Toppgene analysis for aggregated_1964_log, IC2, positive side

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1: GO: Molecular Function [Display Chart] 685 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008094 DNA-dependent ATPase activity 1.931E-19 1.323E-16 9.400E-16 1.323E-16 21 93
2 GO:0003678 DNA helicase activity 3.835E-17 1.314E-14 9.337E-14 2.627E-14 17 65
3 GO:0004386 helicase activity 7.610E-16 1.306E-13 9.283E-13 5.213E-13 23 172
4 GO:0003697 single-stranded DNA binding 8.621E-16 1.306E-13 9.283E-13 5.905E-13 19 105
5 GO:0003684 damaged DNA binding 9.534E-16 1.306E-13 9.283E-13 6.531E-13 16 65
6 GO:0043142 single-stranded DNA-dependent ATPase activity 5.229E-12 5.969E-10 4.243E-9 3.582E-9 8 14
7 GO:0016887 ATPase activity 1.899E-11 1.858E-9 1.321E-8 1.301E-8 29 446
8 GO:0000217 DNA secondary structure binding 4.439E-11 3.801E-9 2.702E-8 3.041E-8 9 25
9 GO:0042623 ATPase activity, coupled 4.068E-9 3.096E-7 2.201E-6 2.786E-6 22 332
10 GO:0004536 deoxyribonuclease activity 7.831E-9 5.284E-7 3.756E-6 5.364E-6 13 110
11 GO:0004518 nuclease activity 8.486E-9 5.284E-7 3.756E-6 5.813E-6 18 230
12 GO:0042393 histone binding 1.037E-8 5.922E-7 4.209E-6 7.107E-6 16 181
13 GO:0043138 3'-5' DNA helicase activity 1.452E-8 7.651E-7 5.438E-6 9.946E-6 6 13
14 GO:0004003 ATP-dependent DNA helicase activity 2.235E-8 1.094E-6 7.773E-6 1.531E-5 9 47
15 GO:0004527 exonuclease activity 2.971E-8 1.357E-6 9.643E-6 2.035E-5 11 82
16 GO:0000400 four-way junction DNA binding 6.530E-8 2.796E-6 1.987E-5 4.473E-5 6 16
17 GO:0004520 endodeoxyribonuclease activity 1.401E-7 5.325E-6 3.785E-5 9.597E-5 11 95
18 GO:0016895 exodeoxyribonuclease activity, producing 5'-phosphomonoesters 1.477E-7 5.325E-6 3.785E-5 1.012E-4 6 18
19 GO:0004529 exodeoxyribonuclease activity 1.477E-7 5.325E-6 3.785E-5 1.012E-4 6 18
20 GO:0034061 DNA polymerase activity 3.605E-7 1.235E-5 8.775E-5 2.469E-4 8 47
21 GO:0032405 MutLalpha complex binding 6.540E-7 2.133E-5 1.516E-4 4.480E-4 4 6
22 GO:0017056 structural constituent of nuclear pore 2.460E-6 7.659E-5 5.444E-4 1.685E-3 5 16
23 GO:0003887 DNA-directed DNA polymerase activity 2.651E-6 7.895E-5 5.611E-4 1.816E-3 6 28
24 GO:0032404 mismatch repair complex binding 2.982E-6 8.512E-5 6.050E-4 2.043E-3 4 8
25 GO:0033170 protein-DNA loading ATPase activity 5.306E-6 1.328E-4 9.438E-4 3.635E-3 4 9
26 GO:0003688 DNA replication origin binding 5.306E-6 1.328E-4 9.438E-4 3.635E-3 4 9
27 GO:0003689 DNA clamp loader activity 5.306E-6 1.328E-4 9.438E-4 3.635E-3 4 9
28 GO:0008026 ATP-dependent helicase activity 5.757E-6 1.328E-4 9.438E-4 3.943E-3 10 112
29 GO:0070035 purine NTP-dependent helicase activity 5.757E-6 1.328E-4 9.438E-4 3.943E-3 10 112
30 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5.816E-6 1.328E-4 9.438E-4 3.984E-3 7 48
31 GO:0004519 endonuclease activity 6.562E-6 1.450E-4 1.031E-3 4.495E-3 12 167
32 GO:0008408 3'-5' exonuclease activity 1.005E-5 2.152E-4 1.530E-3 6.887E-3 7 52
33 GO:0008309 double-stranded DNA exodeoxyribonuclease activity 1.221E-5 2.535E-4 1.802E-3 8.366E-3 3 4
34 GO:0030983 mismatched DNA binding 2.014E-5 4.057E-4 2.883E-3 1.379E-2 4 12
35 GO:0051539 4 iron, 4 sulfur cluster binding 2.698E-5 5.280E-4 3.753E-3 1.848E-2 6 41
36 GO:0070182 DNA polymerase binding 2.875E-5 5.471E-4 3.888E-3 1.969E-2 4 13
37 GO:0032135 DNA insertion or deletion binding 5.975E-5 1.077E-3 7.656E-3 4.093E-2 3 6
38 GO:0003910 DNA ligase (ATP) activity 5.975E-5 1.077E-3 7.656E-3 4.093E-2 3 6
39 GO:0003909 DNA ligase activity 1.034E-4 1.817E-3 1.291E-2
7.085E-2
 3 7
40 GO:0016779 nucleotidyltransferase activity 1.413E-4 2.232E-3 1.586E-2
9.677E-2
 9 132
41 GO:0035173 histone kinase activity 1.454E-4 2.232E-3 1.586E-2
9.963E-2
 4 19
42 GO:0044824 retroviral 3' processing activity 1.466E-4 2.232E-3 1.586E-2
1.004E-1
 6 55
43 GO:0008907 integrase activity 1.466E-4 2.232E-3 1.586E-2
1.004E-1
 6 55
44 GO:0044823 retroviral integrase activity 1.466E-4 2.232E-3 1.586E-2
1.004E-1
 6 55
45 GO:0043765 T/G mismatch-specific endonuclease activity 1.466E-4 2.232E-3 1.586E-2
1.004E-1
 6 55
46 GO:0036310 annealing helicase activity 1.637E-4 2.243E-3 1.594E-2
1.121E-1
 3 8
47 GO:0048256 flap endonuclease activity 1.637E-4 2.243E-3 1.594E-2
1.121E-1
 3 8
48 GO:0003896 DNA primase activity 1.637E-4 2.243E-3 1.594E-2
1.121E-1
 3 8
49 GO:0000150 recombinase activity 1.637E-4 2.243E-3 1.594E-2
1.121E-1
 3 8
50 GO:0032552 deoxyribonucleotide binding 1.637E-4 2.243E-3 1.594E-2
1.121E-1
 3 8
Show 45 more annotations

2: GO: Biological Process [Display Chart] 2504 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006260 DNA replication 2.401E-72 6.011E-69 5.051E-68 6.011E-69 79 346
2 GO:0006261 DNA-dependent DNA replication 1.082E-55 1.354E-52 1.138E-51 2.708E-52 49 134
3 GO:0006310 DNA recombination 9.770E-50 8.154E-47 6.852E-46 2.446E-46 57 268
4 GO:0071103 DNA conformation change 9.737E-37 6.096E-34 5.122E-33 2.438E-33 48 285
5 GO:0000082 G1/S transition of mitotic cell cycle 1.060E-34 5.310E-32 4.462E-31 2.655E-31 44 248
6 GO:0006312 mitotic recombination 1.470E-34 6.135E-32 5.155E-31 3.681E-31 25 45
7 GO:0000731 DNA synthesis involved in DNA repair 5.474E-34 1.958E-31 1.645E-30 1.371E-30 29 75
8 GO:0044843 cell cycle G1/S phase transition 6.305E-34 1.973E-31 1.658E-30 1.579E-30 44 258
9 GO:0000722 telomere maintenance via recombination 1.369E-30 3.810E-28 3.202E-27 3.429E-27 21 34
10 GO:0006302 double-strand break repair 2.818E-30 7.056E-28 5.929E-27 7.056E-27 37 196
11 GO:0006270 DNA replication initiation 3.379E-30 7.692E-28 6.463E-27 8.461E-27 21 35
12 GO:0022616 DNA strand elongation 9.329E-30 1.947E-27 1.636E-26 2.336E-26 20 31
13 GO:0071897 DNA biosynthetic process 4.696E-29 9.045E-27 7.600E-26 1.176E-25 37 211
14 GO:0006271 DNA strand elongation involved in DNA replication 2.919E-28 5.221E-26 4.387E-25 7.309E-25 18 25
15 GO:0007067 mitotic nuclear division 2.889E-25 4.822E-23 4.052E-22 7.233E-22 46 455
16 GO:0000075 cell cycle checkpoint 4.429E-25 6.932E-23 5.825E-22 1.109E-21 35 234
17 GO:0000724 double-strand break repair via homologous recombination 7.447E-25 1.097E-22 9.217E-22 1.865E-21 25 93
18 GO:0000725 recombinational repair 1.001E-24 1.393E-22 1.171E-21 2.507E-21 25 94
19 GO:0000732 strand displacement 1.597E-23 2.104E-21 1.768E-20 3.998E-20 16 26
20 GO:0000723 telomere maintenance 1.389E-22 1.739E-20 1.462E-19 3.479E-19 27 140
21 GO:0051052 regulation of DNA metabolic process 3.790E-22 4.519E-20 3.797E-19 9.490E-19 39 370
22 GO:0032392 DNA geometric change 4.107E-22 4.674E-20 3.928E-19 1.028E-18 22 81
23 GO:0032200 telomere organization 1.644E-21 1.790E-19 1.504E-18 4.116E-18 27 153
24 GO:0032508 DNA duplex unwinding 2.467E-21 2.574E-19 2.163E-18 6.178E-18 21 76
25 GO:0007059 chromosome segregation 7.990E-21 8.003E-19 6.725E-18 2.001E-17 36 334
26 GO:0031570 DNA integrity checkpoint 1.580E-19 1.522E-17 1.279E-16 3.957E-16 26 164
27 GO:0072331 signal transduction by p53 class mediator 3.452E-19 3.201E-17 2.690E-16 8.644E-16 31 263
28 GO:0006323 DNA packaging 4.257E-19 3.589E-17 3.015E-16 1.066E-15 28 206
29 GO:0065004 protein-DNA complex assembly 4.299E-19 3.589E-17 3.015E-16 1.077E-15 29 225
30 GO:0000819 sister chromatid segregation 4.299E-19 3.589E-17 3.015E-16 1.077E-15 29 225
31 GO:0051321 meiotic cell cycle 2.315E-18 1.870E-16 1.571E-15 5.797E-15 29 239
32 GO:0098813 nuclear chromosome segregation 2.958E-18 2.314E-16 1.945E-15 7.406E-15 31 283
33 GO:0071824 protein-DNA complex subunit organization 1.113E-17 8.449E-16 7.100E-15 2.788E-14 29 253
34 GO:0007062 sister chromatid cohesion 2.229E-16 1.642E-14 1.379E-13 5.581E-13 21 127
35 GO:0007093 mitotic cell cycle checkpoint 2.608E-16 1.866E-14 1.568E-13 6.530E-13 23 162
36 GO:0000077 DNA damage checkpoint 1.038E-15 7.221E-14 6.068E-13 2.599E-12 22 154
37 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 1.242E-15 8.406E-14 7.064E-13 3.110E-12 12 27
38 GO:0000086 G2/M transition of mitotic cell cycle 2.009E-15 1.324E-13 1.113E-12 5.031E-12 24 197
39 GO:0042769 DNA damage response, detection of DNA damage 2.104E-15 1.351E-13 1.135E-12 5.269E-12 13 36
40 GO:0045930 negative regulation of mitotic cell cycle 4.520E-15 2.830E-13 2.378E-12 1.132E-11 25 225
41 GO:0044839 cell cycle G2/M phase transition 5.573E-15 3.404E-13 2.860E-12 1.396E-11 24 206
42 GO:0090305 nucleic acid phosphodiester bond hydrolysis 5.849E-15 3.444E-13 2.894E-12 1.465E-11 27 272
43 GO:1901796 regulation of signal transduction by p53 class mediator 5.914E-15 3.444E-13 2.894E-12 1.481E-11 22 167
44 GO:0006297 nucleotide-excision repair, DNA gap filling 1.288E-14 7.332E-13 6.161E-12 3.226E-11 11 24
45 GO:0006301 postreplication repair 3.331E-14 1.854E-12 1.558E-11 8.342E-11 14 54
46 GO:0044786 cell cycle DNA replication 3.573E-14 1.945E-12 1.635E-11 8.948E-11 12 34
47 GO:0006284 base-excision repair 4.254E-14 2.267E-12 1.905E-11 1.065E-10 13 44
48 GO:0006298 mismatch repair 5.367E-14 2.800E-12 2.353E-11 1.344E-10 12 35
49 GO:1903046 meiotic cell cycle process 1.707E-13 8.562E-12 7.194E-11 4.275E-10 22 196
50 GO:0010948 negative regulation of cell cycle process 1.710E-13 8.562E-12 7.194E-11 4.281E-10 24 240
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 289 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0098687 chromosomal region 2.922E-34 4.257E-32 2.659E-31 8.444E-32 49 345
2 GO:0005657 replication fork 2.946E-34 4.257E-32 2.659E-31 8.515E-32 28 67
3 GO:0000793 condensed chromosome 8.270E-25 7.967E-23 4.976E-22 2.390E-22 33 208
4 GO:0043596 nuclear replication fork 8.168E-18 5.901E-16 3.686E-15 2.361E-15 15 41
5 GO:0000781 chromosome, telomeric region 1.537E-17 8.881E-16 5.547E-15 4.441E-15 24 163
6 GO:0000775 chromosome, centromeric region 2.622E-17 1.263E-15 7.886E-15 7.576E-15 25 185
7 GO:0000784 nuclear chromosome, telomeric region 4.639E-16 1.915E-14 1.196E-13 1.341E-13 21 134
8 GO:0000785 chromatin 1.017E-15 3.674E-14 2.295E-13 2.939E-13 36 489
9 GO:0042555 MCM complex 1.336E-15 4.289E-14 2.679E-13 3.860E-13 9 11
10 GO:0030894 replisome 7.528E-15 2.175E-13 1.359E-12 2.175E-12 12 31
11 GO:0032993 protein-DNA complex 2.499E-11 6.565E-10 4.100E-9 7.221E-9 19 184
12 GO:0000779 condensed chromosome, centromeric region 3.129E-11 7.380E-10 4.609E-9 9.043E-9 15 105
13 GO:0000776 kinetochore 3.320E-11 7.380E-10 4.609E-9 9.594E-9 16 124
14 GO:0000777 condensed chromosome kinetochore 9.379E-11 1.936E-9 1.209E-8 2.710E-8 14 95
15 GO:0043601 nuclear replisome 1.352E-10 2.604E-9 1.626E-8 3.906E-8 9 28
16 GO:0000794 condensed nuclear chromosome 1.490E-9 2.692E-8 1.681E-7 4.307E-7 13 97
17 GO:0005663 DNA replication factor C complex 3.668E-9 6.235E-8 3.894E-7 1.060E-6 5 6
18 GO:0000790 nuclear chromatin 1.342E-8 2.155E-7 1.346E-6 3.879E-6 21 326
19 GO:0031261 DNA replication preinitiation complex 4.327E-8 6.582E-7 4.111E-6 1.251E-5 4 4
20 GO:0000792 heterochromatin 5.827E-8 8.421E-7 5.259E-6 1.684E-5 11 88
21 GO:0005819 spindle 1.325E-7 1.788E-6 1.116E-5 3.830E-5 19 308
22 GO:0005720 nuclear heterochromatin 1.361E-7 1.788E-6 1.116E-5 3.933E-5 8 42
23 GO:0016605 PML body 2.211E-7 2.779E-6 1.735E-5 6.391E-5 11 100
24 GO:0044450 microtubule organizing center part 2.528E-7 3.044E-6 1.901E-5 7.306E-5 13 148
25 GO:0000803 sex chromosome 3.085E-7 3.566E-6 2.227E-5 8.915E-5 7 32
26 GO:0005814 centriole 3.649E-7 4.056E-6 2.533E-5 1.055E-4 11 105
27 GO:0035861 site of double-strand break 3.867E-7 4.139E-6 2.585E-5 1.118E-4 7 33
28 GO:0031298 replication fork protection complex 6.344E-7 6.548E-6 4.089E-5 1.833E-4 4 6
29 GO:0005635 nuclear envelope 8.700E-7 8.670E-6 5.414E-5 2.514E-4 22 454
30 GO:0031390 Ctf18 RFC-like complex 1.463E-6 1.410E-5 8.804E-5 4.229E-4 4 7
31 GO:0070652 HAUS complex 2.893E-6 2.697E-5 1.684E-4 8.361E-4 4 8
32 GO:0000811 GINS complex 3.016E-6 2.724E-5 1.701E-4 8.718E-4 3 3
33 GO:0000922 spindle pole 3.864E-6 3.384E-5 2.113E-4 1.117E-3 11 133
34 GO:0005658 alpha DNA polymerase:primase complex 1.194E-5 1.015E-4 6.336E-4 3.450E-3 3 4
35 GO:0098536 deuterosome 2.952E-5 2.396E-4 1.497E-3 8.531E-3 3 5
36 GO:0034399 nuclear periphery 2.985E-5 2.396E-4 1.497E-3 8.627E-3 10 136
37 GO:0042575 DNA polymerase complex 3.862E-5 3.017E-4 1.884E-3 1.116E-2 4 14
38 GO:0043240 Fanconi anaemia nuclear complex 5.206E-5 3.960E-4 2.473E-3 1.505E-2 4 15
39 GO:0000796 condensin complex 5.840E-5 4.328E-4 2.703E-3 1.688E-2 3 6
40 GO:0001741 XY body 8.873E-5 6.410E-4 4.004E-3 2.564E-2 4 17
41 GO:0005721 pericentric heterochromatin 1.412E-4 9.955E-4 6.217E-3 4.082E-2 4 19
42 GO:0000930 gamma-tubulin complex 1.745E-4 1.201E-3 7.500E-3
5.044E-2
 4 20
43 GO:0032301 MutSalpha complex 2.095E-4 1.346E-3 8.403E-3
6.055E-2
 2 2
44 GO:0031436 BRCA1-BARD1 complex 2.095E-4 1.346E-3 8.403E-3
6.055E-2
 2 2
45 GO:1990077 primosome complex 2.095E-4 1.346E-3 8.403E-3
6.055E-2
 2 2
46 GO:0000808 origin recognition complex 2.375E-4 1.460E-3 9.120E-3
6.863E-2
 3 9
47 GO:0005664 nuclear origin of replication recognition complex 2.375E-4 1.460E-3 9.120E-3
6.863E-2
 3 9
48 GO:0061695 transferase complex, transferring phosphorus-containing groups 2.543E-4 1.531E-3 9.563E-3
7.349E-2
 12 245
49 GO:0031965 nuclear membrane 3.356E-4 1.979E-3 1.236E-2
9.697E-2
 13 290
50 GO:1990391 DNA repair complex 5.213E-4 3.013E-3 1.882E-2
1.507E-1
 5 46
Show 45 more annotations

4: Human Phenotype [Display Chart] 685 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0002575 Tracheoesophageal fistula 3.270E-9 1.424E-6 1.012E-5 2.240E-6 8 27
2 HP:0003221 Chromosomal breakage induced by crosslinking agents 4.266E-9 1.424E-6 1.012E-5 2.922E-6 6 11
3 HP:0001511 Intrauterine growth retardation 8.282E-9 1.424E-6 1.012E-5 5.673E-6 16 185
4 HP:0001909 Leukemia 8.317E-9 1.424E-6 1.012E-5 5.697E-6 8 30
5 HP:0002032 Esophageal atresia 1.108E-8 1.517E-6 1.079E-5 7.587E-6 8 31
6 HP:0009778 Short thumb {has synonym type="layperson"} 1.190E-7 1.230E-5 8.741E-5 8.150E-5 8 41
7 HP:0000957 Cafe-au-lait spot 1.257E-7 1.230E-5 8.741E-5 8.609E-5 9 57
8 HP:0003002 Breast carcinoma 1.452E-7 1.244E-5 8.838E-5 9.948E-5 8 42
9 HP:0000086 Ectopic kidney 8.077E-7 6.147E-5 4.369E-4 5.533E-4 6 23
10 HP:0009777 Absent thumb {has synonym type="layperson"} 1.064E-6 7.289E-5 5.181E-4 7.289E-4 6 24
11 HP:0003213 Deficient excision of UV-induced pyrimidine dimers in DNA 3.256E-6 1.716E-4 1.219E-3 2.230E-3 4 8
12 HP:0003214 Prolonged G2 phase of cell cycle 3.256E-6 1.716E-4 1.219E-3 2.230E-3 4 8
13 HP:0001017 Anemic pallor 3.256E-6 1.716E-4 1.219E-3 2.230E-3 4 8
14 HP:0009943 Complete duplication of thumb phalanx 5.794E-6 2.646E-4 1.880E-3 3.969E-3 4 9
15 HP:0003220 Abnormality of chromosome stability 5.794E-6 2.646E-4 1.880E-3 3.969E-3 4 9
16 HP:0000568 Microphthalmia 8.204E-6 3.512E-4 2.496E-3 5.620E-3 11 144
17 HP:0001876 Pancytopenia 9.272E-6 3.736E-4 2.655E-3 6.351E-3 7 51
18 HP:0003974 Absent radius 2.923E-5 1.112E-3 7.906E-3 2.002E-2 5 25
19 HP:0000081 Duplicated collecting system 3.140E-5 1.132E-3 8.046E-3 2.151E-2 4 13
20 HP:0001896 Reticulocytopenia 5.859E-5 2.007E-3 1.426E-2 4.013E-2 4 15
21 HP:0001873 Thrombocytopenia 7.195E-5 2.347E-3 1.668E-2 4.928E-2 10 150
22 HP:0000085 Horseshoe kidney {has synonym type="layperson"} 8.712E-5 2.712E-3 1.928E-2
5.967E-2
 5 31
23 HP:0001518 Small for gestational age {has synonym type="layperson"} 1.062E-4 3.163E-3 2.248E-2
7.275E-2
 8 99
24 HP:0003561 Birth length less than 3rd percentile 1.778E-4 5.075E-3 3.607E-2
1.218E-1
 3 8
25 HP:0001627 Abnormal heart morphology 2.083E-4 5.707E-3 4.056E-2
1.427E-1
 5 37
26 HP:0001000 Abnormality of skin pigmentation {has synonym type="layperson"} 4.114E-4 1.084E-2
7.704E-2
2.818E-1
 4 24
27 HP:0000340 Sloping forehead {has synonym type="layperson"} 4.780E-4 1.201E-2
8.536E-2
3.274E-1
 5 44
28 HP:0000028 Cryptorchidism 4.909E-4 1.201E-2
8.536E-2
3.363E-1
 13 302
29 HP:0000104 Renal agenesis 5.894E-4 1.392E-2
9.895E-2
4.037E-1
 5 46
30 HP:0003100 Slender long bone {has synonym type="layperson"} 6.566E-4 1.499E-2
1.066E-1
4.498E-1
 4 27
31 HP:0001889 Megaloblastic anemia 8.599E-4 1.859E-2
1.321E-1
5.890E-1
 3 13
32 HP:0005528 Bone marrow hypocellularity 8.685E-4 1.859E-2
1.321E-1
5.949E-1
 4 29
33 HP:0011451 Congenital microcephaly 1.338E-3 2.695E-2
1.916E-1
9.164E-1
 2 4
34 HP:0006628 Absent sternal ossification 1.338E-3 2.695E-2
1.916E-1
9.164E-1
 2 4
35 HP:0100843 Glioblastoma 1.630E-3 3.101E-2
2.204E-1
1.000E0
 3 16
36 HP:0002885 Medulloblastoma 1.630E-3 3.101E-2
2.204E-1
1.000E0
 3 16
37 HP:0008665 Clitoral hypertrophy 1.788E-3 3.310E-2
2.353E-1
1.000E0
 4 35
38 HP:0002665 Lymphoma 1.989E-3 3.585E-2
2.548E-1
1.000E0
 4 36
39 HP:0001903 Anemia 2.291E-3 4.024E-2
2.860E-1
1.000E0
 7 122
Show 34 more annotations

5: Mouse Phenotype [Display Chart] 2118 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008866 chromosomal instability 2.597E-27 4.903E-24 4.038E-23 5.501E-24 30 113
2 MP:0010094 abnormal chromosome stability 4.630E-27 4.903E-24 4.038E-23 9.807E-24 30 115
3 MP:0003077 abnormal cell cycle 1.050E-18 7.414E-16 6.106E-15 2.224E-15 35 309
4 MP:0004028 chromosome breakage 1.172E-17 6.207E-15 5.112E-14 2.483E-14 19 71
5 MP:0003111 abnormal cell nucleus morphology 7.869E-17 3.333E-14 2.745E-13 1.667E-13 26 177
6 MP:0004046 abnormal mitosis 1.120E-14 3.953E-12 3.256E-11 2.372E-11 22 145
7 MP:0012431 increased lymphoma incidence 2.674E-14 8.092E-12 6.664E-11 5.664E-11 27 244
8 MP:0010296 increased hemolymphoid system tumor incidence 5.014E-14 1.327E-11 1.093E-10 1.062E-10 29 293
9 MP:0008058 abnormal DNA repair 1.384E-11 3.122E-9 2.571E-8 2.932E-8 17 112
10 MP:0011096 embryonic lethality between implantation and somite formation, complete penetrance 1.474E-11 3.122E-9 2.571E-8 3.122E-8 25 270
11 MP:0009850 embryonic lethality between implantation and placentation 4.999E-11 9.625E-9 7.927E-8 1.059E-7 31 439
12 MP:0006205 embryonic lethality between implantation and somite formation 1.357E-10 2.395E-8 1.972E-7 2.874E-7 25 299
13 MP:0006204 embryonic lethality before implantation 1.806E-10 2.943E-8 2.424E-7 3.826E-7 19 169
14 MP:0004966 abnormal inner cell mass proliferation 1.958E-10 2.961E-8 2.439E-7 4.146E-7 13 68
15 MP:0004023 abnormal chromosome number 2.226E-10 3.144E-8 2.589E-7 4.716E-7 14 83
16 MP:0008943 increased sensitivity to induced cell death 3.000E-10 3.971E-8 3.271E-7 6.354E-7 19 174
17 MP:0011094 embryonic lethality before implantation, complete penetrance 8.081E-10 1.007E-7 8.291E-7 1.711E-6 17 144
18 MP:0009308 increased adenocarcinoma incidence 2.193E-9 2.580E-7 2.125E-6 4.645E-6 18 174
19 MP:0008942 abnormal induced cell death 3.697E-9 4.121E-7 3.394E-6 7.831E-6 21 248
20 MP:0004030 induced chromosome breakage 5.790E-9 6.131E-7 5.049E-6 1.226E-5 8 24
21 MP:0003702 abnormal chromosome morphology 7.256E-9 7.318E-7 6.027E-6 1.537E-5 12 74
22 MP:0013503 abnormal embryonic tissue cell apoptosis 1.153E-8 1.110E-6 9.144E-6 2.443E-5 17 171
23 MP:0004024 aneuploidy 1.402E-8 1.291E-6 1.063E-5 2.970E-5 11 63
24 MP:0004227 increased cellular sensitivity to ionizing radiation 2.095E-8 1.849E-6 1.523E-5 4.437E-5 12 81
25 MP:0008932 abnormal embryonic tissue physiology 2.184E-8 1.850E-6 1.524E-5 4.626E-5 22 300
26 MP:0002718 abnormal inner cell mass morphology 3.193E-8 2.601E-6 2.142E-5 6.762E-5 12 84
27 MP:0002038 increased carcinoma incidence 4.182E-8 3.281E-6 2.702E-5 8.857E-5 22 311
28 MP:0011702 abnormal fibroblast proliferation 5.379E-8 4.069E-6 3.351E-5 1.139E-4 16 167
29 MP:0012114 absent inner cell mass proliferation 5.800E-8 4.095E-6 3.372E-5 1.228E-4 9 43
30 MP:0010948 abnormal double-strand DNA break repair 5.800E-8 4.095E-6 3.372E-5 1.228E-4 9 43
31 MP:0011704 decreased fibroblast proliferation 6.524E-8 4.457E-6 3.671E-5 1.382E-4 14 127
32 MP:0002018 increased malignant tumor incidence 9.295E-8 6.152E-6 5.067E-5 1.969E-4 24 382
33 MP:0013504 increased embryonic tissue cell apoptosis 2.442E-7 1.567E-5 1.291E-4 5.172E-4 14 141
34 MP:0001730 embryonic growth arrest 5.536E-7 3.448E-5 2.840E-4 1.172E-3 20 303
35 MP:0010288 increased gland tumor incidence 7.136E-7 4.318E-5 3.556E-4 1.511E-3 19 280
36 MP:0004029 spontaneous chromosome breakage 8.278E-7 4.870E-5 4.011E-4 1.753E-3 7 30
37 MP:0004957 abnormal blastocyst morphology 1.031E-6 5.748E-5 4.734E-4 2.184E-3 16 207
38 MP:0014137 abnormal preimplantation embryo morphology 1.031E-6 5.748E-5 4.734E-4 2.184E-3 16 207
39 MP:0005169 abnormal male meiosis 1.443E-6 7.834E-5 6.452E-4 3.055E-3 14 163
40 MP:0001930 abnormal meiosis 2.271E-6 1.203E-4 9.905E-4 4.811E-3 15 194
41 MP:0008057 abnormal DNA replication 3.383E-6 1.748E-4 1.439E-3 7.165E-3 6 24
42 MP:0010293 increased integument system tumor incidence 1.096E-5 5.526E-4 4.551E-3 2.321E-2 13 168
43 MP:0010299 increased mammary gland tumor incidence 1.274E-5 6.276E-4 5.169E-3 2.699E-2 10 100
44 MP:0010365 increased thymus tumor incidence 1.657E-5 7.845E-4 6.461E-3 3.510E-2 10 103
45 MP:0004045 abnormal cell cycle checkpoint function 1.668E-5 7.845E-4 6.461E-3 3.533E-2 8 63
46 MP:0002777 absent ovarian follicles 1.704E-5 7.845E-4 6.461E-3 3.609E-2 7 46
47 MP:0004815 abnormal somatic hypermutation frequency 1.768E-5 7.966E-4 6.561E-3 3.744E-2 5 19
48 MP:0009797 abnormal mismatch repair 2.030E-5 8.959E-4 7.378E-3 4.300E-2 4 10
49 MP:0003992 increased mortality induced by ionizing radiation 2.273E-5 9.827E-4 8.093E-3 4.815E-2 7 48
50 MP:0001147 small testis 2.345E-5 9.935E-4 8.182E-3 4.968E-2 23 488
Show 45 more annotations

6: Domain [Display Chart] 1414 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS50051 MCM 2 PROSITE 1.048E-12 3.704E-10 2.901E-9 1.481E-9 7 8
2 IPR033762 MCM OB InterPro 1.048E-12 3.704E-10 2.901E-9 1.481E-9 7 8
3 PF17207 MCM OB Pfam 1.048E-12 3.704E-10 2.901E-9 1.481E-9 7 8
4 PS00847 MCM 1 PROSITE 1.048E-12 3.704E-10 2.901E-9 1.481E-9 7 8
5 SM00350 MCM SMART 4.656E-12 8.229E-10 6.445E-9 6.584E-9 7 9
6 PF00493 MCM Pfam 4.656E-12 8.229E-10 6.445E-9 6.584E-9 7 9
7 IPR001208 MCM dom InterPro 4.656E-12 8.229E-10 6.445E-9 6.584E-9 7 9
8 IPR031327 MCM InterPro 4.656E-12 8.229E-10 6.445E-9 6.584E-9 7 9
9 IPR018525 MCM CS InterPro 9.268E-12 1.191E-9 9.331E-9 1.311E-8 6 6
10 IPR027925 MCM N InterPro 9.268E-12 1.191E-9 9.331E-9 1.311E-8 6 6
11 PF14551 MCM N Pfam 9.268E-12 1.191E-9 9.331E-9 1.311E-8 6 6
12 SM00382 AAA SMART 3.231E-9 3.372E-7 2.641E-6 4.568E-6 15 144
13 IPR003593 AAA+ ATPase InterPro 3.231E-9 3.372E-7 2.641E-6 4.568E-6 15 144
14 IPR012340 NA-bd OB-fold InterPro 3.339E-9 3.372E-7 2.641E-6 4.721E-6 12 84
15 PF00004 AAA Pfam 5.700E-8 5.373E-6 4.208E-5 8.059E-5 9 52
16 IPR003959 ATPase AAA core InterPro 8.031E-8 7.097E-6 5.558E-5 1.136E-4 9 54
17 IPR008921 DNA pol3 clamp-load cplx C InterPro 6.561E-7 5.458E-5 4.274E-4 9.278E-4 4 6
18 IPR021151 GINS complex InterPro 3.095E-6 2.084E-4 1.632E-3 4.376E-3 3 3
19 IPR013748 Rep factorC C InterPro 3.095E-6 2.084E-4 1.632E-3 4.376E-3 3 3
20 PF05916 Sld5 Pfam 3.095E-6 2.084E-4 1.632E-3 4.376E-3 3 3
21 PF08542 Rep fac C Pfam 3.095E-6 2.084E-4 1.632E-3 4.376E-3 3 3
22 PF00533 BRCT Pfam 6.342E-6 4.076E-4 3.192E-3 8.967E-3 5 19
23 IPR004039 Rubredoxin-type fold InterPro 1.224E-5 7.214E-4 5.649E-3 1.731E-2 3 4
24 2.20.28.10 - Gene3D 1.224E-5 7.214E-4 5.649E-3 1.731E-2 3 4
25 SM00292 BRCT SMART 1.386E-5 7.837E-4 6.137E-3 1.959E-2 5 22
26 3.40.50.10190 - Gene3D 1.749E-5 9.514E-4 7.451E-3 2.474E-2 5 23
27 PS50172 BRCT PROSITE 3.299E-5 1.728E-3 1.353E-2 4.665E-2 5 26
28 IPR001357 BRCT dom InterPro 4.813E-5 2.430E-3 1.903E-2
6.805E-2
 5 28
29 PF08423 Rad51 Pfam 1.037E-4 4.312E-3 3.377E-2
1.466E-1
 3 7
30 PS50162 RECA 2 PROSITE 1.037E-4 4.312E-3 3.377E-2
1.466E-1
 3 7
31 IPR013632 DNA recomb/repair Rad51 C InterPro 1.037E-4 4.312E-3 3.377E-2
1.466E-1
 3 7
32 PF06839 zf-GRF Pfam 1.037E-4 4.312E-3 3.377E-2
1.466E-1
 3 7
33 IPR020588 RecA ATP-bd InterPro 1.037E-4 4.312E-3 3.377E-2
1.466E-1
 3 7
34 IPR010666 Znf GRF InterPro 1.037E-4 4.312E-3 3.377E-2
1.466E-1
 3 7
35 IPR018866 Znf-4CXXC R1 InterPro 2.131E-4 7.727E-3
6.052E-2
3.014E-1
 2 2
36 IPR015163 Cdc6 C InterPro 2.131E-4 7.727E-3
6.052E-2
3.014E-1
 2 2
37 PF09079 Cdc6 C Pfam 2.131E-4 7.727E-3
6.052E-2
3.014E-1
 2 2
38 SM01074 Cdc6 C SMART 2.131E-4 7.727E-3
6.052E-2
3.014E-1
 2 2
39 PF10497 zf-4CXXC R1 Pfam 2.131E-4 7.727E-3
6.052E-2
3.014E-1
 2 2
40 1.10.10.10 - Gene3D 3.812E-4 1.348E-2
1.055E-1
5.391E-1
 11 218
41 PF02319 E2F TDP Pfam 4.680E-4 1.539E-2
1.205E-1
6.618E-1
 3 11
42 IPR003316 E2F WHTH DNA-bd dom InterPro 4.680E-4 1.539E-2
1.205E-1
6.618E-1
 3 11
43 SM01372 E2F TDP SMART 4.680E-4 1.539E-2
1.205E-1
6.618E-1
 3 11
44 3.30.420.10 - Gene3D 5.989E-4 1.571E-2
1.230E-1
8.469E-1
 5 47
45 IPR004365 NA-bd OB tRNA InterPro 6.173E-4 1.571E-2
1.230E-1
8.728E-1
 3 12
46 PF01336 tRNA anti-codon Pfam 6.173E-4 1.571E-2
1.230E-1
8.728E-1
 3 12
47 PF01624 MutS I Pfam 6.332E-4 1.571E-2
1.230E-1
8.953E-1
 2 3
48 PF04042 DNA pol E B Pfam 6.332E-4 1.571E-2
1.230E-1
8.953E-1
 2 3
49 IPR007185 DNA pol alpha/epsilon bsu InterPro 6.332E-4 1.571E-2
1.230E-1
8.953E-1
 2 3
50 IPR018982 RQC domain InterPro 6.332E-4 1.571E-2
1.230E-1
8.953E-1
 2 3
Show 45 more annotations

7: Pathway [Display Chart] 785 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 105765 Cell Cycle, Mitotic BioSystems: REACTOME 1.713E-66 1.345E-63 9.740E-63 1.345E-63 83 416
2 920977 RB in Cancer BioSystems: WikiPathways 4.801E-51 1.884E-48 1.365E-47 3.768E-48 42 87
3 105789 DNA strand elongation BioSystems: REACTOME 4.579E-44 1.067E-41 7.726E-41 3.595E-41 27 31
4 198771 DNA Replication BioSystems: WikiPathways 5.435E-44 1.067E-41 7.726E-41 4.267E-41 30 42
5 105897 DNA Replication BioSystems: REACTOME 5.297E-40 8.316E-38 6.023E-37 4.158E-37 38 106
6 105782 S Phase BioSystems: REACTOME 5.485E-37 7.176E-35 5.198E-34 4.306E-34 38 124
7 105777 Activation of the pre-replicative complex BioSystems: REACTOME 9.109E-37 1.021E-34 7.399E-34 7.150E-34 24 31
8 83039 DNA replication BioSystems: KEGG 3.127E-36 3.069E-34 2.223E-33 2.455E-33 25 36
9 105754 Activation of ATR in response to replication stress BioSystems: REACTOME 2.733E-35 2.384E-33 1.727E-32 2.146E-32 25 38
10 160941 Mitotic G1-G1/S phases BioSystems: REACTOME 7.237E-35 5.681E-33 4.115E-32 5.681E-32 38 139
11 105750 G2/M Checkpoints BioSystems: REACTOME 1.785E-34 1.274E-32 9.225E-32 1.401E-31 26 45
12 105784 Synthesis of DNA BioSystems: REACTOME 7.172E-34 4.691E-32 3.398E-31 5.630E-31 33 97
13 105769 G1/S Transition BioSystems: REACTOME 1.670E-31 1.008E-29 7.303E-29 1.311E-28 33 112
14 106543 Telomere C-strand (Lagging Strand) Synthesis BioSystems: REACTOME 1.418E-28 7.953E-27 5.761E-26 1.113E-25 18 22
15 161048 Chromosome Maintenance BioSystems: REACTOME 6.088E-27 3.186E-25 2.308E-24 4.779E-24 31 126
16 105820 M/G1 Transition BioSystems: REACTOME 1.405E-25 6.489E-24 4.701E-23 1.103E-22 26 84
17 105898 DNA Replication Pre-Initiation BioSystems: REACTOME 1.405E-25 6.489E-24 4.701E-23 1.103E-22 26 84
18 106541 Extension of Telomeres BioSystems: REACTOME 2.315E-25 1.010E-23 7.312E-23 1.817E-22 18 28
19 198805 G1 to S cell cycle control BioSystems: WikiPathways 2.938E-25 1.214E-23 8.791E-23 2.306E-22 24 68
20 105793 Lagging Strand Synthesis BioSystems: REACTOME 3.387E-25 1.329E-23 9.630E-23 2.659E-22 16 20
21 105739 Cell Cycle Checkpoints BioSystems: REACTOME 2.802E-23 1.047E-21 7.586E-21 2.199E-20 28 124
22 105837 DNA Repair BioSystems: REACTOME 6.750E-22 2.306E-20 1.670E-19 5.299E-19 26 113
23 377262 Fanconi anemia pathway BioSystems: KEGG 6.755E-22 2.306E-20 1.670E-19 5.303E-19 20 53
24 198811 Cell cycle BioSystems: WikiPathways 8.024E-22 2.625E-20 1.901E-19 6.299E-19 25 102
25 105790 Unwinding of DNA BioSystems: REACTOME 5.296E-20 1.663E-18 1.205E-17 4.158E-17 11 11
26 105778 E2F mediated regulation of DNA replication BioSystems: REACTOME 1.234E-19 3.726E-18 2.699E-17 9.689E-17 16 34
27 105794 Processive synthesis on the lagging strand BioSystems: REACTOME 3.940E-19 1.146E-17 8.298E-17 3.093E-16 12 15
28 137934 E2F transcription factor network BioSystems: Pathway Interaction Database 1.048E-18 2.938E-17 2.128E-16 8.226E-16 20 73
29 105888 Gap-filling DNA repair synthesis and ligation in GG-NER BioSystems: REACTOME 1.551E-18 4.059E-17 2.940E-16 1.218E-15 12 16
30 105893 Gap-filling DNA repair synthesis and ligation in TC-NER BioSystems: REACTOME 1.551E-18 4.059E-17 2.940E-16 1.218E-15 12 16
31 PW:0000662 mismatch repair pathway Pathway Ontology 2.098E-18 5.313E-17 3.849E-16 1.647E-15 14 26
32 106540 Telomere Maintenance BioSystems: REACTOME 4.463E-18 1.095E-16 7.930E-16 3.503E-15 20 78
33 83045 Mismatch repair BioSystems: KEGG 1.512E-17 3.597E-16 2.606E-15 1.187E-14 13 23
34 105795 Removal of the Flap Intermediate BioSystems: REACTOME 1.838E-17 4.245E-16 3.075E-15 1.443E-14 11 14
35 83054 Cell cycle BioSystems: KEGG 3.084E-17 6.917E-16 5.010E-15 2.421E-14 23 124
36 105889 Repair synthesis of patch ~27-30 bases long by DNA polymerase BioSystems: REACTOME 6.786E-17 1.440E-15 1.043E-14 5.327E-14 11 15
37 105894 Repair synthesis for gap-filling by DNA polymerase in TC-NER BioSystems: REACTOME 6.786E-17 1.440E-15 1.043E-14 5.327E-14 11 15
38 83046 Homologous recombination BioSystems: KEGG 4.571E-16 9.443E-15 6.840E-14 3.588E-13 13 28
39 105776 G1/S-Specific Transcription BioSystems: REACTOME 1.509E-15 3.037E-14 2.200E-13 1.184E-12 11 18
40 105791 Leading Strand Synthesis BioSystems: REACTOME 2.887E-15 5.396E-14 3.909E-13 2.266E-12 10 14
41 106545 Polymerase switching on the C-strand of the telomere BioSystems: REACTOME 2.887E-15 5.396E-14 3.909E-13 2.266E-12 10 14
42 105792 Polymerase switching BioSystems: REACTOME 2.887E-15 5.396E-14 3.909E-13 2.266E-12 10 14
43 105884 Global Genomic NER (GG-NER) BioSystems: REACTOME 1.030E-14 1.880E-13 1.362E-12 8.085E-12 13 34
44 105812 M Phase BioSystems: REACTOME 7.509E-14 1.340E-12 9.704E-12 5.895E-11 26 232
45 105815 Mitotic Prometaphase BioSystems: REACTOME 1.105E-13 1.928E-12 1.396E-11 8.675E-11 19 112
46 M6682 CDK Regulation of DNA Replication MSigDB C2 BIOCARTA (v5.1) 1.185E-13 2.022E-12 1.465E-11 9.301E-11 10 18
47 83044 Nucleotide excision repair BioSystems: KEGG 1.270E-12 2.121E-11 1.537E-10 9.970E-10 13 47
48 137959 BARD1 signaling events BioSystems: Pathway Interaction Database 1.378E-12 2.253E-11 1.632E-10 1.082E-9 11 29
49 106546 Processive synthesis on the C-strand of the telomere BioSystems: REACTOME 1.603E-12 2.568E-11 1.860E-10 1.258E-9 8 11
50 105863 Homologous recombination repair of replication-independent double-strand breaks BioSystems: REACTOME 1.817E-12 2.797E-11 2.026E-10 1.426E-9 9 16
Show 45 more annotations

8: Pubmed [Display Chart] 27408 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12791985 Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Pubmed 8.210E-45 2.250E-40 2.429E-39 2.250E-40 23 34
2 19237606:gr Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. GeneRIF 1.040E-40 9.502E-37 1.026E-35 2.851E-36 27 84
3 19237606 Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. Pubmed 1.040E-40 9.502E-37 1.026E-35 2.851E-36 27 84
4 15707391 DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. Pubmed 2.601E-32 1.782E-28 1.924E-27 7.130E-28 16 22
5 20496165:gr Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. GeneRIF 1.807E-31 8.256E-28 8.913E-27 4.954E-27 21 68
6 20496165 Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. Pubmed 1.807E-31 8.256E-28 8.913E-27 4.954E-27 21 68
7 15226314 Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures. Pubmed 2.659E-31 1.041E-27 1.124E-26 7.288E-27 15 19
8 20522537:gr Variation within DNA repair pathway genes and risk of multiple sclerosis. GeneRIF 1.020E-30 3.105E-27 3.353E-26 2.795E-26 21 73
9 20522537 Variation within DNA repair pathway genes and risk of multiple sclerosis. Pubmed 1.020E-30 3.105E-27 3.353E-26 2.795E-26 21 73
10 15232106 Self-assembling protein microarrays. Pubmed 4.878E-29 1.337E-25 1.443E-24 1.337E-24 16 30
11 12614612 Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. Pubmed 2.179E-28 5.428E-25 5.860E-24 5.971E-24 15 25
12 24958773 SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination. Pubmed 1.527E-27 3.487E-24 3.764E-23 4.184E-23 14 21
13 12045100 DNA replication in eukaryotic cells. Pubmed 2.197E-26 4.632E-23 5.001E-22 6.021E-22 13 18
14 19714462:gr Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. GeneRIF 6.651E-26 1.215E-22 1.312E-21 1.823E-21 15 33
15 19714462 Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. Pubmed 6.651E-26 1.215E-22 1.312E-21 1.823E-21 15 33
16 9111189 Which DNA polymerases are used for DNA-repair in eukaryotes? Pubmed 9.037E-25 1.548E-21 1.671E-20 2.477E-20 12 16
17 22540012 Interactions of the human MCM-BP protein with MCM complex components and Dbf4. Pubmed 1.161E-24 1.767E-21 1.908E-20 3.181E-20 11 12
18 24299456 Interaction of human minichromosome maintenance protein-binding protein with minichromosome maintenance 2-7. Pubmed 1.161E-24 1.767E-21 1.908E-20 3.181E-20 11 12
19 12171929 A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. Pubmed 3.318E-24 4.786E-21 5.167E-20 9.093E-20 14 31
20 19064572 Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. Pubmed 7.520E-24 9.814E-21 1.060E-19 2.061E-19 22 170
21 19064572:gr Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. GeneRIF 7.520E-24 9.814E-21 1.060E-19 2.061E-19 22 170
22 18270339 Comprehensive analysis of DNA repair gene variants and risk of meningioma. Pubmed 1.705E-23 2.032E-20 2.194E-19 4.674E-19 16 57
23 18270339:gr Comprehensive analysis of DNA repair gene variants and risk of meningioma. GeneRIF 1.705E-23 2.032E-20 2.194E-19 4.674E-19 16 57
24 24332808 PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Pubmed 2.924E-23 3.340E-20 3.605E-19 8.015E-19 27 340
25 15635413 Nucleolar proteome dynamics. Pubmed 3.195E-23 3.503E-20 3.782E-19 8.757E-19 29 419
26 19135898 Purification of proteins associated with specific genomic Loci. Pubmed 4.116E-23 4.339E-20 4.684E-19 1.128E-18 17 75
27 26527279 Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. Pubmed 9.503E-22 9.647E-19 1.041E-17 2.605E-17 21 182
28 11095689 The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. Pubmed 2.991E-21 2.928E-18 3.161E-17 8.198E-17 11 18
29 10846177 Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks. Pubmed 3.544E-21 3.349E-18 3.616E-17 9.713E-17 9 9
30 11931757 Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. Pubmed 4.571E-21 4.176E-18 4.508E-17 1.253E-16 12 26
31 26299517 The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression. Pubmed 1.651E-20 1.460E-17 1.576E-16 4.526E-16 16 84
32 10436018 The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells. Pubmed 5.452E-20 4.670E-17 5.041E-16 1.494E-15 10 15
33 19690177 Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. Pubmed 6.521E-20 5.256E-17 5.675E-16 1.787E-15 12 31
34 19690177:gr Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. GeneRIF 6.521E-20 5.256E-17 5.675E-16 1.787E-15 12 31
35 11473323 RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes. Pubmed 7.687E-19 5.963E-16 6.437E-15 2.107E-14 9 12
36 20301575 Fanconi Anemia Pubmed 7.832E-19 5.963E-16 6.437E-15 2.147E-14 10 18
37 20453000 A Large-scale genetic association study of esophageal adenocarcinoma risk. Pubmed 4.055E-18 2.925E-15 3.158E-14 1.111E-13 23 351
38 20453000:gr A Large-scale genetic association study of esophageal adenocarcinoma risk. GeneRIF 4.055E-18 2.925E-15 3.158E-14 1.111E-13 23 351
39 9822671 Replication factor C disengages from proliferating cell nuclear antigen (PCNA) upon sliding clamp formation, and PCNA itself tethers DNA polymerase delta to DNA. Pubmed 6.029E-18 4.131E-15 4.460E-14 1.652E-13 8 9
40 21149733 L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability. Pubmed 6.029E-18 4.131E-15 4.460E-14 1.652E-13 8 9
41 19692168 Genetic susceptibility to distinct bladder cancer subphenotypes. Pubmed 1.890E-17 1.234E-14 1.332E-13 5.181E-13 24 422
42 19692168:gr Genetic susceptibility to distinct bladder cancer subphenotypes. GeneRIF 1.890E-17 1.234E-14 1.332E-13 5.181E-13 24 422
43 16622419 The human CENP-A centromeric nucleosome-associated complex. Pubmed 5.181E-17 3.302E-14 3.565E-13 1.420E-12 11 36
44 18950845:gr Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. GeneRIF 6.115E-17 3.809E-14 4.112E-13 1.676E-12 14 88
45 18950845 Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. Pubmed 7.221E-17 4.398E-14 4.748E-13 1.979E-12 14 89
46 19584272:gr Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers. GeneRIF 1.095E-16 6.385E-14 6.893E-13 3.001E-12 8 11
47 19584272 Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers. Pubmed 1.095E-16 6.385E-14 6.893E-13 3.001E-12 8 11
48 16899510 Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. Pubmed 1.273E-16 7.123E-14 7.690E-13 3.490E-12 7 7
49 17296731 Identification and characterization of a novel component of the human minichromosome maintenance complex. Pubmed 1.273E-16 7.123E-14 7.690E-13 3.490E-12 7 7
50 20574454:gr Polymorphisms in the base excision repair pathway and graft-versus-host disease. GeneRIF 1.447E-16 7.625E-14 8.231E-13 3.965E-12 10 27
Show 45 more annotations

9: Interaction [Display Chart] 5653 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PCNA PCNA interactions 6.623E-34 3.744E-30 3.451E-29 3.744E-30 48 295
2 int:POLA1 POLA1 interactions 2.758E-27 7.796E-24 7.185E-23 1.559E-23 23 54
3 int:RPA1 RPA1 interactions 2.125E-26 4.004E-23 3.691E-22 1.201E-22 50 470
4 int:MCM6 MCM6 interactions 8.139E-26 1.150E-22 1.060E-21 4.601E-22 26 88
5 int:MCM3 MCM3 interactions 3.955E-25 4.471E-22 4.121E-21 2.236E-21 28 115
6 int:MCM4 MCM4 interactions 7.561E-24 7.124E-21 6.566E-20 4.274E-20 25 92
7 int:MSH2 MSH2 interactions 1.306E-21 1.055E-18 9.725E-18 7.385E-18 26 124
8 int:BLM BLM interactions 1.963E-21 1.387E-18 1.279E-17 1.110E-17 25 113
9 int:MCM7 MCM7 interactions 4.378E-21 2.750E-18 2.535E-17 2.475E-17 28 158
10 int:CDC7 CDC7 interactions 9.322E-21 5.270E-18 4.857E-17 5.270E-17 16 32
11 int:DBF4 DBF4 interactions 2.279E-20 1.171E-17 1.080E-16 1.288E-16 14 22
12 int:CDK1 CDK1 interactions 1.840E-19 8.667E-17 7.988E-16 1.040E-15 33 270
13 int:MRE11 MRE11 interactions 7.676E-19 3.338E-16 3.077E-15 4.339E-15 23 114
14 int:RFC1 RFC1 interactions 2.190E-18 8.844E-16 8.152E-15 1.238E-14 19 70
15 int:ATR ATR interactions 2.928E-18 1.103E-15 1.017E-14 1.655E-14 22 107
16 int:MSH6 MSH6 interactions 4.709E-18 1.664E-15 1.534E-14 2.662E-14 20 84
17 int:E2F4 E2F4 interactions 8.305E-18 2.762E-15 2.545E-14 4.695E-14 22 112
18 int:ATM ATM interactions 9.915E-18 3.114E-15 2.870E-14 5.605E-14 26 174
19 int:ORC2 ORC2 interactions 1.180E-17 3.510E-15 3.236E-14 6.670E-14 18 65
20 int:FANCD2 FANCD2 interactions 3.848E-17 1.088E-14 1.002E-13 2.175E-13 18 69
21 int:RPA2 RPA2 interactions 5.929E-17 1.596E-14 1.471E-13 3.352E-13 38 443
22 int:E2F1 E2F1 interactions 6.969E-17 1.791E-14 1.651E-13 3.940E-13 24 154
23 int:CDC45 CDC45 interactions 2.201E-16 5.411E-14 4.987E-13 1.244E-12 14 36
24 int:ORC1 ORC1 interactions 2.365E-16 5.570E-14 5.134E-13 1.337E-12 16 54
25 int:GINS3 GINS3 interactions 1.338E-15 3.026E-13 2.789E-12 7.566E-12 13 32
26 int:RFC2 RFC2 interactions 1.535E-15 3.338E-13 3.076E-12 8.678E-12 16 60
27 int:FEN1 FEN1 interactions 2.050E-15 4.293E-13 3.957E-12 1.159E-11 16 61
28 int:RAD51 RAD51 interactions 2.269E-15 4.581E-13 4.223E-12 1.283E-11 20 113
29 int:HIST1H2BG HIST1H2BG interactions 4.316E-15 8.414E-13 7.755E-12 2.440E-11 26 222
30 int:TIMELESS TIMELESS interactions 1.304E-14 2.458E-12 2.265E-11 7.373E-11 12 29
31 int:RAD21 RAD21 interactions 2.080E-14 3.793E-12 3.496E-11 1.176E-10 27 258
32 int:NBN NBN interactions 3.579E-14 6.322E-12 5.827E-11 2.023E-10 17 85
33 int:RPA3 RPA3 interactions 3.715E-14 6.365E-12 5.866E-11 2.100E-10 32 381
34 int:CCNA2 CCNA2 interactions 5.079E-14 8.444E-12 7.783E-11 2.871E-10 19 116
35 int:HIST1H3A HIST1H3A interactions 6.356E-14 1.027E-11 9.462E-11 3.593E-10 27 270
36 int:CHTF18 CHTF18 interactions 7.388E-14 1.160E-11 1.069E-10 4.176E-10 11 25
37 int:TIPIN TIPIN interactions 1.490E-13 2.226E-11 2.052E-10 8.422E-10 9 14
38 int:CHAF1A CHAF1A interactions 1.496E-13 2.226E-11 2.052E-10 8.460E-10 24 215
39 int:CCNE1 CCNE1 interactions 2.059E-13 2.985E-11 2.751E-10 1.164E-9 16 80
40 int:HIST1H3E HIST1H3E interactions 2.893E-13 4.089E-11 3.769E-10 1.636E-9 23 201
41 int:GINS1 GINS1 interactions 3.100E-13 4.274E-11 3.940E-10 1.752E-9 7 7
42 int:CENPS CENPS interactions 6.940E-13 9.340E-11 8.609E-10 3.923E-9 10 22
43 int:GINS4 GINS4 interactions 8.416E-13 1.090E-10 1.005E-9 4.757E-9 11 30
44 int:ORC5 ORC5 interactions 8.487E-13 1.090E-10 1.005E-9 4.798E-9 12 39
45 int:HIST1H4A HIST1H4A interactions 9.969E-13 1.252E-10 1.154E-9 5.635E-9 20 154
46 int:CDT1 CDT1 interactions 1.150E-12 1.413E-10 1.302E-9 6.499E-9 14 62
47 int:ORC6 ORC6 interactions 1.930E-12 2.273E-10 2.095E-9 1.091E-8 11 32
48 int:MSH3 MSH3 interactions 1.930E-12 2.273E-10 2.095E-9 1.091E-8 11 32
49 int:MCM10 MCM10 interactions 3.089E-12 3.564E-10 3.285E-9 1.746E-8 13 54
50 int:USP37 USP37 interactions 3.995E-12 4.517E-10 4.163E-9 2.258E-8 16 96
Show 45 more annotations

10: Cytoband [Display Chart] 238 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1p32 1p32 6.318E-5 1.504E-2
9.100E-2
 1.504E-2 4 27
2 7p15-p14 7p15-p14 3.860E-4 4.593E-2
2.780E-1
9.187E-2
 2 4

11: Transcription Factor Binding Site [Display Chart] 421 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$E2F Q6 V$E2F Q6 8.077E-37 2.755E-34 1.824E-33 3.401E-34 41 182
2 V$E2F Q4 V$E2F Q4 1.309E-36 2.755E-34 1.824E-33 5.510E-34 41 184
3 V$E2F4DP1 01 V$E2F4DP1 01 2.144E-33 3.009E-31 1.992E-30 9.027E-31 39 189
4 V$E2F1 Q6 V$E2F1 Q6 7.952E-33 8.370E-31 5.542E-30 3.348E-30 38 181
5 V$E2F4DP2 01 V$E2F4DP2 01 1.543E-32 9.279E-31 6.144E-30 6.495E-30 38 184
6 V$E2F1DP1 01 V$E2F1DP1 01 1.543E-32 9.279E-31 6.144E-30 6.495E-30 38 184
7 V$E2F1DP2 01 V$E2F1DP2 01 1.543E-32 9.279E-31 6.144E-30 6.495E-30 38 184
8 V$E2F 03 V$E2F 03 6.901E-32 3.631E-30 2.404E-29 2.905E-29 38 191
9 V$E2F1DP1RB 01 V$E2F1DP1RB 01 3.235E-31 1.362E-29 9.017E-29 1.362E-28 37 184
10 V$E2F 02 V$E2F 02 3.235E-31 1.362E-29 9.017E-29 1.362E-28 37 184
11 V$E2F Q6 01 V$E2F Q6 01 6.503E-30 2.489E-28 1.648E-27 2.738E-27 36 184
12 V$E2F1 Q3 V$E2F1 Q3 2.175E-29 7.629E-28 5.051E-27 9.155E-27 36 190
13 V$E2F Q4 01 V$E2F Q4 01 1.527E-28 4.944E-27 3.274E-26 6.428E-26 35 185
14 V$E2F Q3 V$E2F Q3 5.868E-28 1.765E-26 1.168E-25 2.470E-25 34 177
15 V$E2F Q3 01 V$E2F Q3 01 3.383E-27 9.494E-26 6.286E-25 1.424E-24 34 186
16 SGCGSSAAA V$E2F1DP2 01 SGCGSSAAA V$E2F1DP2 01 4.154E-27 1.093E-25 7.236E-25 1.749E-24 30 131
17 V$E2F1 Q6 01 V$E2F1 Q6 01 5.933E-27 1.469E-25 9.728E-25 2.498E-24 34 189
18 V$E2F1 Q4 01 V$E2F1 Q4 01 2.333E-26 5.457E-25 3.613E-24 9.823E-24 33 181
19 V$E2F1 Q4 V$E2F1 Q4 1.491E-12 3.304E-11 2.188E-10 6.278E-10 21 189
20 KTGGYRSGAA UNKNOWN KTGGYRSGAA UNKNOWN 1.826E-12 3.845E-11 2.546E-10 7.689E-10 13 55
21 V$E2F 01 V$E2F 01 6.872E-10 1.378E-8 9.122E-8 2.893E-7 11 55
22 V$E2F1 Q3 01 V$E2F1 Q3 01 1.562E-5 2.989E-4 1.979E-3 6.575E-3 13 200
23 ACTAYRNNNCCCR UNKNOWN ACTAYRNNNCCCR UNKNOWN 1.614E-3 2.955E-2
1.956E-1
6.796E-1
 13 320
Show 18 more annotations

12: Gene Family [Display Chart] 104 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 548 Fanconi anemia complementation groups genenames.org 1.946E-20 2.023E-18 1.058E-17 2.023E-18 12 20
2 1085 MCM family genenames.org 1.381E-13 7.184E-12 3.754E-11 1.437E-11 7 9
3 1335 Ankyrin repeat domain containing|BRCA1 B complex genenames.org 6.057E-9 1.575E-7 8.231E-7 6.300E-7 4 4
4 931 GINS complex genenames.org 6.057E-9 1.575E-7 8.231E-7 6.300E-7 4 4
5 413 AAA ATPases genenames.org 2.095E-8 4.358E-7 2.278E-6 2.179E-6 8 53
6 535 DNA polymerases genenames.org 4.045E-8 7.010E-7 3.664E-6 4.206E-6 6 23
7 1269 EF-hand domain containing|Nucleotide excision repair|Transcription and export complex 2 genenames.org 4.105E-7 5.361E-6 2.802E-5 4.269E-5 5 18
8 581 HAUS augmin like complex genenames.org 4.124E-7 5.361E-6 2.802E-5 4.289E-5 4 8
9 1336 Ring finger proteins|Fanconi anemia complementation groups|Protein phosphatase 1 regulatory subunits|BRCA1 A complex|BRCA1 B complex|BRCA1 C complex genenames.org 6.840E-6 7.904E-5 4.131E-4 7.113E-4 3 5
10 1051 Nucleoporins genenames.org 8.723E-6 9.072E-5 4.741E-4 9.072E-4 5 32
11 135 Zinc fingers GRF-type genenames.org 2.363E-5 2.234E-4 1.167E-3 2.457E-3 3 7
12 362 WD repeat domain containing genenames.org 1.227E-4 1.064E-3 5.559E-3 1.276E-2 10 262
13 1167 DNA helicases genenames.org 4.299E-4 3.439E-3 1.797E-2 4.471E-2 3 17
14 1026 MutS homologs genenames.org 7.742E-4 5.368E-3 2.805E-2
8.052E-2
 2 5
15 1049 RecQ like helicases genenames.org 7.742E-4 5.368E-3 2.805E-2
8.052E-2
 2 5
16 1050 Topoisomerases genenames.org 1.155E-3 6.670E-3 3.486E-2
1.201E-1
 2 6
17 960 Origin recognition complex genenames.org 1.155E-3 6.670E-3 3.486E-2
1.201E-1
 2 6
18 1347 Lysine methyltransferases|Myb/SANT domain containing|Polycomb repressive complex 2 genenames.org 1.155E-3 6.670E-3 3.486E-2
1.201E-1
 2 6
19 761 Structural maintenance of chromosomes proteins|Cohesin complex genenames.org 1.607E-3 8.795E-3 4.597E-2
1.671E-1
 2 7
20 982 E2F transcription factors genenames.org 2.130E-3 1.108E-2
5.789E-2
2.215E-1
 2 8
21 817 Exosome complex genenames.org 4.904E-3 2.318E-2
1.212E-1
5.101E-1
 2 12
22 573 Small leucine rich repeat proteoglycans genenames.org 4.904E-3 2.318E-2
1.212E-1
5.101E-1
 2 12
23 544 Exonucleases genenames.org 8.712E-3 3.858E-2
2.017E-1
9.060E-1
 2 16
24 1108 Myosins, class XIX genenames.org 8.904E-3 3.858E-2
2.017E-1
9.260E-1
 1 1
25 684 Zinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases genenames.org 9.816E-3 4.083E-2
2.134E-1
1.000E0
 2 17
26 870 Minor histocompatibility antigens genenames.org 1.056E-2 4.223E-2
2.207E-1
1.000E0
 3 51
27 498 WD repeat domain containing|DDB1 and CUL4 associated factors genenames.org 1.098E-2 4.229E-2
2.210E-1
1.000E0
 2 18
Show 22 more annotations

13: Coexpression [Display Chart] 5874 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2156 Genes up-regulated in MCF7 cells (breast cancer) at 24 h of estradiol [PubChemID=5757] treatment. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.898E-171 2.290E-167 2.119E-166 2.290E-167 131 324
2 M1915 Genes down-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.192E-136 3.501E-133 3.241E-132 7.002E-133 108 277
3 M16010 Genes down-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.916E-127 9.625E-124 8.909E-123 2.888E-123 100 251
4 M5925 Genes encoding cell cycle related targets of E2F transcription factors. MSigDB H: Hallmark Gene Sets (v5.1) 3.966E-95 5.824E-92 5.391E-91 2.330E-91 77 200
5 M2879 Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.651E-91 3.114E-88 2.882E-87 1.557E-87 88 342
6 M9516 Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA2 [GeneID=675] across a compendium of normal tissues. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.496E-85 2.443E-82 2.261E-81 1.466E-81 90 423
7 M1916 Genes down-regulated in neural stem cells (NSC) at both 36 h and 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.686E-80 1.414E-77 1.309E-76 9.901E-77 54 89
8 M14340 Genes down-regulated in MCF-7 cells (breast cancer) after knockdown of YBX1 [GeneID=4904] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.213E-75 8.905E-73 8.242E-72 7.124E-72 66 201
9 M15969 Cluster 1: genes up-regulated by RB1, CDNK2A [GeneID=1029;5925], and one of the E2Fs (E2F1, E2F2, or E2F3 [GeneID=1869;1870;1871]). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.709E-75 1.116E-72 1.033E-71 1.004E-71 48 70
10 GSE39556 CD8A DC VS NK CELL MOUSE 3H POST POLYIC INJ UP Genes up-regulated after poly(IC) injection: CD8A [GeneID=925] dendritic cells versus NK cells. MSigDB C7: Immunologic Signatures (v5.1) 3.996E-74 2.347E-71 2.173E-70 2.347E-70 65 200
11 M8520 Cluster 6 of method A: up-regulation of these genes in patients with non-small cell lung cancer (NSCLC) predicts poor survival outcome. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.063E-73 5.678E-71 5.255E-70 6.245E-70 84 456
12 M2132 Genes down-regulated in RS4;11 cells (MLL, mixed lineage leukemia) in response to SB216763 [PubChemID=176158], an inhibitor of GSK3B [GeneID=2932]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.242E-72 6.081E-70 5.628E-69 7.297E-69 78 374
13 M1913 Genes down-regulated in neural stem cells (NSC) at 36 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.562E-70 2.965E-67 2.744E-66 3.854E-66 61 185
14 M18562 Genes down-regulated in response to both hypoxia and overexpression of an active form of HIF1A [GeneID=3091]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.515E-68 1.055E-65 9.767E-65 1.477E-64 69 289
15 M18811 Genes constituting the XPRSS-Int network: intersection of genes whose expression correlates with BRCA1, BRCA2, ATM, and CHEK2 [GeneID=672;675;472;11200] in a compendium of normal tissues. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.440E-66 1.739E-63 1.609E-62 2.608E-62 57 168
16 M3580 Genes up-regulated in comparison of wild type CD8 effector T cells at day 6 versus those from mice defficient for TRAF6 [GeneID=7189] at day 10. MSigDB C7: Immunologic Signatures (v5.1) 2.944E-64 1.081E-61 1.000E-60 1.729E-60 59 200
17 M15664 The 'Cervical Cancer Proliferation Cluster' (CCPC): genes whose expression in cervical carcinoma positively correlates with that of the HPV E6 and E7 oncogenes; they are also differentially expressed according to disease outcome. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.149E-62 3.970E-60 3.675E-59 6.750E-59 52 140
18 M4288 Genes up-regulated in MCF10A cells (breast cancer) grown at low (mesenchymal phenotype) compared to those grown at high (epithelial, basal-like phenotype) confluency. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.990E-62 6.493E-60 6.010E-59 1.169E-58 56 180
19 M15305 Genes constituting the BRCA-centered network (BCN). MSigDB C2: CGP Curated Gene Sets (v5.1) 3.456E-62 1.068E-59 9.889E-59 2.030E-58 49 117
20 M11563 Genes involved in DNA repair, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.269E-60 9.602E-58 8.887E-57 1.920E-56 59 230
21 M19048 Genes down-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.760E-59 2.171E-56 2.009E-55 4.558E-55 50 142
22 M854 Genes whose expression profile is specific to Cluster III of urothelial cell carcinoma (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.452E-58 3.876E-56 3.588E-55 8.527E-55 65 328
23 GSE13547 CTRL VS ANTI IGM STIM BCELL 12H UP Genes up-regulated in B lymphocytes: control versus stimulated by anti-IgM for 12h. MSigDB C7: Immunologic Signatures (v5.1) 2.738E-57 6.993E-55 6.472E-54 1.608E-53 53 182
24 M1577 Strongly up-regulated at 16-24 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.803E-57 2.154E-54 1.994E-53 5.171E-53 44 101
25 M5198 Genes down-regulated in quiescent vs dividing CD34+ [GeneID=8842] cells isolated from peripheral blood of normal donors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.197E-56 2.812E-54 2.603E-53 7.031E-53 42 87
26 M3577 Genes up-regulated in comparison of wild type CD8 effector T cells at day 6 versus those at day 10. MSigDB C7: Immunologic Signatures (v5.1) 2.255E-56 5.095E-54 4.716E-53 1.325E-52 54 200
27 M2074 Genes periodically expressed in synchronized HeLa cells (cervical carcinoma), with peak during the G1/S phase of cell cycle. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.886E-56 6.278E-54 5.811E-53 1.695E-52 49 147
28 M11537 Fibroblast serum response genes showing periodic expression during the cell cycle; excluded from the core serum response signature. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.269E-56 8.956E-54 8.289E-53 2.508E-52 49 148
29 GSE18893 TCONV VS TREG 24H TNF STIM UP Genes up-regulated in lymphocytes treated with TNF [GeneID=7124] for 24h: T conv versus T reg cells. MSigDB C7: Immunologic Signatures (v5.1) 7.797E-55 1.579E-52 1.462E-51 4.580E-51 53 200
30 M4077 Genes identified by method 2 as coordinately down-regulated late in HMEC cells (mammary epithelium) during acinar development in vitro. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.367E-53 2.676E-51 2.477E-50 8.029E-50 58 277
31 M2606 Cell cycle genes significantly (p =< 0.05) changed in fibroblast cells at 6 h after exposure to ionizing radiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.261E-53 4.191E-51 3.879E-50 1.328E-49 40 85
32 M2257 Cellular genes up-regulated in forskin fibroblasts by expression of CMV EI86 protein off an adenovirus vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.283E-53 4.191E-51 3.879E-50 1.341E-49 36 60
33 M2431 DNA repair and replication genes up-regulated in melanoma patients who will relapse vs patients who will not. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.509E-53 9.807E-51 9.077E-50 3.236E-49 36 61
34 M7094 Genes down-regulated in adult fibroblasts with inactivated RB1 [GeneID=5925] by Cre-lox: acute loss of function (LOF) of RB1. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.767E-53 9.963E-51 9.222E-50 3.388E-49 54 228
35 M2075 Genes periodically expressed in synchronized HeLa cells (cervical carcinoma), with peak during the S phase of cell cycle. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.939E-52 4.933E-50 4.565E-49 1.726E-48 48 162
36 M5294 Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from young donors versus those treated with TSST at 72 h. MSigDB C7: Immunologic Signatures (v5.1) 2.691E-50 4.272E-48 3.954E-47 1.581E-46 50 200
37 M5300 Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from old donors versus those treated with TSST at 40 h. MSigDB C7: Immunologic Signatures (v5.1) 2.691E-50 4.272E-48 3.954E-47 1.581E-46 50 200
38 M3155 Genes up-regulated in quiescent CD34+ [GeneID=8842] cells isolated from peripheral blood of normal donors compared to the dividing cells from CML (chronic myeloid leukemia) patients. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.216E-49 1.880E-47 1.740E-46 7.142E-46 48 181
39 M19875 Genes up-regulated in nsopharyngeal carcinoma relative to the normal tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.882E-49 4.341E-47 4.017E-46 1.693E-45 56 294
40 GSE40274 CTRL VS FOXP3 TRANSDUCED ACTIVATED CD4 TCELL UP Genes up-regulated in CD4 T conv: control versus over-expression of FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v5.1) 8.241E-49 1.181E-46 1.093E-45 4.841E-45 49 200
41 GSE21063 WT VS NFATC1 KO 8H ANTI IGM STIM BCELL UP Genes up-regulated in B lymphocytes stimulated by anti-IgM for 8h: wildtype versus NFATC1 [GeneID=4772] knockout. MSigDB C7: Immunologic Signatures (v5.1) 8.241E-49 1.181E-46 1.093E-45 4.841E-45 49 200
42 M9372 Genes involved in DNA replication, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.857E-48 3.952E-46 3.658E-45 1.678E-44 44 146
43 M14985 Genes up-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [GeneID=4904] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.893E-48 3.952E-46 3.658E-45 1.699E-44 55 290
44 M5292 Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from young donors versus those treated with TSST at 40 h. MSigDB C7: Immunologic Signatures (v5.1) 2.446E-47 3.266E-45 3.023E-44 1.437E-43 48 200
45 M7854 Differentially expressed genes in a panel of xenografts representing 8 common pediatric tumors compared to the normal tissues. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.234E-46 1.611E-44 1.491E-43 7.250E-43 40 116
46 M5041 Genes up-regulated in comparison of splenic primary CD8 effector T cells at day 8 post-acute infection versus splenic secondary CD8 effector T cells at day 8 post-acute infection. MSigDB C7: Immunologic Signatures (v5.1) 5.442E-46 6.949E-44 6.432E-43 3.196E-42 47 199
47 M3766 Up-regulated genes whose expression correlated with histologic grade of invasive breast cancer tumors: comparison of grade 1 vs grade 3. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.735E-46 7.168E-44 6.634E-43 3.369E-42 43 151
48 M4604 Genes up-regulated in comparison of CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 7 versus CD25- T cells treated with IL4 [GeneID=3565] at day 7. MSigDB C7: Immunologic Signatures (v5.1) 7.038E-46 8.268E-44 7.653E-43 4.134E-42 47 200
49 GSE25088 WT VS STAT6 KO MACROPHAGE IL4 STIM DN Genes down-regulated in bone marrow-derived macrophages treated with IL4 [GeneID=3565]: wildtype versus STAT6 [GeneID=6778] knockout. MSigDB C7: Immunologic Signatures (v5.1) 7.038E-46 8.268E-44 7.653E-43 4.134E-42 47 200
50 GSE33292 WT VS TCF1 KO DN3 THYMOCYTE DN Genes down-regulated in DN3 thymocytes: wildtype versus TCF7 [GeneID=6932] knockout. MSigDB C7: Immunologic Signatures (v5.1) 7.038E-46 8.268E-44 7.653E-43 4.134E-42 47 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2033 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM399403 500 alpha beta T cells, T.ISP.Th, 4- 8+ TCR-/lo 24hi, Thymus, avg-3 Immgen.org, GSE15907 9.263E-148 1.883E-144 1.543E-143 1.883E-144 129 417
2 GSM399452 500 B cells, preB.FrC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-3 Immgen.org, GSE15907 4.824E-123 4.904E-120 4.018E-119 9.807E-120 114 409
3 GSM538387 500 alpha beta T cells, T.8Eff.Sp.OT1.d5.VSVOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 1.415E-119 9.587E-117 7.856E-116 2.876E-116 112 410
4 GSM538358 500 B cells, proB.FrBC.FL, CD19+ IgM- CD43+ CD24+ AA4.1+ CD45R+, Fetal Liver, avg-3 Immgen.org, GSE15907 4.669E-111 2.373E-108 1.945E-107 9.492E-108 106 400
5 GSM791143 500 alpha beta T cells, preT.DN3-4.Th, Lin-/lo CD25int CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 7.983E-110 3.246E-107 2.660E-106 1.623E-106 105 397
6 GSM791154 500 alpha beta T cells, T.DN4.Th, Lin-/lo CD25- CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 1.796E-104 6.086E-102 4.987E-101 3.652E-101 100 376
7 GSM538357 500 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 6.979E-99 2.027E-96 1.661E-95 1.419E-95 100 422
8 GSM791149 500 alpha beta T cells, preT.DN3B.Th, Lin-/lo CD25hi CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 2.300E-98 5.844E-96 4.789E-95 4.675E-95 99 413
9 GSM399397 500 alpha beta T cells, T.DPbl.Th, 4+ 8+ TCR-/lo FSChi, Thymus, avg-3 Immgen.org, GSE15907 6.891E-97 1.557E-94 1.276E-93 1.401E-93 97 399
10 GSM791141 500 alpha beta T cells, preT.DN2B.Th, Lin-/lo CD25hi CD44+ cKitint, Thymus, avg-2 Immgen.org, GSE15907 1.659E-94 3.373E-92 2.764E-91 3.373E-91 97 420
11 12Dn Top 500 All 12Dn Top 500 All Brain Map - Allen iN 2.845E-94 5.259E-92 4.309E-91 5.784E-91 102 495
12 fetal replicating Top 500 All fetal replicating Top 500 All Brain Map - Barres 3.551E-94 6.016E-92 4.930E-91 7.219E-91 102 496
13 GSM538348 500 B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-2 Immgen.org, GSE15907 4.407E-90 6.891E-88 5.647E-87 8.959E-87 94 419
14 GSM791136 500 alpha beta T cells, preT.DN2.Th, Lin-/lo CD25hi CD44+ cKit+, Thymus, avg-3 Immgen.org, GSE15907 5.626E-90 8.170E-88 6.695E-87 1.144E-86 94 420
15 GSM476664 500 gamma delta T cells, Tgd.vg3+24alo.e17.Th, TCRd+ Vg3+ CD24-, Fetal Thymus, avg-3 Immgen.org, GSE15907 1.377E-88 1.867E-86 1.530E-85 2.800E-85 93 419
16 GSM538355 500 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R+ CD, Fetal Liver, avg-2 Immgen.org, GSE15907 2.834E-88 3.602E-86 2.951E-85 5.763E-85 93 422
17 fetal replicating Top 500 Cluster 1 fetal replicating Top 500 Cluster 1 Brain Map - Barres 3.537E-87 4.230E-85 3.467E-84 7.192E-84 80 267
18 GSM538350 500 B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate CD45R- AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 2.972E-84 3.357E-82 2.751E-81 6.043E-81 90 418
19 12Dn Top 500 Cluster 4 12Dn Top 500 Cluster 4 Brain Map - Allen iN 3.297E-84 3.527E-82 2.891E-81 6.702E-81 61 117
20 GSM791105 500 Stem Cells, SC.MDP.BM, Sca1- Flt3+ MCSFR+ cKithi, Bone marrow, avg-3 Immgen.org, GSE15907 1.433E-78 1.456E-76 1.194E-75 2.913E-75 85 402
21 GSM476660 500 gamma delta T cells, Tgd.vg2+24ahi.e17.Th, TCRd+ Vg2+ CD24+, Fetal Thymus, avg-3 Immgen.org, GSE15907 5.604E-76 5.425E-74 4.445E-73 1.139E-72 84 414
22 Lungmap Mouse e16.5 Proliferative fibroblast Top 500 All Mouse Lung E16.5 Proliferative fibroblast top 500 Lungmap Mouse Single Cell (Lungmap.net) 5.906E-74 5.458E-72 4.473E-71 1.201E-70 85 452
23 GSM538207 500 B cells, B.GC.Sp, CD19+ IgM+ IgD- GL7+ PNA+, Spleen, avg-3 Immgen.org, GSE15907 1.535E-73 1.357E-71 1.112E-70 3.121E-70 80 380
24 GSM791108 500 Stem Cells, SC.MEP.BM, Lineage- Kit+ Sca1- CD34- FcgR-/low, Bone marrow, avg-2 Immgen.org, GSE15907 9.459E-69 8.013E-67 6.566E-66 1.923E-65 78 401
25 GSM791131 500 B cells, MLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-3 Immgen.org, GSE15907 4.951E-68 4.026E-66 3.299E-65 1.006E-64 79 425
26 GSM791114 500 Stem Cells, SC.CDP.BM, Sca1- Flt3+ MCSFR+ cKitlo, Bone marrow, avg-3 Immgen.org, GSE15907 2.276E-67 1.780E-65 1.458E-64 4.627E-64 77 401
27 gudmap dev gonad e11.5 M PrimGermCell Oct k2 1000 dev gonad e11.5 M PrimGermCell Oct k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 8.876E-65 6.683E-63 5.477E-62 1.805E-61 65 258
28 GSM538352 500 B cells, proB.FrA.BM, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Bone marrow, avg-2 Immgen.org, GSE15907 2.144E-64 1.557E-62 1.276E-61 4.359E-61 74 388
29 GSM791139 500 alpha beta T cells, preT.DN2A.Th, Lin-/lo CD25hi CD44+ cKithi, Thymus, avg-2 Immgen.org, GSE15907 5.869E-64 4.114E-62 3.372E-61 1.193E-60 75 409
30 GSM399450 500 B cells, proB.FrBC.BM, CD19+ IgM- CD43+ AA4.1+ CD45R+, Bone marrow, avg-2 Immgen.org, GSE15907 3.391E-63 2.224E-61 1.823E-60 6.894E-60 74 402
31 GSM605898 500 alpha beta T cells, T.8Eff.Sp.OT1.d6.LisOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 3.391E-63 2.224E-61 1.823E-60 6.894E-60 74 402
32 GSM605781 500 gamma delta T cells, Tgd.vg1+vd6-.Th, TCRd+ Vg1.1+, Thymus, avg-3 Immgen.org, GSE15907 2.938E-60 1.866E-58 1.529E-57 5.972E-57 70 373
33 Lungmap Mouse e16.5 Endothelial SubClass Proliferative Endothelial Top 500 All Mouse Lung E16.5 Proliferative Endothelial top500 Lungmap Mouse Single Cell (Lungmap.net) 5.070E-60 3.124E-58 2.560E-57 1.031E-56 74 442
34 GSM791124 500 B cells, MLP.BM, CD19- IgM- CD43+ CD24- AA4.1+ CD45R- CD117+ IL7R-, Bone marrow, avg-2 Immgen.org, GSE15907 6.120E-59 3.659E-57 2.999E-56 1.244E-55 72 422
35 GSM791134 500 alpha beta T cells, preT.DN2-3.Th, Lin-/lo CD25hi CD44Int, Thymus, avg-2 Immgen.org, GSE15907 7.078E-57 4.111E-55 3.369E-54 1.439E-53 70 415
36 gudmap dev gonad e12.5 M GermCellTestis Oct k2 1000 dev gonad e12.5 M GermCellTestis Oct k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.609E-56 9.085E-55 7.445E-54 3.271E-53 60 266
37 gudmap dev gonad e13.5 F MeioticGermCell Oct k2 1000 dev gonad e13.5 F MeioticGermCell Oct k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 6.522E-56 3.584E-54 2.937E-53 1.326E-52 66 361
38 GSM791122 500 Fetal Liver, SC.STSL.FL, IgM- CD24- CD117+ IL7R- CD150- CD48- AA4.1+ CD43+, Fetal Liver, avg-2 Immgen.org, GSE15907 7.045E-51 3.769E-49 3.089E-48 1.432E-47 65 410
39 gudmap kidney P3 CapMes Crym k4 1000 kidney P3 CapMes Crym k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.600E-50 1.355E-48 1.111E-47 5.286E-47 59 317
40 GSM476658 500 gamma delta T cells, Tgd.vg2-24ahi.Th, TCRd+ Vg2- CD24+, Thymus, avg-2 Immgen.org, GSE15907 4.765E-50 2.422E-48 1.985E-47 9.688E-47 65 422
41 GSM538340 500 B cells, preB.FrD.FL, AA4.1+ IgM- CD19+ CD43- CD24+, Fetal Liver, avg-3 Immgen.org, GSE15907 1.957E-49 9.703E-48 7.952E-47 3.978E-46 63 395
42 GSM538338 500 alpha beta T cells, NKT.44-NK1.1-.Th, aGC CD1d tet CD3e, Thymus, avg-2 Immgen.org, GSE15907 3.185E-49 1.542E-47 1.263E-46 6.474E-46 63 398
43 GSM538418 500 B cells, proB.FrBC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-1 Immgen.org, GSE15907 5.783E-47 2.734E-45 2.240E-44 1.176E-43 60 377
44 GSM538345 500 B cells, proB.CLP.BM, CD19- IgM- CD43+ CD24intermediate CD45R- AA4.1+ CD, Bone marrow, avg-2 Immgen.org, GSE15907 1.837E-45 8.300E-44 6.802E-43 3.735E-42 60 399
45 Lungmap Mouse e16.5 Epithelial SubClass Uncommitted AT Progenitor Top 500 All Mouse Lung E16.5 Epithelial Uncommitted AT Progenitor top 500 Lungmap Mouse Single Cell (Lungmap.net) 1.837E-45 8.300E-44 6.802E-43 3.735E-42 60 399
46 GSM791110 500 Stem Cells, SC.MPP34F.BM, Lineage- cKit+ Sca-1+ flk2+ CD34+, Bone marrow, avg-2 Immgen.org, GSE15907 4.009E-44 1.772E-42 1.452E-41 8.149E-41 59 401
47 GSM476675 500 gamma delta T cells, Tgd.Th, TCRd+ CD3e+, Thymus, avg-3 Immgen.org, GSE15907 5.621E-44 2.431E-42 1.992E-41 1.143E-40 56 349
48 gudmap kidney e10.5 UretericTip HoxB7 k4 1000 kidney e10.5 UretericTip HoxB7 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 8.242E-43 3.491E-41 2.861E-40 1.676E-39 55 348
49 Lungmap Mouse e14.5 Epithelial (GSE52583) Top 500 All Mouse Lung E14.5 Epithelial top 500 Lungmap Mouse Single Cell (Lungmap.net) 1.491E-42 6.188E-41 5.071E-40 3.032E-39 60 446
50 GSM605773 500 alpha beta T cells, T.8.TI.B16, 4- 8+ TCR+ 45+, B16 Melanoma Tumor, avg-2 Immgen.org, GSE15907 4.690E-42 1.907E-40 1.563E-39 9.534E-39 55 359
Show 45 more annotations

15: Computational [Display Chart] 442 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 54 Genes in module 54 MSigDb: C4 - CM: Cancer Modules 1.145E-62 5.062E-60 3.376E-59 5.062E-60 69 245
2 GNF2 SMC4L1 Neighborhood of SMC4L1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.082E-47 1.123E-44 7.491E-44 2.246E-44 39 76
3 module 158 Genes in module 158 MSigDb: C4 - CM: Cancer Modules 2.239E-45 3.299E-43 2.201E-42 9.898E-43 31 41
4 module 125 Genes in module 125 MSigDb: C4 - CM: Cancer Modules 8.410E-45 9.293E-43 6.198E-42 3.717E-42 31 42
5 GNF2 PCNA Neighborhood of PCNA MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.400E-44 3.006E-42 2.005E-41 1.503E-41 35 62
6 GNF2 RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.424E-42 2.522E-40 1.682E-39 1.513E-39 33 57
7 GNF2 FEN1 Neighborhood of FEN1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.896E-39 1.197E-37 7.985E-37 8.380E-37 30 49
8 module 198 Genes in module 198 MSigDb: C4 - CM: Cancer Modules 5.602E-39 3.095E-37 2.064E-36 2.476E-36 55 292
9 GNF2 RRM1 Neighborhood of RRM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.562E-38 7.669E-37 5.115E-36 6.902E-36 35 82
10 module 252 Genes in module 252 MSigDb: C4 - CM: Cancer Modules 1.416E-37 6.259E-36 4.175E-35 6.259E-35 49 227
11 GNF2 MCM5 Neighborhood of MCM5 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.928E-36 7.748E-35 5.168E-34 8.523E-34 29 52
12 module 98 Genes in module 98 MSigDb: C4 - CM: Cancer Modules 1.151E-33 4.239E-32 2.828E-31 5.087E-31 56 381
13 GNF2 CCNA2 Neighborhood of CCNA2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.132E-30 1.405E-28 9.370E-28 1.826E-27 27 62
14 GNF2 MCM4 Neighborhood of MCM4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 7.156E-30 2.259E-28 1.507E-27 3.163E-27 25 50
15 GNF2 CENPF Neighborhood of CENPF MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.232E-26 3.404E-25 2.271E-24 5.447E-24 24 56
16 GNF2 CDC2 Neighborhood of CDC2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.232E-26 3.404E-25 2.271E-24 5.447E-24 24 56
17 GNF2 CKS2 Neighborhood of CKS2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.247E-26 1.104E-24 7.365E-24 1.877E-23 22 45
18 module 53 Genes in module 53 MSigDb: C4 - CM: Cancer Modules 3.283E-23 8.061E-22 5.376E-21 1.451E-20 46 391
19 module 244 Genes in module 244 MSigDb: C4 - CM: Cancer Modules 1.741E-21 4.049E-20 2.701E-19 7.693E-19 32 183
20 GNF2 MSH2 Neighborhood of MSH2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.832E-21 4.049E-20 2.701E-19 8.099E-19 16 26
21 MORF RRM1 Neighborhood of RRM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 9.258E-21 1.949E-19 1.300E-18 4.092E-18 24 91
22 module 403 Genes in module 403 MSigDb: C4 - CM: Cancer Modules 9.180E-20 1.844E-18 1.230E-17 4.058E-17 18 44
23 GNF2 BUB1B Neighborhood of BUB1B MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.427E-19 4.664E-18 3.111E-17 1.073E-16 18 46
24 GNF2 TTK Neighborhood of TTK MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.603E-19 1.216E-17 8.111E-17 2.919E-16 16 34
25 GNF2 HMMR Neighborhood of HMMR MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.034E-18 3.597E-17 2.399E-16 8.991E-16 17 43
26 MORF RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.372E-18 4.033E-17 2.690E-16 1.049E-15 26 139
27 GNF2 CCNB2 Neighborhood of CCNB2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.920E-18 8.054E-17 5.372E-16 2.175E-15 18 53
28 GNF2 RFC3 Neighborhood of RFC3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.210E-18 9.802E-17 6.538E-16 2.745E-15 16 38
29 GNF2 RRM2 Neighborhood of RRM2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 8.479E-17 1.292E-15 8.620E-15 3.748E-14 15 36
30 module 57 Genes in module 57 MSigDb: C4 - CM: Cancer Modules 1.877E-16 2.765E-15 1.844E-14 8.295E-14 17 54
31 MORF DNMT1 Neighborhood of DNMT1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.891E-15 2.696E-14 1.798E-13 8.359E-13 21 107
32 MORF BUB3 Neighborhood of BUB3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.357E-15 7.399E-14 4.935E-13 2.368E-12 30 260
33 MORF ESPL1 Neighborhood of ESPL1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.569E-14 2.102E-13 1.402E-12 6.936E-12 16 58
34 module 8 Genes in module 8 MSigDb: C4 - CM: Cancer Modules 3.157E-14 4.104E-13 2.737E-12 1.395E-11 36 406
35 module 18 Genes in module 18 MSigDb: C4 - CM: Cancer Modules 5.226E-14 6.600E-13 4.402E-12 2.310E-11 37 436
36 GNF2 SMC2L1 Neighborhood of SMC2L1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.070E-13 2.542E-12 1.695E-11 9.151E-11 12 30
37 GNF2 HAT1 Neighborhood of HAT1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.244E-13 2.680E-12 1.788E-11 9.916E-11 14 47
38 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 4.297E-13 4.998E-12 3.334E-11 1.899E-10 34 395
39 module 16 Genes in module 16 MSigDb: C4 - CM: Cancer Modules 5.411E-13 6.133E-12 4.090E-11 2.392E-10 38 495
40 module 126 Genes in module 126 MSigDb: C4 - CM: Cancer Modules 6.572E-13 7.262E-12 4.844E-11 2.905E-10 23 175
41 GNF2 CDC20 Neighborhood of CDC20 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.063E-12 1.146E-11 7.646E-11 4.700E-10 14 52
42 GNF2 H2AFX Neighborhood of H2AFX MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.745E-12 2.889E-11 1.927E-10 1.213E-9 11 28
43 module 17 Genes in module 17 MSigDb: C4 - CM: Cancer Modules 3.150E-12 3.238E-11 2.160E-10 1.393E-9 31 353
44 GNF2 CENPE Neighborhood of CENPE MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.919E-12 3.937E-11 2.626E-10 1.732E-9 12 37
45 MORF PRKDC Neighborhood of PRKDC MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.774E-12 4.689E-11 3.127E-10 2.110E-9 22 174
46 MORF SMC1L1 Neighborhood of SMC1L1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.484E-12 6.230E-11 4.155E-10 2.866E-9 13 48
47 MORF FEN1 Neighborhood of FEN1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 7.064E-12 6.644E-11 4.431E-10 3.122E-9 14 59
48 GNF2 PA2G4 Neighborhood of PA2G4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.152E-11 1.061E-10 7.077E-10 5.094E-9 15 73
49 MORF PCNA Neighborhood of PCNA MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.420E-11 1.281E-10 8.543E-10 6.277E-9 15 74
50 GNF2 ANP32B Neighborhood of ANP32B MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.537E-11 1.359E-10 9.064E-10 6.795E-9 11 32
Show 45 more annotations

16: MicroRNA [Display Chart] 1171 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-24:miRTarbase hsa-miR-24:miRTarbase miRTarbase 8.968E-7 1.050E-3 8.026E-3 1.050E-3 7 38
2 hsa-miR-192:miRTarbase hsa-miR-192:miRTarbase miRTarbase 2.275E-5 1.332E-2
1.018E-1
 2.664E-2 5 25

17: Drug [Display Chart] 20115 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C488369 dasatinib CTD 8.509E-99 1.368E-94 1.434E-93 1.712E-94 102 472
2 D000069439 Dasatinib CTD 1.360E-98 1.368E-94 1.434E-93 2.735E-94 102 474
3 D008154 Lucanthone CTD 4.425E-52 2.967E-48 3.111E-47 8.901E-48 52 212
4 C500026 palbociclib CTD 4.743E-51 2.385E-47 2.501E-46 9.542E-47 48 172
5 CID000004156 methyl methanesulfonate Stitch 3.430E-49 1.380E-45 1.447E-44 6.900E-45 60 364
6 CID000002210 NSC351140 Stitch 2.785E-47 9.336E-44 9.790E-43 5.601E-43 52 258
7 CID000003657 hydroxyurea Stitch 1.073E-46 3.083E-43 3.233E-42 2.158E-42 62 438
8 C408982 CPG-oligonucleotide CTD 5.593E-45 1.406E-41 1.475E-40 1.125E-40 45 184
9 C059765 amphotericin B, deoxycholate drug combination CTD 4.590E-44 1.026E-40 1.076E-39 9.234E-40 56 365
10 C496197 trans-10,cis-12-conjugated linoleic acid CTD 5.782E-43 1.163E-39 1.220E-38 1.163E-38 43 176
11 D002509 Cephaloridine CTD 4.007E-37 7.328E-34 7.684E-33 8.060E-33 55 464
12 C058305 phenethyl isothiocyanate CTD 2.282E-36 3.824E-33 4.011E-32 4.589E-32 51 393
13 CID000005192 sebacate Stitch 1.295E-28 2.003E-25 2.101E-24 2.604E-24 33 181
14 CID000002538 NSC302991 Stitch 2.458E-27 3.315E-24 3.476E-23 4.944E-23 41 353
15 C547185 riccardin D CTD 2.472E-27 3.315E-24 3.476E-23 4.972E-23 24 76
16 CID000001151 AC1Q6S3S Stitch 4.298E-24 5.404E-21 5.666E-20 8.646E-20 27 142
17 6902 DN 0297417-0002B [362658-29-5]; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 9.327E-24 1.104E-20 1.157E-19 1.876E-19 30 196
18 CID000005746 mitomycin C Stitch 2.623E-23 2.931E-20 3.074E-19 5.276E-19 32 241
19 CID000006623 bisphenol A Stitch 3.216E-23 3.404E-20 3.570E-19 6.469E-19 31 223
20 CID000001174 uracil Stitch 6.760E-23 6.799E-20 7.130E-19 1.360E-18 33 269
21 CID000000597 cytosine Stitch 1.307E-22 1.252E-19 1.313E-18 2.630E-18 40 441
22 C014026 hexamethylene bisacetamide CTD 8.698E-21 7.952E-18 8.339E-17 1.750E-16 18 57
23 1998 DN Niclosamide [50-65-7]; Down 200; 12.2uM; HL60; HG-U133A Broad Institute CMAP 9.894E-21 8.653E-18 9.074E-17 1.990E-16 27 188
24 D048789 Phytoestrogens CTD 9.323E-20 7.814E-17 8.194E-16 1.875E-15 18 64
25 CID002723601 6-thioguanine Stitch 1.101E-18 8.857E-16 9.288E-15 2.214E-14 22 130
26 CID000072271 UCN-01 Stitch 3.243E-18 2.509E-15 2.631E-14 6.522E-14 23 154
27 D014747 Vinblastine CTD 4.786E-18 3.566E-15 3.739E-14 9.627E-14 28 260
28 CID000000625 AC1Q6S3R Stitch 2.047E-17 1.471E-14 1.542E-13 4.118E-13 17 71
29 D007840 Latex CTD 3.146E-17 2.182E-14 2.288E-13 6.328E-13 24 190
30 CID000000621 NSC82625 Stitch 6.615E-17 4.436E-14 4.651E-13 1.331E-12 21 138
31 C006551 2-amino-2-methyl-1-propanol CTD 9.184E-17 5.959E-14 6.249E-13 1.847E-12 30 342
32 D016685 Mitomycin CTD 2.104E-16 1.323E-13 1.387E-12 4.232E-12 32 408
33 CID000001139 NSC46713 Stitch 2.584E-16 1.575E-13 1.652E-12 5.197E-12 24 208
34 CID000065577 Topo Stitch 5.747E-16 3.400E-13 3.565E-12 1.156E-11 21 153
35 CID000345751 NSC403510 Stitch 6.346E-16 3.647E-13 3.824E-12 1.276E-11 18 101
36 CID000000646 AC1Q6S3Y Stitch 1.488E-15 8.316E-13 8.720E-12 2.994E-11 17 90
37 CID005282473 Zinostatino Stitch 2.586E-15 1.406E-12 1.474E-11 5.202E-11 16 78
38 C010914 2,4-diaminotoluene CTD 6.754E-15 3.575E-12 3.749E-11 1.359E-10 24 240
39 6895 DN 0297417-0002B [362658-29-5]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 7.584E-15 3.912E-12 4.102E-11 1.526E-10 22 195
40 CID000000593 NSC20261 Stitch 1.423E-14 7.155E-12 7.503E-11 2.862E-10 23 224
41 C056493 imiquimod CTD 1.667E-14 8.177E-12 8.575E-11 3.353E-10 14 59
42 CID000000622 2'-deoxyadenosine 5'-triphosphate Stitch 4.189E-14 2.006E-11 2.104E-10 8.426E-10 17 109
43 6900 DN 0297417-0002B [362658-29-5]; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 5.304E-14 2.481E-11 2.602E-10 1.067E-9 21 191
44 CID000011254 diepoxybutane Stitch 7.758E-14 3.547E-11 3.719E-10 1.561E-9 17 113
45 C063002 2,3-dimethoxy-1,4-naphthoquinone CTD 9.403E-14 4.203E-11 4.408E-10 1.891E-9 19 153
46 2439 DN Menadione [58-27-5]; Down 200; 23.2uM; HL60; HT HG-U133A Broad Institute CMAP 9.836E-14 4.301E-11 4.510E-10 1.978E-9 21 197
47 CID000005955 4NQO Stitch 1.212E-13 5.186E-11 5.438E-10 2.437E-9 17 116
48 D012835 Silver Nitrate CTD 1.619E-13 6.785E-11 7.115E-10 3.257E-9 17 118
49 CID005473385 Thioguanine (usan Stitch 1.708E-13 7.012E-11 7.353E-10 3.436E-9 15 84
50 978 DN pyrvinium pamoate; Down 200; 1.25uM; MCF7; HT HG-U133A EA Broad Institute CMAP 2.413E-13 9.709E-11 1.018E-9 4.854E-9 20 183
Show 45 more annotations

18: Disease [Display Chart] 1799 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C3469521 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) DisGeNET Curated 8.380E-21 1.508E-17 1.217E-16 1.508E-17 30 219
2 umls:C0015625 Fanconi Anemia DisGeNET Curated 2.208E-19 1.986E-16 1.603E-15 3.972E-16 30 245
3 umls:C0004135 Ataxia Telangiectasia DisGeNET Curated 1.079E-13 6.471E-11 5.224E-10 1.941E-10 22 196
4 umls:C0346153 Breast Cancer, Familial DisGeNET Curated 4.072E-12 1.831E-9 1.478E-8 7.326E-9 18 146
5 umls:C0677776 Hereditary Breast and Ovarian Cancer Syndrome DisGeNET Curated 1.399E-10 5.032E-8 4.062E-7 2.516E-7 11 51
6 cv:C1861028 Tracheoesophageal fistula Clinical Variations 3.084E-10 9.248E-8 7.466E-7 5.549E-7 8 21
7 umls:C0265202 Seckel syndrome DisGeNET Curated 5.486E-9 1.410E-6 1.138E-5 9.869E-6 7 19
8 umls:C0027672 Neoplastic Syndromes, Hereditary DisGeNET Curated 9.950E-9 2.237E-6 1.806E-5 1.790E-5 10 58
9 umls:C0023452 Leukemia, Lymphocytic, Acute, L1 DisGeNET Curated 1.171E-8 2.342E-6 1.890E-5 2.108E-5 23 387
10 umls:C1333600 Hereditary Malignant Neoplasm DisGeNET BeFree 1.655E-8 2.915E-6 2.353E-5 2.978E-5 10 61
11 umls:C0035335 Retinoblastoma DisGeNET Curated 1.782E-8 2.915E-6 2.353E-5 3.206E-5 25 463
12 umls:C1336076 Sporadic Breast Carcinoma DisGeNET BeFree 3.113E-8 4.666E-6 3.767E-5 5.600E-5 14 147
13 umls:C0005859 Bloom Syndrome DisGeNET Curated 1.127E-7 1.559E-5 1.259E-4 2.027E-4 8 41
14 cv:C0346153 Familial cancer of breast Clinical Variations 9.625E-7 1.154E-4 9.319E-4 1.732E-3 6 24
15 114480 BREAST CANCER OMIM 9.625E-7 1.154E-4 9.319E-4 1.732E-3 6 24
16 umls:C0679427 myeloblastosis DisGeNET BeFree 1.125E-6 1.264E-4 1.021E-3 2.023E-3 5 14
17 umls:C1868684 EAR, PATELLA, SHORT STATURE SYNDROME DisGeNET Curated 1.478E-6 1.564E-4 1.263E-3 2.659E-3 4 7
18 umls:C0342573 PITUITARY DWARFISM I DisGeNET Curated 1.667E-6 1.666E-4 1.345E-3 2.999E-3 5 15
19 umls:C0016412 Folic Acid Deficiency DisGeNET Curated 2.566E-6 2.430E-4 1.961E-3 4.616E-3 6 28
20 umls:C0025958 Microcephaly DisGeNET Curated 2.823E-6 2.503E-4 2.021E-3 5.079E-3 12 155
21 227650 FANCONI ANEMIA; FA OMIM 2.922E-6 2.503E-4 2.021E-3 5.257E-3 4 8
22 umls:C3711387 Autosomal Recessive Primary Microcephaly DisGeNET BeFree 3.354E-6 2.743E-4 2.214E-3 6.034E-3 5 17
23 umls:C2986665 Early-Stage Breast Carcinoma DisGeNET BeFree 3.914E-6 3.062E-4 2.471E-3 7.042E-3 8 64
24 umls:C0334634 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse DisGeNET Curated 4.133E-6 3.098E-4 2.501E-3 7.435E-3 17 317
25 umls:C1134719 Invasive Ductal Breast Carcinoma DisGeNET Curated 6.465E-6 4.652E-4 3.755E-3 1.163E-2 14 228
26 umls:C0151779 Cutaneous Melanoma DisGeNET Curated 6.740E-6 4.663E-4 3.765E-3 1.212E-2 15 261
27 umls:C0043119 Werner Syndrome DisGeNET Curated 1.062E-5 7.078E-4 5.714E-3 1.911E-2 8 73
28 umls:C3539878 Triple Negative Breast Neoplasms DisGeNET BeFree 1.201E-5 7.468E-4 6.028E-3 2.161E-2 20 456
29 umls:C3697776 Proliferative verrucous oral leukoplakia DisGeNET BeFree 1.204E-5 7.468E-4 6.028E-3 2.166E-2 3 4
30 umls:C0032339 Rothmund-Thomson syndrome DisGeNET Curated 1.698E-5 1.018E-3 8.221E-3 3.055E-2 5 23
31 umls:C0043346 Xeroderma Pigmentosum DisGeNET Curated 2.077E-5 1.205E-3 9.730E-3 3.736E-2 9 104
32 umls:C0023530 Leukopenia DisGeNET Curated 2.635E-5 1.481E-3 1.196E-2 4.741E-2 12 193
33 umls:C0153467 Malignant tumor of peritoneum DisGeNET BeFree 2.818E-5 1.536E-3 1.240E-2
5.070E-2
 4 13
34 umls:C1333991 Hereditary Non-Polyposis Colon Cancer Type 2 DisGeNET Curated 2.977E-5 1.575E-3 1.272E-2
5.356E-2
 3 5
35 umls:C1333990 Hereditary Nonpolyposis Colorectal Cancer DisGeNET Curated 5.668E-5 2.914E-3 2.352E-2
1.020E-1
 9 118
36 umls:C0005695 Bladder Neoplasm DisGeNET Curated 6.295E-5 3.143E-3 2.537E-2
1.132E-1
 15 316
37 umls:C0349566 Squamous cell carcinoma of tongue DisGeNET BeFree 6.465E-5 3.143E-3 2.537E-2
1.163E-1
 9 120
38 umls:C0010606 Adenoid Cystic Carcinoma DisGeNET Curated 8.558E-5 4.051E-3 3.270E-2
1.540E-1
 11 185
39 umls:C1112474 Small cell carcinoma of esophagus DisGeNET BeFree 1.020E-4 4.586E-3 3.702E-2
1.834E-1
 3 7
40 umls:C0392475 Roberts-SC phocomelia syndrome DisGeNET Curated 1.020E-4 4.586E-3 3.702E-2
1.834E-1
 3 7
41 umls:C0346429 Multiple malignancy DisGeNET BeFree 1.086E-4 4.764E-3 3.846E-2
1.953E-1
 11 190
42 umls:C0431350 Primary microcephaly DisGeNET Curated 1.139E-4 4.829E-3 3.898E-2
2.049E-1
 4 18
43 umls:C1336735 Treatment related acute myeloid leukaemia DisGeNET BeFree 1.154E-4 4.829E-3 3.898E-2
2.076E-1
 6 53
44 umls:C0036503 Sebaceous Gland Neoplasms DisGeNET Curated 1.614E-4 6.508E-3
5.253E-2
2.904E-1
 3 8
45 umls:C1559154 Rash and Dermatitis Adverse Event Associated with Chemoradiation DisGeNET BeFree 1.628E-4 6.508E-3
5.253E-2
2.929E-1
 7 80
46 umls:C1334411 Locally Metastatic Malignant Neoplasm DisGeNET BeFree 2.108E-4 7.065E-3
5.703E-2
3.793E-1
 2 2
47 umls:C0424091 Loss of interest DisGeNET BeFree 2.108E-4 7.065E-3
5.703E-2
3.793E-1
 2 2
48 cv:C0677776 BRCA1 and BRCA2 Hereditary Breast and Ovarian Cancer Clinical Variations 2.108E-4 7.065E-3
5.703E-2
3.793E-1
 2 2
49 umls:C0031149 Peritoneal Neoplasms DisGeNET BeFree 2.108E-4 7.065E-3
5.703E-2
3.793E-1
 2 2
50 120435 LYNCH SYNDROME I OMIM 2.108E-4 7.065E-3
5.703E-2
3.793E-1
 2 2
Show 45 more annotations