Toppgene analysis for aggregated_1964_log, IC28, positive side

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1: GO: Molecular Function [Display Chart] 461 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0045499 chemorepellent activity 4.033E-5 1.377E-2
9.240E-2
1.859E-2 4 28
2 GO:0044548 S100 protein binding 8.959E-5 1.377E-2
9.240E-2
4.130E-2 3 13
3 GO:0004859 phospholipase inhibitor activity 8.959E-5 1.377E-2
9.240E-2
4.130E-2 3 13
4 GO:0048306 calcium-dependent protein binding 1.275E-4 1.470E-2
9.864E-2
5.879E-2
5 70
5 GO:0055102 lipase inhibitor activity 2.492E-4 2.197E-2
1.474E-1
1.149E-1
3 18
6 GO:0019834 phospholipase A2 inhibitor activity 2.859E-4 2.197E-2
1.474E-1
1.318E-1
2 4
7 GO:0030215 semaphorin receptor binding 4.608E-4 3.035E-2
2.037E-1
2.124E-1
3 22
Show 2 more annotations

2: GO: Biological Process [Display Chart] 2952 annotations before applied cutoff / 18785 genes in category

No results to display

3: GO: Cellular Component [Display Chart] 312 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016324 apical plasma membrane 1.309E-4 3.375E-2
2.134E-1
4.085E-2 10 337
2 GO:0045177 apical part of cell 2.164E-4 3.375E-2
2.134E-1
6.750E-2
11 429

4: Human Phenotype [Display Chart] 486 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0011499 Mydriasis 5.771E-5 1.484E-2
1.004E-1
2.804E-2 2 2
2 HP:0000458 Anosmia 6.106E-5 1.484E-2
1.004E-1
2.967E-2 4 29

5: Mouse Phenotype [Display Chart] 1972 annotations before applied cutoff / 9299 genes in category

No results to display

6: Domain [Display Chart] 822 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1.10.220.10 - Gene3D 9.496E-5 1.366E-2
9.954E-2
7.806E-2
3 13
2 IPR018502 Annexin repeat InterPro 1.202E-4 1.366E-2
9.954E-2
9.883E-2
3 14
3 PS00223 ANNEXIN PROSITE 1.202E-4 1.366E-2
9.954E-2
9.883E-2
3 14
4 SM00335 ANX SMART 1.202E-4 1.366E-2
9.954E-2
9.883E-2
3 14
5 PF00191 Annexin Pfam 1.202E-4 1.366E-2
9.954E-2
9.883E-2
3 14
6 IPR018252 Annexin repeat CS InterPro 1.202E-4 1.366E-2
9.954E-2
9.883E-2
3 14
7 IPR008030 NmrA-like InterPro 1.494E-4 1.366E-2
9.954E-2
1.228E-1
2 3
8 PF05368 NmrA Pfam 1.494E-4 1.366E-2
9.954E-2
1.228E-1
2 3
9 IPR001464 Annexin InterPro 1.495E-4 1.366E-2
9.954E-2
1.229E-1
3 15
10 IPR027231 Semaphorin InterPro 3.650E-4 3.000E-2
2.187E-1
3.000E-1
3 20
11 PS00303 S100 CABP PROSITE 9.031E-4 4.786E-2
3.489E-1
7.423E-1
3 27
12 PF01023 S 100 Pfam 9.031E-4 4.786E-2
3.489E-1
7.423E-1
3 27
13 IPR001751 S100/CaBP-9k CS InterPro 1.006E-3 4.786E-2
3.489E-1
8.271E-1
3 28
14 IPR013787 S100 Ca-bd sub InterPro 1.006E-3 4.786E-2
3.489E-1
8.271E-1
3 28
15 SM01394 S 100 SMART 1.006E-3 4.786E-2
3.489E-1
8.271E-1
3 28
16 PF01403 Sema Pfam 1.359E-3 4.786E-2
3.489E-1
1.000E0
3 31
17 SM00630 Sema SMART 1.359E-3 4.786E-2
3.489E-1
1.000E0
3 31
18 PS51004 SEMA PROSITE 1.359E-3 4.786E-2
3.489E-1
1.000E0
3 31
19 IPR001627 Semap dom InterPro 1.359E-3 4.786E-2
3.489E-1
1.000E0
3 31
20 IPR004032 PMP22 EMP MP20 InterPro 1.743E-3 4.786E-2
3.489E-1
1.000E0
2 9
21 PS01222 PMP22 2 PROSITE 1.743E-3 4.786E-2
3.489E-1
1.000E0
2 9
22 PS01221 PMP22 1 PROSITE 1.743E-3 4.786E-2
3.489E-1
1.000E0
2 9
23 PS50963 LINK 2 PROSITE 3.707E-3 4.786E-2
3.489E-1
1.000E0
2 13
24 IPR000538 Link dom InterPro 3.707E-3 4.786E-2
3.489E-1
1.000E0
2 13
25 SM00445 LINK SMART 3.707E-3 4.786E-2
3.489E-1
1.000E0
2 13
26 PS01241 LINK 1 PROSITE 3.707E-3 4.786E-2
3.489E-1
1.000E0
2 13
27 PF00193 Xlink Pfam 3.707E-3 4.786E-2
3.489E-1
1.000E0
2 13
28 IPR016201 PSI InterPro 3.745E-3 4.786E-2
3.489E-1
1.000E0
3 44
29 SM00423 PSI SMART 4.249E-3 4.786E-2
3.489E-1
1.000E0
3 46
30 1.20.1110.10 - Gene3D 5.624E-3 4.786E-2
3.489E-1
1.000E0
2 16
31 IPR023298 ATPase P-typ TM dom InterPro 5.624E-3 4.786E-2
3.489E-1
1.000E0
2 16
32 PF00041 fn3 Pfam 6.013E-3 4.786E-2
3.489E-1
1.000E0
5 162
33 PF00689 Cation ATPase C Pfam 6.344E-3 4.786E-2
3.489E-1
1.000E0
2 17
34 IPR006068 ATPase P-typ cation-transptr C InterPro 6.344E-3 4.786E-2
3.489E-1
1.000E0
2 17
35 PF13673 Acetyltransf 10 Pfam 7.099E-3 4.786E-2
3.489E-1
1.000E0
1 1
36 IPR009511 MAD1/Cdc20-bound-Mad2-bd InterPro 7.099E-3 4.786E-2
3.489E-1
1.000E0
1 1
37 IPR033078 TNC InterPro 7.099E-3 4.786E-2
3.489E-1
1.000E0
1 1
38 IPR030482 PDRG1 InterPro 7.099E-3 4.786E-2
3.489E-1
1.000E0
1 1
39 IPR003934 EMP 3 InterPro 7.099E-3 4.786E-2
3.489E-1
1.000E0
1 1
40 IPR031714 DUF4726 InterPro 7.099E-3 4.786E-2
3.489E-1
1.000E0
1 1
41 PS00291 PRION 1 PROSITE 7.099E-3 4.786E-2
3.489E-1
1.000E0
1 1
42 IPR018401 Lysosomal-assoc TM prot4B InterPro 7.099E-3 4.786E-2
3.489E-1
1.000E0
1 1
43 PF11587 Prion bPrPp Pfam 7.099E-3 4.786E-2
3.489E-1
1.000E0
1 1
44 IPR009450 Plno GlcNAc GPI2 InterPro 7.099E-3 4.786E-2
3.489E-1
1.000E0
1 1
45 IPR006449 Squal synth InterPro 7.099E-3 4.786E-2
3.489E-1
1.000E0
1 1
46 IPR019845 Squalene/phytoene synthase CS InterPro 7.099E-3 4.786E-2
3.489E-1
1.000E0
1 1
47 IPR025860 Prion N dom InterPro 7.099E-3 4.786E-2
3.489E-1
1.000E0
1 1
48 PF03083 MtN3 slv Pfam 7.099E-3 4.786E-2
3.489E-1
1.000E0
1 1
49 PF04874 Mak16 Pfam 7.099E-3 4.786E-2
3.489E-1
1.000E0
1 1
50 PF06573 Churchill Pfam 7.099E-3 4.786E-2
3.489E-1
1.000E0
1 1
Show 45 more annotations

7: Pathway [Display Chart] 678 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 198912 Prostaglandin Synthesis and Regulation BioSystems: WikiPathways 3.683E-6 2.497E-3 1.772E-2 2.497E-3 5 31

8: Pubmed [Display Chart] 17221 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19199708 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Pubmed 7.339E-11 1.264E-6 1.306E-5 1.264E-6 13 414
2 20628624:gr Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". GeneRIF 8.052E-10 4.622E-6 4.775E-5 1.387E-5 9 172
3 20628624 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". Pubmed 8.052E-10 4.622E-6 4.775E-5 1.387E-5 9 172
4 19834535 Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. Pubmed 8.025E-9 2.169E-5 2.241E-4 1.382E-4 7 99
5 19834535:gr Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. GeneRIF 8.025E-9 2.169E-5 2.241E-4 1.382E-4 7 99
6 22940583 Structure of an asymmetric ternary protein complex provides insight for membrane interaction. Pubmed 1.687E-8 2.169E-5 2.241E-4 2.906E-4 3 3
7 16984913 Identification of an AHNAK binding motif specific for the Annexin2/S100A10 tetramer. Pubmed 1.687E-8 2.169E-5 2.241E-4 2.906E-4 3 3
8 23275167 Structure of a C-terminal AHNAK peptide in a 1:2:2 complex with S100A10 and an acetylated N-terminal peptide of annexin A2. Pubmed 1.687E-8 2.169E-5 2.241E-4 2.906E-4 3 3
9 16984913:gr Identification of an AHNAK binding motif specific for the Annexin2/S100A10 tetramer. GeneRIF 1.687E-8 2.169E-5 2.241E-4 2.906E-4 3 3
10 23931152 The Annexin A2/p11 complex is required for efficient invasion of Salmonella Typhimurium in epithelial cells. Pubmed 1.687E-8 2.169E-5 2.241E-4 2.906E-4 3 3
11 23275167:gr Structure of a C-terminal AHNAK peptide in a 1:2:2 complex with S100A10 and an acetylated N-terminal peptide of annexin A2. GeneRIF 1.687E-8 2.169E-5 2.241E-4 2.906E-4 3 3
12 14699089 AHNAK interaction with the annexin 2/S100A10 complex regulates cell membrane cytoarchitecture. Pubmed 1.687E-8 2.169E-5 2.241E-4 2.906E-4 3 3
13 22940583:gr Structure of an asymmetric ternary protein complex provides insight for membrane interaction. GeneRIF 1.687E-8 2.169E-5 2.241E-4 2.906E-4 3 3
14 22261194 Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Pubmed 1.764E-8 2.169E-5 2.241E-4 3.037E-4 6 64
15 18164291 Heterogeneity and timing of translocation and membrane-mediated assembly of different annexins. Pubmed 1.681E-7 1.809E-4 1.869E-3 2.895E-3 3 5
16 18164291:gr Heterogeneity and timing of translocation and membrane-mediated assembly of different annexins. GeneRIF 1.681E-7 1.809E-4 1.869E-3 2.895E-3 3 5
17 20551380 Proteomics characterization of extracellular space components in the human aorta. Pubmed 2.757E-7 2.793E-4 2.885E-3 4.748E-3 6 101
18 2138016 Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins. Pubmed 3.356E-7 3.211E-4 3.317E-3 5.779E-3 3 6
19 24189400 Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms. Pubmed 3.857E-7 3.495E-4 3.611E-3 6.641E-3 8 256
20 21423176 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for Ã?-Pix in negative regulation of focal adhesion maturation. Pubmed 8.876E-7 7.642E-4 7.895E-3 1.528E-2 8 286
21 15226301 Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1. Pubmed 1.401E-6 1.019E-3 1.053E-2 2.413E-2 3 9
22 22304920 PKC¿ promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Pubmed 1.588E-6 1.019E-3 1.053E-2 2.734E-2 6 136
23 16303743 Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Pubmed 1.996E-6 1.019E-3 1.053E-2 3.438E-2 9 430
24 23415230 SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action. Pubmed 1.998E-6 1.019E-3 1.053E-2 3.441E-2 3 10
25 20029029 Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Pubmed 2.487E-6 1.019E-3 1.053E-2 4.282E-2 5 82
26 19190083 Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. Pubmed 3.269E-6 1.019E-3 1.053E-2
5.630E-2
4 39
27 16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Pubmed 5.202E-6 1.019E-3 1.053E-2
8.959E-2
7 257
28 23861394 Lipid segregation and membrane budding induced by the peripheral membrane binding protein annexin A2. Pubmed 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
29 23637395 Annexin A2 and S100A10 regulate human papillomavirus type 16 entry and intracellular trafficking in human keratinocytes. Pubmed 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
30 15064349:gr Macrophage surface expression of annexins I and II in the phagocytosis of apoptotic lymphocytes. GeneRIF 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
31 20232238:gr Changes in extra cellular matrix remodelling and re-expression of fibronectin and tenascin-C splicing variants in human myocardial tissue of the right atrial auricle: implications for a targeted therapy of cardiovascular diseases using human SIP format antibodies. GeneRIF 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
32 23994525 Protein interactions between surface annexin A2 and S100A10 mediate adhesion of breast cancer cells to microvascular endothelial cells. Pubmed 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
33 20970165 Down-regulation of annexin A1 and A2 protein expression in intestinal-type sinonasal adenocarcinomas. Pubmed 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
34 23518350:gr Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression. GeneRIF 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
35 8955167 Partial mediation of glucocorticoid antiproliferative effects by lipocortins. Pubmed 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
36 20708078 Cryptic domains of tenascin-C differentially control fibronectin fibrillogenesis. Pubmed 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
37 15849182 Annexin A2-S100A10 heterotetramer, a novel substrate of thioredoxin. Pubmed 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
38 24333422 Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation. Pubmed 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
39 24792713 De novo expression of fetal ED-A(+) fibronectin and B (+) tenascin-C splicing variants in human cardiac allografts: potential impact for targeted therapy of rejection. Pubmed 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
40 22057634 Ahnak1 abnormally localizes in muscular dystrophies and contributes to muscle vesicle release. Pubmed 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
41 22399798:gr Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4). GeneRIF 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
42 18786636:gr Human cellular prion protein interacts directly with clusterin protein. GeneRIF 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
43 23091277 N-terminal acetylation of annexin A2 is required for S100A10 binding. Pubmed 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
44 19724273:gr S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. GeneRIF 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
45 15150404 The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Pubmed 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
46 17971878 The p11/S100A10 light chain of annexin A2 is dispensable for annexin A2 association to endosomes and functions in endosomal transport. Pubmed 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
47 21849434:gr The human papillomavirus type 16 E5 oncoprotein translocates calpactin I to the perinuclear region. GeneRIF 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
48 22681645 Upregulated expression of annexin II is a prognostic marker for patients with gastric cancer. Pubmed 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
49 16230353:gr Phosphoinositide specificity of and mechanism of lipid domain formation by annexin A2-p11 heterotetramer. GeneRIF 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
50 20602103 The role of annexins I, II and IV in tumor development, progression and metastasis of human penile squamous cell carcinomas. Pubmed 6.629E-6 1.019E-3 1.053E-2
1.141E-1
2 2
Show 45 more annotations

9: Interaction [Display Chart] 3427 annotations before applied cutoff / 16534 genes in category

No results to display

10: Cytoband [Display Chart] 109 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1q21 1q21 1.726E-6 1.881E-4 9.919E-4 1.881E-4 6 93
2 1q32.1 1q32.1 5.651E-6 3.080E-4 1.624E-3 6.159E-4 6 114
3 6p21.1 6p21.1 2.957E-4 1.075E-2
5.666E-2
3.224E-2 4 82
4 20p11.23 20p11.23 4.317E-4 1.176E-2
6.203E-2
4.705E-2 3 38
5 18q22.3 18q22.3 1.507E-3 3.286E-2
1.733E-1
1.643E-1
2 15
6 1q31 1q31 2.430E-3 3.831E-2
2.020E-1
2.648E-1
2 19
7 7p11.2 7p11.2 2.560E-3 3.831E-2
2.020E-1
2.790E-1
3 70
8 8p21-p12 8p21-p12 3.866E-3 3.831E-2
2.020E-1
4.214E-1
1 1
9 8q22.3-q23.1 8q22.3-q23.1 3.866E-3 3.831E-2
2.020E-1
4.214E-1
1 1
10 6p21.1-p12 6p21.1-p12 3.866E-3 3.831E-2
2.020E-1
4.214E-1
1 1
11 5q12.1-q13.2 5q12.1-q13.2 3.866E-3 3.831E-2
2.020E-1
4.214E-1
1 1
12 15q22.2 15q22.2 6.820E-3 4.427E-2
2.335E-1
7.434E-1
2 32
13 20p13 20p13 7.341E-3 4.427E-2
2.335E-1
8.002E-1
3 102
14 1q21-q25 1q21-q25 7.717E-3 4.427E-2
2.335E-1
8.412E-1
1 2
15 14q21-q22 14q21-q22 7.717E-3 4.427E-2
2.335E-1
8.412E-1
1 2
16 8p23.1-p22 8p23.1-p22 7.717E-3 4.427E-2
2.335E-1
8.412E-1
1 2
17 8q22-q23 8q22-q23 7.717E-3 4.427E-2
2.335E-1
8.412E-1
1 2
18 8q11-q12 8q11-q12 7.717E-3 4.427E-2
2.335E-1
8.412E-1
1 2
19 20p12-p11.2 20p12-p11.2 7.717E-3 4.427E-2
2.335E-1
8.412E-1
1 2
Show 14 more annotations

11: Transcription Factor Binding Site [Display Chart] 451 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 71 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 404 Annexins genenames.org 2.918E-5 2.072E-3 1.004E-2 2.072E-3 3 13
2 736 Immunoglobulin like domain containing|Semaphorins genenames.org 1.135E-4 3.123E-3 1.514E-2 8.060E-3 3 20
3 459 S100 calcium binding proteins|EF-hand domain containing genenames.org 1.320E-4 3.123E-3 1.514E-2 9.370E-3 3 21
4 743 Short chain dehydrogenase/reductase superfamily genenames.org 4.814E-4 8.544E-3 4.141E-2 3.418E-2 4 76
5 555 Fibronectin type III domain containing|Immunoglobulin like domain containing genenames.org 1.022E-3 1.451E-2
7.032E-2
7.254E-2
5 160
6 1186 Type II classical cadherins genenames.org 1.704E-3 2.016E-2
9.772E-2
1.210E-1
2 13
7 680 Phosphatidylinositol glycan anchor biosynthesis genenames.org 4.474E-3 4.538E-2
2.200E-1
3.177E-1
2 21
Show 2 more annotations

13: Coexpression [Display Chart] 6082 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2293 Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.934E-15 3.609E-11 3.353E-10 3.609E-11 20 315
2 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.727E-11 1.742E-7 1.618E-6 3.483E-7 19 460
3 M4433 Genes down-regulated in comparison of naive B cells versus memory IgG IgA B cells. MSigDB C7: Immunologic Signatures (v5.1) 2.808E-10 4.836E-7 4.493E-6 1.708E-6 13 198
4 M3017 Genes down-regulated in comparison of naive versus memory CD8 T cells (day 40+ after LCMV-Armstrong infection). MSigDB C7: Immunologic Signatures (v5.1) 3.181E-10 4.836E-7 4.493E-6 1.934E-6 13 200
5 GSE15330 LYMPHOID MULTIPOTENT VS MEGAKARYOCYTE ERYTHROID PROGENITOR IKAROS KO DN Genes down-regulated in IKZF1 [GeneID=10320] knockout: lymphoid-primed multipotent progenitors versus megakaryo-erythrocyte progenitors. MSigDB C7: Immunologic Signatures (v5.1) 9.729E-10 1.183E-6 1.099E-5 5.917E-6 12 177
6 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v5.1) 3.913E-9 3.966E-6 3.685E-5 2.380E-5 12 200
7 M19391 Genes down-regulated in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.410E-9 5.570E-6 5.174E-5 3.899E-5 17 480
8 M2240 Genes up-regulated upon overexpression of PARVB [GeneID=29780] in MDA-MB-231 cells (breast cancer) cultured in 3D Matrigel only. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.950E-9 6.228E-6 5.786E-5 5.444E-5 16 429
9 M2769 Genes down-regulated during early stages of differentiation of embryoid bodies from V6.5 embryonic stem cells. MSigDB C6: Oncogenic Signatures (v5.1) 9.216E-9 6.228E-6 5.786E-5 5.605E-5 11 172
10 M12621 Genes up-regulated in Wilm's tumor samples compared to fetal kidney. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.660E-8 1.009E-5 9.378E-5 1.009E-4 11 182
11 M1617 Genes down-regulated in aorta biopsies from mice treated with rosiglitazone [PubChem=77999]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.847E-8 1.021E-5 9.488E-5 1.123E-4 9 106
12 M19541 Genes commonly down-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.248E-8 1.646E-5 1.529E-4 1.975E-4 15 408
13 M3119 Genes down-regulated in comparison of naive T cells versus memory T cells. MSigDB C7: Immunologic Signatures (v5.1) 4.169E-8 1.735E-5 1.612E-4 2.536E-4 11 199
14 M5832 Genes down-regulated in comparison of naive CD8 T cells versus memory CD8 T cells. MSigDB C7: Immunologic Signatures (v5.1) 4.389E-8 1.735E-5 1.612E-4 2.669E-4 11 200
15 GSE33425 CD161 HIGH VS NEG CD8 TCELL DN Genes down-regulated in CD8 T cells: KLRB1 high [GeneID=3820] versus KLRB1- [GeneID=3820]. MSigDB C7: Immunologic Signatures (v5.1) 4.389E-8 1.735E-5 1.612E-4 2.669E-4 11 200
16 M1973 Genes up-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [GeneID=9589] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.564E-8 1.735E-5 1.612E-4 2.776E-4 13 302
17 M16524 Genes up-regulated in hepatocellular carcinoma (HCC) induced by diethylnitrosamine (DENA) [PubChem=5921]. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.167E-8 2.922E-5 2.715E-4 4.967E-4 7 60
18 M4065 Down-regulated at 24 h following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v5.1) 8.932E-8 3.018E-5 2.804E-4 5.433E-4 8 91
19 M14507 Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.306E-7 3.945E-5 3.665E-4 7.944E-4 15 454
20 M6323 Genes up-regulated in spleen from DUSP1 [GeneID=1843] knockout: control versus LPS. MSigDB C7: Immunologic Signatures (v5.1) 1.362E-7 3.945E-5 3.665E-4 8.285E-4 10 176
21 GSE13522 WT VS IFNAR KO SKIN DN Genes down-regulated in skin: wildtype (BALB/c) versus IFNAR1 [GeneID=3454] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.362E-7 3.945E-5 3.665E-4 8.285E-4 10 176
22 M7514 Genes down-regulated in NIH3T3 cells (fibroblasts) transformed by expression of contitutively active (Q63L) form of RHOA [GeneID=387] off plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.456E-7 4.024E-5 3.739E-4 8.853E-4 14 394
23 M8467 Genes up-regulated in peripheral blood mononuclear cells (PBMC) from sickle cell disease patients compared to those from healthy subjects. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.769E-7 4.679E-5 4.347E-4 1.076E-3 10 181
24 M11884 Genes up-regulated at the peak of an antigen response of naive CD8+ [GeneID=925;926] T-cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.203E-7 5.583E-5 5.187E-4 1.340E-3 13 346
25 M2506 Genes up-regulated in the neural crest stem cells (NCS), defined as p75+/HNK1+ [GeneID=4804;27087]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.956E-7 7.192E-5 6.682E-4 1.798E-3 9 146
26 M1484 Genes up-regulated in pancreatic cells from mice with double knockout of E2F1 [GeneID=1869] and E2F2 [GeneID=1870] compared to wild type. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.934E-7 7.978E-5 7.412E-4 2.393E-3 9 151
27 M988 Genes up-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.398E-7 7.978E-5 7.412E-4 2.675E-3 9 153
28 GSE25123 WT VS PPARG KO MACROPHAGE IL4 STIM DN Genes down-regulated in bone marrow-derived macrophages treated with IL4 [GeneID=3565]: wildtype versus PPARG [GeneID=5468] knockout. MSigDB C7: Immunologic Signatures (v5.1) 4.460E-7 7.978E-5 7.412E-4 2.713E-3 10 200
29 M3013 Genes down-regulated in comparison of naive versus effector CD8 T cells at the peak expansion phase (day8 after LCMV-Armstrong infection). MSigDB C7: Immunologic Signatures (v5.1) 4.460E-7 7.978E-5 7.412E-4 2.713E-3 10 200
30 M3022 Genes down-regulated in comparison of naive versus effector CD8 T cells at contraction (day 15 after LCMV-Armstrong infection). MSigDB C7: Immunologic Signatures (v5.1) 4.460E-7 7.978E-5 7.412E-4 2.713E-3 10 200
31 M5907 Genes defining late response to estrogen. MSigDB H: Hallmark Gene Sets (v5.1) 4.460E-7 7.978E-5 7.412E-4 2.713E-3 10 200
32 M6200 Genes up-regulated in polymorphonuclear leukocytes (24h): treated by heat killed HC60 cell (promyelocytic leukemia) lysate versus A. phagocytophilum infection. MSigDB C7: Immunologic Signatures (v5.1) 4.460E-7 7.978E-5 7.412E-4 2.713E-3 10 200
33 GSE26488 WT VS HDAC7 DELTAP TG OT2 THYMOCYTE WITH PEPTIDE INJECTION DN Genes down-regulated in dobule positive thymocytefrom OT-2 transgenic mice injected with agonist peptide: wildtype versus expressing deltaP form of HDAC7 [GeneID=51564]. MSigDB C7: Immunologic Signatures (v5.1) 4.460E-7 7.978E-5 7.412E-4 2.713E-3 10 200
34 M5677 Genes up-regulated in comparsion of ActCD8 versus ActCD8TGF (see Fig. 1 in the paper for details). MSigDB C7: Immunologic Signatures (v5.1) 4.460E-7 7.978E-5 7.412E-4 2.713E-3 10 200
35 M15908 Genes up-regulated in D-341 MED (OBR) cells (medulloblastoma) resistant to both carmustine and O6-BG [PubChem=2578;4578]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.755E-7 8.263E-5 7.677E-4 2.892E-3 5 26
36 M12225 Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.595E-7 9.453E-5 8.782E-4 3.403E-3 10 205
37 M2502 Genes whose expression changes in Calu-6 cells (lung cancer) by TNF [GeneID=7124] were blocked partially by p38 inhibitor LY479754. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.414E-7 1.054E-4 9.794E-4 3.901E-3 9 160
38 M1124 Pubertal genes up-regulated by TGFB1 [GeneID=7040]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.015E-6 1.624E-4 1.509E-3 6.170E-3 9 169
39 M5888 Cluster 2: late ATM [GeneID=472] dependent genes induced by ionizing radiation treatment. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.171E-6 1.743E-4 1.619E-3 7.125E-3 8 127
40 M6326 Genes up-regulated in spleen from wildtype mice: control versus LPS. MSigDB C7: Immunologic Signatures (v5.1) 1.175E-6 1.743E-4 1.619E-3 7.146E-3 9 172
41 GSE37301 PRO BCELL VS GRANULOCYTE MONOCYTE PROGENITOR DN Genes down-regulated in pro-B cells versus granulocyte-monocyte progenitors. MSigDB C7: Immunologic Signatures (v5.1) 1.175E-6 1.743E-4 1.619E-3 7.146E-3 9 172
42 M14555 Down-regulated at any timepoint following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v5.1) 1.243E-6 1.800E-4 1.673E-3 7.561E-3 8 128
43 M1542 Genes up-regulated in embryonic stem cells from TCEB3 [GeneID=6924] knockout mice. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.357E-6 1.919E-4 1.783E-3 8.252E-3 9 175
44 GSE15330 MEGAKARYOCYTE ERYTHROID VS GRANULOCYTE MONOCYTE PROGENITOR UP Genes up-regulated in megakaryo-erythrocyte progenitors versus granulo-monocyte progenitors. MSigDB C7: Immunologic Signatures (v5.1) 1.562E-6 2.112E-4 1.962E-3 9.502E-3 9 178
45 GSE13946 CTRL VS DSS COLITIS GD TCELL FROM COLON UP Genes up-regulated in gamma delta intraepithelial lymphocytes from colon: control versus colitis induced by dextran sulfate sodium (DSS). MSigDB C7: Immunologic Signatures (v5.1) 1.562E-6 2.112E-4 1.962E-3 9.502E-3 9 178
46 GSE14699 DELETIONAL TOLERANCE VS ACTIVATED CD8 TCELL UP Genes up-regulated in CD8 T cells: undergoing deletional tolerance versus activated. MSigDB C7: Immunologic Signatures (v5.1) 1.714E-6 2.266E-4 2.105E-3 1.042E-2 9 180
47 M2792 Genes down-regulated in retina cells from CRX [Gene ID=1406] knockout mice. MSigDB C6: Oncogenic Signatures (v5.1) 1.757E-6 2.274E-4 2.112E-3 1.069E-2 8 134
48 GSE14415 INDUCED TREG VS FOXP3 KO INDUCED TREG DN Genes down-regulated in induced T reg: wildtype versus non-functional FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v5.1) 1.878E-6 2.380E-4 2.211E-3 1.142E-2 9 182
49 M14043 Genes that correlated most highly with left ventricular mass (LVM) index. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.934E-6 2.400E-4 2.230E-3 1.176E-2 5 34
50 M2630 Genes down-regulated in mouse fibroblasts over-expressing E2F1 [Gene ID=1869] gene. MSigDB C6: Oncogenic Signatures (v5.1) 2.918E-6 3.549E-4 3.297E-3 1.774E-2 9 192
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2835 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 1.785E-24 5.060E-21 4.314E-20 5.060E-21 33 494
2 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 3.301E-22 4.679E-19 3.990E-18 9.358E-19 31 493
3 80Dn Top 500 Cluster 1 80Dn Top 500 Cluster 1 Brain Map - Allen iN 2.374E-14 2.243E-11 1.913E-10 6.729E-11 13 92
4 54Dn SubClass 54Dn 1SK Top 500 Cluster 0 54Dn SubClass 54Dn 1SK Top 500 Cluster 0 Brain Map - Allen iN 1.838E-13 1.072E-10 9.137E-10 5.210E-10 11 62
5 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 1.890E-13 1.072E-10 9.137E-10 5.358E-10 22 461
6 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 1.230E-12 5.810E-10 4.954E-9 3.486E-9 21 453
7 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 5.847E-12 2.368E-9 2.019E-8 1.657E-8 20 438
8 26Dn Top 500 All 26Dn Top 500 All Brain Map - Allen iN 5.457E-11 1.750E-8 1.492E-7 1.547E-7 20 496
9 PCBC ratio ECTO blastocyst vs ECTO amniotic fluid MSC cfr-2X-p05 ECTO blastocyst vs ECTO amniotic fluid MSC-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 5.555E-11 1.750E-8 1.492E-7 1.575E-7 16 290
10 54Dn Top 500 Cluster 0 54Dn Top 500 Cluster 0 Brain Map - Allen iN 8.623E-11 2.445E-8 2.085E-7 2.445E-7 12 138
11 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 4.087E-10 1.053E-7 8.983E-7 1.159E-6 19 496
12 gudmap dev gonad e13.5 M InterstitTestis Sma 500 dev gonad e13.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.430E-9 3.377E-7 2.880E-6 4.053E-6 16 362
13 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.115E-9 4.612E-7 3.932E-6 5.995E-6 16 372
14 54Dn SubClass 54Dn 2 Top 500 All 54Dn SubClass 54Dn 2 Top 500 All Brain Map - Allen iN 2.790E-9 5.435E-7 4.634E-6 7.910E-6 18 495
15 astrocytes Top 500 All astrocytes Top 500 All Brain Map - Barres 2.880E-9 5.435E-7 4.634E-6 8.165E-6 18 496
16 26Dn SubClass 26Dn 2 Top 500 All 26Dn SubClass 26Dn 2 Top 500 All Brain Map - Allen iN 3.067E-9 5.435E-7 4.634E-6 8.696E-6 18 498
17 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 3.830E-9 6.386E-7 5.446E-6 1.086E-5 17 445
18 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 5.333E-9 8.400E-7 7.163E-6 1.512E-5 17 455
19 PCBC ratio ECTO blastocyst vs ECTO UCB CD34+Z cfr-2X-p05 ECTO blastocyst vs ECTO UCB CD34+Z-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 6.297E-9 9.395E-7 8.011E-6 1.785E-5 14 294
20 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 7.847E-9 1.112E-6 9.485E-6 2.225E-5 17 467
21 gudmap developingKidney e15.5 Pelvic Mesenchyme 1000 k2 DevelopingKidney e15.5 Pelvic Mesenchyme emap-8241 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.004E-8 1.355E-6 1.156E-5 2.846E-5 14 305
22 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma k4 1000 dev gonad e13.5 F VascAssocMesenchStromOvary Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.101E-8 1.364E-6 1.163E-5 3.122E-5 11 168
23 Lungmap Mouse e18.5 Epithelial (GSE52583) SubClass AT1 Top 500 All Mouse Lung E18.5 Epithelial AT1 top 500 Lungmap Mouse Single Cell (Lungmap.net) 1.107E-8 1.364E-6 1.163E-5 3.138E-5 16 418
24 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k4 1000 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.322E-8 1.562E-6 1.332E-5 3.748E-5 13 261
25 80Dn SubClass 80Dn 1 Top 500 Cluster 0 80Dn SubClass 80Dn 1 Top 500 Cluster 0 Brain Map - Allen iN 1.546E-8 1.686E-6 1.438E-5 4.384E-5 17 489
26 80Dn SubClass 80Dn 1 Top 500 All 80Dn SubClass 80Dn 1 Top 500 All Brain Map - Allen iN 1.546E-8 1.686E-6 1.438E-5 4.384E-5 17 489
27 Lungmap Mouse e16.5 Epithelial SubClass Proliferative AT1 Progenitor Top 500 All Mouse Lung E16.5 Epithelial Proliferative AT1 Progenitor top 500 Lungmap Mouse Single Cell (Lungmap.net) 1.997E-8 2.097E-6 1.788E-5 5.662E-5 16 436
28 GSM605862 500 Myeloid Cells, MF.Thio5.II-480hi.PC, CD115+ MHC II- F480hi Siglec F-, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 2.341E-8 2.370E-6 2.021E-5 6.636E-5 16 441
29 80Dn Top 500 Cluster 4 80Dn Top 500 Cluster 4 Brain Map - Allen iN 2.631E-8 2.572E-6 2.194E-5 7.460E-5 9 106
30 Lungmap Mouse e16.5 Epithelial SubClass Proliferative AT1 Progenitor Top 500 Cluster 3 Mouse Lung E16.5 Epithelial Proliferative AT1 Progenitor c3 Lungmap Mouse Single Cell (Lungmap.net) 2.948E-8 2.786E-6 2.376E-5 8.358E-5 7 50
31 gudmap kidney e15.5 SmlBldVes Tie2 500 kidney e15.5 SmlBldVes Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.527E-8 5.968E-6 5.089E-5 1.850E-4 15 413
32 gudmap dev gonad e12.5 M gudmap devVasTestis Flk 500 dev gonad e12.5 M DevVasTestis Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.736E-8 5.968E-6 5.089E-5 1.910E-4 15 414
33 gudmap dev gonad e13.5 F gudmap devVascOvary Flk 500 dev gonad e13.5 F DevVascOvary Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 7.172E-8 6.162E-6 5.254E-5 2.033E-4 15 416
34 GSM854294 500 Myeloid Cells, DC.II+480lo.PC, F4/80lo MHC II+ CD11c+ CD115+, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 9.187E-8 7.479E-6 6.378E-5 2.604E-4 15 424
35 GSM538282 500 Myeloid Cells, MF.Lu, CD11chi CD11b- CD103- MHCII- SiglecF+, Lung, avg-3 Immgen.org, GSE15907 9.472E-8 7.479E-6 6.378E-5 2.685E-4 15 425
36 54Dn SubClass 54Dn 1 Top 500 Cluster 0 54Dn SubClass 54Dn 1 Top 500 Cluster 0 Brain Map - Allen iN 1.026E-7 7.479E-6 6.378E-5 2.910E-4 16 491
37 54Dn SubClass 54Dn 1 Top 500 All 54Dn SubClass 54Dn 1 Top 500 All Brain Map - Allen iN 1.026E-7 7.479E-6 6.378E-5 2.910E-4 16 491
38 gudmap dev gonad e12.5 F SupCellPrec Sry k3 1000 dev gonad e12.5 F SupCellPrec Sry k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.029E-7 7.479E-6 6.378E-5 2.916E-4 8 89
39 54Dn Top 500 Cluster 1 54Dn Top 500 Cluster 1 Brain Map - Allen iN 1.029E-7 7.479E-6 6.378E-5 2.917E-4 10 164
40 gudmap dev gonad e11.5 M GonMes Sma 500 dev gonad e11.5 M GonMes Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.206E-7 8.337E-6 7.109E-5 3.418E-4 15 433
41 GSM605856 500 Myeloid Cells, MF.Thio5.II+480int.PC, CD115+ MHC II+ F480lo SiglecF- CD11c+, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 1.206E-7 8.337E-6 7.109E-5 3.418E-4 15 433
42 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k2 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.269E-7 8.563E-6 7.302E-5 3.597E-4 9 127
43 GSM605865 500 Myeloid Cells, MF.Thio5.II-480int.PC, CD115+ MHCII- F480int SiglecF- CD11c+, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 1.358E-7 8.747E-6 7.459E-5 3.849E-4 15 437
44 gudmap dev gonad e11.5 F GonMes Sma 500 dev gonad e11.5 F GonMes Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.358E-7 8.747E-6 7.459E-5 3.849E-4 15 437
45 GSM777059 500 Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.440E-7 9.071E-6 7.735E-5 4.082E-4 15 439
46 gudmap developingLowerUrinaryTract P1 bladder B 1000 k2 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.497E-7 9.227E-6 7.868E-5 4.244E-4 14 379
47 GSM538280 500 Myeloid Cells, DC.LC.Sk, MHCII+ CD11b+ CD45+, Skin, avg-2 Immgen.org, GSE15907 2.095E-7 1.263E-5 1.077E-4 5.938E-4 15 452
48 endothelial Top 500 Cluster 2 endothelial Top 500 Cluster 2 Brain Map - Barres 2.601E-7 1.536E-5 1.310E-4 7.374E-4 7 68
49 26Dn Top 500 Cluster 2 26Dn Top 500 Cluster 2 Brain Map - Allen iN 2.923E-7 1.689E-5 1.440E-4 8.288E-4 9 140
50 54Dn SubClass 54Dn 2 Top 500 Cluster 3 54Dn SubClass 54Dn 2 Top 500 Cluster 3 Brain Map - Allen iN 2.979E-7 1.689E-5 1.440E-4 8.446E-4 8 102
Show 45 more annotations

15: Computational [Display Chart] 305 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 321 Genes in module 321 MSigDb: C4 - CM: Cancer Modules 8.928E-7 2.723E-4 1.715E-3 2.723E-4 9 108
2 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 6.909E-6 1.054E-3 6.637E-3 2.107E-3 11 216
3 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 4.046E-5 3.620E-3 2.280E-2 1.234E-2 13 361
4 module 390 Genes in module 390 MSigDb: C4 - CM: Cancer Modules 4.747E-5 3.620E-3 2.280E-2 1.448E-2 3 8
5 module 8 Genes in module 8 MSigDb: C4 - CM: Cancer Modules 1.339E-4 8.167E-3
5.145E-2
4.084E-2 13 406
6 module 3 Genes in module 3 MSigDb: C4 - CM: Cancer Modules 2.493E-4 1.179E-2
7.424E-2
7.604E-2
12 375
7 module 18 Genes in module 18 MSigDb: C4 - CM: Cancer Modules 2.705E-4 1.179E-2
7.424E-2
8.250E-2
13 436
8 module 543 Genes in module 543 MSigDb: C4 - CM: Cancer Modules 5.412E-4 1.947E-2
1.227E-1
1.651E-1
3 17
9 module 17 Genes in module 17 MSigDb: C4 - CM: Cancer Modules 5.746E-4 1.947E-2
1.227E-1
1.752E-1
11 353
10 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 6.789E-4 2.047E-2
1.290E-1
2.071E-1
12 419
11 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 7.383E-4 2.047E-2
1.290E-1
2.252E-1
12 423
12 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 1.011E-3 2.570E-2
1.619E-1
3.084E-1
11 378
13 module 324 Genes in module 324 MSigDb: C4 - CM: Cancer Modules 1.655E-3 3.770E-2
2.375E-1
5.047E-1
6 131
14 GNF2 CDH11 Neighborhood of CDH11 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.731E-3 3.770E-2
2.375E-1
5.279E-1
3 25
15 module 15 Genes in module 15 MSigDb: C4 - CM: Cancer Modules 1.982E-3 4.030E-2
2.538E-1
6.044E-1
10 350
16 module 488 Genes in module 488 MSigDb: C4 - CM: Cancer Modules 2.414E-3 4.602E-2
2.899E-1
7.363E-1
3 28
17 module 105 Genes in module 105 MSigDb: C4 - CM: Cancer Modules 2.687E-3 4.821E-2
3.037E-1
8.195E-1
7 194
Show 12 more annotations

16: MicroRNA [Display Chart] 1152 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GTACTGT,MIR-101:MSigDB GTACTGT,MIR-101:MSigDB MSigDB 3.767E-5 2.874E-2
2.192E-1
4.339E-2 9 242
2 hsa-miR-124:miRecords TarBase hsa-miR-124:miRecords TarBase miRecords_TarBase 6.184E-5 2.874E-2
2.192E-1
7.124E-2
8 200
3 ACCATTT,MIR-522:MSigDB ACCATTT,MIR-522:MSigDB MSigDB 7.485E-5 2.874E-2
2.192E-1
8.622E-2
7 152
4 CAGTATT,MIR-200B:MSigDB CAGTATT,MIR-200B:MSigDB MSigDB 1.666E-4 3.200E-2
2.440E-1
1.920E-1
11 434
5 CAGTATT,MIR-200C:MSigDB CAGTATT,MIR-200C:MSigDB MSigDB 1.666E-4 3.200E-2
2.440E-1
1.920E-1
11 434
6 CAGTATT,MIR-429:MSigDB CAGTATT,MIR-429:MSigDB MSigDB 1.666E-4 3.200E-2
2.440E-1
1.920E-1
11 434
7 miR-200b:PicTar miR-200b:PicTar PicTar 3.069E-4 4.500E-2
3.432E-1
3.535E-1
11 466
8 miR-200c:PicTar miR-200c:PicTar PicTar 3.125E-4 4.500E-2
3.432E-1
3.600E-1
11 467
9 hsa-miR-101:PITA hsa-miR-101:PITA TOP PITA 3.872E-4 4.957E-2
3.780E-1
4.461E-1
11 479
Show 4 more annotations

17: Drug [Display Chart] 19690 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000445091 B-Ms Stitch 1.909E-9 2.922E-5 3.057E-4 3.759E-5 10 114
2 D001622 Betaine CTD 2.968E-9 2.922E-5 3.057E-4 5.843E-5 11 156
3 C059765 amphotericin B, deoxycholate drug combination CTD 6.436E-9 4.028E-5 4.216E-4 1.267E-4 15 365
4 MESH:D015470/C014347-T Leukemia, Myeloid, Acute affected by decitabine CTD Therapeutic 8.184E-9 4.028E-5 4.216E-4 1.611E-4 7 44
5 C487081 belinostat CTD 2.556E-7 1.007E-3 1.053E-2 5.033E-3 14 417
6 D010656 Phenylephrine CTD 3.925E-7 1.200E-3 1.256E-2 7.729E-3 15 500
7 MESH:D015470/D014212-T Leukemia, Myeloid, Acute affected by Tretinoin CTD Therapeutic 4.517E-7 1.200E-3 1.256E-2 8.894E-3 5 26
8 C500085 muraglitazar CTD 4.875E-7 1.200E-3 1.256E-2 9.599E-3 14 440
9 MESH:D015470/C006632-T Leukemia, Myeloid, Acute affected by arsenic trioxide CTD Therapeutic 5.516E-7 1.207E-3 1.263E-2 1.086E-2 5 27
10 C008493 methylselenic acid CTD 1.223E-6 2.409E-3 2.521E-2 2.409E-2 13 407
11 C010063 carbonyl sulfide CTD 1.626E-6 2.911E-3 3.046E-2 3.202E-2 8 134
12 1369 UP Disulfiram [97-77-8]; Up 200; 13.4uM; HL60; HG-U133A Broad Institute CMAP 2.355E-6 3.735E-3 3.908E-2 4.637E-2 9 189
13 CID000128585 MIII Stitch 2.466E-6 3.735E-3 3.908E-2 4.855E-2 5 36
14 D008942 Mitoxantrone CTD 2.752E-6 3.871E-3 4.051E-2
5.419E-2
10 247
15 C430898 AGN 194204 CTD 3.256E-6 4.273E-3 4.472E-2
6.410E-2
8 147
16 CID000001711 AC1L1C2F Stitch 4.877E-6 6.001E-3
6.280E-2
9.602E-2
7 110
17 D016559 Tacrolimus CTD 6.831E-6 7.532E-3
7.883E-2
1.345E-1
11 337
18 D010042 Ouabain CTD 7.338E-6 7.532E-3
7.883E-2
1.445E-1
7 117
19 CID011214849 2 IgY Stitch 7.497E-6 7.532E-3
7.883E-2
1.476E-1
3 7
20 2439 UP Menadione [58-27-5]; Up 200; 23.2uM; HL60; HT HG-U133A Broad Institute CMAP 7.651E-6 7.532E-3
7.883E-2
1.506E-1
8 165
21 1212 UP Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 9.521E-6 8.699E-3
9.104E-2
1.875E-1
8 170
22 C056933 fumonisin B1 CTD 9.720E-6 8.699E-3
9.104E-2
1.914E-1
10 285
23 3243 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.176E-5 1.006E-2
1.053E-1
2.316E-1
8 175
24 D005001 Ethionine CTD 1.236E-5 1.006E-2
1.053E-1
2.434E-1
10 293
25 1555 UP Clonidine hydrochloride [4205-91-8]; Up 200; 15uM; HL60; HG-U133A Broad Institute CMAP 1.278E-5 1.006E-2
1.053E-1
2.516E-1
8 177
26 1640 UP prochlorperazine dimaleate salt; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.386E-5 1.050E-2
1.099E-1
2.730E-1
8 179
27 C576882 1-(2-trifluoromethoxyphenyl)-2-nitroethanone CTD 1.503E-5 1.057E-2
1.106E-1
2.959E-1
8 181
28 5822 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.503E-5 1.057E-2
1.106E-1
2.959E-1
8 181
29 7088 DN pioglitazone HCl; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 1.627E-5 1.075E-2
1.125E-1
3.203E-1
8 183
30 7074 UP MS-275; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 1.692E-5 1.075E-2
1.125E-1
3.332E-1
8 184
31 6901 UP scriptaid; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.692E-5 1.075E-2
1.125E-1
3.332E-1
8 184
32 5396 UP Dequalinium dichloride [522-51-0]; Up 200; 7.6uM; MCF7; HT HG-U133A Broad Institute CMAP 1.902E-5 1.170E-2
1.225E-1
3.745E-1
8 187
33 CID003056507 H 2-71 Stitch 2.536E-5 1.480E-2
1.549E-1
4.994E-1
3 10
34 390 DN retinoic acid; Down 200; 1uM; HL60; HG-U133A Broad Institute CMAP 2.666E-5 1.480E-2
1.549E-1
5.248E-1
8 196
35 D018818 Fenoldopam CTD 2.693E-5 1.480E-2
1.549E-1
5.303E-1
5 58
36 D001553 Benzbromarone CTD 2.706E-5 1.480E-2
1.549E-1
5.328E-1
10 321
37 C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) CTD 2.889E-5 1.500E-2
1.570E-1
5.688E-1
12 468
38 C010313 pseudocumene CTD 2.971E-5 1.500E-2
1.570E-1
5.850E-1
8 199
39 4204 UP Epitiostanol [2363-58-8]; Up 200; 13uM; PC3; HT HG-U133A Broad Institute CMAP 2.971E-5 1.500E-2
1.570E-1
5.850E-1
8 199
40 CID005365816 lycopersene Stitch 3.650E-5 1.741E-2
1.822E-1
7.186E-1
2 2
41 CID000440155 AC1L98S7 Stitch 3.650E-5 1.741E-2
1.822E-1
7.186E-1
2 2
42 D009281 Naphthalenes CTD 3.714E-5 1.741E-2
1.822E-1
7.313E-1
6 102
43 CID000024766 chondroitin sulfate Stitch 4.471E-5 2.047E-2
2.143E-1
8.804E-1
11 413
44 C501413 tesaglitazar CTD 4.970E-5 2.179E-2
2.280E-1
9.786E-1
12 495
45 1791 UP Azaguanine-8 [134-58-7]; Up 200; 26.2uM; PC3; HT HG-U133A Broad Institute CMAP 5.135E-5 2.179E-2
2.280E-1
1.000E0
7 158
46 2338 UP Mebendazole [31431-39-7]; Up 200; 13.6uM; HL60; HT HG-U133A Broad Institute CMAP 5.135E-5 2.179E-2
2.280E-1
1.000E0
7 158
47 D001761 Bleomycin CTD 5.202E-5 2.179E-2
2.280E-1
1.000E0
11 420
48 5439 UP Pyrvinium pamoate [3546-41-6]; Up 200; 3.4uM; MCF7; HT HG-U133A Broad Institute CMAP 5.785E-5 2.373E-2
2.483E-1
1.000E0
7 161
49 CID005288571 AC1NRBPT Stitch 6.016E-5 2.380E-2
2.491E-1
1.000E0
7 162
50 CID000032756 dermatan sulfate Stitch 6.045E-5 2.380E-2
2.491E-1
1.000E0
8 220
Show 45 more annotations

18: Disease [Display Chart] 1869 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C1709246 Non-Neoplastic Disorder DisGeNET BeFree 6.795E-6 1.270E-2
1.030E-1
1.270E-2 14 461
2 umls:C0206728 Plexiform Neurofibroma DisGeNET Curated 3.042E-5 2.131E-2
1.728E-1
5.686E-2
4 25
3 umls:C0011334 Dental caries DisGeNET Curated 4.454E-5 2.131E-2
1.728E-1
8.325E-2
6 88
4 umls:C0595989 Carcinoma of larynx DisGeNET BeFree 5.253E-5 2.131E-2
1.728E-1
9.818E-2
8 180
5 umls:C0007133 Carcinoma, Papillary DisGeNET BeFree 6.620E-5 2.131E-2
1.728E-1
1.237E-1
8 186
6 umls:C0024667 Animal Mammary Neoplasms DisGeNET Curated 6.840E-5 2.131E-2
1.728E-1
1.278E-1
7 138
7 umls:C0024668 Mammary Neoplasms, Experimental DisGeNET Curated 1.255E-4 3.351E-2
2.718E-1
2.346E-1
7 152
8 umls:C0162534 Prion Diseases DisGeNET Curated 2.061E-4 4.559E-2
3.697E-1
3.852E-1
5 74
9 umls:C1511789 Desmoplastic DisGeNET BeFree 2.195E-4 4.559E-2
3.697E-1
4.103E-1
5 75
Show 4 more annotations