Toppgene analysis for aggregated_1964_log, IC29, positive side

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1: GO: Molecular Function [Display Chart] 366 annotations before applied cutoff / 18819 genes in category

No results to display

2: GO: Biological Process [Display Chart] 2369 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0061518 microglial cell proliferation 2.806E-5 3.323E-2
2.774E-1
6.647E-2
 2 2
2 GO:0061517 macrophage proliferation 2.806E-5 3.323E-2
2.774E-1
6.647E-2
 2 2

3: GO: Cellular Component [Display Chart] 177 annotations before applied cutoff / 19172 genes in category

No results to display

4: Human Phenotype [Display Chart] 374 annotations before applied cutoff / 4410 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 2262 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008023 abnormal styloid process morphology 7.178E-5 4.821E-2
4.002E-1
1.624E-1
 3 12
2 MP:0004538 abnormal maxillary shelf morphology 8.113E-5 4.821E-2
4.002E-1
1.835E-1
 4 33
3 MP:0004204 absent stapes 1.790E-4 4.821E-2
4.002E-1
4.050E-1
 3 16
4 MP:0009655 abnormal secondary palate development 1.795E-4 4.821E-2
4.002E-1
4.061E-1
 6 118
5 MP:0002639 micrognathia 1.817E-4 4.821E-2
4.002E-1
4.110E-1
 5 75
6 MP:0009653 abnormal palate development 2.060E-4 4.821E-2
4.002E-1
4.659E-1
 6 121
7 MP:0000639 abnormal adrenal gland morphology 2.459E-4 4.821E-2
4.002E-1
5.561E-1
 6 125
8 MP:0003756 abnormal hard palate morphology 2.567E-4 4.821E-2
4.002E-1
5.807E-1
 6 126
9 MP:0013550 abnormal secondary palate morphology 2.787E-4 4.821E-2
4.002E-1
6.303E-1
 7 181
10 MP:0004420 parietal bone hypoplasia 2.950E-4 4.821E-2
4.002E-1
6.672E-1
 2 4
11 MP:0014166 ectopic cranial bone 2.950E-4 4.821E-2
4.002E-1
6.672E-1
 2 4
12 MP:0014155 absent olfactory epithelium 2.950E-4 4.821E-2
4.002E-1
6.672E-1
 2 4
13 MP:0003056 abnormal hyoid bone morphology 3.019E-4 4.821E-2
4.002E-1
6.829E-1
 4 46
14 MP:0004418 small parietal bone 3.051E-4 4.821E-2
4.002E-1
6.902E-1
 3 19
15 MP:0010282 decreased organ/body region tumor incidence 3.282E-4 4.821E-2
4.002E-1
7.425E-1
 4 47
16 MP:0002820 abnormal premaxilla morphology 3.562E-4 4.821E-2
4.002E-1
8.057E-1
 4 48
17 MP:0003755 abnormal palate morphology 3.623E-4 4.821E-2
4.002E-1
8.196E-1
 9 316
18 MP:0009907 decreased tongue size 4.145E-4 4.849E-2
4.026E-1
9.377E-1
 3 21
19 MP:0009891 abnormal palate bone morphology 4.171E-4 4.849E-2
4.026E-1
9.435E-1
 4 50
20 MP:0013545 cleft hard palate 4.487E-4 4.849E-2
4.026E-1
1.000E0
 5 91
21 MP:0009888 palatal shelves fail to meet at midline 4.502E-4 4.849E-2
4.026E-1
1.000E0
 4 51
Show 16 more annotations

6: Domain [Display Chart] 677 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF01661 Macro Pfam 1.175E-5 2.830E-3 2.008E-2 7.954E-3 3 9
2 SM00506 A1pp SMART 1.175E-5 2.830E-3 2.008E-2 7.954E-3 3 9
3 PS51154 MACRO PROSITE 1.672E-5 2.830E-3 2.008E-2 1.132E-2 3 10
4 IPR002589 Macro dom InterPro 1.672E-5 2.830E-3 2.008E-2 1.132E-2 3 10
5 IPR012346 p53/RUNT-type TF DNA-bd InterPro 4.089E-4 3.614E-2
2.564E-1
2.769E-1
 2 6
6 2.60.40.720 - Gene3D 4.089E-4 3.614E-2
2.564E-1
2.769E-1
 2 6
7 IPR033906 Lipase N InterPro 1.210E-3 3.614E-2
2.564E-1
8.192E-1
 2 10
8 IPR000734 TAG lipase InterPro 1.210E-3 3.614E-2
2.564E-1
8.192E-1
 2 10
9 PF15040 Humanin Pfam 1.210E-3 3.614E-2
2.564E-1
8.192E-1
 2 10
10 PF00151 Lipase Pfam 1.210E-3 3.614E-2
2.564E-1
8.192E-1
 2 10
11 IPR028139 Humanin InterPro 1.210E-3 3.614E-2
2.564E-1
8.192E-1
 2 10
12 IPR016272 Lipase LIPH InterPro 1.210E-3 3.614E-2
2.564E-1
8.192E-1
 2 10
13 IPR013818 Lipase/vitellogenin InterPro 1.210E-3 3.614E-2
2.564E-1
8.192E-1
 2 10
14 PS00061 ADH SHORT PROSITE 2.769E-3 3.614E-2
2.564E-1
1.000E0
 3 53
15 PF00106 adh short Pfam 3.077E-3 3.614E-2
2.564E-1
1.000E0
 3 55
16 IPR002347 SDR fam InterPro 3.239E-3 3.614E-2
2.564E-1
1.000E0
 3 56
17 PF00644 PARP Pfam 3.570E-3 3.614E-2
2.564E-1
1.000E0
 2 17
18 PS51059 PARP CATALYTIC PROSITE 3.570E-3 3.614E-2
2.564E-1
1.000E0
 2 17
19 3.90.228.10 - Gene3D 3.570E-3 3.614E-2
2.564E-1
1.000E0
 2 17
20 IPR012317 Poly(ADP-ribose)pol cat dom InterPro 3.570E-3 3.614E-2
2.564E-1
1.000E0
 2 17
21 IPR028860 CCNG1 InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
22 PS00437 CATALASE 1 PROSITE 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
23 IPR018888 UPF0561 InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
24 IPR033094 RBM5 InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
25 IPR029602 IFT74 InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
26 IPR018793 Cyt c oxidase assmbl Pet191 InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
27 PF05889 SepSecS Pfam 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
28 IPR024711 Catalase clade1/3 InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
29 IPR028647 ING4 InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
30 SM01060 Catalase SMART 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
31 PS51402 CATALASE 3 PROSITE 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
32 IPR032969 DHRS3 InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
33 IPR003829 Pirin N dom InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
34 PD019364 PD019364 ProDom 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
35 IPR028314 DP-2 InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
36 PF15095 IL33 Pfam 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
37 PF15053 Njmu-R1 Pfam 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
38 PS01184 UBIE 2 PROSITE 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
39 PF05458 Siva Pfam 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
40 IPR002226 Catalase haem BS InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
41 IPR028843 Ang-1 InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
42 IPR008829 SepSecS/SepCysS InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
43 IPR027290 PDGFRA InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
44 PF08563 P53 TAD Pfam 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
45 IPR012213 IGFBP-5 InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
46 PS01183 UBIE 1 PROSITE 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
47 IPR028280 Njmu-R1 InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
48 PS51608 SAM MT UBIE PROSITE 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
49 PF00199 Catalase Pfam 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
50 IPR033832 PEDF InterPro 5.284E-3 3.614E-2
2.564E-1
1.000E0
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 522 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 106156 Lipoprotein metabolism BioSystems: REACTOME 1.543E-5 8.057E-3
5.508E-2
 8.057E-3 4 29
2 523016 Transcriptional misregulation in cancer BioSystems: KEGG 4.211E-5 1.077E-2
7.363E-2
 2.198E-2 7 179
3 106158 HDL-mediated lipid transport BioSystems: REACTOME 6.190E-5 1.077E-2
7.363E-2
 3.231E-2 3 15
4 106111 Lipid digestion, mobilization, and transport BioSystems: REACTOME 1.272E-4 1.660E-2
1.135E-1
6.641E-2
 4 49

8: Pubmed [Display Chart] 27430 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16770077 Concordant association of lipid gene variation with a combined HDL/LDL-cholesterol phenotype in two European populations. Pubmed 8.779E-7 2.102E-3 2.269E-2 2.408E-2 3 10
2 16770077:gr Concordant association of lipid gene variation with a combined HDL/LDL-cholesterol phenotype in two European populations. GeneRIF 8.779E-7 2.102E-3 2.269E-2 2.408E-2 3 10
3 12966036 Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors. Pubmed 8.779E-7 2.102E-3 2.269E-2 2.408E-2 3 10
4 18287097 An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
5 21187071:gr AMP-activated protein kinase (AMPK) positively regulates osteoblast differentiation via induction of Dlx5-dependent Runx2 expression in MC3T3E1 cells. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
6 23360829 Association between polymorphisms in the genes for tumor suppressor protein p53 and its regulator NAD(P)H: quinone oxidoreductase 1 (NQO1) and schizophrenia in a Syrian study cohort. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
7 17804819:gr Induction of cellular senescence by insulin-like growth factor binding protein-5 through a p53-dependent mechanism. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
8 19995558 LMO3 interacts with p53 and inhibits its transcriptional activity. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
9 20952507:gr p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
10 17982131 Genomic and proteomic profiles reveal the association of gelsolin to TP53 status and bladder cancer progression. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
11 15882981:gr Nuclear localization signal of ING4 plays a key role in its binding to p53. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
12 18069692:gr The macroPARP genes Parp-9 and Parp-14 are developmentally and differentially regulated in mouse tissues. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
13 18930016:gr 4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
14 17785557:gr CXCL12 G801A polymorphism is a risk factor for sporadic prostate cancer susceptibility. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
15 23468244 Association between polymorphisms in apoptotic genes and susceptibility for developing breast cancer in Syrian women. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
16 21801713:gr Gelsolin negatively regulates the activity of tumor suppressor p53 through their physical interaction in hepatocarcinoma HepG2 cells. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
17 18385452:gr Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
18 19147556:gr p18Ink4c and p53 Act as tumor suppressors in cyclin D1-driven primitive neuroectodermal tumor. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
19 25993310 Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
20 23360829:gr Association between polymorphisms in the genes for tumor suppressor protein p53 and its regulator NAD(P)H: quinone oxidoreductase 1 (NQO1) and schizophrenia in a Syrian study cohort. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
21 19688691:gr Analysis of NQO1 polymorphisms and p53 protein expression in patients with hepatocellular carcinoma. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
22 14634213:gr P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
23 11511362 p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
24 19995558:gr LMO3 interacts with p53 and inhibits its transcriptional activity. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
25 18385452 Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
26 21659514:gr p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
27 23967213 The ING4 Binding with p53 and Induced p53 Acetylation were Attenuated by Human Papillomavirus 16 E6. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
28 17785557 CXCL12 G801A polymorphism is a risk factor for sporadic prostate cancer susceptibility. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
29 17982131:gr Genomic and proteomic profiles reveal the association of gelsolin to TP53 status and bladder cancer progression. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
30 15882981 Nuclear localization signal of ING4 plays a key role in its binding to p53. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
31 23468244:gr Association between polymorphisms in apoptotic genes and susceptibility for developing breast cancer in Syrian women. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
32 26925584 A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
33 24608790 Oxidative stress-induced p53 activity is enhanced by a redox-sensitive TP53INP1 SUMOylation. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
34 21801713 Gelsolin negatively regulates the activity of tumor suppressor p53 through their physical interaction in hepatocarcinoma HepG2 cells. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
35 22033922 Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
36 22033922:gr Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
37 21307125:gr p53 target Siva regulates apoptosis in ischemic kidneys. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
38 17804819 Induction of cellular senescence by insulin-like growth factor binding protein-5 through a p53-dependent mechanism. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
39 20309933:gr p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
40 23066387:gr Association study of genes associated to asthma in a specific environment, in an asthma familial collection located in a rural area influenced by different industries. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
41 18287097:gr An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
42 16192291 Ultrasonography for rheumatologists: the development of specific competency based educational outcomes. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
43 18511948 NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
44 23066387 Association study of genes associated to asthma in a specific environment, in an asthma familial collection located in a rural area influenced by different industries. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
45 12529318 Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
46 19688691 Analysis of NQO1 polymorphisms and p53 protein expression in patients with hepatocellular carcinoma. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
47 14559902:gr Phospholipid transfer protein interacts with and stabilizes ATP-binding cassette transporter A1 and enhances cholesterol efflux from cells. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
48 23653000 CXCL12 and TP53 genetic polymorphisms as markers of susceptibility in a Brazilian children population with acute lymphoblastic leukemia (ALL). Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
49 20309933 p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5. Pubmed 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
50 21357737:gr Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. GeneRIF 3.832E-6 2.102E-3 2.269E-2
1.051E-1
 2 2
Show 45 more annotations

9: Interaction [Display Chart] 2447 annotations before applied cutoff / 16534 genes in category

No results to display

10: Cytoband [Display Chart] 93 annotations before applied cutoff / 34661 genes in category

No results to display

11: Transcription Factor Binding Site [Display Chart] 451 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$SOX5 01 V$SOX5 01 7.512E-5 3.388E-2
2.266E-1
 3.388E-2 8 212

12: Gene Family [Display Chart] 69 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 21 Non-clustered protocadherins genenames.org 8.356E-4 4.928E-2
2.375E-1
5.765E-2
 2 12
2 684 Zinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases genenames.org 1.702E-3 4.928E-2
2.375E-1
1.174E-1
 2 17
3 743 Short chain dehydrogenase/reductase superfamily genenames.org 2.654E-3 4.928E-2
2.375E-1
1.831E-1
 3 76
4 464 Lipases genenames.org 2.857E-3 4.928E-2
2.375E-1
1.971E-1
 2 22

13: Coexpression [Display Chart] 5126 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5793 Down-regulated genes in the canonical gene expression signature of the fibroblast core serum response (CSR) defined by the Stanford group. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.395E-10 6.961E-7 6.348E-6 1.228E-6 12 209
2 M13276 Genes down-regulated by IL2 [GeneID=3558] in cells derived from CD4+ [GeneID=920] cutaneous T-cell lymphoma (CTCL). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.716E-10 6.961E-7 6.348E-6 1.392E-6 7 36
3 M2446 Genes down-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 10 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.410E-9 2.409E-6 2.197E-5 7.227E-6 12 244
4 M988 Genes up-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.330E-9 2.608E-6 2.378E-5 1.194E-5 10 153
5 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.893E-9 2.608E-6 2.378E-5 1.483E-5 12 260
6 M2081 Genes down-regulated by TGFB1 [GeneID=7040] in MEF cells (embryonic fibroblast) via TGFB1R [GeneID=7046]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.166E-9 2.608E-6 2.378E-5 1.623E-5 11 207
7 M13206 Genes down-regulated in TC71 and EWS502 cells (Ewing's sarcoma) by EWSR1-FLI1 [GeneID=2130;2314] as inferred from RNAi knockdown of this fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.561E-9 2.608E-6 2.378E-5 1.825E-5 13 326
8 M12225 Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.854E-8 2.469E-5 2.252E-4 1.975E-4 10 205
9 M2143 Genes down-regulated in SH-SY5Y cells (neuroblastoma) after knockdown of NF1 [GeneID=4763] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.749E-8 3.274E-5 2.986E-4 2.947E-4 8 114
10 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.152E-8 4.179E-5 3.811E-4 4.179E-4 13 425
11 M12004 Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of both HDAC1 and HDAC2 [GeneID=3065;3066] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.182E-7 5.508E-5 5.023E-4 6.059E-4 10 231
12 M13867 Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.063E-7 1.308E-4 1.193E-3 1.570E-3 10 256
13 M6100 Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC1 [GeneID=3065] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.409E-7 1.344E-4 1.226E-3 1.748E-3 10 259
14 M4932 Genes up-regulated in HeLa cells (cervical carcinoma) by trabectedin [PubChem=3199]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.640E-7 2.431E-4 2.217E-3 3.404E-3 6 67
15 M14877 Genes down-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [GeneID=4904] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.601E-6 5.471E-4 4.989E-3 8.206E-3 11 383
16 M2756 Genes up-regulated in CEM-C1 cells (T-CLL) by everolimus [PubChem = 6442177], an mTOR pathway inhibitor. MSigDB C6: Oncogenic Signatures (v5.1) 2.733E-6 8.571E-4 7.816E-3 1.401E-2 8 189
17 M13256 Genes down-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.843E-6 8.571E-4 7.816E-3 1.457E-2 8 190
18 GSE36826 WT VS IL1R KO SKIN UP Genes up-regulated in skin: wildtype versus IL1R1 [GeneID=3554] knockout. MSigDB C7: Immunologic Signatures (v5.1) 4.006E-6 1.122E-3 1.023E-2 2.053E-2 8 199
19 M5905 Genes up-regulated during adipocyte differentiation (adipogenesis). MSigDB H: Hallmark Gene Sets (v5.1) 4.157E-6 1.122E-3 1.023E-2 2.131E-2 8 200
20 M15981 Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.861E-6 1.246E-3 1.136E-2 2.492E-2 11 430
21 M18077 Genes up-regulated in immunoglobulin light chain amyloidosis plasma cells (ALPC) compared to multiple myeloma (MM) cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.927E-6 1.447E-3 1.319E-2 3.038E-2 4 26
22 M10290 Genes up-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.430E-6 1.731E-3 1.579E-2 3.809E-2 6 101
23 M19620 Genes down-regulated in 293T (transformed fetal renal cell) upon expression of MYC [GeneID=4609]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.873E-6 1.755E-3 1.600E-2 4.036E-2 3 9
24 M1914 Genes up-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.754E-6 1.870E-3 1.705E-2 4.487E-2 9 293
25 M2581 Genes up-regulated in the HSC supportive stromal cell lines. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.757E-6 2.001E-3 1.824E-2
5.002E-2
 9 297
26 M4995 Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.318E-5 2.599E-3 2.370E-2
6.757E-2
 10 390
27 M7514 Genes down-regulated in NIH3T3 cells (fibroblasts) transformed by expression of contitutively active (Q63L) form of RHOA [GeneID=387] off plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.440E-5 2.733E-3 2.492E-2
7.379E-2
 10 394
28 M16108 Genes down-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402], a protease inhibitor causing apoptosis. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.523E-5 2.783E-3 2.538E-2
7.808E-2
 7 172
29 M18168 Genes up-regulated in MEF cells (embryonic fibroblast) isolated from NRAS [GeneID=4893] knockout mice. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.575E-5 2.783E-3 2.538E-2
8.071E-2
 5 68
30 M15927 Genes down-regulated in HCT8/S1 cells (colon cancer) which normally lack DCC [GeneID=9423] compared to those stably expressing wild type DCC off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.092E-5 3.574E-3 3.260E-2
1.072E-1
 6 121
31 M10355 Genes up-regulated in MCV152 cells (ovarian cancer) treated with follicle stimulating hormone (FSH). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.380E-5 3.936E-3 3.590E-2
1.220E-1
 5 74
32 M3654 Genes up-regulated in samples with systolic heart failure compared to normal hearts. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.591E-5 3.937E-3 3.590E-2
1.328E-1
 10 422
33 M2666 Genes down-regulated in mouse prostate by transgenic expression of human AKT1 gene [Gene ID=207] vs controls. MSigDB C6: Oncogenic Signatures (v5.1) 2.611E-5 3.937E-3 3.590E-2
1.339E-1
 7 187
34 M2684 Genes down-regulated in myometrial cells over-expressing ATF2 [Gene ID=1386] gene. MSigDB C6: Oncogenic Signatures (v5.1) 2.611E-5 3.937E-3 3.590E-2
1.339E-1
 7 187
35 M1522 Genes up-regulated in MEF cells (embryonic fibroblast) lacking TP53 and BRCA1 [GeneID=7157;672] by expression of TP53; most genes are further up-regulated by simultaneous expression of BRCA1. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.805E-5 4.108E-3 3.746E-2
1.438E-1
 4 38
36 M1610 All significantly up-regulated genes in kidney glomeruli isolated from TCF21 [Gene ID=6943] knockout mice. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.921E-5 4.160E-3 3.793E-2
1.498E-1
 10 428
37 M2370 Oligodendrocyte core differentiation genes: up-regulated in Oli-neo cells (oligodendroglial precursor) at 10 h after treatment with PD174265, dexamethasone or isotretinoin [PubChemID=4709, 5743, 5282379]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.448E-5 4.524E-3 4.125E-2
1.767E-1
 4 40
38 M6899 Genes up-regulated in macrophages with IL10 [GeneID=3586] knockout in response to 10 min treatment by: LPS versus LPS and IL10 [GeneID=3586]. MSigDB C7: Immunologic Signatures (v5.1) 3.527E-5 4.524E-3 4.125E-2
1.808E-1
 7 196
39 GSE46606 UNSTIM VS CD40L IL2 IL5 DAY1 STIMULATED BCELL UP Genes up-regulated in at day 0 B cell wildtype versus CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell wildtype. MSigDB C7: Immunologic Signatures (v5.1) 3.762E-5 4.524E-3 4.125E-2
1.929E-1
 7 198
40 GSE46606 UNSTIM VS CD40L IL2 IL5 DAY3 STIMULATED BCELL UP Genes up-regulated in at day 0 B cell wildtype versus CD40L and IL-2 IL-4 IL-5 stimulated at day 3 B cell wildtype. MSigDB C7: Immunologic Signatures (v5.1) 3.762E-5 4.524E-3 4.125E-2
1.929E-1
 7 198
41 GSE19888 ADENOSINE A3R INH VS TCELL MEMBRANES ACT MAST CELL UP Genes up-regulated in HMC-1 (mast leukemia) cells: incubated with the peptide ALL1 versus stimulated with T cell membranes. MSigDB C7: Immunologic Signatures (v5.1) 3.885E-5 4.524E-3 4.125E-2
1.991E-1
 7 199
42 GSE45739 NRAS KO VS WT ACD3 ACD28 STIM CD4 TCELL DN Genes down-regulated in activated CD4 [GeneID=920] T cells: NRAS [GeneID=4893] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v5.1) 3.885E-5 4.524E-3 4.125E-2
1.991E-1
 7 199
43 M6827 Genes up-regulated in dendritic cells versus monocytes. MSigDB C7: Immunologic Signatures (v5.1) 4.011E-5 4.524E-3 4.125E-2
2.056E-1
 7 200
44 GSE21380 NON TFH VS TFH CD4 TCELL DN Genes down-regulated in CD4 [GeneID=920] T cells: non-Tfh versus Tfh (T follicular helper). MSigDB C7: Immunologic Signatures (v5.1) 4.011E-5 4.524E-3 4.125E-2
2.056E-1
 7 200
45 GSE22935 WT VS MYD88 KO MACROPHAGE DN Genes down-regulated in macrophages: wildtype versus MYD88 [GeneID=4615] knockout. MSigDB C7: Immunologic Signatures (v5.1) 4.011E-5 4.524E-3 4.125E-2
2.056E-1
 7 200
46 M2013 Genes with low-CpG-density promoters (LCP) bearing histone H3 trimethylation mark at K4 (H3K4me3) in neural progenitor cells (NPC). MSigDB C2: CGP Curated Gene Sets (v5.1) 4.059E-5 4.524E-3 4.125E-2
2.081E-1
 10 445
47 M2259 Partial list of genes up-regulated in the kidney of GLIS2 [GeneID=84662] knockout mice compared to the wild type. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.399E-5 4.797E-3 4.375E-2
2.255E-1
 5 84
48 M19130 Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 16 h time point that were not down-regulated at the previous time point, 14 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.926E-5 5.261E-3 4.797E-2
2.525E-1
 5 86
49 M10381 Genes down-regulated in transformed NIH3T3 cells (fibroblasts transformed by activated KRAS [GeneID=3845]) vs normal cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.151E-5 5.389E-3 4.914E-2
2.640E-1
 6 142
50 M8617 Potential direct target genes for MIR34A [GeneID=407040] microRNA in IMR32 cells (neuroblastoma). MSigDB C2: CGP Curated Gene Sets (v5.1) 6.014E-5 6.165E-3
5.622E-2
3.083E-1
 6 146
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2496 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 2.630E-13 6.565E-10 5.514E-9 6.565E-10 20 494
2 26Dn Top 500 All 26Dn Top 500 All Brain Map - Allen iN 2.939E-12 3.668E-9 3.081E-8 7.336E-9 19 496
3 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 2.586E-11 2.152E-8 1.808E-7 6.456E-8 18 493
4 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 3.786E-11 2.363E-8 1.985E-7 9.451E-8 17 438
5 gudmap dev gonad e13.5 M InterstitTestis Sma 500 dev gonad e13.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.410E-10 1.047E-7 8.797E-7 6.015E-7 15 362
6 endothelial SubClass DCN-hi Top 500 All endothelial SubClass DCN-hi Top 500 All Brain Map - Barres 2.517E-10 1.047E-7 8.797E-7 6.283E-7 17 495
7 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 5.963E-10 2.126E-7 1.786E-6 1.488E-6 16 453
8 26Dn Top 500 Cluster 0 26Dn Top 500 Cluster 0 Brain Map - Allen iN 9.703E-10 3.027E-7 2.543E-6 2.422E-6 9 96
9 26Dn SubClass 26Dn 1 Top 500 All 26Dn SubClass 26Dn 1 Top 500 All Brain Map - Allen iN 1.795E-9 4.919E-7 4.132E-6 4.481E-6 16 489
10 gudmap dev gonad e13.5 M InterstitFLeydig MafB 500 dev gonad e13.5 M InterstitFLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.971E-9 4.919E-7 4.132E-6 4.919E-6 14 356
11 gudmap dev gonad e12.5 M InterstitTestis Sma 500 dev gonad e12.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.707E-9 8.412E-7 7.066E-6 9.253E-6 14 374
12 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 5.479E-9 1.140E-6 9.572E-6 1.367E-5 15 455
13 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 7.768E-9 1.491E-6 1.253E-5 1.939E-5 15 467
14 gudmap kidney P0 CapMes Crym k2 1000 kidney P0 CapMes Crym k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 8.367E-9 1.492E-6 1.253E-5 2.088E-5 8 85
15 gudmap dev gonad e11.5 M GonadVasMes Flk 500 dev gonad e11.5 M GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.563E-8 2.601E-6 2.185E-5 3.902E-5 14 419
16 gudmap dev gonad e11.5 F GonadVasMes Flk 500 dev gonad e11.5 F GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.814E-8 2.826E-6 2.374E-5 4.528E-5 14 424
17 gudmap developingKidney e15.5 Peripheral blastema 1000 k2 DevelopingKidney e15.5 Peripheral blastema emap-27731 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.925E-8 2.826E-6 2.374E-5 4.804E-5 11 234
18 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 3.318E-8 4.601E-6 3.865E-5 8.281E-5 14 445
19 gudmap dev gonad e13.5 M InterstitFLeydig MafB 200 dev gonad e13.5 M InterstitFLeydig MafB top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 3.958E-8 5.199E-6 4.367E-5 9.878E-5 9 146
20 54Dn SubClass 54Dn 1SK Top 500 Cluster 2 54Dn SubClass 54Dn 1SK Top 500 Cluster 2 Brain Map - Allen iN 6.873E-8 8.578E-6 7.205E-5 1.716E-4 11 265
21 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.755E-8 1.159E-5 9.739E-5 2.435E-4 13 410
22 54Dn Top 500 Cluster 1 54Dn Top 500 Cluster 1 Brain Map - Allen iN 1.078E-7 1.224E-5 1.028E-4 2.692E-4 9 164
23 astrocytes Top 500 All astrocytes Top 500 All Brain Map - Barres 1.264E-7 1.372E-5 1.153E-4 3.156E-4 14 496
24 gudmap dev gonad e11.5 F GonadVasMes Flk k3 1000 dev gonad e11.5 F GonadVasMes Flk k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.583E-7 1.590E-5 1.336E-4 3.951E-4 12 355
25 gudmap developingKidney e14.5 whole kidney - Wnt4 KO 1000 k5 DevelopingKidney e14.5 whole kidney - Wnt4 KO emap-6674 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.593E-7 1.590E-5 1.336E-4 3.976E-4 11 288
26 endothelial SubClass DCN-hi Top 500 Cluster 1 endothelial SubClass DCN-hi Top 500 Cluster 1 Brain Map - Barres 1.978E-7 1.894E-5 1.591E-4 4.937E-4 10 232
27 GSM777055 100 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 2.049E-7 1.894E-5 1.591E-4 5.114E-4 7 86
28 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma 500 dev gonad e13.5 F VascAssocMesenchStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.692E-7 2.399E-5 2.015E-4 6.718E-4 12 373
29 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 3.734E-7 3.214E-5 2.700E-4 9.320E-4 13 461
30 gudmap dev gonad e13.5 M InterstitFLeydig MafB k3 1000 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 7.367E-7 5.984E-5 5.026E-4 1.839E-3 11 336
31 gudmap developingKidney e15.5 Peripheral blastema 500 k2 DevelopingKidney e15.5 Peripheral blastema emap-27731 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.432E-7 5.984E-5 5.026E-4 1.855E-3 9 206
32 gudmap dev gonad e11.5 M GonadVasMes Flk k4 500 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.056E-7 6.284E-5 5.278E-4 2.011E-3 9 208
33 54Dn SubClass 54Dn 2 Top 500 All 54Dn SubClass 54Dn 2 Top 500 All Brain Map - Allen iN 8.321E-7 6.293E-5 5.286E-4 2.077E-3 13 495
34 26Dn SubClass 26Dn 2 Top 500 All 26Dn SubClass 26Dn 2 Top 500 All Brain Map - Allen iN 8.902E-7 6.535E-5 5.489E-4 2.222E-3 13 498
35 gudmap dev gonad e13.5 M InterstitTestis Sma k1 500 dev gonad e13.5 M InterstitTestis Sma k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 9.494E-7 6.721E-5 5.645E-4 2.370E-3 8 156
36 gudmap developingKidney e15.5 Peripheral blastema 500 DevelopingKidney e15.5 Peripheral blastema emap-27731 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.693E-7 6.721E-5 5.645E-4 2.419E-3 12 421
37 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB 500 dev gonad e13.5 F VascAssocMesenchStromOvary MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.369E-6 9.236E-5 7.758E-4 3.417E-3 11 358
38 gudmap dev gonad e12.5 M InterstitLeydig MafB 500 dev gonad e12.5 M InterstitLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.609E-6 1.031E-4 8.658E-4 4.016E-3 11 364
39 Lungmap Mouse e16.5 Proliferative fibroblast SubClass Proliferative Myofibroblast Top 500 All Mouse Lung E16.5 Proliferative Myofibroblast top500 Lungmap Mouse Single Cell (Lungmap.net) 1.611E-6 1.031E-4 8.658E-4 4.020E-3 12 442
40 80Dn Top 500 Cluster 2 80Dn Top 500 Cluster 2 Brain Map - Allen iN 1.922E-6 1.199E-4 1.008E-3 4.798E-3 9 231
41 gudmap dev gonad e12.5 M InterstitLeydig MafB k1 1000 dev gonad e12.5 M InterstitLeydig MafB k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.841E-6 1.729E-4 1.453E-3 7.091E-3 10 311
42 gudmap dev gonad e13.5 M InterstitFLeydig MafB k3 200 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 2.961E-6 1.760E-4 1.478E-3 7.391E-3 6 82
43 GSM777050 100 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 4.188E-6 2.431E-4 2.042E-3 1.045E-2 6 87
44 80Dn SubClass 80Dn 1 Top 500 All 80Dn SubClass 80Dn 1 Top 500 All Brain Map - Allen iN 4.553E-6 2.525E-4 2.121E-3 1.136E-2 12 489
45 80Dn SubClass 80Dn 1 Top 500 Cluster 0 80Dn SubClass 80Dn 1 Top 500 Cluster 0 Brain Map - Allen iN 4.553E-6 2.525E-4 2.121E-3 1.136E-2 12 489
46 astrocytes Top 500 Cluster 1 astrocytes Top 500 Cluster 1 Brain Map - Barres 4.658E-6 2.528E-4 2.123E-3 1.163E-2 8 193
47 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 500 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.812E-6 2.556E-4 2.147E-3 1.201E-2 11 408
48 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k3 1000 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.219E-6 2.714E-4 2.280E-3 1.303E-2 8 196
49 80Dn Top 500 Cluster 1 80Dn Top 500 Cluster 1 Brain Map - Allen iN 5.798E-6 2.922E-4 2.454E-3 1.447E-2 6 92
50 gudmap dev gonad e11.5 M GonadVasMes Flk k1 1000 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 5.931E-6 2.922E-4 2.454E-3 1.480E-2 10 338
Show 45 more annotations

15: Computational [Display Chart] 281 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 3.520E-4 4.744E-2
2.949E-1
9.891E-2
 10 361
2 module 19 Genes in module 19 MSigDb: C4 - CM: Cancer Modules 4.722E-4 4.744E-2
2.949E-1
1.327E-1
 9 307
3 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 5.064E-4 4.744E-2
2.949E-1
1.423E-1
 10 378
4 module 60 Genes in module 60 MSigDb: C4 - CM: Cancer Modules 9.508E-4 4.931E-2
3.066E-1
2.672E-1
 10 410
5 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 1.174E-3 4.931E-2
3.066E-1
3.298E-1
 7 216
6 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 1.206E-3 4.931E-2
3.066E-1
3.388E-1
 10 423
7 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 1.228E-3 4.931E-2
3.066E-1
3.452E-1
 9 351
Show 2 more annotations

16: MicroRNA [Display Chart] 1065 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1225-5p:mirSVR highEffct hsa-miR-1225-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.032E-6 4.294E-3 3.242E-2 4.294E-3 11 391

17: Drug [Display Chart] 18304 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1242 UP Rapamycin; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.460E-8 1.146E-4 1.191E-3 2.672E-4 10 187
2 D007654 Ketoconazole CTD 1.862E-8 1.146E-4 1.191E-3 3.407E-4 11 248
3 1221 UP Rapamycin; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.878E-8 1.146E-4 1.191E-3 3.437E-4 10 192
4 C488369 dasatinib CTD 2.415E-7 9.277E-4 9.641E-3 4.420E-3 13 472
5 D000069439 Dasatinib CTD 2.534E-7 9.277E-4 9.641E-3 4.639E-3 13 474
6 D015073 2-Acetylaminofluorene CTD 3.178E-7 9.695E-4 1.007E-2 5.817E-3 12 403
7 D004002 Clodronic Acid CTD 1.642E-6 4.294E-3 4.462E-2 3.006E-2 9 241
8 4456 DN troglitazone; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 2.433E-6 5.566E-3
5.785E-2
 4.453E-2 8 188
9 C004532 benzoquinone CTD 3.956E-6 8.046E-3
8.361E-2
7.241E-2
 5 52
10 CID000007898 2-cyanoacetamide Stitch 9.645E-6 1.562E-2
1.623E-1
1.765E-1
 7 162
11 C004656 chloroacetaldehyde CTD 1.110E-5 1.562E-2
1.623E-1
2.032E-1
 9 305
12 D015056 1-Methyl-3-isobutylxanthine CTD 1.232E-5 1.562E-2
1.623E-1
2.255E-1
 10 391
13 7068 DN MG-262; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.479E-5 1.562E-2
1.623E-1
2.707E-1
 7 173
14 C017363 hexabromobenzene CTD 1.489E-5 1.562E-2
1.623E-1
2.725E-1
 3 11
15 3993 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.715E-5 1.562E-2
1.623E-1
3.139E-1
 7 177
16 1636 UP retinoic acid; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.778E-5 1.562E-2
1.623E-1
3.255E-1
 7 178
17 D010656 Phenylephrine CTD 1.810E-5 1.562E-2
1.623E-1
3.314E-1
 11 500
18 D019826 Cholic Acid CTD 1.850E-5 1.562E-2
1.623E-1
3.387E-1
 5 71
19 D010630 Phenindione CTD 2.068E-5 1.562E-2
1.623E-1
3.786E-1
 2 2
20 C120489 oligofructose CTD 2.068E-5 1.562E-2
1.623E-1
3.786E-1
 2 2
21 C057862 cyanoginosin LR CTD 2.134E-5 1.562E-2
1.623E-1
3.906E-1
 8 253
22 C487081 belinostat CTD 2.142E-5 1.562E-2
1.623E-1
3.921E-1
 10 417
23 C583074 4,4'-hexafluorisopropylidene diphenol CTD 2.165E-5 1.562E-2
1.623E-1
3.963E-1
 6 123
24 1081 UP wortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT HG-U133A EA Broad Institute CMAP 2.202E-5 1.562E-2
1.623E-1
4.031E-1
 7 184
25 D016559 Tacrolimus CTD 2.445E-5 1.562E-2
1.623E-1
4.475E-1
 9 337
26 3770 DN Helveticoside [630-64-8]; Down 200; 7.4uM; PC3; HT HG-U133A Broad Institute CMAP 2.616E-5 1.562E-2
1.623E-1
4.788E-1
 7 189
27 6809 UP Labetalol hydrochloride [32780-64-6]; Up 200; 11uM; MCF7; HT HG-U133A Broad Institute CMAP 2.991E-5 1.562E-2
1.623E-1
5.475E-1
 7 193
28 5603 UP wortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT HG-U133A Broad Institute CMAP 2.991E-5 1.562E-2
1.623E-1
5.475E-1
 7 193
29 5932 UP rapamycin, Streptomyces hygroscepicus; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 3.092E-5 1.562E-2
1.623E-1
5.659E-1
 7 194
30 4232 DN Salsolinol hydrobromide [38221-21-5]; Down 200; 15.4uM; PC3; HT HG-U133A Broad Institute CMAP 3.092E-5 1.562E-2
1.623E-1
5.659E-1
 7 194
31 D009243 NAD CTD 3.112E-5 1.562E-2
1.623E-1
5.696E-1
 5 79
32 6514 DN Alfaxalone [23930-19-0]; Down 200; 12uM; MCF7; HT HG-U133A Broad Institute CMAP 3.195E-5 1.562E-2
1.623E-1
5.848E-1
 7 195
33 1239 UP LY 294002; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 3.195E-5 1.562E-2
1.623E-1
5.848E-1
 7 195
34 5759 DN Raloxifene hydrochloride [82640-04-8]; Down 200; 7.8uM; PC3; HT HG-U133A Broad Institute CMAP 3.301E-5 1.562E-2
1.623E-1
6.042E-1
 7 196
35 C515055 darinaparsin CTD 3.512E-5 1.562E-2
1.623E-1
6.428E-1
 5 81
36 5434 UP Piribedil hydrochloride [78213-63-5]; Up 200; 12uM; MCF7; HT HG-U133A Broad Institute CMAP 3.522E-5 1.562E-2
1.623E-1
6.447E-1
 7 198
37 5915 DN rotenone; Down 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP 3.522E-5 1.562E-2
1.623E-1
6.447E-1
 7 198
38 D003634 DDT CTD 3.576E-5 1.562E-2
1.623E-1
6.545E-1
 8 272
39 7230 UP Convolamine hydrochloride [500-56-1]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP 3.637E-5 1.562E-2
1.623E-1
6.657E-1
 7 199
40 6822 DN Riboflavine [83-88-5]; Down 200; 10.6uM; MCF7; HT HG-U133A Broad Institute CMAP 3.637E-5 1.562E-2
1.623E-1
6.657E-1
 7 199
41 6410 UP PF-01378883-00 [351320-41-7]; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 3.637E-5 1.562E-2
1.623E-1
6.657E-1
 7 199
42 C059262 cidofovir CTD 3.670E-5 1.562E-2
1.623E-1
6.718E-1
 8 273
43 C030123 coumarin CTD 3.755E-5 1.562E-2
1.623E-1
6.873E-1
 7 200
44 7544 DN CP-944629 [668990-94-1]; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 3.755E-5 1.562E-2
1.623E-1
6.873E-1
 7 200
45 D003035 Cobalt CTD 3.965E-5 1.613E-2
1.676E-1
7.258E-1
 8 276
46 D002997 Clomipramine CTD 4.432E-5 1.763E-2
1.833E-1
8.112E-1
 5 85
47 D005620 Freund's Adjuvant CTD 4.530E-5 1.764E-2
1.833E-1
8.292E-1
 7 206
48 C005274 naringin CTD 4.674E-5 1.782E-2
1.852E-1
8.555E-1
 6 141
49 D001414 Bacitracin CTD 4.849E-5 1.811E-2
1.882E-1
8.875E-1
 4 44
50 D002725 Chloroform CTD 4.956E-5 1.814E-2
1.886E-1
9.072E-1
 5 87
Show 45 more annotations

18: Disease [Display Chart] 2218 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0019202 Hepatolenticular Degeneration DisGeNET Curated 1.243E-5 2.757E-2
2.283E-1
 2.757E-2 5 56
2 umls:C0376634 Craniofacial Abnormalities DisGeNET Curated 6.027E-5 4.560E-2
3.777E-1
1.337E-1
 7 184
3 umls:C0206709 Cystadenoma, Serous DisGeNET BeFree 6.556E-5 4.560E-2
3.777E-1
1.454E-1
 3 15
4 umls:C0001339 Acute pancreatitis DisGeNET BeFree 1.599E-4 4.560E-2
3.777E-1
3.547E-1
 5 95
5 umls:C0027830 neurofibroma DisGeNET Curated 1.618E-4 4.560E-2
3.777E-1
3.590E-1
 4 51
6 umls:C3809874 LEUKEMIA, ACUTE LYMPHOBLASTIC, SUSCEPTIBILITY TO, 3 DisGeNET Curated 1.872E-4 4.560E-2
3.777E-1
4.152E-1
 3 21
7 umls:C0155733 Atherosclerosis of aorta DisGeNET BeFree 2.159E-4 4.560E-2
3.777E-1
4.789E-1
 3 22
8 umls:C0432412 Chromosome 8, trisomy DisGeNET BeFree 2.852E-4 4.560E-2
3.777E-1
6.327E-1
 4 59
9 umls:C0020456 Hyperglycemia DisGeNET Curated 2.989E-4 4.560E-2
3.777E-1
6.629E-1
 9 400
10 umls:C1514422 Primary Glioblastoma DisGeNET BeFree 3.244E-4 4.560E-2
3.777E-1
7.195E-1
 4 61
11 umls:C0013537 Eclampsia DisGeNET BeFree 3.858E-4 4.560E-2
3.777E-1
8.557E-1
 6 177
12 umls:C0730345 Microalbuminuria DisGeNET BeFree 3.901E-4 4.560E-2
3.777E-1
8.653E-1
 4 64
13 umls:C3272363 Ischemic Cerebrovascular Accident DisGeNET Curated 4.707E-4 4.560E-2
3.777E-1
1.000E0
 8 338
14 umls:C0375023 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site DisGeNET BeFree 4.711E-4 4.560E-2
3.777E-1
1.000E0
 7 257
15 umls:C0007133 Carcinoma, Papillary DisGeNET BeFree 5.020E-4 4.560E-2
3.777E-1
1.000E0
 6 186
16 umls:C0796095 Opitz trigonocephaly syndrome DisGeNET Curated 5.920E-4 4.560E-2
3.777E-1
1.000E0
 2 7
17 umls:C0406704 Rudiger syndrome 1 DisGeNET Curated 5.920E-4 4.560E-2
3.777E-1
1.000E0
 2 7
18 umls:C0259783 mixed gliomas DisGeNET BeFree 5.920E-4 4.560E-2
3.777E-1
1.000E0
 2 7
19 umls:C1519670 Tumor Angiogenesis DisGeNET BeFree 6.265E-4 4.560E-2
3.777E-1
1.000E0
 9 443
20 umls:C0035412 Rhabdomyosarcoma DisGeNET Curated 7.121E-4 4.560E-2
3.777E-1
1.000E0
 8 360
21 umls:C0007124 Noninfiltrating Intraductal Carcinoma DisGeNET Curated 7.991E-4 4.560E-2
3.777E-1
1.000E0
 7 281
22 umls:C0948008 Ischemic stroke DisGeNET Curated 8.507E-4 4.560E-2
3.777E-1
1.000E0
 8 370
23 umls:C0206624 Hepatoblastoma DisGeNET Curated 9.473E-4 4.560E-2
3.777E-1
1.000E0
 6 210
24 umls:C1384494 Metastatic Carcinoma DisGeNET BeFree 9.481E-4 4.560E-2
3.777E-1
1.000E0
 3 36
25 umls:C0026470 Monoclonal Gammopathy of Undetermined Significance DisGeNET BeFree 9.834E-4 4.560E-2
3.777E-1
1.000E0
 5 141
26 umls:C0001621 Adrenal Gland Diseases DisGeNET Curated 1.008E-3 4.560E-2
3.777E-1
1.000E0
 2 9
27 umls:C0085220 Cerebral Amyloid Angiopathy DisGeNET Curated 1.028E-3 4.560E-2
3.777E-1
1.000E0
 3 37
28 umls:C0275524 Coinfection DisGeNET BeFree 1.081E-3 4.560E-2
3.777E-1
1.000E0
 5 144
29 umls:C0038358 Gastric ulcer DisGeNET Curated 1.192E-3 4.560E-2
3.777E-1
1.000E0
 4 86
30 umls:C0020480 Hyperlipoproteinemia Type IV DisGeNET Curated 1.255E-3 4.560E-2
3.777E-1
1.000E0
 2 10
31 umls:C1335473 Conventional Chondrosarcoma DisGeNET BeFree 1.255E-3 4.560E-2
3.777E-1
1.000E0
 2 10
32 umls:C3472608 Micropapillary carcinoma DisGeNET BeFree 1.255E-3 4.560E-2
3.777E-1
1.000E0
 2 10
33 umls:C0267111 Gastric dysplasia DisGeNET BeFree 1.255E-3 4.560E-2
3.777E-1
1.000E0
 2 10
34 umls:C0858970 Carcinogenicity DisGeNET BeFree 1.292E-3 4.560E-2
3.777E-1
1.000E0
 3 40
35 umls:C1519689 Tumor Promotion DisGeNET BeFree 1.298E-3 4.560E-2
3.777E-1
1.000E0
 4 88
36 umls:C0936223 Metastatic Prostate Carcinoma DisGeNET BeFree 1.320E-3 4.560E-2
3.777E-1
1.000E0
 6 224
37 umls:C0281361 Adenocarcinoma of pancreas DisGeNET BeFree 1.386E-3 4.560E-2
3.777E-1
1.000E0
 7 309
38 umls:C1336527 Carcinoma of urinary bladder, superficial DisGeNET BeFree 1.388E-3 4.560E-2
3.777E-1
1.000E0
 3 41
39 umls:C0021670 insulinoma DisGeNET Curated 1.415E-3 4.560E-2
3.777E-1
1.000E0
 5 153
40 umls:C0040136 Thyroid Neoplasm DisGeNET Curated 1.465E-3 4.560E-2
3.777E-1
1.000E0
 7 312
41 umls:C1704436 Peripheral Arterial Diseases DisGeNET Curated 1.470E-3 4.560E-2
3.777E-1
1.000E0
 4 91
42 umls:C2936179 Obesity, Visceral DisGeNET BeFree 1.489E-3 4.560E-2
3.777E-1
1.000E0
 3 42
43 umls:C1519666 Tumor-Associated Vasculature DisGeNET BeFree 1.595E-3 4.560E-2
3.777E-1
1.000E0
 3 43
44 umls:C0034069 Pulmonary Fibrosis DisGeNET Curated 1.605E-3 4.560E-2
3.777E-1
1.000E0
 7 317
45 umls:C1292778 Chronic myeloproliferative disorder DisGeNET BeFree 1.676E-3 4.560E-2
3.777E-1
1.000E0
 5 159
46 umls:C0266929 Chronic Periodontitis DisGeNET Curated 1.723E-3 4.560E-2
3.777E-1
1.000E0
 5 160
47 20090112:Kathiresan HDL cholesterol GWAS 1.820E-3 4.560E-2
3.777E-1
1.000E0
 3 45
48 umls:C1861735 Dementia, familial Danish DisGeNET Curated 1.828E-3 4.560E-2
3.777E-1
1.000E0
 2 12
49 umls:C0542519 Congenital absence of kidney DisGeNET BeFree 1.828E-3 4.560E-2
3.777E-1
1.000E0
 2 12
50 umls:C0010635 Cystadenoma, Mucinous DisGeNET BeFree 1.828E-3 4.560E-2
3.777E-1
1.000E0
 2 12
Show 45 more annotations