Toppgene analysis for aggregated_1964_log, IC25, negative side

Go To Start Page
Input Parameters [Show Detail]
Training Results [Expand All] [Download All] [Sparse Matrix]
Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 250 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0048407 platelet-derived growth factor binding 8.462E-6 2.115E-3 1.291E-2 2.115E-3 3 12
2 GO:0005518 collagen binding 1.118E-4 1.245E-2
7.594E-2
 2.795E-2 4 72
3 GO:0043425 bHLH transcription factor binding 1.494E-4 1.245E-2
7.594E-2
 3.734E-2 3 30
4 GO:0046977 TAP binding 2.439E-4 1.525E-2
9.301E-2
6.099E-2
 2 7
5 GO:0050839 cell adhesion molecule binding 7.746E-4 3.210E-2
1.958E-1
1.937E-1
 5 209
6 GO:0005178 integrin binding 8.388E-4 3.210E-2
1.958E-1
2.097E-1
 4 122
7 GO:0005159 insulin-like growth factor receptor binding 1.198E-3 3.210E-2
1.958E-1
2.995E-1
 2 15
8 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1.286E-3 3.210E-2
1.958E-1
3.215E-1
 3 62
9 GO:0005080 protein kinase C binding 1.286E-3 3.210E-2
1.958E-1
3.215E-1
 3 62
10 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding 1.460E-3 3.210E-2
1.958E-1
3.650E-1
 6 358
11 GO:0019838 growth factor binding 1.473E-3 3.210E-2
1.958E-1
3.682E-1
 4 142
12 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1.541E-3 3.210E-2
1.958E-1
3.852E-1
 3 66
13 GO:0052813 phosphatidylinositol bisphosphate kinase activity 1.979E-3 3.598E-2
2.195E-1
4.947E-1
 3 72
14 GO:0035004 phosphatidylinositol 3-kinase activity 2.398E-3 3.598E-2
2.195E-1
5.994E-1
 3 77
15 GO:0030339 fatty-acyl-ethyl-ester synthase activity 3.454E-3 3.598E-2
2.195E-1
8.635E-1
 1 1
16 GO:0030760 pyridine N-methyltransferase activity 3.454E-3 3.598E-2
2.195E-1
8.635E-1
 1 1
17 GO:0008112 nicotinamide N-methyltransferase activity 3.454E-3 3.598E-2
2.195E-1
8.635E-1
 1 1
18 GO:0047982 homocysteine desulfhydrase activity 3.454E-3 3.598E-2
2.195E-1
8.635E-1
 1 1
19 GO:0004123 cystathionine gamma-lyase activity 3.454E-3 3.598E-2
2.195E-1
8.635E-1
 1 1
20 GO:0016856 racemase and epimerase activity, acting on hydroxy acids and derivatives 3.454E-3 3.598E-2
2.195E-1
8.635E-1
 1 1
21 GO:0080146 L-cysteine desulfhydrase activity 3.454E-3 3.598E-2
2.195E-1
8.635E-1
 1 1
22 GO:0008809 carnitine racemase activity 3.454E-3 3.598E-2
2.195E-1
8.635E-1
 1 1
23 GO:0004121 cystathionine beta-lyase activity 3.454E-3 3.598E-2
2.195E-1
8.635E-1
 1 1
24 GO:0044540 L-cystine L-cysteine-lyase (deaminating) 3.454E-3 3.598E-2
2.195E-1
8.635E-1
 1 1
25 GO:0005516 calmodulin binding 4.298E-3 4.298E-2
2.622E-1
1.000E0
 4 191
Show 20 more annotations

2: GO: Biological Process [Display Chart] 2178 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001503 ossification 1.033E-5 1.579E-2
1.305E-1
 2.249E-2 9 406
2 GO:0030198 extracellular matrix organization 2.909E-5 1.579E-2
1.305E-1
6.337E-2
 8 354
3 GO:0043062 extracellular structure organization 2.968E-5 1.579E-2
1.305E-1
6.465E-2
 8 355
4 GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent 3.529E-5 1.579E-2
1.305E-1
7.686E-2
 2 3
5 GO:0048641 regulation of skeletal muscle tissue development 3.625E-5 1.579E-2
1.305E-1
7.896E-2
 4 54
6 GO:0045669 positive regulation of osteoblast differentiation 9.003E-5 3.268E-2
2.701E-1
1.961E-1
 4 68
7 GO:0035909 aorta morphogenesis 1.218E-4 3.789E-2
3.131E-1
2.652E-1
 3 28
Show 2 more annotations

3: GO: Cellular Component [Display Chart] 215 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031901 early endosome membrane 4.555E-5 4.918E-3 2.926E-2 9.794E-3 5 114
2 GO:0005578 proteinaceous extracellular matrix 4.575E-5 4.918E-3 2.926E-2 9.836E-3 8 379
3 GO:0044440 endosomal part 1.177E-4 5.919E-3 3.522E-2 2.530E-2 8 434
4 GO:0044420 extracellular matrix component 1.334E-4 5.919E-3 3.522E-2 2.869E-2 5 143
5 GO:0031012 extracellular matrix 1.376E-4 5.919E-3 3.522E-2 2.959E-2 8 444
6 GO:0010008 endosome membrane 4.344E-4 1.473E-2
8.762E-2
9.339E-2
 7 399
7 GO:0031983 vesicle lumen 5.247E-4 1.473E-2
8.762E-2
1.128E-1
 4 108
8 GO:0042612 MHC class I protein complex 6.292E-4 1.473E-2
8.762E-2
1.353E-1
 2 11
9 GO:0005788 endoplasmic reticulum lumen 7.322E-4 1.473E-2
8.762E-2
1.574E-1
 5 207
10 GO:0005583 fibrillar collagen trimer 7.534E-4 1.473E-2
8.762E-2
1.620E-1
 2 12
11 GO:0098643 banded collagen fibril 7.534E-4 1.473E-2
8.762E-2
1.620E-1
 2 12
12 GO:0030122 AP-2 adaptor complex 8.884E-4 1.488E-2
8.852E-2
1.910E-1
 2 13
13 GO:0031093 platelet alpha granule lumen 8.996E-4 1.488E-2
8.852E-2
1.934E-1
 3 55
14 GO:0030128 clathrin coat of endocytic vesicle 1.034E-3 1.588E-2
9.450E-2
2.223E-1
 2 14
15 GO:0030662 coated vesicle membrane 1.457E-3 2.088E-2
1.242E-1
3.132E-1
 4 142
16 GO:0030133 transport vesicle 1.796E-3 2.311E-2
1.375E-1
3.861E-1
 6 374
17 GO:0030132 clathrin coat of coated pit 1.922E-3 2.311E-2
1.375E-1
4.132E-1
 2 19
18 GO:0030666 endocytic vesicle membrane 2.103E-3 2.311E-2
1.375E-1
4.522E-1
 4 157
19 GO:0031091 platelet alpha granule 2.205E-3 2.311E-2
1.375E-1
4.740E-1
 3 75
20 GO:0030139 endocytic vesicle 2.221E-3 2.311E-2
1.375E-1
4.774E-1
 5 266
21 GO:0005938 cell cortex 2.257E-3 2.311E-2
1.375E-1
4.853E-1
 5 267
22 GO:0098644 complex of collagen trimers 2.818E-3 2.751E-2
1.637E-1
6.059E-1
 2 23
23 GO:0034774 secretory granule lumen 3.147E-3 2.751E-2
1.637E-1
6.766E-1
 3 85
24 GO:0030125 clathrin vesicle coat 3.327E-3 2.751E-2
1.637E-1
7.153E-1
 2 25
25 GO:0097489 multivesicular body, internal vesicle lumen 3.443E-3 2.751E-2
1.637E-1
7.401E-1
 1 1
26 GO:0005586 collagen type III trimer 3.443E-3 2.751E-2
1.637E-1
7.401E-1
 1 1
27 GO:0005581 collagen trimer 3.471E-3 2.751E-2
1.637E-1
7.462E-1
 3 88
28 GO:0030667 secretory granule membrane 3.583E-3 2.751E-2
1.637E-1
7.704E-1
 3 89
29 GO:0042611 MHC protein complex 3.876E-3 2.873E-2
1.710E-1
8.332E-1
 2 27
30 GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane 4.463E-3 3.017E-2
1.795E-1
9.595E-1
 2 29
31 GO:0098553 lumenal side of endoplasmic reticulum membrane 4.463E-3 3.017E-2
1.795E-1
9.595E-1
 2 29
32 GO:0005769 early endosome 4.513E-3 3.017E-2
1.795E-1
9.703E-1
 5 314
33 GO:0098794 postsynapse 4.675E-3 3.017E-2
1.795E-1
1.000E0
 6 454
34 GO:0030131 clathrin adaptor complex 4.771E-3 3.017E-2
1.795E-1
1.000E0
 2 30
35 GO:0099568 cytoplasmic region 5.282E-3 3.245E-2
1.931E-1
1.000E0
 5 326
36 GO:0060205 cytoplasmic vesicle lumen 5.539E-3 3.308E-2
1.968E-1
1.000E0
 3 104
37 GO:0098576 lumenal side of membrane 5.753E-3 3.343E-2
1.989E-1
1.000E0
 2 33
38 GO:0070435 Shc-EGFR complex 6.873E-3 3.694E-2
2.198E-1
1.000E0
 1 2
39 GO:0005584 collagen type I trimer 6.873E-3 3.694E-2
2.198E-1
1.000E0
 1 2
40 GO:0031673 H zone 6.873E-3 3.694E-2
2.198E-1
1.000E0
 1 2
41 GO:0030135 coated vesicle 9.550E-3 4.708E-2
2.802E-1
1.000E0
 4 241
42 GO:0009925 basal plasma membrane 9.624E-3 4.708E-2
2.802E-1
1.000E0
 2 43
43 GO:0005899 insulin receptor complex 1.029E-2 4.708E-2
2.802E-1
1.000E0
 1 3
44 GO:0042585 germinal vesicle 1.029E-2 4.708E-2
2.802E-1
1.000E0
 1 3
45 GO:0060053 neurofilament cytoskeleton 1.029E-2 4.708E-2
2.802E-1
1.000E0
 1 3
46 GO:0044307 dendritic branch 1.029E-2 4.708E-2
2.802E-1
1.000E0
 1 3
47 GO:0097487 multivesicular body, internal vesicle 1.029E-2 4.708E-2
2.802E-1
1.000E0
 1 3
48 GO:0030119 AP-type membrane coat adaptor complex 1.096E-2 4.829E-2
2.873E-1
1.000E0
 2 46
49 GO:0005925 focal adhesion 1.135E-2 4.829E-2
2.873E-1
1.000E0
 5 393
50 GO:0030120 vesicle coat 1.189E-2 4.829E-2
2.873E-1
1.000E0
 2 48
Show 45 more annotations

4: Human Phenotype [Display Chart] 394 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0004474 Persistent open anterior fontanelle 5.263E-5 1.303E-2
8.539E-2
 2.074E-2 2 3
2 HP:0000977 Soft skin {has synonym type="layperson"} 9.919E-5 1.303E-2
8.539E-2
 3.908E-2 3 22
3 HP:0002659 Increased susceptibility to fractures {has synonym type="layperson"} 9.919E-5 1.303E-2
8.539E-2
 3.908E-2 3 22
4 HP:0003304 Spondylolysis 1.745E-4 1.719E-2
1.127E-1
6.877E-2
 2 5
5 HP:0002645 Wormian bones 2.309E-4 1.820E-2
1.193E-1
9.098E-2
 3 29
6 HP:0000696 Delayed eruption of permanent teeth {has synonym type="layperson"} 4.850E-4 3.063E-2
2.008E-1
1.911E-1
 2 8
7 HP:0011069 Increased number of teeth {has synonym type="layperson"} 6.219E-4 3.063E-2
2.008E-1
2.450E-1
 2 9
8 HP:0000680 Delayed eruption of primary teeth 6.219E-4 3.063E-2
2.008E-1
2.450E-1
 2 9
9 HP:0002688 Absent frontal sinuses 7.754E-4 3.237E-2
2.122E-1
3.055E-1
 2 10
10 HP:0002007 Frontal bossing 8.216E-4 3.237E-2
2.122E-1
3.237E-1
 5 182
11 HP:0003302 Spondylolisthesis 1.131E-3 4.052E-2
2.656E-1
4.458E-1
 2 12
12 HP:0000347 Micrognathia 1.400E-3 4.597E-2
3.013E-1
5.517E-1
 6 309
13 HP:0001373 Joint dislocation {has synonym type="layperson"} 1.552E-3 4.704E-2
3.083E-1
6.115E-1
 2 14
Show 8 more annotations

5: Mouse Phenotype [Display Chart] 1994 annotations before applied cutoff / 9299 genes in category

No results to display

6: Domain [Display Chart] 492 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS00612 OSTEONECTIN 1 PROSITE 1.222E-5 2.005E-3 1.358E-2 6.014E-3 2 2
2 PS00613 OSTEONECTIN 2 PROSITE 1.222E-5 2.005E-3 1.358E-2 6.014E-3 2 2
3 IPR001999 Osteonectin CS InterPro 1.222E-5 2.005E-3 1.358E-2 6.014E-3 2 2
4 PF09289 FOLN Pfam 1.214E-4 1.195E-2
8.095E-2
5.973E-2
 2 5
5 IPR015369 Follistatin/Osteonectin EGF InterPro 1.214E-4 1.195E-2
8.095E-2
5.973E-2
 2 5
6 PF06623 MHC I C Pfam 1.817E-4 1.277E-2
8.653E-2
8.939E-2
 2 6
7 IPR010579 MHC I a C InterPro 1.817E-4 1.277E-2
8.653E-2
8.939E-2
 2 6
8 IPR019577 SPARC/Testican Ca-bd-dom InterPro 3.376E-4 1.846E-2
1.251E-1
1.661E-1
 2 8
9 PF10591 SPARC Ca bdg Pfam 3.376E-4 1.846E-2
1.251E-1
1.661E-1
 2 8
10 PD002078 Fib collagen C ProDom 6.586E-4 2.025E-2
1.372E-1
3.240E-1
 2 11
11 IPR000885 Fib collagen C InterPro 6.586E-4 2.025E-2
1.372E-1
3.240E-1
 2 11
12 PF01410 COLFI Pfam 6.586E-4 2.025E-2
1.372E-1
3.240E-1
 2 11
13 IPR003645 Fol N InterPro 6.586E-4 2.025E-2
1.372E-1
3.240E-1
 2 11
14 SM00038 COLFI SMART 6.586E-4 2.025E-2
1.372E-1
3.240E-1
 2 11
15 SM00274 FOLN SMART 6.586E-4 2.025E-2
1.372E-1
3.240E-1
 2 11
16 PS51461 NC1 FIB PROSITE 6.586E-4 2.025E-2
1.372E-1
3.240E-1
 2 11
17 IPR003112 Olfac-like dom InterPro 9.298E-4 2.287E-2
1.550E-1
4.575E-1
 2 13
18 SM00284 OLF SMART 9.298E-4 2.287E-2
1.550E-1
4.575E-1
 2 13
19 PS51132 OLF PROSITE 9.298E-4 2.287E-2
1.550E-1
4.575E-1
 2 13
20 PF02191 OLF Pfam 9.298E-4 2.287E-2
1.550E-1
4.575E-1
 2 13
21 PF00092 VWA Pfam 1.013E-3 2.373E-2
1.608E-1
4.984E-1
 3 56
22 3.40.50.410 - Gene3D 2.264E-3 3.270E-2
2.216E-1
1.000E0
 3 74
23 PF00129 MHC I Pfam 2.458E-3 3.270E-2
2.216E-1
1.000E0
 2 21
24 IPR001039 MHC I a a1/a2 InterPro 2.458E-3 3.270E-2
2.216E-1
1.000E0
 2 21
25 PF00050 Kazal 1 Pfam 2.698E-3 3.270E-2
2.216E-1
1.000E0
 2 22
26 SM00210 TSPN SMART 2.948E-3 3.270E-2
2.216E-1
1.000E0
 2 23
27 PS50234 VWFA PROSITE 3.032E-3 3.270E-2
2.216E-1
1.000E0
 3 82
28 3.30.500.10 - Gene3D 3.209E-3 3.270E-2
2.216E-1
1.000E0
 2 24
29 IPR011161 MHC I-like Ag-recog InterPro 3.209E-3 3.270E-2
2.216E-1
1.000E0
 2 24
30 SM00327 VWA SMART 3.246E-3 3.270E-2
2.216E-1
1.000E0
 3 84
31 IPR008160 Collagen InterPro 3.357E-3 3.270E-2
2.216E-1
1.000E0
 3 85
32 PF01391 Collagen Pfam 3.357E-3 3.270E-2
2.216E-1
1.000E0
 3 85
33 IPR018247 EF Hand 1 Ca BS InterPro 3.379E-3 3.270E-2
2.216E-1
1.000E0
 4 175
34 PF16045 LisH 2 Pfam 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
35 IPR015644 Peptidase C1A cathepsin-K InterPro 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
36 IPR026145 IL-33 InterPro 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
37 IPR028540 AKAP12 InterPro 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
38 IPR008122 TF AP2 beta InterPro 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
39 PF15095 IL33 Pfam 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
40 IPR000277 Cys/Met-Metab PyrdxlP-dep enz InterPro 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
41 IPR031216 Noelin-3 InterPro 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
42 IPR033197 DDAH1 InterPro 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
43 IPR016359 SPARC-like p1 InterPro 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
44 IPR030709 Protocadherin-17 InterPro 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
45 PF01053 Cys Met Meta PP Pfam 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
46 IPR026102 Odf2-like InterPro 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
47 IPR031230 OLFML3 InterPro 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
48 IPR030179 PLTP InterPro 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
49 IPR029926 Dystonin InterPro 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
50 IPR022341 IGF-I InterPro 3.523E-3 3.270E-2
2.216E-1
1.000E0
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 479 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 523016 Transcriptional misregulation in cancer BioSystems: KEGG 1.362E-5 4.814E-3 3.249E-2 6.524E-3 7 179
2 576262 Extracellular matrix organization BioSystems: REACTOME 2.010E-5 4.814E-3 3.249E-2 9.628E-3 8 264
3 M5884 Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans MSigDB C2 BIOCARTA (v5.1) 2.071E-4 3.165E-2
2.136E-1
9.922E-2
 7 275
4 198807 Alpha6-Beta4 Integrin Signaling Pathway BioSystems: WikiPathways 2.643E-4 3.165E-2
2.136E-1
1.266E-1
 4 70

8: Pubmed [Display Chart] 21447 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19453261:gr High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. GeneRIF 3.674E-8 3.422E-4 3.610E-3 7.879E-4 8 383
2 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 3.674E-8 3.422E-4 3.610E-3 7.879E-4 8 383
3 9686604 Sequence-based typing provides a new look at HLA-C diversity. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
4 26613595 An HLA-C amino-acid variant in addition to HLA-B*27 confers risk for ankylosing spondylitis in the Korean population. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
5 16970944 Transactivation of epidermal growth factor receptor by insulin-like growth factor 1 requires basal hydrogen peroxide. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
6 16439971 Distinct clinical differences between HLA-Cw*0602 positive and negative psoriasis patients--an analysis of 1019 HLA-C- and HLA-B-typed patients. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
7 16439971:gr Distinct clinical differences between HLA-Cw*0602 positive and negative psoriasis patients--an analysis of 1019 HLA-C- and HLA-B-typed patients. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
8 23536655:gr Epstein-Barr virus negativity among individuals older than 60 years is associated with HLA-C and HLA-Bw4 variants and tonsillectomy. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
9 22586163 Differential human leucocyte allele association between psoriasis and psoriatic arthritis: a family-based association study. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
10 15603879:gr The contribution of HLA class I antigens in immune status following two doses of rubella vaccination. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
11 21424113:gr Postprandial activation of protein kinase Cµ regulates the expression of adipocytokines via the transcription factor AP-2�. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
12 14626512 Distribution of the HLA class I allele in chronic hepatitis C and its association with serum ALT level in chronic hepatitis C. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
13 3485286 Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
14 17085834 HLA alleles in pre-menopausal breast cancer patients from western India. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
15 14501803 Association of HLA B*3520, B*1801, and Cw*1507 with HIV-1 infection Maharashtra, India. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
16 21985130 HLA polymorphism among Chinese patients with chronic plaque psoriasis: subgroup analysis. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
17 20097161:gr Transcription factor AP-2beta: a negative regulator of IRS-1 gene expression. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
18 22173850:gr SPARC-like 1 (SC1) is a diversely expressed and developmentally regulated matricellular protein that does not compensate for the absence of SPARC in the CNS. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
19 23462218 MHC-driven HIV-1 control on the long run is not systematically determined at early times post-HIV-1 infection. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
20 18724390:gr Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
21 9234488 The novel HLA-Cw*1802 allele is associated with B*5703 in the Bubi population from Equatorial Guinea. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
22 17480220 Associations between HLA class I alleles and the prevalence of nasopharyngeal carcinoma (NPC) among Tunisians. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
23 10395103 Diversity of HLA-B17 alleles and haplotypes in East Asians and a novel Cw6 allele (Cw*0604) associated with B*5701. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
24 21832070:gr Recycling of the epidermal growth factor receptor is mediated by a novel form of the clathrin adaptor protein Eps15. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
25 18329312:gr Distribution of HLA-B*27 subtypes in Tunisians and their association with ankylosing spondylitis. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
26 22359227:gr Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
27 19898503 Effect of missing killer-immunoglobulin-like receptor ligand in recipients undergoing HLA full matched, non-T-depleted sibling donor transplantation: a single institution experience of 151 Asian patients. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
28 19639489 Subcellular localization of IRS-1 in IGF-I-mediated chondrogenic proliferation, differentiation and hypertrophy of bone marrow mesenchymal stem cells. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
29 20220555:gr Regulation of human adipose-derived stromal cell osteogenic differentiation by insulin-like growth factor-1 and platelet-derived growth factor-alpha. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
30 9089103 Differences in intron 2 sequences between B*39061 and B*39062 in Amerindians: comparison with those of B*3901, B*5101, and B*52012 alleles. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
31 12202493:gr Nuclear translocation of insulin receptor substrate-1 by oncogenes and Igf-I. Effect on ribosomal RNA synthesis. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
32 21051598:gr The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
33 19639489:gr Subcellular localization of IRS-1 in IGF-I-mediated chondrogenic proliferation, differentiation and hypertrophy of bone marrow mesenchymal stem cells. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
34 20604894 Comparison of MHC class I risk haplotypes in Thai and Caucasian psoriatics shows locus heterogeneity at PSORS1. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
35 17641165 A whole-genome association study of major determinants for host control of HIV-1. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
36 17597093:gr A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
37 15304489:gr Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathway. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
38 8647860 Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
39 10885573 Identification of a novel HLA-Cw*05 allele, Cw*0503. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
40 18702622 Combined effects of HLA-Cw6 and cigarette smoking in psoriasis vulgaris: a hospital-based case-control study in China. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
41 20604894:gr Comparison of MHC class I risk haplotypes in Thai and Caucasian psoriatics shows locus heterogeneity at PSORS1. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
42 26068923 Protective Effect of HLA-B*5701 and HLA-C -35 Genetic Variants in HIV-Positive Caucasians from Northern Poland. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
43 21788491:gr Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
44 14626512:gr Distribution of the HLA class I allele in chronic hepatitis C and its association with serum ALT level in chronic hepatitis C. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
45 25670150 Nicotine induces resistance to erlotinib via cross-talk between ¿ 1 nAChR and EGFR in the non-small cell lung cancer xenograft model. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
46 21585707 Analysis for complete genomic sequence of HLA-B and HLA-C alleles in the Chinese Han population. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
47 23536655 Epstein-Barr virus negativity among individuals older than 60 years is associated with HLA-C and HLA-Bw4 variants and tonsillectomy. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
48 18596105 Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
49 15191523:gr HLA-B and HLA-C alleles and haplotypes in the Dravidian tribal populations of southern India. GeneRIF 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
50 7871529 HLA class I alleles of LCL 721 and 174 x CEM.T2 (T2). Pubmed 1.645E-6 3.422E-4 3.610E-3 3.527E-2 2 2
Show 45 more annotations

9: Interaction [Display Chart] 2415 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:SPARC SPARC interactions 4.014E-8 9.693E-5 8.110E-4 9.693E-5 5 25
2 int:PDGFA PDGFA interactions 3.821E-7 4.613E-4 3.860E-3 9.227E-4 4 16
3 int:MYOC MYOC interactions 3.135E-5 2.524E-2
2.112E-1
7.572E-2
 4 46
4 int:B4GALNT1 B4GALNT1 interactions 4.554E-5 2.749E-2
2.300E-1
1.100E-1
 2 3
5 int:NEK4 NEK4 interactions 6.302E-5 2.921E-2
2.444E-1
1.522E-1
 3 20
6 int:COL3A1 COL3A1 interactions 7.332E-5 2.921E-2
2.444E-1
1.771E-1
 3 21
7 int:PDGFB PDGFB interactions 8.466E-5 2.921E-2
2.444E-1
2.045E-1
 3 22
8 int:LDB2 LDB2 interactions 1.106E-4 3.340E-2
2.795E-1
2.672E-1
 3 24
9 int:SPARCL1 SPARCL1 interactions 1.510E-4 3.481E-2
2.913E-1
3.647E-1
 2 5
10 int:HLA-H HLA-H interactions 1.510E-4 3.481E-2
2.913E-1
3.647E-1
 2 5
11 int:AKAP12 AKAP12 interactions 1.586E-4 3.481E-2
2.913E-1
3.829E-1
 3 27
12 int:HDAC7 HDAC7 interactions 1.932E-4 3.887E-2
3.252E-1
4.665E-1
 4 73
13 int:HLA-A HLA-A interactions 2.144E-4 3.983E-2
3.333E-1
5.178E-1
 4 75
14 int:CTTNBP2NL CTTNBP2NL interactions 2.409E-4 4.156E-2
3.478E-1
5.819E-1
 3 31
15 int:PCK1 PCK1 interactions 2.620E-4 4.218E-2
3.529E-1
6.327E-1
 4 79
16 int:SSBP2 SSBP2 interactions 2.908E-4 4.390E-2
3.673E-1
7.023E-1
 3 33
17 int:NCAPH2 NCAPH2 interactions 3.181E-4 4.519E-2
3.781E-1
7.681E-1
 3 34
Show 12 more annotations

10: Cytoband [Display Chart] 60 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1p22 1p22 7.686E-6 3.309E-4 1.548E-3 4.612E-4 3 20
2 7p12 7p12 1.103E-5 3.309E-4 1.548E-3 6.617E-4 2 3
3 1p22.3 1p22.3 8.293E-4 1.659E-2
7.762E-2
 4.976E-2 2 22
4 1p32 1p32 1.252E-3 1.878E-2
8.791E-2
7.514E-2
 2 27
5 8p11.2-p11.1 8p11.2-p11.1 3.862E-3 2.575E-2
1.205E-1
2.317E-1
 1 2
6 6p12.3-p11.2 6p12.3-p11.2 3.862E-3 2.575E-2
1.205E-1
2.317E-1
 1 2
7 22q11.2-q12.1 22q11.2-q12.1 3.862E-3 2.575E-2
1.205E-1
2.317E-1
 1 2
8 5q31.3-q32 5q31.3-q32 3.862E-3 2.575E-2
1.205E-1
2.317E-1
 1 2
9 6q22.2 6q22.2 3.862E-3 2.575E-2
1.205E-1
2.317E-1
 1 2
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 417 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 40 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1278 SPARC family genenames.org 1.375E-4 3.015E-3 1.290E-2 5.502E-3 2 8
2 490 Collagens genenames.org 1.507E-4 3.015E-3 1.290E-2 6.030E-3 3 46
3 591 C1-set domain containing genenames.org 4.029E-3 4.415E-2
1.889E-1
1.612E-1
 2 42
4 588 Histocompatibility complex|C1-set domain containing genenames.org 4.415E-3 4.415E-2
1.889E-1
1.766E-1
 2 44
5 1218 LIM domain containing genenames.org 7.816E-3 4.482E-2
1.918E-1
3.126E-1
 2 59
6 1096 Erb-b2 receptor tyrosine kinases genenames.org 8.984E-3 4.482E-2
1.918E-1
3.594E-1
 1 4
7 867 Chloride channel accessory genenames.org 8.984E-3 4.482E-2
1.918E-1
3.594E-1
 1 4
8 461 Carboxylesterases genenames.org 1.122E-2 4.482E-2
1.918E-1
4.487E-1
 1 5
9 1217 Brain expressed X-linked family genenames.org 1.122E-2 4.482E-2
1.918E-1
4.487E-1
 1 5
10 525 SINE class homeoboxes genenames.org 1.345E-2 4.482E-2
1.918E-1
5.379E-1
 1 6
11 699 Protein phosphatase 6 regulatory subunits genenames.org 1.345E-2 4.482E-2
1.918E-1
5.379E-1
 1 6
12 1165 Basic leucine zipper proteins|CCAAT/enhancer binding proteins genenames.org 1.345E-2 4.482E-2
1.918E-1
5.379E-1
 1 6
Show 7 more annotations

13: Coexpression [Display Chart] 4354 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.423E-13 6.194E-10 5.547E-9 6.194E-10 16 425
2 M15981 Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.713E-12 5.906E-9 5.289E-8 1.181E-8 15 430
3 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.880E-10 5.631E-7 5.043E-6 1.689E-6 11 260
4 M12225 Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.557E-10 7.137E-7 6.392E-6 2.855E-6 10 205
5 M7514 Genes down-regulated in NIH3T3 cells (fibroblasts) transformed by expression of contitutively active (Q63L) form of RHOA [GeneID=387] off plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.434E-9 2.120E-6 1.898E-5 1.060E-5 12 394
6 M13867 Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.601E-9 4.065E-6 3.640E-5 2.439E-5 10 256
7 M7396 Genes down-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.369E-9 4.583E-6 4.105E-5 3.208E-5 12 435
8 M13206 Genes down-regulated in TC71 and EWS502 cells (Ewing's sarcoma) by EWSR1-FLI1 [GeneID=2130;2314] as inferred from RNAi knockdown of this fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.524E-8 3.006E-5 2.693E-4 2.405E-4 10 326
9 M2698 Genes up-regulated in NCI-60 panel of cell lines with mutated TP53 [Gene ID=7157]. MSigDB C6: Oncogenic Signatures (v5.1) 1.385E-7 6.699E-5 5.999E-4 6.029E-4 8 194
10 M4995 Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.913E-7 1.268E-4 1.136E-3 1.268E-3 10 390
11 M12300 Up-regulated genesin the left ventricle myocardium of patients with heart failure following implantation of LVAD (left ventricular assist device). MSigDB C2: CGP Curated Gene Sets (v5.1) 7.455E-7 2.951E-4 2.643E-3 3.246E-3 6 103
12 M5505 Genes down-regulated in basal mammary epithelial cells compared to the luminal ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.022E-6 3.708E-4 3.321E-3 4.449E-3 5 59
13 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.307E-6 4.377E-4 3.920E-3 5.689E-3 10 460
14 M2670 Genes down-regulated by everolimus [PubChem = 6442177] in prostate tissue. MSigDB C6: Oncogenic Signatures (v5.1) 1.513E-6 4.707E-4 4.215E-3 6.589E-3 7 184
15 M2905 Genes up-regulated in DLD1 cells (colon carcinoma) over-expressing LEF1 [Gene ID=51176]. MSigDB C6: Oncogenic Signatures (v5.1) 2.228E-6 6.466E-4 5.791E-3 9.699E-3 7 195
16 GSE26488 CTRL VS PEPTIDE INJECTION HDAC7 DELTAP TG OT2 THYMOCYTE UP Genes up-regulated in double positive thymocyte from OT-2 transgenic mice: control versus HDAC7 [GeneID=51564] deltaP form after injection with agonist peptide. MSigDB C7: Immunologic Signatures (v5.1) 2.635E-6 6.749E-4 6.044E-3 1.147E-2 7 200
17 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v5.1) 2.635E-6 6.749E-4 6.044E-3 1.147E-2 7 200
18 M13251 Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 14 h time point that were not down-regulated at the previous time point, 12 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.432E-6 7.864E-4 7.043E-3 1.494E-2 8 297
19 M2581 Genes up-regulated in the HSC supportive stromal cell lines. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.432E-6 7.864E-4 7.043E-3 1.494E-2 8 297
20 M1561 Genes down-regulated in BJ cells (foreskin fibroblasts) immortalized by expression of TERT [GeneID=7015]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.669E-6 1.017E-3 9.104E-3 2.033E-2 5 80
21 M2259 Partial list of genes up-regulated in the kidney of GLIS2 [GeneID=84662] knockout mice compared to the wild type. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.940E-6 1.201E-3 1.076E-2 2.586E-2 5 84
22 M2256 Genes commonly down-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313 ,2078]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.069E-6 1.201E-3 1.076E-2 2.642E-2 7 227
23 M1484 Genes up-regulated in pancreatic cells from mice with double knockout of E2F1 [GeneID=1869] and E2F2 [GeneID=1870] compared to wild type. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.921E-6 1.270E-3 1.137E-2 3.014E-2 6 151
24 M13273 Genes down-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.998E-6 1.270E-3 1.137E-2 3.047E-2 7 232
25 M17471 Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS, non-invasive). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.164E-5 2.027E-3 1.815E-2
5.066E-2
 8 351
26 M4680 Genes up-regulated in RD cells (embryonal rhabdomyosarcoma, ERMS) by expression of PAX3- or PAX7-FOXO1 [GeneID=5077;5081;2308] fusions off retroviral vectors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.294E-5 2.167E-3 1.941E-2
5.634E-2
 7 255
27 M15669 Top 50 most up-regulated genes in human platelet cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.415E-5 2.282E-3 2.043E-2
6.160E-2
 4 48
28 M19391 Genes down-regulated in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.518E-5 2.360E-3 2.114E-2
6.608E-2
 9 480
29 M5389 Genes whose expression increases with age in normal kidney. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.674E-5 2.514E-3 2.251E-2
7.290E-2
 9 486
30 M8519 Genes down-regulated in mARMS (molecular ARMS) compared to the mERMS (molecular ERMS) class of rhabdomyosarcoma tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.005E-5 2.910E-3 2.606E-2
8.729E-2
 6 182
31 M9483 Genes up-regulated in metastatic vs non-metastatic stromal cells originated from either bone or prostate tissues. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.215E-5 3.111E-3 2.786E-2
9.643E-2
 5 110
32 M2871 YAP conserved signature. MSigDB C6: Oncogenic Signatures (v5.1) 2.813E-5 3.663E-3 3.281E-2
1.225E-1
 4 57
33 M2379 Genes up-regulated in hypertrophic hearts (due to expression of constitutively active form of PPP3CA [GeneID=5530]) and predicted to be targets of miR-30 microRNA. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.862E-5 3.663E-3 3.281E-2
1.246E-1
 5 116
34 M11616 Genes whose promoters display higher levels of histone H3 trimethylation mark at K27 (H3K27me3) in hepatocellular carcinoma (HCC) compared to normal liver. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.157E-5 3.663E-3 3.281E-2
1.375E-1
 7 293
35 M5295 Genes up-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from old donors versus those treated with TSST at 16 h. MSigDB C7: Immunologic Signatures (v5.1) 3.313E-5 3.663E-3 3.281E-2
1.443E-1
 6 199
36 M4366 Genes up-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from wild type mice subjected to ozone for 24 h. MSigDB C7: Immunologic Signatures (v5.1) 3.408E-5 3.663E-3 3.281E-2
1.484E-1
 6 200
37 M5909 Genes involved in development of skeletal muscle (myogenesis). MSigDB H: Hallmark Gene Sets (v5.1) 3.408E-5 3.663E-3 3.281E-2
1.484E-1
 6 200
38 M6802 Genes down-regulated in T conv versus T reg FOXP3 [GeneID=50943] knockout. MSigDB C7: Immunologic Signatures (v5.1) 3.408E-5 3.663E-3 3.281E-2
1.484E-1
 6 200
39 GSE34156 NOD2 LIGAND VS TLR1 TLR2 LIGAND 6H TREATED MONOCYTE UP Genes up-regulated in monocytes (6h): muramyl dipeptide [PubChem=11620162] versus M. tuberculosis 19 kDa lipopeptide. MSigDB C7: Immunologic Signatures (v5.1) 3.408E-5 3.663E-3 3.281E-2
1.484E-1
 6 200
40 GSE26912 TUMORICIDAL VS CTRL MACROPHAGE UP Genes up-regulated in macrophages: tumoricidal versus control. MSigDB C7: Immunologic Signatures (v5.1) 3.408E-5 3.663E-3 3.281E-2
1.484E-1
 6 200
41 M5929 Genes up-regulated in ANBL-6 cell line (multiple myeloma, MM) co-cultured with bone marrow stromal cells compared to those grown in the presence of IL6 [GeneID=3569]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.449E-5 3.663E-3 3.281E-2
1.502E-1
 4 60
42 M178 Tumorigenesis markers of head and neck squamous cell carcinoma (HNSCC): up-regulated in the 'early' tumors vs normal samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.184E-5 4.338E-3 3.885E-2
1.822E-1
 4 63
43 M2572 Genes in the 'mesenchymal transition signature' common to all invasive cancer types. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.453E-5 4.509E-3 4.038E-2
1.939E-1
 4 64
44 M2024 Genes up-regulated in mesenchymal stem cells during early phase of adipogenesis, defined as days 1 to 5 of culturing with adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.734E-5 4.685E-3 4.196E-2
2.061E-1
 4 65
45 M8582 Genes down-regulated in peripheral blood monocytes by CSF2RB (GM-CSF) and IL4 [GeneID=1437;3565]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.897E-5 4.729E-3 4.235E-2
2.132E-1
 7 314
46 M15107 Genes up-regulated in CD133+ [GeneID=8842] cells (hematopoietic stem cells, HSC) compared to the CD133- cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.996E-5 4.729E-3 4.235E-2
2.175E-1
 7 315
47 M4665 Genes down-regulated in glomeruli of kidneys from patients with diabetic nephropathy (type 2 diabetes mellitus). MSigDB C2: CGP Curated Gene Sets (v5.1) 5.286E-5 4.897E-3 4.386E-2
2.302E-1
 8 434
48 M13907 Down-regulated in brown preadipocytes with IRS1 [GeneID=3667] knockout vs wild type controls; the knockouts have severe defects in adipocyte differentiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.915E-5 5.216E-3 4.671E-2
2.575E-1
 5 135
49 M9893 Genes whose expression increases with age in normal kidney, excluding those with higher expression in blood. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.943E-5 5.216E-3 4.671E-2
2.588E-1
 6 221
50 M10165 Genes up-regulated in lobular carcinoma vs normal ductal breast cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.990E-5 5.216E-3 4.671E-2
2.608E-1
 4 69
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2425 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 5.009E-12 1.215E-8 1.017E-7 1.215E-8 15 438
2 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 8.657E-11 7.051E-8 5.903E-7 2.099E-7 14 445
3 gudmap dev gonad e13.5 M InterstitTestis Sma 500 dev gonad e13.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.723E-11 7.051E-8 5.903E-7 2.115E-7 13 362
4 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma 500 dev gonad e13.5 F VascAssocMesenchStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.262E-10 7.653E-8 6.406E-7 3.061E-7 13 373
5 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 3.845E-9 1.865E-6 1.561E-5 9.324E-6 13 494
6 gudmap dev gonad e13.5 M InterstitFLeydig MafB k3 200 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 6.953E-9 2.570E-6 2.151E-5 1.686E-5 7 82
7 gudmap dev gonad e13.5 M InterstitFLeydig MafB k3 1000 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 7.417E-9 2.570E-6 2.151E-5 1.799E-5 11 336
8 gudmap dev gonad e13.5 M InterstitFLeydig MafB 500 dev gonad e13.5 M InterstitFLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.347E-8 3.534E-6 2.959E-5 3.267E-5 11 356
9 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB 500 dev gonad e13.5 F VascAssocMesenchStromOvary MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.427E-8 3.534E-6 2.959E-5 3.461E-5 11 358
10 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 1.527E-8 3.534E-6 2.959E-5 3.703E-5 12 453
11 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 1.603E-8 3.534E-6 2.959E-5 3.888E-5 12 455
12 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 2.137E-8 4.224E-6 3.536E-5 5.181E-5 12 467
13 GSM777043 100 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 2.264E-8 4.224E-6 3.536E-5 5.491E-5 7 97
14 gudmap developingKidney e14.5 whole kidney - Wnt4 KO 500 DevelopingKidney e14.5 whole kidney - Wnt4 KO emap-6674 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.255E-8 5.637E-6 4.719E-5 7.892E-5 11 388
15 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 3.874E-8 6.263E-6 5.242E-5 9.394E-5 12 493
16 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 4.140E-8 6.274E-6 5.252E-5 1.004E-4 12 496
17 gudmap dev gonad e13.5 M InterstitFLeydig MafB k4 500 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.030E-7 1.469E-5 1.230E-4 2.498E-4 8 182
18 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB k2 1000 dev gonad e13.5 F VascAssocMesenchStromOvary MafB k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.460E-7 1.906E-5 1.596E-4 3.541E-4 9 266
19 gudmap dev gonad e12.5 M InterstitTestis Sma k4 1000 dev gonad e12.5 M InterstitTestis Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.493E-7 1.906E-5 1.596E-4 3.622E-4 8 191
20 Lungmap Mouse e16.5 Epithelial SubClass Proliferative AT1 Progenitor Top 500 Cluster 4 Mouse Lung E16.5 Epithelial Proliferative AT1 Progenitor c4 Lungmap Mouse Single Cell (Lungmap.net) 2.063E-7 2.502E-5 2.094E-4 5.004E-4 4 17
21 gudmap dev gonad e12.5 M InterstitTestis Sma 500 dev gonad e12.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.503E-7 2.890E-5 2.419E-4 6.070E-4 10 374
22 GSM777050 100 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 3.183E-7 3.509E-5 2.937E-4 7.719E-4 6 87
23 gudmap dev gonad e12.5 F VasAssocMesStromOvary Sma 500 dev gonad e12.5 F VasAssocMesStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.346E-7 3.528E-5 2.953E-4 8.113E-4 10 386
24 endothelial SubClass DCN-hi Top 500 All endothelial SubClass DCN-hi Top 500 All Brain Map - Barres 3.770E-7 3.673E-5 3.075E-4 9.143E-4 11 495
25 gudmap dev gonad e13.5 M InterstitFLeydig MafB 200 dev gonad e13.5 M InterstitFLeydig MafB top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 3.787E-7 3.673E-5 3.075E-4 9.184E-4 7 146
26 gudmap dev gonad e13.5 M InterstitTestis Sma k1 500 dev gonad e13.5 M InterstitTestis Sma k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 5.931E-7 5.532E-5 4.631E-4 1.438E-3 7 156
27 endothelial SubClass DCN-hi Top 500 Cluster 1 endothelial SubClass DCN-hi Top 500 Cluster 1 Brain Map - Barres 6.568E-7 5.899E-5 4.938E-4 1.593E-3 8 232
28 PCBC ratio MESO-5 amniotic fluid MSC vs MESO-5 blastocyst cfr-2X-p05 MESO-5 amniotic fluid MSC vs MESO-5 blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 7.878E-7 6.823E-5 5.711E-4 1.910E-3 10 424
29 gudmap dev gonad e12.5 F VasAssMesen MafB k3 1000 dev gonad e12.5 F VasAssMesen MafB k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.085E-6 9.070E-5 7.592E-4 2.630E-3 6 107
30 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 1.675E-6 1.354E-4 1.134E-3 4.063E-3 10 461
31 JC fibro 1000 K1 JC fibro top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 1.776E-6 1.389E-4 1.163E-3 4.306E-3 10 464
32 gudmap dev gonad e13.5 F gudmap devVascOvary Flk k2 500 dev gonad e13.5 F DevVascOvary Flk k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.038E-6 1.544E-4 1.293E-3 4.941E-3 5 66
33 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB k3 500 dev gonad e13.5 F VascAssocMesenchStromOvary MafB k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.452E-6 1.802E-4 1.508E-3 5.946E-3 6 123
34 astrocytes Top 500 All astrocytes Top 500 All Brain Map - Barres 3.218E-6 2.279E-4 1.907E-3 7.804E-3 10 496
35 gudmap developingKidney e14.5 whole kidney - Wnt4 KO 1000 k5 DevelopingKidney e14.5 whole kidney - Wnt4 KO emap-6674 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.304E-6 2.279E-4 1.907E-3 8.012E-3 8 288
36 gudmap dev gonad e12.5 M InterstitTestis Sma k2 500 dev gonad e12.5 M InterstitTestis Sma k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.383E-6 2.279E-4 1.907E-3 8.203E-3 6 130
37 Facebase ST1 e11.5 Emin MedNasl SingCel 250 e11.5 Emin MedNasl SingCel top-relative-expression-ranked 250 FaceBase_ST1 3.676E-6 2.402E-4 2.010E-3 8.914E-3 7 205
38 PCBC ratio ECTO blastocyst vs ECTO UCB CD34+Z cfr-2X-p05 ECTO blastocyst vs ECTO UCB CD34+Z-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 3.847E-6 2.402E-4 2.010E-3 9.329E-3 8 294
39 astrocytes Top 500 Cluster 3 astrocytes Top 500 Cluster 3 Brain Map - Barres 3.862E-6 2.402E-4 2.010E-3 9.366E-3 4 34
40 PCBC ratio DE vs MESO-5 cfr-2X-p05 Endoderm Differentiated Cells vs Mesoderm Day 5-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 4.046E-6 2.453E-4 2.053E-3 9.811E-3 7 208
41 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.279E-6 3.122E-4 2.614E-3 1.280E-2 9 410
42 gudmap developingKidney e14.5 whole kidney - Wnt4 KO 1000 k2 DevelopingKidney e14.5 whole kidney - Wnt4 KO emap-6674 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.635E-6 3.254E-4 2.724E-3 1.367E-2 6 142
43 gudmap dev gonad e12.5 M InterstitLeydig MafB k1 1000 dev gonad e12.5 M InterstitLeydig MafB k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 5.814E-6 3.279E-4 2.745E-3 1.410E-2 8 311
44 gudmap dev gonad e11.5 M GonadVasMes Flk 500 dev gonad e11.5 M GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.289E-6 3.466E-4 2.902E-3 1.525E-2 9 419
45 GSM777067 100 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 7.142E-6 3.762E-4 3.150E-3 1.732E-2 5 85
46 Facebase ST1 e11.5 Emin MedNasl SingCel 100 e11.5 Emin MedNasl SingCel top-relative-expression-ranked 100 FaceBase_ST1 7.142E-6 3.762E-4 3.150E-3 1.732E-2 5 85
47 OPC Top 500 Cluster 1 OPC Top 500 Cluster 1 Brain Map - Barres 7.504E-6 3.762E-4 3.150E-3 1.820E-2 4 40
48 gudmap developingLowerUrinaryTract e14.5 Genital tubercle F 500 DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.602E-6 3.762E-4 3.150E-3 1.844E-2 9 429
49 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 500 DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.602E-6 3.762E-4 3.150E-3 1.844E-2 9 429
50 80Dn Top 500 Cluster 2 80Dn Top 500 Cluster 2 Brain Map - Allen iN 8.047E-6 3.903E-4 3.267E-3 1.951E-2 7 231
Show 45 more annotations

15: Computational [Display Chart] 218 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 4.116E-6 8.972E-4 5.351E-3 8.972E-4 11 361
2 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 2.487E-5 2.711E-3 1.617E-2 5.423E-3 8 216
3 module 6 Genes in module 6 MSigDb: C4 - CM: Cancer Modules 7.603E-5 5.525E-3 3.295E-2 1.657E-2 10 407
4 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 5.282E-4 2.662E-2
1.588E-1
1.151E-1
 9 423
5 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 7.112E-4 2.662E-2
1.588E-1
1.550E-1
 8 351
6 module 513 Genes in module 513 MSigDb: C4 - CM: Cancer Modules 8.548E-4 2.662E-2
1.588E-1
1.864E-1
 2 8
7 module 144 Genes in module 144 MSigDb: C4 - CM: Cancer Modules 8.548E-4 2.662E-2
1.588E-1
1.864E-1
 2 8
8 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 1.152E-3 3.138E-2
1.872E-1
2.511E-1
 8 378
9 module 293 Genes in module 293 MSigDb: C4 - CM: Cancer Modules 1.986E-3 4.431E-2
2.643E-1
4.330E-1
 2 12
10 GNF2 HLA-C Neighborhood of HLA-C MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.033E-3 4.431E-2
2.643E-1
4.431E-1
 3 45
Show 5 more annotations

16: MicroRNA [Display Chart] 934 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-29c:miRTarbase hsa-miR-29c:miRTarbase miRTarbase 3.486E-6 2.311E-3 1.714E-2 3.256E-3 4 31
2 hsa-miR-34b:PITA hsa-miR-34b:PITA TOP PITA 4.949E-6 2.311E-3 1.714E-2 4.622E-3 9 379
3 hsa-miR-29c:miRecords TarBase hsa-miR-29c:miRecords TarBase miRecords_TarBase 1.626E-5 5.062E-3 3.755E-2 1.519E-2 3 15
4 hsa-miR-410:PITA hsa-miR-410:PITA TOP PITA 3.014E-5 7.037E-3
5.220E-2
 2.815E-2 8 364
5 hsa-miR-508-5p:PITA hsa-miR-508-5p:PITA TOP PITA 5.202E-5 9.717E-3
7.207E-2
 4.858E-2 6 196
6 hsa-miR-7:miRecords TarBase hsa-miR-7:miRecords TarBase miRecords_TarBase 1.116E-4 1.598E-2
1.185E-1
1.042E-1
 2 5
7 hsa-miR-188-3p:PITA hsa-miR-188-3p:PITA TOP PITA 1.198E-4 1.598E-2
1.185E-1
1.119E-1
 6 228
Show 2 more annotations

17: Drug [Display Chart] 13359 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C011669 ascorbate-2-phosphate CTD 6.455E-10 8.623E-6 8.689E-5 8.623E-6 5 15
2 CID006918182 strontium ranelate Stitch 3.471E-9 1.823E-5 1.837E-4 4.637E-5 7 77
3 C487081 belinostat CTD 4.094E-9 1.823E-5 1.837E-4 5.470E-5 12 417
4 C070081 fulvestrant CTD 1.662E-8 5.549E-5 5.592E-4 2.220E-4 12 473
5 C446685 systhane CTD 7.429E-7 1.985E-3 2.000E-2 9.924E-3 6 104
6 CID000030956 AC1L1KMJ Stitch 1.618E-6 2.911E-3 2.933E-2 2.161E-2 10 476
7 4580 UP Beclomethasone dipropionate [5534-09-8]; Up 200; 7.6uM; PC3; HT HG-U133A Broad Institute CMAP 1.876E-6 2.911E-3 2.933E-2 2.506E-2 7 192
8 6445 DN Meglumine [6284-40-8]; Down 200; 20.4uM; MCF7; HT HG-U133A Broad Institute CMAP 2.151E-6 2.911E-3 2.933E-2 2.874E-2 7 196
9 D005960 Glucosides CTD 2.209E-6 2.911E-3 2.933E-2 2.951E-2 3 9
10 C013172 gamma-oryzanol CTD 2.209E-6 2.911E-3 2.933E-2 2.951E-2 3 9
11 C010176 halofuginone CTD 2.397E-6 2.911E-3 2.933E-2 3.202E-2 6 127
12 D015056 1-Methyl-3-isobutylxanthine CTD 2.680E-6 2.984E-3 3.007E-2 3.580E-2 9 391
13 D000537 Aluminum Oxide CTD 3.224E-6 3.313E-3 3.339E-2 4.307E-2 5 75
14 CID000161853 GK-101 Stitch 4.225E-6 3.822E-3 3.852E-2
5.645E-2
 4 36
15 C005274 naringin CTD 4.395E-6 3.822E-3 3.852E-2
5.871E-2
 6 141
16 C041711 St. Thomas' Hospital cardioplegic solution CTD 4.578E-6 3.822E-3 3.852E-2
6.116E-2
 6 142
17 C113580 U 0126 CTD 4.981E-6 3.914E-3 3.944E-2
6.654E-2
 9 422
18 D002164 Camphor CTD 5.747E-6 4.265E-3 4.298E-2
7.678E-2
 3 12
19 D019287 Zinc Sulfate CTD 9.957E-6 7.001E-3
7.055E-2
1.330E-1
 9 460
20 CID000108062 Madecassol Stitch 1.144E-5 7.643E-3
7.701E-2
1.529E-1
 4 46
21 C066075 vanadium pentoxide CTD 1.202E-5 7.648E-3
7.707E-2
1.606E-1
 5 98
22 CID000008515 SP600125 Stitch 1.349E-5 8.190E-3
8.254E-2
1.802E-1
 8 362
23 CID000044562 d-indobufen Stitch 1.600E-5 9.294E-3
9.366E-2
2.138E-1
 4 50
24 CID005362391 ridogrel Stitch 1.872E-5 9.491E-3
9.564E-2
2.501E-1
 4 52
25 CID000001029 hydroxylysine Stitch 2.016E-5 9.491E-3
9.564E-2
2.693E-1
 5 109
26 CID000023340 NSC49633 Stitch 2.021E-5 9.491E-3
9.564E-2
2.699E-1
 4 53
27 CID000001711 AC1L1C2F Stitch 2.107E-5 9.491E-3
9.564E-2
2.815E-1
 5 110
28 C029955 2-nitrotoluene CTD 2.177E-5 9.491E-3
9.564E-2
2.909E-1
 4 54
29 D017632 Asbestos, Serpentine CTD 2.299E-5 9.491E-3
9.564E-2
3.071E-1
 5 112
30 CID000003414 foscarnet Stitch 2.410E-5 9.491E-3
9.564E-2
3.220E-1
 6 190
31 CID000005213 silibinin Stitch 2.476E-5 9.491E-3
9.564E-2
3.307E-1
 7 285
32 CID000005527 Tranilast sodium Stitch 2.611E-5 9.491E-3
9.564E-2
3.488E-1
 5 115
33 6243 DN Retinoic acid [302-79-4]; Down 200; 13.4uM; MCF7; HT HG-U133A Broad Institute CMAP 2.710E-5 9.491E-3
9.564E-2
3.620E-1
 6 194
34 430 DN rosiglitazone maleate; Down 200; 10uM; PC3; HG-U133A Broad Institute CMAP 2.710E-5 9.491E-3
9.564E-2
3.620E-1
 6 194
35 450 UP 17-AAG; Up 200; 1uM; PC3; HG-U133A Broad Institute CMAP 2.789E-5 9.491E-3
9.564E-2
3.726E-1
 6 195
36 3401 UP Xamoterol hemifumarate [73210-73-8]; Up 200; 5uM; MCF7; HT HG-U133A Broad Institute CMAP 2.871E-5 9.491E-3
9.564E-2
3.835E-1
 6 196
37 CID006711154 DAPH2 Stitch 2.895E-5 9.491E-3
9.564E-2
3.867E-1
 4 58
38 C034096 ethoxyacetic acid CTD 2.927E-5 9.491E-3
9.564E-2
3.910E-1
 3 20
39 CID000122144 351A Stitch 2.927E-5 9.491E-3
9.564E-2
3.910E-1
 3 20
40 C032688 boric acid CTD 2.927E-5 9.491E-3
9.564E-2
3.910E-1
 3 20
41 5069 UP Gemfibrozil [25812-30-0]; Up 200; 16uM; PC3; HT HG-U133A Broad Institute CMAP 2.954E-5 9.491E-3
9.564E-2
3.946E-1
 6 197
42 MESH:D001943/D014212-T Breast Neoplasms affected by Tretinoin CTD Therapeutic 3.079E-5 9.491E-3
9.564E-2
4.113E-1
 5 119
43 4560 UP CP-320650-01 [172079-28-6]; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 3.126E-5 9.491E-3
9.564E-2
4.176E-1
 6 199
44 4062 UP Methacycline hydrochloride [3963-95-9]; Up 200; 8.4uM; PC3; HT HG-U133A Broad Institute CMAP 3.126E-5 9.491E-3
9.564E-2
4.176E-1
 6 199
45 MESH:D001943/D004054-T Breast Neoplasms affected by Diethylstilbestrol CTD Therapeutic 3.312E-5 9.686E-3
9.761E-2
4.424E-1
 4 60
46 CID006327189 boron monoxide Stitch 3.335E-5 9.686E-3
9.761E-2
4.456E-1
 5 121
47 CID000470146 AC1LAKND Stitch 3.771E-5 1.072E-2
1.080E-1
5.038E-1
 4 62
48 MESH:D001943/D001564-M Breast Neoplasms affected by Benzo(a)pyrene CTD Marker 4.050E-5 1.127E-2
1.136E-1
5.410E-1
 5 126
49 C043680 ptaquiloside CTD 4.878E-5 1.330E-2
1.340E-1
6.517E-1
 5 131
50 D007529 Isoflavones CTD 5.069E-5 1.349E-2
1.360E-1
6.771E-1
 6 217
Show 45 more annotations

18: Disease [Display Chart] 1680 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C1800706 Idiopathic Pulmonary Fibrosis DisGeNET Curated 4.797E-6 6.022E-3 4.820E-2 8.060E-3 9 323
2 umls:C0206638 Giant Cell Tumor of Bone DisGeNET Curated 7.169E-6 6.022E-3 4.820E-2 1.204E-2 5 68
3 umls:C0005967 Bone neoplasms DisGeNET Curated 1.162E-5 6.493E-3
5.197E-2
 1.952E-2 5 75
4 umls:C0032026 Pityriasis Rosea DisGeNET BeFree 1.546E-5 6.493E-3
5.197E-2
 2.597E-2 2 2
5 umls:C0034069 Pulmonary Fibrosis DisGeNET Curated 3.434E-5 1.110E-2
8.887E-2
5.769E-2
 8 317
6 umls:C0021655 Insulin Resistance DisGeNET Curated 4.156E-5 1.110E-2
8.887E-2
6.983E-2
 4 49
7 umls:C2960725 Invasive pituitary adenoma DisGeNET BeFree 4.626E-5 1.110E-2
8.887E-2
7.772E-2
 2 3
8 umls:C1956089 Osteophyte DisGeNET BeFree 7.502E-5 1.447E-2
1.158E-1
1.260E-1
 3 21
9 umls:C0017168 Gastroesophageal reflux disease DisGeNET Curated 8.071E-5 1.447E-2
1.158E-1
1.356E-1
 5 112
10 umls:C0011573 Endogenous depression DisGeNET BeFree 9.228E-5 1.447E-2
1.158E-1
1.550E-1
 2 4
11 umls:C0853879 Invasive breast carcinoma DisGeNET BeFree 9.977E-5 1.447E-2
1.158E-1
1.676E-1
 8 369
12 umls:C0206062 Lung Diseases, Interstitial DisGeNET Curated 1.034E-4 1.447E-2
1.158E-1
1.737E-1
 5 118
13 umls:C1623038 Cirrhosis DisGeNET BeFree 1.157E-4 1.496E-2
1.197E-1
1.944E-1
 8 377
14 umls:C0013274 Patent ductus arteriosus DisGeNET Curated 1.283E-4 1.539E-2
1.232E-1
2.155E-1
 3 25
15 umls:C0029456 Osteoporosis DisGeNET Curated 1.977E-4 1.994E-2
1.596E-1
3.321E-1
 7 305
16 umls:C1511291 Breast Cancer Model DisGeNET BeFree 2.096E-4 1.994E-2
1.596E-1
3.521E-1
 4 74
17 umls:C0268335 Ehlers-Danlos syndrome type 1 DisGeNET Curated 2.295E-4 1.994E-2
1.596E-1
3.856E-1
 2 6
18 umls:C0268338 Ehlers-Danlos Syndrome, Type IV DisGeNET Curated 2.295E-4 1.994E-2
1.596E-1
3.856E-1
 2 6
19 umls:C0879615 Stromal Neoplasm DisGeNET BeFree 2.323E-4 1.994E-2
1.596E-1
3.903E-1
 4 76
20 umls:C0259779 Fibrous Dysplasia DisGeNET BeFree 2.465E-4 1.994E-2
1.596E-1
4.141E-1
 3 31
21 umls:C0015302 External exotoses DisGeNET BeFree 2.712E-4 1.994E-2
1.596E-1
4.556E-1
 3 32
22 umls:C0003507 Aortic Valve Stenosis DisGeNET BeFree 2.830E-4 1.994E-2
1.596E-1
4.755E-1
 4 80
23 umls:C1621958 Glioblastoma Multiforme DisGeNET BeFree 3.021E-4 1.994E-2
1.596E-1
5.075E-1
 8 434
24 umls:C0005940 Bone Diseases DisGeNET Curated 3.075E-4 1.994E-2
1.596E-1
5.166E-1
 5 149
25 umls:C0017980 Glycosuria, Renal DisGeNET Curated 3.205E-4 1.994E-2
1.596E-1
5.385E-1
 2 7
26 umls:C1260965 Lipoblastoma DisGeNET Curated 3.205E-4 1.994E-2
1.596E-1
5.385E-1
 2 7
27 umls:C0085932 Skin Diseases, Bullous DisGeNET BeFree 3.205E-4 1.994E-2
1.596E-1
5.385E-1
 2 7
28 umls:C1519670 Tumor Angiogenesis DisGeNET BeFree 3.466E-4 2.080E-2
1.665E-1
5.824E-1
 8 443
29 umls:C0206633 Angiomyolipoma DisGeNET BeFree 3.860E-4 2.162E-2
1.730E-1
6.485E-1
 3 36
30 umls:C0677659 Gastro-esophageal reflux disease with esophagitis DisGeNET BeFree 3.860E-4 2.162E-2
1.730E-1
6.485E-1
 3 36
31 umls:C0205699 Carcinomatosis DisGeNET BeFree 4.263E-4 2.170E-2
1.737E-1
7.161E-1
 2 8
32 umls:C0280474 high-grade childhood cerebral astrocytoma DisGeNET BeFree 4.263E-4 2.170E-2
1.737E-1
7.161E-1
 2 8
33 umls:C0278878 adult glioblastoma DisGeNET BeFree 4.263E-4 2.170E-2
1.737E-1
7.161E-1
 2 8
34 umls:C0014518 Toxic Epidermal Necrolysis DisGeNET Curated 4.535E-4 2.241E-2
1.794E-1
7.619E-1
 3 38
35 umls:C0006267 Bronchiectasis DisGeNET Curated 4.899E-4 2.286E-2
1.830E-1
8.231E-1
 3 39
36 umls:C0014869 Peptic Esophagitis DisGeNET Curated 4.899E-4 2.286E-2
1.830E-1
8.231E-1
 3 39
37 umls:C0035412 Rhabdomyosarcoma DisGeNET Curated 5.379E-4 2.328E-2
1.864E-1
9.037E-1
 7 360
38 umls:C0265344 Donohue Syndrome DisGeNET Curated 5.467E-4 2.328E-2
1.864E-1
9.184E-1
 2 9
39 umls:C0238402 Pycnodysostosis DisGeNET Curated 5.467E-4 2.328E-2
1.864E-1
9.184E-1
 2 9
40 umls:C0333516 Tumor necrosis DisGeNET BeFree 5.626E-4 2.328E-2
1.864E-1
9.452E-1
 5 170
41 umls:C0016059 Fibrosis DisGeNET Curated 5.682E-4 2.328E-2
1.864E-1
9.546E-1
 3 41
42 umls:C0039103 Synovitis DisGeNET Curated 6.368E-4 2.498E-2
1.999E-1
1.000E0
 4 99
43 umls:C0037274 Dermatologic disorders DisGeNET Curated 6.430E-4 2.498E-2
1.999E-1
1.000E0
 7 371
44 umls:C0268800 Simple renal cyst DisGeNET BeFree 6.541E-4 2.498E-2
1.999E-1
1.000E0
 3 43
45 umls:C0029434 Osteogenesis Imperfecta DisGeNET Curated 7.000E-4 2.564E-2
2.052E-1
1.000E0
 3 44
46 umls:C0024117 Chronic Obstructive Airway Disease DisGeNET Curated 7.409E-4 2.564E-2
2.052E-1
1.000E0
 8 497
47 umls:C0032000 Pituitary Adenoma DisGeNET BeFree 7.423E-4 2.564E-2
2.052E-1
1.000E0
 6 274
48 umls:C0085207 Gestational Diabetes DisGeNET Curated 7.473E-4 2.564E-2
2.052E-1
1.000E0
 5 181
49 umls:C0410702 Adolescent idiopathic scoliosis DisGeNET BeFree 7.479E-4 2.564E-2
2.052E-1
1.000E0
 3 45
50 umls:C0024796 Marfan Syndrome DisGeNET Curated 7.978E-4 2.634E-2
2.108E-1
1.000E0
 3 46
Show 45 more annotations