Toppgene analysis for aggregated_1964_log, IC24, positive side

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1: GO: Molecular Function [Display Chart] 574 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005539 glycosaminoglycan binding 1.314E-5 7.543E-3
5.228E-2
 7.543E-3 11 219
2 GO:0008201 heparin binding 4.718E-5 1.215E-2
8.419E-2
 2.708E-2 9 167
3 GO:1901681 sulfur compound binding 6.349E-5 1.215E-2
8.419E-2
 3.644E-2 11 260
4 GO:0043425 bHLH transcription factor binding 2.157E-4 3.096E-2
2.146E-1
1.238E-1
 4 30
5 GO:0036042 long-chain fatty acyl-CoA binding 2.959E-4 3.396E-2
2.354E-1
1.698E-1
 2 3
6 GO:0042043 neurexin family protein binding 4.086E-4 3.838E-2
2.660E-1
2.346E-1
 3 15
7 GO:0004971 AMPA glutamate receptor activity 5.878E-4 3.838E-2
2.660E-1
3.374E-1
 2 4
8 GO:0004768 stearoyl-CoA 9-desaturase activity 5.878E-4 3.838E-2
2.660E-1
3.374E-1
 2 4
9 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 6.018E-4 3.838E-2
2.660E-1
3.454E-1
 3 17
Show 4 more annotations

2: GO: Biological Process [Display Chart] 3351 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0050804 modulation of synaptic transmission 4.714E-9 1.148E-5 9.982E-5 1.580E-5 19 358
2 GO:0010975 regulation of neuron projection development 6.852E-9 1.148E-5 9.982E-5 2.296E-5 22 494
3 GO:0045665 negative regulation of neuron differentiation 1.247E-8 1.393E-5 1.211E-4 4.180E-5 15 228
4 GO:0051961 negative regulation of nervous system development 2.059E-8 1.725E-5 1.499E-4 6.899E-5 17 311
5 GO:0010721 negative regulation of cell development 2.581E-8 1.730E-5 1.504E-4 8.649E-5 18 356
6 GO:0050768 negative regulation of neurogenesis 4.156E-8 2.321E-5 2.018E-4 1.393E-4 16 287
7 GO:0050803 regulation of synapse structure or activity 1.417E-7 6.783E-5 5.898E-4 4.748E-4 15 274
8 GO:0042063 gliogenesis 2.056E-7 8.611E-5 7.487E-4 6.889E-4 15 282
9 GO:0050808 synapse organization 4.794E-7 1.785E-4 1.552E-3 1.607E-3 14 261
10 GO:0031345 negative regulation of cell projection organization 2.261E-6 7.576E-4 6.587E-3 7.576E-3 11 179
11 GO:0007416 synapse assembly 2.999E-6 9.136E-4 7.943E-3 1.005E-2 10 149
12 GO:0010977 negative regulation of neuron projection development 3.588E-6 9.809E-4 8.528E-3 1.202E-2 10 152
13 GO:0050806 positive regulation of synaptic transmission 3.805E-6 9.809E-4 8.528E-3 1.275E-2 10 153
14 GO:0007409 axonogenesis 8.191E-6 1.896E-3 1.648E-2 2.745E-2 17 478
15 GO:0048708 astrocyte differentiation 8.485E-6 1.896E-3 1.648E-2 2.843E-2 7 72
16 GO:0048167 regulation of synaptic plasticity 9.696E-6 2.031E-3 1.766E-2 3.249E-2 10 170
17 GO:0097090 presynaptic membrane organization 1.295E-5 2.536E-3 2.205E-2 4.340E-2 4 15
18 GO:0072330 monocarboxylic acid biosynthetic process 1.362E-5 2.536E-3 2.205E-2 4.566E-2 11 216
19 GO:0010769 regulation of cell morphogenesis involved in differentiation 3.117E-5 5.497E-3 4.779E-2
1.044E-1
 14 375
20 GO:0045666 positive regulation of neuron differentiation 3.303E-5 5.534E-3 4.812E-2
1.107E-1
 14 377
21 GO:0050807 regulation of synapse organization 4.713E-5 7.472E-3
6.497E-2
1.579E-1
 8 127
22 GO:0042391 regulation of membrane potential 4.906E-5 7.472E-3
6.497E-2
1.644E-1
 14 391
23 GO:0010001 glial cell differentiation 6.708E-5 9.534E-3
8.290E-2
2.248E-1
 10 213
24 GO:0050890 cognition 6.829E-5 9.534E-3
8.290E-2
2.288E-1
 12 304
25 GO:0001505 regulation of neurotransmitter levels 7.252E-5 9.662E-3
8.400E-2
2.430E-1
 10 215
26 GO:0014002 astrocyte development 7.883E-5 9.662E-3
8.400E-2
2.641E-1
 4 23
27 GO:0097105 presynaptic membrane assembly 8.309E-5 9.662E-3
8.400E-2
2.784E-1
 3 9
28 GO:0097091 synaptic vesicle clustering 8.309E-5 9.662E-3
8.400E-2
2.784E-1
 3 9
29 GO:0030900 forebrain development 8.361E-5 9.662E-3
8.400E-2
2.802E-1
 14 411
30 GO:1902722 positive regulation of prolactin secretion 1.028E-4 1.149E-2
9.988E-2
3.446E-1
 2 2
31 GO:0007611 learning or memory 1.111E-4 1.201E-2
1.044E-1
3.722E-1
 11 272
32 GO:0050805 negative regulation of synaptic transmission 1.237E-4 1.295E-2
1.126E-1
4.145E-1
 6 76
33 GO:0072073 kidney epithelium development 1.382E-4 1.403E-2
1.220E-1
4.631E-1
 8 148
34 GO:0050773 regulation of dendrite development 1.516E-4 1.494E-2
1.299E-1
5.081E-1
 8 150
35 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway 1.608E-4 1.497E-2
1.301E-1
5.388E-1
 3 11
36 GO:0015810 aspartate transport 1.608E-4 1.497E-2
1.301E-1
5.388E-1
 3 11
37 GO:0016358 dendrite development 1.732E-4 1.568E-2
1.364E-1
5.803E-1
 10 239
38 GO:0007411 axon guidance 1.853E-4 1.634E-2
1.420E-1
6.208E-1
 10 241
39 GO:0097485 neuron projection guidance 1.916E-4 1.646E-2
1.431E-1
6.419E-1
 10 242
40 GO:0050673 epithelial cell proliferation 2.053E-4 1.720E-2
1.495E-1
6.879E-1
 13 394
41 GO:0030208 dermatan sulfate biosynthetic process 2.128E-4 1.739E-2
1.512E-1
7.130E-1
 3 12
42 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 2.360E-4 1.883E-2
1.637E-1
7.907E-1
 8 160
43 GO:0001764 neuron migration 2.462E-4 1.896E-2
1.649E-1
8.249E-1
 8 161
44 GO:0010812 negative regulation of cell-substrate adhesion 2.587E-4 1.896E-2
1.649E-1
8.670E-1
 5 56
45 GO:0015740 C4-dicarboxylate transport 2.745E-4 1.896E-2
1.649E-1
9.200E-1
 3 13
46 GO:0036109 alpha-linolenic acid metabolic process 2.745E-4 1.896E-2
1.649E-1
9.200E-1
 3 13
47 GO:0030205 dermatan sulfate metabolic process 2.745E-4 1.896E-2
1.649E-1
9.200E-1
 3 13
48 GO:0007638 mechanosensory behavior 2.745E-4 1.896E-2
1.649E-1
9.200E-1
 3 13
49 GO:0051963 regulation of synapse assembly 2.773E-4 1.896E-2
1.649E-1
9.292E-1
 6 88
50 GO:0009449 gamma-aminobutyric acid biosynthetic process 3.065E-4 1.938E-2
1.685E-1
1.000E0
 2 3
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 332 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043197 dendritic spine 4.578E-8 8.787E-6 5.610E-5 1.520E-5 12 152
2 GO:0044309 neuron spine 5.293E-8 8.787E-6 5.610E-5 1.757E-5 12 154
3 GO:0030133 transport vesicle 1.300E-6 1.438E-4 9.182E-4 4.315E-4 16 374
4 GO:0098794 postsynapse 3.661E-6 3.039E-4 1.940E-3 1.215E-3 17 454
5 GO:0031012 extracellular matrix 1.153E-5 7.656E-4 4.887E-3 3.828E-3 16 444
6 GO:0031256 leading edge membrane 2.156E-5 1.193E-3 7.617E-3 7.159E-3 9 150
7 GO:0005578 proteinaceous extracellular matrix 3.151E-5 1.495E-3 9.542E-3 1.046E-2 14 379
8 GO:0070382 exocytic vesicle 6.312E-5 2.620E-3 1.672E-2 2.096E-2 9 172
9 GO:0031252 cell leading edge 1.649E-4 5.609E-3 3.580E-2
5.475E-2
 13 389
10 GO:0098793 presynapse 1.834E-4 5.609E-3 3.580E-2
6.089E-2
 12 341
11 GO:0008021 synaptic vesicle 1.858E-4 5.609E-3 3.580E-2
6.169E-2
 8 156
12 GO:0030658 transport vesicle membrane 2.028E-4 5.610E-3 3.581E-2
6.732E-2
 8 158
13 GO:0060076 excitatory synapse 2.962E-4 7.564E-3 4.829E-2
9.833E-2
 10 258
14 GO:0044420 extracellular matrix component 6.206E-4 1.467E-2
9.366E-2
2.060E-1
 7 143
15 GO:0014069 postsynaptic density 7.071E-4 1.467E-2
9.366E-2
2.348E-1
 9 238
16 GO:0099572 postsynaptic specialization 7.071E-4 1.467E-2
9.366E-2
2.348E-1
 9 238
17 GO:0097060 synaptic membrane 9.553E-4 1.823E-2
1.164E-1
3.172E-1
 10 300
18 GO:0044326 dendritic spine neck 9.883E-4 1.823E-2
1.164E-1
3.281E-1
 2 5
19 GO:0033267 axon part 1.193E-3 2.085E-2
1.331E-1
3.962E-1
 10 309
20 GO:0030139 endocytic vesicle 1.539E-3 2.518E-2
1.608E-1
5.110E-1
 9 266
21 GO:0032587 ruffle membrane 1.593E-3 2.518E-2
1.608E-1
5.289E-1
 5 84
22 GO:0031253 cell projection membrane 2.213E-3 3.340E-2
2.132E-1
7.347E-1
 10 336
23 GO:0030426 growth cone 2.500E-3 3.411E-2
2.177E-1
8.301E-1
 7 182
24 GO:0045121 membrane raft 2.568E-3 3.411E-2
2.177E-1
8.526E-1
 10 343
25 GO:0098857 membrane microdomain 2.568E-3 3.411E-2
2.177E-1
8.526E-1
 10 343
26 GO:0005796 Golgi lumen 2.863E-3 3.463E-2
2.211E-1
9.506E-1
 5 96
27 GO:0030427 site of polarized growth 2.908E-3 3.463E-2
2.211E-1
9.655E-1
 7 187
28 GO:0043198 dendritic shaft 3.127E-3 3.463E-2
2.211E-1
1.000E0
 4 60
29 GO:0030662 coated vesicle membrane 3.179E-3 3.463E-2
2.211E-1
1.000E0
 6 142
30 GO:0099501 exocytic vesicle membrane 3.321E-3 3.463E-2
2.211E-1
1.000E0
 4 61
31 GO:0030672 synaptic vesicle membrane 3.321E-3 3.463E-2
2.211E-1
1.000E0
 4 61
32 GO:0032281 AMPA glutamate receptor complex 3.338E-3 3.463E-2
2.211E-1
1.000E0
 3 30
33 GO:0008250 oligosaccharyltransferase complex 4.302E-3 4.328E-2
2.763E-1
1.000E0
 2 10
34 GO:0030666 endocytic vesicle membrane 5.188E-3 4.908E-2
3.133E-1
1.000E0
 6 157
35 GO:0042612 MHC class I protein complex 5.223E-3 4.908E-2
3.133E-1
1.000E0
 2 11
36 GO:0005604 basement membrane 5.322E-3 4.908E-2
3.133E-1
1.000E0
 5 111
Show 31 more annotations

4: Human Phenotype [Display Chart] 389 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0003144 Increased serum serotonin {has synonym type="layperson"} 1.034E-4 9.718E-3
6.358E-2
 4.021E-2 3 9
2 HP:0100686 Enthesitis 1.210E-4 9.718E-3
6.358E-2
 4.706E-2 2 2
3 HP:0012122 Anterior uveitis 1.210E-4 9.718E-3
6.358E-2
 4.706E-2 2 2
4 HP:0000728 Impaired ability to form peer relationships 1.465E-4 9.718E-3
6.358E-2
5.699E-2
 3 10
5 HP:0000723 Restrictive behavior 1.999E-4 9.718E-3
6.358E-2
7.775E-2
 3 11
6 HP:0000732 Inflexible adherence to routines or rituals 1.999E-4 9.718E-3
6.358E-2
7.775E-2
 3 11
7 HP:0000758 Impaired use of nonverbal behaviors {has synonym type="layperson"} 1.999E-4 9.718E-3
6.358E-2
7.775E-2
 3 11
8 HP:0000721 Lack of spontaneous play {has synonym type="layperson"} 1.999E-4 9.718E-3
6.358E-2
7.775E-2
 3 11
9 HP:0002332 Lack of peer relationships {has synonym type="layperson"} 3.603E-4 1.557E-2
1.019E-1
1.402E-1
 2 3
10 HP:0001426 Multifactorial inheritance 4.480E-4 1.743E-2
1.140E-1
1.743E-1
 6 91
11 HP:0000717 Autism {has synonym type="layperson"} 8.473E-4 2.996E-2
1.960E-1
3.296E-1
 5 68
12 HP:0000300 Oval face {has synonym type="layperson"} 1.184E-3 3.838E-2
2.511E-1
4.606E-1
 2 5
Show 7 more annotations

5: Mouse Phenotype [Display Chart] 2680 annotations before applied cutoff / 9299 genes in category

No results to display

6: Domain [Display Chart] 1112 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR020089 PTN/MK N dom InterPro 1.012E-4 8.660E-3
6.574E-2
1.126E-1
 2 2
2 PS00620 PTN MK 2 PROSITE 1.012E-4 8.660E-3
6.574E-2
1.126E-1
 2 2
3 2.30.90.10 - Gene3D 1.012E-4 8.660E-3
6.574E-2
1.126E-1
 2 2
4 PF05196 PTN MK N Pfam 1.012E-4 8.660E-3
6.574E-2
1.126E-1
 2 2
5 SM00193 PTN SMART 1.012E-4 8.660E-3
6.574E-2
1.126E-1
 2 2
6 PF01091 PTN MK C Pfam 1.012E-4 8.660E-3
6.574E-2
1.126E-1
 2 2
7 IPR020091 PTN/MK diS InterPro 1.012E-4 8.660E-3
6.574E-2
1.126E-1
 2 2
8 PD005592 PTN MK hepar bd ProDom 1.012E-4 8.660E-3
6.574E-2
1.126E-1
 2 2
9 2.20.60.10 - Gene3D 1.012E-4 8.660E-3
6.574E-2
1.126E-1
 2 2
10 IPR020092 PTN MK heparin-bd GF CS InterPro 1.012E-4 8.660E-3
6.574E-2
1.126E-1
 2 2
11 IPR000762 Midkine heparin-bd GF InterPro 1.012E-4 8.660E-3
6.574E-2
1.126E-1
 2 2
12 PS00619 PTN MK 1 PROSITE 1.012E-4 8.660E-3
6.574E-2
1.126E-1
 2 2
13 IPR020090 PTN/MK C dom InterPro 1.012E-4 8.660E-3
6.574E-2
1.126E-1
 2 2
14 PS50853 FN3 PROSITE 1.939E-4 1.256E-2
9.536E-2
2.157E-1
 9 199
15 3.40.50.1820 - Gene3D 2.058E-4 1.256E-2
9.536E-2
2.289E-1
 7 119
16 IPR029058 AB hydrolase InterPro 2.058E-4 1.256E-2
9.536E-2
2.289E-1
 7 119
17 PF00041 fn3 Pfam 2.434E-4 1.256E-2
9.536E-2
2.706E-1
 8 162
18 IPR019819 Carboxylesterase B CS InterPro 2.682E-4 1.256E-2
9.536E-2
2.983E-1
 3 13
19 IPR003961 FN3 dom InterPro 2.792E-4 1.256E-2
9.536E-2
3.104E-1
 9 209
20 PS00575 MYELIN PLP 1 PROSITE 3.017E-4 1.256E-2
9.536E-2
3.355E-1
 2 3
21 SM00002 PLP SMART 3.017E-4 1.256E-2
9.536E-2
3.355E-1
 2 3
22 IPR018237 Myelin PLP CS InterPro 3.017E-4 1.256E-2
9.536E-2
3.355E-1
 2 3
23 IPR001614 Myelin PLP InterPro 3.017E-4 1.256E-2
9.536E-2
3.355E-1
 2 3
24 PS01004 MYELIN PLP 2 PROSITE 3.017E-4 1.256E-2
9.536E-2
3.355E-1
 2 3
25 PF01275 Myelin PLP Pfam 3.017E-4 1.256E-2
9.536E-2
3.355E-1
 2 3
26 PF00135 COesterase Pfam 3.389E-4 1.256E-2
9.536E-2
3.768E-1
 3 14
27 SM00294 4.1m SMART 3.389E-4 1.256E-2
9.536E-2
3.768E-1
 3 14
28 IPR002018 CarbesteraseB InterPro 3.389E-4 1.256E-2
9.536E-2
3.768E-1
 3 14
29 PS00941 CARBOXYLESTERASE B 2 PROSITE 3.389E-4 1.256E-2
9.536E-2
3.768E-1
 3 14
30 IPR003585 Neurexin-like InterPro 3.389E-4 1.256E-2
9.536E-2
3.768E-1
 3 14
31 PS50025 LAM G DOMAIN PROSITE 5.663E-4 1.709E-2
1.297E-1
6.298E-1
 4 38
32 SM00060 FN3 SMART 5.916E-4 1.709E-2
1.297E-1
6.579E-1
 8 185
33 IPR000580 TSC-22 Dip Bun InterPro 5.994E-4 1.709E-2
1.297E-1
6.665E-1
 2 4
34 PD007152 TSC-22 Dip Bun ProDom 5.994E-4 1.709E-2
1.297E-1
6.665E-1
 2 4
35 IPR026966 Neurofascin/L1/NrCAM C InterPro 5.994E-4 1.709E-2
1.297E-1
6.665E-1
 2 4
36 PF13882 Bravo FIGEY Pfam 5.994E-4 1.709E-2
1.297E-1
6.665E-1
 2 4
37 IPR009138 Neural cell adh InterPro 5.994E-4 1.709E-2
1.297E-1
6.665E-1
 2 4
38 PS01289 TSC22 PROSITE 5.994E-4 1.709E-2
1.297E-1
6.665E-1
 2 4
39 PF01166 TSC22 Pfam 5.994E-4 1.709E-2
1.297E-1
6.665E-1
 2 4
40 PF02210 Laminin G 2 Pfam 6.903E-4 1.919E-2
1.457E-1
7.676E-1
 4 40
41 IPR002413 V5 allergen InterPro 9.923E-4 2.570E-2
1.951E-1
1.000E0
 2 5
42 IPR000460 Nlgn InterPro 9.923E-4 2.570E-2
1.951E-1
1.000E0
 2 5
43 SM00282 LamG SMART 9.937E-4 2.570E-2
1.951E-1
1.000E0
 4 44
44 IPR018503 Tetraspanin CS InterPro 1.175E-3 2.971E-2
2.255E-1
1.000E0
 3 21
45 IPR004043 LCCL InterPro 1.479E-3 3.224E-2
2.447E-1
1.000E0
 2 6
46 PS50820 LCCL PROSITE 1.479E-3 3.224E-2
2.447E-1
1.000E0
 2 6
47 PF03815 LCCL Pfam 1.479E-3 3.224E-2
2.447E-1
1.000E0
 2 6
48 2.170.130.20 - Gene3D 1.479E-3 3.224E-2
2.447E-1
1.000E0
 2 6
49 IPR010579 MHC I a C InterPro 1.479E-3 3.224E-2
2.447E-1
1.000E0
 2 6
50 PF06623 MHC I C Pfam 1.479E-3 3.224E-2
2.447E-1
1.000E0
 2 6
Show 45 more annotations

7: Pathway [Display Chart] 845 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 83069 Cell adhesion molecules (CAMs) BioSystems: KEGG 5.491E-6 4.640E-3 3.395E-2 4.640E-3 10 147
2 83042 PPAR signaling pathway BioSystems: KEGG 1.114E-5 4.706E-3 3.443E-2 9.411E-3 7 69
3 137952 Syndecan-3-mediated signaling events BioSystems: Pathway Interaction Database 3.158E-5 8.896E-3
6.509E-2
 2.669E-2 4 17
4 106516 Transmission across Chemical Synapses BioSystems: REACTOME 7.902E-5 1.669E-2
1.221E-1
6.677E-2
 10 200
5 645305 A tetrasaccharide linker sequence is required for GAG synthesis BioSystems: REACTOME 1.835E-4 2.541E-2
1.859E-1
1.551E-1
 4 26
6 868084 Fatty acid metabolism BioSystems: KEGG 1.873E-4 2.541E-2
1.859E-1
1.582E-1
 5 48
7 645310 Dermatan sulfate biosynthesis BioSystems: REACTOME 2.105E-4 2.541E-2
1.859E-1
1.779E-1
 3 11
8 645344 alpha-linolenic acid (ALA) metabolism BioSystems: REACTOME 3.590E-4 3.370E-2
2.466E-1
3.033E-1
 3 13
9 645343 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism BioSystems: REACTOME 3.590E-4 3.370E-2
2.466E-1
3.033E-1
 3 13
10 645311 CS/DS degradation BioSystems: REACTOME 4.531E-4 3.829E-2
2.802E-1
3.829E-1
 3 14
11 161003 L1CAM interactions BioSystems: REACTOME 6.293E-4 4.127E-2
3.019E-1
5.318E-1
 6 94
12 P00039 Metabotropic glutamate receptor group III pathway PantherDB 7.233E-4 4.127E-2
3.019E-1
6.112E-1
 5 64
13 106532 Neurotransmitter uptake and Metabolism In Glial Cells BioSystems: REACTOME 7.325E-4 4.127E-2
3.019E-1
6.190E-1
 2 4
14 106533 Astrocytic Glutamate-Glutamine Uptake And Metabolism BioSystems: REACTOME 7.325E-4 4.127E-2
3.019E-1
6.190E-1
 2 4
15 106539 Activation of AMPA receptors BioSystems: REACTOME 7.325E-4 4.127E-2
3.019E-1
6.190E-1
 2 4
16 M7552 Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy MSigDB C2 BIOCARTA (v5.1) 9.832E-4 4.887E-2
3.576E-1
8.308E-1
 3 18
17 M1389 Sprouty regulation of tyrosine kinase signals MSigDB C2 BIOCARTA (v5.1) 9.832E-4 4.887E-2
3.576E-1
8.308E-1
 3 18
Show 12 more annotations

8: Pubmed [Display Chart] 28523 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19086053:gr Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. GeneRIF 1.543E-10 1.383E-6 1.498E-5 4.400E-6 13 300
2 19086053 Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. Pubmed 1.543E-10 1.383E-6 1.498E-5 4.400E-6 13 300
3 17368428:gr Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease. GeneRIF 1.939E-10 1.383E-6 1.498E-5 5.532E-6 4 4
4 17368428 Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease. Pubmed 1.939E-10 1.383E-6 1.498E-5 5.532E-6 4 4
5 19736351 Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation. Pubmed 1.783E-9 8.474E-6 9.182E-5 5.084E-5 6 31
6 19736351:gr Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation. GeneRIF 1.783E-9 8.474E-6 9.182E-5 5.084E-5 6 31
7 16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Pubmed 4.672E-9 1.785E-5 1.934E-4 1.333E-4 11 257
8 24722188 Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Pubmed 5.007E-9 1.785E-5 1.934E-4 1.428E-4 13 400
9 18448176 Measurements of secretogranins II, III, V and proconvertases 1/3 and 2 in plasma from patients with neuroendocrine tumours. Pubmed 5.237E-8 1.245E-4 1.349E-3 1.494E-3 3 3
10 18448176:gr Measurements of secretogranins II, III, V and proconvertases 1/3 and 2 in plasma from patients with neuroendocrine tumours. GeneRIF 5.237E-8 1.245E-4 1.349E-3 1.494E-3 3 3
11 20548248 Correlation between HLA alleles and EGFR mutation in Japanese patients with adenocarcinoma of the lung. Pubmed 5.237E-8 1.245E-4 1.349E-3 1.494E-3 3 3
12 20548248:gr Correlation between HLA alleles and EGFR mutation in Japanese patients with adenocarcinoma of the lung. GeneRIF 5.237E-8 1.245E-4 1.349E-3 1.494E-3 3 3
13 18923447:gr SOX9 and SOX10 but not BRN2 are required for nestin expression in human melanoma cells. GeneRIF 2.089E-7 4.256E-4 4.612E-3 5.959E-3 3 4
14 18923447 SOX9 and SOX10 but not BRN2 are required for nestin expression in human melanoma cells. Pubmed 2.089E-7 4.256E-4 4.612E-3 5.959E-3 3 4
15 15822905 Phosphoproteomic analysis of synaptosomes from human cerebral cortex. Pubmed 4.442E-7 8.447E-4 9.152E-3 1.267E-2 4 17
16 22589738 Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. Pubmed 7.885E-7 1.021E-3 1.107E-2 2.249E-2 8 193
17 12853948 The DNA sequence of human chromosome 7. Pubmed 1.000E-6 1.021E-3 1.107E-2 2.854E-2 11 438
18 15620359 Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Pubmed 1.039E-6 1.021E-3 1.107E-2 2.963E-2 3 6
19 26455392 EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling. Pubmed 1.039E-6 1.021E-3 1.107E-2 2.963E-2 3 6
20 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 2.221E-6 1.021E-3 1.107E-2
6.336E-2
 10 383
21 19453261:gr High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. GeneRIF 2.221E-6 1.021E-3 1.107E-2
6.336E-2
 10 383
22 20936779 A human MAP kinase interactome. Pubmed 2.721E-6 1.021E-3 1.107E-2
7.762E-2
 11 486
23 23383108 Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. Pubmed 3.644E-6 1.021E-3 1.107E-2
1.039E-1
 6 108
24 20201926 Human variation in alcohol response is influenced by variation in neuronal signaling genes. Pubmed 4.251E-6 1.021E-3 1.107E-2
1.213E-1
 7 171
25 20201926:gr Human variation in alcohol response is influenced by variation in neuronal signaling genes. GeneRIF 4.251E-6 1.021E-3 1.107E-2
1.213E-1
 7 171
26 10772929 LDL receptor-related protein as a component of the midkine receptor. Pubmed 4.326E-6 1.021E-3 1.107E-2
1.234E-1
 3 9
27 20512145 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Pubmed 4.326E-6 1.021E-3 1.107E-2
1.234E-1
 3 9
28 19199708 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Pubmed 4.415E-6 1.021E-3 1.107E-2
1.259E-1
 10 414
29 20628624 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". Pubmed 4.418E-6 1.021E-3 1.107E-2
1.260E-1
 7 172
30 20628624:gr Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". GeneRIF 4.418E-6 1.021E-3 1.107E-2
1.260E-1
 7 172
31 16303743 Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Pubmed 6.151E-6 1.021E-3 1.107E-2
1.755E-1
 10 430
32 21994772 The natural killer cell cytotoxic function is modulated by HIV-1 accessory proteins. Pubmed 6.164E-6 1.021E-3 1.107E-2
1.758E-1
 3 10
33 21078624 Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. Pubmed 6.385E-6 1.021E-3 1.107E-2
1.821E-1
 6 119
34 24189400 Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms. Pubmed 6.409E-6 1.021E-3 1.107E-2
1.828E-1
 8 256
35 20195357 A comprehensive resource of interacting protein regions for refining human transcription factor networks. Pubmed 7.912E-6 1.021E-3 1.107E-2
2.257E-1
 7 188
36 22980333 Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host. Pubmed 8.451E-6 1.021E-3 1.107E-2
2.411E-1
 3 11
37 25827531 Immune evasion activities of accessory proteins Vpu, Nef and Vif are conserved in acute and chronic HIV-1 infection. Pubmed 8.451E-6 1.021E-3 1.107E-2
2.411E-1
 3 11
38 19571811 Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Pubmed 8.451E-6 1.021E-3 1.107E-2
2.411E-1
 3 11
39 7566098 Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. Pubmed 8.772E-6 1.021E-3 1.107E-2
2.502E-1
 7 191
40 22871361:gr Recombinant expression and purification of heparin binding proteins: midkine and pleiotrophin from Escherichia coli. GeneRIF 1.407E-5 1.021E-3 1.107E-2
4.013E-1
 2 2
41 12029127:gr Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. GeneRIF 1.407E-5 1.021E-3 1.107E-2
4.013E-1
 2 2
42 20650849 [Cloning and sequencing HLA-A and -B genomic DNA and analyzing polymorphism in regulatory regions in Chinese Han individuals]. Pubmed 1.407E-5 1.021E-3 1.107E-2
4.013E-1
 2 2
43 18463253:gr Glutamate transporters regulate lesion-induced plasticity in the developing somatosensory cortex. GeneRIF 1.407E-5 1.021E-3 1.107E-2
4.013E-1
 2 2
44 23431752 Analysis of the genes encoding neuroligins NLGN3 and NLGN4 in Bulgarian patients with autism. Pubmed 1.407E-5 1.021E-3 1.107E-2
4.013E-1
 2 2
45 12029127 Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Pubmed 1.407E-5 1.021E-3 1.107E-2
4.013E-1
 2 2
46 12047355:gr HLA class I polymorphism in a Moroccan population from Casablanca. GeneRIF 1.407E-5 1.021E-3 1.107E-2
4.013E-1
 2 2
47 16704965 The frequency of HLA class I alleles in Japanese patients with bone marrow failure. Pubmed 1.407E-5 1.021E-3 1.107E-2
4.013E-1
 2 2
48 16648628:gr Versican G3 domain regulates neurite growth and synaptic transmission of hippocampal neurons by activation of epidermal growth factor receptor. GeneRIF 1.407E-5 1.021E-3 1.107E-2
4.013E-1
 2 2
49 11010837:gr HLA class I alleles associated with susceptibility or resistance to human immunodeficiency virus type 1 infection among a population in Chaco Province, Argentina. GeneRIF 1.407E-5 1.021E-3 1.107E-2
4.013E-1
 2 2
50 12144620 HLA-A and HLA-B in Kenya, Africa: allele frequencies and identification of HLA-B*1567 and HLA-B*4426. Pubmed 1.407E-5 1.021E-3 1.107E-2
4.013E-1
 2 2
Show 45 more annotations

9: Interaction [Display Chart] 3778 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:MDK MDK interactions 1.640E-7 6.194E-4 5.460E-3 6.194E-4 6 24
2 int:ARMC1 ARMC1 interactions 4.706E-6 5.766E-3
5.083E-2
 1.778E-2 6 41
3 int:NUFIP1 NUFIP1 interactions 8.442E-6 5.766E-3
5.083E-2
 3.189E-2 8 95
4 int:PTPRZ1 PTPRZ1 interactions 8.608E-6 5.766E-3
5.083E-2
 3.252E-2 4 13
5 int:SCOC SCOC interactions 8.608E-6 5.766E-3
5.083E-2
 3.252E-2 4 13
6 int:DNAAF2 DNAAF2 interactions 9.158E-6 5.766E-3
5.083E-2
 3.460E-2 7 69
7 int:NRXN1 NRXN1 interactions 1.851E-5 9.990E-3
8.806E-2
6.993E-2
 5 31
8 int:TNR TNR interactions 2.136E-5 1.009E-2
8.892E-2
8.071E-2
 4 16
9 int:HAX1 HAX1 interactions 4.119E-5 1.676E-2
1.477E-1
1.556E-1
 8 118
10 int:SDC3 SDC3 interactions 4.436E-5 1.676E-2
1.477E-1
1.676E-1
 4 19
11 int:DGUOK DGUOK interactions 7.613E-5 2.615E-2
2.305E-1
2.876E-1
 6 66
12 int:PTN PTN interactions 9.640E-5 2.856E-2
2.517E-1
3.642E-1
 7 99
13 int:GRIP2 GRIP2 interactions 9.826E-5 2.856E-2
2.517E-1
3.712E-1
 3 9
14 int:CACNA1A CACNA1A interactions 1.315E-4 3.508E-2
3.092E-1
4.968E-1
 7 104
15 int:CNTN2 CNTN2 interactions 1.393E-4 3.508E-2
3.092E-1
5.261E-1
 3 10
Show 10 more annotations

10: Cytoband [Display Chart] 170 annotations before applied cutoff / 34661 genes in category

No results to display

11: Transcription Factor Binding Site [Display Chart] 515 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$TST1 01 V$TST1 01 2.785E-6 9.937E-4 6.780E-3 1.434E-3 13 218
2 YYCATTCAWW UNKNOWN YYCATTCAWW UNKNOWN 3.859E-6 9.937E-4 6.780E-3 1.987E-3 11 158
3 V$BRN2 01 V$BRN2 01 3.129E-5 5.371E-3 3.664E-2 1.611E-2 11 197
4 WTTGKCTG UNKNOWN WTTGKCTG UNKNOWN 4.991E-5 6.426E-3 4.384E-2 2.570E-2 16 415
5 WTGAAAT UNKNOWN WTGAAAT UNKNOWN 1.228E-4 1.265E-2
8.631E-2
6.325E-2
 17 496
6 V$HFH3 01 V$HFH3 01 1.839E-4 1.578E-2
1.077E-1
9.470E-2
 9 163
7 AAAYWAACM V$HFH4 01 AAAYWAACM V$HFH4 01 2.594E-4 1.872E-2
1.277E-1
1.336E-1
 10 209
8 V$SOX5 01 V$SOX5 01 2.909E-4 1.872E-2
1.277E-1
1.498E-1
 10 212
9 V$OCT C V$OCT C 3.635E-4 2.013E-2
1.373E-1
1.872E-1
 10 218
10 V$OCT Q6 V$OCT Q6 3.908E-4 2.013E-2
1.373E-1
2.013E-1
 10 220
11 V$OCT1 Q5 01 V$OCT1 Q5 01 4.351E-4 2.037E-2
1.390E-1
2.241E-1
 10 223
12 V$FOXJ2 02 V$FOXJ2 02 5.710E-4 2.451E-2
1.672E-1
2.941E-1
 9 190
13 V$CDP 02 V$CDP 02 9.544E-4 3.743E-2
2.554E-1
4.915E-1
 6 92
14 V$HNF4 Q6 V$HNF4 Q6 1.018E-3 3.743E-2
2.554E-1
5.241E-1
 9 206
15 V$OCT1 Q6 V$OCT1 Q6 1.245E-3 4.197E-2
2.863E-1
6.412E-1
 9 212
16 V$PAX4 04 V$PAX4 04 1.304E-3 4.197E-2
2.863E-1
6.716E-1
 8 172
17 V$GATA C V$GATA C 1.418E-3 4.296E-2
2.931E-1
7.304E-1
 9 216
18 V$LYF1 01 V$LYF1 01 1.714E-3 4.686E-2
3.197E-1
8.827E-1
 9 222
19 YGCANTGCR UNKNOWN YGCANTGCR UNKNOWN 1.801E-3 4.686E-2
3.197E-1
9.275E-1
 6 104
20 RYAAAKNNNNNNTTGW UNKNOWN RYAAAKNNNNNNTTGW UNKNOWN 1.820E-3 4.686E-2
3.197E-1
9.371E-1
 5 71
21 V$OCT1 B V$OCT1 B 1.937E-3 4.751E-2
3.241E-1
9.977E-1
 9 226
Show 16 more annotations

12: Gene Family [Display Chart] 103 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 555 Fibronectin type III domain containing|Immunoglobulin like domain containing genenames.org 1.719E-6 1.770E-4 9.235E-4 1.770E-4 9 160
2 925 Granins genenames.org 1.771E-5 9.119E-4 4.757E-3 1.824E-3 3 8
3 1200 X-linked mental retardation|Glutamate ionotropic receptor AMPA type subunits genenames.org 2.829E-4 7.285E-3 3.800E-2 2.914E-2 2 4
4 574 Hyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing genenames.org 2.829E-4 7.285E-3 3.800E-2 2.914E-2 2 4
5 813 Protein tyrosine phosphatases, receptor type genenames.org 3.937E-4 8.111E-3 4.231E-2 4.055E-2 3 21
6 593 CD molecules|V-set domain containing|I-set domain containing|Sialic acid binding Ig like lectins genenames.org 8.990E-4 1.543E-2
8.051E-2
9.260E-2
 6 161
7 553 Fatty acid desaturases genenames.org 1.296E-3 1.908E-2
9.952E-2
1.335E-1
 2 8
8 768 CD molecules|Tetraspanins genenames.org 1.520E-3 1.957E-2
1.021E-1
1.566E-1
 3 33
9 445 Oligosaccharyltransferase complex subunits genenames.org 3.001E-3 3.434E-2
1.792E-1
3.091E-1
 2 12
10 1220 PDZ domain containing genenames.org 4.140E-3 4.265E-2
2.225E-1
4.265E-1
 5 152
Show 5 more annotations

13: Coexpression [Display Chart] 6467 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2892 Genes up-regulated in epithelial kidney cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v5.1) 1.537E-18 9.942E-15 9.298E-14 9.942E-15 20 143
2 M2115 Genes correlated with proneural type of glioblastoma multiforme tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.117E-16 3.613E-13 3.379E-12 7.227E-13 20 177
3 M1796 The glioblastoma multiforme (GBM) plasticity signature: genes up-regulated in neural stem cells (NSC) with double knockout of TP53 and PTEN [GeneID=7157;5728] vs those with knockout of TP53 alone. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.699E-12 2.091E-8 1.955E-7 6.272E-8 18 250
4 M2142 Genes up-regulated in SH-SY5Y cells (neuroblastoma) after knockdown of NF1 [GeneID=4763] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.420E-11 3.913E-8 3.659E-7 1.565E-7 14 139
5 M1784 Genes changed in U373-MG cells (malignant glioma) upon treatment with arsenic trioxide [PubChem=14888], a chemical that can cause autophagic cell death. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.911E-11 8.939E-8 8.359E-7 4.469E-7 13 123
6 M4665 Genes down-regulated in glomeruli of kidneys from patients with diabetic nephropathy (type 2 diabetes mellitus). MSigDB C2: CGP Curated Gene Sets (v5.1) 3.020E-10 3.255E-7 3.044E-6 1.953E-6 21 434
7 M13206 Genes down-regulated in TC71 and EWS502 cells (Ewing's sarcoma) by EWSR1-FLI1 [GeneID=2130;2314] as inferred from RNAi knockdown of this fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.475E-10 6.906E-7 6.458E-6 4.834E-6 18 326
8 M2573 Genes consistently up-regulated in mammary stem cells both in mouse and human species. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.572E-9 2.079E-6 1.944E-5 1.663E-5 21 489
9 M2013 Genes with low-CpG-density promoters (LCP) bearing histone H3 trimethylation mark at K4 (H3K4me3) in neural progenitor cells (NPC). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.916E-9 2.095E-6 1.959E-5 1.885E-5 20 445
10 M10276 Genes down-regulated in the neural crest stem cells (NCS), defined as p75+/HNK1+ [GeneID=4804;27087]. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.007E-9 5.178E-6 4.843E-5 5.178E-5 11 118
11 M2581 Genes up-regulated in the HSC supportive stromal cell lines. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.687E-9 5.695E-6 5.326E-5 6.264E-5 16 297
12 M2697 Genes down-regulated in NCI-60 panel of cell lines with mutated TP53 [Gene ID=7157]. MSigDB C6: Oncogenic Signatures (v5.1) 1.692E-8 9.120E-6 8.529E-5 1.094E-4 13 192
13 M7184 Genes up-regulated in glioblastoma cell lines displaying spherical growth (cluster-1) compared to those displaying semiadherent or adherent growth phenotype (cluster-2). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.125E-8 1.057E-5 9.888E-5 1.374E-4 6 21
14 M1885 Genes down-regulated in vascular smooth muscle cells (VSMC) by MAPK8 (JNK1) [GeneID=5599]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.944E-8 1.360E-5 1.272E-4 1.904E-4 17 366
15 M6738 Genes up-regulated in T cells: CD4 [GeneID=920] versus CD8. MSigDB C7: Immunologic Signatures (v5.1) 7.691E-8 3.316E-5 3.101E-4 4.974E-4 12 181
16 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.451E-8 3.416E-5 3.194E-4 5.465E-4 14 260
17 M13256 Genes down-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.309E-7 4.978E-5 4.655E-4 8.462E-4 12 190
18 M2715 Genes down-regulated in MEF cells (embryonic fibroblasts) with knockout of SNF5 [Gene ID=6598] gene. MSigDB C6: Oncogenic Signatures (v5.1) 2.135E-7 7.265E-5 6.794E-4 1.380E-3 11 162
19 M2121 Genes correlated with classical type of glioblastoma multiforme tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.135E-7 7.265E-5 6.794E-4 1.380E-3 11 162
20 M15981 Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.951E-7 9.542E-5 8.923E-4 1.908E-3 17 430
21 M10150 Genes consistently down-regulated in ACRP cells (ovarian cancer, resistant to cisplatin [PubChem=2767]) compared to the parental sensitive A2780 cells, regardless of cisplatin exposure. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.737E-7 1.709E-4 1.599E-3 3.710E-3 6 35
22 M2781 Genes down-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 [Gene ID=648] gene by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 6.263E-7 1.709E-4 1.599E-3 4.050E-3 10 144
23 M5547 Age up-regulated genes in the human frontal cortex. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.297E-7 1.709E-4 1.599E-3 4.072E-3 13 262
24 M15835 Genes down-regulated SUM44/LCCTam cells (breast cancer) resistant to 4-hydroxytamoxifen [PubChem=63062] relative to the parental SUM44 cells sensitive to the drug. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.344E-7 1.709E-4 1.599E-3 4.103E-3 12 220
25 M2775 Genes down-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 and PCGF2 [Gene ID=648, 7703] genes by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 7.574E-7 1.959E-4 1.832E-3 4.898E-3 10 147
26 M2700 Genes down-regulated in bone relapse of breast cancer. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.340E-7 2.074E-4 1.940E-3 5.393E-3 14 314
27 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.269E-6 2.902E-4 2.714E-3 8.209E-3 16 425
28 M2882 Genes up-regulated in four lineages of epithelial cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v5.1) 1.327E-6 2.902E-4 2.714E-3 8.582E-3 13 280
29 M12138 Genes up-regulated in erythroid lineage cells by RUNX1-RUNX1T1 [GeneID=861;862] fusion . MSigDB C2: CGP Curated Gene Sets (v5.1) 1.383E-6 2.902E-4 2.714E-3 8.946E-3 10 157
30 M1610 All significantly up-regulated genes in kidney glomeruli isolated from TCF21 [Gene ID=6943] knockout mice. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.391E-6 2.902E-4 2.714E-3 8.996E-3 16 428
31 M1351 Genes down-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 48 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.391E-6 2.902E-4 2.714E-3 8.996E-3 16 428
32 M4299 Genes up-regulated in comparison of naive CD8 T cells versus effector CD8 IL2RA [GeneID=3559] high T cells at. MSigDB C7: Immunologic Signatures (v5.1) 1.734E-6 3.504E-4 3.277E-3 1.121E-2 11 200
33 M768 Genes commonly up-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.543E-6 4.984E-4 4.661E-3 1.645E-2 8 98
34 M4680 Genes up-regulated in RD cells (embryonal rhabdomyosarcoma, ERMS) by expression of PAX3- or PAX7-FOXO1 [GeneID=5077;5081;2308] fusions off retroviral vectors. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.978E-6 5.532E-4 5.173E-3 1.926E-2 12 255
35 M7363 Genes up-regulated in MCF7 cells (breast cancer) under hypoxia conditions. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.994E-6 5.532E-4 5.173E-3 1.936E-2 10 171
36 M2878 Genes up-regulated in four lineages of epithelial cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v5.1) 3.943E-6 7.083E-4 6.624E-3 2.550E-2 6 48
37 M6878 Genes down-regulated during B lymphocyte differentiation: large pre-B II versus VPREB1+ [GeneID=7441] pre-B Il. MSigDB C7: Immunologic Signatures (v5.1) 4.505E-6 7.874E-4 7.364E-3 2.913E-2 10 179
38 M2875 Genes up-regulated in four lineages of epithelial cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v5.1) 5.196E-6 8.659E-4 8.098E-3 3.361E-2 9 143
39 M8519 Genes down-regulated in mARMS (molecular ARMS) compared to the mERMS (molecular ERMS) class of rhabdomyosarcoma tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.222E-6 8.659E-4 8.098E-3 3.377E-2 10 182
40 M2256 Genes commonly down-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313 ,2078]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.877E-6 9.502E-4 8.886E-3 3.801E-2 11 227
41 M2506 Genes up-regulated in the neural crest stem cells (NCS), defined as p75+/HNK1+ [GeneID=4804;27087]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.157E-6 9.711E-4 9.082E-3 3.982E-2 9 146
42 M7061 Metastatic propensity markers of head and neck squamous cell carcinoma (HNSCC): up-regulated in metastatic vs non-metastatic tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.342E-6 9.765E-4 9.132E-3 4.101E-2 7 79
43 M19384 Genes up-regulated in mouse stroma of pancreatic adenocarcinoma zenografts after treatment with HhAntag, a hedgehog (Hh) pathway inhibitor. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.265E-6 1.093E-3 1.022E-2 4.698E-2 9 149
44 M1804 Genes up-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.736E-6 1.137E-3 1.063E-2
5.003E-2
 12 280
45 M988 Genes up-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371]. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.006E-6 1.289E-3 1.206E-2
5.824E-2
 9 153
46 M2726 Genes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] MCF-7 cells (breast cancer) stably over-expressing constitutively active RAF1 [Gene ID=5894] gene. MSigDB C6: Oncogenic Signatures (v5.1) 9.171E-6 1.289E-3 1.206E-2
5.931E-2
 10 194
47 M2633 Genes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] and engineered to express ligand-activatable EGFR [Gene ID=1956]. MSigDB C6: Oncogenic Signatures (v5.1) 1.003E-5 1.338E-3 1.251E-2
6.488E-2
 10 196
48 M2128 Genes up-regulated in growing IMR90 cells (fibroblast) after knockdown of RB1 [GeneID=5925] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.119E-5 1.338E-3 1.251E-2
7.234E-2
 11 243
49 M4510 Genes up-regulated in comparison of stimulated CD4 [GeneID=920] Th1 cells at 48 h versus stimulated CD4 [GeneID=920] Th2 cells at 48 h. MSigDB C7: Immunologic Signatures (v5.1) 1.146E-5 1.338E-3 1.251E-2
7.409E-2
 10 199
50 M6484 Genes up-regulated in monocyte-derived dendritic cells: untreated versus LPS and LPS like antigen from O. planktothrix (3h). MSigDB C7: Immunologic Signatures (v5.1) 1.146E-5 1.338E-3 1.251E-2
7.409E-2
 10 199
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 3320 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 OPC Top 500 All OPC Top 500 All Brain Map - Barres 3.187E-28 1.058E-24 9.191E-24 1.058E-24 42 494
2 80Dn SubClass 80Dn 5 Top 500 All 80Dn SubClass 80Dn 5 Top 500 All Brain Map - Allen iN 9.495E-27 1.051E-23 9.126E-23 3.152E-23 40 474
3 80Dn SubClass 80Dn 5 Top 500 Cluster 0 80Dn SubClass 80Dn 5 Top 500 Cluster 0 Brain Map - Allen iN 9.495E-27 1.051E-23 9.126E-23 3.152E-23 40 474
4 astrocytes Top 500 All astrocytes Top 500 All Brain Map - Barres 6.677E-24 5.542E-21 4.813E-20 2.217E-20 38 496
5 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 5.745E-23 3.814E-20 3.313E-19 1.907E-19 37 493
6 54Dp Top 500 Cluster 0 54Dp Top 500 Cluster 0 Brain Map - Allen iN 2.528E-17 1.199E-14 1.041E-13 8.393E-14 31 485
7 54Dp Top 500 All 54Dp Top 500 All Brain Map - Allen iN 2.528E-17 1.199E-14 1.041E-13 8.393E-14 31 485
8 80Dp Top 500 All 80Dp Top 500 All Brain Map - Allen iN 3.575E-17 1.484E-14 1.289E-13 1.187E-13 31 491
9 26Dn SubClass 26Dn 2 Top 500 All 26Dn SubClass 26Dn 2 Top 500 All Brain Map - Allen iN 4.338E-16 1.600E-13 1.390E-12 1.440E-12 30 498
10 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 500 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 9.837E-15 3.266E-12 2.837E-11 3.266E-11 27 441
11 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k4 1000 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.068E-14 6.242E-12 5.421E-11 6.866E-11 22 279
12 54Dn Top 500 Cluster 4 54Dn Top 500 Cluster 4 Brain Map - Allen iN 5.297E-14 1.466E-11 1.273E-10 1.759E-10 16 126
13 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k3 1000 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 6.133E-14 1.566E-11 1.360E-10 2.036E-10 19 203
14 Facebase ST1 e10.5 NeuroEpith CentrlOverEmin 250 e10.5 NeuroEpith CentrlOverEmin top-relative-expression-ranked 250 FaceBase_ST1 1.239E-13 2.894E-11 2.513E-10 4.115E-10 19 211
15 OPC Top 500 Cluster 3 OPC Top 500 Cluster 3 Brain Map - Barres 1.307E-13 2.894E-11 2.513E-10 4.341E-10 15 111
16 54Dp SubClass 54Dp 4 Top 500 All 54Dp SubClass 54Dp 4 Top 500 All Brain Map - Allen iN 4.499E-13 9.336E-11 8.109E-10 1.494E-9 26 476
17 Facebase RNAseq e10.5 Neural Epithelium Overlying Medial Eminence 500 FacebaseRNAseq e10.5 Neural Epithelium Overlying Medial Eminence top-relative-expression-ranked 500 FaceBase_RNAseq 5.993E-13 1.170E-10 1.017E-9 1.990E-9 26 482
18 PCBC ratio EB blastocyst vs EB bone marrow cfr-2X-p05 EB blastocyst vs EB bone marrow-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 2.162E-12 3.988E-10 3.463E-9 7.178E-9 22 351
19 OPC Top 500 Cluster 1 OPC Top 500 Cluster 1 Brain Map - Barres 2.680E-12 4.682E-10 4.067E-9 8.896E-9 10 40
20 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.814E-12 1.131E-9 9.824E-9 2.262E-8 22 372
21 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k1 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.200E-11 1.897E-9 1.648E-8 3.984E-8 14 125
22 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 500 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.472E-11 2.221E-9 1.929E-8 4.886E-8 23 427
23 astrocytes Top 500 Cluster 3 astrocytes Top 500 Cluster 3 Brain Map - Barres 1.938E-11 2.797E-9 2.429E-8 6.433E-8 9 34
24 54Dn SubClass 54Dn 4 Top 500 All 54Dn SubClass 54Dn 4 Top 500 All Brain Map - Allen iN 3.287E-11 4.547E-9 3.949E-8 1.091E-7 24 487
25 fetal quiescent Top 500 All fetal quiescent Top 500 All Brain Map - Barres 3.578E-11 4.751E-9 4.127E-8 1.188E-7 24 489
26 Facebase ST1 e10.5 NeuroEpith CentrlOverEmin 500 e10.5 NeuroEpith CentrlOverEmin top-relative-expression-ranked 500 FaceBase_ST1 4.743E-11 6.056E-9 5.260E-8 1.575E-7 22 411
27 Lungmap Mouse e16.5 Myofibro Top 500 All Lungmap Mouse e16.5 Myofibro Top 500 All Lungmap Mouse Single Cell (Lungmap.net) 7.193E-11 8.844E-9 7.681E-8 2.388E-7 22 420
28 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 500 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.244E-11 9.775E-9 8.490E-8 2.737E-7 22 423
29 Facebase RNAseq e10.5 Neural Epithelium Overlying Lateral Eminence 500 K4 FacebaseRNAseq e10.5 Neural Epithelium Overlying Lateral Eminence top-relative-expression-ranked 500 k-means-cluster#4 FaceBase_RNAseq 1.128E-10 1.292E-8 1.122E-7 3.746E-7 13 121
30 Facebase RNAseq e10.5 Neural Epithelium Overlying Medial Eminence 2500 K5 FacebaseRNAseq e10.5 Neural Epithelium Overlying Medial Eminence top-relative-expression-ranked 2500 k-means-cluster#5 FaceBase_RNAseq 1.199E-10 1.327E-8 1.152E-7 3.980E-7 20 350
31 54SK Top 500 All 54SK Top 500 All Brain Map - Allen iN 2.098E-10 2.246E-8 1.951E-7 6.964E-7 23 488
32 80Dn Top 500 Cluster 0 80Dn Top 500 Cluster 0 Brain Map - Allen iN 2.416E-10 2.507E-8 2.177E-7 8.022E-7 9 44
33 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 2.664E-10 2.681E-8 2.328E-7 8.846E-7 23 494
34 Facebase RNAseq e10.5 Neural Epithelium Overlying Central Eminence 500 FacebaseRNAseq e10.5 Neural Epithelium Overlying Central Eminence top-relative-expression-ranked 500 FaceBase_RNAseq 2.999E-10 2.928E-8 2.543E-7 9.957E-7 23 497
35 Facebase RNAseq e10.5 Neural Epithelium Flanking Eminence 500 FacebaseRNAseq e10.5 Neural Epithelium Flanking Eminence top-relative-expression-ranked 500 FaceBase_RNAseq 3.119E-10 2.959E-8 2.570E-7 1.036E-6 23 498
36 Facebase ST1 e10.5 NeuroEpith CentrlOverEmin 100 e10.5 NeuroEpith CentrlOverEmin top-relative-expression-ranked 100 FaceBase_ST1 3.672E-10 3.386E-8 2.941E-7 1.219E-6 11 84
37 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 200 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 4.457E-10 3.999E-8 3.473E-7 1.480E-6 15 194
38 OPC Top 500 Cluster 4 OPC Top 500 Cluster 4 Brain Map - Barres 6.726E-10 5.876E-8 5.104E-7 2.233E-6 9 49
39 Facebase ST1 e10.5 NeuroEpith FlankLateral 500 e10.5 NeuroEpith FlankLateral top-relative-expression-ranked 500 FaceBase_ST1 9.974E-10 8.491E-8 7.374E-7 3.311E-6 20 395
40 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 1.320E-9 1.096E-7 9.515E-7 4.382E-6 21 445
41 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k1 1000 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.432E-9 1.160E-7 1.007E-6 4.755E-6 15 211
42 Facebase RNAseq e10.5 Neural Epithelium Overlying Lateral Eminence 500 FacebaseRNAseq e10.5 Neural Epithelium Overlying Lateral Eminence top-relative-expression-ranked 500 FaceBase_RNAseq 1.531E-9 1.182E-7 1.026E-6 5.082E-6 22 494
43 neurons Top 500 All neurons Top 500 All Brain Map - Barres 1.531E-9 1.182E-7 1.026E-6 5.082E-6 22 494
44 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 500 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.743E-9 1.306E-7 1.134E-6 5.786E-6 20 408
45 Facebase RNAseq e10.5 Neural Epithelium Flanking Eminence 500 K4 FacebaseRNAseq e10.5 Neural Epithelium Flanking Eminence top-relative-expression-ranked 500 k-means-cluster#4 FaceBase_RNAseq 1.770E-9 1.306E-7 1.134E-6 5.875E-6 11 97
46 54Dp SubClass 54Dp 5 Top 500 All 54Dp SubClass 54Dp 5 Top 500 All Brain Map - Allen iN 2.383E-9 1.701E-7 1.477E-6 7.911E-6 21 460
47 Facebase RNAseq e10.5 Neural Epithelium Flanking Eminence 100 FacebaseRNAseq e10.5 Neural Epithelium Flanking Eminence top-relative-expression-ranked 100 FaceBase_RNAseq 2.459E-9 1.701E-7 1.477E-6 8.164E-6 11 100
48 Facebase RNAseq e10.5 Neural Epithelium Overlying Lateral Eminence 100 FacebaseRNAseq e10.5 Neural Epithelium Overlying Lateral Eminence top-relative-expression-ranked 100 FaceBase_RNAseq 2.459E-9 1.701E-7 1.477E-6 8.164E-6 11 100
49 Arv EB-LF 500 K2 AravindRamakr EmbryoidBody-LF top-relative-expression-ranked 500 k-means-cluster#2 PCBC 2.597E-9 1.760E-7 1.528E-6 8.622E-6 16 256
50 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 1000 k2 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.886E-9 1.916E-7 1.664E-6 9.582E-6 19 377
Show 45 more annotations

15: Computational [Display Chart] 417 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 7.116E-22 2.967E-19 1.962E-18 2.967E-19 37 351
2 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 1.647E-7 3.435E-5 2.271E-4 6.870E-5 21 378
3 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 2.454E-5 3.411E-3 2.255E-2 1.023E-2 17 361
4 GCM AQP4 Neighborhood of AQP4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.347E-5 3.936E-3 2.603E-2 1.813E-2 6 44
5 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 4.720E-5 3.936E-3 2.603E-2 1.968E-2 18 419
6 GNF2 MAPT Neighborhood of MAPT MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.307E-4 1.603E-2
1.060E-1
9.620E-2
 5 38
7 module 8 Genes in module 8 MSigDb: C4 - CM: Cancer Modules 3.419E-4 2.037E-2
1.347E-1
1.426E-1
 16 406
8 module 19 Genes in module 19 MSigDb: C4 - CM: Cancer Modules 6.472E-4 3.373E-2
2.230E-1
2.699E-1
 13 307
Show 3 more annotations

16: MicroRNA [Display Chart] 1343 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-216b:PITA hsa-miR-216b:PITA TOP PITA 3.700E-8 4.970E-5 3.866E-4 4.970E-5 17 338
2 hsa-miR-516a-3p:PITA hsa-miR-516a-3p:PITA TOP PITA 1.655E-7 1.112E-4 8.649E-4 2.223E-4 13 212
3 GACTGTT,MIR-132:MSigDB GACTGTT,MIR-132:MSigDB MSigDB 3.320E-7 1.115E-4 8.673E-4 4.459E-4 11 154
4 GACTGTT,MIR-212:MSigDB GACTGTT,MIR-212:MSigDB MSigDB 3.320E-7 1.115E-4 8.673E-4 4.459E-4 11 154
5 hsa-miR-1284:PITA hsa-miR-1284:PITA TOP PITA 1.009E-6 2.711E-4 2.110E-3 1.356E-3 17 427
6 miR-367:PicTar miR-367:PicTar PicTar 5.603E-6 1.254E-3 9.757E-3 7.524E-3 14 336
7 hsa-miR-499-5p:PITA hsa-miR-499-5p:PITA TOP PITA 1.276E-5 2.447E-3 1.904E-2 1.713E-2 11 224
8 hsa-miR-1826:PITA hsa-miR-1826:PITA TOP PITA 2.395E-5 3.164E-3 2.462E-2 3.216E-2 10 197
9 hsa-miR-1236:PITA hsa-miR-1236:PITA TOP PITA 2.422E-5 3.164E-3 2.462E-2 3.253E-2 11 240
10 hsa-miR-579:PITA hsa-miR-579:PITA TOP PITA 2.451E-5 3.164E-3 2.462E-2 3.291E-2 15 435
11 hsa-miR-212:PITA hsa-miR-212:PITA TOP PITA 2.827E-5 3.164E-3 2.462E-2 3.797E-2 13 338
12 hsa-miR-132:PITA hsa-miR-132:PITA TOP PITA 2.827E-5 3.164E-3 2.462E-2 3.797E-2 13 338
13 hsa-miR-602:PITA hsa-miR-602:PITA TOP PITA 3.196E-5 3.301E-3 2.568E-2 4.292E-2 5 38
14 hsa-miR-146b-5p:PITA hsa-miR-146b-5p:PITA TOP PITA 4.640E-5 4.017E-3 3.125E-2
6.231E-2
 9 171
15 hsa-miR-146a:PITA hsa-miR-146a:PITA TOP PITA 4.640E-5 4.017E-3 3.125E-2
6.231E-2
 9 171
16 hsa-miR-653:PITA hsa-miR-653:PITA TOP PITA 4.785E-5 4.017E-3 3.125E-2
6.427E-2
 12 306
17 hsa-miR-514:PITA hsa-miR-514:PITA TOP PITA 5.554E-5 4.387E-3 3.413E-2
7.459E-2
 9 175
18 hsa-miR-139-5p:PITA hsa-miR-139-5p:PITA TOP PITA 7.130E-5 5.320E-3 4.139E-2
9.576E-2
 12 319
19 hsa-miR-140-3p:PITA hsa-miR-140-3p:PITA TOP PITA 9.554E-5 6.420E-3 4.995E-2
1.283E-1
 12 329
20 hsa-miR-18a:TargetScan hsa-miR-18a:TargetScan TargetScan 1.004E-4 6.420E-3 4.995E-2
1.348E-1
 9 189
21 hsa-miR-18b:TargetScan hsa-miR-18b:TargetScan TargetScan 1.004E-4 6.420E-3 4.995E-2
1.348E-1
 9 189
22 hsa-miR-1248:PITA hsa-miR-1248:PITA TOP PITA 1.133E-4 6.914E-3
5.379E-2
1.521E-1
 10 237
23 hsa-miR-452:PITA hsa-miR-452:PITA TOP PITA 1.401E-4 7.675E-3
5.971E-2
1.881E-1
 14 451
24 miR-136:PicTar miR-136:PicTar PicTar 1.409E-4 7.675E-3
5.971E-2
1.892E-1
 7 116
25 hsa-miR-1183:PITA hsa-miR-1183:PITA TOP PITA 1.429E-4 7.675E-3
5.971E-2
1.919E-1
 9 198
26 hsa-miR-145:PITA hsa-miR-145:PITA TOP PITA 1.590E-4 8.214E-3
6.391E-2
2.136E-1
 13 401
27 hsa-miR-1290:PITA hsa-miR-1290:PITA TOP PITA 1.843E-4 8.249E-3
6.418E-2
2.475E-1
 12 353
28 hsa-miR-421:PITA hsa-miR-421:PITA TOP PITA 1.941E-4 8.249E-3
6.418E-2
2.607E-1
 12 355
29 hsa-miR-520c-5p:PITA hsa-miR-520c-5p:PITA TOP PITA 2.027E-4 8.249E-3
6.418E-2
2.722E-1
 7 123
30 hsa-miR-519b-5p:PITA hsa-miR-519b-5p:PITA TOP PITA 2.027E-4 8.249E-3
6.418E-2
2.722E-1
 7 123
31 hsa-miR-526a:PITA hsa-miR-526a:PITA TOP PITA 2.027E-4 8.249E-3
6.418E-2
2.722E-1
 7 123
32 hsa-miR-519c-5p:PITA hsa-miR-519c-5p:PITA TOP PITA 2.027E-4 8.249E-3
6.418E-2
2.722E-1
 7 123
33 hsa-miR-518d-5p:PITA hsa-miR-518d-5p:PITA TOP PITA 2.027E-4 8.249E-3
6.418E-2
2.722E-1
 7 123
34 hsa-miR-455-3p:PITA hsa-miR-455-3p:PITA TOP PITA 2.120E-4 8.375E-3
6.516E-2
2.847E-1
 10 256
35 hsa-miR-1303:PITA hsa-miR-1303:PITA TOP PITA 2.328E-4 8.418E-3
6.549E-2
3.127E-1
 10 259
36 TTTGTAG,MIR-520D:MSigDB TTTGTAG,MIR-520D:MSigDB MSigDB 2.370E-4 8.418E-3
6.549E-2
3.183E-1
 11 310
37 miR-132:PicTar miR-132:PicTar PicTar 2.382E-4 8.418E-3
6.549E-2
3.199E-1
 9 212
38 miR-212:PicTar miR-212:PicTar PicTar 2.382E-4 8.418E-3
6.549E-2
3.199E-1
 9 212
39 TGGTGCT,MIR-29B:MSigDB TGGTGCT,MIR-29B:MSigDB MSigDB 2.656E-4 8.477E-3
6.596E-2
3.566E-1
 14 480
40 TGGTGCT,MIR-29A:MSigDB TGGTGCT,MIR-29A:MSigDB MSigDB 2.656E-4 8.477E-3
6.596E-2
3.566E-1
 14 480
41 TGGTGCT,MIR-29C:MSigDB TGGTGCT,MIR-29C:MSigDB MSigDB 2.656E-4 8.477E-3
6.596E-2
3.566E-1
 14 480
42 hsa-miR-571:PITA hsa-miR-571:PITA TOP PITA 2.791E-4 8.477E-3
6.596E-2
3.748E-1
 6 92
43 hsa-miR-539:PITA hsa-miR-539:PITA TOP PITA 2.828E-4 8.477E-3
6.596E-2
3.799E-1
 14 483
44 hsa-miR-146a:TargetScan hsa-miR-146a:TargetScan TargetScan 2.848E-4 8.477E-3
6.596E-2
3.824E-1
 7 130
45 hsa-miR-146b-5p:TargetScan hsa-miR-146b-5p:TargetScan TargetScan 2.848E-4 8.477E-3
6.596E-2
3.824E-1
 7 130
46 hsa-miR-1252:PITA hsa-miR-1252:PITA TOP PITA 2.904E-4 8.477E-3
6.596E-2
3.900E-1
 12 371
47 hsa-miR-34b:PITA hsa-miR-34b:PITA TOP PITA 3.520E-4 1.006E-2
7.826E-2
4.728E-1
 12 379
48 miR-218:PicTar miR-218:PicTar PicTar 3.810E-4 1.066E-2
8.293E-2
5.117E-1
 13 439
49 hsa-miR-383:PITA hsa-miR-383:PITA TOP PITA 3.917E-4 1.073E-2
8.352E-2
5.260E-1
 7 137
50 miR-181c:PicTar miR-181c:PicTar PicTar 4.003E-4 1.075E-2
8.365E-2
5.375E-1
 14 500
Show 45 more annotations

17: Drug [Display Chart] 21726 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 D010656 Phenylephrine CTD 6.066E-10 1.318E-5 1.392E-4 1.318E-5 22 500
2 C009618 O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate CTD 2.750E-8 2.987E-4 3.155E-3 5.974E-4 13 201
3 3124 UP Remoxipride Hydrochloride [73220-03-8]; Up 200; 9.8uM; HL60; HT HG-U133A Broad Institute CMAP 1.643E-7 7.546E-4 7.971E-3 3.569E-3 12 195
4 4314 DN Fluocinonide [356-12-7]; Down 200; 8uM; PC3; HT HG-U133A Broad Institute CMAP 1.737E-7 7.546E-4 7.971E-3 3.773E-3 12 196
5 4746 UP Hydralazine hydrochloride [304-20-1]; Up 200; 20.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.737E-7 7.546E-4 7.971E-3 3.773E-3 12 196
6 CID003016733 1-hydroxypyrazole Stitch 3.922E-7 1.065E-3 1.125E-2 8.521E-3 4 8
7 CID003614351 1-hydroxyimidazole Stitch 3.922E-7 1.065E-3 1.125E-2 8.521E-3 4 8
8 CID000127037 2,3-PDCA Stitch 3.922E-7 1.065E-3 1.125E-2 8.521E-3 4 8
9 CID000024766 chondroitin sulfate Stitch 8.163E-7 1.971E-3 2.082E-2 1.774E-2 16 413
10 C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone CTD 9.825E-7 1.993E-3 2.105E-2 2.135E-2 14 320
11 CID000000966 oleoyl coenzyme A Stitch 1.009E-6 1.993E-3 2.105E-2 2.192E-2 9 118
12 4366 UP Ethotoin [86-35-1]; Up 200; 19.6uM; MCF7; HT HG-U133A Broad Institute CMAP 1.287E-6 2.320E-3 2.451E-2 2.797E-2 11 195
13 6423 UP C75; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.423E-6 2.320E-3 2.451E-2 3.091E-2 11 197
14 5865 UP Atropine sulfate monohydrate [5908-99-6]; Up 200; 5.8uM; PC3; HT HG-U133A Broad Institute CMAP 1.495E-6 2.320E-3 2.451E-2 3.248E-2 11 198
15 5601 UP estradiol, USP; Up 200; 0.01uM; MCF7; HT HG-U133A Broad Institute CMAP 1.650E-6 2.389E-3 2.524E-2 3.584E-2 11 200
16 6149 UP (-)-Isoproterenol hydrochloride [5984-95-2]; Up 200; 16.2uM; HL60; HT HG-U133A Broad Institute CMAP 1.962E-6 2.570E-3 2.714E-2 4.263E-2 10 164
17 CID000003816 NSC759587 Stitch 2.093E-6 2.570E-3 2.714E-2 4.548E-2 16 444
18 C038939 enzacamene CTD 2.129E-6 2.570E-3 2.714E-2 4.625E-2 9 129
19 C118580 octylmethoxycinnamate CTD 2.419E-6 2.766E-3 2.922E-2
5.256E-2
 9 131
20 CID004489307 AC1NB8R3 Stitch 3.040E-6 3.302E-3 3.488E-2
6.605E-2
 11 213
21 4565 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 3.702E-6 3.655E-3 3.861E-2
8.042E-2
 10 176
22 2926 UP Zardaverine [101975-10-4]; Up 200; 15uM; HL60; HT HG-U133A Broad Institute CMAP 3.702E-6 3.655E-3 3.861E-2
8.042E-2
 10 176
23 D003345 Corticosterone CTD 3.881E-6 3.666E-3 3.873E-2
8.432E-2
 12 263
24 C487081 belinostat CTD 4.503E-6 4.077E-3 4.306E-2
9.784E-2
 15 417
25 C506614 PD 0325901 CTD 5.080E-6 4.245E-3 4.484E-2
1.104E-1
 8 108
26 D008044 Linuron CTD 5.080E-6 4.245E-3 4.484E-2
1.104E-1
 8 108
27 C038091 butylparaben CTD 5.276E-6 4.245E-3 4.484E-2
1.146E-1
 9 144
28 CID004476950 Nchembio861-comp5 Stitch 6.165E-6 4.784E-3
5.054E-2
1.340E-1
 6 52
29 4455 DN 15d-PGJ2; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 8.767E-6 5.949E-3
6.285E-2
1.905E-1
 10 194
30 2086 UP Ampyrone [83-07-8]; Up 200; 19.6uM; PC3; HT HG-U133A Broad Institute CMAP 9.591E-6 5.949E-3
6.285E-2
2.084E-1
 10 196
31 CID000005442 Granosan M Stitch 9.650E-6 5.949E-3
6.285E-2
2.097E-1
 4 16
32 2869 UP Chloroquine diphosphate [50-63-5]; Up 200; 7.8uM; MCF7; HT HG-U133A Broad Institute CMAP 1.003E-5 5.949E-3
6.285E-2
2.179E-1
 10 197
33 6810 UP Sulfanilamide [63-74-1]; Up 200; 23.2uM; MCF7; HT HG-U133A Broad Institute CMAP 1.003E-5 5.949E-3
6.285E-2
2.179E-1
 10 197
34 5974 DN PF-00539745-00 [351321-33-0]; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.003E-5 5.949E-3
6.285E-2
2.179E-1
 10 197
35 6694 DN Loxapine succinate [27833-64-3]; Down 200; 9uM; PC3; HT HG-U133A Broad Institute CMAP 1.003E-5 5.949E-3
6.285E-2
2.179E-1
 10 197
36 6097 UP Isopyrin hydrochloride [18342-39-7]; Up 200; 14.2uM; MCF7; HT HG-U133A Broad Institute CMAP 1.048E-5 5.949E-3
6.285E-2
2.277E-1
 10 198
37 3727 DN Prilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; PC3; HT HG-U133A Broad Institute CMAP 1.048E-5 5.949E-3
6.285E-2
2.277E-1
 10 198
38 3546 UP Leucomisine [17946-87-1]; Up 200; 16.2uM; MCF7; HT HG-U133A Broad Institute CMAP 1.095E-5 5.949E-3
6.285E-2
2.380E-1
 10 199
39 7494 DN 15(S)-15-methyl Prostaglandin E2; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 1.095E-5 5.949E-3
6.285E-2
2.380E-1
 10 199
40 2367 UP Vincamine [1617-90-9]; Up 200; 11.2uM; HL60; HT HG-U133A Broad Institute CMAP 1.095E-5 5.949E-3
6.285E-2
2.380E-1
 10 199
41 6405 UP PF-01378883-00 [351320-41-7]; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.144E-5 6.064E-3
6.405E-2
2.486E-1
 10 200
42 CID000005281 stearic acid Stitch 1.178E-5 6.095E-3
6.438E-2
2.560E-1
 9 159
43 CID000006238 17-hydroxyprogesterone Stitch 1.329E-5 6.714E-3
7.092E-2
2.887E-1
 8 123
44 1793 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.919E-5 9.475E-3
1.001E-1
4.169E-1
 9 169
45 CID000005917 pentylenetetrazol Stitch 1.989E-5 9.603E-3
1.014E-1
4.321E-1
 8 130
46 2723 UP Cycloheximide [66-81-9]; Up 200; 14.2uM; HL60; HT HG-U133A Broad Institute CMAP 2.107E-5 9.950E-3
1.051E-1
4.577E-1
 9 171
47 CID000018845 iduronic acid Stitch 2.223E-5 1.028E-2
1.086E-1
4.830E-1
 7 96
48 CID000121630 4,4-dimethyloxazoline Stitch 2.272E-5 1.028E-2
1.086E-1
4.936E-1
 3 7
49 CID000005070 riluzole Stitch 2.418E-5 1.030E-2
1.088E-1
5.253E-1
 9 174
50 2084 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 2.418E-5 1.030E-2
1.088E-1
5.253E-1
 9 174
Show 45 more annotations

18: Disease [Display Chart] 2192 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0206727 Nerve Sheath Tumors DisGeNET Curated 5.583E-7 1.087E-3 8.992E-3 1.224E-3 7 47
2 umls:C0027830 neurofibroma DisGeNET Curated 9.920E-7 1.087E-3 8.992E-3 2.175E-3 7 51
3 umls:C0024667 Animal Mammary Neoplasms DisGeNET Curated 1.540E-5 7.733E-3
6.395E-2
 3.376E-2 9 138
4 umls:C0014474 Ependymoma DisGeNET Curated 1.841E-5 7.733E-3
6.395E-2
 4.035E-2 8 108
5 umls:C0040517 Gilles de la Tourette syndrome DisGeNET Curated 2.107E-5 7.733E-3
6.395E-2
 4.619E-2 7 80
6 umls:C0750974 Brain Tumor, Primary DisGeNET BeFree 2.117E-5 7.733E-3
6.395E-2
 4.640E-2 6 54
7 umls:C0024668 Mammary Neoplasms, Experimental DisGeNET Curated 3.323E-5 1.041E-2
8.606E-2
7.285E-2
 9 152
8 umls:C0206663 Neuroectodermal Tumor, Primitive DisGeNET Curated 4.712E-5 1.291E-2
1.068E-1
1.033E-1
 8 123
9 umls:C0279000 Liver and Intrahepatic Biliary Tract Carcinoma DisGeNET BeFree 7.139E-5 1.739E-2
1.438E-1
1.565E-1
 16 496
10 106300 SPONDYLOARTHROPATHY, SUSCEPTIBILITY TO, 1; SPDA1 OMIM 1.102E-4 1.857E-2
1.536E-1
2.415E-1
 2 2
11 umls:C0264652 Hypertensive heart failure DisGeNET BeFree 1.102E-4 1.857E-2
1.536E-1
2.415E-1
 2 2
12 608579 SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO OMIM 1.102E-4 1.857E-2
1.536E-1
2.415E-1
 2 2
13 cv:C1840548 Susceptibility to severe cutaneous adverse reaction Clinical Variations 1.102E-4 1.857E-2
1.536E-1
2.415E-1
 2 2
14 umls:C0003469 Anxiety Disorders DisGeNET Curated 1.552E-4 2.430E-2
2.009E-1
3.401E-1
 13 371
15 umls:C0278883 Metastatic melanoma DisGeNET BeFree 2.158E-4 3.153E-2
2.607E-1
4.729E-1
 12 333
16 umls:C0006111 Brain Diseases DisGeNET Curated 2.637E-4 3.597E-2
2.975E-1
5.781E-1
 7 119
17 umls:C0008074 Child Development Disorders, Pervasive DisGeNET Curated 3.016E-4 3.597E-2
2.975E-1
6.611E-1
 5 56
18 umls:C0004936 Mental disorders DisGeNET Curated 3.060E-4 3.597E-2
2.975E-1
6.709E-1
 12 346
19 umls:C2350168 Polymorphic Reticulosis DisGeNET BeFree 3.282E-4 3.597E-2
2.975E-1
7.194E-1
 2 3
20 umls:C0338986 Atypical autism DisGeNET BeFree 3.282E-4 3.597E-2
2.975E-1
7.194E-1
 2 3
21 umls:C0041696 Unipolar Depression DisGeNET BeFree 3.629E-4 3.788E-2
3.133E-1
7.956E-1
 13 405
22 umls:C1334177 Infiltrating Cervical Carcinoma DisGeNET BeFree 4.503E-4 4.291E-2
3.549E-1
9.870E-1
 5 61
23 umls:C1514422 Primary Glioblastoma DisGeNET BeFree 4.503E-4 4.291E-2
3.549E-1
9.870E-1
 5 61
24 umls:C0027439 Nasopharyngeal Neoplasms DisGeNET Curated 4.751E-4 4.339E-2
3.588E-1
1.000E0
 3 15
25 umls:C0028945 oligodendroglioma DisGeNET Curated 5.152E-4 4.517E-2
3.736E-1
1.000E0
 8 174
26 umls:C0205748 Dysplastic Nevus DisGeNET BeFree 5.626E-4 4.743E-2
3.923E-1
1.000E0
 5 64
27 umls:C0334579 Anaplastic astrocytoma DisGeNET Curated 6.184E-4 4.927E-2
4.075E-1
1.000E0
 7 137
28 umls:C0175708 Chronic rheumatic heart disease DisGeNET BeFree 6.518E-4 4.927E-2
4.075E-1
1.000E0
 2 4
29 umls:C0042167 Uveitis, Posterior DisGeNET BeFree 6.518E-4 4.927E-2
4.075E-1
1.000E0
 2 4
Show 24 more annotations