Toppgene analysis for aggregated_1964_log, IC25, positive side

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1: GO: Molecular Function [Display Chart] 577 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0009922 fatty acid elongase activity 9.129E-6 5.267E-3 3.653E-2 5.267E-3 3 7
2 GO:0004312 fatty acid synthase activity 4.223E-5 1.218E-2
8.450E-2
2.436E-2 3 11
3 GO:0048037 cofactor binding 8.374E-5 1.611E-2
1.117E-1
4.832E-2 9 278
4 GO:0051015 actin filament binding 2.396E-4 2.366E-2
1.641E-1
1.382E-1
6 134
5 GO:0004720 protein-lysine 6-oxidase activity 2.480E-4 2.366E-2
1.641E-1
1.431E-1
2 4
6 GO:0050662 coenzyme binding 2.654E-4 2.366E-2
1.641E-1
1.531E-1
7 193
7 GO:0031625 ubiquitin protein ligase binding 4.096E-4 2.366E-2
1.641E-1
2.363E-1
8 273
8 GO:0008823 cupric reductase activity 4.116E-4 2.366E-2
1.641E-1
2.375E-1
2 5
9 GO:0052851 ferric-chelate reductase (NADPH) activity 4.116E-4 2.366E-2
1.641E-1
2.375E-1
2 5
10 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 4.116E-4 2.366E-2
1.641E-1
2.375E-1
2 5
11 GO:0044389 ubiquitin-like protein ligase binding 4.511E-4 2.366E-2
1.641E-1
2.603E-1
8 277
12 GO:0016215 acyl-CoA desaturase activity 8.569E-4 4.120E-2
2.858E-1
4.945E-1
2 7
13 GO:0043177 organic acid binding 1.045E-3 4.636E-2
3.216E-1
6.027E-1
7 243
14 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1.138E-3 4.689E-2
3.252E-1
6.565E-1
2 8
Show 9 more annotations

2: GO: Biological Process [Display Chart] 2497 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016126 sterol biosynthetic process 3.164E-17 7.901E-14 6.637E-13 7.901E-14 13 56
2 GO:1902653 secondary alcohol biosynthetic process 4.592E-16 3.822E-13 3.211E-12 1.147E-12 12 51
3 GO:0006695 cholesterol biosynthetic process 4.592E-16 3.822E-13 3.211E-12 1.147E-12 12 51
4 GO:0016125 sterol metabolic process 4.606E-14 2.875E-11 2.415E-10 1.150E-10 15 148
5 GO:0008202 steroid metabolic process 2.279E-13 1.138E-10 9.562E-10 5.691E-10 19 316
6 GO:0046165 alcohol biosynthetic process 2.579E-12 1.073E-9 9.016E-9 6.440E-9 14 160
7 GO:0008203 cholesterol metabolic process 4.757E-12 1.697E-9 1.425E-8 1.188E-8 13 135
8 GO:1902652 secondary alcohol metabolic process 7.592E-12 2.370E-9 1.990E-8 1.896E-8 13 140
9 GO:0006694 steroid biosynthetic process 1.033E-10 2.866E-8 2.408E-7 2.579E-7 13 172
10 GO:0006066 alcohol metabolic process 1.954E-10 4.879E-8 4.098E-7 4.879E-7 18 411
11 GO:1901617 organic hydroxy compound biosynthetic process 6.617E-10 1.502E-7 1.262E-6 1.652E-6 14 242
12 GO:0033489 cholesterol biosynthetic process via desmosterol 1.091E-6 2.095E-4 1.760E-3 2.723E-3 3 4
13 GO:0033490 cholesterol biosynthetic process via lathosterol 1.091E-6 2.095E-4 1.760E-3 2.723E-3 3 4
14 GO:0036109 alpha-linolenic acid metabolic process 1.196E-6 2.132E-4 1.791E-3 2.985E-3 4 13
15 GO:0006633 fatty acid biosynthetic process 5.326E-6 8.866E-4 7.447E-3 1.330E-2 8 146
16 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process 6.882E-6 1.074E-3 9.023E-3 1.719E-2 5 41
17 GO:0046949 fatty-acyl-CoA biosynthetic process 8.748E-6 1.285E-3 1.079E-2 2.184E-2 5 43
18 GO:0035336 long-chain fatty-acyl-CoA metabolic process 1.099E-5 1.524E-3 1.280E-2 2.744E-2 5 45
19 GO:0006732 coenzyme metabolic process 1.319E-5 1.733E-3 1.456E-2 3.293E-2 11 336
20 GO:0035337 fatty-acyl-CoA metabolic process 2.254E-5 2.814E-3 2.363E-2
5.627E-2
5 52
21 GO:0008299 isoprenoid biosynthetic process 3.662E-5 4.355E-3 3.658E-2
9.145E-2
4 29
22 GO:0006631 fatty acid metabolic process 4.089E-5 4.469E-3 3.754E-2
1.021E-1
11 380
23 GO:0046394 carboxylic acid biosynthetic process 4.295E-5 4.469E-3 3.754E-2
1.072E-1
10 315
24 GO:0016053 organic acid biosynthetic process 4.295E-5 4.469E-3 3.754E-2
1.072E-1
10 315
25 GO:0071616 acyl-CoA biosynthetic process 5.326E-5 5.115E-3 4.296E-2
1.330E-1
5 62
26 GO:0035384 thioester biosynthetic process 5.326E-5 5.115E-3 4.296E-2
1.330E-1
5 62
27 GO:0030497 fatty acid elongation 7.468E-5 6.907E-3
5.802E-2
1.865E-1
3 13
28 GO:0051186 cofactor metabolic process 8.443E-5 7.415E-3
6.229E-2
2.108E-1
11 412
29 GO:0031668 cellular response to extracellular stimulus 8.625E-5 7.415E-3
6.229E-2
2.154E-1
8 215
30 GO:0072330 monocarboxylic acid biosynthetic process 8.909E-5 7.415E-3
6.229E-2
2.225E-1
8 216
31 GO:0097286 iron ion import 9.460E-5 7.620E-3
6.401E-2
2.362E-1
3 14
32 GO:0034625 fatty acid elongation, monounsaturated fatty acid 1.270E-4 9.789E-3
8.223E-2
3.172E-1
2 3
33 GO:0015682 ferric iron transport 1.333E-4 9.789E-3
8.223E-2
3.328E-1
4 40
34 GO:0072512 trivalent inorganic cation transport 1.333E-4 9.789E-3
8.223E-2
3.328E-1
4 40
35 GO:0043651 linoleic acid metabolic process 1.441E-4 1.028E-2
8.639E-2
3.599E-1
3 16
36 GO:0031669 cellular response to nutrient levels 1.905E-4 1.322E-2
1.110E-1
4.758E-1
7 181
37 GO:0009267 cellular response to starvation 2.057E-4 1.388E-2
1.166E-1
5.137E-1
6 129
38 GO:0019322 pentose biosynthetic process 2.530E-4 1.662E-2
1.396E-1
6.317E-1
2 4
39 GO:0061041 regulation of wound healing 2.739E-4 1.754E-2
1.473E-1
6.839E-1
6 136
40 GO:0009108 coenzyme biosynthetic process 2.963E-4 1.807E-2
1.518E-1
7.398E-1
6 138
41 GO:0001676 long-chain fatty acid metabolic process 2.968E-4 1.807E-2
1.518E-1
7.411E-1
5 89
42 GO:0042493 response to drug 3.238E-4 1.925E-2
1.617E-1
8.084E-1
11 481
43 GO:0055129 L-proline biosynthetic process 4.198E-4 2.230E-2
1.874E-1
1.000E0
2 5
44 GO:0019368 fatty acid elongation, unsaturated fatty acid 4.198E-4 2.230E-2
1.874E-1
1.000E0
2 5
45 GO:0019367 fatty acid elongation, saturated fatty acid 4.198E-4 2.230E-2
1.874E-1
1.000E0
2 5
46 GO:0097461 ferric iron import into cell 4.198E-4 2.230E-2
1.874E-1
1.000E0
2 5
47 GO:0033216 ferric iron import 4.198E-4 2.230E-2
1.874E-1
1.000E0
2 5
48 GO:0006637 acyl-CoA metabolic process 4.855E-4 2.474E-2
2.078E-1
1.000E0
5 99
49 GO:0035383 thioester metabolic process 4.855E-4 2.474E-2
2.078E-1
1.000E0
5 99
50 GO:0044272 sulfur compound biosynthetic process 6.186E-4 3.081E-2
2.588E-1
1.000E0
7 220
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 258 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030176 integral component of endoplasmic reticulum membrane 2.912E-4 4.553E-2
2.792E-1
7.513E-2
6 137
2 GO:0031227 intrinsic component of endoplasmic reticulum membrane 3.530E-4 4.553E-2
2.792E-1
9.107E-2
6 142

4: Human Phenotype [Display Chart] 453 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0003465 Elevated 8(9)-cholestenol 4.783E-5 1.083E-2
7.252E-2
2.167E-2 2 2
2 HP:0003462 Elevated 8-dehydrocholesterol 4.783E-5 1.083E-2
7.252E-2
2.167E-2 2 2
3 HP:0001776 Bilateral talipes equinovarus 1.429E-4 2.157E-2
1.444E-1
6.472E-2
2 3
4 HP:0006685 Endocardial fibrosis 2.845E-4 3.222E-2
2.157E-1
1.289E-1
2 4

5: Mouse Phenotype [Display Chart] 2259 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002139 abnormal hepatobiliary system physiology 2.596E-5 3.954E-2
3.282E-1
5.863E-2
14 434
2 MP:0002625 heart left ventricle hypertrophy 3.501E-5 3.954E-2
3.282E-1
7.909E-2
6 70
3 MP:0010579 increased heart left ventricle size 5.951E-5 4.089E-2
3.394E-1
1.344E-1
7 112
4 MP:0009888 palatal shelves fail to meet at midline 8.539E-5 4.089E-2
3.394E-1
1.929E-1
5 51
5 MP:0003717 pallor 1.070E-4 4.089E-2
3.394E-1
2.417E-1
9 212
6 MP:0012776 abnormal liver cholesterol level 1.126E-4 4.089E-2
3.394E-1
2.543E-1
5 54
7 MP:0010578 abnormal heart left ventricle size 1.385E-4 4.089E-2
3.394E-1
3.128E-1
7 128
8 MP:0008944 decreased sensitivity to induced cell death 1.629E-4 4.089E-2
3.394E-1
3.680E-1
6 92
9 MP:0010901 abnormal pulmonary alveolar parenchyma morphology 1.629E-4 4.089E-2
3.394E-1
3.680E-1
6 92
10 MP:0000609 abnormal liver physiology 2.018E-4 4.559E-2
3.784E-1
4.559E-1
12 399
11 MP:0000010 abnormal abdominal fat pad morphology 2.405E-4 4.765E-2
3.955E-1
5.432E-1
9 236
12 MP:0001178 pulmonary hypoplasia 2.531E-4 4.765E-2
3.955E-1
5.719E-1
5 64
Show 7 more annotations

6: Domain [Display Chart] 1028 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS01188 ELO PROSITE 1.019E-5 3.493E-3 2.624E-2 1.048E-2 3 7
2 PF01151 ELO Pfam 1.019E-5 3.493E-3 2.624E-2 1.048E-2 3 7
3 IPR002076 ELO fam InterPro 1.019E-5 3.493E-3 2.624E-2 1.048E-2 3 7

7: Pathway [Display Chart] 753 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SMP00023 Steroid Biosynthesis SMPDB 3.474E-18 2.616E-15 1.884E-14 2.616E-15 11 21
2 PW:0000454 cholesterol biosynthetic Pathway Ontology 5.673E-17 1.844E-14 1.328E-13 4.272E-14 10 18
3 142269 superpathway of cholesterol biosynthesis BioSystems: BIOCYC 7.347E-17 1.844E-14 1.328E-13 5.532E-14 11 26
4 106142 Cholesterol biosynthesis BioSystems: REACTOME 8.151E-16 1.534E-13 1.105E-12 6.137E-13 10 22
5 198809 Cholesterol biosynthesis BioSystems: WikiPathways 5.093E-13 7.670E-11 5.524E-10 3.835E-10 8 17
6 82937 Steroid biosynthesis BioSystems: KEGG 2.584E-12 3.243E-10 2.336E-9 1.946E-9 8 20
7 142268 cholesterol biosynthesis III (via desmosterol) BioSystems: BIOCYC 4.605E-12 3.853E-10 2.775E-9 3.467E-9 7 13
8 142266 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) BioSystems: BIOCYC 4.605E-12 3.853E-10 2.775E-9 3.467E-9 7 13
9 142267 cholesterol biosynthesis I BioSystems: BIOCYC 4.605E-12 3.853E-10 2.775E-9 3.467E-9 7 13
10 219802 SREBP signalling BioSystems: WikiPathways 3.290E-9 2.478E-7 1.784E-6 2.478E-6 9 64
11 685551 Regulation of Cholesterol Biosynthesis by SREBP (SREBF) BioSystems: REACTOME 1.442E-8 9.869E-7 7.107E-6 1.086E-5 8 53
12 413390 Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol BioSystems: KEGG 1.886E-8 1.052E-6 7.573E-6 1.420E-5 5 11
13 SMP00089 Pravastatin Pathway SMPDB 3.212E-8 1.052E-6 7.573E-6 2.419E-5 5 12
14 SMP00119 Fluvastatin Pathway SMPDB 3.212E-8 1.052E-6 7.573E-6 2.419E-5 5 12
15 SMP00092 Rosuvastatin Pathway SMPDB 3.212E-8 1.052E-6 7.573E-6 2.419E-5 5 12
16 SMP00079 Ibandronate Pathway SMPDB 3.212E-8 1.052E-6 7.573E-6 2.419E-5 5 12
17 SMP00095 Alendronate pathway SMPDB 3.212E-8 1.052E-6 7.573E-6 2.419E-5 5 12
18 SMP00099 Lovastatin Pathway SMPDB 3.212E-8 1.052E-6 7.573E-6 2.419E-5 5 12
19 SMP00112 Risedronate Pathway SMPDB 3.212E-8 1.052E-6 7.573E-6 2.419E-5 5 12
20 SMP00107 Zoledronate Pathway SMPDB 3.212E-8 1.052E-6 7.573E-6 2.419E-5 5 12
21 SMP00131 Atorvastatin Pathway SMPDB 3.212E-8 1.052E-6 7.573E-6 2.419E-5 5 12
22 SMP00111 Cerivastatin Pathway SMPDB 3.212E-8 1.052E-6 7.573E-6 2.419E-5 5 12
23 SMP00117 Pamidronate Pathway SMPDB 3.212E-8 1.052E-6 7.573E-6 2.419E-5 5 12
24 685552 Activation of Gene Expression by SREBP (SREBF) BioSystems: REACTOME 4.142E-8 1.299E-6 9.358E-6 3.119E-5 7 40
25 PW:0000248 steroid biosynthetic Pathway Ontology 6.287E-7 1.894E-5 1.364E-4 4.734E-4 4 9
26 83034 Biosynthesis of unsaturated fatty acids BioSystems: KEGG 7.762E-7 2.248E-5 1.619E-4 5.845E-4 5 21
27 413387 C5 isoprenoid biosynthesis, mevalonate pathway BioSystems: KEGG 1.041E-6 2.799E-5 2.016E-4 7.838E-4 4 10
28 MAP00100 Sterol biosynthesis MAP00100 Sterol biosynthesis GenMAPP 1.041E-6 2.799E-5 2.016E-4 7.838E-4 4 10
29 P00014 Cholesterol biosynthesis PantherDB 1.625E-6 4.078E-5 2.937E-4 1.224E-3 4 11
30 142207 mevalonate pathway I BioSystems: BIOCYC 1.625E-6 4.078E-5 2.937E-4 1.224E-3 4 11
31 PW:0000184 terpenoid biosynthetic Pathway Ontology 2.458E-6 5.972E-5 4.301E-4 1.851E-3 3 4
32 868084 Fatty acid metabolism BioSystems: KEGG 3.183E-6 7.490E-5 5.394E-4 2.397E-3 6 48
33 545288 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) BioSystems: BIOCYC 3.474E-6 7.928E-5 5.710E-4 2.616E-3 4 13
34 160977 Fatty acid, triacylglycerol, and ketone body metabolism BioSystems: REACTOME 4.667E-6 1.034E-4 7.444E-4 3.514E-3 10 188
35 755438 SREBF and miR33 in cholesterol and lipid homeostasis BioSystems: WikiPathways 1.439E-5 3.095E-4 2.229E-3 1.083E-2 4 18
36 106115 Fatty Acyl-CoA Biosynthesis BioSystems: REACTOME 2.248E-5 4.702E-4 3.386E-3 1.693E-2 4 20
37 83022 Terpenoid backbone biosynthesis BioSystems: KEGG 2.759E-5 5.614E-4 4.043E-3 2.077E-2 4 21
38 142287 epoxysqualene biosynthesis BioSystems: BIOCYC 7.337E-5 1.454E-3 1.047E-2
5.525E-2
2 2
39 413482 Fatty acid biosynthesis, elongation, endoplasmic reticulum BioSystems: KEGG 9.706E-5 1.874E-3 1.350E-2
7.309E-2
3 11
40 198852 Statin Pathway BioSystems: WikiPathways 1.542E-4 2.902E-3 2.090E-2
1.161E-1
4 32
41 645344 alpha-linolenic acid (ALA) metabolism BioSystems: REACTOME 1.661E-4 2.979E-3 2.145E-2
1.251E-1
3 13
42 645343 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism BioSystems: REACTOME 1.661E-4 2.979E-3 2.145E-2
1.251E-1
3 13
43 160978 Synthesis of very long-chain fatty acyl-CoAs BioSystems: REACTOME 3.193E-4 5.591E-3 4.027E-2
2.404E-1
3 16
44 106114 Triglyceride Biosynthesis BioSystems: REACTOME 4.493E-4 7.689E-3
5.538E-2
3.383E-1
4 42
45 530749 PPARA Activates Gene Expression BioSystems: REACTOME 5.515E-4 9.229E-3
6.647E-2
4.153E-1
6 119
46 119544 Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) BioSystems: REACTOME 6.293E-4 1.016E-2
7.315E-2
4.739E-1
6 122
47 198758 Urea cycle and metabolism of amino groups BioSystems: WikiPathways 6.339E-4 1.016E-2
7.315E-2
4.774E-1
3 20
48 82934 Fatty acid elongation BioSystems: KEGG 9.666E-4 1.516E-2
1.092E-1
7.278E-1
3 23
49 545317 zymosterol biosynthesis BioSystems: BIOCYC 1.076E-3 1.654E-2
1.191E-1
8.103E-1
2 6
50 814926 Carbon metabolism BioSystems: KEGG 1.217E-3 1.833E-2
1.320E-1
9.164E-1
5 93
Show 45 more annotations

8: Pubmed [Display Chart] 18603 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18660489 Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. Pubmed 1.097E-29 1.020E-25 1.062E-24 2.041E-25 23 250
2 18660489:gr Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. GeneRIF 1.097E-29 1.020E-25 1.062E-24 2.041E-25 23 250
3 21319273 An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. Pubmed 3.056E-10 1.895E-6 1.972E-5 5.685E-6 12 397
4 16009940 Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. Pubmed 4.245E-9 1.974E-5 2.055E-4 7.896E-5 8 152
5 16806233 Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. Pubmed 1.614E-8 6.003E-5 6.248E-4 3.002E-4 6 67
6 20602615:gr Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? GeneRIF 2.640E-8 7.015E-5 7.301E-4 4.910E-4 8 192
7 20602615 Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? Pubmed 2.640E-8 7.015E-5 7.301E-4 4.910E-4 8 192
8 17855807 Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery. Pubmed 5.913E-8 1.106E-4 1.151E-3 1.100E-3 4 16
9 17855807:gr Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery. GeneRIF 5.913E-8 1.106E-4 1.151E-3 1.100E-3 4 16
10 25852190 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Pubmed 5.943E-8 1.106E-4 1.151E-3 1.106E-3 10 401
11 23125841 Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1. Pubmed 1.519E-7 2.568E-4 2.673E-3 2.825E-3 8 241
12 21081666 Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Pubmed 2.551E-7 3.790E-4 3.945E-3 4.746E-3 8 258
13 19956635:gr Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. GeneRIF 2.852E-7 3.790E-4 3.945E-3 5.306E-3 6 108
14 19956635 Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. Pubmed 2.852E-7 3.790E-4 3.945E-3 5.306E-3 6 108
15 20603810:gr mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle. GeneRIF 4.868E-7 6.038E-4 6.284E-3 9.057E-3 3 7
16 8944226 Biosynthesis of triacylglycerols. Pubmed 6.504E-7 7.349E-4 7.649E-3 1.210E-2 4 28
17 25147182 Quantitative Lys-¿-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. Pubmed 6.716E-7 7.349E-4 7.649E-3 1.249E-2 9 401
18 20972250:gr Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. GeneRIF 7.530E-7 7.373E-4 7.674E-3 1.401E-2 4 29
19 20972250 Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. Pubmed 7.530E-7 7.373E-4 7.674E-3 1.401E-2 4 29
20 16027165 Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins. Pubmed 8.672E-7 8.002E-4 8.328E-3 1.613E-2 4 30
21 16385451 A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Pubmed 9.278E-7 8.002E-4 8.328E-3 1.726E-2 9 417
22 16385451:gr A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. GeneRIF 9.463E-7 8.002E-4 8.328E-3 1.760E-2 9 418
23 23874603 HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis. Pubmed 1.061E-6 8.585E-4 8.936E-3 1.975E-2 6 135
24 24797263 Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. Pubmed 1.380E-6 1.070E-3 1.114E-2 2.568E-2 8 323
25 23246001 SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. Pubmed 2.145E-6 1.535E-3 1.598E-2 3.990E-2 7 239
26 20937905 ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. Pubmed 2.279E-6 1.535E-3 1.598E-2 4.239E-2 3 11
27 15164054 The DNA sequence and comparative analysis of human chromosome 10. Pubmed 2.398E-6 1.535E-3 1.598E-2 4.461E-2 8 348
28 23825951 Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing. Pubmed 2.838E-6 1.535E-3 1.598E-2
5.280E-2
4 40
29 18261733:gr Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER. GeneRIF 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
30 21822304 MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells. Pubmed 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
31 21544602:gr Increased elongase 6 and ¿9-desaturase activity are associated with n-7 and n-9 fatty acid changes in cystic fibrosis. GeneRIF 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
32 14633995:gr MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation. GeneRIF 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
33 21383846:gr Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition. GeneRIF 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
34 19196137:gr Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal stem cells. GeneRIF 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
35 22024489 A Mediterranean-style, low-glycemic-load diet reduces the expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in mononuclear cells and plasma insulin in women with metabolic syndrome. Pubmed 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
36 20458442 Tetra-glutamic acid residues adjacent to Lys248 in HMG-CoA reductase are critical for the ubiquitination mediated by gp78 and UBE2G2. Pubmed 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
37 21383846 Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition. Pubmed 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
38 14761977:gr MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53. GeneRIF 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
39 21822304:gr MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells. GeneRIF 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
40 19887822:gr Regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression by thymoquinone-rich fraction and thymoquinone in HepG2 cells. GeneRIF 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
41 17627285:gr Ceramide-induced G2 arrest in rhabdomyosarcoma (RMS) cells requires p21Cip1/Waf1 induction and is prevented by MDM2 overexpression. GeneRIF 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
42 3866240 Human genes involved in cholesterol metabolism: chromosomal mapping of the loci for the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase with cDNA probes. Pubmed 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
43 15644444 The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma. Pubmed 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
44 20308078:gr MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change. GeneRIF 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
45 12901493:gr Association between low-density lipoprotein receptor-related protein gene, butyrylcholinesterase gene and Alzheimer' s disease in Chinese. GeneRIF 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
46 20979563 MDM2 and CDKN1A gene polymorphisms and risk of Kaposi's sarcoma in African and Caucasian patients. Pubmed 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
47 15962316:gr A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism. GeneRIF 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
48 18261733 Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER. Pubmed 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
49 20413733 Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin. Pubmed 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
50 19887822 Regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression by thymoquinone-rich fraction and thymoquinone in HepG2 cells. Pubmed 5.858E-6 1.535E-3 1.598E-2
1.090E-1
2 2
Show 45 more annotations

9: Interaction [Display Chart] 3057 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:TCTN3 TCTN3 interactions 1.811E-5 2.971E-2
2.556E-1
5.536E-2
11 317
2 int:ISG15 ISG15 interactions 1.944E-5 2.971E-2
2.556E-1
5.942E-2
9 208

10: Cytoband [Display Chart] 121 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 5q23.2 5q23.2 2.585E-4 3.127E-2
1.682E-1
3.127E-2 3 34
2 2p13 2p13 3.434E-3 4.399E-2
2.365E-1
4.155E-1
2 24
3 1q25.1-q31.1 1q25.1-q31.1 3.635E-3 4.399E-2
2.365E-1
4.399E-1
1 1
4 4q13.3-q21.3 4q13.3-q21.3 3.635E-3 4.399E-2
2.365E-1
4.399E-1
1 1
5 18q21.1-q21.32 18q21.1-q21.32 3.635E-3 4.399E-2
2.365E-1
4.399E-1
1 1
6 12q14.3-q15 12q14.3-q15 3.635E-3 4.399E-2
2.365E-1
4.399E-1
1 1
7 11q12.2-q13.1 11q12.2-q13.1 3.635E-3 4.399E-2
2.365E-1
4.399E-1
1 1
8 10q21.3-q23.1 10q21.3-q23.1 3.635E-3 4.399E-2
2.365E-1
4.399E-1
1 1
9 14q24-q32 14q24-q32 3.635E-3 4.399E-2
2.365E-1
4.399E-1
1 1
10 10q11.1-q24 10q11.1-q24 3.635E-3 4.399E-2
2.365E-1
4.399E-1
1 1
11 Xq23-q24 Xq23-q24 7.257E-3 4.879E-2
2.623E-1
8.781E-1
1 2
12 8p23.1-p22 8p23.1-p22 7.257E-3 4.879E-2
2.623E-1
8.781E-1
1 2
13 5p14-p13 5p14-p13 7.257E-3 4.879E-2
2.623E-1
8.781E-1
1 2
14 6p21.1-p12.1 6p21.1-p12.1 7.257E-3 4.879E-2
2.623E-1
8.781E-1
1 2
15 12p12.3-p12.1 12p12.3-p12.1 7.257E-3 4.879E-2
2.623E-1
8.781E-1
1 2
16 5q13.3-q14 5q13.3-q14 7.257E-3 4.879E-2
2.623E-1
8.781E-1
1 2
17 10q23.2-q23.3 10q23.2-q23.3 7.257E-3 4.879E-2
2.623E-1
8.781E-1
1 2
18 9q34.13-q34.3 9q34.13-q34.3 7.257E-3 4.879E-2
2.623E-1
8.781E-1
1 2
Show 13 more annotations

11: Transcription Factor Binding Site [Display Chart] 473 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 66 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1324 STEAP family genenames.org 1.366E-4 9.019E-3 4.306E-2 9.019E-3 2 5
2 553 Fatty acid desaturases genenames.org 3.798E-4 1.253E-2
5.985E-2
2.507E-2 2 8
3 759 StAR related lipid transfer domain containing genenames.org 1.401E-3 2.979E-2
1.422E-1
9.243E-2
2 15
4 583 Heat shock 70kDa proteins genenames.org 1.805E-3 2.979E-2
1.422E-1
1.191E-1
2 17

13: Coexpression [Display Chart] 6061 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5924 Genes up-regulated through activation of mTORC1 complex. MSigDB H: Hallmark Gene Sets (v5.1) 1.100E-26 6.666E-23 6.191E-22 6.666E-23 25 200
2 M2383 Genes up-regulated in E12.5 forelimb buds with POR [GeneID=5447] knockout. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.208E-23 9.723E-20 9.030E-19 1.945E-19 13 26
3 M5892 Genes involved in cholesterol homeostasis. MSigDB H: Hallmark Gene Sets (v5.1) 5.726E-18 1.157E-14 1.074E-13 3.471E-14 14 74
4 M18058 Genes up-regulated in primary cultures of ovarian surface epithlium cells exposed to progesterone [PubChem=5994] for 5 days. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.513E-17 2.293E-14 2.130E-13 9.173E-14 17 152
5 M3009 Genes up-regulated in liver from mice transgenic for SREBF1 or SREBF2 [GeneID = 6720, 6721] and down-regulated in mice lacking SCAP [GeneID=22937]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.225E-17 8.758E-14 8.134E-13 4.379E-13 10 25
6 M8876 Down-regulated genes in MM1.S cells (multiple myeloma) treated with adaphostin [PubChem=387042], a tyrosine kinase inhibitor with anticancer properties. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.548E-14 3.584E-11 3.329E-10 2.151E-10 8 18
7 M2672 Genes up-regulated by everolimus [PubChem = 6442177] in prostate tissue. MSigDB C6: Oncogenic Signatures (v5.1) 4.693E-14 4.064E-11 3.774E-10 2.845E-10 15 170
8 M2659 Genes down-regulated in late serum response of CRL 2091 cells (foreskin fibroblasts). MSigDB C6: Oncogenic Signatures (v5.1) 8.201E-13 5.836E-10 5.420E-9 4.971E-9 14 169
9 M1918 Up-regulated genes in pediatric adrenocortical tumors (ACT) compared to the normal tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.667E-13 5.836E-10 5.420E-9 5.253E-9 17 293
10 M15148 Genes down-regulated in P14 nerves of transgenic mice having hypomorhic (reduced function) allele of EGR2 [GeneID=1959]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.132E-12 6.861E-10 6.371E-9 6.861E-9 12 108
11 M13936 Genes down-regulated in BJAB cells (B-lymphoma) after glutamine [PubChem=738] deprivation. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.105E-12 4.466E-9 4.148E-8 4.913E-8 17 337
12 M5908 Genes defining response to androgens. MSigDB H: Hallmark Gene Sets (v5.1) 1.283E-11 6.480E-9 6.018E-8 7.776E-8 11 101
13 M1885 Genes down-regulated in vascular smooth muscle cells (VSMC) by MAPK8 (JNK1) [GeneID=5599]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.976E-11 1.377E-8 1.279E-7 1.804E-7 17 366
14 M11189 IRF4 [GeneID=3662] target genes induced after activation of primary B lymphocytes by anti-IgM crosslinking. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.182E-11 1.377E-8 1.279E-7 1.928E-7 10 81
15 M1647 Genes up-regulated in liver from mice with liver specific knockout of POR [GeneID=5447]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.950E-11 2.808E-8 2.608E-7 4.212E-7 8 41
16 M6887 Genes down-regulated in monocytes after HCMV infection: BAY 11-7082 [PubChem=5353431] versus Ly294002 [PubChem=3973]. MSigDB C7: Immunologic Signatures (v5.1) 1.195E-10 4.528E-8 4.205E-7 7.244E-7 13 200
17 M2293 Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.325E-10 1.186E-7 1.101E-6 2.016E-6 15 315
18 M2631 Genes which best discriminate between two groups of breast cancer according the status of ESR1 and AR [GeneID=2099;367]: apocrine (ESR1- AR+) vs basal (ESR1- AR-). MSigDB C2: CGP Curated Gene Sets (v5.1) 6.323E-10 2.129E-7 1.977E-6 3.832E-6 15 330
19 M1471 Genes down-regulated in MEF cells (embryonic fibroblast) expressing ~25% of YY1 [GeneID=7528]. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.307E-10 2.650E-7 2.461E-6 5.035E-6 13 234
20 M1611 Genes up-regulated in liver from transgenic mice with reduced expression of POR [GeneID=5447] in all tissues. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.069E-9 3.239E-7 3.008E-6 6.479E-6 6 20
21 GSE32986 UNSTIM VS CURDLAN LOWDOSE STIM DC DN Genes down-regulated in bone marrow-derived dendritic cells: unstimulated versus low dose of 1,3-beta-D-oligoglucan [PubChem=11375554]. MSigDB C7: Immunologic Signatures (v5.1) 1.513E-9 3.883E-7 3.606E-6 9.167E-6 12 199
22 M1217 Genes consistently down-regulated in HMEC cells (primary mammary epithelium) upon expression of TERT [GeneID=7015] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.598E-9 3.883E-7 3.606E-6 9.687E-6 9 87
23 GSE42724 MEMORY VS B1 BCELL DN Genes down-regulated in B lymphocytes: memory versus B1. MSigDB C7: Immunologic Signatures (v5.1) 1.601E-9 3.883E-7 3.606E-6 9.706E-6 12 200
24 M3594 Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 24 h after stimulation with antigen-B7-1. MSigDB C7: Immunologic Signatures (v5.1) 1.601E-9 3.883E-7 3.606E-6 9.706E-6 12 200
25 M4386 Genes down-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from TLR4 [GeneID=7099] deficient mice subjected to ozone for 48 h. MSigDB C7: Immunologic Signatures (v5.1) 1.601E-9 3.883E-7 3.606E-6 9.706E-6 12 200
26 M5793 Down-regulated genes in the canonical gene expression signature of the fibroblast core serum response (CSR) defined by the Stanford group. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.641E-9 6.156E-7 5.717E-6 1.601E-5 12 209
27 M2132 Genes down-regulated in RS4;11 cells (MLL, mixed lineage leukemia) in response to SB216763 [PubChemID=176158], an inhibitor of GSK3B [GeneID=2932]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.489E-9 7.833E-7 7.275E-6 2.115E-5 15 374
28 M10355 Genes up-regulated in MCV152 cells (ovarian cancer) treated with follicle stimulating hormone (FSH). MSigDB C2: CGP Curated Gene Sets (v5.1) 9.380E-9 2.031E-6 1.886E-5 5.685E-5 8 74
29 M12104 Genes down-regulated in BJAB cells (B-lymphoma) after leucine [PubChem=857] deprivation. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.734E-9 2.034E-6 1.889E-5 5.900E-5 11 187
30 M17693 Genes up-regulated in Daudi cells (B lymphocytes) stably expressing CD5 [GeneID=921] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.139E-8 2.301E-6 2.137E-5 6.902E-5 16 473
31 M18854 Genes down-regulated in BJUB cells (B-lymphoma) in response to rapamycin [PubChem=6610346] treatment. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.572E-8 3.074E-6 2.855E-5 9.529E-5 12 245
32 GSE32986 GMCSF VS GMCSF AND CURDLAN LOWDOSE STIM DC UP Genes up-regulated in bone marrow-derived dendritic cells CSF2 [GeneID=1437] versus CSF2 [GeneID=1437] and low dose of 1,3-beta-D-oligoglucan [PubChem=11375554]. MSigDB C7: Immunologic Signatures (v5.1) 1.672E-8 3.167E-6 2.941E-5 1.013E-4 11 197
33 M2895 Genes up-regulated in MEF cells (embryonic fibroblasts) isolated from RB1 [GeneID=5925] knockout mice: chronic loss of function (LOF) of RB1. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.919E-8 3.202E-6 2.974E-5 1.163E-4 9 115
34 M5599 Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells versus those treated with IL1B [GeneID=3553] and IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v5.1) 1.955E-8 3.202E-6 2.974E-5 1.185E-4 11 200
35 M3588 Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 24 h. MSigDB C7: Immunologic Signatures (v5.1) 1.955E-8 3.202E-6 2.974E-5 1.185E-4 11 200
36 M3607 Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 72 h. MSigDB C7: Immunologic Signatures (v5.1) 1.955E-8 3.202E-6 2.974E-5 1.185E-4 11 200
37 M3610 Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 72 h after stimulation with IL12. MSigDB C7: Immunologic Signatures (v5.1) 1.955E-8 3.202E-6 2.974E-5 1.185E-4 11 200
38 M19745 Genes down-regulated in mature plasma cells compared with plasmablastic B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.260E-8 3.605E-6 3.348E-5 1.370E-4 13 308
39 M3447 Genes whose expression peaked at 60 min after stimulation of MCF10A cells with serum. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.322E-8 5.162E-6 4.794E-5 2.013E-4 7 57
40 M12498 Molecular timetable composed of 162 time-indicating genes (182 probes) in the peripheral (liver) clock. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.451E-8 6.744E-6 6.263E-5 2.698E-4 10 169
41 M13537 Genes up-regulated in MEWO cells (melanoma) after 48h of methionine [PubChem=876] deprivation. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.890E-8 7.075E-6 6.570E-5 2.964E-4 9 128
42 M2669 Genes up-regulated in mouse prostate by transgenic expression of human AKT1 gene [Gene ID=207] vs controls. MSigDB C6: Oncogenic Signatures (v5.1) 4.975E-8 7.075E-6 6.570E-5 3.016E-4 10 171
43 M1613 Transcripts depleted in pseudopodia of NIH/3T3 cells (fibroblast) in response to the chemotactic migration stimulus by lysophosphatidic acid (LPA) [PubChem=3988]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.019E-8 7.075E-6 6.570E-5 3.042E-4 15 457
44 GSE37301 PRO BCELL VS GRANULOCYTE MONOCYTE PROGENITOR DN Genes down-regulated in pro-B cells versus granulocyte-monocyte progenitors. MSigDB C7: Immunologic Signatures (v5.1) 5.257E-8 7.242E-6 6.726E-5 3.187E-4 10 172
45 M2408 Genes regulated in MCF7 cells (breast cancer) by expression of the truncated (611-CTF) form of ERBB2 [GeneID=2064] at both 15 h and 60 h time points. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.830E-8 1.055E-5 9.794E-5 4.746E-4 5 20
46 M19541 Genes commonly down-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.387E-8 1.105E-5 1.026E-4 5.084E-4 14 408
47 M2434 Transcripts dependent upon IRS1 and IRS2 [GeneID=3667, 8660] for normal expression in liver. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.745E-8 1.128E-5 1.047E-4 5.301E-4 8 98
48 M2133 Genes up-regulated by hypoxia in TRAMP-C cells (prostatic cancer). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.061E-7 1.340E-5 1.245E-4 6.432E-4 9 140
49 M11156 Genes down-regulated in normal tissue adjacent to liver tumor, compared to the normal liver samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.148E-7 1.419E-5 1.318E-4 6.955E-4 13 354
50 M15193 Genes up-regulated in pancreatic ductal adenocarcinoma (PDAC) identified in a meta analysis across four independent studies. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.306E-7 1.583E-5 1.471E-4 7.917E-4 13 358
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2799 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap dev gonad e13.5 M gudmap devVasTestis Flk k1 500 dev gonad e13.5 M DevVasTestis Flk k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 5.889E-10 1.372E-6 1.168E-5 1.648E-6 8 50
2 OPC Top 500 All OPC Top 500 All Brain Map - Barres 9.804E-10 1.372E-6 1.168E-5 2.744E-6 18 494
3 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 1.088E-8 1.015E-5 8.642E-5 3.045E-5 16 445
4 gudmap dev gonad e13.5 M gudmap devVasTestis Flk k1 1000 dev gonad e13.5 M DevVasTestis Flk k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 7.007E-8 4.903E-5 4.174E-4 1.961E-4 6 36
5 gudmap kidney e15.5 Podocyte MafB 500 kidney e15.5 Podocyte MafB top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.969E-7 9.741E-5 8.294E-4 5.512E-4 14 413
6 GSM605805 500 gamma delta T cells, Tgd.vg5+.IEL, CD8a+ CD8b- TCRd+ Vg5+ CD44lo, Small Intestine, avg-3 Immgen.org, GSE15907 2.088E-7 9.741E-5 8.294E-4 5.845E-4 14 415
7 54SK Top 500 All 54SK Top 500 All Brain Map - Allen iN 2.473E-7 9.887E-5 8.418E-4 6.921E-4 15 488
8 gudmap dev gonad e13.5 M gudmap devVasTestis Flk 500 dev gonad e13.5 M DevVasTestis Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.208E-7 1.122E-4 9.556E-4 8.979E-4 14 430
9 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 4.004E-7 1.245E-4 1.060E-3 1.121E-3 14 438
10 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 5.990E-7 1.468E-4 1.250E-3 1.677E-3 14 453
11 54Dn SubClass 54Dn 1SK Top 500 Cluster 2 54Dn SubClass 54Dn 1SK Top 500 Cluster 2 Brain Map - Allen iN 6.002E-7 1.468E-4 1.250E-3 1.680E-3 11 265
12 Lungmap Mouse p107 AT2 Epithelial (GSE52583) Top 500 All Mouse Lung p107 Epithelial Adult AT2 top 500 Lungmap Mouse Single Cell (Lungmap.net) 6.293E-7 1.468E-4 1.250E-3 1.761E-3 13 388
13 GSM605811 500 gamma delta T cells, Tgd.vg5-.IEL, CD8a+ CD8b- TCRgd+ Vg5- CD44lo, Small Intestine, avg-3 Immgen.org, GSE15907 1.017E-6 2.190E-4 1.865E-3 2.847E-3 13 405
14 54Dn SubClass 54Dn 4 Top 500 All 54Dn SubClass 54Dn 4 Top 500 All Brain Map - Allen iN 1.410E-6 2.761E-4 2.351E-3 3.947E-3 14 487
15 endothelial SubClass endothelial all Top 500 All endothelial SubClass endothelial all Top 500 All Brain Map - Barres 1.480E-6 2.761E-4 2.351E-3 4.141E-3 14 489
16 26Dn SubClass 26Dn 2 Top 500 All 26Dn SubClass 26Dn 2 Top 500 All Brain Map - Allen iN 1.831E-6 3.204E-4 2.728E-3 5.126E-3 14 498
17 GSM791102 500 Stem Cells, SC.LT34F.BM, Lineage- cKit+ Sca-1+ flk2- CD34-, Bone marrow, avg-3 Immgen.org, GSE15907 2.116E-6 3.485E-4 2.967E-3 5.924E-3 12 365
18 gudmap dev gonad e13.5 M gudmap devVasTestis Flk k4 1000 dev gonad e13.5 M DevVasTestis Flk k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.163E-6 4.776E-4 4.067E-3 8.854E-3 8 148
19 gudmap dev gonad e13.5 M InterstitFLeydig MafB k2 1000 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.337E-6 4.776E-4 4.067E-3 9.339E-3 7 105
20 GSM538280 500 Myeloid Cells, DC.LC.Sk, MHCII+ CD11b+ CD45+, Skin, avg-2 Immgen.org, GSE15907 3.413E-6 4.776E-4 4.067E-3 9.553E-3 13 452
21 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 4.228E-6 5.636E-4 4.799E-3 1.184E-2 13 461
22 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 4.864E-6 6.097E-4 5.191E-3 1.361E-2 13 467
23 gudmap developingLowerUrinaryTract e14.5 bladder 1000 k5 DevelopingLowerUrinaryTract e14.5 bladder emap-30872 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.010E-6 6.097E-4 5.191E-3 1.402E-2 12 397
24 GSM605802 500 gamma delta T cells, Tgd.vg5+.act.IEL, CD8a+ CD8b- TCRd+ Vg5+ CD44hi, Small Intestine, avg-3 Immgen.org, GSE15907 6.944E-6 8.098E-4 6.895E-3 1.944E-2 12 410
25 fetal quiescent Top 500 All fetal quiescent Top 500 All Brain Map - Barres 7.979E-6 8.654E-4 7.368E-3 2.233E-2 13 489
26 GSM791146 500 alpha beta T cells, preT.DN3A.Th, Lin-/lo CD25hi CD44- CD28-, Thymus, avg-3 Immgen.org, GSE15907 8.038E-6 8.654E-4 7.368E-3 2.250E-2 12 416
27 gudmap dev gonad e11.5 M GonadVasMes Flk 500 dev gonad e11.5 M GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.640E-6 8.787E-4 7.482E-3 2.418E-2 12 419
28 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 9.286E-6 8.787E-4 7.482E-3 2.599E-2 13 496
29 GSM399454 500 Stem Cells, SC.STSL.BM, CD117+ IL7R- CD150- CD48- AA4.1+ CD43+, Bone marrow, avg-3 Immgen.org, GSE15907 9.505E-6 8.787E-4 7.482E-3 2.660E-2 12 423
30 26Dn SubClass 26Dn 4 Top 500 Cluster 0 26Dn SubClass 26Dn 4 Top 500 Cluster 0 Brain Map - Allen iN 9.523E-6 8.787E-4 7.482E-3 2.666E-2 7 123
31 gudmap dev gonad e11.5 F GonadVasMes Flk 500 dev gonad e11.5 F GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 9.732E-6 8.787E-4 7.482E-3 2.724E-2 12 424
32 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB 500 dev gonad e13.5 F VascAssocMesenchStromOvary MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.085E-5 9.490E-4 8.080E-3 3.037E-2 11 358
33 endothelial SubClass endothelial all Top 500 Cluster 3 endothelial SubClass endothelial all Top 500 Cluster 3 Brain Map - Barres 1.324E-5 1.123E-3 9.560E-3 3.705E-2 6 86
34 gudmap dev gonad e12.5 M SertoliCell Sox9 500 dev gonad e12.5 M SertoliCell Sox9 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.440E-5 1.176E-3 1.001E-2 4.031E-2 12 441
35 gudmap developingLowerUrinaryTract e14.5 bladder 1000 k4 DevelopingLowerUrinaryTract e14.5 bladder emap-30872 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.511E-5 1.176E-3 1.001E-2 4.230E-2 7 132
36 gudmap kidney adult RenalCapsule k2 1000 kidney adult RenalCapsule k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.513E-5 1.176E-3 1.001E-2 4.234E-2 11 371
37 GSM777063 500 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.759E-5 1.331E-3 1.133E-2 4.924E-2 12 450
38 Facebase RNAseq e10.5 Lateral Nasal Eminence 500 K4 FacebaseRNAseq e10.5 Lateral Nasal Eminence top-relative-expression-ranked 500 k-means-cluster#4 FaceBase_RNAseq 2.130E-5 1.569E-3 1.336E-2
5.962E-2
8 192
39 gudmap developingKidney e14.5 whole kidney - wildtype 1000 k2 DevelopingKidney e14.5 whole kidney - wildtype emap-6674 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.776E-5 1.992E-3 1.696E-2
7.769E-2
7 145
40 54Dn SubClass 54Dn 4 Top 500 Cluster 3 54Dn SubClass 54Dn 4 Top 500 Cluster 3 Brain Map - Allen iN 3.283E-5 2.298E-3 1.956E-2
9.190E-2
5 61
41 54SK SubClass 54SK 1 Top 500 Cluster 4 54SK SubClass 54SK 1 Top 500 Cluster 4 Brain Map - Allen iN 3.445E-5 2.352E-3 2.003E-2
9.644E-2
4 31
42 GSM476663 500 Stem Cells, SC.LTSL.BM, CD117+ IL7R- CD150+ CD48- AA4.1+ CD43+, Bone marrow, avg-1 Immgen.org, GSE15907 3.701E-5 2.467E-3 2.100E-2
1.036E-1
11 409
43 GSM854335 500 alpha beta T cells, preT.ETP.Th, Lin-/lo CD25- CD44+ cKit+, Thymus, avg-3 Immgen.org, GSE15907 4.223E-5 2.728E-3 2.322E-2
1.182E-1
11 415
44 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 4.288E-5 2.728E-3 2.322E-2
1.200E-1
12 493
45 GSM476664 500 gamma delta T cells, Tgd.vg3+24alo.e17.Th, TCRd+ Vg3+ CD24-, Fetal Thymus, avg-3 Immgen.org, GSE15907 4.605E-5 2.865E-3 2.439E-2
1.289E-1
11 419
46 gudmap developingLowerUrinaryTract e14.5 bladder 500 DevelopingLowerUrinaryTract e14.5 bladder emap-30872 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.807E-5 2.925E-3 2.491E-2
1.346E-1
11 421
47 GSM538282 500 Myeloid Cells, MF.Lu, CD11chi CD11b- CD103- MHCII- SiglecF+, Lung, avg-3 Immgen.org, GSE15907 5.234E-5 3.117E-3 2.654E-2
1.465E-1
11 425
48 gudmap dev gonad e13.5 M SertoliCell Sox9 500 dev gonad e13.5 M SertoliCell Sox9 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.187E-5 3.608E-3 3.072E-2
1.732E-1
11 433
49 BM Top 100 - heart ventricle BM Top 100 - heart ventricle Body Map 6.850E-5 3.913E-3 3.331E-2
1.917E-1
5 71
50 GSM777059 500 Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 6.996E-5 3.916E-3 3.334E-2
1.958E-1
11 439
Show 45 more annotations

15: Computational [Display Chart] 392 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 432 Genes in module 432 MSigDb: C4 - CM: Cancer Modules 3.761E-13 1.474E-10 9.656E-10 1.474E-10 8 15
2 module 3 Genes in module 3 MSigDb: C4 - CM: Cancer Modules 2.629E-9 5.153E-7 3.375E-6 1.031E-6 19 375
3 module 17 Genes in module 17 MSigDb: C4 - CM: Cancer Modules 1.460E-6 1.663E-4 1.089E-3 5.721E-4 15 353
4 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 1.931E-6 1.663E-4 1.089E-3 7.568E-4 15 361
5 module 212 Genes in module 212 MSigDb: C4 - CM: Cancer Modules 2.419E-6 1.663E-4 1.089E-3 9.482E-4 14 320
6 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 2.546E-6 1.663E-4 1.089E-3 9.980E-4 16 419
7 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 3.412E-6 1.911E-4 1.251E-3 1.337E-3 15 378
8 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 1.331E-5 6.523E-4 4.272E-3 5.218E-3 15 423
9 module 177 Genes in module 177 MSigDb: C4 - CM: Cancer Modules 5.571E-5 2.426E-3 1.589E-2 2.184E-2 7 101
10 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 1.497E-4 5.343E-3 3.500E-2
5.869E-2
12 351
11 module 8 Genes in module 8 MSigDb: C4 - CM: Cancer Modules 1.499E-4 5.343E-3 3.500E-2
5.877E-2
13 406
12 module 16 Genes in module 16 MSigDb: C4 - CM: Cancer Modules 2.989E-4 9.213E-3
6.035E-2
1.172E-1
14 495
13 module 509 Genes in module 509 MSigDb: C4 - CM: Cancer Modules 3.055E-4 9.213E-3
6.035E-2
1.198E-1
3 14
14 module 239 Genes in module 239 MSigDb: C4 - CM: Cancer Modules 8.926E-4 2.499E-2
1.637E-1
3.499E-1
6 115
15 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 1.214E-3 3.173E-2
2.078E-1
4.760E-1
8 216
16 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 1.579E-3 3.868E-2
2.533E-1
6.188E-1
11 395
Show 11 more annotations

16: MicroRNA [Display Chart] 1178 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 miR-101:PicTar miR-101:PicTar PicTar 1.641E-5 1.272E-2
9.729E-2
1.933E-2 12 430
2 GTACTGT,MIR-101:MSigDB GTACTGT,MIR-101:MSigDB MSigDB 2.159E-5 1.272E-2
9.729E-2
2.544E-2 9 242
3 hsa-miR-646:PITA hsa-miR-646:PITA TOP PITA 9.459E-5 2.417E-2
1.848E-1
1.114E-1
11 437
4 ATACCTC,MIR-202:MSigDB ATACCTC,MIR-202:MSigDB MSigDB 9.716E-5 2.417E-2
1.848E-1
1.145E-1
7 170
5 hsa-miR-125a:miRTarbase hsa-miR-125a:miRTarbase miRTarbase 1.026E-4 2.417E-2
1.848E-1
1.208E-1
3 15
6 TGTGTGA,MIR-377:MSigDB TGTGTGA,MIR-377:MSigDB MSigDB 1.589E-4 2.808E-2
2.148E-1
1.871E-1
7 184
7 hsa-miR-489:PITA hsa-miR-489:PITA TOP PITA 2.064E-4 2.808E-2
2.148E-1
2.431E-1
7 192
8 hsa-miR-101:PITA hsa-miR-101:PITA TOP PITA 2.106E-4 2.808E-2
2.148E-1
2.481E-1
11 479
9 GGCAGTG,MIR-324-3P:MSigDB GGCAGTG,MIR-324-3P:MSigDB MSigDB 2.156E-4 2.808E-2
2.148E-1
2.540E-1
5 87
10 hsa-miR-376a:PITA hsa-miR-376a:PITA TOP PITA 3.076E-4 2.808E-2
2.148E-1
3.624E-1
7 205
11 hsa-miR-376b:PITA hsa-miR-376b:PITA TOP PITA 3.076E-4 2.808E-2
2.148E-1
3.624E-1
7 205
12 hsa-miR-499-3p:PITA hsa-miR-499-3p:PITA TOP PITA 3.214E-4 2.808E-2
2.148E-1
3.786E-1
9 345
13 miR-23a:PicTar miR-23a:PicTar PicTar 3.215E-4 2.808E-2
2.148E-1
3.787E-1
10 422
14 miR-23b:PicTar miR-23b:PicTar PicTar 3.337E-4 2.808E-2
2.148E-1
3.931E-1
10 424
15 TTTTGAG,MIR-373:MSigDB TTTTGAG,MIR-373:MSigDB MSigDB 3.767E-4 2.958E-2
2.263E-1
4.438E-1
7 212
16 hsa-miR-202:PITA hsa-miR-202:PITA TOP PITA 4.964E-4 3.303E-2
2.526E-1
5.848E-1
7 222
17 ACTGTGA,MIR-27B:MSigDB ACTGTGA,MIR-27B:MSigDB MSigDB 5.046E-4 3.303E-2
2.526E-1
5.945E-1
10 447
18 ACTGTGA,MIR-27A:MSigDB ACTGTGA,MIR-27A:MSigDB MSigDB 5.046E-4 3.303E-2
2.526E-1
5.945E-1
10 447
19 hsa-miR-146b:miRTarbase hsa-miR-146b:miRTarbase miRTarbase 5.715E-4 3.425E-2
2.619E-1
6.733E-1
2 6
20 miR-31:PicTar miR-31:PicTar PicTar 5.814E-4 3.425E-2
2.619E-1
6.849E-1
6 164
21 hsa-miR-28-3p:PITA hsa-miR-28-3p:PITA TOP PITA 6.599E-4 3.596E-2
2.751E-1
7.773E-1
6 168
22 hsa-miR-502-3p:PITA hsa-miR-502-3p:PITA TOP PITA 6.807E-4 3.596E-2
2.751E-1
8.019E-1
6 169
23 hsa-miR-501-3p:PITA hsa-miR-501-3p:PITA TOP PITA 7.021E-4 3.596E-2
2.751E-1
8.270E-1
6 170
24 hsa-miR-129-3p:PITA hsa-miR-129-3p:PITA TOP PITA 7.493E-4 3.658E-2
2.798E-1
8.827E-1
7 238
25 miR-25:PicTar miR-25:PicTar PicTar 7.763E-4 3.658E-2
2.798E-1
9.145E-1
8 312
26 AATGTGA,MIR-23A:MSigDB AATGTGA,MIR-23A:MSigDB MSigDB 8.644E-4 3.735E-2
2.857E-1
1.000E0
9 396
27 AATGTGA,MIR-23B:MSigDB AATGTGA,MIR-23B:MSigDB MSigDB 8.644E-4 3.735E-2
2.857E-1
1.000E0
9 396
28 miR-205:PicTar miR-205:PicTar PicTar 8.879E-4 3.735E-2
2.857E-1
1.000E0
7 245
29 miR-145:PicTar miR-145:PicTar PicTar 9.310E-4 3.782E-2
2.893E-1
1.000E0
7 247
30 miR-125b:PicTar miR-125b:PicTar PicTar 1.179E-3 4.631E-2
3.542E-1
1.000E0
9 414
31 miR-125a:PicTar miR-125a:PicTar PicTar 1.261E-3 4.790E-2
3.664E-1
1.000E0
9 418
32 miR-199a-star:PicTar miR-199a-star:PicTar PicTar 1.346E-3 4.956E-2
3.791E-1
1.000E0
9 422
Show 27 more annotations

17: Drug [Display Chart] 19907 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 D005228 Fatty Acids, Essential CTD 1.746E-21 3.475E-17 3.641E-16 3.475E-17 15 58
2 CID000001107 sterol Stitch 1.061E-19 1.056E-15 1.106E-14 2.112E-15 22 265
3 C519728 archazolid B CTD 1.772E-15 9.693E-12 1.015E-10 3.528E-11 12 65
4 1105 UP monensin; Up 200; 10.9uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.948E-15 9.693E-12 1.015E-10 3.877E-11 16 170
5 D005395 Fish Oils CTD 3.727E-15 1.484E-11 1.554E-10 7.419E-11 15 145
6 CID000000856 tirucallol Stitch 3.365E-14 1.117E-10 1.170E-9 6.700E-10 12 82
7 CID000247705 AC1L6KTW Stitch 3.428E-13 8.890E-10 9.313E-9 6.824E-9 11 74
8 C018406 1-(3-trifluoromethylphenyl)piperazine CTD 3.573E-13 8.890E-10 9.313E-9 7.112E-9 8 23
9 3443 UP Monensin sodium salt [22373-78-0]; Up 200; 5.8uM; MCF7; HT HG-U133A Broad Institute CMAP 6.573E-13 1.454E-9 1.523E-8 1.308E-8 14 168
10 CID000003962 Epi Lovastatin Stitch 7.340E-13 1.461E-9 1.531E-8 1.461E-8 18 341
11 D005411 Flame Retardants CTD 1.246E-12 2.256E-9 2.363E-8 2.481E-8 14 176
12 D007529 Isoflavones CTD 1.454E-12 2.413E-9 2.527E-8 2.895E-8 15 217
13 C461488 N-benzylpiperazine CTD 3.464E-12 5.305E-9 5.558E-8 6.897E-8 10 66
14 D002110 Caffeine CTD 4.019E-12 5.714E-9 5.986E-8 8.000E-8 20 490
15 C078092 1-piperonylpiperazine CTD 8.482E-12 1.055E-8 1.106E-7 1.689E-7 9 50
16 C003585 22-hydroxycholesterol CTD 8.482E-12 1.055E-8 1.106E-7 1.689E-7 9 50
17 C002994 ethylene dimethanesulfonate CTD 1.234E-11 1.445E-8 1.514E-7 2.456E-7 9 52
18 1276 DN Dequalinium dichloride [522-51-0]; Down 200; 7.6uM; HL60; HT HG-U133A Broad Institute CMAP 1.830E-11 2.023E-8 2.120E-7 3.642E-7 13 174
19 C483161 beta-hydroxy simvastatin acid CTD 1.953E-11 2.046E-8 2.143E-7 3.888E-7 10 78
20 7178 UP Tetrandrine [518-34-3]; Up 200; 6.4uM; MCF7; HT HG-U133A Broad Institute CMAP 2.271E-11 2.261E-8 2.368E-7 4.521E-7 13 177
21 C016527 isoquercitrin CTD 2.635E-11 2.498E-8 2.617E-7 5.245E-7 8 37
22 2410 UP Perhexiline maleate [6724-53-4]; Up 200; 10.2uM; HL60; HT HG-U133A Broad Institute CMAP 2.808E-11 2.541E-8 2.662E-7 5.589E-7 13 180
23 D015056 1-Methyl-3-isobutylxanthine CTD 7.106E-11 6.150E-8 6.443E-7 1.415E-6 17 391
24 D008148 Lovastatin CTD 8.178E-11 6.783E-8 7.106E-7 1.628E-6 13 196
25 CID000000449 m vs Stitch 1.078E-10 8.587E-8 8.996E-7 2.147E-6 14 245
26 D005944 Glucosamine CTD 1.927E-10 1.475E-7 1.545E-6 3.836E-6 15 306
27 2456 UP Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; HL60; HT HG-U133A Broad Institute CMAP 2.876E-10 2.120E-7 2.221E-6 5.725E-6 12 174
28 C013698 tallow CTD 3.186E-10 2.265E-7 2.373E-6 6.343E-6 14 266
29 CID000000317 CoA group Stitch 3.431E-10 2.355E-7 2.467E-6 6.830E-6 17 433
30 6919 UP scriptaid; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 5.482E-10 3.638E-7 3.811E-6 1.091E-5 12 184
31 CID000092746 zymosterol Stitch 7.004E-10 4.498E-7 4.712E-6 1.394E-5 7 34
32 CID000000172 7-dehydrocholesterol Stitch 7.636E-10 4.751E-7 4.977E-6 1.520E-5 9 81
33 CID000000084 3-hydroxy-3-methylglutaryl-CoA Stitch 8.562E-10 5.165E-7 5.411E-6 1.704E-5 13 237
34 D001973 Bromodeoxyuridine CTD 1.322E-9 7.739E-7 8.108E-6 2.631E-5 7 37
35 2651 UP Suloctidil [54063-56-8]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP 1.388E-9 7.895E-7 8.270E-6 2.763E-5 11 157
36 2227 UP Terfenadine [50679-08-8]; Up 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.813E-9 1.002E-6 1.050E-5 3.609E-5 11 161
37 1486 UP Thioridazine hydrochloride [130-61-0]; Up 200; 9.8uM; MCF7; HT HG-U133A Broad Institute CMAP 1.936E-9 1.041E-6 1.091E-5 3.854E-5 11 162
38 1053 UP prochlorperazine dimaleate salt; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 2.506E-9 1.313E-6 1.375E-5 4.988E-5 11 166
39 D002793 Cholic Acids CTD 2.577E-9 1.316E-6 1.378E-5 5.131E-5 10 127
40 CID000000420 7 cholesterol Stitch 2.663E-9 1.325E-6 1.388E-5 5.300E-5 8 64
41 C032910 triadimefon CTD 2.926E-9 1.421E-6 1.488E-5 5.825E-5 15 373
42 D015741 Metribolone CTD 3.504E-9 1.661E-6 1.740E-5 6.975E-5 15 378
43 D002784 Cholesterol CTD 3.597E-9 1.665E-6 1.744E-5 7.160E-5 12 217
44 D003314 Corn Oil CTD 4.914E-9 2.223E-6 2.329E-5 9.781E-5 8 69
45 2830 UP Norcyclobenzaprine [303-50-4]; Up 200; 15.4uM; MCF7; HT HG-U133A Broad Institute CMAP 5.539E-9 2.450E-6 2.567E-5 1.103E-4 11 179
46 C423915 TO-901317 CTD 6.075E-9 2.629E-6 2.754E-5 1.209E-4 9 102
47 1755 DN Papaverine hydrochloride [61-25-6]; Down 200; 10.6uM; HL60; HG-U133A Broad Institute CMAP 6.222E-9 2.636E-6 2.761E-5 1.239E-4 11 181
48 1365 UP Astemizole [68844-77-9]; Up 200; 8.8uM; HL60; HG-U133A Broad Institute CMAP 7.819E-9 3.243E-6 3.397E-5 1.557E-4 11 185
49 6807 UP Astemizole [68844-77-9]; Up 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP 1.469E-8 5.969E-6 6.253E-5 2.925E-4 10 152
50 CID000000929 beta-NADP Stitch 1.614E-8 6.428E-6 6.734E-5 3.214E-4 16 490
Show 45 more annotations

18: Disease [Display Chart] 1573 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C1517445 Ganglioneuroblastoma, Nodular DisGeNET BeFree 1.437E-6 1.874E-3 1.487E-2 2.260E-3 3 4
2 umls:C1514225 Poorly Differentiated Neuroblastoma DisGeNET BeFree 3.573E-6 1.874E-3 1.487E-2 5.621E-3 3 5
3 umls:C0265267 Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects DisGeNET Curated 3.573E-6 1.874E-3 1.487E-2 5.621E-3 3 5
4 umls:C0553580 Ewings sarcoma DisGeNET Curated 2.472E-5 9.719E-3
7.716E-2
3.888E-2 9 215
5 umls:C1865596 Desmosterolosis DisGeNET Curated 5.115E-5 1.341E-2
1.064E-1
8.046E-2
2 2
6 umls:C3151781 CK SYNDROME DisGeNET Curated 5.115E-5 1.341E-2
1.064E-1
8.046E-2
2 2
7 umls:C0940937 precancerous lesions DisGeNET BeFree 1.147E-4 2.402E-2
1.907E-1
1.804E-1
6 106
8 umls:C0020443 Hypercholesterolemia DisGeNET Curated 1.274E-4 2.402E-2
1.907E-1
2.003E-1
7 155
9 umls:C1846421 Lathosterolosis DisGeNET Curated 1.527E-4 2.402E-2
1.907E-1
2.402E-1
2 3
10 umls:C1708550 Intimal sarcoma DisGeNET BeFree 1.527E-4 2.402E-2
1.907E-1
2.402E-1
2 3
11 umls:C0206718 Ganglioneuroblastoma DisGeNET BeFree 2.512E-4 3.592E-2
2.852E-1
3.952E-1
4 43
12 20090112:Kathiresan HDL cholesterol GWAS 3.000E-4 3.679E-2
2.920E-1
4.718E-1
4 45
13 umls:C0242216 Biliary calculi DisGeNET Curated 3.040E-4 3.679E-2
2.920E-1
4.782E-1
2 4
14 umls:C0281361 Adenocarcinoma of pancreas DisGeNET BeFree 3.889E-4 4.302E-2
3.415E-1
6.118E-1
9 309
15 umls:C0280324 Laryngeal Squamous Cell Carcinoma DisGeNET Curated 4.102E-4 4.302E-2
3.415E-1
6.453E-1
6 134
16 umls:C0024667 Animal Mammary Neoplasms DisGeNET Curated 4.798E-4 4.717E-2
3.744E-1
7.547E-1
6 138
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