Toppgene analysis for aggregated_1964_log, IC2, negative side

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1: GO: Molecular Function [Display Chart] 36 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific) 1.063E-3 2.866E-2
1.196E-1
 3.825E-2 1 2
2 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific) 1.593E-3 2.866E-2
1.196E-1
5.736E-2
 1 3
3 GO:0032453 histone demethylase activity (H3-K4 specific) 3.184E-3 2.866E-2
1.196E-1
1.146E-1
 1 6
4 GO:0010997 anaphase-promoting complex binding 3.184E-3 2.866E-2
1.196E-1
1.146E-1
 1 6
5 GO:0008017 microtubule binding 5.454E-3 3.685E-2
1.538E-1
1.963E-1
 2 214
6 GO:0005092 GDP-dissociation inhibitor activity 6.888E-3 3.685E-2
1.538E-1
2.480E-1
 1 13
7 GO:0004303 estradiol 17-beta-dehydrogenase activity 7.416E-3 3.685E-2
1.538E-1
2.670E-1
 1 14
8 GO:0015631 tubulin binding 1.001E-2 3.685E-2
1.538E-1
3.604E-1
 2 293
9 GO:0032452 histone demethylase activity 1.373E-2 3.685E-2
1.538E-1
4.944E-1
 1 26
10 GO:0052634 C-19 gibberellin 2-beta-dioxygenase activity 1.688E-2 3.685E-2
1.538E-1
6.076E-1
 1 32
11 GO:0034792 hypophosphite dioxygenase activity 1.688E-2 3.685E-2
1.538E-1
6.076E-1
 1 32
12 GO:0045543 gibberellin 2-beta-dioxygenase activity 1.688E-2 3.685E-2
1.538E-1
6.076E-1
 1 32
13 GO:0000907 sulfonate dioxygenase activity 1.688E-2 3.685E-2
1.538E-1
6.076E-1
 1 32
14 GO:0018602 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity 1.688E-2 3.685E-2
1.538E-1
6.076E-1
 1 32
15 GO:0052635 C-20 gibberellin 2-beta-dioxygenase activity 1.688E-2 3.685E-2
1.538E-1
6.076E-1
 1 32
16 GO:0043734 DNA-N1-methyladenine dioxygenase activity 1.740E-2 3.685E-2
1.538E-1
6.265E-1
 1 33
17 GO:0001965 G-protein alpha-subunit binding 1.740E-2 3.685E-2
1.538E-1
6.265E-1
 1 33
18 GO:0032451 demethylase activity 1.845E-2 3.690E-2
1.540E-1
6.641E-1
 1 35
19 GO:0019798 procollagen-proline dioxygenase activity 2.054E-2 3.878E-2
1.619E-1
7.393E-1
 1 39
20 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2.158E-2 3.878E-2
1.619E-1
7.769E-1
 1 41
21 GO:0031543 peptidyl-proline dioxygenase activity 2.262E-2 3.878E-2
1.619E-1
8.144E-1
 1 43
22 GO:0016229 steroid dehydrogenase activity 2.418E-2 3.957E-2
1.652E-1
8.706E-1
 1 46
Show 17 more annotations

2: GO: Biological Process [Display Chart] 264 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000281 mitotic cytokinesis 1.591E-4 2.008E-2
1.236E-1
 4.201E-2 2 36
2 GO:0061640 cytoskeleton-dependent cytokinesis 2.494E-4 2.008E-2
1.236E-1
6.585E-2
 2 45
3 GO:2000864 regulation of estradiol secretion 5.323E-4 2.008E-2
1.236E-1
1.405E-1
 1 1
4 GO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific 5.323E-4 2.008E-2
1.236E-1
1.405E-1
 1 1
5 GO:0035937 estrogen secretion 5.323E-4 2.008E-2
1.236E-1
1.405E-1
 1 1
6 GO:0035938 estradiol secretion 5.323E-4 2.008E-2
1.236E-1
1.405E-1
 1 1
7 GO:2000861 regulation of estrogen secretion 5.323E-4 2.008E-2
1.236E-1
1.405E-1
 1 1
8 GO:0001578 microtubule bundle formation 7.688E-4 2.440E-2
1.502E-1
2.030E-1
 2 79
9 GO:0006710 androgen catabolic process 1.064E-3 2.440E-2
1.502E-1
2.810E-1
 1 2
10 GO:2000312 regulation of kainate selective glutamate receptor activity 1.064E-3 2.440E-2
1.502E-1
2.810E-1
 1 2
11 GO:0070194 synaptonemal complex disassembly 1.064E-3 2.440E-2
1.502E-1
2.810E-1
 1 2
12 GO:0007052 mitotic spindle organization 1.109E-3 2.440E-2
1.502E-1
2.928E-1
 2 95
13 GO:0000226 microtubule cytoskeleton organization 1.588E-3 3.010E-2
1.853E-1
4.193E-1
 3 465
14 GO:0051661 maintenance of centrosome location 1.596E-3 3.010E-2
1.853E-1
4.214E-1
 1 3
15 GO:0016321 female meiosis chromosome segregation 2.128E-3 3.745E-2
2.305E-1
5.617E-1
 1 4
16 GO:0000910 cytokinesis 2.592E-3 3.904E-2
2.403E-1
6.842E-1
 2 146
17 GO:0061038 uterus morphogenesis 2.659E-3 3.904E-2
2.403E-1
7.020E-1
 1 5
18 GO:0007051 spindle organization 2.662E-3 3.904E-2
2.403E-1
7.027E-1
 2 148
19 GO:0040038 polar body extrusion after meiotic divisions 3.190E-3 4.433E-2
2.728E-1
8.422E-1
 1 6
20 GO:0060763 mammary duct terminal end bud growth 3.721E-3 4.678E-2
2.879E-1
9.824E-1
 1 7
21 GO:0034720 histone H3-K4 demethylation 3.721E-3 4.678E-2
2.879E-1
9.824E-1
 1 7
22 GO:0033601 positive regulation of mammary gland epithelial cell proliferation 4.252E-3 4.855E-2
2.989E-1
1.000E0
 1 8
23 GO:0033206 meiotic cytokinesis 4.252E-3 4.855E-2
2.989E-1
1.000E0
 1 8
24 GO:0000086 G2/M transition of mitotic cell cycle 4.659E-3 4.855E-2
2.989E-1
1.000E0
 2 197
25 GO:0051657 maintenance of organelle location 4.782E-3 4.855E-2
2.989E-1
1.000E0
 1 9
26 GO:0042447 hormone catabolic process 4.782E-3 4.855E-2
2.989E-1
1.000E0
 1 9
27 GO:0044839 cell cycle G2/M phase transition 5.082E-3 4.969E-2
3.059E-1
1.000E0
 2 206
Show 22 more annotations

3: GO: Cellular Component [Display Chart] 40 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005819 spindle 4.532E-4 1.063E-2 4.550E-2 1.813E-2 3 308
2 GO:0005811 lipid particle 5.317E-4 1.063E-2 4.550E-2 2.127E-2 2 67
3 GO:0000922 spindle pole 2.072E-3 1.758E-2
7.520E-2
8.290E-2
 2 133
4 GO:0000942 condensed nuclear chromosome outer kinetochore 2.085E-3 1.758E-2
7.520E-2
8.340E-2
 1 4
5 GO:0030496 midbody 2.197E-3 1.758E-2
7.520E-2
8.788E-2
 2 137
6 GO:0000778 condensed nuclear chromosome kinetochore 5.205E-3 3.470E-2
1.485E-1
2.082E-1
 1 10
7 GO:0000940 condensed chromosome outer kinetochore 6.762E-3 3.640E-2
1.557E-1
2.705E-1
 1 13
8 GO:0097431 mitotic spindle pole 7.280E-3 3.640E-2
1.557E-1
2.912E-1
 1 14
9 GO:0000780 condensed nuclear chromosome, centromeric region 1.090E-2 4.845E-2
2.073E-1
4.361E-1
 1 21
Show 4 more annotations

4: Human Phenotype [Display Chart] 13 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0008625 Severe sensorineural hearing impairment 6.803E-4 5.306E-3 1.687E-2 8.844E-3 1 3
2 HP:0002281 Gray matter heterotopias 9.070E-4 5.306E-3 1.687E-2 1.179E-2 1 4
3 HP:0002700 Large foramen magnum 1.361E-3 5.306E-3 1.687E-2 1.769E-2 1 6
4 HP:0100702 Arachnoid cyst 2.041E-3 5.306E-3 1.687E-2 2.653E-2 1 9
5 HP:0006989 Dysplastic corpus callosum 2.041E-3 5.306E-3 1.687E-2 2.653E-2 1 9
6 HP:0007033 Cerebellar dysplasia 2.721E-3 5.896E-3 1.875E-2 3.537E-2 1 12
7 HP:0001338 Partial agenesis of the corpus callosum 3.628E-3 6.738E-3 2.143E-2 4.717E-2 1 16
8 HP:0002126 Polymicrogyria 1.497E-2 2.432E-2
7.734E-2
1.946E-1
 1 66
9 HP:0001321 Cerebellar hypoplasia 2.336E-2 3.066E-2
9.750E-2
3.036E-1
 1 103
10 HP:0001256 Intellectual disability, mild {has synonym type="layperson"} 2.358E-2 3.066E-2
9.750E-2
3.066E-1
 1 104
11 HP:0002119 Ventriculomegaly 2.993E-2 3.537E-2
1.125E-1
3.891E-1
 1 132
12 HP:0000238 Hydrocephalus 3.333E-2 3.605E-2
1.147E-1
4.333E-1
 1 147
13 HP:0002079 Hypoplasia of the corpus callosum 3.605E-2 3.605E-2
1.147E-1
4.687E-1
 1 159
Show 8 more annotations

5: Mouse Phenotype [Display Chart] 99 annotations before applied cutoff / 9299 genes in category

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6: Domain [Display Chart] 109 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR027326 KIF20A InterPro 5.338E-4 1.761E-2
9.288E-2
5.818E-2
 1 1
2 IPR030596 KLHL24 InterPro 5.338E-4 1.761E-2
9.288E-2
5.818E-2
 1 1
3 IPR033702 PLK1 cat InterPro 5.338E-4 1.761E-2
9.288E-2
5.818E-2
 1 1
4 IPR033695 POLO box 2 InterPro 1.601E-3 1.761E-2
9.288E-2
1.745E-1
 1 3
5 IPR033701 POLO box 1 InterPro 2.134E-3 1.761E-2
9.288E-2
2.326E-1
 1 4
6 PS50078 POLO BOX PROSITE 2.134E-3 1.761E-2
9.288E-2
2.326E-1
 1 4
7 IPR013637 Lys sp deMease-like dom InterPro 2.134E-3 1.761E-2
9.288E-2
2.326E-1
 1 4
8 3.30.1120.30 - Gene3D 2.134E-3 1.761E-2
9.288E-2
2.326E-1
 1 4
9 PF00659 POLO box Pfam 2.134E-3 1.761E-2
9.288E-2
2.326E-1
 1 4
10 PF08429 PLU-1 Pfam 2.134E-3 1.761E-2
9.288E-2
2.326E-1
 1 4
11 IPR019734 TPR repeat InterPro 2.168E-3 1.761E-2
9.288E-2
2.364E-1
 2 133
12 IPR004279 Perilipin InterPro 2.666E-3 1.761E-2
9.288E-2
2.906E-1
 1 5
13 PF03036 Perilipin Pfam 2.666E-3 1.761E-2
9.288E-2
2.906E-1
 1 5
14 PF02928 zf-C5HC2 Pfam 2.666E-3 1.761E-2
9.288E-2
2.906E-1
 1 5
15 IPR000959 POLO box dom InterPro 2.666E-3 1.761E-2
9.288E-2
2.906E-1
 1 5
16 IPR004198 Znf C5HC2 InterPro 2.666E-3 1.761E-2
9.288E-2
2.906E-1
 1 5
17 IPR013026 TPR-contain dom InterPro 2.747E-3 1.761E-2
9.288E-2
2.995E-1
 2 150
18 PS50293 TPR REGION PROSITE 3.312E-3 1.768E-2
9.324E-2
3.610E-1
 2 165
19 PS50005 TPR PROSITE 3.312E-3 1.768E-2
9.324E-2
3.610E-1
 2 165
20 IPR003109 GoLoco motif InterPro 3.731E-3 1.768E-2
9.324E-2
4.067E-1
 1 7
21 SM00390 GoLoco SMART 3.731E-3 1.768E-2
9.324E-2
4.067E-1
 1 7
22 PF02188 GoLoco Pfam 3.731E-3 1.768E-2
9.324E-2
4.067E-1
 1 7
23 PS50877 GOLOCO PROSITE 3.731E-3 1.768E-2
9.324E-2
4.067E-1
 1 7
24 IPR003349 JmjN InterPro 5.326E-3 2.073E-2
1.093E-1
5.805E-1
 1 10
25 PS51183 JMJN PROSITE 5.326E-3 2.073E-2
1.093E-1
5.805E-1
 1 10
26 SM00545 JmjN SMART 5.326E-3 2.073E-2
1.093E-1
5.805E-1
 1 10
27 PF13176 TPR 7 Pfam 5.326E-3 2.073E-2
1.093E-1
5.805E-1
 1 10
28 PF02375 JmjN Pfam 5.326E-3 2.073E-2
1.093E-1
5.805E-1
 1 10
29 IPR006911 ARM-rpt dom InterPro 5.857E-3 2.128E-2
1.122E-1
6.384E-1
 1 11
30 PF04826 Arm 2 Pfam 5.857E-3 2.128E-2
1.122E-1
6.384E-1
 1 11
31 PS51011 ARID PROSITE 7.980E-3 2.416E-2
1.274E-1
8.698E-1
 1 15
32 SM00501 BRIGHT SMART 7.980E-3 2.416E-2
1.274E-1
8.698E-1
 1 15
33 PF01388 ARID Pfam 7.980E-3 2.416E-2
1.274E-1
8.698E-1
 1 15
34 IPR001606 ARID dom InterPro 7.980E-3 2.416E-2
1.274E-1
8.698E-1
 1 15
35 IPR032458 Histone H2A CS InterPro 7.980E-3 2.416E-2
1.274E-1
8.698E-1
 1 15
36 1.10.150.60 - Gene3D 7.980E-3 2.416E-2
1.274E-1
8.698E-1
 1 15
37 IPR011989 ARM-like InterPro 8.689E-3 2.526E-2
1.332E-1
9.471E-1
 2 271
38 PF16211 Histone H2A C Pfam 9.039E-3 2.526E-2
1.332E-1
9.853E-1
 1 17
39 IPR032454 Histone H2A C InterPro 9.039E-3 2.526E-2
1.332E-1
9.853E-1
 1 17
40 PS00046 HISTONE H2A PROSITE 1.116E-2 3.040E-2
1.603E-1
1.000E0
 1 21
41 IPR002119 Histone H2A InterPro 1.221E-2 3.169E-2
1.671E-1
1.000E0
 1 23
42 SM00414 H2A SMART 1.221E-2 3.169E-2
1.671E-1
1.000E0
 1 23
43 PF02373 JmjC Pfam 1.274E-2 3.229E-2
1.703E-1
1.000E0
 1 24
44 IPR011072 HR1 rho-bd InterPro 1.327E-2 3.287E-2
1.733E-1
1.000E0
 1 25
45 2.130.10.80 - Gene3D 1.432E-2 3.469E-2
1.829E-1
1.000E0
 1 27
46 PS51184 JMJC PROSITE 1.695E-2 3.932E-2
2.073E-1
1.000E0
 1 32
47 IPR003347 JmjC dom InterPro 1.695E-2 3.932E-2
2.073E-1
1.000E0
 1 32
48 SM00558 JmjC SMART 1.748E-2 3.969E-2
2.093E-1
1.000E0
 1 33
49 IPR015916 Gal Oxidase b-propeller InterPro 1.800E-2 4.005E-2
2.112E-1
1.000E0
 1 34
50 PS50176 ARM REPEAT PROSITE 2.115E-2 4.223E-2
2.227E-1
1.000E0
 1 40
Show 45 more annotations

7: Pathway [Display Chart] 72 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 105819 Mitotic Telophase/Cytokinesis BioSystems: REACTOME 2.285E-5 1.645E-3 7.995E-3 1.645E-3 2 14
2 138007 PLK1 signaling events BioSystems: Pathway Interaction Database 2.358E-4 8.018E-3 3.898E-2 1.697E-2 2 44
3 105811 Loss of Nlp from mitotic centrosomes BioSystems: REACTOME 5.000E-4 8.018E-3 3.898E-2 3.600E-2 2 64
4 105810 Loss of proteins required for interphase microtubule organization from the centrosome BioSystems: REACTOME 5.000E-4 8.018E-3 3.898E-2 3.600E-2 2 64
5 105808 Recruitment of mitotic centrosome proteins and complexes BioSystems: REACTOME 6.682E-4 8.018E-3 3.898E-2 4.811E-2 2 74
6 105807 Centrosome maturation BioSystems: REACTOME 6.682E-4 8.018E-3 3.898E-2 4.811E-2 2 74
7 771569 Regulation of PLK1 Activity at G2/M Transition BioSystems: REACTOME 8.400E-4 8.640E-3 4.200E-2
6.048E-2
 2 83
8 105765 Cell Cycle, Mitotic BioSystems: REACTOME 1.008E-3 8.792E-3 4.274E-2
7.261E-2
 3 416
9 105817 Mitotic Metaphase/Anaphase Transition BioSystems: REACTOME 1.099E-3 8.792E-3 4.274E-2
7.913E-2
 1 2
10 105801 G2/M Transition BioSystems: REACTOME 1.689E-3 1.143E-2
5.557E-2
1.216E-1
 2 118
11 160942 Mitotic G2-G2/M phases BioSystems: REACTOME 1.747E-3 1.143E-2
5.557E-2
1.258E-1
 2 120
12 138077 Polo-like kinase signaling events in the cell cycle BioSystems: Pathway Interaction Database 2.197E-3 1.318E-2
6.408E-2
1.582E-1
 1 4
13 545303 estradiol biosynthesis I BioSystems: BIOCYC 2.746E-3 1.521E-2
7.392E-2
1.977E-1
 1 5
14 105827 Phosphorylation of Emi1 BioSystems: REACTOME 3.294E-3 1.694E-2
8.235E-2
2.372E-1
 1 6
15 771571 Activation of NIMA Kinases NEK9, NEK6, NEK7 BioSystems: REACTOME 3.842E-3 1.844E-2
8.965E-2
2.766E-1
 1 7
16 105812 M Phase BioSystems: REACTOME 6.377E-3 2.869E-2
1.395E-1
4.591E-1
 2 232
17 907943 superpathway of steroid hormone biosynthesis BioSystems: BIOCYC 7.126E-3 3.018E-2
1.467E-1
5.131E-1
 1 13
18 105814 Golgi Cisternae Pericentriolar Stack Reorganization BioSystems: REACTOME 7.672E-3 3.069E-2
1.492E-1
5.524E-1
 1 14
19 105806 Polo-like kinase mediated events BioSystems: REACTOME 9.310E-3 3.528E-2
1.715E-1
6.703E-1
 1 17
20 105830 Phosphorylation of the APC/C BioSystems: REACTOME 1.095E-2 3.940E-2
1.915E-1
7.881E-1
 1 20
21 105802 Cyclin A/B1 associated events during G2/M transition BioSystems: REACTOME 1.203E-2 4.126E-2
2.006E-1
8.665E-1
 1 22
22 M8560 Cell Cycle: G2/M Checkpoint MSigDB C2 BIOCARTA (v5.1) 1.312E-2 4.295E-2
2.088E-1
9.448E-1
 1 24
23 187197 Kinesins BioSystems: REACTOME 1.421E-2 4.448E-2
2.162E-1
1.000E0
 1 26
Show 18 more annotations

8: Pubmed [Display Chart] 1183 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12939256 Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. Pubmed 3.347E-8 1.980E-5 1.515E-4 3.960E-5 2 2
2 12939256:gr Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. GeneRIF 3.347E-8 1.980E-5 1.515E-4 3.960E-5 2 2
3 14741744 Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Pubmed 4.545E-6 5.619E-4 4.301E-3 5.377E-3 2 17
4 11076968 The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion. Pubmed 5.126E-5 5.619E-4 4.301E-3
6.065E-2
 2 56
5 16462731 The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation. Pubmed 5.312E-5 5.619E-4 4.301E-3
6.284E-2
 2 57
6 12852856 Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. Pubmed 5.501E-5 5.619E-4 4.301E-3
6.508E-2
 2 58
7 7790358 Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function. Pubmed 6.089E-5 5.619E-4 4.301E-3
7.203E-2
 2 61
8 12221128 Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex. Pubmed 7.133E-5 5.619E-4 4.301E-3
8.438E-2
 2 66
9 20508983:gr Centrosome-related genes, genetic variation, and risk of breast cancer. GeneRIF 1.707E-4 5.619E-4 4.301E-3
2.019E-1
 2 102
10 20508983 Centrosome-related genes, genetic variation, and risk of breast cancer. Pubmed 1.707E-4 5.619E-4 4.301E-3
2.019E-1
 2 102
11 12364337 Nuclear translocation of plk1 mediated by its bipartite nuclear localization signal. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
12 17671160:gr Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
13 18557900 Roles of the interactions between Env and Gag proteins in the HIV-1 replication cycle. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
14 22390279 Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
15 20470222:gr Polo-like kinase 1 is essential to DNA damage recovery. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
16 15350223:gr Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
17 19452252 Absence of tumor-specific over-expression of Polo-like kinase 1 (Plk1) in major non-Hodgkin lymphoma and relatively low expression of Plk1 in nasal NK/T cell lymphoma. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
18 20581060:gr Polo-like kinase 1 as predictive marker and therapeutic target for radiotherapy in rectal cancer. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
19 24413556 Polo-like kinase-1 triggers histone phosphorylation by Haspin in mitosis. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
20 12364337:gr Nuclear translocation of plk1 mediated by its bipartite nuclear localization signal. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
21 17003132 Tail-interacting protein TIP47 is a connector between Gag and Env and is required for Env incorporation into HIV-1 virions. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
22 22753241 Proliferation state and polo-like kinase1 dependence of tumorigenic colon cancer cells. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
23 20478252:gr A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
24 19572149 Overexpression of Plk1 promotes malignant progress in human esophageal squamous cell carcinoma. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
25 18298087:gr Plk1 activation by Ste20-like kinase (Slk) phosphorylation and polo-box phosphopeptide binding assayed with the substrate translationally controlled tumor protein (TCTP). GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
26 18391401:gr Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
27 21271384 [Influence of silencing Polo-like kinase 1 on migration and invasion of colorectal cancer cells]. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
28 22281053 Direct regulation of tRNA and 5S rRNA gene transcription by Polo-like kinase 1. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
29 19597481:gr Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
30 17434144 siRNA targeting PLK-1 induces apoptosis of synoviocytes in rheumatoid arthritis. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
31 21348867 A truncating mutation in GPSM2 is associated with recessive non-syndromic hearing loss. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
32 19572149:gr Overexpression of Plk1 promotes malignant progress in human esophageal squamous cell carcinoma. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
33 22887948 Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
34 15458642 Roles of polo-like kinase 1 in the assembly of functional mitotic spindles. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
35 19554017:gr Targeted depletion of Polo-like kinase (Plk) 1 through lentiviral shRNA or a small-molecule inhibitor causes mitotic catastrophe and induction of apoptosis in human melanoma cells. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
36 19451273 TIP47 functions in the biogenesis of lipid droplets. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
37 12631276:gr Lipid droplet and milk lipid globule membrane associated placental protein 17b (PP17b) is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
38 11832491:gr Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
39 23753023 Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
40 22669717 JARID1B protein expression and prognostic implications in uveal melanoma. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
41 19775446 The expression of PLK-1 in cervical carcinoma: a possible target for enhancing chemosensitivity. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
42 15210710:gr Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
43 18547964:gr Polo-like kinase 1 as a new target for non-Hodgkin's lymphoma treatment. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
44 17363312 PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
45 21610149:gr PLK1 Is transcriptionally activated by NF-¿B during cell detachment and enhances anoikis resistance through inhibiting �-catenin degradation in esophageal squamous cell carcinoma. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
46 19004025:gr Overexpression of PLK1 is associated with poor survival by inhibiting apoptosis via enhancement of survivin level in esophageal squamous cell carcinoma. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
47 23046929:gr [Effect of Plk1 330/597 serine phosphorylated mutant on cytokinesis during mitosis]. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
48 26513691 Selective blockade of cancer cell proliferation and anchorage-independent growth by Plk1 activity-dependent suicidal inhibition of its polo-box domain. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
49 22000864 Clinicopathological significance of Polo-like kinase 1 (PLK1) expression in human malignant glioma. Pubmed 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
50 11854496:gr Functional studies on the role of the C-terminal domain of mammalian polo-like kinase. GeneRIF 1.929E-4 5.619E-4 4.301E-3
2.281E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 530 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:FAM214B FAM214B interactions 1.806E-5 5.740E-3 3.932E-2 9.570E-3 2 11
2 int:CDC14A CDC14A interactions 2.166E-5 5.740E-3 3.932E-2 1.148E-2 2 12
3 int:PKMYT1 PKMYT1 interactions 3.933E-5 6.948E-3 4.760E-2 2.085E-2 2 16
4 int:STK25 STK25 interactions 4.296E-4 4.093E-2
2.804E-1
2.277E-1
 2 52
5 int:DBNL DBNL interactions 4.463E-4 4.093E-2
2.804E-1
2.365E-1
 2 53
6 int:ZBTB8A ZBTB8A interactions 4.633E-4 4.093E-2
2.804E-1
2.456E-1
 2 54
7 int:SLITRK3 SLITRK3 interactions 1.209E-3 4.429E-2
3.034E-1
6.409E-1
 1 2
8 int:VGLL3 VGLL3 interactions 1.209E-3 4.429E-2
3.034E-1
6.409E-1
 1 2
9 int:PRDM13 PRDM13 interactions 1.209E-3 4.429E-2
3.034E-1
6.409E-1
 1 2
10 int:ONECUT2 ONECUT2 interactions 1.209E-3 4.429E-2
3.034E-1
6.409E-1
 1 2
11 int:AASDH AASDH interactions 1.209E-3 4.429E-2
3.034E-1
6.409E-1
 1 2
12 int:CECR6 CECR6 interactions 1.209E-3 4.429E-2
3.034E-1
6.409E-1
 1 2
13 int:PCNX1 PCNX1 interactions 1.209E-3 4.429E-2
3.034E-1
6.409E-1
 1 2
14 int:COIL COIL interactions 1.339E-3 4.429E-2
3.034E-1
7.095E-1
 2 92
15 int:HSF1 HSF1 interactions 1.610E-3 4.429E-2
3.034E-1
8.535E-1
 2 101
16 int:NUMA1 NUMA1 interactions 1.674E-3 4.429E-2
3.034E-1
8.872E-1
 2 103
17 int:ZNF239 ZNF239 interactions 1.813E-3 4.429E-2
3.034E-1
9.611E-1
 1 3
18 int:FLJ20712 FLJ20712 interactions 1.813E-3 4.429E-2
3.034E-1
9.611E-1
 1 3
19 int:LRP5L LRP5L interactions 1.813E-3 4.429E-2
3.034E-1
9.611E-1
 1 3
20 int:ZNF366 ZNF366 interactions 1.813E-3 4.429E-2
3.034E-1
9.611E-1
 1 3
21 int:PHGDH PHGDH interactions 1.975E-3 4.429E-2
3.034E-1
1.000E0
 2 112
22 int:ZNF555 ZNF555 interactions 2.417E-3 4.429E-2
3.034E-1
1.000E0
 1 4
23 int:HMGB4 HMGB4 interactions 2.417E-3 4.429E-2
3.034E-1
1.000E0
 1 4
24 int:SRPX SRPX interactions 2.417E-3 4.429E-2
3.034E-1
1.000E0
 1 4
25 int:PABPC4L PABPC4L interactions 2.417E-3 4.429E-2
3.034E-1
1.000E0
 1 4
26 int:ZNF607 ZNF607 interactions 2.417E-3 4.429E-2
3.034E-1
1.000E0
 1 4
27 int:ZNF169 ZNF169 interactions 3.021E-3 4.429E-2
3.034E-1
1.000E0
 1 5
28 int:EMP1 EMP1 interactions 3.021E-3 4.429E-2
3.034E-1
1.000E0
 1 5
29 int:ARMCX1 ARMCX1 interactions 3.021E-3 4.429E-2
3.034E-1
1.000E0
 1 5
30 int:BTN1A1 BTN1A1 interactions 3.021E-3 4.429E-2
3.034E-1
1.000E0
 1 5
31 int:C6orf136 C6orf136 interactions 3.021E-3 4.429E-2
3.034E-1
1.000E0
 1 5
32 int:CACNG3 CACNG3 interactions 3.021E-3 4.429E-2
3.034E-1
1.000E0
 1 5
33 int:ECT2 ECT2 interactions 3.600E-3 4.429E-2
3.034E-1
1.000E0
 2 152
34 int:SHOX2 SHOX2 interactions 3.624E-3 4.429E-2
3.034E-1
1.000E0
 1 6
35 int:HSD17B11 HSD17B11 interactions 3.624E-3 4.429E-2
3.034E-1
1.000E0
 1 6
36 int:INSC INSC interactions 3.624E-3 4.429E-2
3.034E-1
1.000E0
 1 6
37 int:CDC20 CDC20 interactions 3.646E-3 4.429E-2
3.034E-1
1.000E0
 2 153
38 int:MYT1 MYT1 interactions 4.227E-3 4.429E-2
3.034E-1
1.000E0
 1 7
39 int:ZNF136 ZNF136 interactions 4.227E-3 4.429E-2
3.034E-1
1.000E0
 1 7
40 int:ZNF578 ZNF578 interactions 4.227E-3 4.429E-2
3.034E-1
1.000E0
 1 7
41 int:SYTL5 SYTL5 interactions 4.227E-3 4.429E-2
3.034E-1
1.000E0
 1 7
42 int:HIST1H2AC HIST1H2AC interactions 4.227E-3 4.429E-2
3.034E-1
1.000E0
 1 7
43 int:KRBA1 KRBA1 interactions 4.227E-3 4.429E-2
3.034E-1
1.000E0
 1 7
44 int:ZNF71 ZNF71 interactions 4.227E-3 4.429E-2
3.034E-1
1.000E0
 1 7
45 int:DNHD1 DNHD1 interactions 4.227E-3 4.429E-2
3.034E-1
1.000E0
 1 7
46 int:UTP11 UTP11 interactions 4.829E-3 4.429E-2
3.034E-1
1.000E0
 1 8
47 int:CACNA1H CACNA1H interactions 4.829E-3 4.429E-2
3.034E-1
1.000E0
 1 8
48 int:ZNF227 ZNF227 interactions 4.829E-3 4.429E-2
3.034E-1
1.000E0
 1 8
49 int:HS6ST2 HS6ST2 interactions 4.829E-3 4.429E-2
3.034E-1
1.000E0
 1 8
50 int:DRICH1 DRICH1 interactions 4.829E-3 4.429E-2
3.034E-1
1.000E0
 1 8
Show 45 more annotations

10: Cytoband [Display Chart] 10 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Xq21.33-q22.2 Xq21.33-q22.2 5.769E-4 5.769E-3 1.690E-2 5.769E-3 1 2
2 3q22.3 3q22.3 7.477E-3 1.941E-2
5.685E-2
7.477E-2
 1 26
3 4q22.1 4q22.1 7.763E-3 1.941E-2
5.685E-2
7.763E-2
 1 27
4 3q27.1 3q27.1 7.763E-3 1.941E-2
5.685E-2
7.763E-2
 1 27
5 16p12.2 16p12.2 1.063E-2 2.125E-2
6.224E-2
1.063E-1
 1 37
6 1p13.3 1p13.3 2.002E-2 3.336E-2
9.771E-2
2.002E-1
 1 70
7 1q32.1 1q32.1 3.241E-2 4.086E-2
1.197E-1
3.241E-1
 1 114
8 5q31 5q31 3.269E-2 4.086E-2
1.197E-1
3.269E-1
 1 115
Show 3 more annotations

11: Transcription Factor Binding Site [Display Chart] 29 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$NFY Q6 01 V$NFY Q6 01 1.867E-4 5.413E-3 2.145E-2 5.413E-3 3 210

12: Gene Family [Display Chart] 12 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 678 Perilipins genenames.org 2.197E-3 2.636E-2
8.181E-2
 2.636E-2 1 5
2 418 AT-rich interaction domain containing genenames.org 6.578E-3 3.947E-2
1.225E-1
7.893E-2
 1 15
3 485 PHD finger proteins|AT-rich interaction domain containing|Lysine demethylases|EMSY complex genenames.org 1.051E-2 4.010E-2
1.245E-1
1.261E-1
 1 24
4 617 Kelch like|BTB domain containing genenames.org 1.832E-2 4.010E-2
1.245E-1
2.199E-1
 1 42
5 409 Armadillo repeat containing|Protein phosphatase 1 regulatory subunits genenames.org 1.876E-2 4.010E-2
1.245E-1
2.251E-1
 1 43
6 622 Kinesins|Pleckstrin homology domain containing genenames.org 2.005E-2 4.010E-2
1.245E-1
2.406E-1
 1 46
Show 1 more annotation

13: Coexpression [Display Chart] 1178 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2078 Genes periodically expressed in synchronized HeLa cells (cervical carcinoma), with peak during the M/G1 phase of cell cycle. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.099E-7 4.023E-4 3.077E-3 4.829E-4 4 148
2 M14127 Genes up-regulated in multiple myeloma (MM) cell lines treated with both decitabine [PubChem=451668] TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.412E-7 4.023E-4 3.077E-3 1.109E-3 5 461
3 GSE46606 UNSTIM VS CD40L IL2 IL5 DAY3 STIMULATED BCELL UP Genes up-regulated in at day 0 B cell wildtype versus CD40L and IL-2 IL-4 IL-5 stimulated at day 3 B cell wildtype. MSigDB C7: Immunologic Signatures (v5.1) 1.312E-6 4.023E-4 3.077E-3 1.546E-3 4 198
4 M6930 Genes up-regulated in B lymphocytes: anti IgM versus PL2-3 (Chromatin IC). MSigDB C7: Immunologic Signatures (v5.1) 1.366E-6 4.023E-4 3.077E-3 1.609E-3 4 200
5 M3335 Genes up-regulated in at least one of three multiple myeloma (MM) cell lines by TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.495E-6 2.002E-3 1.531E-2 1.001E-2 4 317
6 M11537 Fibroblast serum response genes showing periodic expression during the cell cycle; excluded from the core serum response signature. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.521E-5 4.990E-3 3.817E-2 4.148E-2 3 148
7 M11536 Genes down-regulated in DU-145 cells (prostate cancer) in the absence and presence of a dominant negative form of AKT1 [GeneID=207] upon exposure to HGF [GeneID=3082] for 48 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.561E-5 4.990E-3 3.817E-2 4.194E-2 2 20
8 M17859 Genes down-regulated in UB27 cells (osteosarcoma) at any time point after inducing the expression of a mutant form of WT1 [GeneID=7490]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.640E-5 4.990E-3 3.817E-2 4.288E-2 4 459
9 M18058 Genes up-regulated in primary cultures of ovarian surface epithlium cells exposed to progesterone [PubChem=5994] for 5 days. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.813E-5 4.990E-3 3.817E-2 4.491E-2 3 152
10 M2483 Genes with known mitosis function that were down-regulated in MEF cells (embryonic fibroblast) upon knockout of LIN9 [GeneID=286826]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.070E-5 6.351E-3 4.858E-2
8.328E-2
 2 28
11 M5513 Genes up-regulated in comparison of macrophages versus Th2 cells. MSigDB C7: Immunologic Signatures (v5.1) 8.499E-5 6.351E-3 4.858E-2
1.001E-1
 3 199
12 GSE19888 ADENOSINE A3R ACT VS A3R ACT WITH A3R INH PRETREATMENT IN MAST CELL UP Genes up-regulated in HMC-1 (mast leukemia) cells: Cl-IB-MECA [PubChem=3035850] versus incubated with the ALL1 peptide followed by treatment with Cl-IB-MECA [PubChem=3035850]. MSigDB C7: Immunologic Signatures (v5.1) 8.499E-5 6.351E-3 4.858E-2
1.001E-1
 3 199
13 M5484 Genes up-regulated in comparison of dendritic cells (DC) versus Th2 cells. MSigDB C7: Immunologic Signatures (v5.1) 8.626E-5 6.351E-3 4.858E-2
1.016E-1
 3 200
14 GSE41867 NAIVE VS DAY6 LCMV EFFECTOR CD8 TCELL DN Genes down-regulated in CD8 T cells: naïve versus effectors at day 6. MSigDB C7: Immunologic Signatures (v5.1) 8.626E-5 6.351E-3 4.858E-2
1.016E-1
 3 200
15 M5066 Genes up-regulated in comparison of CD4+ [GeneID=920] CD8+ thymocytes versus CD4- [GeneID=920] CD8+ thymocytes. MSigDB C7: Immunologic Signatures (v5.1) 8.626E-5 6.351E-3 4.858E-2
1.016E-1
 3 200
16 GSE33162 UNTREATED VS 4H LPS STIM HDAC3 KO MACROPHAGE UP Genes up-regulated in macrophages with knockout of HDAC3 [GeneID=8841]: untreated versus LPS. MSigDB C7: Immunologic Signatures (v5.1) 8.626E-5 6.351E-3 4.858E-2
1.016E-1
 3 200
17 M1249 Genes up-regulated in B cell lymphoma tumors expressing an activated form of MYC [GeneID=4609]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.605E-4 1.112E-2
8.507E-2
1.891E-1
 2 42
18 M2066 A list of known cell cycle regulated genes that was compiled from the literature by the authors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.762E-4 1.153E-2
8.823E-2
2.076E-1
 2 44
19 M6117 Genes up-regulated in the A673 cells (Ewing sarcoma) after double knockdown of both FLI1 and DAX1 [GeneID=2313;190] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.964E-4 1.838E-2
1.406E-1
3.492E-1
 2 57
20 M1192 Genes up-regulated in MDA-MB-231 cells (breast cancer, mutated TP53 [GeneID=7157]) undergoing mitotic arrest and apoptosis after treatment with 100 nM docetaxel [PubChem=148124]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.738E-4 2.202E-2
1.684E-1
4.403E-1
 2 64
21 M11763 Genes commonly up-regulated in SK-N-BE cells (neuroblastoma) after RNAi knockdown of CCND1 and CDK4 [GeneID=595;1019]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.096E-4 2.246E-2
1.718E-1
4.825E-1
 2 67
22 M2879 Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.194E-4 2.246E-2
1.718E-1
4.941E-1
 3 342
23 M15699 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 0. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.269E-4 2.698E-2
2.064E-1
6.206E-1
 2 76
24 M3737 Genes up-regulated in OV-90 cells (ovarian cancer) exposed to ascites which inhibited invasion. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.130E-4 2.940E-2
2.249E-1
7.221E-1
 2 82
25 M2761 Top 100 probe sets contrubuting to the positive side of the 2nd principal component; associated with adipocytic differentiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.897E-4 2.940E-2
2.249E-1
8.125E-1
 2 87
26 M1735 Cluster P6 of genes with similar expression profiles in peripheral T lymphocytes after FOXP3 [GeneID=50943] loss of function (LOF). MSigDB C2: CGP Curated Gene Sets (v5.1) 7.542E-4 2.940E-2
2.249E-1
8.885E-1
 2 91
27 M2154 Genes down-regulated in MCF7 cells (breast cancer) at 6 h of estradiol [PubChemID=5757] treatment. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.542E-4 2.940E-2
2.249E-1
8.885E-1
 2 91
28 M1157 Genes up-regulated in MEF cells (embryonic fibroblasts) at 16 hr after serum stimulation and knockdown of E2F3 [GeneID=1871] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.563E-4 2.940E-2
2.249E-1
1.000E0
 2 97
29 M10290 Genes up-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.279E-4 2.940E-2
2.249E-1
1.000E0
 2 101
30 M1577 Strongly up-regulated at 16-24 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.279E-4 2.940E-2
2.249E-1
1.000E0
 2 101
31 M7357 Genes up-regulated at early stages of progenitor T lymphocyte maturation compared to the late stages. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.040E-3 2.940E-2
2.249E-1
1.000E0
 2 107
32 M12804 Genes up-regulated in P14 nerves of transgenic mice having hypomorhic (reduced function) allele of EGR2 [GeneID=1959]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.060E-3 2.940E-2
2.249E-1
1.000E0
 2 108
33 M11090 Genes up-regulated in MDA-MB-231 cells (breast cancer) after knockdown of PTHLH [GeneID=5744] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.139E-3 2.940E-2
2.249E-1
1.000E0
 2 112
34 M2590 Genes down-regulated in B lymphocytes at 6 h after exprosure to 10 Gy dose of ionizing radiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.180E-3 2.940E-2
2.249E-1
1.000E0
 2 114
35 M6680 Genes down-regulated in bone marrow-derived macrophages at 180 min of stimulation byLPS: wildtype versus IL6 [GeneID=3469] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.600E-3 2.940E-2
2.249E-1
1.000E0
 2 133
36 M6451 Genes down-regulated in P493-6 cells (B lymphocyte, Burkitt's lymphoma model) upon knockdown of TFRC [GeneID=7037] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.697E-3 2.940E-2
2.249E-1
1.000E0
 2 137
37 M15664 The 'Cervical Cancer Proliferation Cluster' (CCPC): genes whose expression in cervical carcinoma positively correlates with that of the HPV E6 and E7 oncogenes; they are also differentially expressed according to disease outcome. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.771E-3 2.940E-2
2.249E-1
1.000E0
 2 140
38 M6683 Genes down-regulated in bone marrow-derived macrophages at 180 min of stimulation with IL10 [GeneID=3486] and LPS: wildtype versus IL6 [GeneID=3469] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.821E-3 2.940E-2
2.249E-1
1.000E0
 2 142
39 M5408 Genes whose expression decreases with age in normal kidney. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.872E-3 2.940E-2
2.249E-1
1.000E0
 2 144
40 GSE13547 WT VS ZFX KO BCELL ANTI IGM STIM 12H DN Genes down-regulated in B lymphocytes stimulated by anti-IgM for 12h: wildtype versus ZFX [GeneID=7543] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.924E-3 2.940E-2
2.249E-1
1.000E0
 2 146
41 M11837 Genes whose expression decreases with age in normal kidney, excluding those with higher expression in blood. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.002E-3 2.940E-2
2.249E-1
1.000E0
 2 149
42 M3766 Up-regulated genes whose expression correlated with histologic grade of invasive breast cancer tumors: comparison of grade 1 vs grade 3. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.056E-3 2.940E-2
2.249E-1
1.000E0
 2 151
43 M6707 Genes up-regulated in endothelial cells: untreated versus exposed to E. burgdoferi. MSigDB C7: Immunologic Signatures (v5.1) 2.110E-3 2.940E-2
2.249E-1
1.000E0
 2 153
44 M988 Genes up-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.110E-3 2.940E-2
2.249E-1
1.000E0
 2 153
45 GSE14415 INDUCED TREG VS TCONV DN Genes down-regulated in induced T reg versus T conv. MSigDB C7: Immunologic Signatures (v5.1) 2.137E-3 2.940E-2
2.249E-1
1.000E0
 2 154
46 GSE40274 CTRL VS FOXP3 AND IRF4 TRANSDUCED ACTIVATED CD4 TCELL DN Genes down-regulated in CD4 T conv: control versus over-expression of IRF4 and FOXP3 [GeneID=3662;50943]. MSigDB C7: Immunologic Signatures (v5.1) 2.304E-3 2.940E-2
2.249E-1
1.000E0
 2 160
47 GSE27241 WT VS RORGT KO TH17 POLARIZED CD4 TCELL DN Genes down-regulated in polarizing CD4 [GeneID=920] Th17 cells: wildtype versus RORC [GeneID=6097] knockout. MSigDB C7: Immunologic Signatures (v5.1) 2.506E-3 2.940E-2
2.249E-1
1.000E0
 2 167
48 GSE37605 FOXP3 FUSION GFP VS IRES GFP TREG C57BL6 DN Genes down-regulated in T reg (FOXP3+ [GeneID=50943]) cells from B6 mice: Foxp3-Fusion-GFP versus Foxp3-ires-GFP. MSigDB C7: Immunologic Signatures (v5.1) 2.625E-3 2.940E-2
2.249E-1
1.000E0
 2 171
49 GSE25146 UNSTIM VS HELIOBACTER PYLORI LPS STIM AGS CELL UP Genes up-regulated in AGS cells (gastric adenocarcinoma): control versus H. pylori LPS. MSigDB C7: Immunologic Signatures (v5.1) 2.747E-3 2.940E-2
2.249E-1
1.000E0
 2 175
50 M2708 Genes down-regulated in primary epithelial breast cancer cell culture over-expressing MYC [Gene ID=4609] gene. MSigDB C6: Oncogenic Signatures (v5.1) 2.935E-3 2.940E-2
2.249E-1
1.000E0
 2 181
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 370 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Lungmap Mouse e16.5 Epithelial SubClass Proliferative AT2 Progenitor Top 500 Cluster 0 Mouse Lung E16.5 Epithelial Proliferative AT2 Progenitor c0 Lungmap Mouse Single Cell (Lungmap.net) 2.476E-4 9.040E-3
5.869E-2
9.161E-2
 2 50
2 GSM476675 500 gamma delta T cells, Tgd.Th, TCRd+ CD3e+, Thymus, avg-3 Immgen.org, GSE15907 5.025E-4 9.040E-3
5.869E-2
1.859E-1
 3 349
3 GSM399391 500 alpha beta T cells, T.DP.Th, 4+ 8+ TCR-/lo 69-, Thymus, avg-3 Immgen.org, GSE15907 5.820E-4 9.040E-3
5.869E-2
2.153E-1
 3 367
4 GSM605781 500 gamma delta T cells, Tgd.vg1+vd6-.Th, TCRd+ Vg1.1+, Thymus, avg-3 Immgen.org, GSE15907 6.101E-4 9.040E-3
5.869E-2
2.258E-1
 3 373
5 GSM538207 500 B cells, B.GC.Sp, CD19+ IgM+ IgD- GL7+ PNA+, Spleen, avg-3 Immgen.org, GSE15907 6.441E-4 9.040E-3
5.869E-2
2.383E-1
 3 380
6 GSM605781 100 gamma delta T cells, Tgd.vg1+vd6-.Th, TCRd+ Vg1.1+, Thymus, avg-3 Immgen.org, GSE15907 6.497E-4 9.040E-3
5.869E-2
2.404E-1
 2 81
7 GSM399448 500 B cells, preB.FrD.BM, CD19+ IgM- CD45R+ CD43-, Bone marrow, avg-3 Immgen.org, GSE15907 6.640E-4 9.040E-3
5.869E-2
2.457E-1
 3 384
8 GSM791131 100 B cells, MLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-3 Immgen.org, GSE15907 6.820E-4 9.040E-3
5.869E-2
2.524E-1
 2 83
9 GSM791134 100 alpha beta T cells, preT.DN2-3.Th, Lin-/lo CD25hi CD44Int, Thymus, avg-2 Immgen.org, GSE15907 6.820E-4 9.040E-3
5.869E-2
2.524E-1
 2 83
10 GSM538348 100 B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-2 Immgen.org, GSE15907 6.820E-4 9.040E-3
5.869E-2
2.524E-1
 2 83
11 GSM538387 100 alpha beta T cells, T.8Eff.Sp.OT1.d5.VSVOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 6.820E-4 9.040E-3
5.869E-2
2.524E-1
 2 83
12 GSM538358 100 B cells, proB.FrBC.FL, CD19+ IgM- CD43+ CD24+ AA4.1+ CD45R+, Fetal Liver, avg-3 Immgen.org, GSE15907 7.152E-4 9.040E-3
5.869E-2
2.646E-1
 2 85
13 GSM791154 100 alpha beta T cells, T.DN4.Th, Lin-/lo CD25- CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 7.152E-4 9.040E-3
5.869E-2
2.646E-1
 2 85
14 GSM538340 500 B cells, preB.FrD.FL, AA4.1+ IgM- CD19+ CD43- CD24+, Fetal Liver, avg-3 Immgen.org, GSE15907 7.209E-4 9.040E-3
5.869E-2
2.667E-1
 3 395
15 26Dp Top 500 Cluster 2 26Dp Top 500 Cluster 2 Brain Map - Allen iN 7.320E-4 9.040E-3
5.869E-2
2.708E-1
 2 86
16 GSM399397 500 alpha beta T cells, T.DPbl.Th, 4+ 8+ TCR-/lo FSChi, Thymus, avg-3 Immgen.org, GSE15907 7.423E-4 9.040E-3
5.869E-2
2.747E-1
 3 399
17 GSM538350 100 B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate CD45R- AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 7.490E-4 9.040E-3
5.869E-2
2.771E-1
 2 87
18 GSM791149 100 alpha beta T cells, preT.DN3B.Th, Lin-/lo CD25hi CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 7.490E-4 9.040E-3
5.869E-2
2.771E-1
 2 87
19 GSM791108 500 Stem Cells, SC.MEP.BM, Lineage- Kit+ Sca1- CD34- FcgR-/low, Bone marrow, avg-2 Immgen.org, GSE15907 7.532E-4 9.040E-3
5.869E-2
2.787E-1
 3 401
20 GSM605898 500 alpha beta T cells, T.8Eff.Sp.OT1.d6.LisOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 7.587E-4 9.040E-3
5.869E-2
2.807E-1
 3 402
21 GSM538357 100 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 7.663E-4 9.040E-3
5.869E-2
2.835E-1
 2 88
22 GSM399452 100 B cells, preB.FrC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-3 Immgen.org, GSE15907 7.663E-4 9.040E-3
5.869E-2
2.835E-1
 2 88
23 GSM476660 100 gamma delta T cells, Tgd.vg2+24ahi.e17.Th, TCRd+ Vg2+ CD24+, Fetal Thymus, avg-3 Immgen.org, GSE15907 7.837E-4 9.040E-3
5.869E-2
2.900E-1
 2 89
24 GSM538355 100 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R+ CD, Fetal Liver, avg-2 Immgen.org, GSE15907 7.837E-4 9.040E-3
5.869E-2
2.900E-1
 2 89
25 GSM399452 500 B cells, preB.FrC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-3 Immgen.org, GSE15907 7.977E-4 9.040E-3
5.869E-2
2.951E-1
 3 409
26 GSM399403 100 alpha beta T cells, T.ISP.Th, 4- 8+ TCR-/lo 24hi, Thymus, avg-3 Immgen.org, GSE15907 8.013E-4 9.040E-3
5.869E-2
2.965E-1
 2 90
27 GSM399397 100 alpha beta T cells, T.DPbl.Th, 4+ 8+ TCR-/lo FSChi, Thymus, avg-3 Immgen.org, GSE15907 8.013E-4 9.040E-3
5.869E-2
2.965E-1
 2 90
28 GSM538387 500 alpha beta T cells, T.8Eff.Sp.OT1.d5.VSVOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 8.034E-4 9.040E-3
5.869E-2
2.972E-1
 3 410
29 GSM791122 500 Fetal Liver, SC.STSL.FL, IgM- CD24- CD117+ IL7R- CD150- CD48- AA4.1+ CD43+, Fetal Liver, avg-2 Immgen.org, GSE15907 8.034E-4 9.040E-3
5.869E-2
2.972E-1
 3 410
30 Facebase ST1 e10.5 NeuroEpith CentrlOverEmin 500 e10.5 NeuroEpith CentrlOverEmin top-relative-expression-ranked 500 FaceBase_ST1 8.091E-4 9.040E-3
5.869E-2
2.994E-1
 3 411
31 GSM605793 500 gamma delta T cells, Tgd.vg2+24ahi.Th.TCRbko, TCRd+ Vg2+ CD24+, Thymus, avg-3 Immgen.org, GSE15907 8.148E-4 9.040E-3
5.869E-2
3.015E-1
 3 412
32 GSM476664 500 gamma delta T cells, Tgd.vg3+24alo.e17.Th, TCRd+ Vg3+ CD24-, Fetal Thymus, avg-3 Immgen.org, GSE15907 8.556E-4 9.040E-3
5.869E-2
3.166E-1
 3 419
33 GSM476658 500 gamma delta T cells, Tgd.vg2-24ahi.Th, TCRd+ Vg2- CD24+, Thymus, avg-2 Immgen.org, GSE15907 8.735E-4 9.040E-3
5.869E-2
3.232E-1
 3 422
34 Lungmap Mouse e16.5 Proliferative fibroblast Top 500 Cluster 0 Mouse Lung E16.5 Proliferative fibroblast top 500 c0 Lungmap Mouse Single Cell (Lungmap.net) 8.736E-4 9.040E-3
5.869E-2
3.232E-1
 2 94
35 GSM476655 500 gamma delta T cells, Tgd.vg2+24ahi.Th, TCRd+ Vg2+ CD24+, Thymus, avg-3 Immgen.org, GSE15907 8.796E-4 9.040E-3
5.869E-2
3.254E-1
 3 423
36 GSM791126 500 Fetal Liver, SC.LTSL.FL, IgM- CD24- CD117+ IL7R- CD150+ CD48- AA4.1+ CD43+, Fetal Liver, avg-3 Immgen.org, GSE15907 8.796E-4 9.040E-3
5.869E-2
3.254E-1
 3 423
37 Lungmap Mouse e16.5 Proliferative fibroblast Top 500 All Mouse Lung E16.5 Proliferative fibroblast top 500 Lungmap Mouse Single Cell (Lungmap.net) 1.066E-3 1.066E-2
6.919E-2
3.943E-1
 3 452
38 12Dn Top 500 Cluster 4 12Dn Top 500 Cluster 4 Brain Map - Allen iN 1.348E-3 1.313E-2
8.523E-2
4.989E-1
 2 117
39 PCBC ratio ECTO amniotic fluid MSC vs ECTO blastocyst cfr-2X-p05 ECTO amniotic fluid MSC vs ECTO blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 3.430E-3 3.254E-2
2.113E-1
1.000E0
 2 188
40 Facebase ST1 e10.5 NeuroEpith CentrlOverEmin 250 e10.5 NeuroEpith CentrlOverEmin top-relative-expression-ranked 250 FaceBase_ST1 4.298E-3 3.976E-2
2.581E-1
1.000E0
 2 211
41 PP MEG 2500 K3 PP MEG top-relative-expression-ranked 2500 k-means-cluster#3 PCBC 4.746E-3 4.283E-2
2.780E-1
1.000E0
 2 222
42 Facebase ST1 e9.5 MandibArch 500 4 e9.5 MandibArch top-relative-expression-ranked 500 4 FaceBase_ST1 5.233E-3 4.610E-2
2.993E-1
1.000E0
 1 11
Show 37 more annotations

15: Computational [Display Chart] 74 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GNF2 BUB1 Neighborhood of BUB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.012E-4 6.422E-3 3.139E-2 7.491E-3 2 25
2 GNF2 ESPL1 Neighborhood of ESPL1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.002E-4 6.422E-3 3.139E-2 1.481E-2 2 35
3 GNF2 HMMR Neighborhood of HMMR MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.031E-4 6.422E-3 3.139E-2 2.243E-2 2 43
4 GNF2 BUB1B Neighborhood of BUB1B MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.471E-4 6.422E-3 3.139E-2 2.569E-2 2 46
5 GNF2 CDC20 Neighborhood of CDC20 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.440E-4 6.571E-3 3.212E-2 3.286E-2 2 52
6 GNF2 CCNA2 Neighborhood of CCNA2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.314E-4 7.787E-3 3.806E-2 4.672E-2 2 62
7 module 397 Genes in module 397 MSigDb: C4 - CM: Cancer Modules 2.119E-3 2.240E-2
1.095E-1
1.568E-1
 2 114
Show 2 more annotations

16: MicroRNA [Display Chart] 114 annotations before applied cutoff / 19844 genes in category

No results to display

17: Drug [Display Chart] 2149 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 904 DN 5109870; Down 200; 25uM; MCF7; HT HG-U133A EA Broad Institute CMAP 8.416E-7 3.788E-4 3.125E-3 1.809E-3 4 179
2 3317 DN Ciclopirox ethanolamine [41621-49-2]; Down 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 9.193E-7 3.788E-4 3.125E-3 1.976E-3 4 183
3 5023 DN Ciclopirox ethanolamine [41621-49-2]; Down 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 1.002E-6 3.788E-4 3.125E-3 2.154E-3 4 187
4 5312 DN Monobenzone [103-16-2]; Down 200; 20uM; MCF7; HT HG-U133A Broad Institute CMAP 1.046E-6 3.788E-4 3.125E-3 2.247E-3 4 189
5 1264 DN Thioguanosine [85-31-4]; Down 200; 12.6uM; HL60; HT HG-U133A Broad Institute CMAP 1.160E-6 3.788E-4 3.125E-3 2.494E-3 4 194
6 3689 DN PNU-0251126 [267429-19-6]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 1.160E-6 3.788E-4 3.125E-3 2.494E-3 4 194
7 2932 DN Zalcitabine [7481-89-2]; Down 200; 19uM; HL60; HT HG-U133A Broad Institute CMAP 1.234E-6 3.788E-4 3.125E-3 2.651E-3 4 197
8 1068 UP thioridazine hydrochloride; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 3.918E-5 3.547E-3 2.926E-2
8.419E-2
 3 155
9 C014464 3,4-dichloroaniline CTD 5.250E-5 3.547E-3 2.926E-2
1.128E-1
 3 171
10 C500026 palbociclib CTD 5.342E-5 3.547E-3 2.926E-2
1.148E-1
 3 172
11 7068 DN MG-262; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 5.435E-5 3.547E-3 2.926E-2
1.168E-1
 3 173
12 5489 UP Prenylamine lactate [69-43-2]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP 6.015E-5 3.547E-3 2.926E-2
1.293E-1
 3 179
13 5027 DN Etoposide [33419-42-0]; Down 200; 6.8uM; MCF7; HT HG-U133A Broad Institute CMAP 6.115E-5 3.547E-3 2.926E-2
1.314E-1
 3 180
14 1065 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 6.115E-5 3.547E-3 2.926E-2
1.314E-1
 3 180
15 1661 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 6.320E-5 3.547E-3 2.926E-2
1.358E-1
 3 182
16 7389 DN 0173570-0000 [211245-44-2]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 6.423E-5 3.547E-3 2.926E-2
1.380E-1
 3 183
17 5599 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 6.423E-5 3.547E-3 2.926E-2
1.380E-1
 3 183
18 3241 DN Etoposide [33419-42-0]; Down 200; 6.8uM; MCF7; HT HG-U133A Broad Institute CMAP 6.634E-5 3.547E-3 2.926E-2
1.426E-1
 3 185
19 4365 DN Lycorine hydrochloride [2188-68-3]; Down 200; 12.4uM; MCF7; HT HG-U133A Broad Institute CMAP 6.634E-5 3.547E-3 2.926E-2
1.426E-1
 3 185
20 1668 UP wortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT HG-U133A Broad Institute CMAP 6.634E-5 3.547E-3 2.926E-2
1.426E-1
 3 185
21 3391 DN Monobenzone [103-16-2]; Down 200; 20uM; MCF7; HT HG-U133A Broad Institute CMAP 6.742E-5 3.547E-3 2.926E-2
1.449E-1
 3 186
22 4460 UP LY 294002; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 6.742E-5 3.547E-3 2.926E-2
1.449E-1
 3 186
23 5000 DN Amethopterin (R,S) [59-05-2]; Down 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP 6.742E-5 3.547E-3 2.926E-2
1.449E-1
 3 186
24 6987 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 6.742E-5 3.547E-3 2.926E-2
1.449E-1
 3 186
25 1047 UP 2-propylpentanoic acid; Up 200; 1000uM; MCF7; HT HG-U133A EA Broad Institute CMAP 6.850E-5 3.547E-3 2.926E-2
1.472E-1
 3 187
26 1070 UP troglitazone; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 6.850E-5 3.547E-3 2.926E-2
1.472E-1
 3 187
27 5233 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 6.850E-5 3.547E-3 2.926E-2
1.472E-1
 3 187
28 2000 UP Tolazoline hydrochloride [59-97-2]; Up 200; 20.4uM; HL60; HG-U133A Broad Institute CMAP 6.959E-5 3.547E-3 2.926E-2
1.496E-1
 3 188
29 5493 UP Chlorpromazine hydrochloride [69-09-0]; Up 200; 11.2uM; MCF7; HT HG-U133A Broad Institute CMAP 6.959E-5 3.547E-3 2.926E-2
1.496E-1
 3 188
30 3690 DN 0173570-0000 [211245-44-2]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 7.070E-5 3.547E-3 2.926E-2
1.519E-1
 3 189
31 3214 DN Amethopterin (R,S) [59-05-2]; Down 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP 7.070E-5 3.547E-3 2.926E-2
1.519E-1
 3 189
32 622 DN resveratrol; Down 200; 50uM; MCF7; HG-U133A Broad Institute CMAP 7.182E-5 3.547E-3 2.926E-2
1.543E-1
 3 190
33 1974 DN Pyrimethamine [58-14-0]; Down 200; 16uM; HL60; HG-U133A Broad Institute CMAP 7.182E-5 3.547E-3 2.926E-2
1.543E-1
 3 190
34 328 UP LY294002; Up 200; 10uM; MCF7; HG-U133A Broad Institute CMAP 7.182E-5 3.547E-3 2.926E-2
1.543E-1
 3 190
35 5587 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 7.182E-5 3.547E-3 2.926E-2
1.543E-1
 3 190
36 1986 UP Thioridazine hydrochloride [130-61-0]; Up 200; 9.8uM; HL60; HG-U133A Broad Institute CMAP 7.294E-5 3.547E-3 2.926E-2
1.568E-1
 3 191
37 2865 DN Resveratrol [501-36-0]; Down 200; 17.6uM; MCF7; HT HG-U133A Broad Institute CMAP 7.408E-5 3.547E-3 2.926E-2
1.592E-1
 3 192
38 5509 DN Resveratrol [501-36-0]; Down 200; 17.6uM; MCF7; HT HG-U133A Broad Institute CMAP 7.408E-5 3.547E-3 2.926E-2
1.592E-1
 3 192
39 6136 DN Trifluridine [70-00-8]; Down 200; 13.6uM; HL60; HT HG-U133A Broad Institute CMAP 7.408E-5 3.547E-3 2.926E-2
1.592E-1
 3 192
40 318 UP LY294002; Up 200; 10uM; MCF7; HG-U133A Broad Institute CMAP 7.524E-5 3.547E-3 2.926E-2
1.617E-1
 3 193
41 7388 DN PNU-0251126 [267429-19-6]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 7.524E-5 3.547E-3 2.926E-2
1.617E-1
 3 193
42 3054 DN Monobenzone [103-16-2]; Down 200; 20uM; HL60; HT HG-U133A Broad Institute CMAP 7.524E-5 3.547E-3 2.926E-2
1.617E-1
 3 193
43 971 UP oxaprozin; Up 200; 300uM; MCF7; HT HG-U133A EA Broad Institute CMAP 7.524E-5 3.547E-3 2.926E-2
1.617E-1
 3 193
44 1715 DN Resveratrol [501-36-0]; Down 200; 17.6uM; HL60; HG-U133A Broad Institute CMAP 7.640E-5 3.547E-3 2.926E-2
1.642E-1
 3 194
45 258 UP LY294002; Up 200; 10uM; MCF7; HG-U133A Broad Institute CMAP 7.640E-5 3.547E-3 2.926E-2
1.642E-1
 3 194
46 1632 UP Rapamycin; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 7.640E-5 3.547E-3 2.926E-2
1.642E-1
 3 194
47 573 DN deferoxamine mesylate salt; Down 200; 100uM; MCF7; HG-U133A Broad Institute CMAP 7.757E-5 3.547E-3 2.926E-2
1.667E-1
 3 195
48 5819 DN Trifluridine [70-00-8]; Down 200; 13.6uM; PC3; HT HG-U133A Broad Institute CMAP 7.996E-5 3.580E-3 2.954E-2
1.718E-1
 3 197
49 2533 DN (R) -Naproxen sodium salt [26159-34-2]; Down 200; 15.8uM; HL60; HT HG-U133A Broad Institute CMAP 8.239E-5 3.614E-3 2.981E-2
1.771E-1
 3 199
50 CID000448763 1tom Stitch 2.322E-4 9.981E-3
8.235E-2
4.991E-1
 2 51
Show 45 more annotations

18: Disease [Display Chart] 87 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 613557 DEAFNESS, AUTOSOMAL RECESSIVE 82; DFNB82 OMIM 4.954E-4 1.437E-2
7.253E-2
 4.310E-2 1 1
2 cv:C1858695 Chudley-McCullough syndrome Clinical Variations 4.954E-4 1.437E-2
7.253E-2
 4.310E-2 1 1
3 umls:C1858695 Chudley-Mccullough syndrome DisGeNET Curated 4.954E-4 1.437E-2
7.253E-2
 4.310E-2 1 1
4 umls:C0151546 Oral Cavity Carcinoma DisGeNET BeFree 8.414E-4 1.830E-2
9.240E-2
7.320E-2
 2 90
5 umls:C1708566 Invasive Prostate Carcinoma DisGeNET BeFree 1.485E-3 2.585E-2
1.305E-1
1.292E-1
 1 3