Toppgene analysis for aggregated_1964_log, IC26, negative side

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1: GO: Molecular Function [Display Chart] 390 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004332 fructose-bisphosphate aldolase activity 5.074E-5 1.979E-2
1.295E-1
 1.979E-2 2 3
2 GO:0043184 vascular endothelial growth factor receptor 2 binding 3.514E-4 4.857E-2
3.179E-1
1.370E-1
 2 7
3 GO:0005158 insulin receptor binding 3.736E-4 4.857E-2
3.179E-1
1.457E-1
 3 34

2: GO: Biological Process [Display Chart] 2525 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0070482 response to oxygen levels 1.819E-9 4.592E-6 3.862E-5 4.592E-6 13 339
2 GO:0036293 response to decreased oxygen levels 1.114E-8 1.407E-5 1.183E-4 2.814E-5 12 322
3 GO:0061718 glucose catabolic process to pyruvate 7.568E-8 3.481E-5 2.928E-4 1.911E-4 5 26
4 GO:0061621 canonical glycolysis 7.568E-8 3.481E-5 2.928E-4 1.911E-4 5 26
5 GO:0006735 NADH regeneration 7.568E-8 3.481E-5 2.928E-4 1.911E-4 5 26
6 GO:0001666 response to hypoxia 8.693E-8 3.481E-5 2.928E-4 2.195E-4 11 313
7 GO:0045766 positive regulation of angiogenesis 9.651E-8 3.481E-5 2.928E-4 2.437E-4 8 133
8 GO:0061620 glycolytic process through glucose-6-phosphate 1.353E-7 4.270E-5 3.591E-4 3.416E-4 5 29
9 GO:0061615 glycolytic process through fructose-6-phosphate 1.618E-7 4.539E-5 3.818E-4 4.085E-4 5 30
10 GO:1904018 positive regulation of vasculature development 2.321E-7 5.861E-5 4.930E-4 5.861E-4 8 149
11 GO:0006007 glucose catabolic process 2.668E-7 6.124E-5 5.151E-4 6.736E-4 5 33
12 GO:0071453 cellular response to oxygen levels 3.818E-7 8.034E-5 6.758E-4 9.641E-4 8 159
13 GO:0001525 angiogenesis 6.025E-7 1.170E-4 9.843E-4 1.521E-3 12 465
14 GO:0045765 regulation of angiogenesis 7.947E-7 1.433E-4 1.206E-3 2.007E-3 9 239
15 GO:0050679 positive regulation of epithelial cell proliferation 8.626E-7 1.452E-4 1.221E-3 2.178E-3 8 177
16 GO:0006734 NADH metabolic process 1.047E-6 1.652E-4 1.389E-3 2.643E-3 5 43
17 GO:1900084 regulation of peptidyl-tyrosine autophosphorylation 1.474E-6 2.189E-4 1.841E-3 3.722E-3 3 6
18 GO:0046031 ADP metabolic process 1.650E-6 2.315E-4 1.947E-3 4.167E-3 6 85
19 GO:1901342 regulation of vasculature development 1.813E-6 2.409E-4 2.026E-3 4.577E-3 9 264
20 GO:0006165 nucleoside diphosphate phosphorylation 3.170E-6 3.986E-4 3.353E-3 8.005E-3 6 95
21 GO:0019320 hexose catabolic process 3.315E-6 3.986E-4 3.353E-3 8.370E-3 5 54
22 GO:0036294 cellular response to decreased oxygen levels 3.668E-6 4.209E-4 3.541E-3 9.261E-3 7 151
23 GO:0009179 purine ribonucleoside diphosphate metabolic process 4.530E-6 4.766E-4 4.009E-3 1.144E-2 6 101
24 GO:0009135 purine nucleoside diphosphate metabolic process 4.530E-6 4.766E-4 4.009E-3 1.144E-2 6 101
25 GO:0046939 nucleotide phosphorylation 4.797E-6 4.845E-4 4.076E-3 1.211E-2 6 102
26 GO:0051260 protein homooligomerization 5.149E-6 5.001E-4 4.206E-3 1.300E-2 9 300
27 GO:0009185 ribonucleoside diphosphate metabolic process 5.996E-6 5.607E-4 4.717E-3 1.514E-2 6 106
28 GO:0019674 NAD metabolic process 7.150E-6 6.448E-4 5.424E-3 1.805E-2 5 63
29 GO:0045428 regulation of nitric oxide biosynthetic process 7.731E-6 6.507E-4 5.473E-3 1.952E-2 5 64
30 GO:0046365 monosaccharide catabolic process 7.731E-6 6.507E-4 5.473E-3 1.952E-2 5 64
31 GO:0006090 pyruvate metabolic process 8.673E-6 7.065E-4 5.942E-3 2.190E-2 6 113
32 GO:0048747 muscle fiber development 9.001E-6 7.103E-4 5.974E-3 2.273E-2 5 66
33 GO:2000377 regulation of reactive oxygen species metabolic process 1.081E-5 8.275E-4 6.960E-3 2.731E-2 7 178
34 GO:0046718 viral entry into host cell 1.225E-5 8.479E-4 7.132E-3 3.092E-2 6 120
35 GO:0001938 positive regulation of endothelial cell proliferation 1.290E-5 8.479E-4 7.132E-3 3.257E-2 5 71
36 GO:0055001 muscle cell development 1.295E-5 8.479E-4 7.132E-3 3.270E-2 7 183
37 GO:0052126 movement in host environment 1.410E-5 8.479E-4 7.132E-3 3.561E-2 6 123
38 GO:0051828 entry into other organism involved in symbiotic interaction 1.410E-5 8.479E-4 7.132E-3 3.561E-2 6 123
39 GO:0052192 movement in environment of other organism involved in symbiotic interaction 1.410E-5 8.479E-4 7.132E-3 3.561E-2 6 123
40 GO:0044409 entry into host 1.410E-5 8.479E-4 7.132E-3 3.561E-2 6 123
41 GO:0030260 entry into host cell 1.410E-5 8.479E-4 7.132E-3 3.561E-2 6 123
42 GO:0051806 entry into cell of other organism involved in symbiotic interaction 1.410E-5 8.479E-4 7.132E-3 3.561E-2 6 123
43 GO:0009132 nucleoside diphosphate metabolic process 1.618E-5 9.502E-4 7.993E-3 4.086E-2 6 126
44 GO:0006809 nitric oxide biosynthetic process 1.687E-5 9.682E-4 8.144E-3 4.260E-2 5 75
45 GO:0032868 response to insulin 1.796E-5 9.880E-4 8.311E-3 4.535E-2 8 267
46 GO:0006096 glycolytic process 1.800E-5 9.880E-4 8.311E-3 4.545E-2 5 76
47 GO:0006757 ATP generation from ADP 1.919E-5 1.031E-3 8.670E-3 4.844E-2 5 77
48 GO:0046209 nitric oxide metabolic process 2.174E-5 1.144E-3 9.620E-3
5.489E-2
 5 79
49 GO:1903426 regulation of reactive oxygen species biosynthetic process 2.764E-5 1.396E-3 1.174E-2
6.979E-2
 5 83
50 GO:2001057 reactive nitrogen species metabolic process 2.764E-5 1.396E-3 1.174E-2
6.979E-2
 5 83
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 227 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043209 myelin sheath 2.106E-4 1.658E-2
9.953E-2
 4.781E-2 6 204
2 GO:0030141 secretory granule 2.661E-4 1.658E-2
9.953E-2
6.041E-2
 8 401
3 GO:0043204 perikaryon 3.410E-4 1.658E-2
9.953E-2
7.740E-2
 5 144
4 GO:0030135 coated vesicle 5.127E-4 1.658E-2
9.953E-2
1.164E-1
 6 241
5 GO:0016323 basolateral plasma membrane 5.591E-4 1.658E-2
9.953E-2
1.269E-1
 6 245
6 GO:0098857 membrane microdomain 5.726E-4 1.658E-2
9.953E-2
1.300E-1
 7 343
7 GO:0045121 membrane raft 5.726E-4 1.658E-2
9.953E-2
1.300E-1
 7 343
8 GO:0030136 clathrin-coated vesicle 5.842E-4 1.658E-2
9.953E-2
1.326E-1
 5 162
9 GO:0030055 cell-substrate junction 1.464E-3 3.691E-2
2.217E-1
3.322E-1
 7 403
10 GO:0031045 dense core granule 1.987E-3 4.306E-2
2.585E-1
4.510E-1
 2 16
11 GO:0045177 apical part of cell 2.086E-3 4.306E-2
2.585E-1
4.736E-1
 7 429
12 GO:0031674 I band 2.526E-3 4.467E-2
2.682E-1
5.733E-1
 4 136
13 GO:0005811 lipid particle 2.766E-3 4.467E-2
2.682E-1
6.278E-1
 3 67
14 GO:0045334 clathrin-coated endocytic vesicle 2.885E-3 4.467E-2
2.682E-1
6.549E-1
 3 68
15 GO:0030662 coated vesicle membrane 2.951E-3 4.467E-2
2.682E-1
6.700E-1
 4 142
Show 10 more annotations

4: Human Phenotype [Display Chart] 314 annotations before applied cutoff / 4410 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 2137 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002972 abnormal cardiac muscle contractility 1.176E-5 1.377E-2
1.135E-1
 2.514E-2 10 284
2 MP:0005140 decreased cardiac muscle contractility 1.677E-5 1.377E-2
1.135E-1
 3.583E-2 9 234
3 MP:0003921 abnormal heart left ventricle morphology 2.733E-5 1.377E-2
1.135E-1
5.841E-2
 10 313
4 MP:0005620 abnormal muscle contractility 3.965E-5 1.377E-2
1.135E-1
8.474E-2
 11 398
5 MP:0005023 abnormal wound healing 4.045E-5 1.377E-2
1.135E-1
8.644E-2
 8 201
6 MP:0004564 enlarged myocardial fiber 4.608E-5 1.377E-2
1.135E-1
9.848E-2
 5 62
7 MP:0000249 abnormal blood vessel physiology 5.201E-5 1.377E-2
1.135E-1
1.112E-1
 11 410
8 MP:0004215 abnormal myocardial fiber physiology 6.493E-5 1.377E-2
1.135E-1
1.387E-1
 7 158
9 MP:0002658 abnormal liver regeneration 7.062E-5 1.377E-2
1.135E-1
1.509E-1
 4 35
10 MP:0000278 abnormal myocardial fiber morphology 7.191E-5 1.377E-2
1.135E-1
1.537E-1
 8 218
11 MP:0004087 abnormal muscle fiber morphology 7.514E-5 1.377E-2
1.135E-1
1.606E-1
 11 427
12 MP:0004883 abnormal vascular wound healing 7.732E-5 1.377E-2
1.135E-1
1.652E-1
 5 69
13 MP:0003221 abnormal cardiomyocyte apoptosis 1.153E-4 1.895E-2
1.563E-1
2.464E-1
 5 75
14 MP:0003141 cardiac fibrosis 1.577E-4 2.294E-2
1.891E-1
3.371E-1
 7 182
15 MP:0000738 impaired muscle contractility 1.610E-4 2.294E-2
1.891E-1
3.441E-1
 9 313
16 MP:0006190 retinal ischemia 2.436E-4 3.099E-2
2.555E-1
5.206E-1
 2 4
17 MP:0001179 thick pulmonary interalveolar septum 2.465E-4 3.099E-2
2.555E-1
5.268E-1
 4 48
18 MP:0012106 impaired exercise endurance 3.893E-4 4.622E-2
3.810E-1
8.319E-1
 4 54
Show 13 more annotations

6: Domain [Display Chart] 598 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF06553 BNIP3 Pfam 1.801E-5 3.221E-3 2.246E-2 1.077E-2 2 2
2 IPR010548 BNIP3 InterPro 1.801E-5 3.221E-3 2.246E-2 1.077E-2 2 2
3 PS00158 ALDOLASE CLASS I PROSITE 5.387E-5 3.221E-3 2.246E-2 3.221E-2 2 3
4 IPR029768 Aldolase I AS InterPro 5.387E-5 3.221E-3 2.246E-2 3.221E-2 2 3
5 PF01146 Caveolin Pfam 5.387E-5 3.221E-3 2.246E-2 3.221E-2 2 3
6 PF00274 Glycolytic Pfam 5.387E-5 3.221E-3 2.246E-2 3.221E-2 2 3
7 IPR018361 Caveolin CS InterPro 5.387E-5 3.221E-3 2.246E-2 3.221E-2 2 3
8 IPR000741 FBA I InterPro 5.387E-5 3.221E-3 2.246E-2 3.221E-2 2 3
9 IPR001612 Caveolin InterPro 5.387E-5 3.221E-3 2.246E-2 3.221E-2 2 3
10 PS01210 CAVEOLIN PROSITE 5.387E-5 3.221E-3 2.246E-2 3.221E-2 2 3
11 IPR003645 Fol N InterPro 9.659E-4 4.814E-2
3.356E-1
5.776E-1
 2 11
12 SM00274 FOLN SMART 9.659E-4 4.814E-2
3.356E-1
5.776E-1
 2 11
13 IPR033306 CAV-2 InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
14 IPR022699 Stonin2 N InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
15 IPR027006 SYTL2 InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
16 PS00884 OSTEOPONTIN PROSITE 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
17 IPR015504 CAV-1 InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
18 IPR027697 NF-M InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
19 IPR019832 Mn/Fe SOD C InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
20 IPR028585 AK4 mitochondrial InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
21 IPR013294 LBH InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
22 IPR028540 AKAP12 InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
23 SM00017 OSTEO SMART 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
24 PF12016 Stonin2 N Pfam 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
25 IPR030472 Tissue Factor CS InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
26 IPR019833 Mn/Fe SOD BS InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
27 IPR002439 Glu transpt 1 InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
28 2.10.160.10 - Gene3D 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
29 IPR027303 Gln synth gly rich site InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
30 IPR033598 WBP2 InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
31 IPR027928 VEGF C InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
32 IPR026190 Hipoxia HILPDA InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
33 IPR033197 DDAH1 InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
34 IPR016359 SPARC-like p1 InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
35 IPR019841 Osteopontin CS InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
36 IPR031210 FKBP5 InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
37 PF00081 Sod Fe N Pfam 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
38 PS00621 TISSUE FACTOR PROSITE 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
39 IPR027302 Gln synth N conserv site InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
40 IPR031217 Noelin InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
41 PF15220 HILPDA Pfam 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
42 PF02777 Sod Fe C Pfam 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
43 PS00088 SOD MN PROSITE 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
44 IPR020776 Tyr kinase non-rcpt Jak1 InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
45 PF00865 Osteopontin Pfam 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
46 IPR001710 Adrenomedullin InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
47 IPR019831 Mn/Fe SOD N InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
48 IPR003548 Claudin1 InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
49 PF14554 VEGF C Pfam 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
50 IPR031228 STON2 InterPro 4.270E-3 4.854E-2
3.384E-1
1.000E0
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 705 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 782396 glycolysis BioSystems: BIOCYC 1.450E-8 9.544E-6 6.811E-5 1.022E-5 5 17
2 138045 HIF-1-alpha transcription factor network BioSystems: Pathway Interaction Database 2.708E-8 9.544E-6 6.811E-5 1.909E-5 7 65
3 695200 HIF-1 signaling pathway BioSystems: KEGG 4.352E-8 1.023E-5 7.298E-5 3.068E-5 8 106
4 413340 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate BioSystems: KEGG 1.208E-7 1.845E-5 1.316E-4 8.517E-5 5 25
5 198814 Glycolysis and Gluconeogenesis BioSystems: WikiPathways 1.308E-7 1.845E-5 1.316E-4 9.223E-5 6 49
6 105911 Glycolysis BioSystems: REACTOME 2.660E-7 3.125E-5 2.230E-4 1.875E-4 5 29
7 782382 gluconeogenesis BioSystems: BIOCYC 9.315E-7 7.422E-5 5.297E-4 6.567E-4 4 16
8 MAP00710 Carbon fixation MAP00710 Carbon fixation GenMAPP 9.315E-7 7.422E-5 5.297E-4 6.567E-4 4 16
9 835393 conversion of glucose to acetyl CoA and entry into the TCA cycle BioSystems: BIOCYC 9.475E-7 7.422E-5 5.297E-4 6.680E-4 5 37
10 413342 Gluconeogenesis, oxaloacetate => fructose-6P BioSystems: KEGG 1.214E-6 8.556E-5 6.106E-4 8.556E-4 4 17
11 790012 Biosynthesis of amino acids BioSystems: KEGG 1.455E-6 9.322E-5 6.652E-4 1.025E-3 6 73
12 P00024 Glycolysis PantherDB 2.265E-6 1.331E-4 9.496E-4 1.597E-3 3 6
13 PW:0000640 glycolysis pathway Pathway Ontology 3.007E-6 1.631E-4 1.164E-3 2.120E-3 4 21
14 MAP00010 Glycolysis Gluconeogenesis MAP00010 Glycolysis Gluconeogenesis GenMAPP 5.341E-6 2.690E-4 1.919E-3 3.765E-3 5 52
15 82926 Glycolysis / Gluconeogenesis BioSystems: KEGG 1.743E-5 8.191E-4 5.845E-3 1.229E-2 5 66
16 106204 Gluconeogenesis BioSystems: REACTOME 1.968E-5 8.670E-4 6.187E-3 1.387E-2 4 33
17 413341 Glycolysis, core module involving three-carbon compounds BioSystems: KEGG 2.440E-5 1.012E-3 7.220E-3 1.720E-2 3 12
18 SMP00040 Glycolysis SMPDB 3.160E-5 1.147E-3 8.186E-3 2.228E-2 3 13
19 PW:0000057 carbon fixation Pathway Ontology 3.160E-5 1.147E-3 8.186E-3 2.228E-2 3 13
20 106199 Glucose metabolism BioSystems: REACTOME 3.254E-5 1.147E-3 8.186E-3 2.294E-2 5 75
21 137939 Direct p53 effectors BioSystems: Pathway Interaction Database 4.871E-5 1.635E-3 1.167E-2 3.434E-2 6 134
22 PW:0000641 gluconeogenesis pathway Pathway Ontology 7.409E-5 2.374E-3 1.694E-2
5.224E-2
 3 17
23 814926 Carbon metabolism BioSystems: KEGG 9.161E-5 2.808E-3 2.004E-2
6.459E-2
 5 93
24 198828 Hypertrophy Model BioSystems: WikiPathways 1.229E-4 3.611E-3 2.577E-2
8.666E-2
 3 20
25 106532 Neurotransmitter uptake and Metabolism In Glial Cells BioSystems: REACTOME 1.432E-4 3.883E-3 2.771E-2
1.010E-1
 2 4
26 106533 Astrocytic Glutamate-Glutamine Uptake And Metabolism BioSystems: REACTOME 1.432E-4 3.883E-3 2.771E-2
1.010E-1
 2 4
27 PW:0000143 insulin signaling Pathway Ontology 3.078E-4 7.749E-3
5.530E-2
2.170E-1
 3 27
28 M1718 Genes related to IL4 rceptor signaling in B lymphocytes MSigDB C2 BIOCARTA (v5.1) 3.078E-4 7.749E-3
5.530E-2
2.170E-1
 3 27
29 545347 sucrose degradation V (mammalian) BioSystems: BIOCYC 3.558E-4 8.649E-3
6.172E-2
2.508E-1
 2 6
30 PW:0000025 glycolysis/gluconeogenesis Pathway Ontology 3.818E-4 8.972E-3
6.402E-2
2.691E-1
 3 29
31 M1909 EGF Signaling Pathway MSigDB C2 BIOCARTA (v5.1) 4.664E-4 1.061E-2
7.569E-2
3.288E-1
 3 31
32 P02744 Fructose galactose metabolism PantherDB 4.965E-4 1.089E-2
7.775E-2
3.500E-1
 2 7
33 83067 Focal adhesion BioSystems: KEGG 5.100E-4 1.089E-2
7.775E-2
3.595E-1
 6 206
34 137956 HIF-2-alpha transcription factor network BioSystems: Pathway Interaction Database 6.144E-4 1.274E-2
9.091E-2
4.331E-1
 3 34
35 169350 Signaling events mediated by TCPTP BioSystems: Pathway Interaction Database 7.280E-4 1.466E-2
1.046E-1
5.132E-1
 3 36
36 782000 Proteoglycans in cancer BioSystems: KEGG 8.110E-4 1.544E-2
1.102E-1
5.718E-1
 6 225
37 P00005 Angiogenesis PantherDB 8.429E-4 1.544E-2
1.102E-1
5.943E-1
 5 150
38 645296 EGFR Transactivation by Gastrin BioSystems: REACTOME 8.457E-4 1.544E-2
1.102E-1
5.962E-1
 2 9
39 83115 Bladder cancer BioSystems: KEGG 8.541E-4 1.544E-2
1.102E-1
6.022E-1
 3 38
40 PW:0000498 reverse cholesterol transport Pathway Ontology 1.054E-3 1.857E-2
1.325E-1
7.429E-1
 2 10
41 198845 Insulin Signaling BioSystems: WikiPathways 1.223E-3 2.104E-2
1.501E-1
8.625E-1
 5 163
42 198857 IL-7 Signaling Pathway BioSystems: WikiPathways 1.313E-3 2.204E-2
1.573E-1
9.258E-1
 3 44
43 799177 Estrogen signaling pathway BioSystems: KEGG 1.476E-3 2.420E-2
1.727E-1
1.000E0
 4 100
44 530762 Interleukin-7 signaling BioSystems: REACTOME 1.536E-3 2.461E-2
1.756E-1
1.000E0
 2 12
45 198782 EGFR1 Signaling Pathway BioSystems: WikiPathways 1.762E-3 2.760E-2
1.970E-1
1.000E0
 5 177
46 M16973 CBL mediated ligand-induced downregulation of EGF receptors MSigDB C2 BIOCARTA (v5.1) 1.809E-3 2.773E-2
1.979E-1
1.000E0
 2 13
47 106196 Metabolism of carbohydrates BioSystems: REACTOME 1.917E-3 2.875E-2
2.052E-1
1.000E0
 6 266
48 138016 ErbB receptor signaling network BioSystems: Pathway Interaction Database 2.104E-3 3.005E-2
2.144E-1
1.000E0
 2 14
49 PW:0000045 pentose phosphate Pathway Ontology 2.104E-3 3.005E-2
2.144E-1
1.000E0
 2 14
50 137976 IL2-mediated signaling events BioSystems: Pathway Interaction Database 2.131E-3 3.005E-2
2.144E-1
1.000E0
 3 52
Show 45 more annotations

8: Pubmed [Display Chart] 31026 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20381070 Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia. Pubmed 4.100E-11 6.360E-7 6.945E-6 1.272E-6 6 40
2 20381070:gr Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia. GeneRIF 4.100E-11 6.360E-7 6.945E-6 1.272E-6 6 40
3 25241761 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. Pubmed 6.614E-9 6.840E-5 7.470E-4 2.052E-4 9 371
4 25963717 mRNA expression levels of hypoxia-induced and stem cell-associated genes in human glioblastoma. Pubmed 3.528E-8 2.737E-4 2.988E-3 1.095E-3 3 5
5 20029029 Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Pubmed 1.914E-7 4.767E-4 5.205E-3 5.939E-3 5 82
6 20416077:gr Identification of type 2 diabetes-associated combination of SNPs using support vector machine. GeneRIF 3.227E-7 4.767E-4 5.205E-3 1.001E-2 5 91
7 20416077 Identification of type 2 diabetes-associated combination of SNPs using support vector machine. Pubmed 3.227E-7 4.767E-4 5.205E-3 1.001E-2 5 91
8 20346360 Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. Pubmed 3.795E-7 4.767E-4 5.205E-3 1.178E-2 5 94
9 20346360:gr Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. GeneRIF 3.795E-7 4.767E-4 5.205E-3 1.178E-2 5 94
10 15588985 Substrate-trapping techniques in the identification of cellular PTP targets. Pubmed 1.146E-6 4.767E-4 5.205E-3 3.555E-2 4 50
11 19948975:gr Integrative predictive model of coronary artery calcification in atherosclerosis. GeneRIF 1.589E-6 4.767E-4 5.205E-3 4.931E-2 6 229
12 19948975 Integrative predictive model of coronary artery calcification in atherosclerosis. Pubmed 1.589E-6 4.767E-4 5.205E-3 4.931E-2 6 229
13 19625176 PTEN identified as important risk factor of chronic obstructive pulmonary disease. Pubmed 2.010E-6 4.767E-4 5.205E-3
6.236E-2
 7 376
14 19625176:gr PTEN identified as important risk factor of chronic obstructive pulmonary disease. GeneRIF 2.010E-6 4.767E-4 5.205E-3
6.236E-2
 7 376
15 15952740 Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. Pubmed 2.091E-6 4.767E-4 5.205E-3
6.488E-2
 4 58
16 18676680 Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. Pubmed 2.193E-6 4.767E-4 5.205E-3
6.804E-2
 7 381
17 18676680:gr Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. GeneRIF 2.193E-6 4.767E-4 5.205E-3
6.804E-2
 7 381
18 19170196 Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. Pubmed 2.270E-6 4.767E-4 5.205E-3
7.042E-2
 7 383
19 19170196:gr Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. GeneRIF 2.270E-6 4.767E-4 5.205E-3
7.042E-2
 7 383
20 20400478 Polymorphisms in EGFR and VEGF contribute to non-small-cell lung cancer survival in a Chinese population. Pubmed 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
21 21867616 [Expression of osteopontin and VEGF in acute leukemia and their relationship with angiogenesis]. Pubmed 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
22 24811984 Patient genotypes impact survival after surgery for isolated congenital heart disease. Pubmed 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
23 17623653:gr Mitochondrial proteins Bnip3 and Bnip3L are involved in anthrax lethal toxin-induced macrophage cell death. GeneRIF 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
24 12606946:gr Osteopontin-induced migration of human mammary epithelial cells involves activation of EGF receptor and multiple signal transduction pathways. GeneRIF 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
25 16219518 Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome. Pubmed 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
26 16105029:gr High glucose transactivates the EGF receptor and up-regulates serum glucocorticoid kinase in the proximal tubule. GeneRIF 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
27 18317076 Increased vascular-endothelial growth factor (VEGF) tumor expression and response to epidermal growth factor receptor (EGF-R) inhibitor erlotinib in non-small cell lung cancer (NSCLC). Pubmed 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
28 11921018:gr Expression of tissue factor and vascular endothelial growth factor is associated with angiogenesis in colorectal cancer. GeneRIF 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
29 19628492:gr Polymorphism of the manganese superoxide dismutase gene but not of vascular endothelial growth factor gene is a risk factor for diabetic retinopathy. GeneRIF 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
30 18227718 Expression of Glut-1 and Claudin-1 in follicular dendritic cell sarcoma. Pubmed 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
31 18835104:gr Pulmonary tumor thrombotic microangiopathy caused by an ovarian cancer expressing tissue factor and vascular endothelial growth factor. GeneRIF 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
32 25071074 Expression characteristics of KAI1 and vascular endothelial growth factor and their diagnostic value for hepatocellular carcinoma. Pubmed 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
33 19369471 The hypoxic synovial environment regulates expression of vascular endothelial growth factor and osteopontin in juvenile idiopathic arthritis. Pubmed 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
34 22475893:gr The relationship between GLUT-1 and vascular endothelial growth factor expression and 18F-FDG uptake in esophageal squamous cell cancer patients. GeneRIF 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
35 16443776:gr SGK1 kinase upregulates GLUT1 activity and plasma membrane expression. GeneRIF 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
36 18083119:gr Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetic mice. GeneRIF 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
37 19234131:gr Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR. GeneRIF 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
38 11921018 Expression of tissue factor and vascular endothelial growth factor is associated with angiogenesis in colorectal cancer. Pubmed 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
39 18087285 Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma. Pubmed 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
40 21867616:gr [Expression of osteopontin and VEGF in acute leukemia and their relationship with angiogenesis]. GeneRIF 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
41 10985391 Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1. Pubmed 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
42 19891976:gr Change in P-glycoprotein and caveolin protein expression in brain striatum capillaries in New Zealand obese mice with type 2 diabetes. GeneRIF 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
43 21968684 Expression of aquaporin-4 in human supratentorial meningiomas with peritumoral brain edema and correlation of VEGF with edema formation. Pubmed 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
44 22178239:gr Adrenomedullin interacts with VEGF in endometrial cancer and has varied modulation in tumours of different grades. GeneRIF 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
45 25912843 Pubmed 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
46 23302311:gr [Clinicopathologic features and expression of epidermal growth factor receptor and vascular endothelial growth factor in adrenocortical tumors]. GeneRIF 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
47 12354760 Ganglioside induces caveolin-1 redistribution and interaction with the epidermal growth factor receptor. Pubmed 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
48 18450321:gr Correlation of EGFR mutations with chromosomal alterations and expression of EGFR, ErbB3 and VEGF in tumor samples of lung adenocarcinoma patients. GeneRIF 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
49 19273585:gr Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. GeneRIF 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
50 15968725 High expressions of caveolins on the proliferating bile ductules in primary biliary cirrhosis. Pubmed 2.351E-6 4.767E-4 5.205E-3
7.293E-2
 2 2
Show 45 more annotations

9: Interaction [Display Chart] 2523 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PLD2 PLD2 interactions 1.623E-6 3.673E-3 3.089E-2 4.094E-3 5 42
2 int:KCNMA1 KCNMA1 interactions 2.911E-6 3.673E-3 3.089E-2 7.345E-3 8 186
3 int:CD44 CD44 interactions 1.938E-5 1.116E-2
9.384E-2
 4.891E-2 5 69
4 int:ALDOA ALDOA interactions 2.114E-5 1.116E-2
9.384E-2
5.334E-2
 6 118
5 int:GRK2 GRK2 interactions 2.387E-5 1.116E-2
9.384E-2
6.021E-2
 5 72
6 int:HBEGF HBEGF interactions 2.901E-5 1.116E-2
9.384E-2
7.319E-2
 3 13
7 int:FES FES interactions 3.149E-5 1.116E-2
9.384E-2
7.946E-2
 4 38
8 int:GPX4 GPX4 interactions 3.871E-5 1.116E-2
9.384E-2
9.766E-2
 4 40
9 int:FH FH interactions 3.980E-5 1.116E-2
9.384E-2
1.004E-1
 5 80
10 int:CAV2 CAV2 interactions 4.583E-5 1.156E-2
9.726E-2
1.156E-1
 3 15
11 int:LBH LBH interactions 6.742E-5 1.349E-2
1.135E-1
1.701E-1
 2 3
12 int:ENO3 ENO3 interactions 7.366E-5 1.349E-2
1.135E-1
1.858E-1
 4 47
13 int:PGK1 PGK1 interactions 8.199E-5 1.349E-2
1.135E-1
2.068E-1
 5 93
14 int:PTRF PTRF interactions 8.687E-5 1.349E-2
1.135E-1
2.192E-1
 4 49
15 int:IRS1 IRS1 interactions 9.072E-5 1.349E-2
1.135E-1
2.289E-1
 5 95
16 int:ITGB2 ITGB2 interactions 9.408E-5 1.349E-2
1.135E-1
2.374E-1
 4 50
17 int:ADI1 ADI1 interactions 9.627E-5 1.349E-2
1.135E-1
2.429E-1
 3 19
18 int:CFH CFH interactions 9.627E-5 1.349E-2
1.135E-1
2.429E-1
 3 19
19 int:PTPRF PTPRF interactions 1.017E-4 1.351E-2
1.136E-1
2.566E-1
 4 51
20 int:TGM2 TGM2 interactions 1.213E-4 1.530E-2
1.287E-1
3.060E-1
 5 101
21 int:TAGLN TAGLN interactions 1.368E-4 1.644E-2
1.383E-1
3.452E-1
 4 55
22 int:FKBP7 FKBP7 interactions 1.736E-4 1.974E-2
1.660E-1
4.379E-1
 3 23
23 int:IRS2 IRS2 interactions 1.800E-4 1.974E-2
1.660E-1
4.541E-1
 4 59
24 int:PFKM PFKM interactions 1.921E-4 1.990E-2
1.674E-1
4.847E-1
 4 60
25 int:TINF2 TINF2 interactions 1.972E-4 1.990E-2
1.674E-1
4.975E-1
 5 112
26 int:SPARCL1 SPARCL1 interactions 2.233E-4 2.167E-2
1.823E-1
5.635E-1
 2 5
27 int:STXBP1 STXBP1 interactions 2.467E-4 2.306E-2
1.939E-1
6.225E-1
 4 64
28 int:TRAF3IP1 TRAF3IP1 interactions 2.944E-4 2.653E-2
2.231E-1
7.429E-1
 4 67
29 int:HSD17B10 HSD17B10 interactions 3.049E-4 2.653E-2
2.231E-1
7.693E-1
 5 123
30 int:DISC1 DISC1 interactions 3.165E-4 2.662E-2
2.239E-1
7.986E-1
 5 124
31 int:ALDOC ALDOC interactions 3.484E-4 2.766E-2
2.326E-1
8.791E-1
 4 70
32 int:HABP4 HABP4 interactions 3.508E-4 2.766E-2
2.326E-1
8.850E-1
 3 29
33 int:TKT TKT interactions 4.222E-4 3.228E-2
2.715E-1
1.000E0
 5 132
34 int:DUT DUT interactions 4.536E-4 3.366E-2
2.831E-1
1.000E0
 4 75
35 int:ACO2 ACO2 interactions 4.712E-4 3.397E-2
2.857E-1
1.000E0
 3 32
36 int:SUMO4 SUMO4 interactions 5.797E-4 4.015E-2
3.377E-1
1.000E0
 4 80
37 int:STIP1 STIP1 interactions 5.893E-4 4.015E-2
3.377E-1
1.000E0
 5 142
38 int:GAPDH GAPDH interactions 6.119E-4 4.015E-2
3.377E-1
1.000E0
 6 218
39 int:LRP1 LRP1 interactions 6.365E-4 4.015E-2
3.377E-1
1.000E0
 4 82
40 int:TRAP1 TRAP1 interactions 6.365E-4 4.015E-2
3.377E-1
1.000E0
 4 82
41 int:TYK2 TYK2 interactions 6.663E-4 4.100E-2
3.449E-1
1.000E0
 4 83
42 int:PPARG PPARG interactions 7.783E-4 4.355E-2
3.663E-1
1.000E0
 5 151
43 int:MMP7 MMP7 interactions 7.852E-4 4.355E-2
3.663E-1
1.000E0
 3 38
44 int:HACL1 HACL1 interactions 7.941E-4 4.355E-2
3.663E-1
1.000E0
 2 9
45 int:AVL9 AVL9 interactions 7.941E-4 4.355E-2
3.663E-1
1.000E0
 2 9
46 int:PTGS1 PTGS1 interactions 7.941E-4 4.355E-2
3.663E-1
1.000E0
 2 9
47 int:AKT1 AKT1 interactions 8.852E-4 4.752E-2
3.996E-1
1.000E0
 7 323
48 int:FABP5 FABP5 interactions 9.133E-4 4.800E-2
4.037E-1
1.000E0
 3 40
49 int:PTK2B PTK2B interactions 9.416E-4 4.801E-2
4.038E-1
1.000E0
 4 91
50 int:AK4 AK4 interactions 9.895E-4 4.801E-2
4.038E-1
1.000E0
 2 10
Show 45 more annotations

10: Cytoband [Display Chart] 73 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 8p21 8p21 9.252E-4 3.286E-2
1.602E-1
6.754E-2
 2 20
2 7q31.1 7q31.1 1.227E-3 3.286E-2
1.602E-1
8.954E-2
 2 23
3 4q22.1 4q22.1 1.692E-3 3.286E-2
1.602E-1
1.235E-1
 2 27
4 12q22-q23.1 12q22-q23.1 2.250E-3 3.286E-2
1.602E-1
1.643E-1
 1 1
5 11q22.3-q23.1 11q22.3-q23.1 2.250E-3 3.286E-2
1.602E-1
1.643E-1
 1 1
6 3p25.1 3p25.1 3.164E-3 3.771E-2
1.838E-1
2.310E-1
 2 37
7 14q24.2-q24.3 14q24.2-q24.3 4.496E-3 3.771E-2
1.838E-1
3.282E-1
 1 2
8 1p32.3-p31.3 1p32.3-p31.3 4.496E-3 3.771E-2
1.838E-1
3.282E-1
 1 2
9 11q22.3 11q22.3 4.649E-3 3.771E-2
1.838E-1
3.393E-1
 2 45
10 7p12 7p12 6.736E-3 4.470E-2
2.179E-1
4.917E-1
 1 3
11 12q21.3 12q21.3 6.736E-3 4.470E-2
2.179E-1
4.917E-1
 1 3
Show 6 more annotations

11: Transcription Factor Binding Site [Display Chart] 422 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 52 annotations before applied cutoff / 18194 genes in category

No results to display

13: Coexpression [Display Chart] 5161 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M6189 Genes down-regulated in MCF7 cells (breast cancer) after knockdown of both HIF1A and HIF2A [GeneID=3091;2034] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.595E-20 1.339E-16 1.222E-15 1.339E-16 15 104
2 M5891 Genes up-regulated in response to low oxygen levels (hypoxia). MSigDB H: Hallmark Gene Sets (v5.1) 6.746E-19 1.471E-15 1.342E-14 3.481E-15 17 200
3 M9197 Genes up-regulated in MCF7 cells (breast cancer) treated with hypoxia mimetic DMOG [PubChem=3080614]. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.550E-19 1.471E-15 1.342E-14 4.413E-15 15 130
4 M7363 Genes up-regulated in MCF7 cells (breast cancer) under hypoxia conditions. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.674E-18 2.159E-15 1.971E-14 8.638E-15 16 171
5 M2513 Genes down-regulated in MCF7 cells (breast cancer) after knockdown of HIF1A [GeneID=3091] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.156E-17 1.194E-14 1.089E-13 5.968E-14 13 91
6 M11033 Hypoxia response genes up-regulated in both astrocytes and HeLa cell line. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.536E-15 1.321E-12 1.206E-11 7.926E-12 12 98
7 M2344 Genes in the hypoxia signature, based on analysis of nine neuroblastoma cell lines in hypoxia and normal oxygen conditions. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.382E-14 1.019E-11 9.300E-11 7.134E-11 6 7
8 M1496 Genes up-regulated in normal fibroblasts under hypoxia conditions. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.303E-14 1.451E-11 1.324E-10 1.189E-10 8 25
9 M1784 Genes changed in U373-MG cells (malignant glioma) upon treatment with arsenic trioxide [PubChem=14888], a chemical that can cause autophagic cell death. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.530E-14 1.451E-11 1.324E-10 1.306E-10 12 123
10 M2345 Genes in the hypoxia signature, based on analysis of 11 neuroblastoma cell lines in hypoxia and normal oxygen conditions. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.195E-13 1.133E-10 1.034E-9 1.133E-9 8 32
11 M10508 Genes known to be induced by hypoxia MSigDB C2: CGP Curated Gene Sets (v5.1) 3.657E-13 1.716E-10 1.566E-9 1.887E-9 10 81
12 M12299 Genes that are transcriptionally regulated by HIF1A [GeneID=3091]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.240E-13 2.684E-10 2.449E-9 3.221E-9 8 36
13 M1317 Genes up-regulated in SEND cells (skin endothelium) at hypoxia after knockdown of ELK3 [GeneID=2004] and HIF1A [GeneID=3091] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.180E-12 1.660E-9 1.515E-8 2.157E-8 11 142
14 M15491 Genes down-regulated in MDA-MB-231 cells (breast cancer) after knockdown of SATB1 [GeneID=6304] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.893E-12 1.804E-9 1.646E-8 2.525E-8 16 442
15 M3996 Genes up-regulated in RPTEC cells (normal kidney) by hypoxia. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.433E-12 2.213E-9 2.020E-8 3.320E-8 14 310
16 M5333 Genes down-regulated in comparison of control polymorphonuclear leukocytes (PMN) at 6 h versus PMN treated with F. tularensis vaccine at 6 h. MSigDB C7: Immunologic Signatures (v5.1) 8.109E-12 2.547E-9 2.324E-8 4.185E-8 12 199
17 M1309 Genes down-regulated in SEND cells (skin endothelium) at hypoxia after knockdown of HIF1A [GeneID=3091] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.390E-12 2.547E-9 2.324E-8 4.330E-8 10 110
18 M14072 Genes regulated by hypoxia, based on literature searches. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.963E-11 2.283E-8 2.084E-7 4.110E-7 12 242
19 M19622 Genes up-regulated in HK-2 cells kidney tubular epithelium) under hypoxia and down-regulated on re-oxygenation. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.750E-10 1.019E-7 9.297E-7 1.936E-6 7 47
20 GSE21360 SECONDARY VS QUATERNARY MEMORY CD8 TCELL DN Genes down-regulated in memory CD8 T cells: 2' versus 4'. MSigDB C7: Immunologic Signatures (v5.1) 3.971E-10 1.025E-7 9.352E-7 2.050E-6 10 162
21 M15981 Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.850E-10 1.192E-7 1.088E-6 2.503E-6 14 430
22 M14507 Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.798E-10 2.298E-7 2.098E-6 5.057E-6 14 454
23 M5330 Genes down-regulated in comparison of control polymorphonuclear leukocytes (PMN) at 3 h versus PMN treated with F. tularensis vaccine at 3 h. MSigDB C7: Immunologic Signatures (v5.1) 2.540E-9 5.700E-7 5.202E-6 1.311E-5 10 196
24 M5890 Genes regulated by NF-kB in response to TNF [GeneID=7124]. MSigDB H: Hallmark Gene Sets (v5.1) 3.087E-9 6.373E-7 5.817E-6 1.593E-5 10 200
25 M6436 Genes down-regulated in NKT cells versus B2 B lymphocytes. MSigDB C7: Immunologic Signatures (v5.1) 3.087E-9 6.373E-7 5.817E-6 1.593E-5 10 200
26 M1304 Genes down-regulated in SEND cells (skin endothelium) at hypoxia with ELK3 [GeneID=2004] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.713E-9 1.134E-6 1.035E-5 2.949E-5 9 156
27 M16111 Genes involved in glycolysis; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.122E-8 2.145E-6 1.957E-5 5.791E-5 5 21
28 M12338 Genes changed in NIH 3T3 cells (embryonic fibroblast) by expression of one or more of C/EBP proteins: CEBPA, CEBPB, CEBPG, and CEBPD [GeneID=1050;1051;1054;1052]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.989E-8 3.666E-6 3.346E-5 1.027E-4 8 126
29 M4151 Genes up-regulated in primary fibroblast cells by expression of p50 (NFKB1) and p65 (RELA) [GeneID=4790;5970] components of NFKB. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.424E-8 4.314E-6 3.937E-5 1.251E-4 7 84
30 M1307 Genes down-regulated in SEND cells (skin endothelium) at normal oxygen (normoxia) conditions after knockdown of HIF1A [GeneID=3091] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.896E-8 4.983E-6 4.547E-5 1.495E-4 5 25
31 M18322 Genes up-regulated in RD-EF cells (rhabdomyosarcoma) engineered to express EWSR1-FLI1 fusion [GeneID=2130;2313] and which are also highly expressed in Ewing's famliy tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.358E-8 5.590E-6 5.102E-5 1.733E-4 7 88
32 M2634 Genes up-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] and engineered to express ligand-activatable EGFR [Gene ID=1956]. MSigDB C6: Oncogenic Signatures (v5.1) 3.643E-8 5.876E-6 5.363E-5 1.880E-4 9 193
33 M2698 Genes up-regulated in NCI-60 panel of cell lines with mutated TP53 [Gene ID=7157]. MSigDB C6: Oncogenic Signatures (v5.1) 3.810E-8 5.958E-6 5.437E-5 1.966E-4 9 194
34 M5353 Genes down-regulated in comparison of control polymorphonuclear leukocytes (PMN) at 0 h versus PMN treated with F. tularensis vaccine at 48 h. MSigDB C7: Immunologic Signatures (v5.1) 4.348E-8 6.566E-6 5.992E-5 2.244E-4 9 197
35 M2133 Genes up-regulated by hypoxia in TRAMP-C cells (prostatic cancer). MSigDB C2: CGP Curated Gene Sets (v5.1) 4.538E-8 6.566E-6 5.992E-5 2.342E-4 8 140
36 M5466 Genes up-regulated in head and neck tumor samples which clustered around known hypoxia genes. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.580E-8 6.566E-6 5.992E-5 2.364E-4 7 92
37 M2784 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of PCGF2 [Gene ID=7703] gene by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 4.797E-8 6.691E-6 6.107E-5 2.476E-4 8 141
38 M5937 Genes encoding proteins involved in glycolysis and gluconeogenesis. MSigDB H: Hallmark Gene Sets (v5.1) 4.952E-8 6.708E-6 6.122E-5 2.556E-4 9 200
39 M19048 Genes down-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.069E-8 6.708E-6 6.122E-5 2.616E-4 8 142
40 M2371 Genes down-regulated by VHL [GeneID=7428] and re-expressed under hypoxia conditions in renal carcinoma cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.158E-7 1.494E-5 1.363E-4 5.976E-4 4 13
41 M1570 Genes up-regulated in non-apoptotic tissues (fetal liver) after MDM4 [GeneID=4194] knockout. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.462E-7 1.800E-5 1.643E-4 7.544E-4 9 227
42 M14877 Genes down-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [GeneID=4904] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.465E-7 1.800E-5 1.643E-4 7.562E-4 11 383
43 M11581 Genes up-regulated in pilocytic astrocytoma compared to glioblastoma samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.720E-7 2.064E-5 1.884E-4 8.876E-4 5 35
44 M1098 Genes down-regulated in ME-A cells (breast cancer) undergoing apoptosis upon serum starvation (5% to 0% FCS) for 22 hr. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.891E-7 2.219E-5 2.025E-4 9.762E-4 9 234
45 M11585 Genes up-regulated in MCF7 cells (breast cancer) after stimulation with NRG1 [GeneID=3084]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.544E-7 2.918E-5 2.663E-4 1.313E-3 8 175
46 M5681 Genes up-regulated in apoptotic tissues (neuroepithelium) after MDM4 [GeneID=4194] knockout. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.657E-7 2.982E-5 2.721E-4 1.372E-3 8 176
47 M1850 Known targets of AP1 that were down-regulated by overexpression of TAM67, a dominant-negative form of JUN [GeneID=3725]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.812E-7 4.186E-5 3.820E-4 1.967E-3 4 17
48 M14515 Down-regulated genes distinguishing between M1 (pro-inflammatory) and M2 (anti-inflammatory) macrophage subtypes. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.127E-7 4.437E-5 4.050E-4 2.130E-3 6 78
49 GSE16450 CTRL VS IFNA 12H STIM IMMATURE NEURON CELL LINE DN Genes down-regulated in immature neuron cell line: control versus interferon alpha (12h). MSigDB C7: Immunologic Signatures (v5.1) 4.762E-7 5.016E-5 4.577E-4 2.458E-3 8 190
50 M17552 Genes down-regulated in RCC4 cells (renal cell carcinoma) engineered to stably express VHL [GeneID=7428] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.887E-7 5.045E-5 4.604E-4 2.522E-3 4 18
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2435 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 neurons SubClass GLRA2-hi Top 500 Cluster 4 neurons SubClass GLRA2-hi Top 500 Cluster 4 Brain Map - Barres 9.086E-10 2.213E-6 1.853E-5 2.213E-6 7 51
2 Lungmap Mouse e18.5 Epithelial (GSE52583) Top 500 All Mouse Lung E18.5 Epithelial top 500 Lungmap Mouse Single Cell (Lungmap.net) 3.197E-9 3.892E-6 3.260E-5 7.784E-6 13 396
3 neurons Top 500 All neurons Top 500 All Brain Map - Barres 4.899E-9 3.977E-6 3.330E-5 1.193E-5 14 494
4 GSM538280 500 Myeloid Cells, DC.LC.Sk, MHCII+ CD11b+ CD45+, Skin, avg-2 Immgen.org, GSE15907 1.546E-8 9.410E-6 7.881E-5 3.764E-5 13 452
5 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 2.272E-8 1.106E-5 9.265E-5 5.531E-5 13 467
6 54Dp SubClass 54Dp 2 Top 500 All 54Dp SubClass 54Dp 2 Top 500 All Brain Map - Allen iN 4.186E-8 1.563E-5 1.309E-4 1.019E-4 13 492
7 26Dp Top 500 All 26Dp Top 500 All Brain Map - Allen iN 4.494E-8 1.563E-5 1.309E-4 1.094E-4 13 495
8 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 1000 k5 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.241E-7 3.776E-5 3.162E-4 3.021E-4 7 102
9 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 1.491E-7 4.034E-5 3.379E-4 3.631E-4 12 455
10 26Dp SubClass 26Dp 4 Top 500 All 26Dp SubClass 26Dp 4 Top 500 All Brain Map - Allen iN 3.596E-7 8.309E-5 6.959E-4 8.756E-4 12 494
11 Facebase RNAseq e8.5 Hind Brain Neural Epithelium 500 FacebaseRNAseq e8.5 Hind Brain Neural Epithelium top-relative-expression-ranked 500 FaceBase_RNAseq 3.754E-7 8.309E-5 6.959E-4 9.140E-4 12 496
12 PCBC ratio EB BM CD34+ vs EB blastocyst cfr-2X-p05 EB BM CD34+ vs EB blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 7.604E-7 1.528E-4 1.280E-3 1.852E-3 6 83
13 gudmap dev gonad e11.5 F GonMes Sma 500 dev gonad e11.5 F GonMes Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.156E-7 1.528E-4 1.280E-3 1.986E-3 11 437
14 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k4 1000 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.165E-6 1.956E-4 1.638E-3 2.836E-3 9 279
15 gudmap kidney P0 JuxtaGlom Ren1 500 kidney P0 JuxtaGlom Ren1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.236E-6 1.956E-4 1.638E-3 3.009E-3 11 456
16 PCBC ratio DE vs MESO-5 cfr-2X-p05 Endoderm Differentiated Cells vs Mesoderm Day 5-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.285E-6 1.956E-4 1.638E-3 3.130E-3 8 208
17 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma 500 dev gonad e13.5 F VascAssocMesenchStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.528E-6 2.189E-4 1.833E-3 3.721E-3 10 373
18 Facebase RNAseq e8.5 Hind Brain Neural Epithelium 500 K1 FacebaseRNAseq e8.5 Hind Brain Neural Epithelium top-relative-expression-ranked 500 k-means-cluster#1 FaceBase_RNAseq 2.314E-6 3.130E-4 2.622E-3 5.635E-3 7 157
19 gudmap kidney adult JuxtaGlom Ren1 Captopr k3 1000 kidney adult JuxtaGlom Ren1 Captopr k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.550E-6 3.232E-4 2.707E-3 6.209E-3 5 57
20 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 2.786E-6 3.232E-4 2.707E-3 6.784E-3 11 496
21 gudmap developingLowerUrinaryTract adult bladder 1000 k4 DevelopingLowerUrinaryTract adult bladder emap-29457 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.869E-6 3.232E-4 2.707E-3 6.985E-3 6 104
22 gudmap dev gonad e11.5 M GonMes Sma k3 1000 dev gonad e11.5 M GonMes Sma k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.920E-6 3.232E-4 2.707E-3 7.110E-3 9 312
23 mendel RNAseq e18.5 Urothelium Krt5CreRFP 2500 K2 mendel RNAseq e18.5 Urothelium Krt5CreRFP 2500 K2 Gudmap RNAseq 5.086E-6 5.194E-4 4.350E-3 1.239E-2 10 427
24 gudmap kidney P0 JuxtaGlom Ren1 200 kidney P0 JuxtaGlom Ren1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.119E-6 5.194E-4 4.350E-3 1.246E-2 7 177
25 BM Top 100 - ventral tegmental area BM Top 100 - ventral tegmental area Body Map 6.143E-6 5.984E-4 5.011E-3 1.496E-2 5 68
26 BM Top 100 - vestibular nuclei superior BM Top 100 - vestibular nuclei superior Body Map 6.604E-6 6.184E-4 5.180E-3 1.608E-2 5 69
27 neurons Top 500 Cluster 0 neurons Top 500 Cluster 0 Brain Map - Barres 7.381E-6 6.656E-4 5.575E-3 1.797E-2 4 33
28 BM Top 100 - hypothalamus BM Top 100 - hypothalamus Body Map 9.325E-6 7.838E-4 6.565E-3 2.271E-2 5 74
29 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 200 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 9.335E-6 7.838E-4 6.565E-3 2.273E-2 7 194
30 Lungmap Mouse e18.5 Epithelial (GSE52583) Top 500 Cluster 2 Mouse Lung E18.5 Epithelial top 500 c2 Lungmap Mouse Single Cell (Lungmap.net) 1.137E-5 9.232E-4 7.732E-3 2.770E-2 6 132
31 PCBC ratio ESC vs iPSC method-OS-NL cfr-2X-p05 Pluripotent Stem Cells-reprogram NA vs Pluripotent Stem Cells-reprogram OS-NL-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.208E-5 9.486E-4 7.945E-3 2.941E-2 5 78
32 Facebase RNAseq e8.5 Hind Brain Neural Epithelium 1000 K3 FacebaseRNAseq e8.5 Hind Brain Neural Epithelium top-relative-expression-ranked 1000 k-means-cluster#3 FaceBase_RNAseq 1.310E-5 9.966E-4 8.346E-3 3.189E-2 8 285
33 12Dp Top 500 Cluster 0 12Dp Top 500 Cluster 0 Brain Map - Allen iN 1.615E-5 1.185E-3 9.924E-3 3.933E-2 4 40
34 Facebase RNAseq e8.5 Non-Floor Plate Neural Epithelium 500 FacebaseRNAseq e8.5 Non-Floor Plate Neural Epithelium top-relative-expression-ranked 500 FaceBase_RNAseq 1.655E-5 1.185E-3 9.924E-3 4.029E-2 10 489
35 80Dp Top 500 All 80Dp Top 500 All Brain Map - Allen iN 1.714E-5 1.192E-3 9.985E-3 4.173E-2 10 491
36 neurons SubClass GLRA2-hi Top 500 All neurons SubClass GLRA2-hi Top 500 All Brain Map - Barres 1.774E-5 1.197E-3 1.003E-2 4.321E-2 10 493
37 54SK SubClass 54SK 1 Top 500 All 54SK SubClass 54SK 1 Top 500 All Brain Map - Allen iN 1.869E-5 1.197E-3 1.003E-2 4.552E-2 10 496
38 26Dn SubClass 26Dn 2 Top 500 All 26Dn SubClass 26Dn 2 Top 500 All Brain Map - Allen iN 1.935E-5 1.197E-3 1.003E-2 4.711E-2 10 498
39 26Dp Top 500 Cluster 2 26Dp Top 500 Cluster 2 Brain Map - Allen iN 1.945E-5 1.197E-3 1.003E-2 4.737E-2 5 86
40 neurons SubClass TAC1-hi Top 500 Cluster 3 neurons SubClass TAC1-hi Top 500 Cluster 3 Brain Map - Barres 1.967E-5 1.197E-3 1.003E-2 4.790E-2 4 42
41 neurons SubClass CRH-med Top 500 Cluster 3 neurons SubClass CRH-med Top 500 Cluster 3 Brain Map - Barres 2.162E-5 1.284E-3 1.076E-2
5.266E-2
 4 43
42 Lungmap Mouse e18.5 Epithelial (GSE52583) SubClass Bi-potential Top 500 All Mouse Lung E18.5 Epithelial Bi-potential top 500 Lungmap Mouse Single Cell (Lungmap.net) 2.227E-5 1.291E-3 1.081E-2
5.423E-2
 9 402
43 GSM854269 500 Myeloid Cells, DC.103-11b+24+.Lu, MHCII+ CD11c+ CD103- CD11b+ CD24+, Lung, avg-2 Immgen.org, GSE15907 2.316E-5 1.302E-3 1.090E-2
5.639E-2
 9 404
44 Lungmap Mouse e18.5 Epithelial (GSE52583) SubClass ciliated Top 500 Cluster 0 Mouse Lung E18.5 Epithelial Ciliated c0 Lungmap Mouse Single Cell (Lungmap.net) 2.352E-5 1.302E-3 1.090E-2
5.728E-2
 3 15
45 GSM605761 500 alpha beta T cells, T.4.Sp.B16, 4+ 8- TCR+ 45+, B16 Melanoma Spleen, avg-2 Immgen.org, GSE15907 3.141E-5 1.700E-3 1.424E-2
7.649E-2
 8 322
46 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 500 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.317E-5 1.741E-3 1.458E-2
8.078E-2
 9 423
47 Lungmap Mouse e18.5 Epithelial (GSE52583) Top 500 Cluster 3 Mouse Lung E18.5 Epithelial top 500 c3 Lungmap Mouse Single Cell (Lungmap.net) 3.361E-5 1.741E-3 1.458E-2
8.183E-2
 4 48
48 26Dn SubClass 26Dn 2 Top 500 Cluster 1 26Dn SubClass 26Dn 2 Top 500 Cluster 1 Brain Map - Allen iN 3.496E-5 1.774E-3 1.485E-2
8.513E-2
 3 17
49 gudmap developingLowerUrinaryTract P1 bladder J 1000 k2 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.884E-5 2.334E-3 1.955E-2
1.189E-1
 7 251
50 gudmap developingKidney e15.5 Medullary collecting duct 1000 k3 DevelopingKidney e15.5 Medullary collecting duct emap-28063 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.908E-5 2.334E-3 1.955E-2
1.195E-1
 6 171
Show 45 more annotations

15: Computational [Display Chart] 304 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 5.584E-8 1.697E-5 1.069E-4 1.697E-5 15 378
2 module 306 Genes in module 306 MSigDb: C4 - CM: Cancer Modules 9.984E-7 1.518E-4 9.554E-4 3.035E-4 5 26
3 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 3.820E-5 3.870E-3 2.437E-2 1.161E-2 11 351

16: MicroRNA [Display Chart] 1043 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-323b-5p:mirSVR highEffct hsa-miR-323b-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.883E-5 3.604E-2
2.713E-1
9.265E-2
 9 455
2 hsa-miR-382:PITA hsa-miR-382:PITA TOP PITA 1.247E-4 3.604E-2
2.713E-1
1.300E-1
 7 276
3 hsa-miR-7:miRecords TarBase hsa-miR-7:miRecords TarBase miRecords_TarBase 1.592E-4 3.604E-2
2.713E-1
1.661E-1
 2 5
4 CAGTGTT,MIR-200A:MSigDB CAGTGTT,MIR-200A:MSigDB MSigDB 1.728E-4 3.604E-2
2.713E-1
1.802E-1
 7 291
5 CAGTGTT,MIR-141:MSigDB CAGTGTT,MIR-141:MSigDB MSigDB 1.728E-4 3.604E-2
2.713E-1
1.802E-1
 7 291

17: Drug [Display Chart] 17823 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C016837 zinc chloride CTD 3.056E-13 5.447E-9 5.646E-8 5.447E-9 16 372
2 1276 DN Dequalinium dichloride [522-51-0]; Down 200; 7.6uM; HL60; HT HG-U133A Broad Institute CMAP 1.467E-12 8.356E-9 8.661E-8 2.615E-8 12 174
3 5023 UP Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 1.467E-12 8.356E-9 8.661E-8 2.615E-8 12 174
4 7139 UP Chrysene-1,4-quinone [100900-16-1]; Up 200; 15.4uM; PC3; HT HG-U133A Broad Institute CMAP 2.195E-12 8.356E-9 8.661E-8 3.912E-8 12 180
5 1285 DN Ketoconazole [65277-42-1]; Down 200; 7.6uM; HL60; HT HG-U133A Broad Institute CMAP 2.344E-12 8.356E-9 8.661E-8 4.178E-8 12 181
6 573 UP deferoxamine mesylate salt; Up 200; 100uM; MCF7; HG-U133A Broad Institute CMAP 2.849E-12 8.462E-9 8.771E-8 5.077E-8 12 184
7 C025205 1,10-phenanthroline CTD 1.266E-11 3.224E-8 3.342E-7 2.257E-7 9 80
8 904 UP 5109870; Up 200; 25uM; MCF7; HT HG-U133A EA Broad Institute CMAP 2.062E-11 4.359E-8 4.518E-7 3.675E-7 11 166
9 6677 UP Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; PC3; HT HG-U133A Broad Institute CMAP 2.201E-11 4.359E-8 4.518E-7 3.923E-7 11 167
10 C026305 cobalt sulfate CTD 3.862E-11 6.883E-8 7.135E-7 6.883E-7 7 35
11 D017258 Medroxyprogesterone Acetate CTD 1.183E-10 1.917E-7 1.987E-6 2.109E-6 14 390
12 1791 UP Azaguanine-8 [134-58-7]; Up 200; 26.2uM; PC3; HT HG-U133A Broad Institute CMAP 2.809E-10 4.172E-7 4.325E-6 5.007E-6 10 158
13 4444 UP SAHA; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 4.300E-10 5.896E-7 6.111E-6 7.664E-6 10 165
14 3317 UP Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 4.839E-10 6.161E-7 6.386E-6 8.625E-6 10 167
15 C025340 manganese chloride CTD 8.888E-10 1.056E-6 1.095E-5 1.584E-5 13 375
16 C452423 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine CTD 1.030E-9 1.148E-6 1.190E-5 1.837E-5 6 30
17 D003676 Deferoxamine CTD 1.182E-9 1.239E-6 1.285E-5 2.107E-5 10 183
18 CID000002214 apocynin Stitch 1.384E-9 1.371E-6 1.421E-5 2.468E-5 10 186
19 460 UP deferoxamine mesylate salt; Up 200; 100uM; PC3; HG-U133A Broad Institute CMAP 1.702E-9 1.597E-6 1.655E-5 3.033E-5 10 190
20 D010656 Phenylephrine CTD 2.960E-9 2.638E-6 2.735E-5 5.276E-5 14 500
21 D003513 Cycloheximide CTD 5.610E-9 4.762E-6 4.936E-5 9.999E-5 13 437
22 D008345 Manganese CTD 6.255E-9 5.067E-6 5.252E-5 1.115E-4 13 441
23 D016566 Organoselenium Compounds CTD 6.882E-9 5.333E-6 5.528E-5 1.227E-4 7 71
24 MESH:D011471/C105934-T Prostatic Neoplasms affected by celecoxib CTD Therapeutic 8.138E-9 6.044E-6 6.265E-5 1.451E-4 5 20
25 4454 UP thioridazine hydrochloride; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 9.994E-9 6.949E-6 7.203E-5 1.781E-4 9 168
26 CID003015678 CoCl2 Stitch 1.015E-8 6.949E-6 7.203E-5 1.810E-4 7 75
27 C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one CTD 1.053E-8 6.949E-6 7.203E-5 1.876E-4 12 376
28 7077 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 1.291E-8 7.933E-6 8.223E-5 2.300E-4 9 173
29 7285 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.291E-8 7.933E-6 8.223E-5 2.300E-4 9 173
30 4652 UP Phenoxybenzamine hydrochloride [63-92-3]; Up 200; 11.8uM; PC3; HT HG-U133A Broad Institute CMAP 1.823E-8 1.018E-5 1.055E-4 3.248E-4 9 180
31 MESH:D001943/D001564-M Breast Neoplasms affected by Benzo(a)pyrene CTD Marker 1.835E-8 1.018E-5 1.055E-4 3.271E-4 8 126
32 D002118 Calcium CTD 1.839E-8 1.018E-5 1.055E-4 3.277E-4 13 483
33 D002211 Capsaicin CTD 1.884E-8 1.018E-5 1.055E-4 3.358E-4 13 484
34 D007069 Ifosfamide CTD 1.949E-8 1.021E-5 1.059E-4 3.473E-4 10 245
35 C011512 alpha-naphthoflavone CTD 2.208E-8 1.124E-5 1.165E-4 3.935E-4 8 129
36 4163 UP Trimipramine maleate salt [521-78-8]; Up 200; 9.8uM; MCF7; HT HG-U133A Broad Institute CMAP 2.537E-8 1.256E-5 1.302E-4 4.522E-4 9 187
37 3448 UP Dienestrol [84-17-3]; Up 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 3.047E-8 1.468E-5 1.521E-4 5.430E-4 9 191
38 7248 UP Triprolidine hydrochloride [550-70-9]; Up 200; 12.8uM; PC3; HT HG-U133A Broad Institute CMAP 3.187E-8 1.495E-5 1.550E-4 5.681E-4 9 192
39 C002791 bismuth tripotassium dicitrate CTD 3.341E-8 1.527E-5 1.582E-4 5.954E-4 8 136
40 1627 UP Cefoperazone dihydrate; Up 200; 5.8uM; HL60; HG-U133A Broad Institute CMAP 3.644E-8 1.616E-5 1.675E-4 6.494E-4 9 195
41 C113580 U 0126 CTD 3.758E-8 1.616E-5 1.675E-4 6.697E-4 12 422
42 D003345 Corticosterone CTD 3.807E-8 1.616E-5 1.675E-4 6.785E-4 10 263
43 C022884 undecane CTD 4.340E-8 1.799E-5 1.865E-4 7.735E-4 9 199
44 D019311 Staurosporine CTD 4.942E-8 2.002E-5 2.075E-4 8.808E-4 8 143
45 D003035 Cobalt CTD 5.989E-8 2.372E-5 2.459E-4 1.067E-3 10 276
46 C459604 candoxin CTD 8.160E-8 3.162E-5 3.277E-4 1.454E-3 7 101
47 C002802 tungsten carbide CTD 9.238E-8 3.503E-5 3.631E-4 1.646E-3 8 155
48 C432165 anthra(1,9-cd)pyrazol-6(2H)-one CTD 9.508E-8 3.531E-5 3.660E-4 1.695E-3 10 290
49 D007052 Ibuprofen CTD 1.080E-7 3.929E-5 4.073E-4 1.925E-3 10 294
50 CID000014888 arsenic trioxide Stitch 1.157E-7 4.126E-5 4.276E-4 2.063E-3 12 468
Show 45 more annotations

18: Disease [Display Chart] 2138 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0220641 Lip and Oral Cavity Carcinoma DisGeNET BeFree 4.660E-10 9.962E-7 8.214E-6 9.962E-7 15 419
2 umls:C0153381 Malignant neoplasm of mouth DisGeNET BeFree 3.504E-9 2.825E-6 2.329E-5 7.492E-6 14 410
3 umls:C0038356 Stomach Neoplasms DisGeNET Curated 3.964E-9 2.825E-6 2.329E-5 8.474E-6 15 490
4 umls:C0018799 Heart Diseases DisGeNET Curated 4.301E-8 2.299E-5 1.895E-4 9.195E-5 11 277
5 umls:C0007193 Cardiomyopathy, Dilated DisGeNET Curated 8.130E-8 3.476E-5 2.866E-4 1.738E-4 12 366
6 umls:C0334579 Anaplastic astrocytoma DisGeNET Curated 1.846E-7 6.577E-5 5.423E-4 3.946E-4 8 137
7 umls:C0206734 Hemangioblastoma DisGeNET Curated 4.125E-7 1.260E-4 1.039E-3 8.820E-4 5 34
8 umls:C1621958 Glioblastoma Multiforme DisGeNET BeFree 5.083E-7 1.358E-4 1.120E-3 1.087E-3 12 434
9 umls:C0948089 Acute Coronary Syndrome DisGeNET Curated 1.164E-6 2.764E-4 2.279E-3 2.488E-3 9 237
10 umls:C0016057 Fibrosarcoma DisGeNET Curated 1.337E-6 2.770E-4 2.284E-3 2.858E-3 9 241
11 umls:C0034069 Pulmonary Fibrosis DisGeNET Curated 1.532E-6 2.770E-4 2.284E-3 3.276E-3 10 317
12 umls:C0007787 Transient Ischemic Attack DisGeNET Curated 1.555E-6 2.770E-4 2.284E-3 3.324E-3 5 44
13 umls:C0374997 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site DisGeNET BeFree 1.764E-6 2.901E-4 2.392E-3 3.771E-3 10 322
14 umls:C0027626 Neoplasm Invasiveness DisGeNET Curated 2.161E-6 3.092E-4 2.549E-3 4.620E-3 7 132
15 umls:C0008031 Chest Pain DisGeNET Curated 2.169E-6 3.092E-4 2.549E-3 4.638E-3 4 21
16 umls:C0041948 Uremia DisGeNET Curated 2.417E-6 3.230E-4 2.663E-3 5.167E-3 5 48
17 umls:C0149521 Pancreatitis, Chronic DisGeNET Curated 3.510E-6 4.414E-4 3.639E-3 7.503E-3 9 271
18 umls:C0014556 Epilepsy, Temporal Lobe DisGeNET Curated 4.627E-6 5.304E-4 4.374E-3 9.892E-3 7 148
19 umls:C0007124 Noninfiltrating Intraductal Carcinoma DisGeNET Curated 4.714E-6 5.304E-4 4.374E-3 1.008E-2 9 281
20 umls:C1334274 Invasive Carcinoma DisGeNET BeFree 6.015E-6 5.805E-4 4.786E-3 1.286E-2 7 154
21 umls:C0032580 Adenomatous Polyposis Coli DisGeNET Curated 6.217E-6 5.805E-4 4.786E-3 1.329E-2 10 371
22 umls:C1708565 Invasive Skin Melanoma DisGeNET BeFree 6.231E-6 5.805E-4 4.786E-3 1.332E-2 4 27
23 umls:C0027859 Acoustic Neuroma DisGeNET Curated 6.245E-6 5.805E-4 4.786E-3 1.335E-2 5 58
24 umls:C1266042 Chromophobe Renal Cell Carcinoma DisGeNET Curated 9.631E-6 8.580E-4 7.074E-3 2.059E-2 4 30
25 umls:C0281361 Adenocarcinoma of pancreas DisGeNET BeFree 1.014E-5 8.673E-4 7.151E-3 2.168E-2 9 309
26 umls:C0020456 Hyperglycemia DisGeNET Curated 1.200E-5 9.402E-4 7.752E-3 2.566E-2 10 400
27 umls:C0812413 Malignant Pleural Mesothelioma DisGeNET BeFree 1.238E-5 9.402E-4 7.752E-3 2.647E-2 8 240
28 umls:C0338106 Adenocarcinoma of colon DisGeNET Curated 1.238E-5 9.402E-4 7.752E-3 2.647E-2 8 240
29 umls:C0011303 Demyelinating Diseases DisGeNET Curated 1.275E-5 9.402E-4 7.752E-3 2.727E-2 5 67
30 umls:C0041696 Unipolar Depression DisGeNET BeFree 1.336E-5 9.524E-4 7.853E-3 2.857E-2 10 405
31 umls:C0023269 leiomyosarcoma DisGeNET Curated 1.457E-5 9.986E-4 8.233E-3 3.114E-2 6 117
32 umls:C0013537 Eclampsia DisGeNET BeFree 1.495E-5 9.986E-4 8.233E-3 3.195E-2 7 177
33 umls:C0278883 Metastatic melanoma DisGeNET BeFree 1.840E-5 1.164E-3 9.597E-3 3.933E-2 9 333
34 umls:C0004045 Asphyxia Neonatorum DisGeNET Curated 1.893E-5 1.164E-3 9.597E-3 4.047E-2 3 12
35 umls:C0021051 Immunologic Deficiency Syndromes DisGeNET Curated 1.905E-5 1.164E-3 9.597E-3 4.074E-2 10 422
36 umls:C0020312 Hydrothorax DisGeNET BeFree 2.015E-5 1.197E-3 9.868E-3 4.309E-2 2 2
37 umls:C0520459 Necrotizing Enterocolitis DisGeNET Curated 2.076E-5 1.199E-3 9.889E-3 4.438E-2 5 74
38 umls:C0278488 Carcinoma breast stage IV DisGeNET BeFree 2.219E-5 1.249E-3 1.029E-2 4.744E-2 9 341
39 umls:C0684337 Ewings sarcoma-primitive neuroectodermal tumor (PNET) DisGeNET Curated 2.364E-5 1.296E-3 1.068E-2
5.054E-2
 5 76
40 umls:C0042373 Vascular Diseases DisGeNET Curated 2.489E-5 1.314E-3 1.084E-2
5.321E-2
 9 346
41 umls:C1269683 Major Depressive Disorder DisGeNET Curated 2.520E-5 1.314E-3 1.084E-2
5.388E-2
 10 436
42 umls:C1519670 Tumor Angiogenesis DisGeNET BeFree 2.887E-5 1.438E-3 1.185E-2
6.172E-2
 10 443
43 umls:C0878500 Intraepithelial Neoplasia DisGeNET BeFree 2.891E-5 1.438E-3 1.185E-2
6.181E-2
 6 132
44 umls:C0220650 Metastatic malignant neoplasm to brain DisGeNET BeFree 3.017E-5 1.466E-3 1.209E-2
6.450E-2
 6 133
45 umls:C0280324 Laryngeal Squamous Cell Carcinoma DisGeNET Curated 3.147E-5 1.495E-3 1.233E-2
6.729E-2
 6 134
46 umls:C0403416 Idiopathic crescentic glomerulonephritis DisGeNET BeFree 3.428E-5 1.593E-3 1.314E-2
7.329E-2
 4 41
47 umls:C0750979 Primary malignant neoplasm of brain DisGeNET BeFree 3.776E-5 1.718E-3 1.416E-2
8.073E-2
 4 42
48 umls:C1561643 Chronic Kidney Diseases DisGeNET Curated 4.139E-5 1.810E-3 1.493E-2
8.850E-2
 8 284
49 umls:C0042345 Varicosity DisGeNET Curated 4.149E-5 1.810E-3 1.493E-2
8.870E-2
 4 43
50 umls:C0023267 Fibroid Tumor DisGeNET Curated 4.459E-5 1.869E-3 1.541E-2
9.533E-2
 8 287
Show 45 more annotations