Toppgene analysis for aggregated_1964_log, IC27, positive side

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1: GO: Molecular Function [Display Chart] 851 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0022804 active transmembrane transporter activity 8.018E-5 3.552E-2
2.601E-1
6.823E-2
 15 363
2 GO:0015399 primary active transmembrane transporter activity 1.575E-4 3.552E-2
2.601E-1
1.341E-1
 8 119
3 GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity 1.575E-4 3.552E-2
2.601E-1
1.341E-1
 8 119
4 GO:0001948 glycoprotein binding 1.669E-4 3.552E-2
2.601E-1
1.421E-1
 8 120
5 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor 4.939E-4 4.617E-2
3.382E-1
4.203E-1
 2 3
6 GO:0035373 chondroitin sulfate proteoglycan binding 4.939E-4 4.617E-2
3.382E-1
4.203E-1
 2 3
7 GO:0042626 ATPase activity, coupled to transmembrane movement of substances 5.653E-4 4.617E-2
3.382E-1
4.811E-1
 7 110
8 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 5.708E-4 4.617E-2
3.382E-1
4.857E-1
 4 30
9 GO:0005539 glycosaminoglycan binding 5.783E-4 4.617E-2
3.382E-1
4.922E-1
 10 219
10 GO:1901681 sulfur compound binding 5.889E-4 4.617E-2
3.382E-1
5.011E-1
 11 260
11 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 5.968E-4 4.617E-2
3.382E-1
5.079E-1
 7 111
12 GO:0008191 metalloendopeptidase inhibitor activity 6.967E-4 4.941E-2
3.619E-1
5.929E-1
 3 14
Show 7 more annotations

2: GO: Biological Process [Display Chart] 4047 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0050804 modulation of synaptic transmission 9.820E-9 3.974E-5 3.530E-4 3.974E-5 21 358
2 GO:0051961 negative regulation of nervous system development 1.417E-7 2.867E-4 2.547E-3 5.734E-4 18 311
3 GO:0050806 positive regulation of synaptic transmission 7.718E-7 6.763E-4 6.007E-3 3.124E-3 12 153
4 GO:0048771 tissue remodeling 8.275E-7 6.763E-4 6.007E-3 3.349E-3 13 183
5 GO:0042063 gliogenesis 9.281E-7 6.763E-4 6.007E-3 3.756E-3 16 282
6 GO:0010721 negative regulation of cell development 1.025E-6 6.763E-4 6.007E-3 4.147E-3 18 356
7 GO:0050768 negative regulation of neurogenesis 1.170E-6 6.763E-4 6.007E-3 4.734E-3 16 287
8 GO:0001504 neurotransmitter uptake 1.339E-6 6.774E-4 6.017E-3 5.419E-3 6 28
9 GO:0050808 synapse organization 1.744E-6 7.843E-4 6.967E-3 7.059E-3 15 261
10 GO:0010975 regulation of neuron projection development 2.098E-6 8.489E-4 7.541E-3 8.489E-3 21 494
11 GO:0007611 learning or memory 2.904E-6 1.068E-3 9.490E-3 1.175E-2 15 272
12 GO:0030198 extracellular matrix organization 4.119E-6 1.213E-3 1.078E-2 1.667E-2 17 354
13 GO:0043062 extracellular structure organization 4.276E-6 1.213E-3 1.078E-2 1.731E-2 17 355
14 GO:0050673 epithelial cell proliferation 4.286E-6 1.213E-3 1.078E-2 1.734E-2 18 394
15 GO:0010001 glial cell differentiation 4.497E-6 1.213E-3 1.078E-2 1.820E-2 13 213
16 GO:0042493 response to drug 5.149E-6 1.302E-3 1.157E-2 2.084E-2 20 481
17 GO:0034405 response to fluid shear stress 7.493E-6 1.784E-3 1.585E-2 3.032E-2 6 37
18 GO:0045665 negative regulation of neuron differentiation 9.406E-6 2.011E-3 1.786E-2 3.807E-2 13 228
19 GO:0045666 positive regulation of neuron differentiation 9.441E-6 2.011E-3 1.786E-2 3.821E-2 17 377
20 GO:0051966 regulation of synaptic transmission, glutamatergic 1.099E-5 2.143E-3 1.904E-2 4.446E-2 7 59
21 GO:0050890 cognition 1.112E-5 2.143E-3 1.904E-2 4.501E-2 15 304
22 GO:0050769 positive regulation of neurogenesis 1.212E-5 2.229E-3 1.980E-2 4.905E-2 19 467
23 GO:0050803 regulation of synapse structure or activity 1.484E-5 2.611E-3 2.319E-2
6.005E-2
 14 274
24 GO:0031345 negative regulation of cell projection organization 2.309E-5 3.893E-3 3.458E-2
9.344E-2
 11 179
25 GO:0050678 regulation of epithelial cell proliferation 2.524E-5 4.086E-3 3.629E-2
1.021E-1
 15 326
26 GO:0010977 negative regulation of neuron projection development 3.041E-5 4.734E-3 4.205E-2
1.231E-1
 10 152
27 GO:0007409 axonogenesis 5.665E-5 8.491E-3
7.543E-2
2.293E-1
 18 478
28 GO:0035690 cellular response to drug 6.902E-5 9.662E-3
8.583E-2
2.793E-1
 7 78
29 GO:0098657 import into cell 6.923E-5 9.662E-3
8.583E-2
2.802E-1
 6 54
30 GO:0070459 prolactin secretion 7.290E-5 9.834E-3
8.736E-2
2.950E-1
 3 7
31 GO:0042698 ovulation cycle 8.597E-5 1.065E-2
9.456E-2
3.479E-1
 9 139
32 GO:0001503 ossification 8.693E-5 1.065E-2
9.456E-2
3.518E-1
 16 406
33 GO:0045860 positive regulation of protein kinase activity 9.065E-5 1.065E-2
9.456E-2
3.668E-1
 18 496
34 GO:0045780 positive regulation of bone resorption 9.233E-5 1.065E-2
9.456E-2
3.737E-1
 4 19
35 GO:0046852 positive regulation of bone remodeling 9.233E-5 1.065E-2
9.456E-2
3.737E-1
 4 19
36 GO:0010634 positive regulation of epithelial cell migration 9.469E-5 1.065E-2
9.456E-2
3.832E-1
 8 110
37 GO:0031346 positive regulation of cell projection organization 9.970E-5 1.065E-2
9.457E-2
4.035E-1
 15 368
38 GO:0010632 regulation of epithelial cell migration 9.996E-5 1.065E-2
9.457E-2
4.045E-1
 10 175
39 GO:0035249 synaptic transmission, glutamatergic 1.027E-4 1.065E-2
9.465E-2
4.155E-1
 7 83
40 GO:0008038 neuron recognition 1.102E-4 1.115E-2
9.901E-2
4.458E-1
 5 37
41 GO:0010769 regulation of cell morphogenesis involved in differentiation 1.227E-4 1.211E-2
1.076E-1
4.967E-1
 15 375
42 GO:0008360 regulation of cell shape 1.390E-4 1.315E-2
1.168E-1
5.624E-1
 9 148
43 GO:0007413 axonal fasciculation 1.397E-4 1.315E-2
1.168E-1
5.653E-1
 4 21
44 GO:0007416 synapse assembly 1.463E-4 1.345E-2
1.195E-1
5.919E-1
 9 149
45 GO:0021782 glial cell development 1.595E-4 1.425E-2
1.266E-1
6.456E-1
 7 89
46 GO:1902722 positive regulation of prolactin secretion 1.680E-4 1.425E-2
1.266E-1
6.800E-1
 2 2
47 GO:0043090 amino acid import 1.690E-4 1.425E-2
1.266E-1
6.839E-1
 4 22
48 GO:0031290 retinal ganglion cell axon guidance 1.690E-4 1.425E-2
1.266E-1
6.839E-1
 4 22
49 GO:0030031 cell projection assembly 2.019E-4 1.668E-2
1.482E-1
8.172E-1
 16 437
50 GO:0046849 bone remodeling 2.396E-4 1.854E-2
1.647E-1
9.695E-1
 7 95
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 406 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0044420 extracellular matrix component 4.069E-8 1.652E-5 1.088E-4 1.652E-5 13 143
2 GO:0005604 basement membrane 1.899E-7 3.856E-5 2.539E-4 7.712E-5 11 111
3 GO:0031012 extracellular matrix 3.113E-7 4.213E-5 2.774E-4 1.264E-4 21 444
4 GO:0005578 proteinaceous extracellular matrix 4.846E-7 4.918E-5 3.239E-4 1.967E-4 19 379
5 GO:0098794 postsynapse 1.805E-6 1.465E-4 9.649E-4 7.326E-4 20 454
6 GO:0097386 glial cell projection 2.496E-6 1.689E-4 1.112E-3 1.014E-3 5 18
7 GO:0097449 astrocyte projection 1.727E-5 1.002E-3 6.595E-3 7.011E-3 4 13
8 GO:0043235 receptor complex 3.455E-5 1.604E-3 1.056E-2 1.403E-2 15 339
9 GO:0098857 membrane microdomain 3.951E-5 1.604E-3 1.056E-2 1.604E-2 15 343
10 GO:0045121 membrane raft 3.951E-5 1.604E-3 1.056E-2 1.604E-2 15 343
11 GO:0005912 adherens junction 5.707E-5 2.106E-3 1.387E-2 2.317E-2 18 484
12 GO:0030055 cell-substrate junction 6.936E-5 2.334E-3 1.537E-2 2.816E-2 16 403
13 GO:0098858 actin-based cell projection 7.472E-5 2.334E-3 1.537E-2 3.034E-2 11 206
14 GO:0031594 neuromuscular junction 1.292E-4 3.583E-3 2.359E-2
5.246E-2
 6 61
15 GO:0060076 excitatory synapse 1.324E-4 3.583E-3 2.359E-2
5.374E-2
 12 258
16 GO:0031252 cell leading edge 1.608E-4 4.081E-3 2.687E-2
6.529E-2
 15 389
17 GO:0005924 cell-substrate adherens junction 2.060E-4 4.919E-3 3.239E-2
8.362E-2
 15 398
18 GO:0099572 postsynaptic specialization 2.653E-4 5.670E-3 3.733E-2
1.077E-1
 11 238
19 GO:0014069 postsynaptic density 2.653E-4 5.670E-3 3.733E-2
1.077E-1
 11 238
20 GO:0005771 multivesicular body 2.980E-4 6.049E-3 3.983E-2
1.210E-1
 5 46
21 GO:0016323 basolateral plasma membrane 3.398E-4 6.570E-3 4.326E-2
1.380E-1
 11 245
22 GO:0005925 focal adhesion 5.851E-4 1.080E-2
7.110E-2
2.376E-1
 14 393
23 GO:0005769 early endosome 7.816E-4 1.331E-2
8.764E-2
3.173E-1
 12 314
24 GO:0043197 dendritic spine 7.867E-4 1.331E-2
8.764E-2
3.194E-1
 8 152
25 GO:0044309 neuron spine 8.567E-4 1.391E-2
9.162E-2
3.478E-1
 8 154
26 GO:0005614 interstitial matrix 1.033E-3 1.613E-2
1.062E-1
4.193E-1
 3 16
27 GO:0045177 apical part of cell 1.357E-3 2.040E-2
1.344E-1
5.509E-1
 14 429
28 GO:0001726 ruffle 1.556E-3 2.203E-2
1.451E-1
6.317E-1
 8 169
29 GO:0097450 astrocyte end-foot 1.598E-3 2.203E-2
1.451E-1
6.490E-1
 2 5
30 GO:0034358 plasma lipoprotein particle 1.682E-3 2.203E-2
1.451E-1
6.829E-1
 4 40
31 GO:1990777 lipoprotein particle 1.682E-3 2.203E-2
1.451E-1
6.829E-1
 4 40
32 GO:0032994 protein-lipid complex 2.019E-3 2.494E-2
1.642E-1
8.198E-1
 4 42
33 GO:0030175 filopodium 2.027E-3 2.494E-2
1.642E-1
8.229E-1
 6 102
34 GO:0098802 plasma membrane receptor complex 2.310E-3 2.758E-2
1.816E-1
9.379E-1
 8 180
35 GO:0030139 endocytic vesicle 2.378E-3 2.758E-2
1.816E-1
9.654E-1
 10 266
36 GO:0030426 growth cone 2.474E-3 2.790E-2
1.837E-1
1.000E0
 8 182
37 GO:0031983 vesicle lumen 2.703E-3 2.966E-2
1.953E-1
1.000E0
 6 108
38 GO:0030427 site of polarized growth 2.922E-3 3.122E-2
2.056E-1
1.000E0
 8 187
39 GO:0005911 cell-cell junction 3.150E-3 3.190E-2
2.101E-1
1.000E0
 13 420
40 GO:0031256 leading edge membrane 3.275E-3 3.190E-2
2.101E-1
1.000E0
 7 150
41 GO:0098642 network-forming collagen trimer 3.300E-3 3.190E-2
2.101E-1
1.000E0
 2 7
42 GO:0098645 collagen network 3.300E-3 3.190E-2
2.101E-1
1.000E0
 2 7
43 GO:0031901 early endosome membrane 3.536E-3 3.339E-2
2.199E-1
1.000E0
 6 114
44 GO:0030666 endocytic vesicle membrane 4.208E-3 3.690E-2
2.430E-1
1.000E0
 7 157
45 GO:0031253 cell projection membrane 4.239E-3 3.690E-2
2.430E-1
1.000E0
 11 336
46 GO:1990712 HFE-transferrin receptor complex 4.363E-3 3.690E-2
2.430E-1
1.000E0
 2 8
47 GO:0034366 spherical high-density lipoprotein particle 4.363E-3 3.690E-2
2.430E-1
1.000E0
 2 8
48 GO:0098651 basement membrane collagen trimer 4.363E-3 3.690E-2
2.430E-1
1.000E0
 2 8
49 GO:0016328 lateral plasma membrane 4.734E-3 3.866E-2
2.546E-1
1.000E0
 4 53
50 GO:0034774 secretory granule lumen 4.762E-3 3.866E-2
2.546E-1
1.000E0
 5 85
Show 45 more annotations

4: Human Phenotype [Display Chart] 843 annotations before applied cutoff / 4410 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 3536 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0005023 abnormal wound healing 2.471E-5 3.292E-2
2.879E-1
8.737E-2
 14 201
2 MP:0000249 abnormal blood vessel physiology 2.732E-5 3.292E-2
2.879E-1
9.661E-2
 21 410
3 MP:0005595 abnormal vascular smooth muscle physiology 2.986E-5 3.292E-2
2.879E-1
1.056E-1
 12 153
4 MP:0004883 abnormal vascular wound healing 4.215E-5 3.292E-2
2.879E-1
1.490E-1
 8 69
5 MP:0003690 abnormal glial cell physiology 4.654E-5 3.292E-2
2.879E-1
1.646E-1
 10 112
6 MP:0010053 decreased grip strength 6.728E-5 3.965E-2
3.468E-1
2.379E-1
 16 278
7 MP:0003634 abnormal glial cell morphology 8.784E-5 4.437E-2
3.882E-1
3.106E-1
 20 411
Show 2 more annotations

6: Domain [Display Chart] 1623 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00041 fn3 Pfam 9.261E-6 8.685E-3
6.921E-2
 1.503E-2 11 162
2 IPR003961 FN3 dom InterPro 1.991E-5 8.685E-3
6.921E-2
 3.232E-2 12 209
3 PF09289 FOLN Pfam 2.140E-5 8.685E-3
6.921E-2
 3.474E-2 3 5
4 IPR015369 Follistatin/Osteonectin EGF InterPro 2.140E-5 8.685E-3
6.921E-2
 3.474E-2 3 5
5 SM00060 FN3 SMART 3.208E-5 1.041E-2
8.299E-2
5.207E-2
 11 185
6 PS50853 FN3 PROSITE 6.237E-5 1.687E-2
1.345E-1
1.012E-1
 11 199
7 PS00612 OSTEONECTIN 1 PROSITE 1.689E-4 2.552E-2
2.034E-1
2.742E-1
 2 2
8 PS00613 OSTEONECTIN 2 PROSITE 1.689E-4 2.552E-2
2.034E-1
2.742E-1
 2 2
9 IPR001999 Osteonectin CS InterPro 1.689E-4 2.552E-2
2.034E-1
2.742E-1
 2 2
10 PF07002 Copine Pfam 1.730E-4 2.552E-2
2.034E-1
2.807E-1
 3 9
11 IPR010734 Copine InterPro 1.730E-4 2.552E-2
2.034E-1
2.807E-1
 3 9
12 SM00274 FOLN SMART 3.333E-4 4.161E-2
3.316E-1
5.409E-1
 3 11
13 IPR003645 Fol N InterPro 3.333E-4 4.161E-2
3.316E-1
5.409E-1
 3 11
14 IPR018237 Myelin PLP CS InterPro 5.024E-4 4.292E-2
3.420E-1
8.154E-1
 2 3
15 PS01004 MYELIN PLP 2 PROSITE 5.024E-4 4.292E-2
3.420E-1
8.154E-1
 2 3
16 SM00002 PLP SMART 5.024E-4 4.292E-2
3.420E-1
8.154E-1
 2 3
17 PF01275 Myelin PLP Pfam 5.024E-4 4.292E-2
3.420E-1
8.154E-1
 2 3
18 PS00575 MYELIN PLP 1 PROSITE 5.024E-4 4.292E-2
3.420E-1
8.154E-1
 2 3
19 IPR001614 Myelin PLP InterPro 5.024E-4 4.292E-2
3.420E-1
8.154E-1
 2 3
20 IPR019819 Carboxylesterase B CS InterPro 5.666E-4 4.598E-2
3.665E-1
9.196E-1
 3 13
Show 15 more annotations

7: Pathway [Display Chart] 1253 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 576262 Extracellular matrix organization BioSystems: REACTOME 1.003E-5 1.257E-2
9.691E-2
 1.257E-2 15 264

8: Pubmed [Display Chart] 46388 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20634891:gr Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. GeneRIF 8.841E-12 2.050E-7 2.322E-6 4.101E-7 16 331
2 20634891 Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Pubmed 8.841E-12 2.050E-7 2.322E-6 4.101E-7 16 331
3 16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Pubmed 5.456E-9 8.436E-5 9.551E-4 2.531E-4 12 257
4 15174051 An investigation into the human serum "interactome". Pubmed 1.048E-7 9.774E-4 1.107E-2 4.862E-3 9 162
5 24014171 Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology. Pubmed 1.066E-7 9.774E-4 1.107E-2 4.943E-3 4 10
6 18660489:gr Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. GeneRIF 4.354E-7 9.774E-4 1.107E-2 2.020E-2 10 250
7 18660489 Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. Pubmed 4.354E-7 9.774E-4 1.107E-2 2.020E-2 10 250
8 2780570 Changes in brain gene expression shared by scrapie and Alzheimer disease. Pubmed 4.361E-7 9.774E-4 1.107E-2 2.023E-2 3 4
9 16129691:gr Alpha7 integrin expression is negatively regulated by deltaEF1 during skeletal myogenesis. GeneRIF 4.361E-7 9.774E-4 1.107E-2 2.023E-2 3 4
10 15592854:gr Gene expression profiling of cathepsin D, metallothioneins-1 and -2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis. GeneRIF 4.361E-7 9.774E-4 1.107E-2 2.023E-2 3 4
11 18057022:gr Differential targeting of nNOS and AQP4 to dystrophin-deficient sarcolemma by membrane-directed alpha-dystrobrevin. GeneRIF 4.361E-7 9.774E-4 1.107E-2 2.023E-2 3 4
12 24189400 Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms. Pubmed 5.406E-7 9.774E-4 1.107E-2 2.508E-2 10 256
13 24722188 Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Pubmed 6.629E-7 9.774E-4 1.107E-2 3.075E-2 12 400
14 20889312 A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. Pubmed 7.522E-7 9.774E-4 1.107E-2 3.489E-2 6 65
15 17043677 Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Pubmed 7.766E-7 9.774E-4 1.107E-2 3.603E-2 8 151
16 20936779 A human MAP kinase interactome. Pubmed 8.194E-7 9.774E-4 1.107E-2 3.801E-2 13 486
17 20385826 Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Pubmed 9.028E-7 9.774E-4 1.107E-2 4.188E-2 4 16
18 9507007 High affinity binding and overlapping localization of neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta with tenascin-R, amphoterin, and the heparin-binding growth-associated molecule. Pubmed 1.086E-6 9.774E-4 1.107E-2
5.039E-2
 3 5
19 16712791 Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Pubmed 2.100E-6 9.774E-4 1.107E-2
9.740E-2
 12 447
20 20036812 Growth factors in tumor microenvironment. Pubmed 2.165E-6 9.774E-4 1.107E-2
1.004E-1
 3 6
21 16614106 GSTP1 genetic polymorphism is associated with a higher risk of DNA damage in pesticide-exposed fruit growers. Pubmed 2.165E-6 9.774E-4 1.107E-2
1.004E-1
 3 6
22 16614106:gr GSTP1 genetic polymorphism is associated with a higher risk of DNA damage in pesticide-exposed fruit growers. GeneRIF 2.165E-6 9.774E-4 1.107E-2
1.004E-1
 3 6
23 20036812:gr Growth factors in tumor microenvironment. GeneRIF 2.165E-6 9.774E-4 1.107E-2
1.004E-1
 3 6
24 25241761 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. Pubmed 2.178E-6 9.774E-4 1.107E-2
1.010E-1
 11 371
25 25056061 Biological insights from 108 schizophrenia-associated genetic loci. Pubmed 2.538E-6 9.774E-4 1.107E-2
1.177E-1
 10 304
26 23284715 Brain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteins. Pubmed 2.913E-6 9.774E-4 1.107E-2
1.351E-1
 4 21
27 19453261:gr High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. GeneRIF 2.954E-6 9.774E-4 1.107E-2
1.370E-1
 11 383
28 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 2.954E-6 9.774E-4 1.107E-2
1.370E-1
 11 383
29 20029029 Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Pubmed 2.979E-6 9.774E-4 1.107E-2
1.382E-1
 6 82
30 18207572:gr Polymorphisms in transporter and phase II metabolism genes as potential modifiers of the predisposition to and treatment outcome of de novo acute myeloid leukemia in Israeli ethnic groups. GeneRIF 3.775E-6 9.774E-4 1.107E-2
1.751E-1
 3 7
31 19686046 Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer's disease. Pubmed 3.775E-6 9.774E-4 1.107E-2
1.751E-1
 3 7
32 18207572 Polymorphisms in transporter and phase II metabolism genes as potential modifiers of the predisposition to and treatment outcome of de novo acute myeloid leukemia in Israeli ethnic groups. Pubmed 3.775E-6 9.774E-4 1.107E-2
1.751E-1
 3 7
33 19686046:gr Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer's disease. GeneRIF 3.775E-6 9.774E-4 1.107E-2
1.751E-1
 3 7
34 18413200:gr Oxidative stress pathway genes and chronic renal insufficiency in Asian Indians with Type 2 diabetes. GeneRIF 6.019E-6 9.774E-4 1.107E-2
2.792E-1
 3 8
35 18593984 Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms. Pubmed 6.019E-6 9.774E-4 1.107E-2
2.792E-1
 3 8
36 19931615 MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation. Pubmed 6.019E-6 9.774E-4 1.107E-2
2.792E-1
 3 8
37 18593984:gr Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms. GeneRIF 6.019E-6 9.774E-4 1.107E-2
2.792E-1
 3 8
38 18413200 Oxidative stress pathway genes and chronic renal insufficiency in Asian Indians with Type 2 diabetes. Pubmed 6.019E-6 9.774E-4 1.107E-2
2.792E-1
 3 8
39 19692168 Genetic susceptibility to distinct bladder cancer subphenotypes. Pubmed 7.388E-6 9.774E-4 1.107E-2
3.427E-1
 11 422
40 19692168:gr Genetic susceptibility to distinct bladder cancer subphenotypes. GeneRIF 7.388E-6 9.774E-4 1.107E-2
3.427E-1
 11 422
41 20534741 Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Pubmed 9.706E-6 9.774E-4 1.107E-2
4.503E-1
 4 28
42 22889411 Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. Pubmed 1.080E-5 9.774E-4 1.107E-2
5.009E-1
 5 60
43 20534741:gr Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. GeneRIF 1.122E-5 9.774E-4 1.107E-2
5.203E-1
 4 29
44 21423176 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for Ã?-Pix in negative regulation of focal adhesion maturation. Pubmed 1.152E-5 9.774E-4 1.107E-2
5.346E-1
 9 286
45 23455636 Seven new loci associated with age-related macular degeneration. Pubmed 1.289E-5 9.774E-4 1.107E-2
5.981E-1
 4 30
46 16502470 Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Pubmed 1.352E-5 9.774E-4 1.107E-2
6.271E-1
 7 160
47 19625176 PTEN identified as important risk factor of chronic obstructive pulmonary disease. Pubmed 1.621E-5 9.774E-4 1.107E-2
7.519E-1
 10 376
48 19625176:gr PTEN identified as important risk factor of chronic obstructive pulmonary disease. GeneRIF 1.621E-5 9.774E-4 1.107E-2
7.519E-1
 10 376
49 14718574 The human plasma proteome: a nonredundant list developed by combination of four separate sources. Pubmed 1.715E-5 9.774E-4 1.107E-2
7.958E-1
 7 166
50 19515364 Genetic background of lead and mercury metabolism in a group of medical students in Austria. Pubmed 1.755E-5 9.774E-4 1.107E-2
8.139E-1
 3 11
Show 45 more annotations

9: Interaction [Display Chart] 4193 annotations before applied cutoff / 16534 genes in category

No results to display

10: Cytoband [Display Chart] 207 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 5q21 5q21 7.233E-5 1.497E-2
8.853E-2
 1.497E-2 3 12

11: Transcription Factor Binding Site [Display Chart] 541 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$E47 02 V$E47 02 9.824E-6 5.315E-3 3.652E-2 5.315E-3 14 199
2 V$MEF2 02 V$MEF2 02 1.726E-4 3.231E-2
2.220E-1
9.336E-2
 12 197
3 V$MEF2 03 V$MEF2 03 1.809E-4 3.231E-2
2.220E-1
9.789E-2
 12 198
4 V$RSRFC4 01 V$RSRFC4 01 2.858E-4 3.231E-2
2.220E-1
1.546E-1
 12 208
5 V$PR Q2 V$PR Q2 2.986E-4 3.231E-2
2.220E-1
1.616E-1
 12 209
6 V$NF1 Q6 V$NF1 Q6 5.373E-4 4.844E-2
3.329E-1
2.907E-1
 12 223
Show 1 more annotation

12: Gene Family [Display Chart] 159 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 555 Fibronectin type III domain containing|Immunoglobulin like domain containing genenames.org 7.437E-7 1.182E-4 6.680E-4 1.182E-4 11 160
2 1278 SPARC family genenames.org 5.579E-5 4.402E-3 2.487E-2 8.871E-3 3 8
3 829 Copines genenames.org 8.306E-5 4.402E-3 2.487E-2 1.321E-2 3 9
4 870 Minor histocompatibility antigens genenames.org 1.656E-4 6.581E-3 3.718E-2 2.633E-2 5 51
5 892 Tissue inhibitor of metallopeptidases genenames.org 6.088E-4 1.613E-2
9.114E-2
9.680E-2
 2 4
6 1200 X-linked mental retardation|Glutamate ionotropic receptor AMPA type subunits genenames.org 6.088E-4 1.613E-2
9.114E-2
9.680E-2
 2 4
7 1208 ATPase Na+/K+ transporting subunits genenames.org 2.088E-3 4.743E-2
2.680E-1
3.320E-1
 2 7
Show 2 more annotations

13: Coexpression [Display Chart] 6928 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2121 Genes correlated with classical type of glioblastoma multiforme tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.244E-19 5.019E-15 4.728E-14 5.019E-15 23 162
2 M5547 Age up-regulated genes in the human frontal cortex. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.325E-16 1.152E-12 1.085E-11 2.304E-12 25 262
3 M1713 Genes enriched in astrocytes in the adult mouse brain identified through correlation-based searches seeded with the astrocyte cell-type specific gene expression patterns. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.704E-14 6.245E-11 5.883E-10 1.874E-10 12 42
4 M2892 Genes up-regulated in epithelial kidney cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v5.1) 5.890E-13 1.020E-9 9.611E-9 4.081E-9 17 143
5 M7396 Genes down-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.926E-13 1.098E-9 1.035E-8 5.491E-9 27 435
6 M2013 Genes with low-CpG-density promoters (LCP) bearing histone H3 trimethylation mark at K4 (H3K4me3) in neural progenitor cells (NPC). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.352E-12 1.561E-9 1.470E-8 9.365E-9 27 445
7 M12225 Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.284E-12 2.260E-9 2.129E-8 1.582E-8 19 205
8 M1796 The glioblastoma multiforme (GBM) plasticity signature: genes up-regulated in neural stem cells (NSC) with double knockout of TP53 and PTEN [GeneID=7157;5728] vs those with knockout of TP53 alone. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.053E-12 7.840E-9 7.386E-8 6.272E-8 20 250
9 M15472 Down-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.144E-10 1.650E-7 1.555E-6 1.485E-6 22 366
10 M1240 Genes down-regulated in early vs late brain tumors induced by retroviral delivery of PDGFB [GeneID=5155]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.609E-9 1.086E-6 1.023E-5 1.115E-5 9 45
11 M1350 Genes up-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 48 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.735E-9 1.086E-6 1.023E-5 1.202E-5 24 487
12 M2573 Genes consistently up-regulated in mammary stem cells both in mouse and human species. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.881E-9 1.086E-6 1.023E-5 1.303E-5 24 489
13 M14791 Genes down-regulated in colorectal adenoma compared to normal mucosa samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.386E-9 3.235E-6 3.047E-5 4.424E-5 18 291
14 M19391 Genes down-regulated in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.537E-9 3.235E-6 3.047E-5 4.529E-5 23 480
15 M1914 Genes up-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.108E-9 3.283E-6 3.093E-5 4.924E-5 18 293
16 M10276 Genes down-regulated in the neural crest stem cells (NCS), defined as p75+/HNK1+ [GeneID=4804;27087]. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.787E-9 4.238E-6 3.992E-5 6.780E-5 12 118
17 M14127 Genes up-regulated in multiple myeloma (MM) cell lines treated with both decitabine [PubChem=451668] TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.523E-8 6.207E-6 5.847E-5 1.055E-4 22 461
18 M10728 Genes down-regulated in hairy cell leukemia (HCL) compared with normal and other neoplastic B cell populations. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.321E-8 8.933E-6 8.416E-5 1.608E-4 10 80
19 M2395 Genes up-regulated in pancreatic islets upon knockout of HNF1A [GeneID=6927]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.470E-8 1.586E-5 1.494E-4 3.097E-4 13 163
20 M19097 Genes up-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.662E-8 1.586E-5 1.494E-4 3.230E-4 22 491
21 M12135 Genes down-regulated in apoptotic tissues (neuroepithelium) after MDM4 [GeneID=4194] knockout. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.807E-8 1.586E-5 1.494E-4 3.330E-4 13 164
22 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.970E-8 2.103E-5 1.981E-4 4.829E-4 21 460
23 M5446 Genes up-regulated in comparison of mast cells versus central memory CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v5.1) 6.980E-8 2.103E-5 1.981E-4 4.836E-4 14 200
24 M11581 Genes up-regulated in pilocytic astrocytoma compared to glioblastoma samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.107E-7 3.112E-5 2.932E-4 7.666E-4 7 35
25 M17471 Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS, non-invasive). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.123E-7 3.112E-5 2.932E-4 7.780E-4 18 351
26 M2293 Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.236E-7 3.294E-5 3.103E-4 8.565E-4 17 315
27 M1784 Genes changed in U373-MG cells (malignant glioma) upon treatment with arsenic trioxide [PubChem=14888], a chemical that can cause autophagic cell death. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.548E-7 3.972E-5 3.742E-4 1.073E-3 11 123
28 M13206 Genes down-regulated in TC71 and EWS502 cells (Ewing's sarcoma) by EWSR1-FLI1 [GeneID=2130;2314] as inferred from RNAi knockdown of this fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.015E-7 4.986E-5 4.697E-4 1.396E-3 17 326
29 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.968E-7 7.090E-5 6.679E-4 2.056E-3 15 260
30 M2634 Genes up-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] and engineered to express ligand-activatable EGFR [Gene ID=1956]. MSigDB C6: Oncogenic Signatures (v5.1) 3.222E-7 7.441E-5 7.010E-4 2.232E-3 13 193
31 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.122E-7 9.212E-5 8.678E-4 2.856E-3 19 425
32 GSE42724 NAIVE VS MEMORY BCELL DN Genes down-regulated in B lymphocytes: naïve versus memory. MSigDB C7: Immunologic Signatures (v5.1) 4.846E-7 9.948E-5 9.372E-4 3.358E-3 13 200
33 M5228 Genes down-regulated in comparison of dendritic cells (DC) exposed to 50 worms/well B. malayi versus DC exposed to M. tuberculosis MSigDB C7: Immunologic Signatures (v5.1) 4.846E-7 9.948E-5 9.372E-4 3.358E-3 13 200
34 M2571 Genes down-regulated during prostate cancer progression in the JOCK1 model due to inducible activation of FGFR1 [GeneID=2260] gene in prostate. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.882E-7 9.948E-5 9.372E-4 3.382E-3 16 308
35 M2237 Genes down-regulated in MDA-MB-231 cells (breast cancer) upon overexpression of PARVB [GeneID=29780] under all three culture conditions. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.363E-7 1.061E-4 1.000E-3 3.715E-3 8 63
36 M215 Selected genes up-regulated in prostate tumors developed by transgenic mice overexpressing VAV3 [GeneID=10451] in prostate epithelium. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.495E-7 1.442E-4 1.359E-3 5.192E-3 9 89
37 M1736 Cluster P7 of genes with similar expression profiles in peripheral T lymphocytes after FOXP3 [GeneID=50943] loss of function (LOF). MSigDB C2: CGP Curated Gene Sets (v5.1) 8.246E-7 1.544E-4 1.455E-3 5.713E-3 9 90
38 M10117 Genes down-regulated in acute myeloid leukemia (AML) patients with mutated NPM1 [GeneID=4869]. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.742E-7 1.594E-4 1.502E-3 6.057E-3 14 246
39 M19541 Genes commonly down-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.014E-6 1.802E-4 1.697E-3 7.027E-3 18 408
40 M7778 Genes down-regulated in Rh4 cells (alveolar rhabdomyosarcoma, ARMS) after knockdown of the PAX3-FOXO1 [GeneiD=5077;2308] fusion protein by RNAi for 72 hr. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.069E-6 1.807E-4 1.702E-3 7.408E-3 7 48
41 M260 Genes prefentially expressed in human inner ear tissue (cochlea and vestibule), at least 10-fold higher from a mixture of 29 other tissues. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.069E-6 1.807E-4 1.702E-3 7.408E-3 7 48
42 M1571 Genes down-regulated in embryonic stem cells from TCEB3 [GeneID=6924] knockout mice. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.099E-6 1.814E-4 1.708E-3 7.617E-3 13 215
43 M4680 Genes up-regulated in RD cells (embryonal rhabdomyosarcoma, ERMS) by expression of PAX3- or PAX7-FOXO1 [GeneID=5077;5081;2308] fusions off retroviral vectors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.340E-6 2.158E-4 2.033E-3 9.281E-3 14 255
44 M15835 Genes down-regulated SUM44/LCCTam cells (breast cancer) resistant to 4-hydroxytamoxifen [PubChem=63062] relative to the parental SUM44 cells sensitive to the drug. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.423E-6 2.240E-4 2.110E-3 9.855E-3 13 220
45 M11814 Genes down-regulated in Jurkat cells (T lymphocyte) by expression of a constitutively active form of IRF3 [GeneID=3661]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.804E-6 2.778E-4 2.617E-3 1.250E-2 5 19
46 M1351 Genes down-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 48 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.000E-6 2.989E-4 2.816E-3 1.386E-2 18 428
47 M2697 Genes down-regulated in NCI-60 panel of cell lines with mutated TP53 [Gene ID=7157]. MSigDB C6: Oncogenic Signatures (v5.1) 2.028E-6 2.989E-4 2.816E-3 1.405E-2 12 192
48 M8513 Genes up-regulated in the normal-like subtype of breast cancer. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.227E-6 3.214E-4 3.028E-3 1.543E-2 19 476
49 M4665 Genes down-regulated in glomeruli of kidneys from patients with diabetic nephropathy (type 2 diabetes mellitus). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.432E-6 3.390E-4 3.194E-3 1.685E-2 18 434
50 M12004 Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of both HDAC1 and HDAC2 [GeneID=3065;3066] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.447E-6 3.390E-4 3.194E-3 1.695E-2 13 231
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 3594 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 astrocytes Top 500 All astrocytes Top 500 All Brain Map - Barres 1.011E-94 3.635E-91 3.186E-90 3.635E-91 98 496
2 astrocytes Top 500 Cluster 4 astrocytes Top 500 Cluster 4 Brain Map - Barres 3.818E-44 6.862E-41 6.014E-40 1.372E-40 42 166
3 80Dn SubClass 80Dn 5 Top 500 All 80Dn SubClass 80Dn 5 Top 500 All Brain Map - Allen iN 3.414E-43 3.068E-40 2.689E-39 1.227E-39 59 474
4 80Dn SubClass 80Dn 5 Top 500 Cluster 0 80Dn SubClass 80Dn 5 Top 500 Cluster 0 Brain Map - Allen iN 3.414E-43 3.068E-40 2.689E-39 1.227E-39 59 474
5 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 1.298E-37 9.329E-35 8.177E-34 4.665E-34 55 493
6 54SK Top 500 All 54SK Top 500 All Brain Map - Allen iN 3.473E-29 2.081E-26 1.823E-25 1.248E-25 47 488
7 astrocytes Top 500 Cluster 0 astrocytes Top 500 Cluster 0 Brain Map - Barres 4.986E-26 2.560E-23 2.244E-22 1.792E-22 21 59
8 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 5.893E-24 2.648E-21 2.320E-20 2.118E-20 42 494
9 OPC Top 500 All OPC Top 500 All Brain Map - Barres 5.371E-23 2.145E-20 1.880E-19 1.930E-19 41 494
10 54SK SubClass 54SK 3 Top 500 All 54SK SubClass 54SK 3 Top 500 All Brain Map - Allen iN 1.918E-22 6.893E-20 6.041E-19 6.893E-19 40 482
11 endothelial SubClass DCN-hi Top 500 Cluster 4 endothelial SubClass DCN-hi Top 500 Cluster 4 Brain Map - Barres 9.980E-21 3.261E-18 2.858E-17 3.587E-17 12 16
12 26Dn SubClass 26Dn 2 Top 500 All 26Dn SubClass 26Dn 2 Top 500 All Brain Map - Allen iN 4.452E-20 1.333E-17 1.169E-16 1.600E-16 38 498
13 OPC Top 500 Cluster 4 OPC Top 500 Cluster 4 Brain Map - Barres 2.122E-19 5.868E-17 5.143E-16 7.628E-16 16 49
14 26Dn Top 500 All 26Dn Top 500 All Brain Map - Allen iN 3.095E-19 7.946E-17 6.964E-16 1.112E-15 37 496
15 gudmap developingGonad P2 testes 1000 k4 DevelopingGonad P2 testes emap-30171 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.429E-16 3.424E-14 3.001E-13 5.136E-13 28 319
16 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 2.792E-16 6.271E-14 5.496E-13 1.003E-12 32 445
17 54SK Top 500 Cluster 0 54SK Top 500 Cluster 0 Brain Map - Allen iN 5.197E-16 1.099E-13 9.629E-13 1.868E-12 22 185
18 54Dn Top 500 Cluster 4 54Dn Top 500 Cluster 4 Brain Map - Allen iN 6.236E-16 1.245E-13 1.091E-12 2.241E-12 19 126
19 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 3.742E-15 7.078E-13 6.203E-12 1.345E-11 31 455
20 gudmap dev gonad e12.5 M InterstitLeydig MafB 500 dev gonad e12.5 M InterstitLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.258E-14 5.855E-12 5.132E-11 1.171E-10 27 364
21 gudmap kidney adult JuxtaGlom Ren1 Captopr 500 kidney adult JuxtaGlom Ren1 Captopr top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.935E-14 1.187E-11 1.040E-10 2.493E-10 28 407
22 80Dn Top 500 Cluster 0 80Dn Top 500 Cluster 0 Brain Map - Allen iN 8.633E-14 1.410E-11 1.236E-10 3.103E-10 12 44
23 gudmap dev gonad e13.5 M InterstitFLeydig MafB 500 dev gonad e13.5 M InterstitFLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.436E-13 2.245E-11 1.967E-10 5.163E-10 26 356
24 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 1.504E-13 2.253E-11 1.975E-10 5.407E-10 29 453
25 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 3.238E-13 4.655E-11 4.079E-10 1.164E-9 29 467
26 GSM777063 500 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 8.125E-13 1.123E-10 9.844E-10 2.920E-9 28 450
27 gudmap developingGonad e18.5 testes 1000 k4 DevelopingGonad e18.5 testes emap-11164 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 8.810E-13 1.173E-10 1.028E-9 3.166E-9 23 293
28 gudmap kidney P0 JuxtaGlom Ren1 500 kidney P0 JuxtaGlom Ren1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.119E-12 1.437E-10 1.259E-9 4.023E-9 28 456
29 GSM777037 500 Stromal Cells, BEC.SLN, gp38- CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.311E-12 1.625E-10 1.424E-9 4.713E-9 28 459
30 54Dn SubClass 54Dn 2 Top 500 All 54Dn SubClass 54Dn 2 Top 500 All Brain Map - Allen iN 1.382E-12 1.655E-10 1.451E-9 4.966E-9 29 495
31 gudmap dev gonad e13.5 M InterstitTestis Sma 500 dev gonad e13.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.505E-12 1.745E-10 1.529E-9 5.408E-9 25 362
32 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 2.659E-12 2.964E-10 2.597E-9 9.555E-9 27 438
33 astrocytes Top 500 Cluster 2 astrocytes Top 500 Cluster 2 Brain Map - Barres 2.751E-12 2.964E-10 2.597E-9 9.886E-9 11 44
34 GSM777059 500 Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 2.804E-12 2.964E-10 2.597E-9 1.008E-8 27 439
35 54SK SubClass 54SK 3 Top 500 Cluster 4 54SK SubClass 54SK 3 Top 500 Cluster 4 Brain Map - Allen iN 3.603E-12 3.700E-10 3.243E-9 1.295E-8 11 45
36 oligodendrocytes Top 500 Cluster 2 oligodendrocytes Top 500 Cluster 2 Brain Map - Barres 3.918E-12 3.912E-10 3.428E-9 1.408E-8 12 59
37 54SK SubClass 54SK 3 Top 500 Cluster 2 54SK SubClass 54SK 3 Top 500 Cluster 2 Brain Map - Allen iN 6.216E-12 6.038E-10 5.292E-9 2.234E-8 17 158
38 GSM777032 500 Stromal Cells, BEC.MLN, gp38- CD31+, Lymph Node, avg-5 Immgen.org, GSE15907 6.764E-12 6.398E-10 5.607E-9 2.431E-8 27 456
39 oligodendrocytes Top 500 All oligodendrocytes Top 500 All Brain Map - Barres 9.191E-12 8.470E-10 7.424E-9 3.303E-8 28 498
40 gudmap kidney adult Mesangium Meis 500 kidney adult Mesangium Meis top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.012E-11 9.095E-10 7.971E-9 3.638E-8 26 429
41 gudmap dev gonad e12.5 M InterstitLeydig MafB k4 1000 dev gonad e12.5 M InterstitLeydig MafB k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.398E-11 1.226E-9 1.074E-8 5.025E-8 18 191
42 Lungmap Mouse e16.5 Matrix fibroblast SubClass Mature fibroblast 1 Top 500 All Mouse Lung E16.5 Mature fibroblast 1 top500 Lungmap Mouse Single Cell (Lungmap.net) 2.022E-11 1.730E-9 1.516E-8 7.267E-8 24 374
43 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k3 1000 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.883E-11 3.245E-9 2.844E-8 1.395E-7 18 203
44 gudmap dev gonad e12.5 M InterstitTestis Sma k1 1000 dev gonad e12.5 M InterstitTestis Sma k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 4.969E-11 3.976E-9 3.484E-8 1.786E-7 16 155
45 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 4.978E-11 3.976E-9 3.484E-8 1.789E-7 26 461
46 gudmap dev gonad e13.5 M SertoliCell Sox9 500 dev gonad e13.5 M SertoliCell Sox9 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 7.294E-11 5.577E-9 4.888E-8 2.621E-7 25 433
47 GSM605856 500 Myeloid Cells, MF.Thio5.II+480int.PC, CD115+ MHC II+ F480lo SiglecF- CD11c+, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 7.294E-11 5.577E-9 4.888E-8 2.621E-7 25 433
48 gudmap kidney adult JuxtaGlom Ren1 500 kidney adult JuxtaGlom Ren1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 8.563E-11 6.412E-9 5.619E-8 3.078E-7 24 401
49 gudmap dev gonad e13.5 M SertoliCell Sox9 k4 1000 dev gonad e13.5 M SertoliCell Sox9 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 9.143E-11 6.706E-9 5.878E-8 3.286E-7 26 474
50 gudmap dev gonad e12.5 M SertoliCell Sox9 500 dev gonad e12.5 M SertoliCell Sox9 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.075E-10 7.724E-9 6.770E-8 3.862E-7 25 441
Show 45 more annotations

15: Computational [Display Chart] 444 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 1.754E-16 7.787E-14 5.197E-13 7.787E-14 35 351
2 GCM MAPK10 Neighborhood of MAPK10 MSigDb: C4 - CGN: Cancer Gene Neighborhood 7.050E-12 1.565E-9 1.045E-8 3.130E-9 15 76
3 GCM AQP4 Neighborhood of AQP4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.873E-9 8.692E-7 5.801E-6 2.608E-6 10 44
4 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 5.464E-7 6.065E-5 4.048E-4 2.426E-4 23 378
5 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 1.230E-5 1.092E-3 7.289E-3 5.460E-3 15 216
6 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 4.734E-5 3.503E-3 2.338E-2 2.102E-2 20 395
7 module 112 Genes in module 112 MSigDb: C4 - CM: Cancer Modules 9.273E-5 5.733E-3 3.826E-2 4.117E-2 15 257
8 GCM SIRT2 Neighborhood of SIRT2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.033E-4 5.733E-3 3.826E-2 4.586E-2 6 41
9 module 176 Genes in module 176 MSigDb: C4 - CM: Cancer Modules 3.305E-4 1.630E-2
1.088E-1
1.467E-1
 13 227
10 GCM MAP4K4 Neighborhood of MAP4K4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.270E-4 1.893E-2
1.263E-1
1.896E-1
 10 147
11 module 128 Genes in module 128 MSigDb: C4 - CM: Cancer Modules 4.837E-4 1.893E-2
1.263E-1
2.147E-1
 8 98
12 module 170 Genes in module 170 MSigDb: C4 - CM: Cancer Modules 5.541E-4 1.893E-2
1.263E-1
2.460E-1
 8 100
13 module 79 Genes in module 79 MSigDb: C4 - CM: Cancer Modules 5.541E-4 1.893E-2
1.263E-1
2.460E-1
 8 100
14 module 324 Genes in module 324 MSigDb: C4 - CM: Cancer Modules 7.701E-4 2.442E-2
1.630E-1
3.419E-1
 9 131
15 module 223 Genes in module 223 MSigDb: C4 - CM: Cancer Modules 1.236E-3 3.448E-2
2.301E-1
5.488E-1
 9 140
16 module 220 Genes in module 220 MSigDb: C4 - CM: Cancer Modules 1.243E-3 3.448E-2
2.301E-1
5.517E-1
 15 328
17 module 19 Genes in module 19 MSigDb: C4 - CM: Cancer Modules 1.851E-3 4.834E-2
3.226E-1
8.218E-1
 14 307
Show 12 more annotations

16: MicroRNA [Display Chart] 1369 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-448:PITA hsa-miR-448:PITA TOP PITA 6.545E-7 8.960E-4 6.988E-3 8.960E-4 20 438
2 miR-153:PicTar miR-153:PicTar PicTar 5.463E-6 3.740E-3 2.917E-2 7.479E-3 17 377
3 hsa-miR-452:PITA hsa-miR-452:PITA TOP PITA 1.529E-5 6.978E-3
5.442E-2
 2.093E-2 18 451
4 miR-9-star:PicTar miR-9-star:PicTar PicTar 3.066E-5 9.275E-3
7.234E-2
 4.198E-2 14 305
5 hsa-miR-101:PITA hsa-miR-101:PITA TOP PITA 3.388E-5 9.275E-3
7.234E-2
 4.638E-2 18 479
6 hsa-miR-935:PITA hsa-miR-935:PITA TOP PITA 5.638E-5 1.286E-2
1.003E-1
7.719E-2
 13 282
7 hsa-miR-331-5p:PITA hsa-miR-331-5p:PITA TOP PITA 7.358E-5 1.341E-2
1.046E-1
1.007E-1
 9 142
8 hsa-miR-27a:miRTarbase hsa-miR-27a:miRTarbase miRTarbase 7.838E-5 1.341E-2
1.046E-1
1.073E-1
 4 19
9 hsa-miR-590-5p:PITA hsa-miR-590-5p:PITA TOP PITA 1.115E-4 1.449E-2
1.130E-1
1.526E-1
 12 261
10 miR-144:PicTar miR-144:PicTar PicTar 1.128E-4 1.449E-2
1.130E-1
1.544E-1
 16 433
11 hsa-miR-21:PITA hsa-miR-21:PITA TOP PITA 1.198E-4 1.449E-2
1.130E-1
1.639E-1
 12 263
12 hsa-miR-575:PITA hsa-miR-575:PITA TOP PITA 1.281E-4 1.449E-2
1.130E-1
1.753E-1
 10 188
13 TTTGTAG,MIR-520D:MSigDB TTTGTAG,MIR-520D:MSigDB MSigDB 1.458E-4 1.449E-2
1.130E-1
1.996E-1
 13 310
14 hsa-miR-206:miRTarbase hsa-miR-206:miRTarbase miRTarbase 1.514E-4 1.449E-2
1.130E-1
2.073E-1
 3 9
15 hsa-miR-516b:PITA hsa-miR-516b:PITA TOP PITA 1.588E-4 1.449E-2
1.130E-1
2.173E-1
 10 193
16 miR-135a:PicTar miR-135a:PicTar PicTar 1.842E-4 1.576E-2
1.229E-1
2.522E-1
 14 361
17 miR-135b:PicTar miR-135b:PicTar PicTar 2.063E-4 1.661E-2
1.296E-1
2.824E-1
 14 365
18 CTATGCA,MIR-153:MSigDB CTATGCA,MIR-153:MSigDB MSigDB 2.297E-4 1.747E-2
1.362E-1
3.144E-1
 10 202
19 hsa-miR-888:PITA hsa-miR-888:PITA TOP PITA 2.658E-4 1.878E-2
1.464E-1
3.639E-1
 15 420
20 miR-199a-star:PicTar miR-199a-star:PicTar PicTar 2.796E-4 1.878E-2
1.464E-1
3.827E-1
 15 422
21 hsa-miR-590-5p:TargetScan hsa-miR-590-5p:TargetScan TargetScan 3.017E-4 1.878E-2
1.464E-1
4.131E-1
 10 209
22 hsa-miR-21:TargetScan hsa-miR-21:TargetScan TargetScan 3.017E-4 1.878E-2
1.464E-1
4.131E-1
 10 209
23 hsa-miR-375:TargetScan hsa-miR-375:TargetScan TargetScan 3.744E-4 2.197E-2
1.713E-1
5.126E-1
 8 140
24 hsa-miR-539:PITA hsa-miR-539:PITA TOP PITA 3.851E-4 2.197E-2
1.713E-1
5.272E-1
 16 483
25 miR-32:PicTar miR-32:PicTar PicTar 4.766E-4 2.610E-2
2.036E-1
6.525E-1
 15 444
26 miR-142-5p:PicTar miR-142-5p:PicTar PicTar 5.070E-4 2.642E-2
2.061E-1
6.940E-1
 12 308
27 miR-139:PicTar miR-139:PicTar PicTar 5.211E-4 2.642E-2
2.061E-1
7.133E-1
 10 224
28 hsa-miR-598:mirSVR lowEffct hsa-miR-598:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 5.863E-4 2.866E-2
2.236E-1
8.026E-1
 15 453
29 miR-92:PicTar miR-92:PicTar PicTar 7.085E-4 3.345E-2
2.609E-1
9.700E-1
 14 413
30 TCTGATA,MIR-361:MSigDB TCTGATA,MIR-361:MSigDB MSigDB 7.621E-4 3.450E-2
2.691E-1
1.000E0
 6 87
31 hsa-miR-205:PITA hsa-miR-205:PITA TOP PITA 8.058E-4 3.450E-2
2.691E-1
1.000E0
 11 280
32 hsa-miR-1273:mirSVR highEffct hsa-miR-1273:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.065E-4 3.450E-2
2.691E-1
1.000E0
 9 196
33 hsa-miR-103:TargetScan hsa-miR-103:TargetScan TargetScan 8.900E-4 3.584E-2
2.795E-1
1.000E0
 15 472
34 hsa-miR-107:TargetScan hsa-miR-107:TargetScan TargetScan 8.900E-4 3.584E-2
2.795E-1
1.000E0
 15 472
35 CAGTGTT,MIR-200A:MSigDB CAGTGTT,MIR-200A:MSigDB MSigDB 1.101E-3 4.117E-2
3.211E-1
1.000E0
 11 291
36 CAGTGTT,MIR-141:MSigDB CAGTGTT,MIR-141:MSigDB MSigDB 1.101E-3 4.117E-2
3.211E-1
1.000E0
 11 291
37 hsa-miR-659:PITA hsa-miR-659:PITA TOP PITA 1.171E-3 4.117E-2
3.211E-1
1.000E0
 10 249
38 hsa-miR-509-5p:PITA hsa-miR-509-5p:PITA TOP PITA 1.196E-3 4.117E-2
3.211E-1
1.000E0
 11 294
39 hsa-miR-509-3-5p:PITA hsa-miR-509-3-5p:PITA TOP PITA 1.196E-3 4.117E-2
3.211E-1
1.000E0
 11 294
40 hsa-miR-153:PITA hsa-miR-153:PITA TOP PITA 1.290E-3 4.117E-2
3.211E-1
1.000E0
 12 343
41 miR-129:PicTar miR-129:PicTar PicTar 1.353E-3 4.117E-2
3.211E-1
1.000E0
 9 211
42 hsa-miR-191:mirSVR highEffct hsa-miR-191:mirSVR conserved highEffect-0.5 MicroRNA.org 1.493E-3 4.117E-2
3.211E-1
1.000E0
 12 349
43 hsa-miR-206:miRecords TarBase hsa-miR-206:miRecords TarBase miRecords_TarBase 1.505E-3 4.117E-2
3.211E-1
1.000E0
 2 5
44 hsa-miR-7:miRecords TarBase hsa-miR-7:miRecords TarBase miRecords_TarBase 1.505E-3 4.117E-2
3.211E-1
1.000E0
 2 5
45 TTGGAGA,MIR-515-5P:MSigDB TTGGAGA,MIR-515-5P:MSigDB MSigDB 1.526E-3 4.117E-2
3.211E-1
1.000E0
 7 135
46 TTGGAGA,MIR-519E:MSigDB TTGGAGA,MIR-519E:MSigDB MSigDB 1.526E-3 4.117E-2
3.211E-1
1.000E0
 7 135
47 hsa-miR-1200:PITA hsa-miR-1200:PITA TOP PITA 1.529E-3 4.117E-2
3.211E-1
1.000E0
 12 350
48 hsa-miR-155:PITA hsa-miR-155:PITA TOP PITA 1.561E-3 4.117E-2
3.211E-1
1.000E0
 11 304
49 hsa-miR-1294:PITA hsa-miR-1294:PITA TOP PITA 1.606E-3 4.117E-2
3.211E-1
1.000E0
 8 175
50 hsa-miR-873:TargetScan hsa-miR-873:TargetScan TargetScan 1.664E-3 4.117E-2
3.211E-1
1.000E0
 8 176
Show 45 more annotations

17: Drug [Display Chart] 25861 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3688 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 2.273E-10 4.769E-6 5.121E-5 5.879E-6 16 181
2 1220 UP SAHA; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 3.688E-10 4.769E-6 5.121E-5 9.538E-6 15 160
3 C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone CTD 3.960E-9 3.329E-5 3.574E-4 1.024E-4 19 320
4 7331 UP Naftopidil dihydrochloride [57149-08-3]; Up 200; 8.6uM; MCF7; HT HG-U133A Broad Institute CMAP 7.072E-9 3.329E-5 3.574E-4 1.829E-4 15 198
5 4837 UP Catechin-(+,-) hydrate [7295-85-4]; Up 200; 13.8uM; MCF7; HT HG-U133A Broad Institute CMAP 8.106E-9 3.329E-5 3.574E-4 2.096E-4 15 200
6 6405 UP PF-01378883-00 [351320-41-7]; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 8.106E-9 3.329E-5 3.574E-4 2.096E-4 15 200
7 C013698 tallow CTD 9.010E-9 3.329E-5 3.574E-4 2.330E-4 17 266
8 5764 UP Terbutaline hemisulfate [23031-32-5]; Up 200; 7.2uM; PC3; HT HG-U133A Broad Institute CMAP 2.005E-8 6.480E-5 6.958E-4 5.184E-4 14 183
9 5882 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 2.822E-8 8.108E-5 8.706E-4 7.297E-4 14 188
10 C038328 BEP protocol CTD 3.961E-8 1.024E-4 1.100E-3 1.024E-3 13 163
11 4444 UP SAHA; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 4.578E-8 1.048E-4 1.126E-3 1.184E-3 13 165
12 D010656 Phenylephrine CTD 5.348E-8 1.048E-4 1.126E-3 1.383E-3 22 500
13 D000641 Ammonia CTD 5.581E-8 1.048E-4 1.126E-3 1.443E-3 8 48
14 D008743 Methyl Parathion CTD 5.725E-8 1.048E-4 1.126E-3 1.480E-3 9 67
15 4632 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 6.080E-8 1.048E-4 1.126E-3 1.572E-3 13 169
16 4458 UP Trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 6.986E-8 1.129E-4 1.213E-3 1.807E-3 13 171
17 3993 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.048E-7 1.594E-4 1.712E-3 2.710E-3 13 177
18 1786 UP Chelidonine monohydrate (+) [476-32-4]; Up 200; 10.8uM; HL60; HG-U133A Broad Institute CMAP 1.843E-7 2.647E-4 2.843E-3 4.765E-3 12 155
19 5119 UP Prednicarbate [73771-04-7]; Up 200; 8.2uM; PC3; HT HG-U133A Broad Institute CMAP 3.225E-7 3.860E-4 4.145E-3 8.340E-3 13 195
20 4484 UP Pipenzolate bromide [125-51-9]; Up 200; 9.2uM; PC3; HT HG-U133A Broad Institute CMAP 3.420E-7 3.860E-4 4.145E-3 8.845E-3 13 196
21 7137 UP Methylprednisolone, 6-alpha [83-43-2]; Up 200; 10.6uM; PC3; HT HG-U133A Broad Institute CMAP 3.420E-7 3.860E-4 4.145E-3 8.845E-3 13 196
22 7301 DN Gliquidone [33342-05-1]; Down 200; 7.6uM; PC3; HT HG-U133A Broad Institute CMAP 3.626E-7 3.860E-4 4.145E-3 9.377E-3 13 197
23 3875 UP Quinethazone [73-49-4]; Up 200; 13.8uM; MCF7; HT HG-U133A Broad Institute CMAP 3.626E-7 3.860E-4 4.145E-3 9.377E-3 13 197
24 5823 UP Ipratropium bromide [22254-24-6]; Up 200; 9.8uM; PC3; HT HG-U133A Broad Institute CMAP 3.626E-7 3.860E-4 4.145E-3 9.377E-3 13 197
25 5062 UP Imidurea [39236-46-9]; Up 200; 10.4uM; PC3; HT HG-U133A Broad Institute CMAP 3.843E-7 3.860E-4 4.145E-3 9.937E-3 13 198
26 MESH:D011471/C017947-M Prostatic Neoplasms affected by sodium arsenite CTD Marker 3.881E-7 3.860E-4 4.145E-3 1.004E-2 11 136
27 2403 UP Pergolide mesylate [66104-23-2]; Up 200; 9.8uM; HL60; HT HG-U133A Broad Institute CMAP 4.138E-7 3.963E-4 4.256E-3 1.070E-2 12 167
28 3131 UP Scopoletin [92-61-5]; Up 200; 20.8uM; HL60; HT HG-U133A Broad Institute CMAP 4.311E-7 3.982E-4 4.276E-3 1.115E-2 13 200
29 2105 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 6.044E-7 5.390E-4 5.787E-3 1.563E-2 12 173
30 C002202 4-oxoretinoic acid CTD 6.771E-7 5.523E-4 5.930E-3 1.751E-2 10 115
31 CID000003816 NSC759587 Stitch 6.819E-7 5.523E-4 5.930E-3 1.764E-2 19 444
32 1746 UP Mometasone furoate [83919-23-7]; Up 200; 7.6uM; HL60; HG-U133A Broad Institute CMAP 6.834E-7 5.523E-4 5.930E-3 1.767E-2 12 175
33 5441 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 7.262E-7 5.524E-4 5.931E-3 1.878E-2 12 176
34 6896 UP scriptaid; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 7.262E-7 5.524E-4 5.931E-3 1.878E-2 12 176
35 4590 UP Etilefrine hydrochloride [534-87-2]; Up 200; 18.4uM; PC3; HT HG-U133A Broad Institute CMAP 7.714E-7 5.542E-4 5.950E-3 1.995E-2 12 177
36 5745 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 7.714E-7 5.542E-4 5.950E-3 1.995E-2 12 177
37 5940 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 8.191E-7 5.574E-4 5.986E-3 2.118E-2 12 178
38 2685 UP 17-AAG; Up 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP 8.191E-7 5.574E-4 5.986E-3 2.118E-2 12 178
39 4184 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 8.694E-7 5.765E-4 6.190E-3 2.248E-2 12 179
40 3787 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 9.223E-7 5.963E-4 6.403E-3 2.385E-2 12 180
41 5802 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 9.782E-7 6.023E-4 6.467E-3 2.530E-2 12 181
42 4457 UP rosiglitazone; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 9.782E-7 6.023E-4 6.467E-3 2.530E-2 12 181
43 6316 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.037E-6 6.120E-4 6.571E-3 2.682E-2 12 182
44 CID000024766 chondroitin sulfate Stitch 1.041E-6 6.120E-4 6.571E-3 2.693E-2 18 413
45 2576 UP Alexidine dihydrochloride [22573-93-9]; Up 200; 6.8uM; HL60; HT HG-U133A Broad Institute CMAP 1.099E-6 6.178E-4 6.634E-3 2.842E-2 12 183
46 7084 UP MS-275; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 1.099E-6 6.178E-4 6.634E-3 2.842E-2 12 183
47 C056507 gemcitabine CTD 1.132E-6 6.228E-4 6.688E-3 2.927E-2 14 254
48 7074 UP MS-275; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 1.164E-6 6.272E-4 6.734E-3 3.010E-2 12 184
49 C487081 belinostat CTD 1.195E-6 6.305E-4 6.770E-3 3.090E-2 18 417
50 4380 UP CP-690334-01 [459212-38-5]; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.305E-6 6.616E-4 7.104E-3 3.374E-2 12 186
Show 45 more annotations

18: Disease [Display Chart] 3174 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0334579 Anaplastic astrocytoma DisGeNET Curated 4.274E-9 1.357E-5 1.172E-4 1.357E-5 14 137
2 umls:C0025286 Meningioma DisGeNET Curated 4.811E-8 7.635E-5 6.597E-4 1.527E-4 21 383
3 umls:C0017601 Glaucoma DisGeNET Curated 1.301E-7 1.376E-4 1.189E-3 4.129E-4 14 179
4 umls:C0162309 Adrenoleukodystrophy DisGeNET Curated 2.238E-7 1.776E-4 1.534E-3 7.102E-4 12 133
5 umls:C0238198 Gastrointestinal Stromal Tumors DisGeNET Curated 2.141E-6 1.079E-3 9.323E-3 6.794E-3 16 293
6 umls:C0334583 Pilocytic Astrocytoma DisGeNET Curated 2.653E-6 1.079E-3 9.323E-3 8.422E-3 9 88
7 umls:C0025500 Mesothelioma DisGeNET Curated 2.661E-6 1.079E-3 9.323E-3 8.446E-3 17 334
8 umls:C0151744 Myocardial Ischemia DisGeNET Curated 3.012E-6 1.079E-3 9.323E-3 9.559E-3 19 413
9 umls:C0007115 Malignant neoplasm of thyroid DisGeNET BeFree 3.059E-6 1.079E-3 9.323E-3 9.711E-3 20 453
10 umls:C1621958 Glioblastoma Multiforme DisGeNET BeFree 6.162E-6 1.956E-3 1.690E-2 1.956E-2 19 434
11 umls:C1762616 Meningioma, benign, no ICD-O subtype DisGeNET BeFree 7.318E-6 2.111E-3 1.824E-2 2.323E-2 13 217
12 umls:C0027626 Neoplasm Invasiveness DisGeNET Curated 1.122E-5 2.967E-3 2.564E-2 3.560E-2 10 132
13 umls:C0086543 Cataract DisGeNET Curated 1.329E-5 3.244E-3 2.803E-2 4.217E-2 12 196
14 umls:C0014556 Epilepsy, Temporal Lobe DisGeNET Curated 3.041E-5 6.894E-3
5.957E-2
9.652E-2
 10 148
15 umls:C0026850 Muscular Dystrophy DisGeNET Curated 3.487E-5 7.378E-3
6.375E-2
1.107E-1
 12 216
16 umls:C0027439 Nasopharyngeal Neoplasms DisGeNET Curated 3.784E-5 7.506E-3
6.486E-2
1.201E-1
 4 15
17 umls:C0345967 Malignant mesothelioma DisGeNET Curated 5.996E-5 1.119E-2
9.672E-2
1.903E-1
 13 265
18 umls:C0242383 Age related macular degeneration DisGeNET Curated 6.941E-5 1.224E-2
1.057E-1
2.203E-1
 15 347
19 umls:C0281361 Adenocarcinoma of pancreas DisGeNET BeFree 7.375E-5 1.232E-2
1.065E-1
2.341E-1
 14 309
20 umls:C0027765 nervous system disorder DisGeNET Curated 8.204E-5 1.240E-2
1.071E-1
2.604E-1
 17 436
21 umls:C1269683 Major Depressive Disorder DisGeNET Curated 8.204E-5 1.240E-2
1.071E-1
2.604E-1
 17 436
22 umls:C0022665 Kidney Neoplasm DisGeNET Curated 8.857E-5 1.278E-2
1.104E-1
2.811E-1
 11 202
23 umls:C0948441 Venoocclusive disease DisGeNET BeFree 1.030E-4 1.388E-2
1.199E-1
3.270E-1
 4 19
24 umls:C0023448 Lymphoid leukemia DisGeNET Curated 1.101E-4 1.388E-2
1.199E-1
3.495E-1
 11 207
25 umls:C0041696 Unipolar Depression DisGeNET BeFree 1.145E-4 1.388E-2
1.199E-1
3.633E-1
 16 405
26 umls:C0028945 oligodendroglioma DisGeNET Curated 1.191E-4 1.388E-2
1.199E-1
3.779E-1
 10 174
27 umls:C1561643 Chronic Kidney Diseases DisGeNET Curated 1.205E-4 1.388E-2
1.199E-1
3.826E-1
 13 284
28 umls:C1868193 PNEUMOTHORAX, PRIMARY SPONTANEOUS DisGeNET Curated 1.257E-4 1.388E-2
1.199E-1
3.991E-1
 3 8
29 umls:C0494165 Secondary malignant neoplasm of liver DisGeNET BeFree 1.268E-4 1.388E-2
1.199E-1
4.026E-1
 17 452
30 umls:C0555198 Malignant Glioma DisGeNET BeFree 1.394E-4 1.475E-2
1.274E-1
4.425E-1
 16 412
31 umls:C0003469 Anxiety Disorders DisGeNET Curated 1.457E-4 1.492E-2
1.289E-1
4.625E-1
 15 371
32 umls:C0035309 Retinal Diseases DisGeNET Curated 1.587E-4 1.570E-2
1.356E-1
5.038E-1
 13 292
33 umls:C0011884 Diabetic Retinopathy DisGeNET Curated 1.646E-4 1.570E-2
1.356E-1
5.225E-1
 10 181
34 umls:C0920506 Environment-Related Malignant Neoplasm DisGeNET BeFree 1.781E-4 1.570E-2
1.356E-1
5.652E-1
 2 2
35 umls:C1291317 Deficiency of transferase DisGeNET BeFree 1.781E-4 1.570E-2
1.356E-1
5.652E-1
 2 2
36 umls:C2931860 Monosomy 5p DisGeNET Curated 1.781E-4 1.570E-2
1.356E-1
5.652E-1
 2 2
37 umls:C0034885 Rectal Neoplasms DisGeNET Curated 1.836E-4 1.575E-2
1.361E-1
5.829E-1
 5 40
38 umls:C0677898 invasive cancer DisGeNET BeFree 1.887E-4 1.576E-2
1.362E-1
5.989E-1
 9 150
39 umls:C0035304 Retinal Degeneration DisGeNET Curated 2.035E-4 1.642E-2
1.419E-1
6.458E-1
 11 222
40 umls:C0279628 Adenocarcinoma Of Esophagus DisGeNET Curated 2.070E-4 1.642E-2
1.419E-1
6.569E-1
 13 300
41 umls:C0740457 Malignant neoplasm of kidney DisGeNET BeFree 2.178E-4 1.686E-2
1.457E-1
6.912E-1
 15 385
42 umls:C0279980 Extraosseous Ewings sarcoma-primitive neuroepithelial tumor DisGeNET BeFree 2.285E-4 1.727E-2
1.492E-1
7.254E-1
 6 65
43 umls:C0206663 Neuroectodermal Tumor, Primitive DisGeNET Curated 2.482E-4 1.793E-2
1.550E-1
7.878E-1
 8 123
44 umls:C0595936 Aqueous Humor Disorders DisGeNET BeFree 2.486E-4 1.793E-2
1.550E-1
7.891E-1
 6 66
45 umls:C0042345 Varicosity DisGeNET Curated 2.601E-4 1.823E-2
1.575E-1
8.254E-1
 5 43
46 umls:C0014850 Esophageal Atresia DisGeNET BeFree 2.642E-4 1.823E-2
1.575E-1
8.385E-1
 3 10
47 umls:C0011570 Mental Depression DisGeNET Curated 2.709E-4 1.829E-2
1.581E-1
8.598E-1
 17 482
48 umls:C0040136 Thyroid Neoplasm DisGeNET Curated 3.026E-4 2.001E-2
1.729E-1
9.605E-1
 13 312
49 umls:C0206728 Plexiform Neurofibroma DisGeNET Curated 3.157E-4 2.045E-2
1.767E-1
1.000E0
 4 25
50 umls:C0038356 Stomach Neoplasms DisGeNET Curated 3.277E-4 2.076E-2
1.793E-1
1.000E0
 17 490
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