851E-14 2.758E-12 2.416E-11 1.021E-10 20 179
38 gudmap dev gonad e12.5 M InterstitLeydig MafB k2 500 dev gonad e12.5 M InterstitLeydig MafB k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 7.377E-14 6.950E-12 6.088E-11 2.641E-10 19 165
39 gudmap dev gonad e11.5 M GonadVasMes Flk 500 dev gonad e11.5 M GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 9.441E-14 8.666E-12 7.592E-11 3.380E-10 28 419
40 DevelopingLowerUrinaryTract e14.5 bladder emap-6668 500 DevelopingLowerUrinaryTract e14.5 bladder emap-6668 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.126E-13 1.008E-11 8.827E-11 4.030E-10 28 422
41 gudmap dev gonad e13.5 M InterstitTestis Sma 200 dev gonad e13.5 M InterstitTestis Sma top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 1.309E-13 1.143E-11 1.002E-10 4.687E-10 18 148
42 astrocytes Top 500 All astrocytes Top 500 All Brain Map - Barres 1.575E-13 1.343E-11 1.176E-10 5.639E-10 30 496
43 gudmap dev gonad e13.5 M InterstitTestis Sma k1 500 dev gonad e13.5 M InterstitTestis Sma k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.295E-13 2.743E-11 2.403E-10 1.179E-9 18 156
44 endothelial Top 500 Cluster 4 endothelial Top 500 Cluster 4 Brain Map - Barres 3.839E-13 3.123E-11 2.736E-10 1.374E-9 22 258
45 GSM538239 500 Myeloid Cells, DC.103-11b+.Lv, CD45+ CD11c+ MHC-II + CD11b high CD103-, Liver, avg-3 Immgen.org, GSE15907 4.034E-13 3.209E-11 2.811E-10 1.444E-9 27 411
46 JC fibro 500 K3 JC fibro top-relative-expression-ranked 500 k-means-cluster#3 PCBC 4.166E-13 3.242E-11 2.840E-10 1.491E-9 20 206
47 gudmap dev gonad e12.5 M gudmap devVasTestis Flk 500 dev gonad e12.5 M DevVasTestis Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.792E-13 3.650E-11 3.198E-10 1.716E-9 27 414
48 gudmap dev gonad e12.5 F gudmap devVasOvary Flk 500 dev gonad e12.5 F DevVasOvary Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 5.074E-13 3.784E-11 3.315E-10 1.816E-9 27 415
49 gudmap dev gonad e13.5 F gudmap devVascOvary Flk 500 dev gonad e13.5 F DevVascOvary Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 5.371E-13 3.924E-11 3.438E-10 1.923E-9 27 416
50 GSM538280 500 Myeloid Cells, DC.LC.Sk, MHCII+ CD11b+ CD45+, Skin, avg-2 Immgen.org, GSE15907 6.046E-13 4.329E-11 3.792E-10 2.164E-9 28 452
Show 45 more annotations

15: Computational [Display Chart] 443 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 6.780E-22 3.004E-19 2.004E-18 3.004E-19 34 216
2 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 8.192E-16 1.814E-13 1.211E-12 3.629E-13 36 378
3 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 1.263E-15 1.865E-13 1.244E-12 5.595E-13 35 361
4 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 3.519E-15 3.897E-13 2.600E-12 1.559E-12 34 351
5 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 6.447E-13 5.712E-11 3.811E-10 2.856E-10 34 419
6 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 8.465E-13 6.250E-11 4.170E-10 3.750E-10 34 423
7 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 9.253E-11 5.856E-9 3.907E-8 4.099E-8 30 395
8 module 3 Genes in module 3 MSigDb: C4 - CM: Cancer Modules 2.919E-9 1.616E-7 1.078E-6 1.293E-6 27 375
9 module 6 Genes in module 6 MSigDb: C4 - CM: Cancer Modules 3.981E-9 1.944E-7 1.297E-6 1.764E-6 28 407
10 module 18 Genes in module 18 MSigDb: C4 - CM: Cancer Modules 4.388E-9 1.944E-7 1.297E-6 1.944E-6 29 436
11 module 122 Genes in module 122 MSigDb: C4 - CM: Cancer Modules 8.624E-9 3.473E-7 2.317E-6 3.820E-6 16 138
12 GNF2 PTX3 Neighborhood of PTX3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.885E-8 6.957E-7 4.642E-6 8.349E-6 9 36
13 module 128 Genes in module 128 MSigDb: C4 - CM: Cancer Modules 4.484E-8 1.528E-6 1.019E-5 1.986E-5 13 98
14 module 79 Genes in module 79 MSigDb: C4 - CM: Cancer Modules 5.736E-8 1.694E-6 1.130E-5 2.541E-5 13 100
15 module 170 Genes in module 170 MSigDb: C4 - CM: Cancer Modules 5.736E-8 1.694E-6 1.130E-5 2.541E-5 13 100
16 module 220 Genes in module 220 MSigDb: C4 - CM: Cancer Modules 7.914E-8 2.191E-6 1.462E-5 3.506E-5 23 328
17 GNF2 MMP1 Neighborhood of MMP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.198E-7 3.123E-6 2.083E-5 5.308E-5 8 32
18 module 44 Genes in module 44 MSigDb: C4 - CM: Cancer Modules 2.077E-7 5.113E-6 3.411E-5 9.203E-5 22 319
19 module 129 Genes in module 129 MSigDb: C4 - CM: Cancer Modules 4.452E-6 1.038E-4 6.925E-4 1.972E-3 16 217
20 GNF2 CDH11 Neighborhood of CDH11 MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.330E-6 1.402E-4 9.355E-4 2.804E-3 6 25
21 module 38 Genes in module 38 MSigDb: C4 - CM: Cancer Modules 2.185E-5 4.609E-4 3.075E-3 9.680E-3 23 455
22 module 234 Genes in module 234 MSigDb: C4 - CM: Cancer Modules 6.608E-5 1.331E-3 8.878E-3 2.927E-2 7 53
23 module 324 Genes in module 324 MSigDb: C4 - CM: Cancer Modules 2.205E-4 4.247E-3 2.834E-2
9.768E-2
 10 131
24 module 423 Genes in module 423 MSigDb: C4 - CM: Cancer Modules 2.361E-4 4.357E-3 2.907E-2
1.046E-1
 3 7
25 module 19 Genes in module 19 MSigDb: C4 - CM: Cancer Modules 2.969E-4 5.262E-3 3.510E-2
1.315E-1
 16 307
26 module 513 Genes in module 513 MSigDb: C4 - CM: Cancer Modules 3.723E-4 6.344E-3 4.232E-2
1.649E-1
 3 8
27 module 131 Genes in module 131 MSigDb: C4 - CM: Cancer Modules 3.938E-4 6.461E-3 4.311E-2
1.744E-1
 5 33
28 module 105 Genes in module 105 MSigDb: C4 - CM: Cancer Modules 1.355E-3 2.110E-2
1.408E-1
6.001E-1
 11 194
29 module 190 Genes in module 190 MSigDb: C4 - CM: Cancer Modules 1.381E-3 2.110E-2
1.408E-1
6.119E-1
 3 12
30 module 259 Genes in module 259 MSigDb: C4 - CM: Cancer Modules 1.857E-3 2.742E-2
1.829E-1
8.225E-1
 5 46
31 module 33 Genes in module 33 MSigDb: C4 - CM: Cancer Modules 2.297E-3 3.283E-2
2.191E-1
1.000E0
 16 372
32 module 474 Genes in module 474 MSigDb: C4 - CM: Cancer Modules 3.321E-3 4.458E-2
2.975E-1
1.000E0
 3 16
33 module 401 Genes in module 401 MSigDb: C4 - CM: Cancer Modules 3.321E-3 4.458E-2
2.975E-1
1.000E0
 3 16
Show 28 more annotations

16: MicroRNA [Display Chart] 1386 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-145:PITA hsa-miR-145:PITA TOP PITA 5.475E-9 7.588E-6 5.927E-5 7.588E-6 22 401
2 hsa-miR-199b-3p:PITA hsa-miR-199b-3p:PITA TOP PITA 3.304E-8 1.527E-5 1.193E-4 4.580E-5 18 298
3 hsa-miR-199a-3p:PITA hsa-miR-199a-3p:PITA TOP PITA 3.304E-8 1.527E-5 1.193E-4 4.580E-5 18 298
4 hsa-miR-485-3p:PITA hsa-miR-485-3p:PITA TOP PITA 6.602E-8 1.866E-5 1.458E-4 9.151E-5 21 422
5 hsa-miR-29c:miRTarbase hsa-miR-29c:miRTarbase miRTarbase 7.972E-8 1.866E-5 1.458E-4 1.105E-4 7 31
6 hsa-miR-211:PITA hsa-miR-211:PITA TOP PITA 9.425E-8 1.866E-5 1.458E-4 1.306E-4 21 431
7 hsa-miR-204:PITA hsa-miR-204:PITA TOP PITA 9.425E-8 1.866E-5 1.458E-4 1.306E-4 21 431
8 hsa-miR-363:PITA hsa-miR-363:PITA TOP PITA 1.656E-7 1.981E-5 1.547E-4 2.295E-4 22 486
9 hsa-miR-25:PITA hsa-miR-25:PITA TOP PITA 1.715E-7 1.981E-5 1.547E-4 2.377E-4 22 487
10 hsa-miR-92a:PITA hsa-miR-92a:PITA TOP PITA 1.715E-7 1.981E-5 1.547E-4 2.377E-4 22 487
11 hsa-miR-367:PITA hsa-miR-367:PITA TOP PITA 1.715E-7 1.981E-5 1.547E-4 2.377E-4 22 487
12 hsa-miR-92b:PITA hsa-miR-92b:PITA TOP PITA 1.715E-7 1.981E-5 1.547E-4 2.377E-4 22 487
13 hsa-miR-452:PITA hsa-miR-452:PITA TOP PITA 2.009E-7 2.142E-5 1.674E-4 2.785E-4 21 451
14 hsa-miR-29a:miRTarbase hsa-miR-29a:miRTarbase miRTarbase 4.288E-7 4.245E-5 3.316E-4 5.944E-4 7 39
15 hsa-miR-32:PITA hsa-miR-32:PITA TOP PITA 5.583E-7 5.158E-5 4.030E-4 7.737E-4 21 480
16 hsa-miR-148a:PITA hsa-miR-148a:PITA TOP PITA 6.176E-7 5.350E-5 4.179E-4 8.559E-4 21 483
17 hsa-miR-29c:miRecords TarBase hsa-miR-29c:miRecords TarBase miRecords_TarBase 7.327E-7 5.973E-5 4.666E-4 1.015E-3 5 15
18 miR-23a:PicTar miR-23a:PicTar PicTar 1.290E-6 9.933E-5 7.759E-4 1.788E-3 19 422
19 miR-23b:PicTar miR-23b:PicTar PicTar 1.384E-6 1.009E-4 7.884E-4 1.918E-3 19 424
20 hsa-miR-1279:PITA hsa-miR-1279:PITA TOP PITA 1.578E-6 1.093E-4 8.540E-4 2.186E-3 14 238
21 miR-25:PicTar miR-25:PicTar PicTar 1.725E-6 1.138E-4 8.894E-4 2.391E-3 16 312
22 AATGTGA,MIR-23A:MSigDB AATGTGA,MIR-23A:MSigDB MSigDB 2.163E-6 1.249E-4 9.761E-4 2.998E-3 18 396
23 AATGTGA,MIR-23B:MSigDB AATGTGA,MIR-23B:MSigDB MSigDB 2.163E-6 1.249E-4 9.761E-4 2.998E-3 18 396
24 TTTGCAC,MIR-19B:MSigDB TTTGCAC,MIR-19B:MSigDB MSigDB 2.434E-6 1.249E-4 9.761E-4 3.374E-3 20 483
25 hsa-miR-148b:PITA hsa-miR-148b:PITA TOP PITA 2.434E-6 1.249E-4 9.761E-4 3.374E-3 20 483
26 TTTGCAC,MIR-19A:MSigDB TTTGCAC,MIR-19A:MSigDB MSigDB 2.434E-6 1.249E-4 9.761E-4 3.374E-3 20 483
27 hsa-miR-152:PITA hsa-miR-152:PITA TOP PITA 2.434E-6 1.249E-4 9.761E-4 3.374E-3 20 483
28 miR-367:PicTar miR-367:PicTar PicTar 4.473E-6 2.176E-4 1.700E-3 6.200E-3 16 336
29 AACTGGA,MIR-145:MSigDB AACTGGA,MIR-145:MSigDB MSigDB 4.553E-6 2.176E-4 1.700E-3 6.311E-3 13 225
30 hsa-miR-216b:PITA hsa-miR-216b:PITA TOP PITA 4.823E-6 2.228E-4 1.741E-3 6.685E-3 16 338
31 TGGTGCT,MIR-29B:MSigDB TGGTGCT,MIR-29B:MSigDB MSigDB 8.328E-6 3.498E-4 2.732E-3 1.154E-2 19 480
32 TGGTGCT,MIR-29A:MSigDB TGGTGCT,MIR-29A:MSigDB MSigDB 8.328E-6 3.498E-4 2.732E-3 1.154E-2 19 480
33 TGGTGCT,MIR-29C:MSigDB TGGTGCT,MIR-29C:MSigDB MSigDB 8.328E-6 3.498E-4 2.732E-3 1.154E-2 19 480
34 hsa-miR-624:PITA hsa-miR-624:PITA TOP PITA 8.774E-6 3.577E-4 2.794E-3 1.216E-2 14 276
35 hsa-miR-193b:TargetScan hsa-miR-193b:TargetScan TargetScan 1.056E-5 4.066E-4 3.176E-3 1.464E-2 10 142
36 hsa-miR-193a-3p:TargetScan hsa-miR-193a-3p:TargetScan TargetScan 1.056E-5 4.066E-4 3.176E-3 1.464E-2 10 142
37 miR-145:PicTar miR-145:PicTar PicTar 1.246E-5 4.625E-4 3.613E-3 1.727E-2 13 247
38 miR-132:PicTar miR-132:PicTar PicTar 1.308E-5 4.625E-4 3.613E-3 1.813E-2 12 212
39 miR-212:PicTar miR-212:PicTar PicTar 1.308E-5 4.625E-4 3.613E-3 1.813E-2 12 212
40 hsa-miR-520f:PITA hsa-miR-520f:PITA TOP PITA 1.335E-5 4.625E-4 3.613E-3 1.850E-2 18 452
41 hsa-miR-582-3p:PITA hsa-miR-582-3p:PITA TOP PITA 1.976E-5 6.463E-4 5.049E-3 2.739E-2 13 258
42 miR-200b:PicTar miR-200b:PicTar PicTar 2.005E-5 6.463E-4 5.049E-3 2.779E-2 18 466
43 miR-200c:PicTar miR-200c:PicTar PicTar 2.063E-5 6.463E-4 5.049E-3 2.859E-2 18 467
44 hsa-miR-376c:PITA hsa-miR-376c:PITA TOP PITA 2.074E-5 6.463E-4 5.049E-3 2.874E-2 14 298
45 GACTGTT,MIR-132:MSigDB GACTGTT,MIR-132:MSigDB MSigDB 2.145E-5 6.463E-4 5.049E-3 2.973E-2 10 154
46 GACTGTT,MIR-212:MSigDB GACTGTT,MIR-212:MSigDB MSigDB 2.145E-5 6.463E-4 5.049E-3 2.973E-2 10 154
47 hsa-miR-105:PITA hsa-miR-105:PITA TOP PITA 2.787E-5 8.217E-4 6.419E-3 3.862E-2 17 433
48 miR-32:PicTar miR-32:PicTar PicTar 3.817E-5 1.096E-3 8.563E-3
5.291E-2
 17 444
49 hsa-miR-641:PITA hsa-miR-641:PITA TOP PITA 3.875E-5 1.096E-3 8.563E-3
5.371E-2
 18 490
50 hsa-miR-1304:PITA hsa-miR-1304:PITA TOP PITA 4.260E-5 1.181E-3 9.224E-3
5.904E-2
 9 134
Show 45 more annotations

17: Drug [Display Chart] 25760 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000104802 Rgd Peptide Stitch 2.011E-18 5.180E-14 5.560E-13 5.180E-14 26 239
2 CID000024766 chondroitin sulfate Stitch 2.766E-15 3.563E-11 3.824E-10 7.126E-11 29 413
3 2881 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.462E-14 1.165E-10 1.250E-9 3.767E-10 20 181
4 7084 UP MS-275; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 1.809E-14 1.165E-10 1.250E-9 4.660E-10 20 183
5 C013186 2,3-pentanedione CTD 5.226E-14 2.471E-10 2.652E-9 1.346E-9 17 126
6 D010656 Phenylephrine CTD 5.756E-14 2.471E-10 2.652E-9 1.483E-9 30 500
7 3243 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 9.404E-14 3.461E-10 3.714E-9 2.422E-9 19 175
8 C487081 belinostat CTD 1.877E-13 6.044E-10 6.488E-9 4.835E-9 27 417
9 7074 UP MS-275; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 2.350E-13 6.727E-10 7.221E-9 6.054E-9 19 184
10 D017258 Medroxyprogesterone Acetate CTD 2.758E-13 7.104E-10 7.625E-9 7.104E-9 26 390
11 5018 UP Metixene hydrochloride [1553-34-0]; Up 200; 11.6uM; MCF7; HT HG-U133A Broad Institute CMAP 3.197E-13 7.486E-10 8.036E-9 8.235E-9 18 163
12 979 UP ionomycin calcium salt; Up 200; 2uM; MCF7; HT HG-U133A EA Broad Institute CMAP 3.952E-13 8.484E-10 9.107E-9 1.018E-8 18 165
13 C577942 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide CTD 8.443E-13 1.673E-9 1.796E-8 2.175E-8 10 31
14 1068 UP thioridazine hydrochloride; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.657E-12 2.962E-9 3.179E-8 4.268E-8 17 155
15 5590 UP thioridazine hydrochloride; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.775E-12 2.962E-9 3.179E-8 4.572E-8 18 180
16 D010938 Plant Oils CTD 1.839E-12 2.962E-9 3.179E-8 4.738E-8 28 496
17 C488369 dasatinib CTD 3.461E-12 5.244E-9 5.629E-8 8.915E-8 27 472
18 D000069439 Dasatinib CTD 3.817E-12 5.463E-9 5.864E-8 9.834E-8 27 474
19 CID000030956 AC1L1KMJ Stitch 4.208E-12 5.706E-9 6.125E-8 1.084E-7 27 476
20 3232 UP Mitoxantrone dihydrochloride [70476-82-3]; Up 200; 7.8uM; MCF7; HT HG-U133A Broad Institute CMAP 4.467E-12 5.753E-9 6.175E-8 1.151E-7 18 190
21 D003609 Dactinomycin CTD 7.434E-12 8.749E-9 9.391E-8 1.915E-7 21 282
22 6051 UP Lycorine hydrochloride [2188-68-3]; Up 200; 12.4uM; MCF7; HT HG-U133A Broad Institute CMAP 7.472E-12 8.749E-9 9.391E-8 1.925E-7 17 170
23 6823 UP Terfenadine [50679-08-8]; Up 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.433E-11 1.605E-8 1.722E-7 3.691E-7 16 152
24 C506614 PD 0325901 CTD 1.621E-11 1.637E-8 1.758E-7 4.175E-7 14 108
25 1891 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HG-U133A Broad Institute CMAP 1.716E-11 1.637E-8 1.758E-7 4.421E-7 17 179
26 4554 DN Withaferin A [5119-48-2]; Down 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 1.716E-11 1.637E-8 1.758E-7 4.421E-7 17 179
27 2794 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.716E-11 1.637E-8 1.758E-7 4.421E-7 17 179
28 7356 UP Zuclopenthixol hydrochloride [633-59-0]; Up 200; 9.2uM; MCF7; HT HG-U133A Broad Institute CMAP 1.877E-11 1.667E-8 1.789E-7 4.835E-7 17 180
29 5484 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.877E-11 1.667E-8 1.789E-7 4.835E-7 17 180
30 3227 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 2.240E-11 1.924E-8 2.065E-7 5.771E-7 17 182
31 2651 UP Suloctidil [54063-56-8]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP 2.352E-11 1.955E-8 2.098E-7 6.059E-7 16 157
32 C008493 methylselenic acid CTD 3.147E-11 2.533E-8 2.719E-7 8.107E-7 24 407
33 D016685 Mitomycin CTD 3.311E-11 2.585E-8 2.774E-7 8.530E-7 24 408
34 2658 UP Anisomycin [22862-76-6]; Up 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 3.793E-11 2.873E-8 3.084E-7 9.770E-7 16 162
35 6954 UP fluphenazine dihydrochloride; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 4.092E-11 3.011E-8 3.232E-7 1.054E-6 17 189
36 CID000003961 losartan Stitch 4.429E-11 3.169E-8 3.402E-7 1.141E-6 23 378
37 7188 UP Fendiline hydrochloride [13636-18-5]; Up 200; 11.4uM; MCF7; HT HG-U133A Broad Institute CMAP 4.570E-11 3.181E-8 3.415E-7 1.177E-6 16 164
38 5212 UP prochlorperazine dimaleate salt; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 6.014E-11 4.077E-8 4.376E-7 1.549E-6 16 167
39 5310 UP Puromycin dihydrochloride [58-58-2]; Up 200; 7.4uM; MCF7; HT HG-U133A Broad Institute CMAP 6.582E-11 4.320E-8 4.637E-7 1.695E-6 16 168
40 C568713 GSK1210151A CTD 6.708E-11 4.320E-8 4.637E-7 1.728E-6 10 46
41 6171 UP Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP 7.284E-11 4.577E-8 4.913E-7 1.876E-6 17 196
42 965 UP felodipine; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 7.869E-11 4.826E-8 5.181E-7 2.027E-6 16 170
43 D019808 Losartan CTD 8.106E-11 4.856E-8 5.212E-7 2.088E-6 15 145
44 3318 UP Hexetidine [141-94-6]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP 8.597E-11 4.974E-8 5.339E-7 2.215E-6 16 171
45 D015056 1-Methyl-3-isobutylxanthine CTD 8.689E-11 4.974E-8 5.339E-7 2.238E-6 23 391
46 6989 UP thioridazine hydrochloride; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 9.386E-11 5.144E-8 5.522E-7 2.418E-6 16 172
47 906 UP calmidazolium chloride; Up 200; 5uM; MCF7; HT HG-U133A EA Broad Institute CMAP 9.386E-11 5.144E-8 5.522E-7 2.418E-6 16 172
48 7285 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.024E-10 5.496E-8 5.900E-7 2.638E-6 16 173
49 3295 UP Felodipine [72509-76-3]; Up 200; 10.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.217E-10 6.271E-8 6.731E-7 3.136E-6 16 175
50 909 UP HC toxin from Helminthosporium carbonum; Up 200; 0.1uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.217E-10 6.271E-8 6.731E-7 3.136E-6 16 175
Show 45 more annotations

18: Disease [Display Chart] 2920 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0042373 Vascular Diseases DisGeNET Curated 6.448E-10 1.009E-6 8.633E-6 1.883E-6 23 346
2 umls:C0034069 Pulmonary Fibrosis DisGeNET Curated 6.910E-10 1.009E-6 8.633E-6 2.018E-6 22 317
3 umls:C0013720 Ehlers-Danlos Syndrome DisGeNET Curated 3.829E-8 3.727E-5 3.189E-4 1.118E-4 9 52
4 umls:C1519670 Tumor Angiogenesis DisGeNET BeFree 6.801E-8 4.965E-5 4.248E-4 1.986E-4 23 443
5 umls:C1800706 Idiopathic Pulmonary Fibrosis DisGeNET Curated 1.477E-7 8.628E-5 7.382E-4 4.314E-4 19 323
6 umls:C0278488 Carcinoma breast stage IV DisGeNET BeFree 3.412E-7 1.661E-4 1.421E-3 9.964E-4 19 341
7 umls:C0002940 Aneurysm DisGeNET Curated 4.285E-7 1.788E-4 1.530E-3 1.251E-3 12 135
8 umls:C2733158 Cerebral Small Vessel Diseases DisGeNET BeFree 6.031E-7 2.201E-4 1.883E-3 1.761E-3 5 13
9 umls:C0239946 Fibrosis, Liver DisGeNET BeFree 8.383E-7 2.720E-4 2.327E-3 2.448E-3 18 327
10 umls:C0278883 Metastatic melanoma DisGeNET BeFree 1.089E-6 3.181E-4 2.722E-3 3.181E-3 18 333
11 umls:C0016057 Fibrosarcoma DisGeNET Curated 1.567E-6 4.159E-4 3.559E-3 4.575E-3 15 241
12 umls:C0917798 Cerebral Ischemia DisGeNET BeFree 2.638E-6 6.420E-4 5.494E-3 7.704E-3 13 189
13 umls:C0030297 Pancreatic Neoplasm DisGeNET Curated 2.959E-6 6.647E-4 5.687E-3 8.641E-3 19 394
14 umls:C0011644 Scleroderma DisGeNET BeFree 3.854E-6 8.038E-4 6.878E-3 1.125E-2 12 166
15 umls:C0278996 Cancer of Head and Neck DisGeNET BeFree 4.572E-6 8.469E-4 7.247E-3 1.335E-2 19 406
16 umls:C0853879 Invasive breast carcinoma DisGeNET BeFree 4.641E-6 8.469E-4 7.247E-3 1.355E-2 18 369
17 umls:C0007785 Cerebral Infarction DisGeNET Curated 5.043E-6 8.562E-4 7.326E-3 1.473E-2 15 265
18 umls:C0236969 Substance-Related Disorders DisGeNET Curated 5.278E-6 8.562E-4 7.326E-3 1.541E-2 10 116
19 umls:C0494165 Secondary malignant neoplasm of liver DisGeNET BeFree 5.894E-6 9.058E-4 7.751E-3 1.721E-2 20 452
20 umls:C0268731 Renal glomerular disease DisGeNET BeFree 6.655E-6 9.717E-4 8.315E-3 1.943E-2 9 94
21 umls:C0340643 Dissection of aorta DisGeNET BeFree 8.124E-6 1.091E-3 9.336E-3 2.372E-2 6 35
22 umls:C0032927 Precancerous Conditions DisGeNET Curated 8.221E-6 1.091E-3 9.336E-3 2.400E-2 19 423
23 umls:C1568272 Tendinopathy DisGeNET BeFree 8.702E-6 1.105E-3 9.453E-3 2.541E-2 5 21
24 umls:C0027626 Neoplasm Invasiveness DisGeNET Curated 1.662E-5 2.022E-3 1.730E-2 4.854E-2 10 132
25 umls:C0948008 Ischemic stroke DisGeNET Curated 1.867E-5 2.181E-3 1.866E-2
5.453E-2
 17 370
26 umls:C0033999 Pterygium DisGeNET Curated 2.199E-5 2.457E-3 2.102E-2
6.420E-2
 7 61
27 umls:C0008497 Choriocarcinoma DisGeNET BeFree 2.272E-5 2.457E-3 2.102E-2
6.634E-2
 14 265
28 umls:C0023893 Liver Cirrhosis, Experimental DisGeNET Curated 2.395E-5 2.497E-3 2.137E-2
6.992E-2
 9 110
29 umls:C0042345 Varicosity DisGeNET Curated 2.779E-5 2.798E-3 2.394E-2
8.115E-2
 6 43
30 umls:C0025286 Meningioma DisGeNET Curated 2.898E-5 2.820E-3 2.413E-2
8.461E-2
 17 383
31 umls:C2697932 Loeys-Dietz Syndrome DisGeNET Curated 3.348E-5 3.154E-3 2.699E-2
9.777E-2
 4 14
32 umls:C2936349 Plaque, Amyloid DisGeNET Curated 3.579E-5 3.167E-3 2.710E-2
1.045E-1
 12 207
33 umls:C0003486 Aortic Aneurysm DisGeNET Curated 3.579E-5 3.167E-3 2.710E-2
1.045E-1
 12 207
34 umls:C1561643 Chronic Kidney Diseases DisGeNET Curated 4.855E-5 4.117E-3 3.523E-2
1.418E-1
 14 284
35 umls:C0575158 Kyphoscoliosis deformity of spine DisGeNET BeFree 5.243E-5 4.117E-3 3.523E-2
1.531E-1
 3 6
36 umls:C0600033 Acquired Kyphoscoliosis DisGeNET BeFree 5.243E-5 4.117E-3 3.523E-2
1.531E-1
 3 6
37 umls:C0345392 Congenital kyphoscoliosis DisGeNET BeFree 5.243E-5 4.117E-3 3.523E-2
1.531E-1
 3 6
38 umls:C0026850 Muscular Dystrophy DisGeNET Curated 5.416E-5 4.117E-3 3.523E-2
1.582E-1
 12 216
39 umls:C0010072 Coronary Thrombosis DisGeNET Curated 5.499E-5 4.117E-3 3.523E-2
1.606E-1
 5 30
40 umls:C0038356 Stomach Neoplasms DisGeNET Curated 6.212E-5 4.535E-3 3.880E-2
1.814E-1
 19 490
41 umls:C1704272 Benign Prostatic Hyperplasia DisGeNET BeFree 7.478E-5 5.326E-3 4.557E-2
2.184E-1
 16 373
42 umls:C0007112 Adenocarcinoma of prostate DisGeNET BeFree 8.182E-5 5.688E-3 4.867E-2
2.389E-1
 10 159
43 umls:C0009782 Connective Tissue Diseases DisGeNET Curated 8.476E-5 5.720E-3 4.894E-2
2.475E-1
 7 75
44 umls:C3272363 Ischemic Cerebrovascular Accident DisGeNET Curated 8.619E-5 5.720E-3 4.894E-2
2.517E-1
 15 338
45 umls:C0158266 Intervertebral Disc Degeneration DisGeNET Curated 9.226E-5 5.986E-3
5.122E-2
2.694E-1
 7 76
46 umls:C0346957 Disseminated Malignant Neoplasm DisGeNET BeFree 9.563E-5 6.071E-3
5.195E-2
2.793E-1
 10 162
47 umls:C0024031 Low Back Pain DisGeNET Curated 9.794E-5 6.083E-3
5.205E-2
2.860E-1
 4 18
48 umls:C0878500 Intraepithelial Neoplasia DisGeNET BeFree 1.003E-4 6.083E-3
5.205E-2
2.930E-1
 9 132
49 umls:C0341858 Endometriosis of uterus DisGeNET BeFree 1.036E-4 6.083E-3
5.205E-2
3.025E-1
 6 54
50 umls:C0029456 Osteoporosis DisGeNET Curated 1.042E-4 6.083E-3
5.205E-2
3.041E-1
 14 305
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