Toppgene analysis for aggregated_1964_log, IC30, negative side

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1: GO: Molecular Function [Display Chart] 437 annotations before applied cutoff / 18819 genes in category

No results to display

2: GO: Biological Process [Display Chart] 2232 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0060538 skeletal muscle organ development 2.807E-6 6.265E-3
5.193E-2
 6.265E-3 8 202
2 GO:0007519 skeletal muscle tissue development 2.079E-5 2.320E-2
1.923E-1
 4.640E-2 7 192
3 GO:0046683 response to organophosphorus 4.284E-5 3.133E-2
2.597E-1
9.561E-2
 6 146
4 GO:0014706 striated muscle tissue development 6.232E-5 3.133E-2
2.597E-1
1.391E-1
 9 401
5 GO:0007517 muscle organ development 7.388E-5 3.133E-2
2.597E-1
1.649E-1
 9 410
6 GO:0060537 muscle tissue development 8.719E-5 3.133E-2
2.597E-1
1.946E-1
 9 419
7 GO:0034599 cellular response to oxidative stress 1.026E-4 3.133E-2
2.597E-1
2.289E-1
 7 247
8 GO:0006982 response to lipid hydroperoxide 1.123E-4 3.133E-2
2.597E-1
2.507E-1
 2 4
9 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 1.331E-4 3.301E-2
2.736E-1
2.971E-1
 8 346
Show 4 more annotations

3: GO: Cellular Component [Display Chart] 209 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005578 proteinaceous extracellular matrix 5.459E-6 1.141E-3 6.756E-3 1.141E-3 10 379
2 GO:0031012 extracellular matrix 2.156E-5 2.253E-3 1.334E-2 4.506E-3 10 444
3 GO:0044420 extracellular matrix component 3.917E-4 2.729E-2
1.616E-1
8.187E-2
 5 143

4: Human Phenotype [Display Chart] 421 annotations before applied cutoff / 4410 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 1948 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000550 abnormal forelimb morphology 1.649E-5 1.797E-2
1.465E-1
 3.213E-2 8 206
2 MP:0002100 abnormal tooth morphology 2.325E-5 1.797E-2
1.465E-1
 4.528E-2 8 216
3 MP:0000454 abnormal jaw morphology 2.767E-5 1.797E-2
1.465E-1
5.391E-2
 11 446
4 MP:0005504 abnormal ligament morphology 6.848E-5 3.335E-2
2.719E-1
1.334E-1
 4 40
5 MP:0000443 abnormal snout morphology 9.948E-5 3.559E-2
2.902E-1
1.938E-1
 7 196
6 MP:0000167 decreased chondrocyte number 1.758E-4 3.559E-2
2.902E-1
3.425E-1
 3 20
7 MP:0005421 loose skin 1.758E-4 3.559E-2
2.902E-1
3.425E-1
 3 20
8 MP:0000552 abnormal radius morphology 1.780E-4 3.559E-2
2.902E-1
3.467E-1
 5 95
9 MP:0006343 enlarged first pharyngeal arch 1.827E-4 3.559E-2
2.902E-1
3.559E-1
 2 4
10 MP:0000619 salivary gland epithelial hyperplasia 1.827E-4 3.559E-2
2.902E-1
3.559E-1
 2 4
11 MP:0005358 abnormal incisor morphology 2.600E-4 4.605E-2
3.754E-1
5.066E-1
 5 103
Show 6 more annotations

6: Domain [Display Chart] 637 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR013273 Peptidase M12B ADAM-TS InterPro 1.644E-4 3.719E-2
2.616E-1
1.047E-1
 3 24
2 IPR026823 cEGF InterPro 2.098E-4 3.719E-2
2.616E-1
1.337E-1
 3 26
3 PF12662 cEGF Pfam 2.098E-4 3.719E-2
2.616E-1
1.337E-1
 3 26
4 PF00683 TB Pfam 4.111E-4 3.719E-2
2.616E-1
2.619E-1
 2 7
5 3.90.290.10 - Gene3D 5.465E-4 3.719E-2
2.616E-1
3.481E-1
 2 8
6 PF07645 EGF CA Pfam 6.038E-4 3.719E-2
2.616E-1
3.846E-1
 4 86
7 SM00181 EGF SMART 6.718E-4 3.719E-2
2.616E-1
4.280E-1
 6 236
8 IPR009030 Growth fac rcpt InterPro 6.826E-4 3.719E-2
2.616E-1
4.348E-1
 5 156
9 PS51364 TB PROSITE 7.006E-4 3.719E-2
2.616E-1
4.463E-1
 2 9
10 PF07002 Copine Pfam 7.006E-4 3.719E-2
2.616E-1
4.463E-1
 2 9
11 IPR017878 TB dom InterPro 7.006E-4 3.719E-2
2.616E-1
4.463E-1
 2 9
12 IPR010734 Copine InterPro 7.006E-4 3.719E-2
2.616E-1
4.463E-1
 2 9
13 IPR000742 EGF-like dom InterPro 9.067E-4 3.962E-2
2.787E-1
5.775E-1
 6 250
14 IPR018097 EGF Ca-bd CS InterPro 9.490E-4 3.962E-2
2.787E-1
6.045E-1
 4 97
15 PS01187 EGF CA PROSITE 1.024E-3 3.962E-2
2.787E-1
6.524E-1
 4 99
16 PS00022 EGF 1 PROSITE 1.025E-3 3.962E-2
2.787E-1
6.528E-1
 6 256
17 PS00010 ASX HYDROXYL PROSITE 1.063E-3 3.962E-2
2.787E-1
6.772E-1
 4 100
18 PS01186 EGF 2 PROSITE 1.248E-3 3.962E-2
2.787E-1
7.947E-1
 6 266
19 IPR000152 EGF-type Asp/Asn hydroxyl site InterPro 1.320E-3 3.962E-2
2.787E-1
8.407E-1
 4 106
20 PS00203 METALLOTHIONEIN VRT PROSITE 1.500E-3 3.962E-2
2.787E-1
9.558E-1
 2 13
21 IPR003019 Metalthion InterPro 1.745E-3 3.962E-2
2.787E-1
1.000E0
 2 14
22 IPR000006 Metalthion vert InterPro 1.745E-3 3.962E-2
2.787E-1
1.000E0
 2 14
23 PF08686 PLAC Pfam 1.745E-3 3.962E-2
2.787E-1
1.000E0
 2 14
24 PF00131 Metallothio Pfam 1.745E-3 3.962E-2
2.787E-1
1.000E0
 2 14
25 SM00179 EGF CA SMART 2.211E-3 3.962E-2
2.787E-1
1.000E0
 4 122
26 IPR001881 EGF-like Ca-bd dom InterPro 2.345E-3 3.962E-2
2.787E-1
1.000E0
 4 124
27 PF07974 EGF 2 Pfam 2.475E-3 3.962E-2
2.787E-1
1.000E0
 3 60
28 IPR013111 EGF extracell InterPro 2.475E-3 3.962E-2
2.787E-1
1.000E0
 3 60
29 PF00090 TSP 1 Pfam 2.844E-3 3.962E-2
2.787E-1
1.000E0
 3 63
30 PS50092 TSP1 PROSITE 3.109E-3 3.962E-2
2.787E-1
1.000E0
 3 65
31 SM00209 TSP1 SMART 3.109E-3 3.962E-2
2.787E-1
1.000E0
 3 65
32 IPR000884 TSP1 rpt InterPro 3.109E-3 3.962E-2
2.787E-1
1.000E0
 3 65
33 IPR010909 PLAC InterPro 3.233E-3 3.962E-2
2.787E-1
1.000E0
 2 19
34 PS50900 PLAC PROSITE 3.233E-3 3.962E-2
2.787E-1
1.000E0
 2 19
35 PS50026 EGF 3 PROSITE 4.187E-3 3.962E-2
2.787E-1
1.000E0
 5 236
36 PF11914 DUF3432 Pfam 4.484E-3 3.962E-2
2.787E-1
1.000E0
 1 1
37 IPR032969 DHRS3 InterPro 4.484E-3 3.962E-2
2.787E-1
1.000E0
 1 1
38 IPR001103 Andrgn rcpt InterPro 4.484E-3 3.962E-2
2.787E-1
1.000E0
 1 1
39 IPR022327 IGFBP-4 InterPro 4.484E-3 3.962E-2
2.787E-1
1.000E0
 1 1
40 PF00764 Arginosuc synth Pfam 4.484E-3 3.962E-2
2.787E-1
1.000E0
 1 1
41 IPR007455 Serglycin InterPro 4.484E-3 3.962E-2
2.787E-1
1.000E0
 1 1
42 IPR002987 NaCa exhngr1 InterPro 4.484E-3 3.962E-2
2.787E-1
1.000E0
 1 1
43 PS00564 ARGININOSUCCIN SYN 1 PROSITE 4.484E-3 3.962E-2
2.787E-1
1.000E0
 1 1
44 PF02166 Androgen recep Pfam 4.484E-3 3.962E-2
2.787E-1
1.000E0
 1 1
45 IPR002211 Lymphspecific InterPro 4.484E-3 3.962E-2
2.787E-1
1.000E0
 1 1
46 IPR021839 DUF3432 InterPro 4.484E-3 3.962E-2
2.787E-1
1.000E0
 1 1
47 2.40.128.80 - Gene3D 4.484E-3 3.962E-2
2.787E-1
1.000E0
 1 1
48 IPR013576 IGF2 C InterPro 4.484E-3 3.962E-2
2.787E-1
1.000E0
 1 1
49 IPR027070 Integrin b-like p1 InterPro 4.484E-3 3.962E-2
2.787E-1
1.000E0
 1 1
50 IPR031216 Noelin-3 InterPro 4.484E-3 3.962E-2
2.787E-1
1.000E0
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 502 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 730311 Molecules associated with elastic fibres BioSystems: REACTOME 1.774E-5 8.905E-3
6.053E-2
 8.905E-3 4 30
2 730310 Elastic fibre formation BioSystems: REACTOME 6.276E-5 1.575E-2
1.071E-1
 3.151E-2 4 41
3 712094 Cardiac Progenitor Differentiation BioSystems: WikiPathways 1.731E-4 2.896E-2
1.968E-1
8.688E-2
 4 53

8: Pubmed [Display Chart] 15166 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20551380 Proteomics characterization of extracellular space components in the human aorta. Pubmed 2.237E-8 3.393E-4 3.462E-3 3.393E-4 6 101
2 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 3.164E-7 1.578E-3 1.610E-2 4.798E-3 8 383
3 19453261:gr High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. GeneRIF 3.164E-7 1.578E-3 1.610E-2 4.798E-3 8 383
4 20546612:gr The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. GeneRIF 5.201E-7 1.578E-3 1.610E-2 7.888E-3 5 91
5 20546612 The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. Pubmed 5.201E-7 1.578E-3 1.610E-2 7.888E-3 5 91
6 16210365:gr Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element. GeneRIF 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
7 22537775:gr Hippocampal c-Fos activation in normal and LPA¿-null mice after two object recognition tasks with different memory demands. GeneRIF 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
8 22295116:gr Genome-wide association study of copy number variants suggests LTBP1 and FGD4 are important for alcohol drinking. GeneRIF 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
9 25858550 Latent transforming growth factor-¿ binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization. Pubmed 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
10 23439698:gr Gonadal- and sex-chromosome-dependent sex differences in the circadian system. GeneRIF 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
11 12890669 Early growth response gene 1 modulates androgen receptor signaling in prostate carcinoma cells. Pubmed 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
12 26467701 Androgen Receptor and Androgen-Responsive Gene FKBP5 Are Independent Prognostic Indicators for Esophageal Adenocarcinoma. Pubmed 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
13 20406487:gr Anxiety- and depressive-like responses and c-fos activity in preproenkephalin knockout mice: oversensitivity hypothesis of enkephalin deficit-induced posttraumatic stress disorder. GeneRIF 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
14 11813242:gr Immediate-early gene response to methamphetamine, haloperidol, and quinolinic acid is not impaired in Huntington's disease transgenic mice. GeneRIF 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
15 17888402:gr Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3. GeneRIF 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
16 19862539:gr Differential expression of fibulins in the uterosacral ligaments of women with uterine prolapse. GeneRIF 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
17 18258685:gr Insulin-like growth factor (IGF) binding protein-4 is both a positive and negative regulator of IGF activity in vivo. GeneRIF 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
18 22295116 Genome-wide association study of copy number variants suggests LTBP1 and FGD4 are important for alcohol drinking. Pubmed 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
19 12890669:gr Early growth response gene 1 modulates androgen receptor signaling in prostate carcinoma cells. GeneRIF 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
20 17581631:gr Latent TGF-beta-binding protein 2 binds to DANCE/fibulin-5 and regulates elastic fiber assembly. GeneRIF 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
21 21655193:gr A fear-inducing odor alters PER2 and c-Fos expression in brain regions involved in fear memory. GeneRIF 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
22 23877345 From AR to c-Met: androgen deprivation leads to a signaling pathway switch in prostate cancer cells. Pubmed 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
23 19862539 Differential expression of fibulins in the uterosacral ligaments of women with uterine prolapse. Pubmed 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
24 19433454:gr Decorin is a novel antagonistic ligand of the Met receptor. GeneRIF 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
25 25460502 Transcriptomic profiling of taxol-resistant ovarian cancer cells identifies FKBP5 and the androgen receptor as critical markers of chemotherapeutic response. Pubmed 2.847E-6 1.727E-3 1.763E-2 4.319E-2 2 2
26 25429064 Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Pubmed 3.791E-6 2.212E-3 2.257E-2
5.750E-2
 5 136
27 18391951 Many sequence variants affecting diversity of adult human height. Pubmed 4.845E-6 2.588E-3 2.641E-2
7.349E-2
 5 143
28 23079385 The production and regulation of IGF and IGFBPs in human adipose tissue cultures. Pubmed 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
29 24148803 LTBP-2 competes with tropoelastin for binding to fibulin-5 and heparin, and is a negative modulator of elastinogenesis. Pubmed 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
30 23365660:gr Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration. GeneRIF 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
31 17142810:gr Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology. GeneRIF 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
32 14966901 Expression of Egr-1, c-fos and cyclin D1 in esophageal cancer and its precursors: An immunohistochemical and in situ hybridization study. Pubmed 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
33 22659570:gr LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis. GeneRIF 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
34 14966901:gr Expression of Egr-1, c-fos and cyclin D1 in esophageal cancer and its precursors: An immunohistochemical and in situ hybridization study. GeneRIF 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
35 23782690 Fibulin-3, -4, and -5 are highly susceptible to proteolysis, interact with cells and heparin, and form multimers. Pubmed 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
36 21920606:gr c-Jun and c-Fos regulate the complement factor H promoter in murine astrocytes. GeneRIF 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
37 20048054 FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells. Pubmed 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
38 20048054:gr FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells. GeneRIF 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
39 25953903 Coupling of Conformational Transitions in the N-terminal Domain of the 51-kDa FK506-binding Protein (FKBP51) Near Its Site of Interaction with the Steroid Receptor Proteins. Pubmed 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
40 22659570 LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis. Pubmed 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
41 7680905 Anatomy of the human ovarian insulin-like growth factor system. Pubmed 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
42 23365660 Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration. Pubmed 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
43 15721299:gr Plasminogen/plasmin regulates c-fos and egr-1 expression via the MEK/ERK pathway. GeneRIF 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
44 22354777 Phosphorylation of histone H3 at serine 10 has an essential role in arsenite-induced expression of FOS, EGR1 and IL8 mRNA in cultured human cell lines. Pubmed 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
45 9722589 Structure-function analysis of the human insulin-like growth factor binding protein-4. Pubmed 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
46 17520086:gr Androgen receptor and c-Myc transcription factors as putative partners in the in vivo cross-talk between androgen receptor-mediated and c-Met-mediated signalling pathways. GeneRIF 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
47 21497182:gr Induction of c-Fos, Zif268, and Arc from acute bouts of voluntary wheel running in new and pre-existing adult mouse hippocampal granule neurons. GeneRIF 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
48 23079385:gr The production and regulation of IGF and IGFBPs in human adipose tissue cultures. GeneRIF 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
49 17293099:gr LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein. GeneRIF 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
50 17293099 LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein. Pubmed 8.533E-6 2.588E-3 2.641E-2
1.294E-1
 2 3
Show 45 more annotations

9: Interaction [Display Chart] 1835 annotations before applied cutoff / 16534 genes in category

No results to display

10: Cytoband [Display Chart] 82 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1p11.1 1p11.1 2.510E-3 4.568E-2
2.280E-1
2.058E-1
 1 1
2 12q22-q23.1 12q22-q23.1 2.510E-3 4.568E-2
2.280E-1
2.058E-1
 1 1
3 16q13 16q13 3.918E-3 4.568E-2
2.280E-1
3.212E-1
 2 37
4 11p15.5 11p15.5 4.069E-3 4.568E-2
2.280E-1
3.337E-1
 3 127
5 12p12.3-p12.1 12p12.3-p12.1 5.014E-3 4.568E-2
2.280E-1
4.111E-1
 1 2
6 2p23-p22 2p23-p22 5.014E-3 4.568E-2
2.280E-1
4.111E-1
 1 2
7 13q14.1 13q14.1 5.014E-3 4.568E-2
2.280E-1
4.111E-1
 1 2
8 4q28-q32 4q28-q32 5.014E-3 4.568E-2
2.280E-1
4.111E-1
 1 2
9 22q11.2-q12.1 22q11.2-q12.1 5.014E-3 4.568E-2
2.280E-1
4.111E-1
 1 2
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 371 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 65 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 628 Latent transforming growth factor beta binding proteins genenames.org 6.825E-5 4.437E-3 2.111E-2 4.437E-3 2 4
2 556 Fibulins genenames.org 3.157E-4 8.776E-3 4.177E-2 2.052E-2 2 8
3 829 Copines genenames.org 4.050E-4 8.776E-3 4.177E-2 2.633E-2 2 9
4 50 ADAM metallopeptidases with thrombospondin type 1 motif genenames.org 1.882E-3 2.447E-2
1.165E-1
1.223E-1
 2 19
5 638 Metallothioneins genenames.org 1.882E-3 2.447E-2
1.165E-1
1.223E-1
 2 19

13: Coexpression [Display Chart] 5021 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13867 Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.327E-14 3.679E-10 3.347E-9 3.679E-10 15 256
2 M2001 Genes associated with migration rate of 40 human bladder cancer cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.568E-10 3.938E-7 3.583E-6 7.875E-7 11 184
3 M19391 Genes down-regulated in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.566E-10 9.316E-7 8.477E-6 2.795E-6 15 480
4 M2128 Genes up-regulated in growing IMR90 cells (fibroblast) after knockdown of RB1 [GeneID=5925] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.990E-9 3.754E-6 3.415E-5 1.501E-5 11 243
5 M4680 Genes up-regulated in RD cells (embryonal rhabdomyosarcoma, ERMS) by expression of PAX3- or PAX7-FOXO1 [GeneID=5077;5081;2308] fusions off retroviral vectors. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.946E-9 4.967E-6 4.519E-5 2.483E-5 11 255
6 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.054E-9 5.066E-6 4.609E-5 3.039E-5 11 260
7 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.132E-8 8.118E-6 7.386E-5 5.682E-5 13 425
8 M1459 Genes up-regulated in BEC (blood endothelial cells) compared to LEC (lymphatic endothelial cells). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.519E-8 9.532E-6 8.673E-5 7.626E-5 9 162
9 M17471 Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS, non-invasive). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.303E-7 7.268E-5 6.613E-4 6.541E-4 11 351
10 M2122 Genes correlated with mesenchymal type of glioblastoma multiforme tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.804E-7 9.058E-5 8.242E-4 9.058E-4 9 216
11 M4785 Genes down-regulated in monocyte-derived dendritic cells (MDDC) after stimulation with galecin-1 (lectin, LGALS1) [GeneID=3956] compared to that with bacterial lipopolysaccharide (LPS). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.609E-7 1.191E-4 1.084E-3 1.310E-3 12 463
12 M13273 Genes down-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.301E-7 1.381E-4 1.257E-3 1.657E-3 9 232
13 M8689 Top 200 marker genes down-regulated in the 'CTNNB1' subclass of hepatocellular carcinoma (HCC); characterized by activated CTNNB1 [GeneID=1499]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.585E-7 1.385E-4 1.260E-3 1.800E-3 8 170
14 M17079 Up-regulated genes distinguishing between two subtypes of gastric cancer: advanced (AGC) and early (EGC). MSigDB C2: CGP Curated Gene Sets (v5.1) 4.471E-7 1.603E-4 1.459E-3 2.245E-3 8 175
15 M2351 Genes down-regulated in leukemic progenitor cells expressing activated fusion of ESWR1 and FLI1 [GeneID=2130, 2313] compared to normal hematopoetic progenitors. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.335E-7 1.706E-4 1.553E-3 2.679E-3 10 321
16 M17951 Top 100 probe sets contrubuting to the positive side of the 1st principal component; predominantly associated with spindle cell and pleomorphic sarcoma samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.438E-7 1.706E-4 1.553E-3 2.730E-3 6 76
17 M19971 Genes up-regulated in peripheral blood mononucleocytes by HGF [GeneID=3082] compared to those regulated by CSF2RB (GM-CSF) and IL4 [GeneID=1437;3565]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.820E-7 1.719E-4 1.564E-3 2.922E-3 11 408
18 M14555 Down-regulated at any timepoint following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v5.1) 7.308E-7 2.038E-4 1.855E-3 3.669E-3 7 128
19 M12225 Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.476E-6 3.860E-4 3.512E-3 7.413E-3 8 205
20 M4065 Down-regulated at 24 h following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v5.1) 1.582E-6 3.860E-4 3.512E-3 7.942E-3 6 91
21 M5942 Genes down-regulated in response to ultraviolet (UV) radiation. MSigDB H: Hallmark Gene Sets (v5.1) 1.615E-6 3.860E-4 3.512E-3 8.107E-3 7 144
22 M2144 Genes consistently overexpressed with age, based on meta-analysis of microarray data. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.493E-6 5.689E-4 5.177E-3 1.252E-2 5 55
23 M4995 Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.079E-6 6.721E-4 6.116E-3 1.546E-2 10 390
24 M5505 Genes down-regulated in basal mammary epithelial cells compared to the luminal ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.544E-6 7.117E-4 6.475E-3 1.779E-2 5 59
25 M4991 'PAX-FKHR signature': genes up-regulated by PAX3- or PAX7-FOXO1 [GeneID=5081;5077;2308] fusion in primary alveolar rhabdomyosarcoma(ARMS) tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.544E-6 7.117E-4 6.475E-3 1.779E-2 5 59
26 GSE21360 PRIMARY VS QUATERNARY MEMORY CD8 TCELL UP Genes up-regulated in memory CD8 T cells: 1' versus 4'. MSigDB C7: Immunologic Signatures (v5.1) 5.668E-6 1.095E-3 9.959E-3 2.846E-2 7 174
27 M1784 Genes changed in U373-MG cells (malignant glioma) upon treatment with arsenic trioxide [PubChem=14888], a chemical that can cause autophagic cell death. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.122E-6 1.691E-3 1.539E-2 4.580E-2 6 123
28 M3645 Genes up-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.433E-6 1.691E-3 1.539E-2 4.736E-2 10 443
29 M6200 Genes up-regulated in polymorphonuclear leukocytes (24h): treated by heat killed HC60 cell (promyelocytic leukemia) lysate versus A. phagocytophilum infection. MSigDB C7: Immunologic Signatures (v5.1) 1.406E-5 2.017E-3 1.836E-2
7.061E-2
 7 200
30 GSE25123 IL4 VS IL4 AND ROSIGLITAZONE STIM MACROPHAGE DAY10 UP Genes up-regulated in wildtype bone marrow-derived macrophages treated with IL4 [GeneID=3565]: control versus rosiglitazone [PubChem=77999]. MSigDB C7: Immunologic Signatures (v5.1) 1.406E-5 2.017E-3 1.836E-2
7.061E-2
 7 200
31 M5748 Genes down-regulated in comparison of lymph node conventional T cells versus fat tissue conventional T cells. MSigDB C7: Immunologic Signatures (v5.1) 1.406E-5 2.017E-3 1.836E-2
7.061E-2
 7 200
32 M5474 Genes up-regulated in comparison of dendritic cells (DC) versus effector memory CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v5.1) 1.406E-5 2.017E-3 1.836E-2
7.061E-2
 7 200
33 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v5.1) 1.406E-5 2.017E-3 1.836E-2
7.061E-2
 7 200
34 M5906 Genes defining early response to estrogen. MSigDB H: Hallmark Gene Sets (v5.1) 1.406E-5 2.017E-3 1.836E-2
7.061E-2
 7 200
35 M5701 Genes down-regulated in comparsion of sfActCD4 versus ActCD4 (see Fig. 1 in the paper for details). MSigDB C7: Immunologic Signatures (v5.1) 1.406E-5 2.017E-3 1.836E-2
7.061E-2
 7 200
36 M18517 Genes changed between developmental stages of Valpha14i natural killer T lymphocyte cells (NKT). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.723E-5 2.321E-3 2.112E-2
8.652E-2
 10 475
37 M8513 Genes up-regulated in the normal-like subtype of breast cancer. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.754E-5 2.321E-3 2.112E-2
8.809E-2
 10 476
38 M2081 Genes down-regulated by TGFB1 [GeneID=7040] in MEF cells (embryonic fibroblast) via TGFB1R [GeneID=7046]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.756E-5 2.321E-3 2.112E-2
8.819E-2
 7 207
39 M15484 Genes changed in HMLE cells (mmortalized nontransformed mammary epithelium) after RNAi knockdown of both CDH1 and CTNNB1 [GeneID=999;1499], compared to the knockdown of CDH1 alone. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.909E-5 2.423E-3 2.205E-2
9.583E-2
 5 83
40 M14791 Genes down-regulated in colorectal adenoma compared to normal mucosa samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.930E-5 2.423E-3 2.205E-2
9.692E-2
 8 291
41 M2259 Partial list of genes up-regulated in the kidney of GLIS2 [GeneID=84662] knockout mice compared to the wild type. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.023E-5 2.478E-3 2.254E-2
1.016E-1
 5 84
42 M19130 Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 16 h time point that were not down-regulated at the previous time point, 14 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.268E-5 2.712E-3 2.467E-2
1.139E-1
 5 86
43 M14098 Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 24 h time point that were not down-regulated at the previous time point, 20 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.615E-5 2.989E-3 2.719E-2
1.313E-1
 6 148
44 M4872 Genes up-regulated in mature plasma cells compared with plasmablastic B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.624E-5 2.989E-3 2.719E-2
1.317E-1
 9 397
45 M215 Selected genes up-regulated in prostate tumors developed by transgenic mice overexpressing VAV3 [GeneID=10451] in prostate epithelium. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.679E-5 2.989E-3 2.719E-2
1.345E-1
 5 89
46 M18274 Genes up-regulated in uterine fibroids vs normal myometrium samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.938E-5 3.186E-3 2.899E-2
1.475E-1
 4 45
47 M2154 Genes down-regulated in MCF7 cells (breast cancer) at 6 h of estradiol [PubChemID=5757] treatment. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.983E-5 3.186E-3 2.899E-2
1.498E-1
 5 91
48 M2256 Genes commonly down-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313 ,2078]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.174E-5 3.320E-3 3.020E-2
1.593E-1
 7 227
49 M19541 Genes commonly down-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.248E-5 3.328E-3 3.028E-2
1.631E-1
 9 408
50 M2293 Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.397E-5 3.411E-3 3.104E-2
1.706E-1
 8 315
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2819 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 4.194E-18 1.182E-14 1.008E-13 1.182E-14 22 438
2 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.812E-17 2.554E-14 2.177E-13 5.109E-14 21 410
3 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 3.848E-14 2.736E-11 2.331E-10 1.085E-10 19 461
4 JC fibro 1000 K1 JC fibro top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 4.323E-14 2.736E-11 2.331E-10 1.219E-10 19 464
5 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 4.852E-14 2.736E-11 2.331E-10 1.368E-10 19 467
6 gudmap dev gonad e11.5 M GonadVasMes Flk 500 dev gonad e11.5 M GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 9.728E-14 3.517E-11 2.997E-10 2.742E-10 18 419
7 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB 500 dev gonad e13.5 F VascAssocMesenchStromOvary MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.015E-13 3.517E-11 2.997E-10 2.860E-10 17 358
8 gudmap dev gonad e11.5 F GonadVasMes Flk 500 dev gonad e11.5 F GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.191E-13 3.517E-11 2.997E-10 3.357E-10 18 424
9 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 1.324E-13 3.517E-11 2.997E-10 3.732E-10 19 494
10 PCBC ctl BronchSmoothMuscl 500 Progenitor-Cell-Biology-Consortium reference BronchSmoothMuscl top-relative-expression-ranked 500 PCBC 1.324E-13 3.517E-11 2.997E-10 3.732E-10 19 494
11 PCBC ctl CardiacMyocyte 500 Progenitor-Cell-Biology-Consortium reference CardiacMyocyte top-relative-expression-ranked 500 PCBC 1.372E-13 3.517E-11 2.997E-10 3.868E-10 19 495
12 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma 500 dev gonad e13.5 F VascAssocMesenchStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.974E-13 4.637E-11 3.952E-10 5.565E-10 17 373
13 gudmap kidney adult RenalCapsule 200 kidney adult RenalCapsule top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.902E-13 7.937E-11 6.763E-10 1.100E-9 13 176
14 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 3.942E-13 7.937E-11 6.763E-10 1.111E-9 18 455
15 gudmap kidney adult RenalCapsule k1 500 kidney adult RenalCapsule k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.303E-12 2.449E-10 2.087E-9 3.673E-9 14 242
16 GSM605868 500 Myeloid Cells, Mo.6C+II+.Bl, CD115+ B220- CD43+ Ly6C+ MHCIIint, Blood, avg-4 Immgen.org, GSE15907 1.054E-11 1.858E-9 1.583E-8 2.973E-8 16 408
17 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 1.856E-11 3.077E-9 2.622E-8 5.232E-8 17 496
18 gudmap dev gonad e11.5 F GonMes Sma 500 dev gonad e11.5 F GonMes Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.938E-11 4.602E-9 3.921E-8 8.283E-8 16 437
19 gudmap kidney adult RenalCapsule k2 1000 kidney adult RenalCapsule k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.249E-11 4.821E-9 4.108E-8 9.160E-8 15 371
20 gudmap kidney adult RenalCapsule k3 200 kidney adult RenalCapsule k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.552E-11 5.007E-9 4.267E-8 1.001E-7 10 112
21 gudmap dev gonad e12.5 F VasAssocMesStromOvary Sma 500 dev gonad e12.5 F VasAssocMesStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 5.671E-11 7.612E-9 6.487E-8 1.599E-7 15 386
22 54Dn SubClass 54Dn 1SK Top 500 Cluster 2 54Dn SubClass 54Dn 1SK Top 500 Cluster 2 Brain Map - Allen iN 6.942E-11 8.895E-9 7.580E-8 1.957E-7 13 265
23 gudmap kidney adult RenalCapsule 100 kidney adult RenalCapsule top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.154E-10 1.414E-8 1.205E-7 3.252E-7 9 89
24 JC fibro 500 JC fibro top-relative-expression-ranked 500 PCBC 1.960E-10 2.303E-8 1.962E-7 5.527E-7 16 497
25 gudmap dev gonad e13.5 M InterstitTestis Sma 500 dev gonad e13.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.807E-10 3.165E-8 2.697E-7 7.912E-7 14 362
26 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma k2 500 dev gonad e13.5 F VascAssocMesenchStromOvary Sma k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.640E-10 3.947E-8 3.364E-7 1.026E-6 9 101
27 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 4.098E-10 4.279E-8 3.646E-7 1.155E-6 15 445
28 gudmap dev gonad e11.5 M GonMes Sma k3 1000 dev gonad e11.5 M GonMes Sma k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 5.195E-10 5.091E-8 4.339E-7 1.465E-6 13 312
29 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 5.238E-10 5.091E-8 4.339E-7 1.476E-6 15 453
30 gudmap dev gonad e11.5 F GonMes Sma k3 500 dev gonad e11.5 F GonMes Sma k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.053E-10 5.688E-8 4.847E-7 1.706E-6 10 149
31 gudmap dev gonad e12.5 F VasAssMesen MafB 500 dev gonad e12.5 F VasAssMesen MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 7.157E-10 6.509E-8 5.546E-7 2.018E-6 14 389
32 JC fibro 500 K3 JC fibro top-relative-expression-ranked 500 k-means-cluster#3 PCBC 9.162E-10 8.071E-8 6.878E-7 2.583E-6 11 206
33 gudmap dev gonad e11.5 F GonMes Sma k4 1000 dev gonad e11.5 F GonMes Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 9.559E-10 8.165E-8 6.958E-7 2.695E-6 13 328
34 gudmap dev gonad e11.5 M GonadVasMes Flk k4 500 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.015E-9 8.304E-8 7.077E-7 2.861E-6 11 208
35 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB k2 1000 dev gonad e13.5 F VascAssocMesenchStromOvary MafB k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.031E-9 8.304E-8 7.077E-7 2.907E-6 12 266
36 gudmap dev gonad e11.5 M GonadVasMes Flk k1 1000 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.376E-9 1.078E-7 9.184E-7 3.880E-6 13 338
37 GSM605872 500 Myeloid Cells, Mo.6C+II-.Bl, Cd115+ B220- CD43+ Ly6C+ MHCII-, Blood, avg-3 Immgen.org, GSE15907 1.457E-9 1.110E-7 9.457E-7 4.106E-6 14 411
38 54Dn Top 500 Cluster 1 54Dn Top 500 Cluster 1 Brain Map - Allen iN 1.546E-9 1.147E-7 9.773E-7 4.358E-6 10 164
39 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 1.667E-9 1.205E-7 1.027E-6 4.699E-6 15 493
40 GSM605859 500 Myeloid Cells, MF.Thio5.II+480lo.PC, CD115+ MHC II+ F480lo SiglecF- CD11c+, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 2.308E-9 1.627E-7 1.386E-6 6.507E-6 14 426
41 gudmap dev gonad e11.5 F GonadVasMes Flk k3 1000 dev gonad e11.5 F GonadVasMes Flk k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.490E-9 1.712E-7 1.459E-6 7.020E-6 13 355
42 gudmap dev gonad e11.5 M GonMes Sma 500 dev gonad e11.5 M GonMes Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.844E-9 1.909E-7 1.627E-6 8.017E-6 14 433
43 80Dn Top 500 Cluster 2 80Dn Top 500 Cluster 2 Brain Map - Allen iN 3.061E-9 2.007E-7 1.710E-6 8.629E-6 11 231
44 gudmap developingKidney e14.5 whole kidney - Wnt4 KO 500 k1 DevelopingKidney e14.5 whole kidney - Wnt4 KO emap-6674 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.053E-9 2.596E-7 2.213E-6 1.142E-5 8 91
45 gudmap dev gonad e11.5 F GonMes Sma 200 dev gonad e11.5 F GonMes Sma top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 4.472E-9 2.801E-7 2.387E-6 1.261E-5 10 183
46 GSM777063 500 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 4.648E-9 2.848E-7 2.427E-6 1.310E-5 14 450
47 gudmap kidney P0 JuxtaGlom Ren1 500 kidney P0 JuxtaGlom Ren1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.500E-9 3.299E-7 2.811E-6 1.550E-5 14 456
48 gudmap dev gonad e12.5 F VasAssMesen MafB k4 500 dev gonad e12.5 F VasAssMesen MafB k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.028E-8 6.036E-7 5.144E-6 2.897E-5 9 147
49 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k4 1000 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.091E-8 6.209E-7 5.291E-6 3.076E-5 11 261
50 GSM854320 500 Myeloid Cells, MF.Lv, CD45+ F4/80+ CD11b+, Liver, avg-2 Immgen.org, GSE15907 1.101E-8 6.209E-7 5.291E-6 3.105E-5 13 402
Show 45 more annotations

15: Computational [Display Chart] 241 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 3.520E-7 8.484E-5 5.145E-4 8.484E-5 12 361
2 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 2.868E-5 2.595E-3 1.574E-2 6.911E-3 10 378
3 module 19 Genes in module 19 MSigDb: C4 - CM: Cancer Modules 3.418E-5 2.595E-3 1.574E-2 8.238E-3 9 307
4 module 44 Genes in module 44 MSigDb: C4 - CM: Cancer Modules 4.616E-5 2.595E-3 1.574E-2 1.113E-2 9 319
5 module 6 Genes in module 6 MSigDb: C4 - CM: Cancer Modules 5.383E-5 2.595E-3 1.574E-2 1.297E-2 10 407
6 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 9.672E-5 3.885E-3 2.356E-2 2.331E-2 9 351
7 module 3 Genes in module 3 MSigDb: C4 - CM: Cancer Modules 1.600E-4 5.509E-3 3.341E-2 3.856E-2 9 375
8 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 2.364E-4 7.122E-3 4.319E-2
5.698E-2
 9 395
9 module 60 Genes in module 60 MSigDb: C4 - CM: Cancer Modules 3.119E-4 8.353E-3
5.065E-2
7.517E-2
 9 410
10 module 15 Genes in module 15 MSigDb: C4 - CM: Cancer Modules 5.350E-4 1.289E-2
7.818E-2
1.289E-1
 8 350
11 module 38 Genes in module 38 MSigDb: C4 - CM: Cancer Modules 6.675E-4 1.375E-2
8.338E-2
1.609E-1
 9 455
12 module 324 Genes in module 324 MSigDb: C4 - CM: Cancer Modules 6.846E-4 1.375E-2
8.338E-2
1.650E-1
 5 131
13 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 1.044E-3 1.935E-2
1.174E-1
2.516E-1
 6 216
14 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 1.720E-3 2.934E-2
1.779E-1
4.145E-1
 8 419
15 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 1.826E-3 2.934E-2
1.779E-1
4.401E-1
 8 423
16 module 24 Genes in module 24 MSigDb: C4 - CM: Cancer Modules 2.510E-3 3.780E-2
2.292E-1
6.049E-1
 8 445
Show 11 more annotations

16: MicroRNA [Display Chart] 995 annotations before applied cutoff / 19844 genes in category

No results to display

17: Drug [Display Chart] 16312 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 D017258 Medroxyprogesterone Acetate CTD 2.470E-12 4.029E-8 4.140E-7 4.029E-8 16 390
2 D007461 Iodoacetates CTD 2.177E-7 1.775E-3 1.824E-2 3.551E-3 4 14
3 D003994 Bucladesine CTD 3.391E-7 1.844E-3 1.895E-2 5.531E-3 10 305
4 C039671 ciglitazone CTD 4.766E-7 1.944E-3 1.997E-2 7.774E-3 9 242
5 C095105 bexarotene CTD 8.829E-7 2.880E-3 2.960E-2 1.440E-2 11 425
6 D003035 Cobalt CTD 1.423E-6 3.867E-3 3.975E-2 2.320E-2 9 276
7 CID005287847 DB04649 Stitch 1.958E-6 4.562E-3 4.688E-2 3.193E-2 7 148
8 C488369 dasatinib CTD 2.442E-6 4.609E-3 4.737E-2 3.983E-2 11 472
9 D000069439 Dasatinib CTD 2.543E-6 4.609E-3 4.737E-2 4.148E-2 11 474
10 C506614 PD 0325901 CTD 4.339E-6 6.788E-3
6.976E-2
7.078E-2
 6 108
11 C020738 9,10-dihydro-9,10-dihydroxybenzo(a)pyrene CTD 4.577E-6 6.788E-3
6.976E-2
7.467E-2
 6 109
12 CID000013328 DHTP Stitch 6.501E-6 8.078E-3
8.302E-2
1.060E-1
 4 31
13 3998 DN Etifenin [63245-28-3]; Down 200; 12.4uM; PC3; HT HG-U133A Broad Institute CMAP 6.641E-6 8.078E-3
8.302E-2
1.083E-1
 7 178
14 MESH:D001943/D009532-M Breast Neoplasms affected by Nickel CTD Marker 6.933E-6 8.078E-3
8.302E-2
1.131E-1
 3 10
15 D015025 Zearalenone CTD 8.939E-6 9.721E-3
9.990E-2
1.458E-1
 9 346
16 D003634 DDT CTD 1.199E-5 1.190E-2
1.223E-1
1.956E-1
 8 272
17 D019287 Zinc Sulfate CTD 1.325E-5 1.190E-2
1.223E-1
2.161E-1
 10 460
18 C017180 decamethrin CTD 1.377E-5 1.190E-2
1.223E-1
2.246E-1
 6 132
19 CID000107738 propionyl-L-carnitine Stitch 1.493E-5 1.190E-2
1.223E-1
2.436E-1
 4 38
20 MESH:D002471/D008748-M Cell Transformation, Neoplastic affected by Methylcholanthrene CTD Marker 1.532E-5 1.190E-2
1.223E-1
2.499E-1
 2 2
21 C010473 iodoform CTD 1.532E-5 1.190E-2
1.223E-1
2.499E-1
 2 2
22 C019003 methaneselenol CTD 1.638E-5 1.215E-2
1.248E-1
2.673E-1
 3 13
23 C014153 pirimiphos methyl CTD 2.592E-5 1.760E-2
1.809E-1
4.228E-1
 3 15
24 C040534 alpha-hexachlorocyclohexane CTD 2.695E-5 1.760E-2
1.809E-1
4.396E-1
 5 89
25 D017965 gamma-Linolenic Acid CTD 2.698E-5 1.760E-2
1.809E-1
4.400E-1
 4 44
26 D002762 Cholecalciferol CTD 2.941E-5 1.845E-2
1.896E-1
4.798E-1
 7 224
27 D002185 Cannabidiol CTD 3.177E-5 1.919E-2
1.972E-1
5.182E-1
 6 153
28 CID003025353 L024104 Stitch 3.820E-5 2.226E-2
2.287E-1
6.232E-1
 4 48
29 MESH:D006528/D014212-T Carcinoma, Hepatocellular affected by Tretinoin CTD Therapeutic 4.495E-5 2.266E-2
2.329E-1
7.332E-1
 4 50
30 1548 UP Retinoic acid [302-79-4]; Up 200; 13.4uM; HL60; HG-U133A Broad Institute CMAP 4.529E-5 2.266E-2
2.329E-1
7.388E-1
 6 163
31 CID003037579 carbaphethiol Stitch 4.585E-5 2.266E-2
2.329E-1
7.479E-1
 2 3
32 CID002779938 trimethylthiourea Stitch 4.585E-5 2.266E-2
2.329E-1
7.479E-1
 2 3
33 CID000107544 L-Tyrosine beta-naphthylamide Stitch 4.585E-5 2.266E-2
2.329E-1
7.479E-1
 2 3
34 C032668 1-nitropyrene CTD 5.196E-5 2.448E-2
2.516E-1
8.476E-1
 7 245
35 C573693 2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid CTD 5.252E-5 2.448E-2
2.516E-1
8.567E-1
 4 52
36 D002101 Cacodylic Acid CTD 5.755E-5 2.597E-2
2.668E-1
9.387E-1
 7 249
37 C014464 3,4-dichloroaniline CTD 5.914E-5 2.597E-2
2.668E-1
9.647E-1
 6 171
38 C028451 3,4,3',4'-tetrachlorobiphenyl CTD 6.101E-5 2.597E-2
2.668E-1
9.953E-1
 9 442
39 CID000002514 cadmium Stitch 6.208E-5 2.597E-2
2.668E-1
1.000E0
 9 443
40 D013196 Dihydrotestosterone CTD 6.916E-5 2.815E-2
2.893E-1
1.000E0
 8 348
41 4585 DN Captopril [62571-86-2]; Down 200; 17.2uM; PC3; HT HG-U133A Broad Institute CMAP 7.619E-5 2.815E-2
2.893E-1
1.000E0
 6 179
42 4456 UP troglitazone; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 7.619E-5 2.815E-2
2.893E-1
1.000E0
 6 179
43 CID000020138 butenal Stitch 7.857E-5 2.815E-2
2.893E-1
1.000E0
 6 180
44 D003345 Corticosterone CTD 8.111E-5 2.815E-2
2.893E-1
1.000E0
 7 263
45 C019304 ciprofibrate CTD 8.464E-5 2.815E-2
2.893E-1
1.000E0
 5 113
46 D007811 Lanthanum CTD 8.599E-5 2.815E-2
2.893E-1
1.000E0
 3 22
47 CID003033963 BN 50730 Stitch 8.599E-5 2.815E-2
2.893E-1
1.000E0
 3 22
48 C017557 nickel subsulfide CTD 9.138E-5 2.815E-2
2.893E-1
1.000E0
 6 185
49 CID000151522 benzyl beta-D-xyloside Stitch 9.146E-5 2.815E-2
2.893E-1
1.000E0
 2 4
50 C111599 istradefylline CTD 9.146E-5 2.815E-2
2.893E-1
1.000E0
 2 4
Show 45 more annotations

18: Disease [Display Chart] 1519 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0730295 BASAL LAMINAR DRUSEN (disorder) DisGeNET Curated 2.071E-5 1.595E-2
1.260E-1
 3.146E-2 2 2
2 umls:C0042025 Urinary Stress Incontinence DisGeNET BeFree 3.242E-5 1.595E-2
1.260E-1
 4.924E-2 3 14
3 umls:C0151786 Muscle Weakness DisGeNET Curated 4.071E-5 1.595E-2
1.260E-1
6.183E-2
 7 204
4 umls:C0153690 Secondary malignant neoplasm of bone DisGeNET BeFree 4.923E-5 1.595E-2
1.260E-1
7.478E-2
 8 287
5 umls:C0410702 Adolescent idiopathic scoliosis DisGeNET BeFree 5.249E-5 1.595E-2
1.260E-1
7.973E-2
 4 45
6 umls:C0260037 Multiple tumors DisGeNET BeFree 7.784E-5 1.971E-2
1.557E-1
1.182E-1
 5 96
7 umls:C1862939 AMYOTROPHIC LATERAL SCLEROSIS 1 DisGeNET Curated 1.120E-4 2.431E-2
1.921E-1
1.701E-1
 6 166
8 umls:C0030552 Paresis DisGeNET Curated 1.421E-4 2.697E-2
2.132E-1
2.158E-1
 5 109
9 umls:C3714524 Fibromyxosarcoma DisGeNET BeFree 1.975E-4 3.118E-2
2.464E-1
3.001E-1
 3 25
10 umls:C0153658 Malignant neoplasm of endocrine gland DisGeNET BeFree 2.053E-4 3.118E-2
2.464E-1
3.118E-1
 2 5
11 umls:C1709246 Non-Neoplastic Disorder DisGeNET BeFree 2.482E-4 3.428E-2
2.709E-1
3.770E-1
 9 461
12 umls:C1268935 Congenital Thrombotic Thrombocytopenic Purpura DisGeNET Curated 3.070E-4 3.803E-2
3.006E-1
4.664E-1
 2 6
13 umls:C0025286 Meningioma DisGeNET Curated 3.577E-4 3.803E-2
3.006E-1
5.434E-1
 8 383
14 umls:C0038356 Stomach Neoplasms DisGeNET Curated 3.884E-4 3.803E-2
3.006E-1
5.900E-1
 9 490
15 umls:C1704374 Carcinoma of Endocrine Gland DisGeNET BeFree 4.285E-4 3.803E-2
3.006E-1
6.510E-1
 2 7
16 umls:C0271183 Severe myopia DisGeNET BeFree 4.483E-4 3.803E-2
3.006E-1
6.810E-1
 4 78
17 umls:C0018273 Growth Disorders DisGeNET Curated 4.565E-4 3.803E-2
3.006E-1
6.934E-1
 3 33
18 umls:C0038580 Substance Dependence DisGeNET Curated 4.706E-4 3.803E-2
3.006E-1
7.149E-1
 4 79
19 umls:C0003507 Aortic Valve Stenosis DisGeNET BeFree 4.937E-4 3.803E-2
3.006E-1
7.499E-1
 4 80
20 20081125:Gudbjartsson Height GWAS 5.167E-4 3.803E-2
3.006E-1
7.848E-1
 5 144
21 umls:C0555198 Malignant Glioma DisGeNET BeFree 5.801E-4 3.803E-2
3.006E-1
8.812E-1
 8 412
22 umls:C0005695 Bladder Neoplasm DisGeNET Curated 6.021E-4 3.803E-2
3.006E-1
9.145E-1
 7 316
23 umls:C0029928 Ovarian Diseases DisGeNET Curated 6.607E-4 3.803E-2
3.006E-1
1.000E0
 6 231
24 umls:C0206651 Sarcoma, Clear Cell DisGeNET Curated 6.943E-4 3.803E-2
3.006E-1
1.000E0
 3 38
25 umls:C0162291 Retinal ischemia DisGeNET BeFree 7.303E-4 3.803E-2
3.006E-1
1.000E0
 2 9
26 umls:C1706827 Apocrine Gland Carcinoma DisGeNET BeFree 7.303E-4 3.803E-2
3.006E-1
1.000E0
 2 9
27 umls:C0280280 stage, prostate cancer DisGeNET BeFree 7.497E-4 3.803E-2
3.006E-1
1.000E0
 3 39
28 umls:C1519670 Tumor Angiogenesis DisGeNET BeFree 9.303E-4 3.803E-2
3.006E-1
1.000E0
 8 443
29 umls:C0272138 Erythroblastosis DisGeNET BeFree 9.325E-4 3.803E-2
3.006E-1
1.000E0
 3 42
30 umls:C0238463 Papillary thyroid carcinoma DisGeNET Curated 9.716E-4 3.803E-2
3.006E-1
1.000E0
 8 446
31 umls:C0242383 Age related macular degeneration DisGeNET Curated 1.042E-3 3.803E-2
3.006E-1
1.000E0
 7 347
32 umls:C0598894 Monocytic leukemia DisGeNET BeFree 1.069E-3 3.803E-2
3.006E-1
1.000E0
 3 44
33 umls:C0034067 Pulmonary Emphysema DisGeNET Curated 1.212E-3 3.803E-2
3.006E-1
1.000E0
 5 174
34 umls:C0007786 Brain Ischemia DisGeNET Curated 1.321E-3 3.803E-2
3.006E-1
1.000E0
 4 104
35 umls:C2348820 Triple-Negative Breast Carcinoma DisGeNET BeFree 1.327E-3 3.803E-2
3.006E-1
1.000E0
 2 12
36 umls:C0020302 Hydrophthalmos DisGeNET Curated 1.327E-3 3.803E-2
3.006E-1
1.000E0
 2 12
37 umls:C0234233 Sore to touch DisGeNET BeFree 1.327E-3 3.803E-2
3.006E-1
1.000E0
 2 12
38 umls:C0345967 Malignant mesothelioma DisGeNET Curated 1.344E-3 3.803E-2
3.006E-1
1.000E0
 6 265
39 umls:C1512409 Hepatocarcinogenesis DisGeNET BeFree 1.377E-3 3.803E-2
3.006E-1
1.000E0
 8 471
40 umls:C0598589 Inherited neuropathies DisGeNET BeFree 1.463E-3 3.803E-2
3.006E-1
1.000E0
 3 49
41 umls:C0014474 Ependymoma DisGeNET Curated 1.519E-3 3.803E-2
3.006E-1
1.000E0
 4 108
42 umls:C0855173 Placental Choriocarcinoma DisGeNET BeFree 1.564E-3 3.803E-2
3.006E-1
1.000E0
 2 13
43 umls:C0574769 Loss of scalp hair DisGeNET BeFree 1.819E-3 3.803E-2
3.006E-1
1.000E0
 2 14
44 umls:C0206081 Hyperandrogenism DisGeNET Curated 1.835E-3 3.803E-2
3.006E-1
1.000E0
 3 53
45 umls:C0349204 Nonorganic psychosis DisGeNET BeFree 1.870E-3 3.803E-2
3.006E-1
1.000E0
 5 192
46 umls:C0023267 Fibroid Tumor DisGeNET Curated 2.013E-3 3.803E-2
3.006E-1
1.000E0
 6 287
47 umls:C0151514 Atrophic condition of skin DisGeNET BeFree 2.102E-3 3.803E-2
3.006E-1
1.000E0
 4 118
48 umls:C0041696 Unipolar Depression DisGeNET BeFree 2.514E-3 3.803E-2
3.006E-1
1.000E0
 7 405
49 umls:C0003486 Aortic Aneurysm DisGeNET Curated 2.594E-3 3.803E-2
3.006E-1
1.000E0
 5 207
50 umls:C0027092 Myopia DisGeNET Curated 2.823E-3 3.803E-2
3.006E-1
1.000E0
 4 128
Show 45 more annotations