Toppgene analysis for aggregated_1964_log, IC27, negative side

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1: GO: Molecular Function [Display Chart] 180 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001047 core promoter binding 4.071E-4 4.462E-2
2.576E-1
7.329E-2
 4 165
2 GO:0008320 protein transmembrane transporter activity 7.362E-4 4.462E-2
2.576E-1
1.325E-1
 2 19
3 GO:0022884 macromolecule transmembrane transporter activity 9.906E-4 4.462E-2
2.576E-1
1.783E-1
 2 22
4 GO:0001046 core promoter sequence-specific DNA binding 1.863E-3 4.462E-2
2.576E-1
3.353E-1
 3 115
5 GO:0070626 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity 2.126E-3 4.462E-2
2.576E-1
3.826E-1
 1 1
6 GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity 2.126E-3 4.462E-2
2.576E-1
3.826E-1
 1 1
7 GO:0019809 spermidine binding 2.126E-3 4.462E-2
2.576E-1
3.826E-1
 1 1
8 GO:0019780 FAT10 activating enzyme activity 2.126E-3 4.462E-2
2.576E-1
3.826E-1
 1 1
9 GO:0050699 WW domain binding 2.231E-3 4.462E-2
2.576E-1
4.016E-1
 2 33
10 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2.651E-3 4.772E-2
2.755E-1
4.772E-1
 2 36
Show 5 more annotations

2: GO: Biological Process [Display Chart] 1363 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0034198 cellular response to amino acid starvation 2.525E-5 3.442E-2
2.683E-1
 3.442E-2 3 27

3: GO: Cellular Component [Display Chart] 113 annotations before applied cutoff / 19172 genes in category

No results to display

4: Human Phenotype [Display Chart] 232 annotations before applied cutoff / 4410 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 922 annotations before applied cutoff / 9299 genes in category

No results to display

6: Domain [Display Chart] 276 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR021156 TF A-like/BEX InterPro 3.782E-4 1.597E-2
9.898E-2
1.044E-1
 2 14
2 PF04538 BEX Pfam 3.782E-4 1.597E-2
9.898E-2
1.044E-1
 2 14
3 IPR013057 AA transpt TM InterPro 5.630E-4 1.597E-2
9.898E-2
1.554E-1
 2 17
4 PF01490 Aa trans Pfam 5.630E-4 1.597E-2
9.898E-2
1.554E-1
 2 17
5 PS00292 CYCLINS PROSITE 1.542E-3 1.597E-2
9.898E-2
4.257E-1
 2 28
6 IPR029668 TMEM98 InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
7 PF10397 ADSL C Pfam 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
8 IPR033757 WTAP InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
9 IPR019156 Ataxin-10 domain InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
10 PF08212 Lipocalin 2 Pfam 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
11 PF15811 SVIP Pfam 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
12 IPR001901 Translocase SecE/Sec61-g InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
13 IPR023391 Prot translocase SecE dom InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
14 PS01067 SECE SEC61G PROSITE 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
15 SM00998 ADSL C SMART 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
16 IPR026222 ApoD vertbrte InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
17 IPR022943 SecE InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
18 IPR008158 Translocase Sec61-g InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
19 PF09759 Atx10homo assoc Pfam 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
20 IPR012715 Chap CCT alpha InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
21 IPR026778 MLLT11 fam InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
22 PF17098 Wtap Pfam 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
23 IPR019468 AdenyloSucc lyase C InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
24 1.20.5.820 - Gene3D 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
25 IPR005683 Tom22 InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
26 IPR002969 ApolipopD InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
27 PD619568 PD619568 ProDom 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
28 IPR031632 SVIP InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
29 IPR029732 WTAP/Mum2 InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
30 IPR029551 SOX-11 InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
31 PF00584 SecE Pfam 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
32 IPR029811 ATF4 InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
33 PF04281 Tom22 Pfam 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
34 IPR004769 Pur lyase InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
35 IPR032957 SAT1 InterPro 2.082E-3 1.597E-2
9.898E-2
5.745E-1
 1 1
36 PF00134 Cyclin N Pfam 2.140E-3 1.597E-2
9.898E-2
5.907E-1
 2 33
37 IPR006671 Cyclin N InterPro 2.140E-3 1.597E-2
9.898E-2
5.907E-1
 2 33
38 SM00385 CYCLIN SMART 2.831E-3 2.056E-2
1.275E-1
7.814E-1
 2 38
39 1.10.472.10 - Gene3D 3.133E-3 2.217E-2
1.375E-1
8.647E-1
 2 40
40 IPR013763 Cyclin-like InterPro 3.613E-3 2.493E-2
1.545E-1
9.971E-1
 2 43
41 IPR031658 Cyclin C 2 InterPro 4.159E-3 2.493E-2
1.545E-1
1.000E0
 1 2
42 PF16899 Cyclin C 2 Pfam 4.159E-3 2.493E-2
1.545E-1
1.000E0
 1 2
43 IPR022271 Lipocalin ApoD InterPro 4.159E-3 2.493E-2
1.545E-1
1.000E0
 1 2
44 IPR002449 Retinol-bd/Purpurin InterPro 4.159E-3 2.493E-2
1.545E-1
1.000E0
 1 2
45 IPR018075 UBQ-activ enz E1 InterPro 6.232E-3 2.493E-2
1.545E-1
1.000E0
 1 3
46 SM01193 Enolase N SMART 6.232E-3 2.493E-2
1.545E-1
1.000E0
 1 3
47 IPR020811 Enolase N InterPro 6.232E-3 2.493E-2
1.545E-1
1.000E0
 1 3
48 IPR018965 Ub-activating enz E1 C InterPro 6.232E-3 2.493E-2
1.545E-1
1.000E0
 1 3
49 IPR020809 Enolase CS InterPro 6.232E-3 2.493E-2
1.545E-1
1.000E0
 1 3
50 IPR032418 E1 FCCH InterPro 6.232E-3 2.493E-2
1.545E-1
1.000E0
 1 3
Show 45 more annotations

7: Pathway [Display Chart] 457 annotations before applied cutoff / 10916 genes in category

No results to display

8: Pubmed [Display Chart] 6133 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 23408887 Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transport. Pubmed 5.802E-7 3.954E-4 3.677E-3 3.558E-3 2 2
2 19801969 Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms. Pubmed 5.802E-7 3.954E-4 3.677E-3 3.558E-3 2 2
3 17934069:gr Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma. GeneRIF 5.802E-7 3.954E-4 3.677E-3 3.558E-3 2 2
4 18697751:gr Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed in HepG2 cells. GeneRIF 5.802E-7 3.954E-4 3.677E-3 3.558E-3 2 2
5 22642745 SOX11 is useful in differentiating cyclin D1-positive diffuse large B-cell lymphoma from mantle cell lymphoma. Pubmed 5.802E-7 3.954E-4 3.677E-3 3.558E-3 2 2
6 17934069 Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma. Pubmed 5.802E-7 3.954E-4 3.677E-3 3.558E-3 2 2
7 8812443 Assignment of the human cytosolic acetoacetyl-coenzyme A thiolase (ACAT2) gene to chromosome 6q25.3-q26. Pubmed 5.802E-7 3.954E-4 3.677E-3 3.558E-3 2 2
8 23648671 SOX11 overexpression is a specific marker for mantle cell lymphoma and correlates with t(11;14) translocation, CCND1 expression and an adverse prognosis. Pubmed 5.802E-7 3.954E-4 3.677E-3 3.558E-3 2 2
9 19801969:gr Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms. GeneRIF 5.802E-7 3.954E-4 3.677E-3 3.558E-3 2 2
10 21182205 Identification of proteins associated with ligand-activated estrogen receptor ¿ in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. Pubmed 1.300E-6 7.970E-4 7.411E-3 7.970E-3 5 245
11 27129276 Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells. Pubmed 1.740E-6 8.208E-4 7.632E-3 1.067E-2 2 3
12 11593423 Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein. Pubmed 1.740E-6 8.208E-4 7.632E-3 1.067E-2 2 3
13 1833066 Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Pubmed 1.740E-6 8.208E-4 7.632E-3 1.067E-2 2 3
14 15461802 A genome annotation-driven approach to cloning the human ORFeome. Pubmed 3.167E-6 1.333E-3 1.240E-2 1.943E-2 5 294
15 18697751 Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed in HepG2 cells. Pubmed 3.478E-6 1.333E-3 1.240E-2 2.133E-2 2 4
16 7568034 Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. Pubmed 3.478E-6 1.333E-3 1.240E-2 2.133E-2 2 4
17 12539042 HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. Pubmed 5.509E-6 1.870E-3 1.739E-2 3.379E-2 3 44
18 18703994 Amino acid transport systems beta and A in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. Pubmed 5.794E-6 1.870E-3 1.739E-2 3.553E-2 2 5
19 18703994:gr Amino acid transport systems beta and A in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. GeneRIF 5.794E-6 1.870E-3 1.739E-2 3.553E-2 2 5
20 22113938 A bead-based approach for large-scale identification of in vitro kinase substrates. Pubmed 7.873E-6 2.202E-3 2.047E-2 4.829E-2 4 163
21 15713663 Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. Pubmed 1.215E-5 2.202E-3 2.047E-2
7.454E-2
 2 7
22 19995069 Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. Pubmed 1.215E-5 2.202E-3 2.047E-2
7.454E-2
 2 7
23 21319273 An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. Pubmed 1.354E-5 2.202E-3 2.047E-2
8.304E-2
 5 397
24 25640309 Systematic identification of molecular links between core and candidate genes in breast cancer. Pubmed 1.562E-5 2.202E-3 2.047E-2
9.581E-2
 4 194
25 16082198 p21WAF1/CIP1 regulates the p300 sumoylation motif CRD1 through a C-terminal domain independently of cyclin/CDK binding. Pubmed 1.620E-5 2.202E-3 2.047E-2
9.934E-2
 2 8
26 20663877 Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase. Pubmed 1.620E-5 2.202E-3 2.047E-2
9.934E-2
 2 8
27 9150135 Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Pubmed 2.082E-5 2.202E-3 2.047E-2
1.277E-1
 2 9
28 25621764 Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. Pubmed 4.501E-5 2.202E-3 2.047E-2
2.761E-1
 2 13
29 23506890 Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Pubmed 6.054E-5 2.202E-3 2.047E-2
3.713E-1
 2 15
30 10591208 The DNA sequence of human chromosome 22. Pubmed 8.517E-5 2.202E-3 2.047E-2
5.223E-1
 4 300
31 16221301 Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. Pubmed 1.584E-4 2.202E-3 2.047E-2
9.716E-1
 2 24
32 19282863:gr Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension. GeneRIF 1.721E-4 2.202E-3 2.047E-2
1.000E0
 2 25
33 22505724 Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Pubmed 1.732E-4 2.202E-3 2.047E-2
1.000E0
 3 139
34 23181366 Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells. Pubmed 1.864E-4 2.202E-3 2.047E-2
1.000E0
 2 26
35 19282863 Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension. Pubmed 1.864E-4 2.202E-3 2.047E-2
1.000E0
 2 26
36 19578796:gr Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. GeneRIF 2.253E-4 2.202E-3 2.047E-2
1.000E0
 3 152
37 19578796 Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. Pubmed 2.253E-4 2.202E-3 2.047E-2
1.000E0
 3 152
38 22751105 Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. Pubmed 2.572E-4 2.202E-3 2.047E-2
1.000E0
 3 159
39 20398657 The steroid receptor RNA activator protein is recruited to promoter regions and acts as a transcriptional repressor. Pubmed 2.660E-4 2.202E-3 2.047E-2
1.000E0
 2 31
40 18195088 Amino acid transport across mammalian intestinal and renal epithelia. Pubmed 2.660E-4 2.202E-3 2.047E-2
1.000E0
 2 31
41 24816145 A COFRADIC protocol to study protein ubiquitination. Pubmed 3.183E-4 2.202E-3 2.047E-2
1.000E0
 3 171
42 21963094 Global identification of modular cullin-RING ligase substrates. Pubmed 3.579E-4 2.202E-3 2.047E-2
1.000E0
 3 178
43 21907836 Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). Pubmed 4.396E-4 2.202E-3 2.047E-2
1.000E0
 3 191
44 23825951 Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing. Pubmed 4.442E-4 2.202E-3 2.047E-2
1.000E0
 2 40
45 26362536 Proteomic analysis of HIV-1 Gag interacting partners using proximity-dependent biotinylation. Pubmed 4.899E-4 2.202E-3 2.047E-2
1.000E0
 2 42
46 18247557 A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins. Pubmed 5.135E-4 2.202E-3 2.047E-2
1.000E0
 2 43
47 24244333 Profiling of Parkin-binding partners using tandem affinity purification. Pubmed 5.249E-4 2.202E-3 2.047E-2
1.000E0
 3 203
48 21906983 Systematic and quantitative assessment of the ubiquitin-modified proteome. Pubmed 5.555E-4 2.202E-3 2.047E-2
1.000E0
 3 207
49 25496916 A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1. Pubmed 5.625E-4 2.202E-3 2.047E-2
1.000E0
 2 45
50 21890473 A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Pubmed 5.713E-4 2.202E-3 2.047E-2
1.000E0
 3 209
Show 45 more annotations

9: Interaction [Display Chart] 1735 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:GOLGA1 GOLGA1 interactions 5.000E-6 8.675E-3
6.971E-2
 8.675E-3 3 15
2 int:CSNK2A1 CSNK2A1 interactions 1.017E-5 8.825E-3
7.092E-2
 1.765E-2 8 476

10: Cytoband [Display Chart] 36 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6q25-q27 6q25-q27 2.249E-3 2.870E-2
1.198E-1
8.097E-2
 1 2
2 6q25.3-q26 6q25.3-q26 2.249E-3 2.870E-2
1.198E-1
8.097E-2
 1 2
3 7q22.2 7q22.2 3.372E-3 2.870E-2
1.198E-1
1.214E-1
 1 3
4 22q12-q13 22q12-q13 4.493E-3 2.870E-2
1.198E-1
1.618E-1
 1 4
5 22q13.1 22q13.1 4.542E-3 2.870E-2
1.198E-1
1.635E-1
 2 89
6 6q21 6q21 6.032E-3 2.870E-2
1.198E-1
2.172E-1
 2 103
7 2q23.1 2q23.1 7.850E-3 2.870E-2
1.198E-1
2.826E-1
 1 7
8 Xp22.1 Xp22.1 7.850E-3 2.870E-2
1.198E-1
2.826E-1
 1 7
9 11p14.2 11p14.2 7.850E-3 2.870E-2
1.198E-1
2.826E-1
 1 7
10 11q13 11q13 7.972E-3 2.870E-2
1.198E-1
2.870E-1
 2 119
Show 5 more annotations

11: Transcription Factor Binding Site [Display Chart] 290 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$E2F Q3 V$E2F Q3 1.077E-4 2.128E-2
1.330E-1
 3.124E-2 5 177
2 V$E2F1 Q4 V$E2F1 Q4 1.467E-4 2.128E-2
1.330E-1
 4.255E-2 5 189
3 SMTTTTGT UNKNOWN SMTTTTGT UNKNOWN 2.580E-4 2.494E-2
1.558E-1
7.481E-2
 6 337
4 V$HTF 01 V$HTF 01 4.487E-4 3.253E-2
2.033E-1
1.301E-1
 3 55
5 V$E2F1 Q4 01 V$E2F1 Q4 01 1.433E-3 4.873E-2
3.045E-1
4.155E-1
 4 181
6 V$E2F Q6 V$E2F Q6 1.462E-3 4.873E-2
3.045E-1
4.240E-1
 4 182
7 V$E2F Q4 V$E2F Q4 1.522E-3 4.873E-2
3.045E-1
4.415E-1
 4 184
8 V$E2F Q4 01 V$E2F Q4 01 1.553E-3 4.873E-2
3.045E-1
4.504E-1
 4 185
9 V$E2F Q3 01 V$E2F Q3 01 1.584E-3 4.873E-2
3.045E-1
4.594E-1
 4 186
10 V$HP1SITEFACTOR Q6 V$HP1SITEFACTOR Q6 1.680E-3 4.873E-2
3.045E-1
4.873E-1
 4 189
Show 5 more annotations

12: Gene Family [Display Chart] 32 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 473 Cyclins|Mediator complex genenames.org 8.400E-4 2.688E-2
1.091E-1
 2.688E-2 2 29
2 989 Histone deacetylases, class I|EMSY complex|NuRD complex|SIN3 histone deacetylase complex genenames.org 5.923E-3 4.039E-2
1.639E-1
1.895E-1
 1 4
3 1217 Brain expressed X-linked family genenames.org 7.399E-3 4.039E-2
1.639E-1
2.368E-1
 1 5
4 995 Pyrin domain containing|Pyrin and HIN domain family genenames.org 7.399E-3 4.039E-2
1.639E-1
2.368E-1
 1 5
5 411 Ataxins genenames.org 8.872E-3 4.039E-2
1.639E-1
2.839E-1
 1 6
6 1299 BCL2 family|BCH domain containing genenames.org 1.034E-2 4.039E-2
1.639E-1
3.310E-1
 1 7
7 1229 Translocase of outer mitochondrial membrane complex genenames.org 1.034E-2 4.039E-2
1.639E-1
3.310E-1
 1 7
8 1216 Transcription elongation factor A like family genenames.org 1.328E-2 4.039E-2
1.639E-1
4.250E-1
 1 9
9 1306 ASAP complex|SIN3 histone deacetylase complex genenames.org 1.328E-2 4.039E-2
1.639E-1
4.250E-1
 1 9
10 100 Ubiquitin like modifier activating enzymes genenames.org 1.474E-2 4.039E-2
1.639E-1
4.718E-1
 1 10
11 455 Bone morphogenetic proteins|Endogenous ligands genenames.org 1.621E-2 4.039E-2
1.639E-1
5.187E-1
 1 11
12 737 RNA binding motif containing|Serine and arginine rich splicing factors genenames.org 1.767E-2 4.039E-2
1.639E-1
5.654E-1
 1 12
13 1243 PHD finger proteins|AT-rich interaction domain containing|Lysine demethylases|EMSY complex genenames.org 1.767E-2 4.039E-2
1.639E-1
5.654E-1
 1 12
14 1305 PHD finger proteins|NuRD complex genenames.org 1.767E-2 4.039E-2
1.639E-1
5.654E-1
 1 12
15 752 Pseudoautosomal region 1|Solute carriers genenames.org 2.019E-2 4.308E-2
1.748E-1
6.462E-1
 3 395
16 587 Chaperonins genenames.org 2.204E-2 4.408E-2
1.789E-1
7.052E-1
 1 15
17 631 Lipocalins genenames.org 2.784E-2 4.949E-2
2.008E-1
8.908E-1
 1 19
18 757 SRY-boxes genenames.org 2.784E-2 4.949E-2
2.008E-1
8.908E-1
 1 19
Show 13 more annotations

13: Coexpression [Display Chart] 2961 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2148 Human orthologs of genes down-regulated in the crb ('crash and burn') zebrafish mutant that represents a loss-of-function mutation in BMYB [GeneID=4605]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.070E-5 4.464E-2
3.826E-1
6.130E-2
 5 184
2 M11840 Human orthologs of genes down-regulated in zebra fish after knockdown of BMYB [GeneID=4605] by morpholino. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.015E-5 4.464E-2
3.826E-1
8.927E-2
 5 199
3 M4665 Genes down-regulated in glomeruli of kidneys from patients with diabetic nephropathy (type 2 diabetes mellitus). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.280E-4 4.836E-2
4.145E-1
3.789E-1
 6 434
4 M2137 Genes identified as synthetic lethal with imatinib [PubChemID=5291] in RNAi screen in K562 cells (CML, chronic myelogenous leukemia). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.408E-4 4.836E-2
4.145E-1
4.169E-1
 4 145
5 M15491 Genes down-regulated in MDA-MB-231 cells (breast cancer) after knockdown of SATB1 [GeneID=6304] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.413E-4 4.836E-2
4.145E-1
4.185E-1
 6 442
6 M6890 Genes down-regulated in at least one of three multiple myeloma (MM) cell lines by TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.812E-4 4.836E-2
4.145E-1
5.365E-1
 5 291
7 M17693 Genes up-regulated in Daudi cells (B lymphocytes) stably expressing CD5 [GeneID=921] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.041E-4 4.836E-2
4.145E-1
6.043E-1
 6 473
8 M1459 Genes up-regulated in BEC (blood endothelial cells) compared to LEC (lymphatic endothelial cells). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.155E-4 4.836E-2
4.145E-1
6.380E-1
 4 162
9 M2371 Genes down-regulated by VHL [GeneID=7428] and re-expressed under hypoxia conditions in renal carcinoma cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.513E-4 4.836E-2
4.145E-1
7.440E-1
 2 13
10 M2293 Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.615E-4 4.836E-2
4.145E-1
7.743E-1
 5 315
11 M1542 Genes up-regulated in embryonic stem cells from TCEB3 [GeneID=6924] knockout mice. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.893E-4 4.836E-2
4.145E-1
8.565E-1
 4 175
12 M15973 Human orthologs of BMYB [GeneID=4605] target genes in zebra fish, identified as commonly changed in the BMYB loss of function mutant crb ('crush and burn') and after knockdown of BMYB by morpholino. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.227E-4 4.836E-2
4.145E-1
9.556E-1
 3 73
13 M3652 Genes up-regulated in HT1080 cells (fibrosarcoma) by treatment with interferon alpha for 6 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.359E-4 4.836E-2
4.145E-1
9.947E-1
 3 74
14 M9143 Genes up-regulated in senescent cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.776E-4 4.836E-2
4.145E-1
1.000E0
 3 77
15 M2208 Potential targets of MIR302A [GeneID=407028]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.776E-4 4.836E-2
4.145E-1
1.000E0
 3 77
16 M1126 Genes up-regulated in malignant skin tumors (squamous cell carcinoma, SCC) formed by treatment with DMBA and TPA [PubChem=6001;4792] in the two stage skin carcinogenesis model. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.852E-4 4.836E-2
4.145E-1
1.000E0
 2 16
17 M13796 Genes up-regulated in a mouse model of heart disease whose expression reverted to normal by silencing of MIR21 [GeneID=406991] microRNA. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.361E-4 4.836E-2
4.145E-1
1.000E0
 2 17
18 GSE18281 SUBCAPSULAR VS CENTRAL CORTICAL REGION OF THYMUS UP Genes up-regulated in thymus cortical regions: subcapsular versus central cortical. MSigDB C7: Immunologic Signatures (v5.1) 4.618E-4 4.836E-2
4.145E-1
1.000E0
 4 198
19 M5491 Genes up-regulated in comparison of macrophages versus neutrophils. MSigDB C7: Immunologic Signatures (v5.1) 4.706E-4 4.836E-2
4.145E-1
1.000E0
 4 199
20 M5235 Genes up-regulated in comparison of macrophages exposed to L. donovani versus macrophages exposed to 50 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v5.1) 4.706E-4 4.836E-2
4.145E-1
1.000E0
 4 199
21 M4412 Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus unstimulated memory CD4 [GeneID=920] CD8 T cells. MSigDB C7: Immunologic Signatures (v5.1) 4.796E-4 4.836E-2
4.145E-1
1.000E0
 4 200
22 M2719 Genes down-regulated in primary thyrocyte cultures in response to cAMP signaling pathway activation by thyrotropin (TSH). MSigDB C6: Oncogenic Signatures (v5.1) 4.796E-4 4.836E-2
4.145E-1
1.000E0
 4 200
23 M3474 Genes up-regulated in comparison of CD4 [GeneID=920] thymocytes versus naive CD4 [GeneID=920] T cells from adult blood. MSigDB C7: Immunologic Signatures (v5.1) 4.796E-4 4.836E-2
4.145E-1
1.000E0
 4 200
24 M4473 Genes up-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated neutrophils. MSigDB C7: Immunologic Signatures (v5.1) 4.796E-4 4.836E-2
4.145E-1
1.000E0
 4 200
25 M5209 Genes up-regulated in comparison of dendritic cells (DC) exposed to L. major versus DCs exposed to 50 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v5.1) 4.796E-4 4.836E-2
4.145E-1
1.000E0
 4 200
26 M5901 Genes involved in the G2/M checkpoint, as in progression through the cell division cycle. MSigDB H: Hallmark Gene Sets (v5.1) 4.796E-4 4.836E-2
4.145E-1
1.000E0
 4 200
27 M5153 Genes down-regulated in comparison of dendritic cells (DC) versus DCs exposed to B. malayi (5 worms/well). MSigDB C7: Immunologic Signatures (v5.1) 4.796E-4 4.836E-2
4.145E-1
1.000E0
 4 200
28 M5533 Genes down-regulated in comparison of neutrophils versus Th1 cells. MSigDB C7: Immunologic Signatures (v5.1) 4.796E-4 4.836E-2
4.145E-1
1.000E0
 4 200
29 M2583 Down-regulated genes associated with the acquision of metastatic potential in LNM35 cells (large cell lung cancer). MSigDB C2: CGP Curated Gene Sets (v5.1) 4.900E-4 4.836E-2
4.145E-1
1.000E0
 2 18
30 M17552 Genes down-regulated in RCC4 cells (renal cell carcinoma) engineered to stably express VHL [GeneID=7428] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.900E-4 4.836E-2
4.145E-1
1.000E0
 2 18
Show 25 more annotations

14: Coexpression Atlas [Display Chart] 1572 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 fetal quiescent Top 500 Cluster 3 fetal quiescent Top 500 Cluster 3 Brain Map - Barres 1.091E-6 1.389E-3 1.102E-2 1.715E-3 4 41
2 fetal quiescent Top 500 All fetal quiescent Top 500 All Brain Map - Barres 3.290E-6 1.389E-3 1.102E-2 5.172E-3 8 489
3 26Dp Top 500 All 26Dp Top 500 All Brain Map - Allen iN 3.600E-6 1.389E-3 1.102E-2 5.660E-3 8 495
4 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k1 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.863E-6 1.389E-3 1.102E-2 6.072E-3 5 125
5 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 k4 1000 dev lower uro neuro e14.5 PelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 4.861E-6 1.389E-3 1.102E-2 7.641E-3 5 131
6 gudmap kidney e10.5 UretericTip HoxB7 k2 500 kidney e10.5 UretericTip HoxB7 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.494E-6 1.389E-3 1.102E-2 1.021E-2 5 139
7 26Dp SubClass 26Dp 3 Top 500 Cluster 1 26Dp SubClass 26Dp 3 Top 500 Cluster 1 Brain Map - Allen iN 7.162E-6 1.389E-3 1.102E-2 1.126E-2 3 20
8 gudmap kidney e10.5 UretericTip HoxB7 500 kidney e10.5 UretericTip HoxB7 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.230E-6 1.389E-3 1.102E-2 1.137E-2 7 384
9 gudmap kidney P3 CapMes Crym k2 500 kidney P3 CapMes Crym k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 8.816E-6 1.389E-3 1.102E-2 1.386E-2 5 148
10 gudmap kidney e10.5 UretericTrunk HoxB7 500 kidney e10.5 UretericTrunk HoxB7 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 8.835E-6 1.389E-3 1.102E-2 1.389E-2 7 396
11 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k4 1000 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.378E-5 1.970E-3 1.563E-2 2.167E-2 6 279
12 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 200 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 1.725E-5 2.260E-3 1.794E-2 2.712E-2 5 170
13 gudmap kidney e10.5 UretericTrunk HoxB7 k4 500 kidney e10.5 UretericTrunk HoxB7 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.960E-5 2.370E-3 1.881E-2 3.081E-2 4 84
14 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 200 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 3.253E-5 3.623E-3 2.876E-2
5.113E-2
 5 194
15 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 100 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 3.457E-5 3.623E-3 2.876E-2
5.435E-2
 4 97
16 80Dp Top 500 Cluster 3 80Dp Top 500 Cluster 3 Brain Map - Allen iN 3.691E-5 3.626E-3 2.878E-2
5.802E-2
 3 34
17 gudmap kidney e10.5 UretericTip HoxB7 k4 1000 kidney e10.5 UretericTip HoxB7 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.765E-5 4.240E-3 3.366E-2
7.490E-2
 6 348
18 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k1 1000 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 4.855E-5 4.240E-3 3.366E-2
7.632E-2
 5 211
19 54Dp SubClass 54Dp 5 Top 500 Cluster 1 54Dp SubClass 54Dp 5 Top 500 Cluster 1 Brain Map - Allen iN 5.176E-5 4.282E-3 3.399E-2
8.136E-2
 3 38
20 12Dp Top 500 Cluster 0 12Dp Top 500 Cluster 0 Brain Map - Allen iN 6.045E-5 4.752E-3 3.772E-2
9.503E-2
 3 40
21 gudmap kidney e15.5 Podocyte MafB k3 1000 kidney e15.5 Podocyte MafB k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.082E-4 8.098E-3
6.428E-2
1.701E-1
 5 250
22 26Dp Top 500 Cluster 1 26Dp Top 500 Cluster 1 Brain Map - Allen iN 1.184E-4 8.457E-3
6.713E-2
1.861E-1
 3 50
23 neurons SubClass GLRA2-hi Top 500 Cluster 4 neurons SubClass GLRA2-hi Top 500 Cluster 4 Brain Map - Barres 1.256E-4 8.584E-3
6.813E-2
1.974E-1
 3 51
24 26Dn SubClass 26Dn 4 Top 500 Cluster 4 26Dn SubClass 26Dn 4 Top 500 Cluster 4 Brain Map - Allen iN 1.409E-4 9.229E-3
7.326E-2
2.215E-1
 3 53
25 gudmap kidney single cell e11.5 MetanephMesench Scamp 200 kidney single cell e11.5 MetanephMesench StemCellamp top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.523E-4 9.375E-3
7.442E-2
2.394E-1
 4 142
26 gudmap developingKidney e15.5 Ureteral Smooth Musc 1000 k2 DevelopingKidney e15.5 Ureteral Smooth Musc emap-28812 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.551E-4 9.375E-3
7.442E-2
2.437E-1
 5 270
27 26Dp SubClass 26Dp 3 Top 500 All 26Dp SubClass 26Dp 3 Top 500 All Brain Map - Allen iN 2.302E-4 1.298E-2
1.031E-1
3.618E-1
 6 464
28 endothelial Top 500 Cluster 3 endothelial Top 500 Cluster 3 Brain Map - Barres 2.312E-4 1.298E-2
1.031E-1
3.635E-1
 2 12
29 54Dp SubClass 54Dp 4 Top 500 All 54Dp SubClass 54Dp 4 Top 500 All Brain Map - Allen iN 2.640E-4 1.431E-2
1.136E-1
4.150E-1
 6 476
30 gudmap kidney P4 CapMesRenVes Crym k3 500 kidney P4 CapMesRenVes Crym k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.769E-4 1.451E-2
1.152E-1
4.353E-1
 4 166
31 12Dp Top 500 All 12Dp Top 500 All Brain Map - Allen iN 2.951E-4 1.497E-2
1.188E-1
4.640E-1
 6 486
32 80Dp Top 500 All 80Dp Top 500 All Brain Map - Allen iN 3.118E-4 1.510E-2
1.199E-1
4.901E-1
 6 491
33 gudmap kidney P3 CapMes Crym k4 1000 kidney P3 CapMes Crym k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.258E-4 1.510E-2
1.199E-1
5.122E-1
 5 317
34 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 3.291E-4 1.510E-2
1.199E-1
5.173E-1
 6 496
35 oligodendrocytes Top 500 All oligodendrocytes Top 500 All Brain Map - Barres 3.362E-4 1.510E-2
1.199E-1
5.286E-1
 6 498
36 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 100 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 3.945E-4 1.723E-2
1.367E-1
6.202E-1
 3 75
37 gudmap kidney single cell e11.5 MetanephMesench Scamp 500 kidney single cell e11.5 MetanephMesench StemCellamp top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.429E-4 1.857E-2
1.474E-1
6.962E-1
 5 339
38 Facebase RNAseq e10.5 Neural Epithelium Overlying Central Eminence 1000 K3 FacebaseRNAseq e10.5 Neural Epithelium Overlying Central Eminence top-relative-expression-ranked 1000 k-means-cluster#3 FaceBase_RNAseq 4.489E-4 1.857E-2
1.474E-1
7.056E-1
 5 340
39 gudmap kidney P2 CapMes Crym k1 1000 kidney P2 CapMes Crym k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.713E-4 1.900E-2
1.508E-1
7.409E-1
 4 191
40 Facebase RNAseq e10.5 Neural Epithelium Overlying Medial Eminence 2500 K5 FacebaseRNAseq e10.5 Neural Epithelium Overlying Medial Eminence top-relative-expression-ranked 2500 k-means-cluster#5 FaceBase_RNAseq 5.121E-4 1.992E-2
1.581E-1
8.051E-1
 5 350
41 Facebase RNAseq e10.5 Neural Epithelium Overlying Medial Eminence 1000 K2 FacebaseRNAseq e10.5 Neural Epithelium Overlying Medial Eminence top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 5.195E-4 1.992E-2
1.581E-1
8.166E-1
 4 196
42 Lungmap Mouse e16.5 Myofibro SubClass Smooth Muscle-like Myofibroblast Top 500 Cluster 2 Mouse Lung E16.5 Myofibroblast Smooth Muscle-like Myofibroblast c2 Lungmap Mouse Single Cell (Lungmap.net) 5.322E-4 1.992E-2
1.581E-1
8.366E-1
 2 18
43 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 k1 500 dev lower uro neuro e14.5 PelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 5.501E-4 2.011E-2
1.596E-1
8.648E-1
 3 84
44 54Dp SubClass 54Dp 4 Top 500 Cluster 1 54Dp SubClass 54Dp 4 Top 500 Cluster 1 Brain Map - Allen iN 5.893E-4 2.059E-2
1.634E-1
9.264E-1
 3 86
45 26Dp Top 500 Cluster 2 26Dp Top 500 Cluster 2 Brain Map - Allen iN 5.893E-4 2.059E-2
1.634E-1
9.264E-1
 3 86
46 gudmap kidney e13.5 Podocyte MafB k3 1000 kidney e13.5 Podocyte MafB k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.377E-4 2.121E-2
1.683E-1
1.000E0
 4 207
47 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 500 k2 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.514E-4 2.121E-2
1.683E-1
1.000E0
 3 89
48 gudmap kidney P3 CapMes Crym 500 kidney P3 CapMes Crym top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.586E-4 2.121E-2
1.683E-1
1.000E0
 5 370
49 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 1000 k1 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.610E-4 2.121E-2
1.683E-1
1.000E0
 4 209
50 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.749E-4 2.122E-2
1.684E-1
1.000E0
 5 372
Show 45 more annotations

15: Computational [Display Chart] 213 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MORF HDAC1 Neighborhood of HDAC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.163E-4 2.476E-2
1.471E-1
 2.476E-2 6 226
2 MORF GNB1 Neighborhood of GNB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.869E-4 3.724E-2
2.212E-1
8.240E-2
 6 282
3 MORF XRCC5 Neighborhood of XRCC5 MSigDb: C4 - CGN: Cancer Gene Neighborhood 8.240E-4 3.724E-2
2.212E-1
1.755E-1
 5 214
4 MORF SNRP70 Neighborhood of SNRP70 MSigDb: C4 - CGN: Cancer Gene Neighborhood 8.658E-4 3.724E-2
2.212E-1
1.844E-1
 3 54
5 MORF EIF3S2 Neighborhood of EIF3S2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.012E-3 3.724E-2
2.212E-1
2.156E-1
 5 224
6 module 15 Genes in module 15 MSigDb: C4 - CM: Cancer Modules 1.206E-3 3.724E-2
2.212E-1
2.569E-1
 6 350
7 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 1.224E-3 3.724E-2
2.212E-1
2.607E-1
 6 351
8 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 1.790E-3 4.527E-2
2.690E-1
3.813E-1
 6 378
9 MORF PPP1CC Neighborhood of PPP1CC MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.913E-3 4.527E-2
2.690E-1
4.075E-1
 4 153
10 GNF2 AF1Q Neighborhood of AF1Q MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.183E-3 4.650E-2
2.763E-1
4.650E-1
 2 20
11 MORF CCNI Neighborhood of CCNI MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.508E-3 4.856E-2
2.885E-1
5.342E-1
 3 78
12 MORF PRDX3 Neighborhood of PRDX3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.793E-3 4.957E-2
2.945E-1
5.948E-1
 3 81
Show 7 more annotations

16: MicroRNA [Display Chart] 829 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1264:PITA hsa-miR-1264:PITA TOP PITA 2.292E-6 1.900E-3 1.386E-2 1.900E-3 8 453
2 hsa-miR-219-2-3p:PITA hsa-miR-219-2-3p:PITA TOP PITA 3.374E-5 1.399E-2
1.021E-1
 2.797E-2 5 190
3 hsa-miR-550:PITA hsa-miR-550:PITA TOP PITA 5.683E-5 1.570E-2
1.146E-1
 4.711E-2 4 107
4 miR-323:PicTar miR-323:PicTar PicTar 1.192E-4 1.962E-2
1.432E-1
9.878E-2
 5 248
5 miR-23a:PicTar miR-23a:PicTar PicTar 1.607E-4 1.962E-2
1.432E-1
1.332E-1
 6 422
6 miR-23b:PicTar miR-23b:PicTar PicTar 1.649E-4 1.962E-2
1.432E-1
1.367E-1
 6 424
7 GGCACAT,MIR-455:MSigDB GGCACAT,MIR-455:MSigDB MSigDB 1.716E-4 1.962E-2
1.432E-1
1.422E-1
 3 55
8 hsa-miR-924:PITA hsa-miR-924:PITA TOP PITA 1.893E-4 1.962E-2
1.432E-1
1.569E-1
 4 146
9 hsa-miR-500:PITA hsa-miR-500:PITA TOP PITA 4.166E-4 3.837E-2
2.800E-1
3.453E-1
 5 325
Show 4 more annotations

17: Drug [Display Chart] 7308 annotations before applied cutoff / 22098 genes in category

No results to display

18: Disease [Display Chart] 796 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0030848 Peyronie Disease DisGeNET Curated 1.627E-4 4.540E-2
3.295E-1
1.295E-1
 2 9
2 umls:C0020500 Hyperoxaluria DisGeNET Curated 4.707E-4 4.540E-2
3.295E-1
3.747E-1
 2 15
3 umls:C0432409 Trisomy 11 DisGeNET BeFree 4.707E-4 4.540E-2
3.295E-1
3.747E-1
 2 15
4 umls:C0598798 Lymphoid neoplasm DisGeNET BeFree 1.122E-3 4.540E-2
3.295E-1
8.930E-1
 2 23
5 umls:C1265996 Large cell neuroendocrine carcinoma DisGeNET BeFree 1.911E-3 4.540E-2
3.295E-1
1.000E0
 2 30
6 umls:C0220726 Diastrophic dysplasia DisGeNET Curated 2.040E-3 4.540E-2
3.295E-1
1.000E0
 2 31
7 umls:C1333990 Hereditary Nonpolyposis Colorectal Cancer DisGeNET Curated 2.099E-3 4.540E-2
3.295E-1
1.000E0
 3 118
8 cv:C1857034 Ehlers-Danlos syndrome, autosomal recessive, cardiac valvular form Clinical Variations 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
9 cv:CN218525 Nanophthalmos 4 Clinical Variations 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
10 umls:C1857034 Ehlers-Danlos syndrome, cardiac valvular form DisGeNET Curated 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
11 umls:C1848578 METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA, cblF TYPE (disorder) DisGeNET Curated 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
12 cv:C1843898 Body mass index quantitative trait locus 4 Clinical Variations 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
13 umls:C4014848 NANOPHTHALMOS 4 DisGeNET Curated 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
14 umls:C1332304 Anterior Tongue Carcinoma DisGeNET BeFree 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
15 cv:C1848578 METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA, cblF TYPE Clinical Variations 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
16 cv:C1963674 Spinocerebellar ataxia 10 Clinical Variations 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
17 umls:C2937359 Old thrombus DisGeNET BeFree 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
18 cv:C1863485 Acetyl-CoA acetyltransferase-2 deficiency Clinical Variations 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
19 601238 CEREBELLAR ATAXIA, CAYMAN TYPE; ATCAY OMIM 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
20 cv:CN189149 Mental retardation, autosomal dominant 27 Clinical Variations 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
21 cv:C0268126 Adenylosuccinate lyase deficiency Clinical Variations 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
22 607447 BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 4; BMIQ4 OMIM 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
23 umls:C0268356 Osteogenesis imperfecta with blue sclerae AND normal teeth DisGeNET BeFree 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
24 103050 ADENYLOSUCCINASE DEFICIENCY OMIM 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
25 277380 METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA, cblF TYPE OMIM 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
26 umls:C1843898 BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 4 (disorder) DisGeNET Curated 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
27 cv:C1832585 Cerebellar ataxia, cayman type Clinical Variations 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
28 umls:C0545081 mantle lymphoma DisGeNET BeFree 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
29 umls:C0855070 Synovial sarcoma metastatic DisGeNET BeFree 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
30 225320 EHLERS-DANLOS SYNDROME, AUTOSOMAL RECESSIVE, CARDIAC VALVULAR FORM OMIM 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
31 cv:CN180044 Cortical dysplasia, complex, with other brain malformations 2 Clinical Variations 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
32 umls:C1851801 EDS VIIB DisGeNET Curated 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
33 603516 SPINOCEREBELLAR ATAXIA 10; SCA10 OMIM 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
34 umls:C1832585 CEREBELLAR ATAXIA, CAYMAN TYPE DisGeNET Curated 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
35 umls:C4014528 MENTAL RETARDATION, AUTOSOMAL DOMINANT 27 DisGeNET Curated 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
36 umls:C0036310 Scheuermann's Disease DisGeNET BeFree 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
37 umls:C1333786 Gastric Precancerous Condition DisGeNET BeFree 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
38 umls:C3809013 CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 2 DisGeNET Curated 2.167E-3 4.540E-2
3.295E-1
1.000E0
 1 1
39 umls:C1402294 Primary Lesion DisGeNET BeFree 2.310E-3 4.714E-2
3.421E-1
1.000E0
 2 33
40 umls:C1306214 ACTH-Secreting Pituitary Adenoma DisGeNET Curated 2.596E-3 4.721E-2
3.426E-1
1.000E0
 2 35
41 umls:C3536893 Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor DisGeNET BeFree 2.596E-3 4.721E-2
3.426E-1
1.000E0
 2 35
42 umls:C0206630 Endometrial Stromal Sarcoma DisGeNET Curated 3.215E-3 4.721E-2
3.426E-1
1.000E0
 2 39
43 umls:C0024667 Animal Mammary Neoplasms DisGeNET Curated 3.271E-3 4.721E-2
3.426E-1
1.000E0
 3 138
44 umls:C0023484 Leukemia, Plasma Cell DisGeNET BeFree 3.548E-3 4.721E-2
3.426E-1
1.000E0
 2 41
45 umls:C0029434 Osteogenesis Imperfecta DisGeNET Curated 4.077E-3 4.721E-2
3.426E-1
1.000E0
 2 44
46 umls:C0023532 Leukoplakia, Oral DisGeNET Curated 4.077E-3 4.721E-2
3.426E-1
1.000E0
 2 44
47 umls:C0010823 Cytomegalovirus Infections DisGeNET Curated 4.212E-3 4.721E-2
3.426E-1
1.000E0
 3 151
48 umls:C0024668 Mammary Neoplasms, Experimental DisGeNET Curated 4.290E-3 4.721E-2
3.426E-1
1.000E0
 3 152
49 cv:C0026764 Multiple myeloma Clinical Variations 4.330E-3 4.721E-2
3.426E-1
1.000E0
 1 2
50 umls:C0003463 Anus Neoplasms DisGeNET Curated 4.330E-3 4.721E-2
3.426E-1
1.000E0
 1 2
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