Toppgene analysis for aggregated_1964_log, IC29, negative side

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1: GO: Molecular Function [Display Chart] 445 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0051087 chaperone binding 7.206E-5 3.207E-2
2.141E-1
 3.207E-2 5 82
2 GO:0061134 peptidase regulator activity 1.765E-4 3.379E-2
2.256E-1
7.855E-2
 7 223
3 GO:0004857 enzyme inhibitor activity 2.278E-4 3.379E-2
2.256E-1
1.014E-1
 9 393
4 GO:0047485 protein N-terminus binding 3.981E-4 4.429E-2
2.957E-1
1.771E-1
 5 118

2: GO: Biological Process [Display Chart] 2518 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0061041 regulation of wound healing 6.040E-7 1.521E-3 1.279E-2 1.521E-3 8 136
2 GO:0007568 aging 5.519E-6 2.544E-3 2.140E-2 1.390E-2 10 310
3 GO:1900047 negative regulation of hemostasis 7.118E-6 2.544E-3 2.140E-2 1.792E-2 5 51
4 GO:0030195 negative regulation of blood coagulation 7.118E-6 2.544E-3 2.140E-2 1.792E-2 5 51
5 GO:0051547 regulation of keratinocyte migration 7.800E-6 2.544E-3 2.140E-2 1.964E-2 3 8
6 GO:0051549 positive regulation of keratinocyte migration 7.800E-6 2.544E-3 2.140E-2 1.964E-2 3 8
7 GO:0050819 negative regulation of coagulation 8.623E-6 2.544E-3 2.140E-2 2.171E-2 5 53
8 GO:1900046 regulation of hemostasis 9.095E-6 2.544E-3 2.140E-2 2.290E-2 6 92
9 GO:0030193 regulation of blood coagulation 9.095E-6 2.544E-3 2.140E-2 2.290E-2 6 92
10 GO:0050818 regulation of coagulation 1.163E-5 2.927E-3 2.461E-2 2.927E-2 6 96
11 GO:0061045 negative regulation of wound healing 2.189E-5 5.010E-3 4.213E-2
5.511E-2
 5 64
12 GO:0010959 regulation of metal ion transport 2.803E-5 5.882E-3 4.946E-2
7.058E-2
 10 374
13 GO:0051546 keratinocyte migration 3.908E-5 6.689E-3
5.625E-2
9.841E-2
 3 13
14 GO:1903034 regulation of response to wounding 4.172E-5 6.689E-3
5.625E-2
1.050E-1
 11 476
15 GO:0051384 response to glucocorticoid 4.205E-5 6.689E-3
5.625E-2
1.059E-1
 7 177
16 GO:0090279 regulation of calcium ion import 4.336E-5 6.689E-3
5.625E-2
1.092E-1
 6 121
17 GO:0070509 calcium ion import 4.516E-5 6.689E-3
5.625E-2
1.137E-1
 7 179
18 GO:0035690 cellular response to drug 5.717E-5 7.997E-3
6.725E-2
1.440E-1
 5 78
19 GO:0031960 response to corticosteroid 6.587E-5 8.729E-3
7.340E-2
1.659E-1
 7 190
20 GO:0000086 G2/M transition of mitotic cell cycle 8.268E-5 1.041E-2
8.753E-2
2.082E-1
 7 197
21 GO:0035967 cellular response to topologically incorrect protein 1.016E-4 1.148E-2
9.650E-2
2.558E-1
 6 141
22 GO:0006979 response to oxidative stress 1.090E-4 1.148E-2
9.650E-2
2.744E-1
 10 440
23 GO:0044839 cell cycle G2/M phase transition 1.093E-4 1.148E-2
9.650E-2
2.752E-1
 7 206
24 GO:0007095 mitotic G2 DNA damage checkpoint 1.094E-4 1.148E-2
9.650E-2
2.754E-1
 3 18
25 GO:0031639 plasminogen activation 1.763E-4 1.775E-2
1.493E-1
4.438E-1
 3 21
26 GO:0097193 intrinsic apoptotic signaling pathway 1.919E-4 1.858E-2
1.562E-1
4.831E-1
 8 301
27 GO:0002011 morphogenesis of an epithelial sheet 2.160E-4 2.015E-2
1.694E-1
5.440E-1
 4 56
28 GO:0042493 response to drug 2.244E-4 2.018E-2
1.697E-1
5.649E-1
 10 481
29 GO:0010757 negative regulation of plasminogen activation 2.721E-4 2.330E-2
1.959E-1
6.852E-1
 2 5
30 GO:1902532 negative regulation of intracellular signal transduction 2.776E-4 2.330E-2
1.959E-1
6.990E-1
 10 494
31 GO:0051701 interaction with host 2.994E-4 2.362E-2
1.986E-1
7.540E-1
 6 172
32 GO:0044818 mitotic G2/M transition checkpoint 3.002E-4 2.362E-2
1.986E-1
7.559E-1
 3 25
33 GO:0052547 regulation of peptidase activity 3.505E-4 2.658E-2
2.235E-1
8.827E-1
 9 416
34 GO:0042730 fibrinolysis 3.788E-4 2.658E-2
2.235E-1
9.539E-1
 3 27
35 GO:0051412 response to corticosterone 3.788E-4 2.658E-2
2.235E-1
9.539E-1
 3 27
36 GO:0001933 negative regulation of protein phosphorylation 4.238E-4 2.658E-2
2.235E-1
1.000E0
 9 427
37 GO:0035966 response to topologically incorrect protein 4.291E-4 2.658E-2
2.235E-1
1.000E0
 6 184
38 GO:0036498 IRE1-mediated unfolded protein response 4.313E-4 2.658E-2
2.235E-1
1.000E0
 4 67
39 GO:0046718 viral entry into host cell 4.336E-4 2.658E-2
2.235E-1
1.000E0
 5 120
40 GO:1903035 negative regulation of response to wounding 4.809E-4 2.658E-2
2.235E-1
1.000E0
 6 188
41 GO:0051828 entry into other organism involved in symbiotic interaction 4.855E-4 2.658E-2
2.235E-1
1.000E0
 5 123
42 GO:0030260 entry into host cell 4.855E-4 2.658E-2
2.235E-1
1.000E0
 5 123
43 GO:0052126 movement in host environment 4.855E-4 2.658E-2
2.235E-1
1.000E0
 5 123
44 GO:0052192 movement in environment of other organism involved in symbiotic interaction 4.855E-4 2.658E-2
2.235E-1
1.000E0
 5 123
45 GO:0044409 entry into host 4.855E-4 2.658E-2
2.235E-1
1.000E0
 5 123
46 GO:0051806 entry into cell of other organism involved in symbiotic interaction 4.855E-4 2.658E-2
2.235E-1
1.000E0
 5 123
47 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 5.199E-4 2.727E-2
2.293E-1
1.000E0
 3 30
48 GO:0046688 response to copper ion 5.199E-4 2.727E-2
2.293E-1
1.000E0
 3 30
49 GO:2001235 positive regulation of apoptotic signaling pathway 5.524E-4 2.754E-2
2.316E-1
1.000E0
 6 193
50 GO:0001558 regulation of cell growth 5.705E-4 2.754E-2
2.316E-1
1.000E0
 9 445
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 220 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005788 endoplasmic reticulum lumen 1.253E-6 2.757E-4 1.647E-3 2.757E-4 9 207
2 GO:0034663 endoplasmic reticulum chaperone complex 2.841E-5 3.125E-3 1.866E-2 6.250E-3 3 12

4: Human Phenotype [Display Chart] 414 annotations before applied cutoff / 4410 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 2053 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008944 decreased sensitivity to induced cell death 6.435E-6 1.321E-2
1.084E-1
 1.321E-2 7 92

6: Domain [Display Chart] 761 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR018181 Heat shock 70 CS InterPro 4.059E-5 1.441E-2
1.039E-1
 3.089E-2 3 13
2 PF00012 HSP70 Pfam 7.856E-5 1.441E-2
1.039E-1
5.979E-2
 3 16
3 PS00297 HSP70 1 PROSITE 9.503E-5 1.441E-2
1.039E-1
7.232E-2
 3 17
4 PS01036 HSP70 3 PROSITE 9.503E-5 1.441E-2
1.039E-1
7.232E-2
 3 17
5 PS00329 HSP70 2 PROSITE 9.503E-5 1.441E-2
1.039E-1
7.232E-2
 3 17
6 IPR013126 Hsp 70 fam InterPro 1.136E-4 1.441E-2
1.039E-1
8.644E-2
 3 18
7 IPR023795 Serpin CS InterPro 6.540E-4 4.305E-2
3.105E-1
4.977E-1
 3 32
8 IPR023796 Serpin dom InterPro 9.270E-4 4.305E-2
3.105E-1
7.055E-1
 3 36
9 PS00284 SERPIN PROSITE 1.005E-3 4.305E-2
3.105E-1
7.648E-1
 3 37
10 SM00093 SERPIN SMART 1.005E-3 4.305E-2
3.105E-1
7.648E-1
 3 37
11 PF00079 Serpin Pfam 1.087E-3 4.305E-2
3.105E-1
8.271E-1
 3 38
12 IPR000215 Serpin fam InterPro 1.173E-3 4.305E-2
3.105E-1
8.926E-1
 3 39
13 2.60.34.10 - Gene3D 1.798E-3 4.305E-2
3.105E-1
1.000E0
 2 12
14 PF00300 His Phos 1 Pfam 1.798E-3 4.305E-2
3.105E-1
1.000E0
 2 12
15 IPR029047 HSP70 peptide-bd InterPro 1.798E-3 4.305E-2
3.105E-1
1.000E0
 2 12
16 IPR013078 His Pase superF clade-1 InterPro 1.798E-3 4.305E-2
3.105E-1
1.000E0
 2 12
17 1.20.1270.10 - Gene3D 2.117E-3 4.305E-2
3.105E-1
1.000E0
 2 13
18 IPR029048 HSP70 C InterPro 2.117E-3 4.305E-2
3.105E-1
1.000E0
 2 13
19 3.40.50.1240 - Gene3D 5.034E-3 4.305E-2
3.105E-1
1.000E0
 2 20
20 IPR029033 His PPase superfam InterPro 5.034E-3 4.305E-2
3.105E-1
1.000E0
 2 20
21 IPR029546 PEA15 InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
22 IPR009976 Sec10-like InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
23 PS51490 KHA PROSITE 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
24 IPR021843 DUF3437 InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
25 IPR003932 EMP 1 InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
26 IPR033681 ELOVL1 InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
27 IPR027673 Exostosin-2 InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
28 SM01348 Nbs1 C SMART 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
29 PS00621 TISSUE FACTOR PROSITE 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
30 PF04573 SPC22 Pfam 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
31 IPR016354 Tissue fac/coagulation fac-3 InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
32 PF09420 Nop16 Pfam 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
33 PS00884 OSTEOPONTIN PROSITE 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
34 PS00706 PRION 2 PROSITE 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
35 PS00291 PRION 1 PROSITE 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
36 IPR030472 Tissue Factor CS InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
37 PD336131 TNFR 12 ProDom 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
38 PF08599 Nbs1 C Pfam 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
39 IPR027653 Formin Diaph1 InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
40 IPR029828 EDIL-3 InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
41 IPR002327 Cyt c 1A/1B InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
42 IPR007653 SPC22 InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
43 IPR033348 AHR InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
44 IPR011268 Purine phosphorylase InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
45 IPR029133 OCC1 InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
46 IPR032430 Blm10 mid InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
47 PF11587 Prion bPrPp Pfam 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
48 SM00017 OSTEO SMART 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
49 IPR019841 Osteopontin CS InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
50 IPR025860 Prion N dom InterPro 5.338E-3 4.305E-2
3.105E-1
1.000E0
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 960 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 106061 Dissolution of Fibrin Clot BioSystems: REACTOME 5.587E-9 5.364E-6 3.993E-5 5.364E-6 5 11
2 P00011 Blood coagulation PantherDB 1.478E-4 4.853E-2
3.613E-1
1.419E-1
 4 40
3 P00050 Plasminogen activating cascade PantherDB 1.899E-4 4.853E-2
3.613E-1
1.823E-1
 3 17
4 106384 Signaling by PDGF BioSystems: REACTOME 2.022E-4 4.853E-2
3.613E-1
1.941E-1
 7 179

8: Pubmed [Display Chart] 21975 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20628624 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". Pubmed 1.786E-9 1.912E-5 2.022E-4 3.924E-5 8 172
2 20628624:gr Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". GeneRIF 1.786E-9 1.912E-5 2.022E-4 3.924E-5 8 172
3 18029284:gr Plasminogen activator and plasma activator inhibitor-1 in young women with polycystic ovary syndrome. GeneRIF 6.959E-9 1.912E-5 2.022E-4 1.529E-4 3 3
4 19290852 Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts. Pubmed 6.959E-9 1.912E-5 2.022E-4 1.529E-4 3 3
5 11816707 Imbalance of plasminogen activator inhibitor-I/ tissue plasminogen activator and tissue factor/tissue factor pathway inhibitor in young Japanese men with myocardial infarction. Pubmed 6.959E-9 1.912E-5 2.022E-4 1.529E-4 3 3
6 18029284 Plasminogen activator and plasma activator inhibitor-1 in young women with polycystic ovary syndrome. Pubmed 6.959E-9 1.912E-5 2.022E-4 1.529E-4 3 3
7 19290852:gr Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts. GeneRIF 6.959E-9 1.912E-5 2.022E-4 1.529E-4 3 3
8 11816707:gr Imbalance of plasminogen activator inhibitor-I/ tissue plasminogen activator and tissue factor/tissue factor pathway inhibitor in young Japanese men with myocardial infarction. GeneRIF 6.959E-9 1.912E-5 2.022E-4 1.529E-4 3 3
9 19088796 Effect of oxidative stress on the expression of t-PA, u-PA, u-PAR, and PAI-1 in endothelial cells. Pubmed 2.780E-8 4.363E-5 4.614E-4 6.109E-4 3 4
10 20447686 Genetic polymorphisms in the fibrinolytic system of placentas with massive perivillous fibrin deposition. Pubmed 2.780E-8 4.363E-5 4.614E-4 6.109E-4 3 4
11 20447686:gr Genetic polymorphisms in the fibrinolytic system of placentas with massive perivillous fibrin deposition. GeneRIF 2.780E-8 4.363E-5 4.614E-4 6.109E-4 3 4
12 20810696:gr TWEAK-Fn14 interaction enhances plasminogen activator inhibitor 1 and tissue factor expression in atherosclerotic plaques and in cultured vascular smooth muscle cells. GeneRIF 2.780E-8 4.363E-5 4.614E-4 6.109E-4 3 4
13 19088796:gr Effect of oxidative stress on the expression of t-PA, u-PA, u-PAR, and PAI-1 in endothelial cells. GeneRIF 2.780E-8 4.363E-5 4.614E-4 6.109E-4 3 4
14 26548921 Distinct encounter complexes of PAI-1 with plasminogen activators and vitronectin revealed by changes in the conformation and dynamics of the reactive center loop. Pubmed 2.780E-8 4.363E-5 4.614E-4 6.109E-4 3 4
15 22623428 Proteomic analysis of ¿4�1 integrin adhesion complexes reveals ¿-subunit-dependent protein recruitment. Pubmed 4.280E-8 6.270E-5 6.631E-4 9.405E-4 10 491
16 24769233 Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. Pubmed 4.768E-8 6.549E-5 6.925E-4 1.048E-3 5 50
17 19176991:gr The plasminogen activator system and cancer. GeneRIF 6.940E-8 8.472E-5 8.959E-4 1.525E-3 3 5
18 19176991 The plasminogen activator system and cancer. Pubmed 6.940E-8 8.472E-5 8.959E-4 1.525E-3 3 5
19 19199708 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Pubmed 1.212E-7 1.269E-4 1.342E-3 2.663E-3 9 414
20 17934860 Mcp-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes in hepatopulmonary syndrome. Pubmed 1.386E-7 1.269E-4 1.342E-3 3.046E-3 3 6
21 17934860:gr Mcp-1, eNOS, tPA and PAI-1 gene polymorphism and correlation of genotypes and phenotypes in hepatopulmonary syndrome. GeneRIF 1.386E-7 1.269E-4 1.342E-3 3.046E-3 3 6
22 19356953 Elevated tissue expression of thrombomodulatory factors correlates with acute symptomatic carotid plaque phenotype. Pubmed 1.386E-7 1.269E-4 1.342E-3 3.046E-3 3 6
23 11384978 The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. Pubmed 1.386E-7 1.269E-4 1.342E-3 3.046E-3 3 6
24 19356953:gr Elevated tissue expression of thrombomodulatory factors correlates with acute symptomatic carotid plaque phenotype. GeneRIF 1.386E-7 1.269E-4 1.342E-3 3.046E-3 3 6
25 22190034 Global landscape of HIV-human protein complexes. Pubmed 2.778E-7 2.442E-4 2.582E-3 6.105E-3 9 457
26 20810696 TWEAK-Fn14 interaction enhances plasminogen activator inhibitor 1 and tissue factor expression in atherosclerotic plaques and in cultured vascular smooth muscle cells. Pubmed 3.870E-7 3.271E-4 3.459E-3 8.504E-3 3 8
27 20140262 Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. Pubmed 4.852E-7 3.808E-4 4.027E-3 1.066E-2 5 79
28 20140262:gr Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. GeneRIF 4.852E-7 3.808E-4 4.027E-3 1.066E-2 5 79
29 19085655 Genetic architecture of tissue-type plasminogen activator and plasminogen activator inhibitor-1. Pubmed 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
30 18922856:gr Unique secretory dynamics of tissue plasminogen activator and its modulation by plasminogen activator inhibitor-1 in vascular endothelial cells. GeneRIF 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
31 20335166 The Salmonella type III secretion effector, salmonella leucine-rich repeat protein (SlrP), targets the human chaperone ERdj3. Pubmed 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
32 23994556 The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A. Pubmed 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
33 18199802:gr Protease nexin-1, tPA, and PAI-1 are upregulated in cryoglobulinemic membranoproliferative glomerulonephritis. GeneRIF 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
34 20500107:gr Tissue plasminogen activator and plasminogen activator inhibitor 1 in obese and lean patients with polycystic ovary syndrome. GeneRIF 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
35 12719777:gr Stimulation of plasminogen activation by recombinant cellular prion protein is conserved in the NH2-terminal fragment PrP23-110. GeneRIF 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
36 23619422 Osteopontin-mediated myocardial fibrosis in heart failure: a role for lysyl oxidase? Pubmed 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
37 22771216 Association of tissue plasminogen activator and plasminogen activator inhibitor polymorphism with myocardial infarction: a meta-analysis. Pubmed 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
38 12524082 Modulation of the expression of tissue plasminogen activator and its inhibitor by hypoxia in human peritoneal and adhesion fibroblasts. Pubmed 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
39 21414238:gr Association of plasminogen activator inhibitor-1 and tissue plasminogen activator with type 2 diabetes and metabolic syndrome in Malaysian subjects. GeneRIF 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
40 18922856 Unique secretory dynamics of tissue plasminogen activator and its modulation by plasminogen activator inhibitor-1 in vascular endothelial cells. Pubmed 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
41 21158116:gr [Homocysteine' s effect on tPA and PAI-1 gene expression in HUVEC]. GeneRIF 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
42 24999729 Urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1) are potential predictive biomarkers in early stage oral squamous cell carcinomas (OSCC). Pubmed 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
43 16055744:gr Binding of calmodulin to the carboxy-terminal region of p21 induces nuclear accumulation via inhibition of protein kinase C-mediated phosphorylation of Ser153. GeneRIF 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
44 12719777 Stimulation of plasminogen activation by recombinant cellular prion protein is conserved in the NH2-terminal fragment PrP23-110. Pubmed 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
45 21217698 Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions. Pubmed 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
46 21501649 Antithrombotic and profibrinolytic activities of phloroglucinol. Pubmed 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
47 2503541 Interaction between plasminogen activator inhibitor type 1 (PAI-1) bound to fibrin and either tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). Binding of t-PA/PAI-1 complexes to fibrin mediated by both the finger and the kringle-2 domain of t-PA. Pubmed 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
48 19492158 Role of viral receptors TLR3, RIG-I and MDA5 in mesothelial tissue-type plasminogen activator and plasminogen activator inhibitor-1 synthesis. Pubmed 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
49 14983221:gr Both lysine-clusters of the NH2-terminal prion-protein fragment PrP23-110 are essential for t-PA mediated plasminogen activation. GeneRIF 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
50 16015279:gr Brain endothelial hemostasis regulation by pericytes. GeneRIF 3.682E-6 5.057E-4 5.348E-3
8.091E-2
 2 2
Show 45 more annotations

9: Interaction [Display Chart] 3103 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:TCTN1 TCTN1 interactions 2.295E-7 7.121E-4 6.136E-3 7.121E-4 8 107
2 int:PLAU PLAU interactions 9.924E-7 1.540E-3 1.327E-2 3.080E-3 5 31
3 int:HYOU1 HYOU1 interactions 4.971E-6 4.630E-3 3.990E-2 1.543E-2 6 74
4 int:F2 F2 interactions 5.968E-6 4.630E-3 3.990E-2 1.852E-2 5 44
5 int:LRP1 LRP1 interactions 9.046E-6 5.614E-3 4.838E-2 2.807E-2 6 82
6 int:TCTN3 TCTN3 interactions 1.836E-5 9.495E-3
8.182E-2
5.697E-2
 10 317
7 int:KRT8 KRT8 interactions 4.114E-5 1.824E-2
1.572E-1
1.277E-1
 5 65
8 int:DNAJA4 DNAJA4 interactions 1.093E-4 4.239E-2
3.653E-1
3.391E-1
 4 42
9 int:CLEC3B CLEC3B interactions 1.293E-4 4.457E-2
3.841E-1
4.011E-1
 3 17
10 int:CBL CBL interactions 1.440E-4 4.468E-2
3.850E-1
4.468E-1
 8 257
11 int:BAG6 BAG6 interactions 1.731E-4 4.699E-2
4.049E-1
5.371E-1
 8 264
12 int:F10 F10 interactions 1.826E-4 4.699E-2
4.049E-1
5.667E-1
 3 19
13 int:MOG MOG interactions 2.070E-4 4.699E-2
4.049E-1
6.424E-1
 2 4
14 int:LRP1B LRP1B interactions 2.139E-4 4.699E-2
4.049E-1
6.639E-1
 3 20
15 int:DCTN2 DCTN2 interactions 2.272E-4 4.699E-2
4.049E-1
7.049E-1
 5 93
Show 10 more annotations

10: Cytoband [Display Chart] 93 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 5q14 5q14 3.509E-4 3.263E-2
1.669E-1
 3.263E-2 2 10

11: Transcription Factor Binding Site [Display Chart] 448 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 68 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 583 Heat shock 70kDa proteins genenames.org 2.725E-5 1.853E-3 8.903E-3 1.853E-3 3 17
2 471 CD molecules|V-set domain containing|Immunoglobulin like domain containing|Carcinoembryonic antigen related cell adhesion molecule family genenames.org 6.912E-5 2.350E-3 1.129E-2 4.700E-3 8 394
3 739 Serpin peptidase inhibitors genenames.org 2.962E-4 6.713E-3 3.225E-2 2.014E-2 3 37

13: Coexpression [Display Chart] 5821 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M14072 Genes regulated by hypoxia, based on literature searches. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.369E-16 5.093E-12 4.710E-11 5.454E-12 17 242
2 M19541 Genes commonly down-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.249E-15 5.093E-12 4.710E-11 1.309E-11 20 408
3 M9128 Genes up-regulated in UB27 cells (osteosarcoma) at any time point after inducing the expression of a mutant form of WT1 [GeneID=7490]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.625E-15 5.093E-12 4.710E-11 1.528E-11 16 214
4 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.175E-14 3.166E-11 2.927E-10 1.266E-10 20 460
5 M5890 Genes regulated by NF-kB in response to TNF [GeneID=7124]. MSigDB H: Hallmark Gene Sets (v5.1) 4.021E-13 4.681E-10 4.328E-9 2.340E-9 14 200
6 M18938 Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of both HDAC1 and HDAC2 [GeneID=3065;3066] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.304E-12 4.175E-9 3.861E-8 2.505E-8 14 238
7 M5850 Genes up-regulated in comparison of monocytes treated with anti-TREM1 [GeneID=54210] versus monocytes treated with control IgG. MSigDB C7: Immunologic Signatures (v5.1) 7.040E-12 5.854E-9 5.413E-8 4.098E-8 13 199
8 M16010 Genes down-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.815E-12 6.414E-9 5.931E-8 5.131E-8 14 251
9 M2656 Genes up-regulated in early serum response of CRL 2091 cells (foreskin fibroblasts). MSigDB C6: Oncogenic Signatures (v5.1) 1.254E-11 8.108E-9 7.497E-8 7.297E-8 12 164
10 M5852 Genes up-regulated in comparison of monocytes treated with anti-TREM1 [GeneID=54210] versus monocytes treated wth vehicle. MSigDB C7: Immunologic Signatures (v5.1) 1.012E-10 5.726E-8 5.295E-7 5.888E-7 12 196
11 M2445 Genes up-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 10 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.207E-10 5.726E-8 5.295E-7 7.024E-7 12 199
12 M5891 Genes up-regulated in response to low oxygen levels (hypoxia). MSigDB H: Hallmark Gene Sets (v5.1) 1.279E-10 5.726E-8 5.295E-7 7.444E-7 12 200
13 M5932 Genes defining inflammatory response. MSigDB H: Hallmark Gene Sets (v5.1) 1.279E-10 5.726E-8 5.295E-7 7.444E-7 12 200
14 M2293 Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.804E-10 7.500E-8 6.935E-7 1.050E-6 14 315
15 M12527 Down-regulated genes that vary between HNSCC (head and neck squamous cell carcinoma) groups formed on the basis of their level of pathological differentiation: well vs poorly differentiated tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.156E-10 8.368E-8 7.737E-7 1.255E-6 15 382
16 M14507 Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.498E-10 8.590E-8 7.943E-7 1.454E-6 16 454
17 M5042 Up-regulated genes in the canonical gene expression signature of the fibroblast core serum response (CSR) defined by the Stanford group. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.509E-10 8.590E-8 7.943E-7 1.460E-6 12 212
18 M13936 Genes down-regulated in BJAB cells (B-lymphoma) after glutamine [PubChem=738] deprivation. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.362E-10 1.411E-7 1.304E-6 2.539E-6 14 337
19 M4288 Genes up-regulated in MCF10A cells (breast cancer) grown at low (mesenchymal phenotype) compared to those grown at high (epithelial, basal-like phenotype) confluency. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.492E-10 1.989E-7 1.839E-6 3.779E-6 11 180
20 M19097 Genes up-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.794E-10 2.266E-7 2.095E-6 4.537E-6 16 491
21 M2352 Transcripts (mRNA molecules) rapidly degraded upon interaction with KHSRP [GeneID=8570]. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.176E-10 2.266E-7 2.095E-6 4.759E-6 9 100
22 M2784 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of PCGF2 [Gene ID=7703] gene by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 9.510E-10 2.464E-7 2.279E-6 5.536E-6 10 141
23 M12104 Genes down-regulated in BJAB cells (B-lymphoma) after leucine [PubChem=857] deprivation. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.736E-10 2.464E-7 2.279E-6 5.668E-6 11 187
24 M2779 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 and PCGF2 [Gene ID=648, 7703] genes by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 1.251E-9 3.033E-7 2.805E-6 7.280E-6 10 145
25 M5953 Genes up-regulated by KRAS activation. MSigDB H: Hallmark Gene Sets (v5.1) 1.981E-9 3.604E-7 3.332E-6 1.153E-5 11 200
26 M4459 Genes down-regulated in comparison of monocytes cultured for 0 days versus those cultured for 1 day. MSigDB C7: Immunologic Signatures (v5.1) 1.981E-9 3.604E-7 3.332E-6 1.153E-5 11 200
27 M5921 Genes encoding components of the complement system, which is part of the innate immune system. MSigDB H: Hallmark Gene Sets (v5.1) 1.981E-9 3.604E-7 3.332E-6 1.153E-5 11 200
28 M4386 Genes down-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from TLR4 [GeneID=7099] deficient mice subjected to ozone for 48 h. MSigDB C7: Immunologic Signatures (v5.1) 1.981E-9 3.604E-7 3.332E-6 1.153E-5 11 200
29 GSE22196 HEALTHY VS OBESE MOUSE SKIN GAMMADELTA TCELL DN Genes down-regulated in skin gamma delta T cells: healthy versus obesity. MSigDB C7: Immunologic Signatures (v5.1) 1.981E-9 3.604E-7 3.332E-6 1.153E-5 11 200
30 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v5.1) 1.981E-9 3.604E-7 3.332E-6 1.153E-5 11 200
31 M5924 Genes up-regulated through activation of mTORC1 complex. MSigDB H: Hallmark Gene Sets (v5.1) 1.981E-9 3.604E-7 3.332E-6 1.153E-5 11 200
32 GSE43955 10H VS 60H ACT CD4 TCELL WITH TGFB IL6 DN Genes down-regulated in CD4 [GeneID=920] T helper cells Th17 treated with TGFB1 and IL6 [GeneID=7040;3569]: 10h versus 60h. MSigDB C7: Immunologic Signatures (v5.1) 1.981E-9 3.604E-7 3.332E-6 1.153E-5 11 200
33 M14973 Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC1 [GeneID=3065] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.519E-9 4.443E-7 4.109E-6 1.466E-5 15 457
34 M12029 Genes selected in supervised analyses to discriminate cells expressing activated HRAS [GeneID=3265] oncogene from control cells expressing GFP. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.690E-9 4.606E-7 4.259E-6 1.566E-5 12 261
35 M8857 Genes up-regulated in UB27 cells (osteosarcoma) at 8 hr after inducing the expression of a mutant form of WT1 [GeneID=7490]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.142E-9 6.697E-7 6.193E-6 2.411E-5 10 164
36 M8729 Genes whose expression peaked at 480 min after stimulation of HeLa cells with EGF [GeneID=1950]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.142E-9 6.697E-7 6.193E-6 2.411E-5 10 164
37 M1435 Genes up-regulated in macrophages by aerolysin-related cytotoxic enterotoxin (Act) from Aeromonas hydrophila. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.182E-9 8.077E-7 7.469E-6 3.017E-5 8 85
38 M12676 Class NT (non-tolerizeable) genes: induced during the first LPS stimulation and induced at equal or greater degree in tolerant macrophages. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.273E-9 8.077E-7 7.469E-6 3.069E-5 14 409
39 M2882 Genes up-regulated in four lineages of epithelial cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v5.1) 5.926E-9 8.845E-7 8.179E-6 3.450E-5 12 280
40 M1448 Genes up-regulated in RAW 264.7 cells (macrophage) 3 hr after stimulation with bacterial lipopolysaccharide (LPS). MSigDB C2: CGP Curated Gene Sets (v5.1) 6.845E-9 9.961E-7 9.210E-6 3.984E-5 8 88
41 M11585 Genes up-regulated in MCF7 cells (breast cancer) after stimulation with NRG1 [GeneID=3084]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.744E-9 1.099E-6 1.017E-5 4.508E-5 10 175
42 M2123 Up-regulated genes in the cancer gene signature, representing a gene signature of cellular transformation. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.447E-8 2.006E-6 1.855E-5 8.425E-5 11 242
43 M19048 Genes down-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.833E-8 2.482E-6 2.295E-5 1.067E-4 9 142
44 M2634 Genes up-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] and engineered to express ligand-activatable EGFR [Gene ID=1956]. MSigDB C6: Oncogenic Signatures (v5.1) 1.975E-8 2.613E-6 2.416E-5 1.150E-4 10 193
45 M19360 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 11. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.393E-8 3.096E-6 2.863E-5 1.393E-4 8 103
46 M6189 Genes down-regulated in MCF7 cells (breast cancer) after knockdown of both HIF1A and HIF2A [GeneID=3091;2034] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.583E-8 3.162E-6 2.924E-5 1.504E-4 8 104
47 GSE41176 UNSTIM VS ANTI IGM STIM BCELL 3H UP Genes up-regulated in B lymphocytes: untreated versus anti-IgM for 3h. MSigDB C7: Immunologic Signatures (v5.1) 2.642E-8 3.162E-6 2.924E-5 1.538E-4 10 199
48 GSE19923 E2A KO VS HEB AND E2A KO DP THYMOCYTE UP Genes up-regulated in double positive thymocytes: TCF3 [GeneID=6929] knockout versus TCF12 [GeneID=6938] knockout. MSigDB C7: Immunologic Signatures (v5.1) 2.771E-8 3.162E-6 2.924E-5 1.613E-4 10 200
49 GSE22140 HEALTHY VS ARTHRITIC GERMFREE MOUSE CD4 TCELL DN Genes down-regulated in CD4 [GeneID=920] T cells under germ free conditions: healthy versus arthritis (KRN model). MSigDB C7: Immunologic Signatures (v5.1) 2.771E-8 3.162E-6 2.924E-5 1.613E-4 10 200
50 M5787 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with type 1 diabetes at the time of the diagnosis versus those at 4 months later. MSigDB C7: Immunologic Signatures (v5.1) 2.771E-8 3.162E-6 2.924E-5 1.613E-4 10 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2383 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM538280 500 Myeloid Cells, DC.LC.Sk, MHCII+ CD11b+ CD45+, Skin, avg-2 Immgen.org, GSE15907 4.343E-12 1.035E-8 8.646E-8 1.035E-8 18 452
2 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 2.695E-10 3.211E-7 2.682E-6 6.422E-7 16 438
3 26Dn SubClass 26Dn 2 Top 500 All 26Dn SubClass 26Dn 2 Top 500 All Brain Map - Allen iN 1.728E-9 1.372E-6 1.146E-5 4.117E-6 16 498
4 Lungmap Mouse e16.5 Endothelial Top 500 All Mouse Lung E16.5 Endothelial top 500 Lungmap Mouse Single Cell (Lungmap.net) 3.161E-9 1.883E-6 1.573E-5 7.533E-6 15 446
5 GSM777037 500 Stromal Cells, BEC.SLN, gp38- CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 3.769E-8 1.796E-5 1.500E-4 8.981E-5 14 459
6 80Dn SubClass 80Dn 1 Top 500 All 80Dn SubClass 80Dn 1 Top 500 All Brain Map - Allen iN 8.241E-8 2.561E-5 2.139E-4 1.964E-4 14 489
7 80Dn SubClass 80Dn 1 Top 500 Cluster 0 80Dn SubClass 80Dn 1 Top 500 Cluster 0 Brain Map - Allen iN 8.241E-8 2.561E-5 2.139E-4 1.964E-4 14 489
8 gudmap dev gonad e12.5 M gudmap devVasTestis Flk 500 dev gonad e12.5 M DevVasTestis Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.598E-8 2.561E-5 2.139E-4 2.049E-4 13 414
9 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 9.811E-8 2.598E-5 2.170E-4 2.338E-4 14 496
10 gudmap kidney adult GlomCapSys Tie2 500 kidney adult GlomCapSys Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.229E-7 2.928E-5 2.446E-4 2.928E-4 13 427
11 gudmap developingLowerUrinaryTract P1 bladder B 1000 k2 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.563E-7 5.553E-5 4.638E-4 6.108E-4 12 379
12 gudmap dev gonad e11.5 F ReproVasc Flk 500 dev gonad e11.5 F ReproVasc Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 5.761E-7 1.026E-4 8.573E-4 1.373E-3 12 409
13 gudmap kidney e15.5 SmlBldVes Tie2 500 kidney e15.5 SmlBldVes Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.384E-7 1.026E-4 8.573E-4 1.521E-3 12 413
14 OPC Top 500 All OPC Top 500 All Brain Map - Barres 6.454E-7 1.026E-4 8.573E-4 1.538E-3 13 494
15 gudmap dev gonad e12.5 F gudmap devVasOvary Flk 500 dev gonad e12.5 F DevVasOvary Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.718E-7 1.026E-4 8.573E-4 1.601E-3 12 415
16 gudmap dev gonad e13.5 F gudmap devVascOvary Flk 500 dev gonad e13.5 F DevVascOvary Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.890E-7 1.026E-4 8.573E-4 1.642E-3 12 416
17 gudmap kidney adult RenCorpuscGlomer 500 kidney adult RenCorpuscGlomer top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.183E-6 1.626E-4 1.358E-3 2.819E-3 12 438
18 gudmap dev gonad e12.5 M SertoliCell Sox9 k1 1000 dev gonad e12.5 M SertoliCell Sox9 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.228E-6 1.626E-4 1.358E-3 2.927E-3 7 114
19 gudmap dev gonad e11.5 F ReproVasc Flk k3 1000 dev gonad e11.5 F ReproVasc Flk k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.363E-6 1.710E-4 1.428E-3 3.249E-3 12 444
20 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 1.679E-6 2.001E-4 1.672E-3 4.002E-3 12 453
21 GSM777032 500 Stromal Cells, BEC.MLN, gp38- CD31+, Lymph Node, avg-5 Immgen.org, GSE15907 1.798E-6 2.041E-4 1.705E-3 4.286E-3 12 456
22 gudmap developingLowerUrinaryTract e14.5 bladder 1000 k5 DevelopingLowerUrinaryTract e14.5 bladder emap-30872 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.050E-6 3.304E-4 2.760E-3 7.268E-3 11 397
23 Lungmap Mouse e18.5 Epithelial (GSE52583) Top 500 Cluster 2 Mouse Lung E18.5 Epithelial top 500 c2 Lungmap Mouse Single Cell (Lungmap.net) 3.280E-6 3.399E-4 2.839E-3 7.817E-3 7 132
24 gudmap kidney e15.5 SmlBldVes Tie2 k4 500 kidney e15.5 SmlBldVes Tie2 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.576E-6 3.550E-4 2.966E-3 8.521E-3 8 190
25 microglia Top 500 All microglia Top 500 All Brain Map - Barres 3.849E-6 3.669E-4 3.065E-3 9.172E-3 12 491
26 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 4.096E-6 3.754E-4 3.136E-3 9.761E-3 12 494
27 GSM854271 500 Myeloid Cells, DC.103-11b+24-.Lu, MHCII+ CD11c+ CD103- CD11b+ CD24-, Lung, avg-2 Immgen.org, GSE15907 4.552E-6 4.017E-4 3.356E-3 1.085E-2 11 414
28 GSM538282 500 Myeloid Cells, MF.Lu, CD11chi CD11b- CD103- MHCII- SiglecF+, Lung, avg-3 Immgen.org, GSE15907 5.838E-6 4.968E-4 4.150E-3 1.391E-2 11 425
29 gudmap kidney adult GlomCapSys Tie2 k2 500 kidney adult GlomCapSys Tie2 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.307E-6 6.004E-4 5.016E-3 1.741E-2 7 149
30 gudmap dev gonad e13.5 M gudmap devVasTestis Flk k4 500 dev gonad e13.5 M DevVasTestis Flk k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.260E-6 6.561E-4 5.481E-3 1.968E-2 9 282
31 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 1.109E-5 8.522E-4 7.119E-3 2.642E-2 11 455
32 gudmap dev gonad e12.5 M gudmap devVasTestis Flk k2 500 dev gonad e12.5 M DevVasTestis Flk k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.284E-5 9.561E-4 7.987E-3 3.059E-2 9 298
33 gudmap developingLowerUrinaryTract e14.5 bladder 500 k1 DevelopingLowerUrinaryTract e14.5 bladder emap-30872 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.494E-5 1.078E-3 9.004E-3 3.561E-2 8 231
34 gudmap developingLowerUrinaryTract P1 bladder B 500 k1 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.538E-5 1.078E-3 9.004E-3 3.665E-2 7 167
35 gudmap RNAseq p2 Glomerlular Endothelial 2500 K4 gudmap RNAseq p2 Glomerlular Endothelial 2500 K4 Gudmap RNAseq 1.800E-5 1.170E-3 9.773E-3 4.290E-2 10 392
36 gudmap developingKidney e15.5 Ureteral Smooth Musc 500 DevelopingKidney e15.5 Ureteral Smooth Musc emap-28812 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.840E-5 1.170E-3 9.773E-3 4.384E-2 10 393
37 gudmap kidney adult GlomCapSys Tie2 200 kidney adult GlomCapSys Tie2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.932E-5 1.170E-3 9.773E-3 4.605E-2 7 173
38 Lungmap Mouse e16.5 Endothelial Top 500 Cluster 2 Mouse Lung E16.5 Endothelial top 500 c2 Lungmap Mouse Single Cell (Lungmap.net) 1.962E-5 1.170E-3 9.773E-3 4.675E-2 6 116
39 gudmap kidney adult RenCorpuscGlomer k2 500 kidney adult RenCorpuscGlomer k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.962E-5 1.170E-3 9.773E-3 4.675E-2 6 116
40 Lungmap Mouse e18.5 Epithelial (GSE52583) Top 500 All Mouse Lung E18.5 Epithelial top 500 Lungmap Mouse Single Cell (Lungmap.net) 1.964E-5 1.170E-3 9.773E-3 4.680E-2 10 396
41 Facebase RNAseq e9.5 Facial Mesenchyne 500 FacebaseRNAseq e9.5 Facial Mesenchyne top-relative-expression-ranked 500 FaceBase_RNAseq 2.043E-5 1.187E-3 9.919E-3 4.868E-2 11 486
42 PCBC ctl CardiacMyocyte 500 Progenitor-Cell-Biology-Consortium reference CardiacMyocyte top-relative-expression-ranked 500 PCBC 2.418E-5 1.372E-3 1.146E-2
5.763E-2
 11 495
43 gudmap dev gonad e12.5 F gudmap devVasOvary Flk k1 1000 dev gonad e12.5 F DevVasOvary Flk k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.185E-5 1.751E-3 1.463E-2
7.591E-2
 7 187
44 ratio EB vs SC 1000 K1 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 3.304E-5 1.751E-3 1.463E-2
7.875E-2
 9 336
45 gudmap developingLowerUrinaryTract e14.5 bladder 500 DevelopingLowerUrinaryTract e14.5 bladder emap-30872 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.306E-5 1.751E-3 1.463E-2
7.879E-2
 10 421
46 endothelial Top 500 Cluster 0 endothelial Top 500 Cluster 0 Brain Map - Barres 3.425E-5 1.774E-3 1.482E-2
8.162E-2
 6 128
47 Lungmap Mouse e16.5 Epithelial SubClass Proliferative AT2 Progenitor Top 500 Cluster 1 Mouse Lung E16.5 Epithelial Proliferative AT2 Progenitor c1 Lungmap Mouse Single Cell (Lungmap.net) 3.769E-5 1.884E-3 1.574E-2
8.983E-2
 7 192
48 gudmap kidney adult Mesangium Meis 500 kidney adult Mesangium Meis top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.876E-5 1.884E-3 1.574E-2
9.236E-2
 10 429
49 gudmap dev gonad e12.5 M SertoliCell Sox9 k2 500 dev gonad e12.5 M SertoliCell Sox9 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.897E-5 1.884E-3 1.574E-2
9.286E-2
 4 40
50 gudmap dev gonad e13.5 M gudmap devVasTestis Flk 500 dev gonad e13.5 M DevVasTestis Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.953E-5 1.884E-3 1.574E-2
9.419E-2
 10 430
Show 45 more annotations

15: Computational [Display Chart] 388 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 3 Genes in module 3 MSigDb: C4 - CM: Cancer Modules 1.232E-12 4.780E-10 3.126E-9 4.780E-10 21 375
2 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 4.850E-9 9.409E-7 6.153E-6 1.882E-6 18 419
3 module 321 Genes in module 321 MSigDb: C4 - CM: Cancer Modules 2.100E-7 2.716E-5 1.776E-4 8.148E-5 9 108
4 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 5.602E-7 5.434E-5 3.554E-4 2.174E-4 15 395
5 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 1.898E-6 1.473E-4 9.632E-4 7.364E-4 14 378
6 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 7.039E-6 4.552E-4 2.977E-3 2.731E-3 14 423
7 module 18 Genes in module 18 MSigDb: C4 - CM: Cancer Modules 9.952E-6 5.516E-4 3.607E-3 3.862E-3 14 436
8 module 399 Genes in module 399 MSigDb: C4 - CM: Cancer Modules 5.142E-5 2.494E-3 1.631E-2 1.995E-2 5 50
9 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 1.233E-4 5.019E-3 3.282E-2 4.783E-2 11 351
10 module 164 Genes in module 164 MSigDb: C4 - CM: Cancer Modules 1.346E-4 5.019E-3 3.282E-2
5.222E-2
 5 61
11 module 131 Genes in module 131 MSigDb: C4 - CM: Cancer Modules 1.423E-4 5.019E-3 3.282E-2
5.520E-2
 4 33
12 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 1.579E-4 5.107E-3 3.340E-2
6.128E-2
 11 361
13 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 3.683E-4 1.099E-2
7.188E-2
1.429E-1
 8 216
14 module 8 Genes in module 8 MSigDb: C4 - CM: Cancer Modules 4.353E-4 1.130E-2
7.392E-2
1.689E-1
 11 406
15 module 191 Genes in module 191 MSigDb: C4 - CM: Cancer Modules 4.661E-4 1.130E-2
7.392E-2
1.809E-1
 3 19
16 module 262 Genes in module 262 MSigDb: C4 - CM: Cancer Modules 4.661E-4 1.130E-2
7.392E-2
1.809E-1
 3 19
Show 11 more annotations

16: MicroRNA [Display Chart] 1219 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 miR-199a-star:PicTar miR-199a-star:PicTar PicTar 1.421E-6 1.053E-3 8.090E-3 1.732E-3 12 422
2 miR-101:PicTar miR-101:PicTar PicTar 1.727E-6 1.053E-3 8.090E-3 2.106E-3 12 430
3 hsa-miR-101:PITA hsa-miR-101:PITA TOP PITA 5.232E-6 2.126E-3 1.633E-2 6.378E-3 12 479
4 miR-144:PicTar miR-144:PicTar PicTar 1.165E-5 2.290E-3 1.759E-2 1.420E-2 11 433
5 hsa-miR-802:PITA hsa-miR-802:PITA TOP PITA 1.737E-5 2.290E-3 1.759E-2 2.117E-2 11 452
6 hsa-let-7a:miRTarbase hsa-let-7a:miRTarbase miRTarbase 2.220E-5 2.290E-3 1.759E-2 2.707E-2 4 33
7 miR-142-5p:PicTar miR-142-5p:PicTar PicTar 2.569E-5 2.290E-3 1.759E-2 3.132E-2 9 308
8 hsa-miR-29b:miRecords TarBase hsa-miR-29b:miRecords TarBase miRecords_TarBase 2.643E-5 2.290E-3 1.759E-2 3.222E-2 3 12
9 hsa-miR-34c-3p:PITA hsa-miR-34c-3p:PITA TOP PITA 2.661E-5 2.290E-3 1.759E-2 3.244E-2 8 237
10 TGGTGCT,MIR-29B:MSigDB TGGTGCT,MIR-29B:MSigDB MSigDB 3.017E-5 2.290E-3 1.759E-2 3.677E-2 11 480
11 TGGTGCT,MIR-29A:MSigDB TGGTGCT,MIR-29A:MSigDB MSigDB 3.017E-5 2.290E-3 1.759E-2 3.677E-2 11 480
12 TGGTGCT,MIR-29C:MSigDB TGGTGCT,MIR-29C:MSigDB MSigDB 3.017E-5 2.290E-3 1.759E-2 3.677E-2 11 480
13 GTACTGT,MIR-101:MSigDB GTACTGT,MIR-101:MSigDB MSigDB 3.088E-5 2.290E-3 1.759E-2 3.764E-2 8 242
14 hsa-miR-371-5p:PITA hsa-miR-371-5p:PITA TOP PITA 3.180E-5 2.290E-3 1.759E-2 3.877E-2 8 243
15 hsa-miR-148a:PITA hsa-miR-148a:PITA TOP PITA 3.193E-5 2.290E-3 1.759E-2 3.892E-2 11 483
16 hsa-miR-148b:PITA hsa-miR-148b:PITA TOP PITA 3.193E-5 2.290E-3 1.759E-2 3.892E-2 11 483
17 hsa-miR-152:PITA hsa-miR-152:PITA TOP PITA 3.193E-5 2.290E-3 1.759E-2 3.892E-2 11 483
18 miR-145:PicTar miR-145:PicTar PicTar 3.571E-5 2.419E-3 1.858E-2 4.354E-2 8 247
19 CTTTGTA,MIR-524:MSigDB CTTTGTA,MIR-524:MSigDB MSigDB 4.117E-5 2.642E-3 2.030E-2
5.019E-2
 10 409
20 hsa-miR-888:PITA hsa-miR-888:PITA TOP PITA 5.145E-5 3.136E-3 2.409E-2
6.271E-2
 10 420
21 hsa-miR-448:PITA hsa-miR-448:PITA TOP PITA 7.297E-5 4.166E-3 3.201E-2
8.895E-2
 10 438
22 hsa-miR-299:miRTarbase hsa-miR-299:miRTarbase miRTarbase 7.518E-5 4.166E-3 3.201E-2
9.164E-2
 2 3
23 miR-32:PicTar miR-32:PicTar PicTar 8.167E-5 4.190E-3 3.219E-2
9.955E-2
 10 444
24 hsa-miR-768-3p:PITA hsa-miR-768-3p:PITA TOP PITA 8.403E-5 4.190E-3 3.219E-2
1.024E-1
 9 359
25 hsa-miR-889:PITA hsa-miR-889:PITA TOP PITA 8.618E-5 4.190E-3 3.219E-2
1.051E-1
 8 280
26 TACTTGA,MIR-26A:MSigDB TACTTGA,MIR-26A:MSigDB MSigDB 9.280E-5 4.190E-3 3.219E-2
1.131E-1
 8 283
27 TACTTGA,MIR-26B:MSigDB TACTTGA,MIR-26B:MSigDB MSigDB 9.280E-5 4.190E-3 3.219E-2
1.131E-1
 8 283
28 miR-302c-star:PicTar miR-302c-star:PicTar PicTar 1.079E-4 4.695E-3 3.608E-2
1.315E-1
 9 371
29 hsa-miR-26b:PITA hsa-miR-26b:PITA TOP PITA 1.372E-4 5.293E-3 4.067E-2
1.673E-1
 10 473
30 hsa-miR-26a:PITA hsa-miR-26a:PITA TOP PITA 1.372E-4 5.293E-3 4.067E-2
1.673E-1
 10 473
31 hsa-miR-1297:PITA hsa-miR-1297:PITA TOP PITA 1.372E-4 5.293E-3 4.067E-2
1.673E-1
 10 473
32 hsa-miR-190b:PITA hsa-miR-190b:PITA TOP PITA 1.440E-4 5.293E-3 4.067E-2
1.755E-1
 6 157
33 hsa-miR-190:PITA hsa-miR-190:PITA TOP PITA 1.440E-4 5.293E-3 4.067E-2
1.755E-1
 6 157
34 hsa-miR-557:PITA hsa-miR-557:PITA TOP PITA 1.520E-4 5.293E-3 4.067E-2
1.852E-1
 8 304
35 hsa-miR-507:PITA hsa-miR-507:PITA TOP PITA 1.520E-4 5.293E-3 4.067E-2
1.852E-1
 8 304
36 TTTGCAC,MIR-19B:MSigDB TTTGCAC,MIR-19B:MSigDB MSigDB 1.626E-4 5.357E-3 4.116E-2
1.982E-1
 10 483
37 TTTGCAC,MIR-19A:MSigDB TTTGCAC,MIR-19A:MSigDB MSigDB 1.626E-4 5.357E-3 4.116E-2
1.982E-1
 10 483
38 hsa-miR-380:PITA hsa-miR-380:PITA TOP PITA 1.827E-4 5.809E-3 4.463E-2
2.228E-1
 9 398
39 GTTTGTT,MIR-495:MSigDB GTTTGTT,MIR-495:MSigDB MSigDB 1.928E-4 5.809E-3 4.463E-2
2.350E-1
 7 236
40 hsa-miR-145:PITA hsa-miR-145:PITA TOP PITA 1.932E-4 5.809E-3 4.463E-2
2.356E-1
 9 401
41 ACATATC,MIR-190:MSigDB ACATATC,MIR-190:MSigDB MSigDB 1.954E-4 5.809E-3 4.463E-2
2.382E-1
 4 57
42 miR-301:PicTar miR-301:PicTar PicTar 2.149E-4 6.236E-3 4.791E-2
2.619E-1
 10 500
43 miR-92:PicTar miR-92:PicTar PicTar 2.404E-4 6.816E-3
5.237E-2
2.931E-1
 9 413
44 TGCACTT,MIR-519A:MSigDB TGCACTT,MIR-519A:MSigDB MSigDB 2.769E-4 7.128E-3
5.477E-2
3.376E-1
 9 421
45 TGCACTT,MIR-519C:MSigDB TGCACTT,MIR-519C:MSigDB MSigDB 2.769E-4 7.128E-3
5.477E-2
3.376E-1
 9 421
46 TGCACTT,MIR-519B:MSigDB TGCACTT,MIR-519B:MSigDB MSigDB 2.769E-4 7.128E-3
5.477E-2
3.376E-1
 9 421
47 hsa-miR-525-5p:PITA hsa-miR-525-5p:PITA TOP PITA 2.807E-4 7.128E-3
5.477E-2
3.421E-1
 7 251
48 hsa-miR-520a-5p:PITA hsa-miR-520a-5p:PITA TOP PITA 2.807E-4 7.128E-3
5.477E-2
3.421E-1
 7 251
49 miR-141:PicTar miR-141:PicTar PicTar 2.993E-4 7.447E-3
5.722E-2
3.649E-1
 8 336
50 hsa-miR-411:TargetScan hsa-miR-411:TargetScan TargetScan 3.059E-4 7.458E-3
5.730E-2
3.729E-1
 4 64
Show 45 more annotations

17: Drug [Display Chart] 19679 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C032668 1-nitropyrene CTD 1.875E-14 3.691E-10 3.862E-9 3.691E-10 16 245
2 C506614 PD 0325901 CTD 7.284E-14 7.167E-10 7.500E-9 1.433E-9 12 108
3 D014747 Vinblastine CTD 1.233E-11 8.086E-8 8.461E-7 2.426E-7 14 260
4 904 UP 5109870; Up 200; 25uM; MCF7; HT HG-U133A EA Broad Institute CMAP 2.450E-10 1.097E-6 1.148E-5 4.821E-6 11 166
5 5021 UP Suloctidil [54063-56-8]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP 3.162E-10 1.097E-6 1.148E-5 6.222E-6 11 170
6 C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) CTD 3.344E-10 1.097E-6 1.148E-5 6.581E-6 16 468
7 C113580 U 0126 CTD 7.383E-10 1.840E-6 1.925E-5 1.453E-5 15 422
8 D020148 Butyric Acid CTD 7.479E-10 1.840E-6 1.925E-5 1.472E-5 10 139
9 D014302 Trinitrobenzenesulfonic Acid CTD 2.358E-9 4.634E-6 4.850E-5 4.640E-5 14 388
10 2651 UP Suloctidil [54063-56-8]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP 2.458E-9 4.634E-6 4.850E-5 4.836E-5 10 157
11 2338 UP Mebendazole [31431-39-7]; Up 200; 13.6uM; HL60; HT HG-U133A Broad Institute CMAP 2.614E-9 4.634E-6 4.850E-5 5.144E-5 10 158
12 1220 UP SAHA; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 2.953E-9 4.634E-6 4.850E-5 5.812E-5 10 160
13 C031721 naphthalene CTD 3.061E-9 4.634E-6 4.850E-5 6.025E-5 14 396
14 D003078 Colchicine CTD 4.394E-9 6.176E-6 6.463E-5 8.646E-5 11 218
15 1212 UP Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 5.308E-9 6.964E-6 7.287E-5 1.045E-4 10 170
16 C013186 2,3-pentanedione CTD 5.867E-9 7.215E-6 7.551E-5 1.154E-4 9 126
17 5023 UP Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 6.641E-9 7.687E-6 8.044E-5 1.307E-4 10 174
18 1393 UP Nocodazole [31430-18-9]; Up 200; 13.2uM; HL60; HG-U133A Broad Institute CMAP 7.412E-9 7.701E-6 8.059E-5 1.459E-4 10 176
19 C095105 bexarotene CTD 7.521E-9 7.701E-6 8.059E-5 1.480E-4 14 425
20 1951 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HG-U133A Broad Institute CMAP 7.827E-9 7.701E-6 8.059E-5 1.540E-4 10 177
21 D003513 Cycloheximide CTD 1.069E-8 1.002E-5 1.048E-4 2.104E-4 14 437
22 1627 UP Cefoperazone dihydrate; Up 200; 5.8uM; HL60; HG-U133A Broad Institute CMAP 1.976E-8 1.767E-5 1.849E-4 3.888E-4 10 195
23 C093973 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one CTD 2.276E-8 1.948E-5 2.038E-4 4.480E-4 13 389
24 D008769 Methylnitronitrosoguanidine CTD 3.062E-8 2.511E-5 2.628E-4 6.027E-4 11 263
25 1791 UP Azaguanine-8 [134-58-7]; Up 200; 26.2uM; PC3; HT HG-U133A Broad Institute CMAP 4.241E-8 3.339E-5 3.494E-4 8.347E-4 9 158
26 D007529 Isoflavones CTD 5.431E-8 4.111E-5 4.302E-4 1.069E-3 10 217
27 D010656 Phenylephrine CTD 5.738E-8 4.182E-5 4.376E-4 1.129E-3 14 500
28 1626 UP Etoposide [33419-42-0]; Up 200; 6.8uM; HL60; HG-U133A Broad Institute CMAP 6.840E-8 4.807E-5 5.031E-4 1.346E-3 9 167
29 1793 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 7.577E-8 5.142E-5 5.381E-4 1.491E-3 9 169
30 5501 UP Perhexiline maleate [6724-53-4]; Up 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP 7.971E-8 5.155E-5 5.395E-4 1.569E-3 9 170
31 C432165 anthra(1,9-cd)pyrazol-6(2H)-one CTD 8.281E-8 5.155E-5 5.395E-4 1.630E-3 11 290
32 887 UP celastrol; Up 200; 2.5uM; MCF7; HT HG-U133A EA Broad Institute CMAP 8.383E-8 5.155E-5 5.395E-4 1.650E-3 9 171
33 D002713 Chlorine CTD 9.246E-8 5.319E-5 5.566E-4 1.820E-3 12 363
34 1050 UP Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A EA Broad Institute CMAP 9.262E-8 5.319E-5 5.566E-4 1.823E-3 9 173
35 2456 UP Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; HL60; HT HG-U133A Broad Institute CMAP 9.731E-8 5.319E-5 5.566E-4 1.915E-3 9 174
36 1063 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP 9.731E-8 5.319E-5 5.566E-4 1.915E-3 9 174
37 7245 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.022E-7 5.415E-5 5.666E-4 2.011E-3 9 175
38 6546 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 1.073E-7 5.415E-5 5.666E-4 2.112E-3 9 176
39 C496197 trans-10,cis-12-conjugated linoleic acid CTD 1.073E-7 5.415E-5 5.666E-4 2.112E-3 9 176
40 1891 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HG-U133A Broad Institute CMAP 1.240E-7 6.100E-5 6.384E-4 2.440E-3 9 179
41 C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one CTD 1.353E-7 6.493E-5 6.794E-4 2.662E-3 12 376
42 593 UP geldanamycin; Up 200; 1uM; MCF7; HG-U133A Broad Institute CMAP 1.429E-7 6.540E-5 6.844E-4 2.812E-3 9 182
43 1905 UP Thioridazine hydrochloride [130-61-0]; Up 200; 9.8uM; PC3; HG-U133A Broad Institute CMAP 1.429E-7 6.540E-5 6.844E-4 2.812E-3 9 182
44 1772 DN Hydrocotarnine hydrobromide [5985-00-2]; Down 200; 13.2uM; HL60; HG-U133A Broad Institute CMAP 1.568E-7 7.015E-5 7.341E-4 3.087E-3 9 184
45 CID002724682 lithium diisopropylamine Stitch 1.900E-7 8.276E-5 8.660E-4 3.740E-3 4 12
46 MESH:D011471/C017947-M Prostatic Neoplasms affected by sodium arsenite CTD Marker 1.935E-7 8.276E-5 8.660E-4 3.807E-3 8 136
47 D017258 Medroxyprogesterone Acetate CTD 2.004E-7 8.392E-5 8.782E-4 3.944E-3 12 390
48 D015056 1-Methyl-3-isobutylxanthine CTD 2.060E-7 8.446E-5 8.838E-4 4.054E-3 12 391
49 C488369 dasatinib CTD 2.145E-7 8.497E-5 8.892E-4 4.222E-3 13 472
50 D005978 Glutathione CTD 2.159E-7 8.497E-5 8.892E-4 4.249E-3 11 319
Show 45 more annotations

18: Disease [Display Chart] 1857 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0917798 Cerebral Ischemia DisGeNET BeFree 1.400E-8 2.599E-5 2.106E-4 2.599E-5 11 189
2 umls:C0151744 Myocardial Ischemia DisGeNET Curated 1.275E-7 1.184E-4 9.595E-4 2.368E-4 14 413
3 umls:C0278488 Carcinoma breast stage IV DisGeNET BeFree 7.353E-7 4.551E-4 3.688E-3 1.365E-3 12 341
4 umls:C0038356 Stomach Neoplasms DisGeNET Curated 1.002E-6 4.653E-4 3.771E-3 1.861E-3 14 490
5 umls:C0032580 Adenomatous Polyposis Coli DisGeNET Curated 1.779E-6 5.669E-4 4.594E-3 3.304E-3 12 371
6 umls:C0032962 Pregnancy Complications DisGeNET Curated 1.832E-6 5.669E-4 4.594E-3 3.401E-3 6 63
7 umls:C0007785 Cerebral Infarction DisGeNET Curated 3.543E-6 9.400E-4 7.618E-3 6.580E-3 10 265
8 umls:C0279000 Liver and Intrahepatic Biliary Tract Carcinoma DisGeNET BeFree 6.479E-6 1.504E-3 1.219E-2 1.203E-2 13 496
9 umls:C1318544 M5b Acute differentiated monocytic leukemia DisGeNET BeFree 7.476E-6 1.543E-3 1.250E-2 1.388E-2 6 80
10 umls:C0334579 Anaplastic astrocytoma DisGeNET Curated 1.609E-5 2.875E-3 2.330E-2 2.988E-2 7 137
11 umls:C0034069 Pulmonary Fibrosis DisGeNET Curated 1.703E-5 2.875E-3 2.330E-2 3.162E-2 10 317
12 umls:C0740391 Middle Cerebral Artery Occlusion DisGeNET BeFree 3.959E-5 6.126E-3 4.964E-2
7.351E-2
 6 107
13 umls:C1658953 tumor vasculature DisGeNET BeFree 4.394E-5 6.277E-3
5.087E-2
8.160E-2
 6 109
14 umls:C0030354 Papilloma DisGeNET Curated 5.116E-5 6.786E-3
5.499E-2
9.500E-2
 7 164
15 umls:C1134719 Invasive Ductal Breast Carcinoma DisGeNET Curated 5.906E-5 7.312E-3
5.926E-2
1.097E-1
 8 228
16 umls:C1096458 Vascular occlusion DisGeNET BeFree 6.848E-5 7.846E-3
6.359E-2
1.272E-1
 3 14
17 umls:C0947751 Vascular inflammations DisGeNET BeFree 7.183E-5 7.846E-3
6.359E-2
1.334E-1
 6 119
18 umls:C0011875 Diabetic Angiopathies DisGeNET Curated 1.274E-4 1.184E-2
9.593E-2
2.365E-1
 4 44
19 umls:C0598894 Monocytic leukemia DisGeNET BeFree 1.274E-4 1.184E-2
9.593E-2
2.365E-1
 4 44
20 umls:C0027626 Neoplasm Invasiveness DisGeNET Curated 1.275E-4 1.184E-2
9.593E-2
2.367E-1
 6 132
21 umls:C0278883 Metastatic melanoma DisGeNET BeFree 1.498E-4 1.281E-2
1.038E-1
2.781E-1
 9 333
22 umls:C0001883 Airway Obstruction DisGeNET Curated 1.517E-4 1.281E-2
1.038E-1
2.818E-1
 4 46
23 umls:C0751956 Acute Cerebrovascular Accidents DisGeNET BeFree 1.944E-4 1.569E-2
1.272E-1
3.609E-1
 4 49
24 umls:C1368683 Epithelioma DisGeNET BeFree 2.212E-4 1.710E-2
1.385E-1
4.107E-1
 8 276
25 umls:C0034065 Pulmonary Embolism DisGeNET Curated 2.450E-4 1.710E-2
1.385E-1
4.550E-1
 4 52
26 umls:C0035412 Rhabdomyosarcoma DisGeNET Curated 2.676E-4 1.710E-2
1.385E-1
4.968E-1
 9 360
27 umls:C1519670 Tumor Angiogenesis DisGeNET BeFree 2.748E-4 1.710E-2
1.385E-1
5.102E-1
 10 443
28 umls:C0019880 Homocystinuria DisGeNET Curated 2.800E-4 1.710E-2
1.385E-1
5.200E-1
 3 22
29 umls:C0007193 Cardiomyopathy, Dilated DisGeNET Curated 3.021E-4 1.710E-2
1.385E-1
5.611E-1
 9 366
30 umls:C0279702 Conventional (Clear Cell) Renal Cell Carcinoma DisGeNET Curated 3.083E-4 1.710E-2
1.385E-1
5.724E-1
 9 367
31 umls:C0349649 Pulmonary lymphangioleiomyomatosis DisGeNET BeFree 3.206E-4 1.710E-2
1.385E-1
5.954E-1
 3 23
32 umls:C0494165 Secondary malignant neoplasm of liver DisGeNET BeFree 3.224E-4 1.710E-2
1.385E-1
5.986E-1
 10 452
33 umls:C0027659 Neoplasms, Experimental DisGeNET Curated 3.265E-4 1.710E-2
1.385E-1
6.064E-1
 4 56
34 umls:C0948008 Ischemic stroke DisGeNET Curated 3.272E-4 1.710E-2
1.385E-1
6.076E-1
 9 370
35 umls:C0007115 Malignant neoplasm of thyroid DisGeNET BeFree 3.281E-4 1.710E-2
1.385E-1
6.092E-1
 10 453
36 umls:C0001510 Postoperative adhesion DisGeNET BeFree 3.385E-4 1.710E-2
1.385E-1
6.285E-1
 2 5
37 umls:C3539878 Triple Negative Breast Neoplasms DisGeNET BeFree 3.456E-4 1.710E-2
1.385E-1
6.419E-1
 10 456
38 umls:C1292778 Chronic myeloproliferative disorder DisGeNET BeFree 3.498E-4 1.710E-2
1.385E-1
6.496E-1
 6 159
39 umls:C0007786 Brain Ischemia DisGeNET Curated 3.680E-4 1.752E-2
1.420E-1
6.833E-1
 5 104
40 umls:C0740457 Malignant neoplasm of kidney DisGeNET BeFree 4.371E-4 1.915E-2
1.552E-1
8.116E-1
 9 385
41 umls:C0000786 Spontaneous abortion DisGeNET Curated 4.379E-4 1.915E-2
1.552E-1
8.131E-1
 5 108
42 umls:C1378703 Renal carcinoma DisGeNET BeFree 4.459E-4 1.915E-2
1.552E-1
8.280E-1
 10 471
43 umls:C1512409 Hepatocarcinogenesis DisGeNET BeFree 4.459E-4 1.915E-2
1.552E-1
8.280E-1
 10 471
44 umls:C0018552 Hamartoma DisGeNET Curated 4.536E-4 1.915E-2
1.552E-1
8.424E-1
 4 61
45 umls:C0311370 Lupus anticoagulant disorder DisGeNET BeFree 4.647E-4 1.918E-2
1.554E-1
8.630E-1
 3 26
46 umls:C0040136 Thyroid Neoplasm DisGeNET Curated 5.024E-4 2.028E-2
1.643E-1
9.330E-1
 8 312
47 umls:C0038443 Stress, Psychological DisGeNET BeFree 5.132E-4 2.028E-2
1.643E-1
9.530E-1
 4 63
48 umls:C0005695 Bladder Neoplasm DisGeNET Curated 5.464E-4 2.075E-2
1.681E-1
1.000E0
 8 316
49 umls:C0016057 Fibrosarcoma DisGeNET Curated 5.474E-4 2.075E-2
1.681E-1
1.000E0
 7 241
50 umls:C0034067 Pulmonary Emphysema DisGeNET Curated 5.647E-4 2.097E-2
1.700E-1
1.000E0
 6 174
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