Toppgene analysis for aggregated_1964_log, IC28, negative side

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1: GO: Molecular Function [Display Chart] 296 annotations before applied cutoff / 18819 genes in category

No results to display

2: GO: Biological Process [Display Chart] 1381 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1904293 negative regulation of ERAD pathway 1.910E-5 2.176E-2
1.699E-1
 2.638E-2 3 12
2 GO:1903573 negative regulation of response to endoplasmic reticulum stress 3.151E-5 2.176E-2
1.699E-1
 4.351E-2 4 40
3 GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent 6.053E-5 2.786E-2
2.175E-1
8.359E-2
 2 3

3: GO: Cellular Component [Display Chart] 143 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1990111 spermatoproteasome complex 1.926E-4 2.754E-2
1.527E-1
 2.754E-2 2 5

4: Human Phenotype [Display Chart] 347 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0008843 Hip osteoarthritis 4.347E-4 3.527E-2
2.267E-1
1.508E-1
 2 11
2 HP:0003765 Psoriasis 1.195E-3 3.527E-2
2.267E-1
4.148E-1
 2 18
3 HP:0001426 Multifactorial inheritance 2.093E-3 3.527E-2
2.267E-1
7.262E-1
 3 91
4 HP:0002575 Tracheoesophageal fistula 2.701E-3 3.527E-2
2.267E-1
9.374E-1
 2 27
5 HP:0008142 Delayed calcaneal ossification 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
6 HP:0001248 Short tubular bones of the hand 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
7 HP:0010501 Limitation of knee mobility {has synonym type="layperson"} 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
8 HP:0004591 Disc-like vertebral bodies 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
9 HP:0008857 Neonatal short-trunk short stature 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
10 HP:0000339 Pugilistic facies 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
11 HP:0004180 Short distal phalanx of the 3rd finger 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
12 HP:0200083 Severe limb shortening {has synonym type="layperson"} 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
13 HP:0011382 Hypoplasia of the semicircular canal 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
14 HP:0009290 Short distal phalanx of the 4th finger 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
15 HP:0004605 Absent vertebral body mineralization 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
16 HP:0001980 Megaloblastic bone marrow 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
17 HP:0005068 Absent styloid process of ulna 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
18 HP:0011379 Dilated vestibule of the inner ear 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
19 HP:0012230 Rhegmatogenous retinal detachment 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
20 HP:0004619 Lumbar kyphoscoliosis 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
21 HP:0009566 Short distal phalanx of the 2nd finger 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
22 HP:0006172 Flattened, squared-off epiphyses of tubular bones 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
23 HP:0030672 Asteroid hyalosis 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
24 HP:0011860 Metaphyseal dappling 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
25 HP:0011285 Long-segment aganglionic megacolon 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
26 HP:0200003 Splayed epiphyses 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
27 HP:0005451 Decreased cranial base ossification 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
28 HP:0008271 Abnormal cartilage collagen 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
29 HP:0011381 Aplasia of the semicircular canal 2.948E-3 3.527E-2
2.267E-1
1.000E0
 1 1
30 HP:0002032 Esophageal atresia 3.555E-3 3.929E-2
2.525E-1
1.000E0
 2 31
31 HP:0001831 Short toe {has synonym type="layperson"} 4.268E-3 3.929E-2
2.525E-1
1.000E0
 2 34
32 HP:0005716 Lethal skeletal dysplasia 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
33 HP:0008819 Narrow femoral neck 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
34 HP:0004679 Large tarsal bones 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
35 HP:0005042 Irregular, rachitic-like metaphyses 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
36 HP:0100534 Episcleritis 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
37 HP:0100686 Enthesitis 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
38 HP:0006144 Shortening of all proximal phalanges of the fingers 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
39 HP:0004463 Absent brainstem auditory responses 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
40 HP:0007587 Numerous pigmented freckles {has synonym type="layperson"} 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
41 HP:0006069 Severe carpal ossification delay 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
42 HP:0012122 Anterior uveitis 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
43 HP:0006406 Club-shaped proximal femur 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
44 HP:0004327 Abnormality of the vitreous humor 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
45 HP:0007509 Patchy hypo- and hyperpigmentation 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
46 HP:0030041 Schmorl's node 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
47 HP:0006361 Irregular femoral epiphysis 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
48 HP:0006978 Dysmyelinating leukodystrophy 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
49 HP:0012313 Heberden's node 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
50 HP:0030329 Retinal thinning {has synonym type="layperson"} 5.888E-3 3.929E-2
2.525E-1
1.000E0
 1 2
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 1334 annotations before applied cutoff / 9299 genes in category

No results to display

6: Domain [Display Chart] 489 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF12440 MAGE N Pfam 2.586E-6 6.323E-4 4.281E-3 1.265E-3 4 22
2 IPR021072 MAGE N InterPro 2.586E-6 6.323E-4 4.281E-3 1.265E-3 4 22
3 SM01373 MAGE SMART 1.574E-5 1.618E-3 1.096E-2 7.696E-3 4 34
4 PF01454 MAGE Pfam 1.985E-5 1.618E-3 1.096E-2 9.708E-3 4 36
5 PS50838 MAGE PROSITE 1.985E-5 1.618E-3 1.096E-2 9.708E-3 4 36
6 IPR002190 MHD dom InterPro 1.985E-5 1.618E-3 1.096E-2 9.708E-3 4 36
7 PF04538 BEX Pfam 3.054E-5 1.867E-3 1.264E-2 1.493E-2 3 14
8 IPR021156 TF A-like/BEX InterPro 3.054E-5 1.867E-3 1.264E-2 1.493E-2 3 14
9 SM01392 MAGE N SMART 9.381E-5 5.097E-3 3.451E-2 4.587E-2 3 20
10 IPR007623 BEX InterPro 1.969E-4 9.629E-3
6.519E-2
9.629E-2
 2 5
11 PF06623 MHC I C Pfam 2.945E-4 1.200E-2
8.125E-2
1.440E-1
 2 6
12 IPR010579 MHC I a C InterPro 2.945E-4 1.200E-2
8.125E-2
1.440E-1
 2 6
13 PF07002 Copine Pfam 7.006E-4 2.447E-2
1.657E-1
3.426E-1
 2 9
14 IPR010734 Copine InterPro 7.006E-4 2.447E-2
1.657E-1
3.426E-1
 2 9
15 IPR000243 Pept T1A subB InterPro 8.733E-4 2.847E-2
1.927E-1
4.270E-1
 2 10
16 PS51476 PROTEASOME BETA 2 PROSITE 1.064E-3 2.891E-2
1.957E-1
5.204E-1
 2 11
17 IPR023333 Proteasome suB-type InterPro 1.064E-3 2.891E-2
1.957E-1
5.204E-1
 2 11
18 PS00854 PROTEASOME BETA 1 PROSITE 1.064E-3 2.891E-2
1.957E-1
5.204E-1
 2 11
19 IPR016050 Proteasome bsu CS InterPro 1.273E-3 3.277E-2
2.219E-1
6.227E-1
 2 12
20 IPR003006 Ig/MHC CS InterPro 2.246E-3 3.322E-2
2.249E-1
1.000E0
 3 58
21 PS00290 IG MHC PROSITE 2.475E-3 3.322E-2
2.249E-1
1.000E0
 3 60
22 IPR019594 Glu/Gly-bd InterPro 2.901E-3 3.322E-2
2.249E-1
1.000E0
 2 18
23 SM00079 PBPe SMART 2.901E-3 3.322E-2
2.249E-1
1.000E0
 2 18
24 PF10613 Lig chan-Glu bd Pfam 2.901E-3 3.322E-2
2.249E-1
1.000E0
 2 18
25 SM00918 Lig chan-Glu bd SMART 2.901E-3 3.322E-2
2.249E-1
1.000E0
 2 18
26 IPR001508 Iono rcpt met InterPro 2.901E-3 3.322E-2
2.249E-1
1.000E0
 2 18
27 IPR001320 Iontro rcpt InterPro 2.901E-3 3.322E-2
2.249E-1
1.000E0
 2 18
28 PF00060 Lig chan Pfam 2.901E-3 3.322E-2
2.249E-1
1.000E0
 2 18
29 PF00227 Proteasome Pfam 3.233E-3 3.322E-2
2.249E-1
1.000E0
 2 19
30 IPR001353 Proteasome sua/b InterPro 3.233E-3 3.322E-2
2.249E-1
1.000E0
 2 19
31 PF00129 MHC I Pfam 3.947E-3 3.322E-2
2.249E-1
1.000E0
 2 21
32 IPR001039 MHC I a a1/a2 InterPro 3.947E-3 3.322E-2
2.249E-1
1.000E0
 2 21
33 PF00530 SRCR Pfam 3.947E-3 3.322E-2
2.249E-1
1.000E0
 2 21
34 IPR015459 MDM2 E3 ligase InterPro 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
35 IPR026850 FANCL C InterPro 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
36 IPR030728 PCDHGC3 InterPro 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
37 IPR029253 CYTL1 InterPro 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
38 PF15811 SVIP Pfam 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
39 IPR030718 Protocadherin-15 InterPro 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
40 IPR028279 FGF13 InterPro 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
41 PF05281 Secretogranin V Pfam 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
42 IPR013287 Claudin12 InterPro 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
43 IPR022342 TNFR 19 InterPro 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
44 IPR031574 LYPD6 InterPro 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
45 IPR010300 CDO 1 InterPro 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
46 IPR031632 SVIP InterPro 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
47 PF09765 WD-3 Pfam 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
48 IPR030360 ATP10D InterPro 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
49 IPR031210 FKBP5 InterPro 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
50 IPR018431 Carbonic anhydrase CA14 InterPro 4.484E-3 3.322E-2
2.249E-1
1.000E0
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 409 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 477124 ER-Phagosome pathway BioSystems: REACTOME 1.420E-4 2.904E-2
1.915E-1
5.809E-2
 4 65
2 198786 Proteasome Degradation BioSystems: WikiPathways 1.420E-4 2.904E-2
1.915E-1
5.809E-2
 4 65
3 477122 Antigen processing-Cross presentation BioSystems: REACTOME 3.326E-4 4.535E-2
2.990E-1
1.361E-1
 4 81

8: Pubmed [Display Chart] 10751 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 22925930:gr Analysis of the processing of seven human tumor antigens by intermediate proteasomes. GeneRIF 3.690E-11 1.984E-7 1.956E-6 3.968E-7 4 5
2 22925930 Analysis of the processing of seven human tumor antigens by intermediate proteasomes. Pubmed 3.690E-11 1.984E-7 1.956E-6 3.968E-7 4 5
3 15772651 The DNA sequence of the human X chromosome. Pubmed 3.095E-8 1.109E-4 1.094E-3 3.328E-4 9 407
4 16221301 Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. Pubmed 7.654E-8 1.629E-4 1.606E-3 8.229E-4 4 24
5 11737038:gr Distribution of HLA-A, B alleles and polymorphisms of TAP and LMP genes in Korean patients with atopic dermatitis. GeneRIF 9.090E-8 1.629E-4 1.606E-3 9.773E-4 3 6
6 11737038 Distribution of HLA-A, B alleles and polymorphisms of TAP and LMP genes in Korean patients with atopic dermatitis. Pubmed 9.090E-8 1.629E-4 1.606E-3 9.773E-4 3 6
7 20864041 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Pubmed 2.564E-7 2.745E-4 2.706E-3 2.757E-3 4 32
8 20512145 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Pubmed 3.804E-7 2.745E-4 2.706E-3 4.090E-3 3 9
9 9459506 Sequence of four new HLA-Cw alleles: a possible role of interallelic recombination. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
10 9686604 Sequence-based typing provides a new look at HLA-C diversity. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
11 26613595 An HLA-C amino-acid variant in addition to HLA-B*27 confers risk for ankylosing spondylitis in the Korean population. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
12 21529441 Expression of proteasome immunosubunit in labial glands of patients with primary Sjogren's syndrome. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
13 17480220:gr Associations between HLA class I alleles and the prevalence of nasopharyngeal carcinoma (NPC) among Tunisians. GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
14 14719207:gr Clinical and genetic aspects of psoriatic arthritis "sine psoriasis". GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
15 12352262:gr Associations between MHC class I and susceptibility to HIV-2 disease progression. GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
16 1419902 Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
17 16439971 Distinct clinical differences between HLA-Cw*0602 positive and negative psoriasis patients--an analysis of 1019 HLA-C- and HLA-B-typed patients. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
18 16439971:gr Distinct clinical differences between HLA-Cw*0602 positive and negative psoriasis patients--an analysis of 1019 HLA-C- and HLA-B-typed patients. GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
19 23536655:gr Epstein-Barr virus negativity among individuals older than 60 years is associated with HLA-C and HLA-Bw4 variants and tonsillectomy. GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
20 22586163 Differential human leucocyte allele association between psoriasis and psoriatic arthritis: a family-based association study. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
21 16224524:gr [Association between LMP2/LMP7 gene polymorphism and the infection of hepatitis B virus]. GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
22 21822304 MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
23 16002717:gr Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination. GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
24 15603879 The contribution of HLA class I antigens in immune status following two doses of rubella vaccination. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
25 15603879:gr The contribution of HLA class I antigens in immune status following two doses of rubella vaccination. GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
26 11772516 Age dependent impact of LMP polymorphisms on TNFalpha-induced apoptosis in human peripheral blood mononuclear cells. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
27 14626512 Distribution of the HLA class I allele in chronic hepatitis C and its association with serum ALT level in chronic hepatitis C. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
28 20492592:gr The association and differentiation of MHC class I polymorphic Alu insertions and HLA-B/Cw alleles in seven Chinese populations. GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
29 3485286 Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
30 17085834 HLA alleles in pre-menopausal breast cancer patients from western India. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
31 9894855 A reliable and efficient high resolution typing method for HLA-C using sequence-based typing. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
32 11772516:gr Age dependent impact of LMP polymorphisms on TNFalpha-induced apoptosis in human peripheral blood mononuclear cells. GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
33 14501803 Association of HLA B*3520, B*1801, and Cw*1507 with HIV-1 infection Maharashtra, India. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
34 21303409:gr LMP2/LMP7 gene variant: a risk factor for intestinal Mycobacterium tuberculosis infection in the Chinese population. GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
35 21985130 HLA polymorphism among Chinese patients with chronic plaque psoriasis: subgroup analysis. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
36 17641165:gr A whole-genome association study of major determinants for host control of HIV-1. GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
37 15603870 Association study of LMP gene polymorphisms in Mexican patients with spondyloarthritis. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
38 18627572 New insights of HLA class I association to Behçet's disease in Portuguese patients. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
39 16396320:gr [The frequency of allelic polymorphism of genes encoding immunoproteasome catalytic subunits in acute coronary syndrome patients]. GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
40 15603870:gr Association study of LMP gene polymorphisms in Mexican patients with spondyloarthritis. GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
41 8773323 Haplotypic association of two new HLA class I alleles: Cw*15052 and B*0706: evolutionary relationships of HLA-Cw*15 alleles. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
42 17597093 A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
43 18596105:gr Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
44 23462218 MHC-driven HIV-1 control on the long run is not systematically determined at early times post-HIV-1 infection. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
45 14501803:gr Association of HLA B*3520, B*1801, and Cw*1507 with HIV-1 infection Maharashtra, India. GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
46 12352262 Associations between MHC class I and susceptibility to HIV-2 disease progression. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
47 21985130:gr HLA polymorphism among Chinese patients with chronic plaque psoriasis: subgroup analysis. GeneRIF 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
48 9234488 The novel HLA-Cw*1802 allele is associated with B*5703 in the Bubi population from Equatorial Guinea. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
49 17480220 Associations between HLA class I alleles and the prevalence of nasopharyngeal carcinoma (NPC) among Tunisians. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
50 10395103 Diversity of HLA-B17 alleles and haplotypes in East Asians and a novel Cw6 allele (Cw*0604) associated with B*5701. Pubmed 2.783E-6 2.745E-4 2.706E-3 2.992E-2 2 2
Show 45 more annotations

9: Interaction [Display Chart] 1950 annotations before applied cutoff / 16534 genes in category

No results to display

10: Cytoband [Display Chart] 75 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Xq22.1-q22.3 Xq22.1-q22.3 9.068E-5 6.801E-3 3.334E-2 6.801E-3 2 6
2 4q12 4q12 3.917E-4 1.469E-2
7.199E-2
 2.938E-2 3 57
3 18p11.31 18p11.31 2.365E-3 2.372E-2
1.163E-1
1.774E-1
 2 29
4 13q12.11-q12.3 13q12.11-q12.3 2.481E-3 2.372E-2
1.163E-1
1.861E-1
 1 1
5 Xq13.1-q28 Xq13.1-q28 2.481E-3 2.372E-2
1.163E-1
1.861E-1
 1 1
6 12q14.3-q15 12q14.3-q15 2.481E-3 2.372E-2
1.163E-1
1.861E-1
 1 1
7 15q13-q14 15q13-q14 2.481E-3 2.372E-2
1.163E-1
1.861E-1
 1 1
8 13q13.3 13q13.3 2.530E-3 2.372E-2
1.163E-1
1.898E-1
 2 30
9 12q13.11 12q13.11 3.242E-3 2.702E-2
1.324E-1
2.431E-1
 2 34
10 6p21.3 6p21.3 3.897E-3 2.922E-2
1.432E-1
2.922E-1
 4 257
11 4q11 4q11 4.956E-3 2.967E-2
1.454E-1
3.717E-1
 1 2
12 Xq21.33-q22.3 Xq21.33-q22.3 4.956E-3 2.967E-2
1.454E-1
3.717E-1
 1 2
13 Xq22.1 Xq22.1 5.143E-3 2.967E-2
1.454E-1
3.858E-1
 2 43
14 3q21-q25 3q21-q25 7.425E-3 3.713E-2
1.820E-1
5.569E-1
 1 3
15 4p16-p15 4p16-p15 7.425E-3 3.713E-2
1.820E-1
5.569E-1
 1 3
Show 10 more annotations

11: Transcription Factor Binding Site [Display Chart] 375 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 65 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1136 MAGE family genenames.org 1.231E-5 8.000E-4 3.808E-3 8.000E-4 4 40
2 1217 Brain expressed X-linked family genenames.org 1.248E-4 4.056E-3 1.931E-2 8.113E-3 2 5
3 829 Copines genenames.org 4.452E-4 9.646E-3 4.591E-2 2.894E-2 2 9

13: Coexpression [Display Chart] 4570 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M4780 Genes down-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.222E-8 1.015E-4 9.144E-4 1.015E-4 12 369
2 M1919 Genes up-regulated in MEF cells (embryonic fibroblast) with double knockout of the translation repressors 4EBP1 [GeneID=1978] and 4EBP2 [GeneID=1979]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.502E-7 3.431E-4 3.090E-3 6.862E-4 11 356
3 M5389 Genes whose expression increases with age in normal kidney. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.182E-6 4.049E-3 3.646E-2 1.454E-2 11 486
4 M5505 Genes down-regulated in basal mammary epithelial cells compared to the luminal ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.544E-6 4.049E-3 3.646E-2 1.619E-2 5 59
5 M2697 Genes down-regulated in NCI-60 panel of cell lines with mutated TP53 [Gene ID=7157]. MSigDB C6: Oncogenic Signatures (v5.1) 1.079E-5 7.141E-3
6.430E-2
 4.931E-2 7 192
6 M2721 Genes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] MCF-7 cells (breast cancer) and long-term adapted for estrogen-independent growth. MSigDB C6: Oncogenic Signatures (v5.1) 1.234E-5 7.141E-3
6.430E-2
5.638E-2
 7 196
7 GSE21546 WT VS SAP1A KO DP THYMOCYTES UP Genes up-regulated in untreated double positive thymocytes: wildtype versus ELK4 [GeneID=2005] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.361E-5 7.141E-3
6.430E-2
6.221E-2
 7 199
8 M5475 Genes down-regulated in comparison of dendritic cells (DC) versus effector memory CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v5.1) 1.361E-5 7.141E-3
6.430E-2
6.221E-2
 7 199
9 GSE34156 NOD2 LIGAND VS TLR1 TLR2 LIGAND 6H TREATED MONOCYTE UP Genes up-regulated in monocytes (6h): muramyl dipeptide [PubChem=11620162] versus M. tuberculosis 19 kDa lipopeptide. MSigDB C7: Immunologic Signatures (v5.1) 1.406E-5 7.141E-3
6.430E-2
6.427E-2
 7 200
10 M15055 Genes differentially expressed in multiple myeloma (MM) patients: comparison of MGUS-like vs PCL-like samples; MGUS=monoclonal gammopathy of undetermined significance, PCL=plasma cell leukemia. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.170E-5 1.397E-2
1.258E-1
1.448E-1
 3 16
11 M5911 Genes up-regulated in response to alpha interferon proteins. MSigDB H: Hallmark Gene Sets (v5.1) 4.058E-5 1.397E-2
1.258E-1
1.854E-1
 5 97
12 M8341 Antigen processing and presentation genes down-regulated in JY cells (B lymphocytes) treated with trichostatin A (TSA) [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.128E-5 1.397E-2
1.258E-1
1.886E-1
 4 49
13 M16033 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 8. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.128E-5 1.397E-2
1.258E-1
1.886E-1
 4 49
14 M18441 Genes down-regulated in samples with systolic heart failure compared to normal hearts. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.642E-5 1.397E-2
1.258E-1
2.121E-1
 7 241
15 M14228 Cluster a: genes identifying an intrinsic group in head and neck squamous cell carcinoma (HNSCC). MSigDB C2: CGP Curated Gene Sets (v5.1) 4.697E-5 1.397E-2
1.258E-1
2.146E-1
 5 100
16 M2128 Genes up-regulated in growing IMR90 cells (fibroblast) after knockdown of RB1 [GeneID=5925] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.891E-5 1.397E-2
1.258E-1
2.235E-1
 7 243
17 M1796 The glioblastoma multiforme (GBM) plasticity signature: genes up-regulated in neural stem cells (NSC) with double knockout of TP53 and PTEN [GeneID=7157;5728] vs those with knockout of TP53 alone. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.850E-5 1.573E-2
1.416E-1
2.674E-1
 7 250
18 M1887 Genes up-regulated in gastric mucosal tissue of mice on 2% cholesterol [PubChem=5997] diet and infected with H. pylori vs those infected with H. pylori while on 0% cholesterol diet. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.046E-5 1.737E-2
1.564E-1
3.677E-1
 4 58
19 M2786 Genes down-regulated upon knockdown of PTEN [Gene ID=5728] by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 9.071E-5 1.737E-2
1.564E-1
4.146E-1
 6 185
20 M1184 Genes up-regulated in MCF7 cells (breast cancer, normal TP53 [GeneID=7157]) undergoing aberrant mitosis and necrosis after treatment wiht 4 nM docetaxel [PubChem=148124]. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.826E-5 1.737E-2
1.564E-1
4.490E-1
 3 23
21 M1182 Genes up-regulated in cells expressing MEN1 [GeneID=4221]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.120E-4 1.737E-2
1.564E-1
5.117E-1
 3 24
22 GSE37301 LYMPHOID PRIMED MPP VS CD4 TCELL UP Genes up-regulated in lymphoid primed multipotent progenitors versus CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v5.1) 1.211E-4 1.737E-2
1.564E-1
5.534E-1
 6 195
23 M1350 Genes up-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 48 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.260E-4 1.737E-2
1.564E-1
5.760E-1
 9 487
24 GSE41978 ID2 KO VS BIM KO KLRG1 LOW EFFECTOR CD8 TCELL UP Genes up-regulated in KLRG1 low [GeneID=10219] CD8 T effector cells during infection: ID2 [GeneID=10219] knockout versus BCL2L11 [GeneID=10018] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.353E-4 1.737E-2
1.564E-1
6.183E-1
 6 199
25 GSE41867 DAY6 EFFECTOR VS DAY30 EXHAUSTED CD8 TCELL LCMV CLONE13 UP Genes up-regulated in CD8 T cells during chronic infection with LCMV-Clone 13: effectors at day 6 versus exhausted at day 30. MSigDB C7: Immunologic Signatures (v5.1) 1.353E-4 1.737E-2
1.564E-1
6.183E-1
 6 199
26 M3288 Genes down-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) versus PBMC 7 days after stimulation with YF17D vaccine. MSigDB C7: Immunologic Signatures (v5.1) 1.390E-4 1.737E-2
1.564E-1
6.354E-1
 6 200
27 GSE40274 CTRL VS FOXP3 TRANSDUCED ACTIVATED CD4 TCELL DN Genes down-regulated in CD4 T conv: control versus over-expression of FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v5.1) 1.390E-4 1.737E-2
1.564E-1
6.354E-1
 6 200
28 GSE39556 CD8A DC VS NK CELL UP Genes up-regulated in CD8A [GeneID=925] dendritic cells versus NK cells. MSigDB C7: Immunologic Signatures (v5.1) 1.390E-4 1.737E-2
1.564E-1
6.354E-1
 6 200
29 GSE42021 CD24HI VS CD24INT TREG THYMUS DN Genes down-regulated in thymic T reg: CD24 high [GeneID=100133941] versus CD24 int [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v5.1) 1.390E-4 1.737E-2
1.564E-1
6.354E-1
 6 200
30 M5037 Genes down-regulated in comparison of SP3 thymocytes versus SP4 thymocytes. MSigDB C7: Immunologic Signatures (v5.1) 1.390E-4 1.737E-2
1.564E-1
6.354E-1
 6 200
31 M4720 Genes down-regulated in comparison of dendritic cells (DC) stimulated with R848 at 8 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 8 h. MSigDB C7: Immunologic Signatures (v5.1) 1.390E-4 1.737E-2
1.564E-1
6.354E-1
 6 200
32 GSE37533 PPARG1 FOXP3 VS FOXP3 TRANSDUCED CD4 TCELL PIOGLITAZONE TREATED UP Genes up-regulated in CD4 [GeneID=920] T cells treated with pioglitazone [PubChem=4829] and over-expressing: FOXP3 [GeneID=50943] and PPARg1 isoform of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v5.1) 1.390E-4 1.737E-2
1.564E-1
6.354E-1
 6 200
33 GSE33162 HDAC3 KO VS HDAC3 KO MACROPHAGE UP Genes up-regulated in macrophages with knockout of HDAC3 [GeneID=8841]: heterozygous versus homozygous. MSigDB C7: Immunologic Signatures (v5.1) 1.390E-4 1.737E-2
1.564E-1
6.354E-1
 6 200
34 GSE21670 UNTREATED VS TGFB TREATED CD4 TCELL DN Genes down-regulated in CD4 [GeneID=920] T cells: medium versus TGF beta. MSigDB C7: Immunologic Signatures (v5.1) 1.390E-4 1.737E-2
1.564E-1
6.354E-1
 6 200
35 M3866 Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 8 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 8 h. MSigDB C7: Immunologic Signatures (v5.1) 1.390E-4 1.737E-2
1.564E-1
6.354E-1
 6 200
36 GSE42021 TREG PLN VS CD24INT TREG THYMUS DN Genes down-regulated in T reg: peripheral lymph nodes versus thymic CD24 int [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v5.1) 1.390E-4 1.737E-2
1.564E-1
6.354E-1
 6 200
37 M15887 Genes up-regulated in adipose tissue mesenchymal stem cells (ASC) vs bone marrow mesenchymal stem cells (rBMSC) MSigDB C2: CGP Curated Gene Sets (v5.1) 1.406E-4 1.737E-2
1.564E-1
6.428E-1
 5 126
38 M1466 Genes up-regulated in MEF cells (embryonic fibroblast) expressing ~25% of YY1 [GeneID=7528]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.007E-4 2.414E-2
2.174E-1
9.174E-1
 6 214
39 M5536 Genes up-regulated and displaying increased copy number in glioblastoma samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.191E-4 2.567E-2
2.312E-1
1.000E0
 4 75
40 M2700 Genes down-regulated in bone relapse of breast cancer. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.399E-4 2.661E-2
2.396E-1
1.000E0
 7 314
41 M4551 Genes up-regulated in five primary endothelial cell types (lung, aortic, iliac, dermal, and colon) by IFNG [GeneID=3458]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.425E-4 2.661E-2
2.396E-1
1.000E0
 4 77
42 M15107 Genes up-regulated in CD133+ [GeneID=8842] cells (hematopoietic stem cells, HSC) compared to the CD133- cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.446E-4 2.661E-2
2.396E-1
1.000E0
 7 315
43 M2351 Genes down-regulated in leukemic progenitor cells expressing activated fusion of ESWR1 and FLI1 [GeneID=2130, 2313] compared to normal hematopoetic progenitors. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.742E-4 2.914E-2
2.624E-1
1.000E0
 7 321
44 M17466 Genes up-regulated in five primary endothelial cell types (lung, aortic, iliac, dermal, and colon) by TNF [GeneID=7124]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.234E-4 3.359E-2
3.025E-1
1.000E0
 4 83
45 M11581 Genes up-regulated in pilocytic astrocytoma compared to glioblastoma samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.510E-4 3.564E-2
3.209E-1
1.000E0
 3 35
46 M5301 Genes up-regulated in PC3 cells (prostate cancer) after EZH2 [GeneID=2146] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.965E-4 3.939E-2
3.547E-1
1.000E0
 6 243
47 M4680 Genes up-regulated in RD cells (embryonal rhabdomyosarcoma, ERMS) by expression of PAX3- or PAX7-FOXO1 [GeneID=5077;5081;2308] fusions off retroviral vectors. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.115E-4 4.973E-2
4.478E-1
1.000E0
 6 255
Show 42 more annotations

14: Coexpression Atlas [Display Chart] 2274 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap kidney adult RenalCapsule k4 500 kidney adult RenalCapsule k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.384E-12 9.970E-9 8.281E-8 9.970E-9 9 64
2 gudmap kidney adult RenMedVasc Tie2 k4 200 kidney adult RenMedVasc Tie2 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.474E-11 6.224E-8 5.170E-7 1.245E-7 7 33
3 gudmap kidney adult GlomCapSys Tie2 k4 200 kidney adult GlomCapSys Tie2 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.757E-9 2.848E-6 2.366E-5 8.543E-6 6 33
4 gudmap kidney adult Mesangium Meis 500 kidney adult Mesangium Meis top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.779E-8 8.634E-6 7.172E-5 4.044E-5 13 429
5 gudmap kidney adult CortVasc Tie2 k2 500 kidney adult CortVasc Tie2 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.435E-8 8.634E-6 7.172E-5 5.537E-5 7 76
6 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 500 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.461E-8 8.634E-6 7.172E-5 5.597E-5 13 441
7 gudmap kidney adult Mesangium Meis k1 200 kidney adult Mesangium Meis k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.658E-8 8.634E-6 7.172E-5 6.044E-5 6 45
8 gudmap kidney adult RenMedVasc Tie2 200 kidney adult RenMedVasc Tie2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.281E-8 9.327E-6 7.748E-5 7.462E-5 9 172
9 Facebase RNAseq e8.5 Non-Floor Plate Neural Epithelium 500 FacebaseRNAseq e8.5 Non-Floor Plate Neural Epithelium top-relative-expression-ranked 500 FaceBase_RNAseq 8.218E-8 1.992E-5 1.655E-4 1.869E-4 13 489
10 gudmap kidney adult Mesangium Meis k3 500 kidney adult Mesangium Meis k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.516E-8 1.992E-5 1.655E-4 2.164E-4 8 139
11 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.638E-8 1.992E-5 1.655E-4 2.192E-4 12 410
12 gudmap kidney adult RenMedVasc Tie2 500 kidney adult RenMedVasc Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.158E-7 2.194E-5 1.822E-4 2.632E-4 12 417
13 gudmap kidney adult GlomCapSys Tie2 500 kidney adult GlomCapSys Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.495E-7 2.615E-5 2.172E-4 3.399E-4 12 427
14 gudmap kidney adult RenCorpuscGlomer 500 kidney adult RenCorpuscGlomer top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.965E-7 3.191E-5 2.651E-4 4.468E-4 12 438
15 gudmap kidney adult Mesangium Meis 200 kidney adult Mesangium Meis top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.904E-7 5.918E-5 4.916E-4 8.877E-4 8 167
16 gudmap kidney adult CortVasc Tie2 k4 100 kidney adult CortVasc Tie2 k-means-cluster#4 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 4.405E-7 6.261E-5 5.200E-4 1.002E-3 4 16
17 gudmap kidney adult GlomCapSys Tie2 200 kidney adult GlomCapSys Tie2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.108E-7 6.832E-5 5.675E-4 1.161E-3 8 173
18 gudmap kidney adult Mesangium Meis k4 1000 kidney adult Mesangium Meis k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.023E-6 1.292E-4 1.073E-3 2.326E-3 9 258
19 gudmap kidney adult RenalCapsule k1 200 kidney adult RenalCapsule k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.426E-6 1.597E-4 1.326E-3 3.243E-3 4 21
20 gudmap kidney adult GlomCapSys Tie2 k3 500 kidney adult GlomCapSys Tie2 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.439E-6 1.597E-4 1.326E-3 3.272E-3 6 87
21 gudmap kidney adult CortVasc Tie2 k4 1000 kidney adult CortVasc Tie2 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.475E-6 1.597E-4 1.326E-3 3.353E-3 7 138
22 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k4 1000 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.952E-6 2.017E-4 1.676E-3 4.438E-3 9 279
23 Facebase RNAseq e9.5 Maxillary Arch 500 FacebaseRNAseq e9.5 Maxillary Arch top-relative-expression-ranked 500 FaceBase_RNAseq 4.041E-6 3.995E-4 3.319E-3 9.189E-3 11 484
24 gudmap kidney adult CortVasc Tie2 200 kidney adult CortVasc Tie2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.466E-6 4.143E-4 3.441E-3 1.016E-2 7 163
25 OPC Top 500 All OPC Top 500 All Brain Map - Barres 4.909E-6 4.143E-4 3.441E-3 1.116E-2 11 494
26 26Dp Top 500 All 26Dp Top 500 All Brain Map - Allen iN 5.004E-6 4.143E-4 3.441E-3 1.138E-2 11 495
27 Facebase RNAseq e10.5 Olfactory Pit 500 FacebaseRNAseq e10.5 Olfactory Pit top-relative-expression-ranked 500 FaceBase_RNAseq 5.004E-6 4.143E-4 3.441E-3 1.138E-2 11 495
28 Facebase RNAseq e8.5 Hind Brain Neural Epithelium 500 FacebaseRNAseq e8.5 Hind Brain Neural Epithelium top-relative-expression-ranked 500 FaceBase_RNAseq 5.101E-6 4.143E-4 3.441E-3 1.160E-2 11 496
29 gudmap kidney adult RenCorpuscGlomer k1 200 kidney adult RenCorpuscGlomer k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 6.352E-6 4.981E-4 4.137E-3 1.444E-2 4 30
30 gudmap kidney adult CortVasc Tie2 500 kidney adult CortVasc Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.333E-6 5.498E-4 4.567E-3 1.668E-2 10 418
31 Facebase RNAseq e8.5 Non-Floor Plate Neural Epithelium 1000 K2 FacebaseRNAseq e8.5 Non-Floor Plate Neural Epithelium top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 7.495E-6 5.498E-4 4.567E-3 1.704E-2 8 248
32 PCBC ratio MESO-5 amniotic fluid MSC vs MESO-5 blastocyst cfr-2X-p05 MESO-5 amniotic fluid MSC vs MESO-5 blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 8.305E-6 5.902E-4 4.902E-3 1.888E-2 10 424
33 facebase RNAseq e10.5 MaxArch 2500 K0 facebase RNAseq e10.5 MaxArch 2500 K0 Gudmap RNAseq 1.029E-5 7.089E-4 5.889E-3 2.339E-2 6 122
34 gudmap kidney adult CortVasc Tie2 100 kidney adult CortVasc Tie2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.525E-5 1.020E-3 8.472E-3 3.468E-2 5 77
35 mendel RNAseq e18.5 Urothelium Krt5CreRFP 2500 K3 mendel RNAseq e18.5 Urothelium Krt5CreRFP 2500 K3 Gudmap RNAseq 1.993E-5 1.295E-3 1.076E-2 4.532E-2 6 137
36 gudmap kidney adult GlomCapSys Tie2 100 kidney adult GlomCapSys Tie2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 2.073E-5 1.309E-3 1.088E-2 4.713E-2 5 82
37 Facebase RNAseq e10.5 Neural Epithelium Overlying Medial Eminence 500 FacebaseRNAseq e10.5 Neural Epithelium Overlying Medial Eminence top-relative-expression-ranked 500 FaceBase_RNAseq 2.507E-5 1.541E-3 1.280E-2
5.702E-2
 10 482
38 54Dp Top 500 Cluster 0 54Dp Top 500 Cluster 0 Brain Map - Allen iN 2.643E-5 1.541E-3 1.280E-2
6.011E-2
 10 485
39 54Dp Top 500 All 54Dp Top 500 All Brain Map - Allen iN 2.643E-5 1.541E-3 1.280E-2
6.011E-2
 10 485
40 Facebase RNAseq e8.5 Floor Plate 500 FacebaseRNAseq e8.5 Floor Plate top-relative-expression-ranked 500 FaceBase_RNAseq 3.143E-5 1.787E-3 1.484E-2
7.148E-2
 10 495
41 Facebase RNAseq e10.5 Neural Epithelium Overlying Central Eminence 500 FacebaseRNAseq e10.5 Neural Epithelium Overlying Central Eminence top-relative-expression-ranked 500 FaceBase_RNAseq 3.253E-5 1.804E-3 1.499E-2
7.396E-2
 10 497
42 gudmap kidney adult Podocyte MafB k2 500 kidney adult Podocyte MafB k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.923E-5 2.124E-3 1.764E-2
8.921E-2
 4 47
43 facebase RNAseq e8.5 NeuroEpith hindBrain 2500 K2 facebase RNAseq e8.5 NeuroEpith hindBrain 2500 K2 Gudmap RNAseq 4.224E-5 2.234E-3 1.855E-2
9.604E-2
 5 95
44 gudmap kidney adult Mesangium Meis k2 100 kidney adult Mesangium Meis k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 5.939E-5 3.070E-3 2.550E-2
1.351E-1
 3 19
45 ratio SC vs MESO 1000 K3 ratio StemCell vs induced-Mesoderm top-relative-expression-ranked 1000 k-means-cluster#3 PCBC 6.686E-5 3.379E-3 2.807E-2
1.520E-1
 6 170
46 gudmap kidney adult RenCorpuscGlomer 200 kidney adult RenCorpuscGlomer top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 7.133E-5 3.490E-3 2.899E-2
1.622E-1
 6 172
47 neurons Top 500 Cluster 2 neurons Top 500 Cluster 2 Brain Map - Barres 7.318E-5 3.490E-3 2.899E-2
1.664E-1
 4 55
48 Facebase RNAseq e10.5 Maxillary Arch 1000 K2 FacebaseRNAseq e10.5 Maxillary Arch top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 7.366E-5 3.490E-3 2.899E-2
1.675E-1
 6 173
49 gudmap developingLowerUrinaryTract adult ureter 500 k2 DevelopingLowerUrinaryTract adult ureter emap-29479 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.857E-5 3.573E-3 2.968E-2
1.787E-1
 4 56
50 54Dp SubClass 54Dp 1 Top 500 Cluster 4 54Dp SubClass 54Dp 1 Top 500 Cluster 4 Brain Map - Allen iN 7.857E-5 3.573E-3 2.968E-2
1.787E-1
 4 56
Show 45 more annotations

15: Computational [Display Chart] 209 annotations before applied cutoff / 9399 genes in category

No results to display

16: MicroRNA [Display Chart] 946 annotations before applied cutoff / 19844 genes in category

No results to display

17: Drug [Display Chart] 11935 annotations before applied cutoff / 22098 genes in category

No results to display

18: Disease [Display Chart] 1137 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C1519176 Salivary Gland Pleomorphic Adenoma DisGeNET Curated 1.124E-5 1.083E-2
8.248E-2
 1.278E-2 4 32
2 umls:C0032026 Pityriasis Rosea DisGeNET BeFree 1.906E-5 1.083E-2
8.248E-2
 2.167E-2 2 2
3 umls:C1517445 Ganglioneuroblastoma, Nodular DisGeNET BeFree 1.137E-4 3.232E-2
2.460E-1
1.293E-1
 2 4
4 umls:C0011573 Endogenous depression DisGeNET BeFree 1.137E-4 3.232E-2
2.460E-1
1.293E-1
 2 4
5 umls:C1514225 Poorly Differentiated Neuroblastoma DisGeNET BeFree 1.889E-4 3.703E-2
2.819E-1
2.148E-1
 2 5
6 umls:C0235904 Megacolon, not Hirschsprung's DisGeNET BeFree 2.826E-4 3.703E-2
2.819E-1
3.213E-1
 2 6
7 umls:C0033953 Psychosexual Disorders DisGeNET Curated 2.826E-4 3.703E-2
2.819E-1
3.213E-1
 2 6
8 umls:C0017980 Glycosuria, Renal DisGeNET Curated 3.945E-4 3.703E-2
2.819E-1
4.486E-1
 2 7
9 umls:C0011124 Decreased Libido DisGeNET BeFree 3.945E-4 3.703E-2
2.819E-1
4.486E-1
 2 7
10 umls:C0040592 Trachoma DisGeNET BeFree 4.418E-4 3.703E-2
2.819E-1
5.024E-1
 3 34
11 umls:C0025160 Megacolon DisGeNET Curated 5.245E-4 3.703E-2
2.819E-1
5.964E-1
 2 8
12 umls:C0035305 Retinal Detachment DisGeNET Curated 5.683E-4 3.703E-2
2.819E-1
6.462E-1
 3 37
13 umls:C0036877 organic sexual dysfunction DisGeNET BeFree 8.382E-4 3.703E-2
2.819E-1
9.530E-1
 2 10
14 umls:C0275544 Congenital infectious disease DisGeNET BeFree 8.382E-4 3.703E-2
2.819E-1
9.530E-1
 2 10
15 umls:C0260037 Multiple tumors DisGeNET BeFree 8.400E-4 3.703E-2
2.819E-1
9.551E-1
 4 96
16 umls:C1304140 Familial psoriasis DisGeNET BeFree 1.022E-3 3.703E-2
2.819E-1
1.000E0
 2 11
17 umls:C0000735 Abdominal Neoplasms DisGeNET BeFree 1.022E-3 3.703E-2
2.819E-1
1.000E0
 2 11
18 umls:C0920028 Leukaemia recurrent DisGeNET BeFree 1.022E-3 3.703E-2
2.819E-1
1.000E0
 2 11
19 umls:C0242621 Isochromosomes DisGeNET BeFree 1.149E-3 3.703E-2
2.819E-1
1.000E0
 3 47
20 umls:C0543698 Hypersensitive syndrome DisGeNET BeFree 1.222E-3 3.703E-2
2.819E-1
1.000E0
 2 12
21 umls:C0549622 Sexual Dysfunction DisGeNET Curated 1.222E-3 3.703E-2
2.819E-1
1.000E0
 2 12
22 umls:C1333280 Desmoplastic melanoma DisGeNET BeFree 1.441E-3 3.703E-2
2.819E-1
1.000E0
 2 13
23 umls:C1334407 Localized Carcinoma DisGeNET BeFree 1.441E-3 3.703E-2
2.819E-1
1.000E0
 2 13
24 umls:C0796563 Localized Malignant Neoplasm DisGeNET BeFree 1.676E-3 3.703E-2
2.819E-1
1.000E0
 2 14
25 umls:C0034902 Pure Red-Cell Aplasia DisGeNET BeFree 1.676E-3 3.703E-2
2.819E-1
1.000E0
 2 14
26 umls:C0750974 Brain Tumor, Primary DisGeNET BeFree 1.720E-3 3.703E-2
2.819E-1
1.000E0
 3 54
27 umls:C0041755 Adverse reaction to drug DisGeNET Curated 1.720E-3 3.703E-2
2.819E-1
1.000E0
 3 54
28 umls:C0206715 Neoplasms, Neuroepithelial DisGeNET BeFree 1.928E-3 3.703E-2
2.819E-1
1.000E0
 2 15
29 umls:C0017677 Glossitis, Benign Migratory DisGeNET BeFree 2.483E-3 3.703E-2
2.819E-1
1.000E0
 2 17
30 umls:C0038325 Stevens-Johnson Syndrome DisGeNET Curated 2.677E-3 3.703E-2
2.819E-1
1.000E0
 3 63
31 umls:C1337013 Differentiated Thyroid Gland Carcinoma DisGeNET BeFree 2.865E-3 3.703E-2
2.819E-1
1.000E0
 4 134
32 umls:C0409651 Seropositive rheumatoid arthritis DisGeNET BeFree 3.105E-3 3.703E-2
2.819E-1
1.000E0
 2 19
33 umls:C0949691 Spondylarthropathies DisGeNET BeFree 3.326E-3 3.703E-2
2.819E-1
1.000E0
 3 68
34 umls:C0280631 Leiomyosarcoma of uterus DisGeNET BeFree 3.440E-3 3.703E-2
2.819E-1
1.000E0
 2 20
35 cv:C1861028 Tracheoesophageal fistula Clinical Variations 3.791E-3 3.703E-2
2.819E-1
1.000E0
 2 21
36 umls:C0002390 Extrinsic allergic alveolitis DisGeNET Curated 3.791E-3 3.703E-2
2.819E-1
1.000E0
 2 21
37 umls:C0153594 Malignant neoplasm of testis DisGeNET Curated 4.080E-3 3.703E-2
2.819E-1
1.000E0
 5 240
38 umls:C0023891 Liver Cirrhosis, Alcoholic DisGeNET Curated 4.384E-3 3.703E-2
2.819E-1
1.000E0
 3 75
39 umls:C0410480 Avascular Necrosis of Femur Head DisGeNET Curated 4.396E-3 3.703E-2
2.819E-1
1.000E0
 1 1
40 cv:C1836727 Peripheral demyelinating neuropathy, central dysmyelination, Waardenburg syndrome, and Hirschsprung disease Clinical Variations 4.396E-3 3.703E-2
2.819E-1
1.000E0
 1 1
41 cv:C1865885 Usher syndrome, type 1F Clinical Variations 4.396E-3 3.703E-2
2.819E-1
1.000E0
 1 1
42 umls:C1851536 Epiphyseal Dysplasia, Multiple, with Myopia and Conductive Deafness DisGeNET Curated 4.396E-3 3.703E-2
2.819E-1
1.000E0
 1 1
43 611584 WAARDENBURG SYNDROME, TYPE 2E; WS2E OMIM 4.396E-3 3.703E-2
2.819E-1
1.000E0
 1 1
44 cv:C1840547 Abacavir hypersensitivity Clinical Variations 4.396E-3 3.703E-2
2.819E-1
1.000E0
 1 1
45 umls:C1866425 Yemenite deaf-blind hypopigmentation syndrome DisGeNET Curated 4.396E-3 3.703E-2
2.819E-1
1.000E0
 1 1
46 umls:C1858079 Osteoarthritis with Mild Chondrodysplasia DisGeNET Curated 4.396E-3 3.703E-2
2.819E-1
1.000E0
 1 1
47 umls:C2700405 WAARDENBURG SYNDROME, TYPE IIE DisGeNET Curated 4.396E-3 3.703E-2
2.819E-1
1.000E0
 1 1
48 cv:C0038013 Ankylosing spondylitis Clinical Variations 4.396E-3 3.703E-2
2.819E-1
1.000E0
 1 1
49 300699 MENTAL RETARDATION, X-LINKED 94; MRX94 OMIM 4.396E-3 3.703E-2
2.819E-1
1.000E0
 1 1
50 cv:C3280690 Accelerated tumor formation, susceptibility to Clinical Variations 4.396E-3 3.703E-2
2.819E-1
1.000E0
 1 1
Show 45 more annotations