Toppgene analysis for aggregated_1964_log, IC23, positive side

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1: GO: Molecular Function [Display Chart] 611 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0015631 tubulin binding 5.218E-5 2.873E-2
2.009E-1
 3.188E-2 13 293
2 GO:0001105 RNA polymerase II transcription coactivator activity 1.208E-4 2.873E-2
2.009E-1
7.379E-2
 5 41
3 GO:0046899 nucleoside triphosphate adenylate kinase activity 1.411E-4 2.873E-2
2.009E-1
8.618E-2
 2 2
4 GO:0008017 microtubule binding 2.536E-4 3.505E-2
2.451E-1
1.550E-1
 10 214
5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding 2.869E-4 3.505E-2
2.451E-1
1.753E-1
 11 259
6 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding 4.528E-4 4.612E-2
3.225E-1
2.767E-1
 13 365
7 GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding 6.782E-4 4.624E-2
3.234E-1
4.144E-1
 5 59
8 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding 6.782E-4 4.624E-2
3.234E-1
4.144E-1
 5 59
9 GO:0015643 toxic substance binding 6.811E-4 4.624E-2
3.234E-1
4.162E-1
 3 15
10 GO:0032051 clathrin light chain binding 8.331E-4 4.757E-2
3.327E-1
5.090E-1
 2 4
11 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding 8.565E-4 4.757E-2
3.327E-1
5.233E-1
 6 93
Show 6 more annotations

2: GO: Biological Process [Display Chart] 3654 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007409 axonogenesis 2.154E-12 7.870E-9 6.910E-8 7.870E-9 28 478
2 GO:0010975 regulation of neuron projection development 7.702E-10 1.407E-6 1.236E-5 2.814E-6 25 494
3 GO:0060052 neurofilament cytoskeleton organization 4.944E-8 6.022E-5 5.288E-4 1.807E-4 5 10
4 GO:0021955 central nervous system neuron axonogenesis 1.095E-7 1.000E-4 8.782E-4 4.001E-4 7 34
5 GO:0007411 axon guidance 1.599E-7 1.027E-4 9.020E-4 5.841E-4 15 241
6 GO:0097485 neuron projection guidance 1.687E-7 1.027E-4 9.020E-4 6.164E-4 15 242
7 GO:0048485 sympathetic nervous system development 2.005E-7 1.047E-4 9.192E-4 7.328E-4 6 23
8 GO:0048588 developmental cell growth 3.565E-7 1.628E-4 1.430E-3 1.303E-3 14 222
9 GO:0021953 central nervous system neuron differentiation 7.077E-7 2.606E-4 2.289E-3 2.586E-3 13 201
10 GO:0021954 central nervous system neuron development 7.133E-7 2.606E-4 2.289E-3 2.606E-3 9 86
11 GO:0048483 autonomic nervous system development 8.284E-7 2.752E-4 2.416E-3 3.027E-3 7 45
12 GO:0060560 developmental growth involved in morphogenesis 1.007E-6 2.852E-4 2.505E-3 3.678E-3 14 242
13 GO:0010721 negative regulation of cell development 1.015E-6 2.852E-4 2.505E-3 3.708E-3 17 356
14 GO:0033693 neurofilament bundle assembly 1.563E-6 4.080E-4 3.582E-3 5.712E-3 3 3
15 GO:0023061 signal release 1.711E-6 4.168E-4 3.660E-3 6.252E-3 20 499
16 GO:0001667 ameboidal-type cell migration 3.343E-6 7.636E-4 6.705E-3 1.222E-2 16 347
17 GO:0050768 negative regulation of neurogenesis 7.351E-6 1.536E-3 1.349E-2 2.686E-2 14 287
18 GO:0006836 neurotransmitter transport 7.566E-6 1.536E-3 1.349E-2 2.765E-2 12 212
19 GO:0099504 synaptic vesicle cycle 1.317E-5 2.533E-3 2.224E-2 4.813E-2 9 122
20 GO:0030073 insulin secretion 1.793E-5 3.159E-3 2.774E-2
6.553E-2
 12 231
21 GO:0051961 negative regulation of nervous system development 1.816E-5 3.159E-3 2.774E-2
6.634E-2
 14 311
22 GO:0045104 intermediate filament cytoskeleton organization 1.912E-5 3.175E-3 2.788E-2
6.986E-2
 6 48
23 GO:0045103 intermediate filament-based process 2.158E-5 3.428E-3 3.010E-2
7.884E-2
 6 49
24 GO:1990138 neuron projection extension 2.715E-5 4.134E-3 3.630E-2
9.921E-2
 10 167
25 GO:0045110 intermediate filament bundle assembly 3.046E-5 4.452E-3 3.909E-2
1.113E-1
 3 6
26 GO:0099531 presynaptic process involved in chemical synaptic transmission 3.673E-5 5.162E-3 4.532E-2
1.342E-1
 10 173
27 GO:0001505 regulation of neurotransmitter levels 4.619E-5 6.095E-3
5.352E-2
1.688E-1
 11 215
28 GO:0001755 neural crest cell migration 4.681E-5 6.095E-3
5.352E-2
1.710E-1
 6 56
29 GO:0003215 cardiac right ventricle morphogenesis 4.837E-5 6.095E-3
5.352E-2
1.768E-1
 4 18
30 GO:0003357 noradrenergic neuron differentiation 5.285E-5 6.437E-3
5.652E-2
1.931E-1
 3 7
31 GO:0014033 neural crest cell differentiation 5.629E-5 6.635E-3
5.826E-2
2.057E-1
 7 84
32 GO:0045665 negative regulation of neuron differentiation 7.841E-5 8.953E-3
7.862E-2
2.865E-1
 11 228
33 GO:0046879 hormone secretion 8.380E-5 9.279E-3
8.148E-2
3.062E-1
 14 358
34 GO:0007626 locomotory behavior 9.882E-5 1.052E-2
9.237E-2
3.611E-1
 11 234
35 GO:0050796 regulation of insulin secretion 1.092E-4 1.052E-2
9.237E-2
3.991E-1
 10 197
36 GO:0031290 retinal ganglion cell axon guidance 1.115E-4 1.052E-2
9.237E-2
4.074E-1
 4 22
37 GO:0051216 cartilage development 1.139E-4 1.052E-2
9.237E-2
4.162E-1
 10 198
38 GO:0001764 neuron migration 1.165E-4 1.052E-2
9.237E-2
4.257E-1
 9 161
39 GO:0009914 hormone transport 1.220E-4 1.052E-2
9.237E-2
4.459E-1
 14 371
40 GO:0050678 regulation of epithelial cell proliferation 1.239E-4 1.052E-2
9.237E-2
4.526E-1
 13 326
41 GO:0030072 peptide hormone secretion 1.275E-4 1.052E-2
9.237E-2
4.660E-1
 12 283
42 GO:0007269 neurotransmitter secretion 1.280E-4 1.052E-2
9.237E-2
4.677E-1
 9 163
43 GO:0099643 signal release from synapse 1.280E-4 1.052E-2
9.237E-2
4.677E-1
 9 163
44 GO:0043542 endothelial cell migration 1.341E-4 1.052E-2
9.237E-2
4.899E-1
 9 164
45 GO:2000791 negative regulation of mesenchymal cell proliferation involved in lung development 1.353E-4 1.052E-2
9.237E-2
4.944E-1
 2 2
46 GO:2000790 regulation of mesenchymal cell proliferation involved in lung development 1.353E-4 1.052E-2
9.237E-2
4.944E-1
 2 2
47 GO:2000707 positive regulation of dense core granule biogenesis 1.353E-4 1.052E-2
9.237E-2
4.944E-1
 2 2
48 GO:0045666 positive regulation of neuron differentiation 1.443E-4 1.098E-2
9.642E-2
5.271E-1
 14 377
49 GO:0048675 axon extension 1.603E-4 1.196E-2
1.050E-1
5.859E-1
 8 132
50 GO:0002790 peptide secretion 1.654E-4 1.209E-2
1.061E-1
6.043E-1
 12 291
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 351 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0098794 postsynapse 7.696E-10 2.701E-7 1.740E-6 2.701E-7 24 454
2 GO:0060076 excitatory synapse 1.043E-8 1.831E-6 1.179E-5 3.662E-6 17 258
3 GO:0014069 postsynaptic density 2.163E-8 1.898E-6 1.222E-5 7.592E-6 16 238
4 GO:0099572 postsynaptic specialization 2.163E-8 1.898E-6 1.222E-5 7.592E-6 16 238
5 GO:0005883 neurofilament 5.003E-8 3.512E-6 2.262E-5 1.756E-5 5 10
6 GO:0097060 synaptic membrane 9.498E-8 5.556E-6 3.578E-5 3.334E-5 17 300
7 GO:0008021 synaptic vesicle 1.538E-5 7.712E-4 4.966E-3 5.399E-3 10 156
8 GO:0031968 organelle outer membrane 2.118E-5 9.291E-4 5.983E-3 7.433E-3 11 197
9 GO:0019867 outer membrane 2.924E-5 1.026E-3 6.610E-3 1.026E-2 11 204
10 GO:0043209 myelin sheath 2.924E-5 1.026E-3 6.610E-3 1.026E-2 11 204
11 GO:0070382 exocytic vesicle 3.571E-5 1.139E-3 7.337E-3 1.253E-2 10 172
12 GO:0098793 presynapse 5.123E-5 1.499E-3 9.650E-3 1.798E-2 14 341
13 GO:0045211 postsynaptic membrane 7.124E-5 1.864E-3 1.200E-2 2.500E-2 11 225
14 GO:0033267 axon part 7.435E-5 1.864E-3 1.200E-2 2.610E-2 13 309
15 GO:0005741 mitochondrial outer membrane 1.956E-4 4.577E-3 2.947E-2
6.865E-2
 9 172
16 GO:0030426 growth cone 2.977E-4 6.532E-3 4.206E-2
1.045E-1
 9 182
17 GO:0030427 site of polarized growth 3.634E-4 7.503E-3 4.831E-2
1.276E-1
 9 187
18 GO:0030133 transport vesicle 4.790E-4 9.341E-3
6.015E-2
1.681E-1
 13 374
19 GO:0097418 neurofibrillary tangle 1.328E-3 2.453E-2
1.580E-1
4.661E-1
 2 5
20 GO:0043195 terminal bouton 2.035E-3 3.474E-2
2.237E-1
7.141E-1
 6 112
21 GO:0042734 presynaptic membrane 2.079E-3 3.474E-2
2.237E-1
7.296E-1
 5 77
Show 16 more annotations

4: Human Phenotype [Display Chart] 689 annotations before applied cutoff / 4410 genes in category

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5: Mouse Phenotype [Display Chart] 3167 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0009937 abnormal neuron differentiation 4.651E-7 1.473E-3 1.272E-2 1.473E-3 22 359
2 MP:0002184 abnormal innervation 1.541E-6 2.439E-3 2.107E-2 4.879E-3 17 241
3 MP:0008503 abnormal spinal cord grey matter morphology 4.031E-6 4.255E-3 3.675E-2 1.277E-2 16 231
4 MP:0002557 abnormal social/conspecific interaction 1.719E-5 8.664E-3
7.484E-2
5.445E-2
 19 350
5 MP:0008415 abnormal neurite morphology 1.954E-5 8.664E-3
7.484E-2
6.188E-2
 21 418
6 MP:0001086 absent petrosal ganglion 2.287E-5 8.664E-3
7.484E-2
7.242E-2
 3 4
7 MP:0002761 abnormal hippocampal mossy fiber morphology 2.350E-5 8.664E-3
7.484E-2
7.443E-2
 6 33
8 MP:0000965 abnormal sensory neuron morphology 2.584E-5 8.664E-3
7.484E-2
8.184E-2
 23 494
9 MP:0002961 abnormal axon guidance 2.824E-5 8.664E-3
7.484E-2
8.945E-2
 8 68
10 MP:0000937 abnormal motor neuron morphology 2.884E-5 8.664E-3
7.484E-2
9.134E-2
 13 185
11 MP:0000955 abnormal spinal cord morphology 3.198E-5 8.664E-3
7.484E-2
1.013E-1
 18 334
12 MP:0009964 abnormal cerebellum lobule morphology 3.283E-5 8.664E-3
7.484E-2
1.040E-1
 10 112
13 MP:0004792 abnormal synaptic vesicle number 3.741E-5 9.114E-3
7.872E-2
1.185E-1
 7 52
14 MP:0000872 abnormal cerebellum external granule cell layer morphology 8.423E-5 1.676E-2
1.447E-1
2.668E-1
 8 79
15 MP:0004769 abnormal synaptic vesicle morphology 8.580E-5 1.676E-2
1.447E-1
2.717E-1
 7 59
16 MP:0006108 abnormal hindbrain development 8.792E-5 1.676E-2
1.447E-1
2.784E-1
 13 206
17 MP:0000857 abnormal cerebellar foliation 8.994E-5 1.676E-2
1.447E-1
2.848E-1
 9 102
18 MP:0000854 abnormal cerebellum development 9.822E-5 1.728E-2
1.493E-1
3.111E-1
 11 153
19 MP:0001402 hypoactivity 2.037E-4 3.396E-2
2.933E-1
6.452E-1
 21 492
20 MP:0000968 abnormal sensory neuron innervation pattern 2.413E-4 3.821E-2
3.301E-1
7.643E-1
 9 116
Show 15 more annotations

6: Domain [Display Chart] 1436 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF04732 Filament head Pfam 6.532E-7 3.929E-4 3.083E-3 9.379E-4 4 7
2 IPR006821 Intermed filament DNA-bd InterPro 6.532E-7 3.929E-4 3.083E-3 9.379E-4 4 7
3 PS00422 GRANINS 1 PROSITE 1.642E-6 3.929E-4 3.083E-3 2.357E-3 3 3
4 IPR001990 Granin InterPro 1.642E-6 3.929E-4 3.083E-3 2.357E-3 3 3
5 IPR018054 Chromogranin CS InterPro 1.642E-6 3.929E-4 3.083E-3 2.357E-3 3 3
6 PF01271 Granin Pfam 1.642E-6 3.929E-4 3.083E-3 2.357E-3 3 3
7 IPR001819 Chromogranin AB InterPro 1.398E-4 1.825E-2
1.432E-1
2.007E-1
 2 2
8 PS00423 GRANINS 2 PROSITE 1.398E-4 1.825E-2
1.432E-1
2.007E-1
 2 2
9 IPR028586 AK3/Ak4 mitochondrial InterPro 1.398E-4 1.825E-2
1.432E-1
2.007E-1
 2 2
10 IPR010508 DUF1088 InterPro 1.398E-4 1.825E-2
1.432E-1
2.007E-1
 2 2
11 PF06469 DUF1088 Pfam 1.398E-4 1.825E-2
1.432E-1
2.007E-1
 2 2
12 PF05191 ADK lid Pfam 4.161E-4 3.859E-2
3.029E-1
5.975E-1
 2 3
13 IPR009431 Calcyon neuron-sp InterPro 4.161E-4 3.859E-2
3.029E-1
5.975E-1
 2 3
14 IPR006259 Adenyl kin sub InterPro 4.161E-4 3.859E-2
3.029E-1
5.975E-1
 2 3
15 PF06387 Calcyon Pfam 4.161E-4 3.859E-2
3.029E-1
5.975E-1
 2 3
16 IPR013606 I-BAR dom InterPro 4.300E-4 3.859E-2
3.029E-1
6.175E-1
 3 13
Show 11 more annotations

7: Pathway [Display Chart] 1103 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 P00001 Adrenaline and noradrenaline biosynthesis PantherDB 1.815E-5 1.526E-2
1.157E-1
 2.002E-2 5 28
2 106516 Transmission across Chemical Synapses BioSystems: REACTOME 2.767E-5 1.526E-2
1.157E-1
 3.052E-2 11 200
3 105688 Axon guidance BioSystems: REACTOME 7.151E-5 2.629E-2
1.994E-1
7.887E-2
 12 262
4 P00002 Alpha adrenergic receptor signaling pathway PantherDB 1.012E-4 2.791E-2
2.116E-1
1.116E-1
 4 21
5 106520 Serotonin Neurotransmitter Release Cycle BioSystems: REACTOME 3.433E-4 4.343E-2
3.293E-1
3.787E-1
 3 12
6 106523 Dopamine Neurotransmitter Release Cycle BioSystems: REACTOME 3.433E-4 4.343E-2
3.293E-1
3.787E-1
 3 12
7 106519 Norepinephrine Neurotransmitter Release Cycle BioSystems: REACTOME 3.433E-4 4.343E-2
3.293E-1
3.787E-1
 3 12
8 P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway PantherDB 3.682E-4 4.343E-2
3.293E-1
4.062E-1
 7 111
9 P05912 Dopamine receptor mediated signaling pathway PantherDB 3.813E-4 4.343E-2
3.293E-1
4.206E-1
 5 52
10 217716 Cholinergic synapse BioSystems: KEGG 4.105E-4 4.343E-2
3.293E-1
4.528E-1
 7 113
11 525336 Serotonergic synapse BioSystems: KEGG 4.331E-4 4.343E-2
3.293E-1
4.777E-1
 7 114
12 P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway PantherDB 4.959E-4 4.558E-2
3.457E-1
5.470E-1
 5 55
Show 7 more annotations

8: Pubmed [Display Chart] 23770 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20201926:gr Human variation in alcohol response is influenced by variation in neuronal signaling genes. GeneRIF 1.954E-11 2.322E-7 2.474E-6 4.644E-7 12 171
2 20201926 Human variation in alcohol response is influenced by variation in neuronal signaling genes. Pubmed 1.954E-11 2.322E-7 2.474E-6 4.644E-7 12 171
3 20213320 How the projection domains of NF-L and alpha-internexin determine the conformations of NF-M and NF-H in neurofilaments. Pubmed 3.706E-10 1.258E-6 1.341E-5 8.808E-6 4 4
4 20213320:gr How the projection domains of NF-L and alpha-internexin determine the conformations of NF-M and NF-H in neurofilaments. GeneRIF 3.706E-10 1.258E-6 1.341E-5 8.808E-6 4 4
5 17005864:gr Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS. GeneRIF 3.706E-10 1.258E-6 1.341E-5 8.808E-6 4 4
6 21046454:gr Immunohistochemical and biochemical studies with region-specific antibodies to chromogranins A and B and secretogranins II and III in neuroendocrine tumors. GeneRIF 3.706E-10 1.258E-6 1.341E-5 8.808E-6 4 4
7 21046454 Immunohistochemical and biochemical studies with region-specific antibodies to chromogranins A and B and secretogranins II and III in neuroendocrine tumors. Pubmed 3.706E-10 1.258E-6 1.341E-5 8.808E-6 4 4
8 16084104 Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis. Pubmed 8.502E-8 1.347E-4 1.435E-3 2.021E-3 3 3
9 20550951:gr Secretogranin III in human neuroendocrine tumours: a comparative immunohistochemical study with chromogranins A and B and secretogranin II. GeneRIF 8.502E-8 1.347E-4 1.435E-3 2.021E-3 3 3
10 22857951:gr Molecular basis for specific regulation of neuronal kinesin-3 motors by doublecortin family proteins. GeneRIF 8.502E-8 1.347E-4 1.435E-3 2.021E-3 3 3
11 18721831:gr Chromogranin peptides in amyotrophic lateral sclerosis. GeneRIF 8.502E-8 1.347E-4 1.435E-3 2.021E-3 3 3
12 18721831 Chromogranin peptides in amyotrophic lateral sclerosis. Pubmed 8.502E-8 1.347E-4 1.435E-3 2.021E-3 3 3
13 23423580 Increased fecal levels of chromogranin A, chromogranin B, and secretoneurin in collagenous colitis. Pubmed 8.502E-8 1.347E-4 1.435E-3 2.021E-3 3 3
14 20550951 Secretogranin III in human neuroendocrine tumours: a comparative immunohistochemical study with chromogranins A and B and secretogranin II. Pubmed 8.502E-8 1.347E-4 1.435E-3 2.021E-3 3 3
15 16084104:gr Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis. GeneRIF 8.502E-8 1.347E-4 1.435E-3 2.021E-3 3 3
16 19086053 Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. Pubmed 1.183E-7 1.654E-4 1.762E-3 2.811E-3 11 300
17 19086053:gr Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. GeneRIF 1.183E-7 1.654E-4 1.762E-3 2.811E-3 11 300
18 21044950 Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Pubmed 3.058E-7 4.038E-4 4.302E-3 7.269E-3 11 330
19 19457133:gr RE1 silencing transcription factor is involved in regulating neuron-specific expression of alpha-internexin and neurofilament genes. GeneRIF 3.390E-7 4.240E-4 4.518E-3 8.057E-3 3 4
20 17043677 Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Pubmed 4.132E-7 4.911E-4 5.232E-3 9.823E-3 8 151
21 20808911:gr A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice. GeneRIF 8.430E-7 8.365E-4 8.912E-3 2.004E-2 4 17
22 9039501 Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles. Pubmed 8.446E-7 8.365E-4 8.912E-3 2.008E-2 3 5
23 14662745 NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth. Pubmed 8.446E-7 8.365E-4 8.912E-3 2.008E-2 3 5
24 23361940 Altered PTEN, ATRX, CHGA, CHGB, and TP53 expression are associated with aggressive VHL-associated pancreatic neuroendocrine tumors. Pubmed 8.446E-7 8.365E-4 8.912E-3 2.008E-2 3 5
25 23041239 Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Pubmed 1.684E-6 1.601E-3 1.705E-2 4.002E-2 3 6
26 19058789:gr A common variant in DRD3 receptor is associated with autism spectrum disorder. GeneRIF 1.892E-6 1.665E-3 1.774E-2 4.496E-2 7 129
27 19058789 A common variant in DRD3 receptor is associated with autism spectrum disorder. Pubmed 1.892E-6 1.665E-3 1.774E-2 4.496E-2 7 129
28 24722188 Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Pubmed 1.997E-6 1.696E-3 1.806E-2 4.748E-2 11 400
29 26460568 Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. Pubmed 2.070E-6 1.697E-3 1.808E-2 4.921E-2 8 187
30 25108383 Genome-wide association analyses identify variants in developmental genes associated with hypospadias. Pubmed 4.358E-6 3.251E-3 3.463E-2
1.036E-1
 4 25
31 24024966 Genome-wide association study of chronic periodontitis in a general German population. Pubmed 4.910E-6 3.251E-3 3.463E-2
1.167E-1
 6 97
32 9872452 Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Pubmed 6.205E-6 3.251E-3 3.463E-2
1.475E-1
 6 101
33 14997482 Identification and characterization of phosphorylated proteins in the human pituitary. Pubmed 9.971E-6 3.251E-3 3.463E-2
2.370E-1
 3 10
34 23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Pubmed 1.070E-5 3.251E-3 3.463E-2
2.544E-1
 5 65
35 18660489 Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. Pubmed 1.732E-5 3.251E-3 3.463E-2
4.117E-1
 8 250
36 18660489:gr Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. GeneRIF 1.732E-5 3.251E-3 3.463E-2
4.117E-1
 8 250
37 24509480 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Pubmed 1.768E-5 3.251E-3 3.463E-2
4.203E-1
 5 72
38 20062060 Genome-wide association study of PR interval. Pubmed 1.816E-5 3.251E-3 3.463E-2
4.317E-1
 3 12
39 20634891:gr Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. GeneRIF 1.882E-5 3.251E-3 3.463E-2
4.475E-1
 9 331
40 20634891 Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Pubmed 1.882E-5 3.251E-3 3.463E-2
4.475E-1
 9 331
41 23715162 A study of gata3 and phox2b expression in tumors of the autonomic nervous system. Pubmed 1.942E-5 3.251E-3 3.463E-2
4.616E-1
 2 2
42 23082988 Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma. Pubmed 1.942E-5 3.251E-3 3.463E-2
4.616E-1
 2 2
43 19716167:gr Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. GeneRIF 1.942E-5 3.251E-3 3.463E-2
4.616E-1
 2 2
44 14755443 Confirming RGS4 as a susceptibility gene for schizophrenia. Pubmed 1.942E-5 3.251E-3 3.463E-2
4.616E-1
 2 2
45 18216174:gr Evidence for an evolutionary conserved role of homothorax/Meis1/2 during vertebrate retina development. GeneRIF 1.942E-5 3.251E-3 3.463E-2
4.616E-1
 2 2
46 9388258 Heterodimeric associations between neuronal intermediate filament proteins. Pubmed 1.942E-5 3.251E-3 3.463E-2
4.616E-1
 2 2
47 20855530:gr Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3. GeneRIF 1.942E-5 3.251E-3 3.463E-2
4.616E-1
 2 2
48 12165659 Chromogranin A and chromogranin B in noninvasive and invasive breast carcinoma. Pubmed 1.942E-5 3.251E-3 3.463E-2
4.616E-1
 2 2
49 10544043 Cloning and functional characterization of the promoter region of the gene encoding human adenylate kinase isozyme 3. Pubmed 1.942E-5 3.251E-3 3.463E-2
4.616E-1
 2 2
50 26621503 HDAC9, TWIST1 and FERD3L gene expression in asymptomatic stable and unstable carotid plaques. Pubmed 1.942E-5 3.251E-3 3.463E-2
4.616E-1
 2 2
Show 45 more annotations

9: Interaction [Display Chart] 3661 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:DGUOK DGUOK interactions 1.822E-7 6.669E-4 5.858E-3 6.669E-4 9 66
2 int:DNAAF2 DNAAF2 interactions 3.144E-6 5.755E-3
5.054E-2
 1.151E-2 8 69
3 int:NUFIP1 NUFIP1 interactions 3.418E-5 3.161E-2
2.776E-1
1.251E-1
 8 95
4 int:MAB21L2 MAB21L2 interactions 3.454E-5 3.161E-2
2.776E-1
1.264E-1
 4 15
5 int:PBX3 PBX3 interactions 6.400E-5 4.686E-2
4.116E-1
2.343E-1
 5 33

10: Cytoband [Display Chart] 193 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17q22 17q22 5.278E-7 1.019E-4 5.951E-4 1.019E-4 6 46
2 13q13 13q13 2.673E-6 2.580E-4 1.507E-3 5.160E-4 3 5
3 8p21 8p21 2.836E-4 1.824E-2
1.066E-1
5.473E-2
 3 20

11: Transcription Factor Binding Site [Display Chart] 544 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 YAATNRNNNYNATT UNKNOWN YAATNRNNNYNATT UNKNOWN 1.426E-6 3.957E-4 2.722E-3 7.759E-4 10 86
2 V$CDX2 Q5 V$CDX2 Q5 1.455E-6 3.957E-4 2.722E-3 7.915E-4 15 205
3 V$COMP1 01 V$COMP1 01 4.332E-6 7.856E-4 5.403E-3 2.357E-3 10 97
4 V$CHOP 01 V$CHOP 01 1.740E-5 2.367E-3 1.628E-2 9.467E-3 13 192
5 YCATTAA UNKNOWN YCATTAA UNKNOWN 2.410E-5 2.622E-3 1.803E-2 1.311E-2 21 462
6 V$S8 01 V$S8 01 4.049E-5 2.752E-3 1.893E-2 2.203E-2 13 208
7 V$NRSF 01 V$NRSF 01 4.209E-5 2.752E-3 1.893E-2 2.290E-2 8 78
8 V$IPF1 Q4 V$IPF1 Q4 4.256E-5 2.752E-3 1.893E-2 2.315E-2 13 209
9 V$CART1 01 V$CART1 01 4.553E-5 2.752E-3 1.893E-2 2.477E-2 12 181
10 WGTTNNNNNAAA UNKNOWN WGTTNNNNNAAA UNKNOWN 5.251E-5 2.857E-3 1.965E-2 2.857E-2 20 450
11 V$PAX4 04 V$PAX4 04 1.313E-4 6.491E-3 4.464E-2
7.141E-2
 11 172
12 V$NKX25 02 V$NKX25 02 1.577E-4 6.707E-3 4.613E-2
8.577E-2
 12 206
13 CAGNWMCNNNGAC UNKNOWN CAGNWMCNNNGAC UNKNOWN 1.652E-4 6.707E-3 4.613E-2
8.987E-2
 7 71
14 V$STAT6 01 V$STAT6 01 1.726E-4 6.707E-3 4.613E-2
9.390E-2
 12 208
15 V$OCT1 05 V$OCT1 05 2.154E-4 7.812E-3
5.373E-2
1.172E-1
 12 213
16 V$HAND1E47 01 V$HAND1E47 01 2.903E-4 9.872E-3
6.789E-2
1.579E-1
 12 220
17 V$SOX9 B1 V$SOX9 B1 3.429E-4 1.065E-2
7.324E-2
1.866E-1
 11 192
18 V$EVI1 04 V$EVI1 04 3.747E-4 1.065E-2
7.324E-2
2.039E-1
 11 194
19 V$OCT1 06 V$OCT1 06 3.864E-4 1.065E-2
7.324E-2
2.102E-1
 12 227
20 V$CHX10 01 V$CHX10 01 3.915E-4 1.065E-2
7.324E-2
2.130E-1
 11 195
21 AAANWWTGC UNKNOWN AAANWWTGC UNKNOWN 4.728E-4 1.148E-2
7.894E-2
2.572E-1
 10 168
22 V$FREAC3 01 V$FREAC3 01 4.853E-4 1.148E-2
7.894E-2
2.640E-1
 11 200
23 V$OCT1 04 V$OCT1 04 4.853E-4 1.148E-2
7.894E-2
2.640E-1
 11 200
24 V$IRF1 01 V$IRF1 01 5.502E-4 1.247E-2
8.576E-2
2.993E-1
 11 203
25 V$FXR Q3 V$FXR Q3 6.673E-4 1.411E-2
9.702E-2
3.630E-1
 7 89
26 V$AREB6 04 V$AREB6 04 6.743E-4 1.411E-2
9.702E-2
3.668E-1
 11 208
27 V$SOX5 01 V$SOX5 01 7.896E-4 1.573E-2
1.082E-1
4.296E-1
 11 212
28 V$CDP 02 V$CDP 02 8.140E-4 1.573E-2
1.082E-1
4.428E-1
 7 92
29 GCCNNNWTAAR UNKNOWN GCCNNNWTAAR UNKNOWN 8.385E-4 1.573E-2
1.082E-1
4.561E-1
 8 120
30 V$FOXJ2 01 V$FOXJ2 01 9.869E-4 1.688E-2
1.161E-1
5.369E-1
 9 153
31 V$OCT C V$OCT C 9.931E-4 1.688E-2
1.161E-1
5.403E-1
 11 218
32 V$TST1 01 V$TST1 01 9.931E-4 1.688E-2
1.161E-1
5.403E-1
 11 218
33 V$NKX61 01 V$NKX61 01 1.042E-3 1.718E-2
1.182E-1
5.670E-1
 10 186
34 V$AREB6 03 V$AREB6 03 1.326E-3 2.044E-2
1.405E-1
7.212E-1
 10 192
35 V$OCT1 07 V$OCT1 07 1.342E-3 2.044E-2
1.405E-1
7.299E-1
 8 129
36 V$HNF3 Q6 V$HNF3 Q6 1.352E-3 2.044E-2
1.405E-1
7.357E-1
 9 160
37 SMTTTTGT UNKNOWN SMTTTTGT UNKNOWN 1.412E-3 2.075E-2
1.427E-1
7.679E-1
 14 337
38 V$PIT1 Q6 V$PIT1 Q6 1.548E-3 2.171E-2
1.493E-1
8.419E-1
 10 196
39 V$MEF2 02 V$MEF2 02 1.607E-3 2.171E-2
1.493E-1
8.745E-1
 10 197
40 V$MEF2 03 V$MEF2 03 1.669E-3 2.171E-2
1.493E-1
9.081E-1
 10 198
41 V$GATA1 02 V$GATA1 02 1.733E-3 2.171E-2
1.493E-1
9.427E-1
 10 199
42 V$SRY 02 V$SRY 02 1.733E-3 2.171E-2
1.493E-1
9.427E-1
 10 199
43 V$NKX62 Q2 V$NKX62 Q2 1.733E-3 2.171E-2
1.493E-1
9.427E-1
 10 199
44 GTGGGTGK UNKNOWN GTGGGTGK UNKNOWN 1.756E-3 2.171E-2
1.493E-1
9.554E-1
 11 234
45 V$SPZ1 01 V$SPZ1 01 1.936E-3 2.336E-2
1.606E-1
1.000E0
 10 202
46 V$FAC1 01 V$FAC1 01 1.975E-3 2.336E-2
1.606E-1
1.000E0
 9 169
47 V$CEBP Q3 V$CEBP Q3 2.082E-3 2.410E-2
1.657E-1
1.000E0
 10 204
48 V$ALPHACP1 01 V$ALPHACP1 01 2.158E-3 2.432E-2
1.673E-1
1.000E0
 10 205
49 V$CDPCR1 01 V$CDPCR1 01 2.191E-3 2.432E-2
1.673E-1
1.000E0
 7 109
50 V$RSRFC4 01 V$RSRFC4 01 2.400E-3 2.458E-2
1.690E-1
1.000E0
 10 208
Show 45 more annotations

12: Gene Family [Display Chart] 127 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 611 Intermediate filaments Type IV|Protein phosphatase 1 regulatory subunits genenames.org 7.119E-8 9.041E-6 4.905E-5 9.041E-6 4 6
2 925 Granins genenames.org 3.279E-7 2.082E-5 1.130E-4 4.164E-5 4 8
3 1140 Tropomodulins genenames.org 4.169E-4 1.324E-2
7.181E-2
5.295E-2
 2 4
4 1044 EYA transcriptional coactivator and phosphatases genenames.org 4.169E-4 1.324E-2
7.181E-2
5.295E-2
 2 4

13: Coexpression [Display Chart] 6619 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M15762 Neuroblastoma markers down-regulated in neuroblastoma cell lines expressing ESWR1-FLI1 [GeneID=2130;2313] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.252E-33 1.491E-29 1.398E-28 1.491E-29 20 30
2 M16108 Genes down-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402], a protease inhibitor causing apoptosis. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.608E-23 2.187E-19 2.050E-18 4.374E-19 26 172
3 M2892 Genes up-regulated in epithelial kidney cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v5.1) 3.523E-17 7.773E-14 7.287E-13 2.332E-13 20 143
4 M2506 Genes up-regulated in the neural crest stem cells (NCS), defined as p75+/HNK1+ [GeneID=4804;27087]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.356E-14 2.244E-11 2.103E-10 8.975E-11 18 146
5 M2395 Genes up-regulated in pancreatic islets upon knockout of HNF1A [GeneID=6927]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.211E-12 1.603E-9 1.503E-8 8.014E-9 17 163
6 M2446 Genes down-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 10 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.028E-11 9.960E-8 9.337E-7 5.976E-7 18 244
7 M12135 Genes down-regulated in apoptotic tissues (neuroepithelium) after MDM4 [GeneID=4194] knockout. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.744E-10 1.649E-7 1.546E-6 1.154E-6 15 164
8 M2115 Genes correlated with proneural type of glioblastoma multiforme tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.114E-10 4.231E-7 3.966E-6 3.385E-6 15 177
9 M18532 Genes positively correlated with amplifications of MYCN [GeneID=4613] in the SCLC (small cell lung cancer) cell lines. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.906E-9 2.137E-6 2.004E-5 1.923E-5 11 92
10 M2882 Genes up-regulated in four lineages of epithelial cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v5.1) 5.962E-9 3.946E-6 3.699E-5 3.946E-5 17 280
11 M1349 Genes down-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 12 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.710E-9 4.038E-6 3.785E-5 4.441E-5 9 57
12 M4008 Genes which best discriminate between two groups of breast cancer according to the status of ESR1 and AR [GeneID=2099;367]: apocrine (ESR1- AR+) and luminal (ESR1+ AR+). MSigDB C2: CGP Curated Gene Sets (v5.1) 9.292E-9 5.125E-6 4.805E-5 6.151E-5 18 326
13 GSE10240 CTRL VS IL17 AND IL22 STIM PRIMARY BRONCHIAL EPITHELIAL CELLS DN Genes down-regulated in primary bronchial epithelial cells: control versus stimulated with IL17A and IL22 [GeneID=3605;50616]. MSigDB C7: Immunologic Signatures (v5.1) 2.296E-8 1.169E-5 1.096E-4 1.520E-4 14 200
14 M7363 Genes up-regulated in MCF7 cells (breast cancer) under hypoxia conditions. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.774E-8 1.311E-5 1.229E-4 1.836E-4 13 171
15 M2293 Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.396E-8 1.498E-5 1.405E-4 2.248E-4 17 315
16 M1712 Genes enriched in neurons in the adult mouse brain identified through correlation-based searches seeded with neuron cell-type specific gene expression patterns. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.797E-8 1.571E-5 1.472E-4 2.513E-4 9 69
17 M15472 Down-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.468E-8 2.129E-5 1.996E-4 3.619E-4 18 366
18 M768 Genes commonly up-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.217E-8 2.587E-5 2.425E-4 4.777E-4 10 98
19 M5919 Genes up-regulated by activation of hedgehog signaling. MSigDB H: Hallmark Gene Sets (v5.1) 7.426E-8 2.587E-5 2.425E-4 4.915E-4 7 36
20 M2580 Genes consistently down-regulated in mature mammary luminal cells both in mouse and human species. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.956E-8 2.633E-5 2.468E-4 5.266E-4 10 99
21 M9197 Genes up-regulated in MCF7 cells (breast cancer) treated with hypoxia mimetic DMOG [PubChem=3080614]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.115E-7 3.513E-5 3.294E-4 7.377E-4 11 130
22 GSE40068 CXCR5POS BCL6POS TFH VS CXCR5NEG BCL6NEG CD4 TCELL DN Genes down-regulated in CXCR5+ BCL6+ [GeneID=643;604] follicular helper T cells versus CXCR5- BCL6- CD4+ [GeneID=643;604;920] T cells. MSigDB C7: Immunologic Signatures (v5.1) 1.751E-7 5.268E-5 4.939E-4 1.159E-3 13 200
23 M2351 Genes down-regulated in leukemic progenitor cells expressing activated fusion of ESWR1 and FLI1 [GeneID=2130, 2313] compared to normal hematopoetic progenitors. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.564E-7 7.185E-5 6.736E-4 1.697E-3 16 321
24 M2081 Genes down-regulated by TGFB1 [GeneID=7040] in MEF cells (embryonic fibroblast) via TGFB1R [GeneID=7046]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.605E-7 7.185E-5 6.736E-4 1.724E-3 13 207
25 M2875 Genes up-regulated in four lineages of epithelial cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v5.1) 2.945E-7 7.797E-5 7.310E-4 1.949E-3 11 143
26 M13206 Genes down-regulated in TC71 and EWS502 cells (Ewing's sarcoma) by EWSR1-FLI1 [GeneID=2130;2314] as inferred from RNAi knockdown of this fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.155E-7 8.033E-5 7.531E-4 2.089E-3 16 326
27 M14791 Genes down-regulated in colorectal adenoma compared to normal mucosa samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.006E-7 9.820E-5 9.206E-4 2.651E-3 15 291
28 M2256 Genes commonly down-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313 ,2078]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.461E-7 1.764E-4 1.653E-3 4.938E-3 13 227
29 M14228 Cluster a: genes identifying an intrinsic group in head and neck squamous cell carcinoma (HNSCC). MSigDB C2: CGP Curated Gene Sets (v5.1) 9.659E-7 2.131E-4 1.998E-3 6.394E-3 9 100
30 M2808 Genes up-regulated in neurons. MSigDB C6: Oncogenic Signatures (v5.1) 9.659E-7 2.131E-4 1.998E-3 6.394E-3 9 100
31 M1804 Genes up-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.412E-6 3.014E-4 2.826E-3 9.344E-3 14 280
32 M4661 Genes up-regulated in granulocytes by RUNX1-RUNX1T1 [GeneID=861;862] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.528E-6 3.116E-4 2.921E-3 1.011E-2 7 55
33 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.553E-6 3.116E-4 2.921E-3 1.028E-2 18 460
34 M6316 Genes up-regulated in macrophages: control versus Sendai virus infection. MSigDB C7: Immunologic Signatures (v5.1) 1.649E-6 3.211E-4 3.010E-3 1.092E-2 11 170
35 M14601 Genes up-regulated in hepatoblastoma samples compared to normal liver tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.764E-6 3.337E-4 3.128E-3 1.168E-2 12 207
36 M2142 Genes up-regulated in SH-SY5Y cells (neuroblastoma) after knockdown of NF1 [GeneID=4763] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.899E-6 3.491E-4 3.273E-3 1.257E-2 10 139
37 M2012 Genes up-regulated in mARMS (molecular ARMS) compared to the mERMS (molecular ERMS) class of rhabdomyosarcoma tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.010E-6 3.596E-4 3.371E-3 1.331E-2 15 331
38 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.277E-6 3.955E-4 3.708E-3 1.507E-2 17 425
39 M16478 Genes down-regulated in medulloblastoma tumors from animals with inactivating mutations of one copy of PTCH1 or SUFU [GeneID=5727;51684] in conjunction with TP53 [GeneID=7157] loss. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.330E-6 3.955E-4 3.708E-3 1.543E-2 8 83
40 M5942 Genes down-regulated in response to ultraviolet (UV) radiation. MSigDB H: Hallmark Gene Sets (v5.1) 2.616E-6 4.226E-4 3.962E-3 1.731E-2 10 144
41 M14877 Genes down-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [GeneID=4904] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.618E-6 4.226E-4 3.962E-3 1.733E-2 16 383
42 M1760 Genes down-regulated after Cre-lox knockout of LSD1 [GeneID=23028] in pituitary. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.798E-6 4.410E-4 4.134E-3 1.852E-2 6 39
43 M2681 Genes down-regulated in myometrial cells over-expressing a shortened splice form of ATF2 [Gene ID=1386] gene. MSigDB C6: Oncogenic Signatures (v5.1) 4.163E-6 6.408E-4 6.008E-3 2.755E-2 11 187
44 M2571 Genes down-regulated during prostate cancer progression in the JOCK1 model due to inducible activation of FGFR1 [GeneID=2260] gene in prostate. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.286E-6 6.447E-4 6.044E-3 2.837E-2 14 308
45 M15031 Genes up-regulated in MCF10A cells (breast cancer) by expression of LSM1 [GeneID=27257] off a letiviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.798E-6 8.529E-4 7.996E-3 3.838E-2 6 44
46 M1369 Predicted targets of SOX9 [GeneID=6662] that are down-regulated during early prostate development. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.633E-6 9.544E-4 8.948E-3 4.390E-2 6 45
47 GSE46606 UNSTIM VS CD40L IL2 IL5 DAY3 STIMULATED BCELL UP Genes up-regulated in at day 0 B cell wildtype versus CD40L and IL-2 IL-4 IL-5 stimulated at day 3 B cell wildtype. MSigDB C7: Immunologic Signatures (v5.1) 7.191E-6 9.815E-4 9.202E-3 4.760E-2 11 198
48 M5215 Genes up-regulated in comparison of dendritic cells (DC) exposed to T. gondii versus DCs exposed to 50 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v5.1) 7.544E-6 9.815E-4 9.202E-3 4.993E-2 11 199
49 M6895 Genes up-regulated in macrophages with IL10 [GeneID=3586] knockout in response to 10 min treatment by: LPS versus LPS and IL10 [GeneID=3586]. MSigDB C7: Immunologic Signatures (v5.1) 7.544E-6 9.815E-4 9.202E-3 4.993E-2 11 199
50 GSE41176 UNSTIM VS ANTI IGM STIM BCELL 24H UP Genes up-regulated in B lymphocytes: untreated versus anti-IgM for 24h. MSigDB C7: Immunologic Signatures (v5.1) 7.544E-6 9.815E-4 9.202E-3 4.993E-2 11 199
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 3529 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 500 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.868E-55 1.718E-51 1.503E-50 1.718E-51 64 423
2 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k1 1000 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.407E-54 2.483E-51 2.171E-50 4.965E-51 51 211
3 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 500 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 7.548E-54 8.879E-51 7.766E-50 2.664E-50 64 441
4 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k4 1000 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.372E-52 2.975E-49 2.602E-48 1.190E-48 54 279
5 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k1 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.981E-48 2.104E-45 1.840E-44 1.052E-44 40 125
6 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 200 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 1.158E-45 6.812E-43 5.958E-42 4.087E-42 44 194
7 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.636E-41 1.329E-38 1.162E-37 9.303E-38 51 372
8 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 k4 1000 dev lower uro neuro e14.5 PelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.055E-40 4.397E-38 3.846E-37 3.724E-37 36 131
9 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 200 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 1.121E-40 4.397E-38 3.846E-37 3.957E-37 39 170
10 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k2 500 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.312E-39 8.158E-37 7.135E-36 8.158E-36 35 129
11 54Dp Top 500 Cluster 0 54Dp Top 500 Cluster 0 Brain Map - Allen iN 6.383E-39 1.877E-36 1.642E-35 2.252E-35 54 485
12 54Dp Top 500 All 54Dp Top 500 All Brain Map - Allen iN 6.383E-39 1.877E-36 1.642E-35 2.252E-35 54 485
13 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k3 1000 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 7.256E-39 1.970E-36 1.723E-35 2.561E-35 40 203
14 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k1 1000 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.227E-37 3.092E-35 2.705E-34 4.329E-34 40 217
15 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 k1 500 dev lower uro neuro e14.5 PelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.174E-36 7.467E-34 6.531E-33 1.120E-32 29 84
16 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 100 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 4.182E-34 9.223E-32 8.067E-31 1.476E-30 29 97
17 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k2 1000 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.243E-32 2.580E-30 2.256E-29 4.386E-29 36 211
18 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k2 500 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.610E-30 5.117E-28 4.476E-27 9.211E-27 29 127
19 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 500 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.596E-30 6.678E-28 5.841E-27 1.269E-26 44 427
20 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 1000 k3 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.780E-29 3.141E-27 2.747E-26 6.282E-26 29 135
21 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 100 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 3.421E-29 5.748E-27 5.027E-26 1.207E-25 24 75
22 80Dp Top 500 All 80Dp Top 500 All Brain Map - Allen iN 1.168E-28 1.874E-26 1.639E-25 4.122E-25 45 491
23 26Dp Top 500 All 26Dp Top 500 All Brain Map - Allen iN 1.653E-28 2.537E-26 2.219E-25 5.834E-25 45 495
24 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 200 dev lower uro neuro e15.5 PelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 3.083E-28 4.534E-26 3.965E-25 1.088E-24 29 148
25 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k4 200 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 8.581E-28 1.211E-25 1.059E-24 3.028E-24 21 54
26 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k2 500 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.939E-27 6.704E-25 5.864E-24 1.743E-23 26 116
27 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 500 dev lower uro neuro e14.5 PelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.434E-26 1.875E-24 1.640E-23 5.061E-23 42 463
28 neurons Top 500 All neurons Top 500 All Brain Map - Barres 1.801E-26 2.270E-24 1.985E-23 6.355E-23 43 494
29 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k4 200 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 2.815E-26 3.425E-24 2.996E-23 9.933E-23 21 62
30 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 500 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.823E-26 6.850E-24 5.991E-23 2.055E-22 40 424
31 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 500 k2 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.919E-25 5.600E-23 4.898E-22 1.736E-21 24 107
32 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 1000 k1 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.021E-24 2.229E-22 1.950E-21 7.134E-21 24 113
33 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k1 200 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 4.535E-24 4.850E-22 4.242E-21 1.601E-20 19 55
34 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 k4 200 dev lower uro neuro e14.5 PelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 2.994E-22 3.107E-20 2.718E-19 1.056E-18 17 46
35 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k5 200 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k-means-cluster#5 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.081E-21 1.089E-19 9.529E-19 3.813E-18 17 49
36 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 200 dev lower uro neuro e14.5 PelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 5.480E-21 5.372E-19 4.698E-18 1.934E-17 26 194
37 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 200 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 9.948E-21 9.488E-19 8.299E-18 3.511E-17 25 178
38 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 100 k2 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 9.721E-20 9.028E-18 7.896E-17 3.430E-16 13 25
39 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 100 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 2.082E-19 1.884E-17 1.648E-16 7.346E-16 19 91
40 gudmap developingLowerUrinaryTract e14.5 urogenital sinus 1000 k3 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-5517 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.268E-19 3.765E-17 3.293E-16 1.506E-15 25 207
41 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k1 100 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 6.801E-19 5.854E-17 5.120E-16 2.400E-15 13 28
42 26Dp SubClass 26Dp 4 Top 500 All 26Dp SubClass 26Dp 4 Top 500 All Brain Map - Allen iN 1.013E-18 8.516E-17 7.448E-16 3.577E-15 35 494
43 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k2 100 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.653E-18 1.356E-16 1.186E-15 5.832E-15 14 38
44 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 100 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 3.499E-18 2.806E-16 2.454E-15 1.235E-14 18 89
45 12Dp Top 500 Cluster 0 12Dp Top 500 Cluster 0 Brain Map - Allen iN 3.891E-18 3.051E-16 2.669E-15 1.373E-14 14 40
46 gudmap developingLowerUrinaryTract P1 bladder J 1000 k4 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.332E-18 3.323E-16 2.907E-15 1.529E-14 18 90
47 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 500 k1 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.852E-18 4.394E-16 3.843E-15 2.065E-14 14 41
48 Facebase RNAseq e10.5 Olfactory Pit 500 FacebaseRNAseq e10.5 Olfactory Pit top-relative-expression-ranked 500 FaceBase_RNAseq 8.622E-18 6.339E-16 5.544E-15 3.043E-14 34 495
49 gudmap developingGonad e11.5 ovary + mesonephros k3 1000 DevelopingGonad e11.5 ovary + mesonephros emap-3226 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 9.241E-18 6.622E-16 5.792E-15 3.261E-14 19 110
50 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 200 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 9.383E-18 6.622E-16 5.792E-15 3.311E-14 22 167
Show 45 more annotations

15: Computational [Display Chart] 455 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 9.559E-11 4.349E-8 2.913E-7 4.349E-8 28 378
2 GNF2 RTN1 Neighborhood of RTN1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 8.918E-8 2.029E-5 1.359E-4 4.058E-5 9 46
3 GNF2 AF1Q Neighborhood of AF1Q MSigDb: C4 - CGN: Cancer Gene Neighborhood 9.069E-7 1.376E-4 9.214E-4 4.127E-4 6 20
4 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 3.832E-6 3.560E-4 2.385E-3 1.744E-3 20 351
5 GNF2 MAPT Neighborhood of MAPT MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.912E-6 3.560E-4 2.385E-3 1.780E-3 7 38
6 module 19 Genes in module 19 MSigDb: C4 - CM: Cancer Modules 3.089E-5 2.020E-3 1.353E-2 1.406E-2 17 307
7 GNF2 DNM1 Neighborhood of DNM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.108E-5 2.020E-3 1.353E-2 1.414E-2 8 70
8 module 176 Genes in module 176 MSigDb: C4 - CM: Cancer Modules 1.972E-4 1.122E-2
7.514E-2
8.974E-2
 13 227
9 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 2.264E-4 1.145E-2
7.667E-2
1.030E-1
 17 361
10 GNF2 RAB3A Neighborhood of RAB3A MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.058E-4 1.391E-2
9.320E-2
1.391E-1
 5 34
11 MORF THPO Neighborhood of THPO MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.518E-4 1.455E-2
9.747E-2
1.601E-1
 9 124
12 module 129 Genes in module 129 MSigDb: C4 - CM: Cancer Modules 4.781E-4 1.813E-2
1.214E-1
2.176E-1
 12 217
13 module 112 Genes in module 112 MSigDb: C4 - CM: Cancer Modules 6.516E-4 2.280E-2
1.528E-1
2.965E-1
 13 257
14 module 220 Genes in module 220 MSigDb: C4 - CM: Cancer Modules 7.249E-4 2.356E-2
1.578E-1
3.298E-1
 15 328
15 module 533 Genes in module 533 MSigDb: C4 - CM: Cancer Modules 8.337E-4 2.529E-2
1.694E-1
3.793E-1
 5 42
16 module 381 Genes in module 381 MSigDb: C4 - CM: Cancer Modules 1.077E-3 3.063E-2
2.052E-1
4.901E-1
 3 12
17 module 438 Genes in module 438 MSigDb: C4 - CM: Cancer Modules 1.172E-3 3.137E-2
2.101E-1
5.332E-1
 6 67
Show 12 more annotations

16: MicroRNA [Display Chart] 1447 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-129-5p:PITA hsa-miR-129-5p:PITA TOP PITA 9.703E-12 8.005E-9 6.288E-8 1.404E-8 27 487
2 hsa-miR-129-5p:TargetScan hsa-miR-129-5p:TargetScan TargetScan 1.106E-11 8.005E-9 6.288E-8 1.601E-8 23 348
3 hsa-miR-1324:PITA hsa-miR-1324:PITA TOP PITA 2.388E-11 1.152E-8 9.048E-8 3.456E-8 22 328
4 hsa-miR-452:PITA hsa-miR-452:PITA TOP PITA 1.850E-9 5.400E-7 4.242E-6 2.677E-6 23 451
5 miR-137:PicTar miR-137:PicTar PicTar 1.866E-9 5.400E-7 4.242E-6 2.700E-6 21 375
6 hsa-miR-498:PITA hsa-miR-498:PITA TOP PITA 5.623E-9 1.356E-6 1.065E-5 8.137E-6 17 256
7 hsa-miR-1252:PITA hsa-miR-1252:PITA TOP PITA 8.801E-9 1.819E-6 1.429E-5 1.273E-5 20 371
8 hsa-miR-768-3p:PITA hsa-miR-768-3p:PITA TOP PITA 2.824E-8 5.109E-6 4.013E-5 4.087E-5 19 359
9 hsa-miR-488:PITA hsa-miR-488:PITA TOP PITA 3.492E-8 5.159E-6 4.052E-5 5.053E-5 18 326
10 hsa-miR-605:PITA hsa-miR-605:PITA TOP PITA 3.565E-8 5.159E-6 4.052E-5 5.159E-5 17 290
11 hsa-miR-616:PITA hsa-miR-616:PITA TOP PITA 4.724E-8 6.214E-6 4.881E-5 6.836E-5 12 136
12 hsa-miR-33a:PITA hsa-miR-33a:PITA TOP PITA 5.789E-8 6.823E-6 5.359E-5 8.377E-5 15 230
13 hsa-miR-33b:PITA hsa-miR-33b:PITA TOP PITA 6.130E-8 6.823E-6 5.359E-5 8.870E-5 15 231
14 hsa-miR-1248:PITA hsa-miR-1248:PITA TOP PITA 8.586E-8 8.875E-6 6.971E-5 1.242E-4 15 237
15 hsa-miR-127-5p:PITA hsa-miR-127-5p:PITA TOP PITA 1.552E-7 1.497E-5 1.176E-4 2.245E-4 15 248
16 miR-206:PicTar miR-206:PicTar PicTar 1.799E-7 1.627E-5 1.278E-4 2.603E-4 19 404
17 miR-1:PicTar miR-1:PicTar PicTar 2.094E-7 1.741E-5 1.367E-4 3.029E-4 19 408
18 hsa-miR-1197:PITA hsa-miR-1197:PITA TOP PITA 2.307E-7 1.741E-5 1.367E-4 3.338E-4 13 188
19 hsa-miR-1:PITA hsa-miR-1:PITA TOP PITA 2.428E-7 1.741E-5 1.367E-4 3.513E-4 18 371
20 hsa-miR-206:PITA hsa-miR-206:PITA TOP PITA 2.428E-7 1.741E-5 1.367E-4 3.513E-4 18 371
21 hsa-miR-613:PITA hsa-miR-613:PITA TOP PITA 2.526E-7 1.741E-5 1.367E-4 3.655E-4 18 372
22 hsa-miR-1208:PITA hsa-miR-1208:PITA TOP PITA 3.932E-7 2.586E-5 2.031E-4 5.690E-4 16 304
23 miR-101:PicTar miR-101:PicTar PicTar 4.665E-7 2.935E-5 2.305E-4 6.751E-4 19 430
24 hsa-miR-320c:PITA hsa-miR-320c:PITA TOP PITA 5.998E-7 3.026E-5 2.377E-4 8.679E-4 20 481
25 hsa-miR-320a:PITA hsa-miR-320a:PITA TOP PITA 5.998E-7 3.026E-5 2.377E-4 8.679E-4 20 481
26 hsa-miR-320b:PITA hsa-miR-320b:PITA TOP PITA 5.998E-7 3.026E-5 2.377E-4 8.679E-4 20 481
27 hsa-miR-320d:PITA hsa-miR-320d:PITA TOP PITA 5.998E-7 3.026E-5 2.377E-4 8.679E-4 20 481
28 hsa-miR-107:PITA hsa-miR-107:PITA TOP PITA 6.065E-7 3.026E-5 2.377E-4 8.776E-4 18 395
29 hsa-miR-103:PITA hsa-miR-103:PITA TOP PITA 6.065E-7 3.026E-5 2.377E-4 8.776E-4 18 395
30 hsa-miR-421:PITA hsa-miR-421:PITA TOP PITA 6.356E-7 3.066E-5 2.408E-4 9.197E-4 17 355
31 miR-32:PicTar miR-32:PicTar PicTar 7.558E-7 3.528E-5 2.771E-4 1.094E-3 19 444
32 ACTGTGA,MIR-27B:MSigDB ACTGTGA,MIR-27B:MSigDB MSigDB 8.359E-7 3.665E-5 2.879E-4 1.210E-3 19 447
33 ACTGTGA,MIR-27A:MSigDB ACTGTGA,MIR-27A:MSigDB MSigDB 8.359E-7 3.665E-5 2.879E-4 1.210E-3 19 447
34 hsa-miR-491-3p:PITA hsa-miR-491-3p:PITA TOP PITA 9.998E-7 4.216E-5 3.312E-4 1.447E-3 15 287
35 hsa-miR-1264:PITA hsa-miR-1264:PITA TOP PITA 1.020E-6 4.216E-5 3.312E-4 1.476E-3 19 453
36 miR-92:PicTar miR-92:PicTar PicTar 1.151E-6 4.571E-5 3.591E-4 1.665E-3 18 413
37 hsa-miR-374a:TargetScan hsa-miR-374a:TargetScan TargetScan 1.201E-6 4.571E-5 3.591E-4 1.737E-3 19 458
38 hsa-miR-374b:TargetScan hsa-miR-374b:TargetScan TargetScan 1.201E-6 4.571E-5 3.591E-4 1.737E-3 19 458
39 hsa-miR-211:TargetScan hsa-miR-211:TargetScan TargetScan 1.322E-6 4.784E-5 3.758E-4 1.914E-3 19 461
40 hsa-miR-204:TargetScan hsa-miR-204:TargetScan TargetScan 1.322E-6 4.784E-5 3.758E-4 1.914E-3 19 461
41 hsa-miR-888:PITA hsa-miR-888:PITA TOP PITA 1.462E-6 5.159E-5 4.052E-4 2.115E-3 18 420
42 hsa-miR-892b:PITA hsa-miR-892b:PITA TOP PITA 1.528E-6 5.263E-5 4.134E-4 2.211E-3 13 222
43 hsa-miR-532-5p:PITA hsa-miR-532-5p:PITA TOP PITA 1.606E-6 5.405E-5 4.246E-4 2.324E-3 13 223
44 hsa-miR-191:TargetScan hsa-miR-191:TargetScan TargetScan 1.661E-6 5.462E-5 4.290E-4 2.403E-3 6 33
45 hsa-miR-603:PITA hsa-miR-603:PITA TOP PITA 1.932E-6 6.211E-5 4.879E-4 2.795E-3 17 385
46 hsa-miR-516b:PITA hsa-miR-516b:PITA TOP PITA 2.086E-6 6.560E-5 5.153E-4 3.018E-3 12 193
47 miR-144:PicTar miR-144:PicTar PicTar 2.249E-6 6.662E-5 5.233E-4 3.254E-3 18 433
48 hsa-miR-101:PITA hsa-miR-101:PITA TOP PITA 2.322E-6 6.662E-5 5.233E-4 3.360E-3 19 479
49 TGGTGCT,MIR-29A:MSigDB TGGTGCT,MIR-29A:MSigDB MSigDB 2.394E-6 6.662E-5 5.233E-4 3.464E-3 19 480
50 TGGTGCT,MIR-29C:MSigDB TGGTGCT,MIR-29C:MSigDB MSigDB 2.394E-6 6.662E-5 5.233E-4 3.464E-3 19 480
Show 45 more annotations

17: Drug [Display Chart] 22128 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C487081 belinostat CTD 7.302E-11 1.616E-6 1.710E-5 1.616E-6 23 417
2 C009618 O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate CTD 3.312E-10 3.665E-6 3.878E-5 7.330E-6 16 201
3 D012524 Sarin CTD 6.158E-9 4.542E-5 4.807E-4 1.363E-4 17 281
4 5280 UP Timolol maleate salt [26921-17-5]; Up 200; 9.2uM; MCF7; HT HG-U133A Broad Institute CMAP 1.624E-7 8.985E-4 9.508E-3 3.594E-3 13 199
5 4269 UP Norgestrel-(-)-D [797-63-7]; Up 200; 12.8uM; PC3; HT HG-U133A Broad Institute CMAP 8.774E-7 2.603E-3 2.754E-2 1.942E-2 12 194
6 4535 UP Parbendazole [14255-87-9]; Up 200; 16.2uM; PC3; HT HG-U133A Broad Institute CMAP 9.781E-7 2.603E-3 2.754E-2 2.164E-2 12 196
7 6779 UP Butirosin disulfate salt [51022-98-1]; Up 200; 5.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.089E-6 2.603E-3 2.754E-2 2.409E-2 12 198
8 266 DN (+/-)-thalidomide; Down 200; 100uM; MCF7; HG-U133A Broad Institute CMAP 1.089E-6 2.603E-3 2.754E-2 2.409E-2 12 198
9 CID000139506 Val-Ser Stitch 1.336E-6 2.603E-3 2.754E-2 2.955E-2 4 9
10 D010095 Oxotremorine CTD 1.336E-6 2.603E-3 2.754E-2 2.955E-2 4 9
11 CID005289285 Reidispongiolide C Stitch 1.388E-6 2.603E-3 2.754E-2 3.070E-2 14 280
12 CID000092427 maltolate Stitch 1.428E-6 2.603E-3 2.754E-2 3.159E-2 6 35
13 CID000023305 2-methylindoline Stitch 1.529E-6 2.603E-3 2.754E-2 3.384E-2 5 20
14 CID000001253 (+/-)-Huperzine A Stitch 1.698E-6 2.685E-3 2.841E-2 3.758E-2 6 36
15 CID003036508 Pc 12 Stitch 2.122E-6 3.130E-3 3.312E-2 4.695E-2 12 211
16 3993 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 2.411E-6 3.334E-3 3.528E-2
5.335E-2
 11 177
17 7074 UP MS-275; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 3.511E-6 4.570E-3 4.836E-2
7.769E-2
 11 184
18 CID000134312 BAPPs Stitch 4.303E-6 5.012E-3
5.303E-2
9.522E-2
 3 4
19 CID000107281 3-methyl-2,5-hexanedione Stitch 4.303E-6 5.012E-3
5.303E-2
9.522E-2
 3 4
20 4569 UP Novobiocin sodium salt [1476-53-5]; Up 200; 6.4uM; PC3; HT HG-U133A Broad Institute CMAP 5.555E-6 5.339E-3
5.649E-2
1.229E-1
 11 193
21 2711 DN Isoetharine mesylate salt [7279-75-6]; Down 200; 12uM; HL60; HT HG-U133A Broad Institute CMAP 5.836E-6 5.339E-3
5.649E-2
1.291E-1
 11 194
22 5440 UP Imipramine hydrochloride [113-52-0]; Up 200; 12.6uM; MCF7; HT HG-U133A Broad Institute CMAP 6.130E-6 5.339E-3
5.649E-2
1.356E-1
 11 195
23 4105 UP Fusaric acid [536-69-6]; Up 200; 22.4uM; MCF7; HT HG-U133A Broad Institute CMAP 6.436E-6 5.339E-3
5.649E-2
1.424E-1
 11 196
24 6475 UP Prazosin hydrochloride [19237-84-4]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP 6.755E-6 5.339E-3
5.649E-2
1.495E-1
 11 197
25 6062 UP Finasteride [98319-26-7]; Up 200; 10.8uM; MCF7; HT HG-U133A Broad Institute CMAP 6.755E-6 5.339E-3
5.649E-2
1.495E-1
 11 197
26 308 DN sulindac sulfide; Down 200; 50uM; MCF7; HG-U133A Broad Institute CMAP 6.755E-6 5.339E-3
5.649E-2
1.495E-1
 11 197
27 6126 UP Natamycin [7681-93-8]; Up 200; 6uM; HL60; HT HG-U133A Broad Institute CMAP 6.755E-6 5.339E-3
5.649E-2
1.495E-1
 11 197
28 3191 UP Quinidine hydrochloride monohydrate [6151-40-2]; Up 200; 10.6uM; MCF7; HT HG-U133A Broad Institute CMAP 6.755E-6 5.339E-3
5.649E-2
1.495E-1
 11 197
29 4717 UP Atractyloside potassium salt [102130-43-8]; Up 200; 5uM; MCF7; HT HG-U133A Broad Institute CMAP 7.089E-6 5.409E-3
5.724E-2
1.569E-1
 11 198
30 CID000062774 ammoniacal silver nitrate solution Stitch 1.068E-5 7.281E-3
7.704E-2
2.362E-1
 3 5
31 CID000147513 2-isopropylpentanoic acid Stitch 1.068E-5 7.281E-3
7.704E-2
2.362E-1
 3 5
32 4632 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.073E-5 7.281E-3
7.704E-2
2.374E-1
 10 169
33 CID005195771 1-phenylpentan-3-amine Stitch 1.086E-5 7.281E-3
7.704E-2
2.403E-1
 5 29
34 7387 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.606E-5 1.037E-2
1.097E-1
3.554E-1
 10 177
35 5940 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 1.687E-5 1.037E-2
1.097E-1
3.732E-1
 10 178
36 5065 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.687E-5 1.037E-2
1.097E-1
3.732E-1
 10 178
37 CID000445780 AC1L9IK6 Stitch 1.795E-5 1.061E-2
1.123E-1
3.973E-1
 5 32
38 C046243 tryptanthrine CTD 1.822E-5 1.061E-2
1.123E-1
4.033E-1
 4 16
39 CID000023229 1,3-diacetylbenzene Stitch 2.119E-5 1.144E-2
1.210E-1
4.689E-1
 3 6
40 CID000100657 diphenyl ditelluride Stitch 2.119E-5 1.144E-2
1.210E-1
4.689E-1
 3 6
41 CID000209654 Sv 2 Stitch 2.119E-5 1.144E-2
1.210E-1
4.689E-1
 3 6
42 2208 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP 2.702E-5 1.276E-2
1.351E-1
5.978E-1
 10 188
43 CID000005052 3-isoreserpine Stitch 2.958E-5 1.276E-2
1.351E-1
6.545E-1
 10 190
44 C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone CTD 3.044E-5 1.276E-2
1.351E-1
6.736E-1
 13 320
45 D016291 Dizocilpine Maleate CTD 3.054E-5 1.276E-2
1.351E-1
6.759E-1
 7 86
46 CID000003837 AC1L1GTT Stitch 3.238E-5 1.276E-2
1.351E-1
7.165E-1
 11 233
47 D012110 Reserpine CTD 3.334E-5 1.276E-2
1.351E-1
7.377E-1
 8 119
48 C035988 procymidone CTD 3.451E-5 1.276E-2
1.351E-1
7.637E-1
 9 155
49 4173 DN Carbenoxolone disodium salt [7421-40-1]; Down 200; 6.6uM; MCF7; HT HG-U133A Broad Institute CMAP 3.533E-5 1.276E-2
1.351E-1
7.817E-1
 10 194
50 C017690 fenvalerate CTD 3.546E-5 1.276E-2
1.351E-1
7.848E-1
 7 88
Show 45 more annotations

18: Disease [Display Chart] 2208 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0234133 Extrapyramidal sign DisGeNET BeFree 3.922E-8 8.659E-5 7.167E-4 8.659E-5 8 41
2 umls:C0338451 Frontotemporal dementia DisGeNET Curated 1.357E-6 1.498E-3 1.240E-2 2.997E-3 10 110
3 umls:C0017075 Ganglioneuroma DisGeNET BeFree 2.270E-6 1.671E-3 1.383E-2 5.013E-3 7 48
4 umls:C0236642 Pick Disease of the Brain DisGeNET Curated 3.285E-6 1.813E-3 1.501E-2 7.253E-3 9 95
5 umls:C0334576 Gliomatosis cerebri DisGeNET BeFree 1.077E-4 4.447E-2
3.681E-1
2.378E-1
 3 8
6 umls:C0010606 Adenoid Cystic Carcinoma DisGeNET Curated 1.284E-4 4.447E-2
3.681E-1
2.836E-1
 10 185
7 umls:C1843225 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2E (disorder) DisGeNET Curated 1.603E-4 4.447E-2
3.681E-1
3.541E-1
 2 2
8 umls:C0001973 Alcoholic Intoxication, Chronic DisGeNET Curated 1.822E-4 4.447E-2
3.681E-1
4.023E-1
 14 355
9 umls:C0206762 Limb Deformities, Congenital DisGeNET Curated 1.822E-4 4.447E-2
3.681E-1
4.024E-1
 5 42
10 umls:C0018817 Atrial Septal Defects DisGeNET Curated 2.106E-4 4.447E-2
3.681E-1
4.651E-1
 12 275
11 umls:C0026827 Muscle hypotonia DisGeNET Curated 2.396E-4 4.447E-2
3.681E-1
5.291E-1
 6 69
12 umls:C3539878 Triple Negative Breast Neoplasms DisGeNET BeFree 2.417E-4 4.447E-2
3.681E-1
5.336E-1
 16 456
13 umls:C0023465 Acute monocytic leukemia DisGeNET Curated 2.804E-4 4.762E-2
3.941E-1
6.190E-1
 6 71
14 umls:C2931189 Neural crest tumor DisGeNET Curated 3.085E-4 4.865E-2
4.027E-1
6.811E-1
 3 11
Show 9 more annotations