Toppgene analysis for aggregated_1964_log, IC23, negative side

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1: GO: Molecular Function [Display Chart] 242 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0061134 peptidase regulator activity 1.665E-4 2.843E-2
1.725E-1
 4.029E-2 5 223
2 GO:0019838 growth factor binding 3.337E-4 2.843E-2
1.725E-1
8.075E-2
 4 142
3 GO:0019003 GDP binding 3.538E-4 2.843E-2
1.725E-1
8.562E-2
 3 59
4 GO:0004866 endopeptidase inhibitor activity 6.729E-4 2.843E-2
1.725E-1
1.629E-1
 4 171
5 GO:0061135 endopeptidase regulator activity 7.656E-4 2.843E-2
1.725E-1
1.853E-1
 4 177
6 GO:0030414 peptidase inhibitor activity 8.151E-4 2.843E-2
1.725E-1
1.973E-1
 4 180
7 GO:0000146 microfilament motor activity 1.310E-3 2.843E-2
1.725E-1
3.170E-1
 2 23
8 GO:0004867 serine-type endopeptidase inhibitor activity 1.464E-3 2.843E-2
1.725E-1
3.543E-1
 3 96
9 GO:0005525 GTP binding 1.838E-3 2.843E-2
1.725E-1
4.448E-1
 5 379
10 GO:0005520 insulin-like growth factor binding 1.943E-3 2.843E-2
1.725E-1
4.702E-1
 2 28
11 GO:0004857 enzyme inhibitor activity 2.153E-3 2.843E-2
1.725E-1
5.210E-1
 5 393
12 GO:0032561 guanyl ribonucleotide binding 2.324E-3 2.843E-2
1.725E-1
5.625E-1
 5 400
13 GO:0033222 xylose binding 2.338E-3 2.843E-2
1.725E-1
5.658E-1
 1 1
14 GO:0031405 lipoic acid binding 2.338E-3 2.843E-2
1.725E-1
5.658E-1
 1 1
15 GO:0005009 insulin-activated receptor activity 2.338E-3 2.843E-2
1.725E-1
5.658E-1
 1 1
16 GO:0019809 spermidine binding 2.338E-3 2.843E-2
1.725E-1
5.658E-1
 1 1
17 GO:0033676 double-stranded DNA-dependent ATPase activity 2.338E-3 2.843E-2
1.725E-1
5.658E-1
 1 1
18 GO:0060001 minus-end directed microfilament motor activity 2.338E-3 2.843E-2
1.725E-1
5.658E-1
 1 1
19 GO:0070320 inward rectifier potassium channel inhibitor activity 2.338E-3 2.843E-2
1.725E-1
5.658E-1
 1 1
20 GO:0019001 guanyl nucleotide binding 2.350E-3 2.843E-2
1.725E-1
5.686E-1
 5 401
21 GO:0002114 interleukin-33 receptor activity 4.671E-3 4.914E-2
2.982E-1
1.000E0
 1 2
22 GO:0004145 diamine N-acetyltransferase activity 4.671E-3 4.914E-2
2.982E-1
1.000E0
 1 2
23 GO:0001179 RNA polymerase I transcription factor binding 4.671E-3 4.914E-2
2.982E-1
1.000E0
 1 2
Show 18 more annotations

2: GO: Biological Process [Display Chart] 1741 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway 1.606E-5 2.796E-2
2.248E-1
 2.796E-2 2 3
2 GO:0045629 negative regulation of T-helper 2 cell differentiation 5.338E-5 3.628E-2
2.917E-1
9.293E-2
 2 5
3 GO:0031952 regulation of protein autophosphorylation 1.386E-4 3.628E-2
2.917E-1
2.413E-1
 3 43
4 GO:0051607 defense response to virus 1.417E-4 3.628E-2
2.917E-1
2.467E-1
 6 344
5 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process 1.488E-4 3.628E-2
2.917E-1
2.591E-1
 2 8
6 GO:0045861 negative regulation of proteolysis 1.983E-4 3.628E-2
2.917E-1
3.453E-1
 6 366
7 GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process 2.384E-4 3.628E-2
2.917E-1
4.151E-1
 2 10
8 GO:0045071 negative regulation of viral genome replication 2.446E-4 3.628E-2
2.917E-1
4.258E-1
 3 52
9 GO:0010951 negative regulation of endopeptidase activity 2.598E-4 3.628E-2
2.917E-1
4.523E-1
 5 245
10 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 2.909E-4 3.628E-2
2.917E-1
5.064E-1
 6 393
11 GO:0010466 negative regulation of peptidase activity 3.238E-4 3.628E-2
2.917E-1
5.637E-1
 5 257
12 GO:0002829 negative regulation of type 2 immune response 3.487E-4 3.628E-2
2.917E-1
6.070E-1
 2 12
13 GO:0060546 negative regulation of necroptotic process 3.487E-4 3.628E-2
2.917E-1
6.070E-1
 2 12
14 GO:0045628 regulation of T-helper 2 cell differentiation 3.487E-4 3.628E-2
2.917E-1
6.070E-1
 2 12
15 GO:0045623 negative regulation of T-helper cell differentiation 3.487E-4 3.628E-2
2.917E-1
6.070E-1
 2 12
16 GO:0052547 regulation of peptidase activity 3.940E-4 3.628E-2
2.917E-1
6.859E-1
 6 416
17 GO:0051346 negative regulation of hydrolase activity 4.093E-4 3.628E-2
2.917E-1
7.125E-1
 6 419
18 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 4.114E-4 3.628E-2
2.917E-1
7.163E-1
 2 13
19 GO:0010498 proteasomal protein catabolic process 4.251E-4 3.628E-2
2.917E-1
7.400E-1
 6 422
20 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 4.569E-4 3.628E-2
2.917E-1
7.955E-1
 4 154
21 GO:0009615 response to virus 4.695E-4 3.628E-2
2.917E-1
8.174E-1
 6 430
22 GO:0060544 regulation of necroptotic process 4.793E-4 3.628E-2
2.917E-1
8.344E-1
 2 14
23 GO:1904294 positive regulation of ERAD pathway 4.793E-4 3.628E-2
2.917E-1
8.344E-1
 2 14
24 GO:0046639 negative regulation of alpha-beta T cell differentiation 6.301E-4 4.220E-2
3.392E-1
1.000E0
 2 16
25 GO:0060547 negative regulation of necrotic cell death 6.301E-4 4.220E-2
3.392E-1
1.000E0
 2 16
26 GO:0045064 T-helper 2 cell differentiation 6.301E-4 4.220E-2
3.392E-1
1.000E0
 2 16
Show 21 more annotations

3: GO: Cellular Component [Display Chart] 170 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001726 ruffle 4.125E-5 7.012E-3 4.008E-2 7.012E-3 5 169
2 GO:0045121 membrane raft 1.249E-4 7.076E-3 4.045E-2 2.123E-2 6 343
3 GO:0098857 membrane microdomain 1.249E-4 7.076E-3 4.045E-2 2.123E-2 6 343
4 GO:0010008 endosome membrane 2.830E-4 1.203E-2
6.874E-2
 4.811E-2 6 399
5 GO:0044440 endosomal part 4.429E-4 1.506E-2
8.607E-2
7.529E-2
 6 434
6 GO:0030667 secretory granule membrane 1.116E-3 2.623E-2
1.499E-1
1.897E-1
 3 89
7 GO:0098858 actin-based cell projection 1.255E-3 2.623E-2
1.499E-1
2.134E-1
 4 206
8 GO:0002080 acrosomal membrane 1.376E-3 2.623E-2
1.499E-1
2.339E-1
 2 24
9 GO:0005901 caveola 1.389E-3 2.623E-2
1.499E-1
2.361E-1
 3 96
10 GO:0044853 plasma membrane raft 1.796E-3 2.936E-2
1.678E-1
3.053E-1
 3 105
11 GO:0031252 cell leading edge 1.899E-3 2.936E-2
1.678E-1
3.229E-1
 5 389
12 GO:0031901 early endosome membrane 2.271E-3 3.093E-2
1.768E-1
3.860E-1
 3 114
13 GO:0061695 transferase complex, transferring phosphorus-containing groups 2.365E-3 3.093E-2
1.768E-1
4.021E-1
 4 245
14 GO:0030139 endocytic vesicle 3.181E-3 3.862E-2
2.208E-1
5.407E-1
 4 266
15 GO:1990037 Lewy body core 4.585E-3 4.585E-2
2.621E-1
7.794E-1
 1 2
16 GO:0016035 zeta DNA polymerase complex 4.585E-3 4.585E-2
2.621E-1
7.794E-1
 1 2
17 GO:0098559 cytoplasmic side of early endosome membrane 4.585E-3 4.585E-2
2.621E-1
7.794E-1
 1 2
Show 12 more annotations

4: Human Phenotype [Display Chart] 174 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000956 Acanthosis nigricans 8.469E-4 3.770E-2
2.164E-1
1.474E-1
 2 18
2 HP:0000519 Congenital cataract 9.513E-4 3.770E-2
2.164E-1
1.655E-1
 3 83
3 HP:0001620 High pitched voice {has synonym type="layperson"} 1.272E-3 3.770E-2
2.164E-1
2.213E-1
 2 22
4 HP:0002901 Hypocalcemia 1.780E-3 3.770E-2
2.164E-1
3.096E-1
 2 26
5 HP:0100253 Abnormality of the medullary cavity of the long bones 2.494E-3 3.770E-2
2.164E-1
4.340E-1
 1 1
6 HP:0012762 Cerebral white matter atrophy 2.494E-3 3.770E-2
2.164E-1
4.340E-1
 1 1
7 HP:0007409 Absence of subcutaneous fat over entire body except buttocks, hips, and thighs 2.494E-3 3.770E-2
2.164E-1
4.340E-1
 1 1
8 HP:0008283 Fasting hyperinsulinemia 2.494E-3 3.770E-2
2.164E-1
4.340E-1
 1 1
9 HP:0008285 Transient hypophosphatemia 2.494E-3 3.770E-2
2.164E-1
4.340E-1
 1 1
10 HP:0030147 Truncal titubation 2.494E-3 3.770E-2
2.164E-1
4.340E-1
 1 1
11 HP:0000212 Gingival overgrowth 2.864E-3 3.770E-2
2.164E-1
4.983E-1
 2 33
12 HP:0000958 Dry skin {has synonym type="layperson"} 4.399E-3 3.770E-2
2.164E-1
7.654E-1
 2 41
13 HP:0007340 Lower limb muscle weakness {has synonym type="layperson"} 4.831E-3 3.770E-2
2.164E-1
8.406E-1
 2 43
14 HP:0005202 Helicobacter pylori infection 4.983E-3 3.770E-2
2.164E-1
8.670E-1
 1 2
15 HP:0011998 Postprandial hyperglycemia 4.983E-3 3.770E-2
2.164E-1
8.670E-1
 1 2
16 HP:0007862 Retinal calcification 4.983E-3 3.770E-2
2.164E-1
8.670E-1
 1 2
17 HP:0004405 Prominent nipples {has synonym type="layperson"} 4.983E-3 3.770E-2
2.164E-1
8.670E-1
 1 2
18 HP:0006288 Advanced eruption of teeth 4.983E-3 3.770E-2
2.164E-1
8.670E-1
 1 2
19 HP:0030054 Perifollicular fibrosis 4.983E-3 3.770E-2
2.164E-1
8.670E-1
 1 2
20 HP:0012542 Onychauxis 4.983E-3 3.770E-2
2.164E-1
8.670E-1
 1 2
21 HP:0006270 Hypoplastic spleen 4.983E-3 3.770E-2
2.164E-1
8.670E-1
 1 2
22 HP:0010296 Ankyloglossia 4.983E-3 3.770E-2
2.164E-1
8.670E-1
 1 2
23 HP:0004428 Elfin facies 4.983E-3 3.770E-2
2.164E-1
8.670E-1
 1 2
24 HP:0005317 Increased pulmonary vascular resistance 7.466E-3 4.996E-2
2.868E-1
1.000E0
 1 3
25 HP:0001953 Diabetic ketoacidosis 7.466E-3 4.996E-2
2.868E-1
1.000E0
 1 3
26 HP:0007210 Lower limb amyotrophy 7.466E-3 4.996E-2
2.868E-1
1.000E0
 1 3
Show 21 more annotations

5: Mouse Phenotype [Display Chart] 1282 annotations before applied cutoff / 9299 genes in category

No results to display

6: Domain [Display Chart] 320 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR008971 HSP40/DnaJ pept-bd InterPro 1.834E-4 1.956E-2
1.241E-1
5.867E-2
 2 9
2 IPR002939 DnaJ C InterPro 1.834E-4 1.956E-2
1.241E-1
5.867E-2
 2 9
3 PF01556 DnaJ C Pfam 1.834E-4 1.956E-2
1.241E-1
5.867E-2
 2 9
4 IPR001806 Small GTPase InterPro 4.878E-4 2.623E-2
1.665E-1
1.561E-1
 4 160
5 IPR005225 Small GTP-bd dom InterPro 5.732E-4 2.623E-2
1.665E-1
1.834E-1
 4 167
6 IPR018253 DnaJ domain CS InterPro 1.741E-3 2.623E-2
1.665E-1
5.573E-1
 2 27
7 IPR029546 PEA15 InterPro 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
8 PF16735 MYO10 CC Pfam 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
9 IPR002388 AnnexinI InterPro 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
10 PS51252 ANTISTASIN PROSITE 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
11 PF08221 HTH 9 Pfam 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
12 IPR032412 Myosin-VI CBD InterPro 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
13 IPR019341 Alpha/Gamma-adaptin-bd p34 InterPro 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
14 IPR028482 S100A11 InterPro 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
15 IPR029864 TFPI1 InterPro 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
16 IPR008806 RNA pol III Rpc82 C InterPro 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
17 IPR028795 C-IAP1 InterPro 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
18 IPR013197 RNA pol III RPC82-rel HTH InterPro 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
19 PF10199 Adaptin binding Pfam 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
20 2.10.22.10 - Gene3D 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
21 PF16521 Myosin-VI CBD Pfam 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
22 PF05645 RNA pol Rpc82 Pfam 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
23 PF02822 Antistasin Pfam 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
24 IPR004094 Antistasin-like InterPro 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
25 IPR027241 Rcn1 InterPro 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
26 IPR032957 SAT1 InterPro 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
27 IPR015504 CAV-1 InterPro 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
28 IPR031971 MYO10 CC InterPro 2.295E-3 2.623E-2
1.665E-1
7.345E-1
 1 1
29 PF00788 RA Pfam 3.085E-3 2.935E-2
1.863E-1
9.872E-1
 2 36
30 IPR001609 Myosin head motor dom InterPro 3.433E-3 2.935E-2
1.863E-1
1.000E0
 2 38
31 SM00242 MYSc SMART 3.433E-3 2.935E-2
1.863E-1
1.000E0
 2 38
32 PS51456 MYOSIN MOTOR PROSITE 3.433E-3 2.935E-2
1.863E-1
1.000E0
 2 38
33 PF00063 Myosin head Pfam 3.433E-3 2.935E-2
1.863E-1
1.000E0
 2 38
34 PF00071 Ras Pfam 3.735E-3 2.935E-2
1.863E-1
1.000E0
 3 136
35 IPR000159 RA dom InterPro 3.797E-3 2.935E-2
1.863E-1
1.000E0
 2 40
36 PF15273 NHS Pfam 4.585E-3 2.935E-2
1.863E-1
1.000E0
 1 2
37 SM00507 HNHc SMART 4.585E-3 2.935E-2
1.863E-1
1.000E0
 1 2
38 IPR002945 Glc transpt 3 InterPro 4.585E-3 2.935E-2
1.863E-1
1.000E0
 1 2
39 IPR024845 NHS fam InterPro 4.585E-3 2.935E-2
1.863E-1
1.000E0
 1 2
40 PF09790 Hyccin Pfam 4.585E-3 2.935E-2
1.863E-1
1.000E0
 1 2
41 IPR007701 Interferon-rel develop reg N InterPro 4.585E-3 2.935E-2
1.863E-1
1.000E0
 1 2
42 IPR008364 Paraoxonase2 InterPro 4.585E-3 2.935E-2
1.863E-1
1.000E0
 1 2
43 IPR007635 Tis11B N InterPro 4.585E-3 2.935E-2
1.863E-1
1.000E0
 1 2
44 IPR006782 PDGF N InterPro 4.585E-3 2.935E-2
1.863E-1
1.000E0
 1 2
45 PF04553 Tis11B N Pfam 4.585E-3 2.935E-2
1.863E-1
1.000E0
 1 2
46 PF04836 IFRD C Pfam 4.585E-3 2.935E-2
1.863E-1
1.000E0
 1 2
47 PF04692 PDGF N Pfam 4.585E-3 2.935E-2
1.863E-1
1.000E0
 1 2
48 IPR006921 Interferon-rel develop reg C InterPro 4.585E-3 2.935E-2
1.863E-1
1.000E0
 1 2
49 PF05004 IFRD Pfam 4.585E-3 2.935E-2
1.863E-1
1.000E0
 1 2
50 IPR018619 Hyccin InterPro 4.585E-3 2.935E-2
1.863E-1
1.000E0
 1 2
Show 45 more annotations

7: Pathway [Display Chart] 338 annotations before applied cutoff / 10916 genes in category

No results to display

8: Pubmed [Display Chart] 6777 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 8557678 Calcium-dependent binding of S100C to the N-terminal domain of annexin I. Pubmed 7.037E-7 3.974E-4 3.735E-3 4.769E-3 2 2
2 17699617:gr Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance. GeneRIF 7.037E-7 3.974E-4 3.735E-3 4.769E-3 2 2
3 12645011 Subcellular localization of S100A11 (S100C) in LLC-PK1 renal cells: Calcium- and protein kinase c-dependent association of S100A11 with S100B and vimentin intermediate filaments. Pubmed 7.037E-7 3.974E-4 3.735E-3 4.769E-3 2 2
4 15817451:gr Caveolin-1 enhances tissue factor pathway inhibitor exposure and function on the cell surface. GeneRIF 7.037E-7 3.974E-4 3.735E-3 4.769E-3 2 2
5 12036959:gr The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1. GeneRIF 7.037E-7 3.974E-4 3.735E-3 4.769E-3 2 2
6 22706202 Caveolin-1 increases aerobic glycolysis in colorectal cancers by stimulating HMGA1-mediated GLUT3 transcription. Pubmed 7.037E-7 3.974E-4 3.735E-3 4.769E-3 2 2
7 24659799 Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion. Pubmed 7.037E-7 3.974E-4 3.735E-3 4.769E-3 2 2
8 15817451 Caveolin-1 enhances tissue factor pathway inhibitor exposure and function on the cell surface. Pubmed 7.037E-7 3.974E-4 3.735E-3 4.769E-3 2 2
9 10598578 Caveolin-1 interacts with the insulin receptor and can differentially modulate insulin signaling in transfected Cos-7 cells and rat adipose cells. Pubmed 7.037E-7 3.974E-4 3.735E-3 4.769E-3 2 2
10 17932043:gr Truncation of annexin A1 is a regulatory lever for linking epidermal growth factor signaling with cytosolic phospholipase A2 in normal and malignant squamous epithelial cells. GeneRIF 7.037E-7 3.974E-4 3.735E-3 4.769E-3 2 2
11 22706202:gr Caveolin-1 increases aerobic glycolysis in colorectal cancers by stimulating HMGA1-mediated GLUT3 transcription. GeneRIF 7.037E-7 3.974E-4 3.735E-3 4.769E-3 2 2
12 17932043 Truncation of annexin A1 is a regulatory lever for linking epidermal growth factor signaling with cytosolic phospholipase A2 in normal and malignant squamous epithelial cells. Pubmed 7.037E-7 3.974E-4 3.735E-3 4.769E-3 2 2
13 19406948:gr Caveolin-1 loss of function accelerates glucose transporter 4 and insulin receptor degradation in 3T3-L1 adipocytes. GeneRIF 2.110E-6 1.100E-3 1.034E-2 1.430E-2 2 3
14 19219452:gr Caveolin, GLUT4 and insulin receptor protein content in human arm and leg muscles. GeneRIF 4.218E-6 1.906E-3 1.791E-2 2.858E-2 2 4
15 19219452 Caveolin, GLUT4 and insulin receptor protein content in human arm and leg muscles. Pubmed 4.218E-6 1.906E-3 1.791E-2 2.858E-2 2 4
16 11733506 A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. Pubmed 7.026E-6 2.201E-3 2.068E-2 4.761E-2 2 5
17 22952906 Dynamin- and Rab5-dependent endocytosis of a Ca2+ -activated K+ channel, KCa2.3. Pubmed 7.026E-6 2.201E-3 2.068E-2 4.761E-2 2 5
18 12147258 Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin. Pubmed 7.026E-6 2.201E-3 2.068E-2 4.761E-2 2 5
19 9741627 A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Pubmed 7.026E-6 2.201E-3 2.068E-2 4.761E-2 2 5
20 12972505 RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway. Pubmed 1.053E-5 2.201E-3 2.068E-2
7.138E-2
 2 6
21 18767904 Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. Pubmed 1.474E-5 2.201E-3 2.068E-2
9.988E-2
 2 7
22 24318877 Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. Pubmed 2.524E-5 2.201E-3 2.068E-2
1.710E-1
 2 9
23 16890161 Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Pubmed 3.153E-5 2.201E-3 2.068E-2
2.137E-1
 2 10
24 20730440 Genetic factors responsible for long bone fractures non-union. Pubmed 3.852E-5 2.201E-3 2.068E-2
2.610E-1
 2 11
25 20730440:gr Genetic factors responsible for long bone fractures non-union. GeneRIF 3.852E-5 2.201E-3 2.068E-2
2.610E-1
 2 11
26 19948975:gr Integrative predictive model of coronary artery calcification in atherosclerosis. GeneRIF 4.379E-5 2.201E-3 2.068E-2
2.967E-1
 4 229
27 19948975 Integrative predictive model of coronary artery calcification in atherosclerosis. Pubmed 4.379E-5 2.201E-3 2.068E-2
2.967E-1
 4 229
28 25468996 E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Pubmed 1.357E-4 2.201E-3 2.068E-2
9.197E-1
 4 307
29 21231916 The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. Pubmed 1.760E-4 2.201E-3 2.068E-2
1.000E0
 2 23
30 23085658 c-IAP1 binds and processes PCSK9 protein: linking the c-IAP1 in a TNF-¿ pathway to PCSK9-mediated LDLR degradation pathway. Pubmed 1.919E-4 2.201E-3 2.068E-2
1.000E0
 2 24
31 18676680 Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. Pubmed 3.088E-4 2.201E-3 2.068E-2
1.000E0
 4 381
32 18676680:gr Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. GeneRIF 3.088E-4 2.201E-3 2.068E-2
1.000E0
 4 381
33 19170196 Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. Pubmed 3.150E-4 2.201E-3 2.068E-2
1.000E0
 4 383
34 19170196:gr Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. GeneRIF 3.150E-4 2.201E-3 2.068E-2
1.000E0
 4 383
35 11147971 Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. Pubmed 4.113E-4 2.201E-3 2.068E-2
1.000E0
 2 35
36 19692168 Genetic susceptibility to distinct bladder cancer subphenotypes. Pubmed 4.539E-4 2.201E-3 2.068E-2
1.000E0
 4 422
37 19692168:gr Genetic susceptibility to distinct bladder cancer subphenotypes. GeneRIF 4.539E-4 2.201E-3 2.068E-2
1.000E0
 4 422
38 20936779 A human MAP kinase interactome. Pubmed 7.691E-4 2.201E-3 2.068E-2
1.000E0
 4 486
39 19167335 Large-scale structural analysis of the classical human protein tyrosine phosphatome. Pubmed 7.743E-4 2.201E-3 2.068E-2
1.000E0
 2 48
40 22252783:gr Transcriptional regulation of the GLAST/EAAT-1 gene in rat and man. GeneRIF 8.486E-4 2.201E-3 2.068E-2
1.000E0
 1 1
41 22733500 BIRC2 amplification in squamous cell carcinomas of the uterine cervix. Pubmed 8.486E-4 2.201E-3 2.068E-2
1.000E0
 1 1
42 10570961:gr Hsc40, a new member of the hsp40 family, exhibits similar expression profile to that of hsc70 in mammalian cells. GeneRIF 8.486E-4 2.201E-3 2.068E-2
1.000E0
 1 1
43 19788048:gr Homocysteine-induced endoplasmic reticulum protein (herp) is up-regulated in parkinsonian substantia nigra and present in the core of Lewy bodies. GeneRIF 8.486E-4 2.201E-3 2.068E-2
1.000E0
 1 1
44 22660985:gr A novel binding protein of single-minded 2: the mitotic arrest-deficient protein MAD2B. GeneRIF 8.486E-4 2.201E-3 2.068E-2
1.000E0
 1 1
45 21300347 Replication of association of a novel insulin receptor gene polymorphism with polycystic ovary syndrome. Pubmed 8.486E-4 2.201E-3 2.068E-2
1.000E0
 1 1
46 18054388:gr The immunogenic CBD1 peptide corresponding to the caveolin-1 binding domain in HIV-1 envelope gp41 has the capacity to penetrate the cell membrane and bind caveolin-1. GeneRIF 8.486E-4 2.201E-3 2.068E-2
1.000E0
 1 1
47 18691157 Protective effect of paraoxonase-2 against endoplasmic reticulum stress-induced apoptosis is lost upon disturbance of calcium homoeostasis. Pubmed 8.486E-4 2.201E-3 2.068E-2
1.000E0
 1 1
48 23813952 Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells. Pubmed 8.486E-4 2.201E-3 2.068E-2
1.000E0
 1 1
49 17197700:gr Identification of the HIV-1 gp41 core-binding motif in the scaffolding domain of caveolin-1. GeneRIF 8.486E-4 2.201E-3 2.068E-2
1.000E0
 1 1
50 25238264 Intracellular and extracellular domains of protein tyrosine phosphatase PTPRZ-B differentially regulate glioma cell growth and motility. Pubmed 8.486E-4 2.201E-3 2.068E-2
1.000E0
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 1318 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:TOLLIP TOLLIP interactions 6.559E-5 4.530E-2
3.516E-1
8.645E-2
 4 82
2 int:CERS5 CERS5 interactions 1.031E-4 4.530E-2
3.516E-1
1.359E-1
 2 6
3 int:KCNN3 KCNN3 interactions 1.031E-4 4.530E-2
3.516E-1
1.359E-1
 2 6

10: Cytoband [Display Chart] 42 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7q31.1 7q31.1 3.917E-4 1.333E-2
5.767E-2
 1.645E-2 2 23
2 15q22.33-q23 15q22.33-q23 1.269E-3 1.333E-2
5.767E-2
5.332E-2
 1 1
3 5p15.1-p14.3 5p15.1-p14.3 1.269E-3 1.333E-2
5.767E-2
5.332E-2
 1 1
4 3q23-q24 3q23-q24 1.269E-3 1.333E-2
5.767E-2
5.332E-2
 1 1
5 3p24-p22 3p24-p22 2.537E-3 1.776E-2
7.685E-2
1.066E-1
 1 2
6 14q22-q24 14q22-q24 2.537E-3 1.776E-2
7.685E-2
1.066E-1
 1 2
7 1q21.1 1q21.1 5.021E-3 2.661E-2
1.151E-1
2.109E-1
 2 83
8 22q13.1-q13.2 22q13.1-q13.2 5.068E-3 2.661E-2
1.151E-1
2.129E-1
 1 4
9 Xp22.1 Xp22.1 8.853E-3 4.131E-2
1.788E-1
3.718E-1
 1 7
10 20p11.22 20p11.22 1.137E-2 4.775E-2
2.066E-1
4.775E-1
 1 9
11 11q22 11q22 1.388E-2 4.857E-2
2.102E-1
5.829E-1
 1 11
12 18p11.3 18p11.3 1.388E-2 4.857E-2
2.102E-1
5.829E-1
 1 11
13 19p13.3-p13.2 19p13.3-p13.2 1.763E-2 4.936E-2
2.136E-1
7.404E-1
 1 14
14 2q32 2q32 1.763E-2 4.936E-2
2.136E-1
7.404E-1
 1 14
15 3q25.2 3q25.2 1.763E-2 4.936E-2
2.136E-1
7.404E-1
 1 14
16 7q31.3 7q31.3 1.888E-2 4.955E-2
2.144E-1
7.928E-1
 1 15
17 6p25 6p25 2.012E-2 4.972E-2
2.151E-1
8.452E-1
 1 16
18 5p13 5p13 2.137E-2 4.986E-2
2.157E-1
8.974E-1
 1 17
19 18q12.2 18q12.2 2.261E-2 4.998E-2
2.163E-1
9.496E-1
 1 18
Show 14 more annotations

11: Transcription Factor Binding Site [Display Chart] 237 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 39 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1104 Pleckstrin homology domain containing|Myosins, class X|FERM domain containing genenames.org 1.759E-3 3.430E-2
1.459E-1
6.859E-2
 1 1
2 1101 Myosins, class VI|Deafness associated genes genenames.org 1.759E-3 3.430E-2
1.459E-1
6.859E-2
 1 1
3 584 DNAJ (HSP40) heat shock proteins|C2 tensin-type domain containing genenames.org 3.347E-3 4.351E-2
1.851E-1
1.305E-1
 2 49
4 463 Paraoxonases genenames.org 5.267E-3 4.538E-2
1.930E-1
2.054E-1
 1 3
5 388 RAB, member RAS oncogene GTPases genenames.org 5.818E-3 4.538E-2
1.930E-1
2.269E-1
 2 65

13: Coexpression [Display Chart] 4064 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M16336 Up-regulated genes in MM1.S cells (multiple myeloma) treated with adaphostin [PubChem=387042], a tyrosine kinase inhibitor with anticancer properties. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.973E-10 2.021E-6 1.796E-5 2.021E-6 8 147
2 M4945 Genes up-regulated in comparison of monocytes versus plasmacytoid dendritic cells (pDC). MSigDB C7: Immunologic Signatures (v5.1) 5.689E-9 7.707E-6 6.849E-5 2.312E-5 8 200
3 M4971 Genes down-regulated in comparison of plasmacytoid dendritic cells (DC) from influenza vaccinee at day 7 post-vaccination versus myeloid DCs at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v5.1) 5.689E-9 7.707E-6 6.849E-5 2.312E-5 8 200
4 M6354 Genes down-regulated in gamma delta T cells stimulated by LPS: Vd1 versus Vd2. MSigDB C7: Immunologic Signatures (v5.1) 1.387E-7 1.127E-4 1.002E-3 5.636E-4 7 200
5 M4952 Genes down-regulated in comparison of plasmacytoid dendritic cells (DC) versus myeloid DCs. MSigDB C7: Immunologic Signatures (v5.1) 1.387E-7 1.127E-4 1.002E-3 5.636E-4 7 200
6 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.752E-7 1.864E-4 1.657E-3 1.118E-3 9 460
7 M4716 Genes up-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402], a protease inhibitor causing apoptosis. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.634E-7 2.691E-4 2.391E-3 1.883E-3 7 239
8 M11298 Genes up-regulated in EVSA-T cells (breast cancer) treated THC (delta-9-tetrahydrocannabinol) [PubChem=6610319]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.590E-7 2.840E-4 2.524E-3 2.272E-3 4 33
9 M17079 Up-regulated genes distinguishing between two subtypes of gastric cancer: advanced (AGC) and early (EGC). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.323E-6 5.972E-4 5.307E-3 5.375E-3 6 175
10 M2816 Genes up-regulated in CD34+ hematopoietic progenitor cells after knockdown of RPS14 [Gene ID=6208] by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 2.266E-6 8.331E-4 7.404E-3 9.210E-3 6 192
11 M6484 Genes up-regulated in monocyte-derived dendritic cells: untreated versus LPS and LPS like antigen from O. planktothrix (3h). MSigDB C7: Immunologic Signatures (v5.1) 2.788E-6 8.331E-4 7.404E-3 1.133E-2 6 199
12 M6600 Genes up-regulated in bone marrow-derived macrophages: untreated (0 min) versus LPS (180 min). MSigDB C7: Immunologic Signatures (v5.1) 2.870E-6 8.331E-4 7.404E-3 1.166E-2 6 200
13 M5787 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with type 1 diabetes at the time of the diagnosis versus those at 4 months later. MSigDB C7: Immunologic Signatures (v5.1) 2.870E-6 8.331E-4 7.404E-3 1.166E-2 6 200
14 M4963 Genes up-regulated in comparison of monocytes from influenza vaccinee at day 7 post-vaccination versus plasmacytoid dendritic cells (mDC) at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v5.1) 2.870E-6 8.331E-4 7.404E-3 1.166E-2 6 200
15 M863 Myb-regulated genes in MCF7 (breast cancer) and lung epithelial cell lines overexpressing MYBL2, MYBL1 or MYB [GeneID=4605;4603;4602]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.110E-6 8.426E-4 7.488E-3 1.264E-2 7 318
16 M12338 Genes changed in NIH 3T3 cells (embryonic fibroblast) by expression of one or more of C/EBP proteins: CEBPA, CEBPB, CEBPG, and CEBPD [GeneID=1050;1051;1054;1052]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.320E-6 1.351E-3 1.201E-2 2.162E-2 5 126
17 M15193 Genes up-regulated in pancreatic ductal adenocarcinoma (PDAC) identified in a meta analysis across four independent studies. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.766E-6 1.617E-3 1.437E-2 2.750E-2 7 358
18 M9016 Genes down-regulated in polysomal and total RNA samples from SW480 cells (primary colorectal carcinoma, CRC) compared to the SW620 cells (lymph node metastasis from the same individual). MSigDB C2: CGP Curated Gene Sets (v5.1) 7.725E-6 1.708E-3 1.518E-2 3.139E-2 5 136
19 M9945 Genes down-regulated in HeLa cells after knockdown of MED1 [GeneID=5469] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.984E-6 1.708E-3 1.518E-2 3.245E-2 6 239
20 M5547 Age up-regulated genes in the human frontal cortex. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.346E-5 2.733E-3 2.429E-2
5.471E-2
 6 262
21 M11513 Genes down-regulated in MCF10A cells (breast cancer) grown at low (mesenchymal phenotype) compared to those grown at high (epithelial, basal-like phenotype) confluency. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.412E-5 2.733E-3 2.429E-2
5.740E-2
 5 154
22 M5902 Genes mediating programmed cell death (apoptosis) by activation of caspases. MSigDB H: Hallmark Gene Sets (v5.1) 1.751E-5 3.234E-3 2.874E-2
7.115E-2
 5 161
23 M8857 Genes up-regulated in UB27 cells (osteosarcoma) at 8 hr after inducing the expression of a mutant form of WT1 [GeneID=7490]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.914E-5 3.381E-3 3.005E-2
7.777E-2
 5 164
24 M3015 Genes whose expression positively correlated with sensitivity of breast cancer cell lines to dasatinib [PubChem=3062316]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.017E-5 3.415E-3 3.035E-2
8.197E-2
 4 80
25 M1448 Genes up-regulated in RAW 264.7 cells (macrophage) 3 hr after stimulation with bacterial lipopolysaccharide (LPS). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.939E-5 3.591E-3 3.191E-2
1.195E-1
 4 88
26 M6753 Genes up-regulated in P493-6 cells (B lymphocyte, Burkitt's lymphoma model) upon knockdown of TFRC [GeneID=7037] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.960E-5 3.591E-3 3.191E-2
1.203E-1
 7 450
27 M17859 Genes down-regulated in UB27 cells (osteosarcoma) at any time point after inducing the expression of a mutant form of WT1 [GeneID=7490]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.358E-5 3.591E-3 3.191E-2
1.365E-1
 7 459
28 M4785 Genes down-regulated in monocyte-derived dendritic cells (MDDC) after stimulation with galecin-1 (lectin, LGALS1) [GeneID=3956] compared to that with bacterial lipopolysaccharide (LPS). MSigDB C2: CGP Curated Gene Sets (v5.1) 3.548E-5 3.591E-3 3.191E-2
1.442E-1
 7 463
29 M14151 Genes up-regulated in HEK293 cells (embryonic kidney) at 6 h, 12 h or 24 h after infection with reovirus strain T3A (known as a strong inducer of apoptosis). MSigDB C2: CGP Curated Gene Sets (v5.1) 3.727E-5 3.591E-3 3.191E-2
1.515E-1
 6 314
30 M2630 Genes down-regulated in mouse fibroblasts over-expressing E2F1 [Gene ID=1869] gene. MSigDB C6: Oncogenic Signatures (v5.1) 4.074E-5 3.591E-3 3.191E-2
1.656E-1
 5 192
31 M3898 Genes down-regulated in NHEK cells (normal epidermal keratinocytes) after UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.762E-5 3.591E-3 3.191E-2
1.935E-1
 7 485
32 M5293 Genes up-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from young donors versus those treated with TSST at 72 h. MSigDB C7: Immunologic Signatures (v5.1) 4.831E-5 3.591E-3 3.191E-2
1.963E-1
 5 199
33 M3119 Genes down-regulated in comparison of naive T cells versus memory T cells. MSigDB C7: Immunologic Signatures (v5.1) 4.831E-5 3.591E-3 3.191E-2
1.963E-1
 5 199
34 GSE19772 CTRL VS HCMV INF MONOCYTES UP Genes up-regulated in monocytes: control versus HCMV infection. MSigDB C7: Immunologic Signatures (v5.1) 4.831E-5 3.591E-3 3.191E-2
1.963E-1
 5 199
35 M5043 Genes down-regulated in comparison of splenic primary CD8 effector T cells at day 8 post-acute infection versus splenic secondary CD8 effector T cells at day 8 post-acute infection. MSigDB C7: Immunologic Signatures (v5.1) 4.831E-5 3.591E-3 3.191E-2
1.963E-1
 5 199
36 M5211 Genes up-regulated in comparison of dendritic cells (DC) exposed to L. major versus DCs exposed to 5 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v5.1) 4.948E-5 3.591E-3 3.191E-2
2.011E-1
 5 200
37 GSE20198 IL12 VS IL12 IL18 TREATED ACT CD4 TCELL UP Genes up-regulated in the activated CD4 [GeneID=920] T cells (48h): IL-12 versus IL-12 and IL18 [GeneID=3606]. MSigDB C7: Immunologic Signatures (v5.1) 4.948E-5 3.591E-3 3.191E-2
2.011E-1
 5 200
38 M5750 Genes down-regulated in comparison of thymus conventional T cells versus fat tissue conventional T cells. MSigDB C7: Immunologic Signatures (v5.1) 4.948E-5 3.591E-3 3.191E-2
2.011E-1
 5 200
39 M4938 Genes down-regulated in comparison of B cells versus monocytes. MSigDB C7: Immunologic Signatures (v5.1) 4.948E-5 3.591E-3 3.191E-2
2.011E-1
 5 200
40 M5059 Genes down-regulated in comparison of CD4- [GeneID=920] CD8- thymocytes versus CD4+ [GeneID=920] CD8- thymocytes. MSigDB C7: Immunologic Signatures (v5.1) 4.948E-5 3.591E-3 3.191E-2
2.011E-1
 5 200
41 GSE12198 CTRL VS LOW IL2 STIM NK CELL UP Genes up-regulated in NK cells: primary versus stimulated by low dose of IL2 [GeneID=3558]. MSigDB C7: Immunologic Signatures (v5.1) 4.948E-5 3.591E-3 3.191E-2
2.011E-1
 5 200
42 GSE44649 WT VS MIR155 KO NAIVE CD8 TCELL UP Genes up-regulated in resting CD8 T cells: wildtype versus MIR155 [GeneID=406947] knockout. MSigDB C7: Immunologic Signatures (v5.1) 4.948E-5 3.591E-3 3.191E-2
2.011E-1
 5 200
43 M6837 Genes down-regulated in CD4 [GeneID=920] T cells from lymph nodes: naïve versus day 7 after immunization. MSigDB C7: Immunologic Signatures (v5.1) 4.948E-5 3.591E-3 3.191E-2
2.011E-1
 5 200
44 M3091 Genes down-regulated in comparison of systemic lupus erythematosus B cells versus systemic lupus erythromatosus myeloid cells. MSigDB C7: Immunologic Signatures (v5.1) 4.948E-5 3.591E-3 3.191E-2
2.011E-1
 5 200
45 GSE19401 NAIVE VS IMMUNIZED MOUSE PLN FOLLICULAR DC UP Genes up-regulated in ex vivo follicular dendritic cells from peripheral lymph nodes: naïve versus immunized mice. MSigDB C7: Immunologic Signatures (v5.1) 4.948E-5 3.591E-3 3.191E-2
2.011E-1
 5 200
46 M5463 Genes up-regulated in comparison of dendritic cells (DC) versus B cells. MSigDB C7: Immunologic Signatures (v5.1) 4.948E-5 3.591E-3 3.191E-2
2.011E-1
 5 200
47 M4486 Genes down-regulated in comparison of naive B cells versus day 0 monocytes. MSigDB C7: Immunologic Signatures (v5.1) 4.948E-5 3.591E-3 3.191E-2
2.011E-1
 5 200
48 GSE36078 WT VS IL1R KO LUNG DC DN Genes down-regulated in Lung dendritic cell from untreated wildtype mice versus Lung dendritic cell from untreated IL-1R mice. MSigDB C7: Immunologic Signatures (v5.1) 4.948E-5 3.591E-3 3.191E-2
2.011E-1
 5 200
49 M4316 Genes up-regulated in comparison of TregLP versus DEC-Pept Convert (see Table 1S in the paper for details). MSigDB C7: Immunologic Signatures (v5.1) 4.948E-5 3.591E-3 3.191E-2
2.011E-1
 5 200
50 M4962 Genes down-regulated in comparison of B cells from influenza vaccinee at day 7 post-vaccination versus myeloid dendritic cells (mDC) at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v5.1) 4.948E-5 3.591E-3 3.191E-2
2.011E-1
 5 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 1573 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 1.706E-15 2.684E-12 2.131E-11 2.684E-12 16 496
2 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 1.527E-11 8.633E-9 6.853E-8 2.401E-8 13 493
3 astrocytes Top 500 All astrocytes Top 500 All Brain Map - Barres 1.646E-11 8.633E-9 6.853E-8 2.590E-8 13 496
4 astrocytes Top 500 Cluster 0 astrocytes Top 500 Cluster 0 Brain Map - Barres 3.408E-11 1.184E-8 9.400E-8 5.362E-8 7 59
5 Lungmap Mouse e18.5 Epithelial (GSE52583) SubClass Clara Top 500 All Mouse Lung E18.5 Epithelial Clara top 500 Lungmap Mouse Single Cell (Lungmap.net) 3.764E-11 1.184E-8 9.400E-8 5.921E-8 12 416
6 54Dn Top 500 Cluster 3 54Dn Top 500 Cluster 3 Brain Map - Allen iN 5.259E-10 1.379E-7 1.094E-6 8.272E-7 6 46
7 54Dn SubClass 54Dn 1SK Top 500 Cluster 0 54Dn SubClass 54Dn 1SK Top 500 Cluster 0 Brain Map - Allen iN 3.367E-9 7.201E-7 5.717E-6 5.296E-6 6 62
8 OPC Top 500 All OPC Top 500 All Brain Map - Barres 4.210E-9 7.201E-7 5.717E-6 6.623E-6 11 494
9 endothelial Top 500 Cluster 1 endothelial Top 500 Cluster 1 Brain Map - Barres 4.404E-9 7.201E-7 5.717E-6 6.927E-6 5 30
10 26Dn SubClass 26Dn 2 Top 500 All 26Dn SubClass 26Dn 2 Top 500 All Brain Map - Allen iN 4.578E-9 7.201E-7 5.717E-6 7.201E-6 11 498
11 microglia Top 500 Cluster 0 microglia Top 500 Cluster 0 Brain Map - Barres 1.660E-8 2.374E-6 1.885E-5 2.611E-5 4 14
12 OPC Top 500 Cluster 4 OPC Top 500 Cluster 4 Brain Map - Barres 5.721E-8 7.023E-6 5.575E-5 9.000E-5 5 49
13 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 5.805E-8 7.023E-6 5.575E-5 9.131E-5 10 494
14 gudmap kidney adult RenCorpuscGlomer k3 1000 kidney adult RenCorpuscGlomer k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.389E-7 1.518E-5 1.205E-4 2.185E-4 7 192
15 GSM854306 500 Myeloid Cells, GN.Bl, CD11b+ Ly6-G+, Blood, avg-3 Immgen.org, GSE15907 1.447E-7 1.518E-5 1.205E-4 2.277E-4 9 409
16 fetal replicating Top 500 Cluster 2 fetal replicating Top 500 Cluster 2 Brain Map - Barres 2.063E-7 2.028E-5 1.610E-4 3.245E-4 4 25
17 endothelial Top 500 Cluster 2 endothelial Top 500 Cluster 2 Brain Map - Barres 3.037E-7 2.810E-5 2.231E-4 4.777E-4 5 68
18 GSM538280 500 Myeloid Cells, DC.LC.Sk, MHCII+ CD11b+ CD45+, Skin, avg-2 Immgen.org, GSE15907 3.362E-7 2.938E-5 2.332E-4 5.288E-4 9 452
19 GSM777037 500 Stromal Cells, BEC.SLN, gp38- CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 3.824E-7 3.120E-5 2.476E-4 6.016E-4 9 459
20 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 3.966E-7 3.120E-5 2.476E-4 6.239E-4 9 461
21 microglia Top 500 All microglia Top 500 All Brain Map - Barres 6.715E-7 5.030E-5 3.993E-4 1.056E-3 9 491
22 endothelial SubClass MFSD2-hi Top 500 Cluster 0 endothelial SubClass MFSD2-hi Top 500 Cluster 0 Brain Map - Barres 1.180E-6 8.438E-5 6.699E-4 1.856E-3 4 38
23 GSM854312 500 Myeloid Cells, GN.UrAc.PC, CD11b+ Ly6-G+, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 1.906E-6 1.282E-4 1.018E-3 2.999E-3 8 410
24 gudmap kidney e15.5 SmlBldVes Tie2 500 kidney e15.5 SmlBldVes Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.013E-6 1.282E-4 1.018E-3 3.166E-3 8 413
25 gudmap kidney e15.5 SmlBldVes Tie2 k2 1000 kidney e15.5 SmlBldVes Tie2 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.087E-6 1.282E-4 1.018E-3 3.283E-3 5 100
26 GSM854309 500 Myeloid Cells, GN.Thio.PC, CD11b+ Ly6-G+, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 2.124E-6 1.282E-4 1.018E-3 3.341E-3 8 416
27 GSM854338 500 Myeloid Cells, GN.Arth.SynF, CD11b+ Ly6-G+, Synovial Fluid, avg-3 Immgen.org, GSE15907 2.201E-6 1.282E-4 1.018E-3 3.462E-3 8 418
28 54Dn SubClass 54Dn 5 Top 500 Cluster 3 54Dn SubClass 54Dn 5 Top 500 Cluster 3 Brain Map - Allen iN 2.813E-6 1.580E-4 1.254E-3 4.425E-3 4 47
29 gudmap kidney e15.5 SmlBldVes Tie2 k2 500 kidney e15.5 SmlBldVes Tie2 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.237E-6 2.298E-4 1.824E-3 6.665E-3 4 52
30 54SK Top 500 All 54SK Top 500 All Brain Map - Allen iN 6.884E-6 3.546E-4 2.815E-3 1.083E-2 8 488
31 endothelial SubClass endothelial all Top 500 All endothelial SubClass endothelial all Top 500 All Brain Map - Barres 6.987E-6 3.546E-4 2.815E-3 1.099E-2 8 489
32 26Dn Top 500 All 26Dn Top 500 All Brain Map - Allen iN 7.751E-6 3.810E-4 3.025E-3 1.219E-2 8 496
33 microglia Top 500 Cluster 1 microglia Top 500 Cluster 1 Brain Map - Barres 9.578E-6 4.565E-4 3.624E-3 1.507E-2 3 20
34 GSM605814 500 NK cells, NK.49H+.Sp, NK1.1+ Ly49H+, Spleen, avg-3 Immgen.org, GSE15907 1.905E-5 8.621E-4 6.844E-3 2.996E-2 7 403
35 gudmap kidney adult RenMedVasc Tie2 k4 500 kidney adult RenMedVasc Tie2 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.918E-5 8.621E-4 6.844E-3 3.017E-2 3 25
36 GSM538315 500 NK cells, NK.Sp, NK1.1+, Spleen, avg-3 Immgen.org, GSE15907 2.094E-5 8.959E-4 7.112E-3 3.294E-2 7 409
37 GSM605872 500 Myeloid Cells, Mo.6C+II-.Bl, Cd115+ B220- CD43+ Ly6C+ MHCII-, Blood, avg-3 Immgen.org, GSE15907 2.161E-5 8.959E-4 7.112E-3 3.399E-2 7 411
38 GSM538312 500 NK cells, NK.MCMV7.Sp, CD3-,NK1.1+, Spleen, avg-3 Immgen.org, GSE15907 2.195E-5 8.959E-4 7.112E-3 3.453E-2 7 412
39 GSM854271 500 Myeloid Cells, DC.103-11b+24-.Lu, MHCII+ CD11c+ CD103- CD11b+ CD24-, Lung, avg-2 Immgen.org, GSE15907 2.264E-5 8.959E-4 7.112E-3 3.561E-2 7 414
40 GSM605846 500 Myeloid Cells, GN.BM, CD11b+ Ly6-G+, Bone marrow, avg-4 Immgen.org, GSE15907 2.299E-5 8.959E-4 7.112E-3 3.617E-2 7 415
41 gudmap dev gonad e13.5 F gudmap devVascOvary Flk 500 dev gonad e13.5 F DevVascOvary Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.335E-5 8.959E-4 7.112E-3 3.673E-2 7 416
42 gudmap dev gonad e13.5 M gudmap devVasTestis Flk k4 500 dev gonad e13.5 M DevVasTestis Flk k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.574E-5 9.641E-4 7.654E-3 4.049E-2 6 282
43 GSM538282 500 Myeloid Cells, MF.Lu, CD11chi CD11b- CD103- MHCII- SiglecF+, Lung, avg-3 Immgen.org, GSE15907 2.678E-5 9.795E-4 7.776E-3 4.212E-2 7 425
44 endothelial SubClass endothelial all Top 500 Cluster 3 endothelial SubClass endothelial all Top 500 Cluster 3 Brain Map - Barres 3.156E-5 1.112E-3 8.826E-3 4.964E-2 4 86
45 GSM605865 500 Myeloid Cells, MF.Thio5.II-480int.PC, CD115+ MHCII- F480int SiglecF- CD11c+, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 3.198E-5 1.112E-3 8.826E-3
5.031E-2
 7 437
46 PCBC ratio ECTO blastocyst vs ECTO UCB CD34+Z cfr-2X-p05 ECTO blastocyst vs ECTO UCB CD34+Z-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 3.252E-5 1.112E-3 8.826E-3
5.115E-2
 6 294
47 gudmap dev gonad e12.5 M gudmap devVasTestis Flk k2 500 dev gonad e12.5 M DevVasTestis Flk k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.507E-5 1.160E-3 9.205E-3
5.516E-2
 6 298
48 gudmap dev gonad e11.5 F ReproVasc Flk k3 1000 dev gonad e11.5 F ReproVasc Flk k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.538E-5 1.160E-3 9.205E-3
5.566E-2
 7 444
49 GSM777063 500 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 3.853E-5 1.237E-3 9.820E-3
6.061E-2
 7 450
50 GSM777032 500 Stromal Cells, BEC.MLN, gp38- CD31+, Lymph Node, avg-5 Immgen.org, GSE15907 4.191E-5 1.318E-3 1.047E-2
6.592E-2
 7 456
Show 45 more annotations

15: Computational [Display Chart] 191 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 3 Genes in module 3 MSigDb: C4 - CM: Cancer Modules 1.026E-8 1.959E-6 1.142E-5 1.959E-6 12 375
2 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 6.022E-8 5.751E-6 3.354E-5 1.150E-5 11 351
3 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 1.294E-6 8.237E-5 4.804E-4 2.471E-4 10 378
4 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 3.575E-6 1.707E-4 9.956E-4 6.828E-4 10 423
5 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 7.887E-6 3.013E-4 1.757E-3 1.506E-3 9 361
6 module 6 Genes in module 6 MSigDb: C4 - CM: Cancer Modules 2.068E-5 6.584E-4 3.840E-3 3.950E-3 9 407
7 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 2.606E-5 7.110E-4 4.146E-3 4.977E-3 9 419
8 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 7.571E-4 1.808E-2
1.054E-1
1.446E-1
 7 395
9 module 8 Genes in module 8 MSigDb: C4 - CM: Cancer Modules 8.906E-4 1.890E-2
1.102E-1
1.701E-1
 7 406
10 module 18 Genes in module 18 MSigDb: C4 - CM: Cancer Modules 1.352E-3 2.419E-2
1.411E-1
2.582E-1
 7 436
11 module 44 Genes in module 44 MSigDb: C4 - CM: Cancer Modules 1.393E-3 2.419E-2
1.411E-1
2.661E-1
 6 319
12 module 164 Genes in module 164 MSigDb: C4 - CM: Cancer Modules 1.727E-3 2.749E-2
1.603E-1
3.299E-1
 3 61
Show 7 more annotations

16: MicroRNA [Display Chart] 712 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1244:PITA hsa-miR-1244:PITA TOP PITA 2.024E-5 1.441E-2
1.030E-1
 1.441E-2 6 262
2 hsa-miR-615-3p:mirSVR lowEffct hsa-miR-615-3p:mirSVR conserved lowEffect-0.1-0.5 MicroRNA.org 5.283E-5 1.881E-2
1.344E-1
 3.762E-2 6 311

17: Drug [Display Chart] 9405 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 D001663 Bilirubin CTD 3.459E-8 2.080E-4 2.023E-3 3.253E-4 7 165
2 C512195 elesclomol CTD 4.422E-8 2.080E-4 2.023E-3 4.159E-4 5 49
3 5212 UP prochlorperazine dimaleate salt; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 9.474E-7 1.167E-3 1.135E-2 8.911E-3 6 167
4 1231 UP 15d-PGJ2; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 1.245E-6 1.167E-3 1.135E-2 1.171E-2 6 175
5 1166 UP 17-AAG; Up 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP 1.245E-6 1.167E-3 1.135E-2 1.171E-2 6 175
6 D016685 Mitomycin CTD 1.249E-6 1.167E-3 1.135E-2 1.175E-2 8 408
7 1555 UP Clonidine hydrochloride [4205-91-8]; Up 200; 15uM; HL60; HG-U133A Broad Institute CMAP 1.330E-6 1.167E-3 1.135E-2 1.251E-2 6 177
8 7555 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 1.330E-6 1.167E-3 1.135E-2 1.251E-2 6 177
9 2685 UP 17-AAG; Up 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP 1.375E-6 1.167E-3 1.135E-2 1.293E-2 6 178
10 6210 UP Disulfiram [97-77-8]; Up 200; 13.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.420E-6 1.167E-3 1.135E-2 1.336E-2 6 179
11 1819 UP Triamterene [396-01-0]; Up 200; 15.8uM; PC3; HT HG-U133A Broad Institute CMAP 1.420E-6 1.167E-3 1.135E-2 1.336E-2 6 179
12 1613 UP Clenbuterol hydrochloride [21898-19-1]; Up 200; 12.8uM; HL60; HG-U133A Broad Institute CMAP 1.515E-6 1.167E-3 1.135E-2 1.425E-2 6 181
13 C037123 cadmium sulfate CTD 1.613E-6 1.167E-3 1.135E-2 1.517E-2 7 291
14 5327 UP Benfluorex hydrochloride [23642-66-2]; Up 200; 10.4uM; MCF7; HT HG-U133A Broad Institute CMAP 2.070E-6 1.293E-3 1.257E-2 1.947E-2 6 191
15 C026137 3-hydroxyacetanilide CTD 2.161E-6 1.293E-3 1.257E-2 2.032E-2 5 106
16 971 UP oxaprozin; Up 200; 300uM; MCF7; HT HG-U133A EA Broad Institute CMAP 2.199E-6 1.293E-3 1.257E-2 2.068E-2 6 193
17 C472349 oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine CTD 8.458E-6 4.679E-3 4.551E-2
7.955E-2
 5 140
18 D010081 Oxazolone CTD 1.041E-5 5.437E-3
5.288E-2
9.787E-2
 6 253
19 C079836 tyrphostin 25 CTD 1.161E-5 5.595E-3
5.442E-2
1.092E-1
 2 3
20 D016566 Organoselenium Compounds CTD 1.205E-5 5.595E-3
5.442E-2
1.133E-1
 4 71
21 1520 UP Azacyclonol [115-46-8]; Up 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 1.343E-5 5.595E-3
5.442E-2
1.263E-1
 5 154
22 2210 UP Mefloquine hydrochloride [51773-92-3]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP 1.616E-5 5.595E-3
5.442E-2
1.520E-1
 5 160
23 7068 UP MG-262; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.665E-5 5.595E-3
5.442E-2
1.566E-1
 5 161
24 7079 UP MG-262; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.820E-5 5.595E-3
5.442E-2
1.712E-1
 5 164
25 956 UP 5224221; Up 200; 12uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.930E-5 5.595E-3
5.442E-2
1.815E-1
 5 166
26 1234 UP Trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 1.986E-5 5.595E-3
5.442E-2
1.868E-1
 5 167
27 2691 UP 15d-PGJ2; Up 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP 2.104E-5 5.595E-3
5.442E-2
1.978E-1
 5 169
28 1736 UP Parthenolide [20554-84-1]; Up 200; 16.2uM; HL60; HG-U133A Broad Institute CMAP 2.104E-5 5.595E-3
5.442E-2
1.978E-1
 5 169
29 CID013736776 difluoromethylphosphonic acid Stitch 2.319E-5 5.595E-3
5.442E-2
2.181E-1
 2 4
30 1672 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 2.354E-5 5.595E-3
5.442E-2
2.214E-1
 5 173
31 6451 UP Phenoxybenzamine hydrochloride [63-92-3]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP 2.354E-5 5.595E-3
5.442E-2
2.214E-1
 5 173
32 869 UP wortmannin; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP 2.488E-5 5.595E-3
5.442E-2
2.340E-1
 5 175
33 3746 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 2.488E-5 5.595E-3
5.442E-2
2.340E-1
 5 175
34 1057 UP radicicol, diheterospora chlamydosporia; Up 200; 0.1uM; MCF7; HT HG-U133A EA Broad Institute CMAP 2.488E-5 5.595E-3
5.442E-2
2.340E-1
 5 175
35 5291 UP Chlorprothixene hydrochloride [6469-93-8]; Up 200; 11.4uM; MCF7; HT HG-U133A Broad Institute CMAP 2.557E-5 5.595E-3
5.442E-2
2.404E-1
 5 176
36 7047 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 2.557E-5 5.595E-3
5.442E-2
2.404E-1
 5 176
37 1393 UP Nocodazole [31430-18-9]; Up 200; 13.2uM; HL60; HG-U133A Broad Institute CMAP 2.557E-5 5.595E-3
5.442E-2
2.404E-1
 5 176
38 1172 UP 15d-PGJ2; Up 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP 2.557E-5 5.595E-3
5.442E-2
2.404E-1
 5 176
39 6784 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 2.627E-5 5.595E-3
5.442E-2
2.471E-1
 5 177
40 2679 UP radicicol, diheterospora chlamydosporia; Up 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP 2.699E-5 5.595E-3
5.442E-2
2.538E-1
 5 178
41 916 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP 2.699E-5 5.595E-3
5.442E-2
2.538E-1
 5 178
42 4554 UP Withaferin A [5119-48-2]; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 2.699E-5 5.595E-3
5.442E-2
2.538E-1
 5 178
43 579 DN fisetin; Down 200; 50uM; PC3; HG-U133A Broad Institute CMAP 2.699E-5 5.595E-3
5.442E-2
2.538E-1
 5 178
44 4184 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 2.772E-5 5.595E-3
5.442E-2
2.607E-1
 5 179
45 839 UP 5224221; Up 200; 12uM; MCF7; HT HG-U133A EA Broad Institute CMAP 2.772E-5 5.595E-3
5.442E-2
2.607E-1
 5 179
46 4652 UP Phenoxybenzamine hydrochloride [63-92-3]; Up 200; 11.8uM; PC3; HT HG-U133A Broad Institute CMAP 2.847E-5 5.595E-3
5.442E-2
2.678E-1
 5 180
47 3688 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 2.924E-5 5.595E-3
5.442E-2
2.750E-1
 5 181
48 7453 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 2.924E-5 5.595E-3
5.442E-2
2.750E-1
 5 181
49 998 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP 3.002E-5 5.595E-3
5.442E-2
2.824E-1
 5 182
50 1280 UP Ritodrine hydrochloride [23239-51-2]; Up 200; 12.4uM; HL60; HT HG-U133A Broad Institute CMAP 3.002E-5 5.595E-3
5.442E-2
2.824E-1
 5 182
Show 45 more annotations

18: Disease [Display Chart] 732 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0280785 Diffuse Astrocytoma DisGeNET BeFree 1.209E-4 3.088E-2
2.215E-1
8.852E-2
 3 39
2 umls:C0011859 Lipoatrophic Diabetes Mellitus DisGeNET Curated 3.244E-4 3.088E-2
2.215E-1
2.374E-1
 2 11
3 umls:C0476122 ovarian serous tumor DisGeNET BeFree 3.886E-4 3.088E-2
2.215E-1
2.845E-1
 2 12
4 umls:C0334287 Fibrolamellar hepatocellular carcinoma DisGeNET BeFree 6.154E-4 3.088E-2
2.215E-1
4.505E-1
 2 15
5 umls:C0751396 Well Differentiated Oligodendroglioma DisGeNET BeFree 7.884E-4 3.088E-2
2.215E-1
5.771E-1
 4 169
6 umls:C1511789 Desmoplastic DisGeNET BeFree 8.400E-4 3.088E-2
2.215E-1
6.149E-1
 3 75
7 umls:C0028945 oligodendroglioma DisGeNET Curated 8.789E-4 3.088E-2
2.215E-1
6.434E-1
 4 174
8 umls:C0476073 Papillary neoplasm DisGeNET BeFree 9.959E-4 3.088E-2
2.215E-1
7.290E-1
 2 19
9 umls:C0023787 Lipodystrophy DisGeNET Curated 1.208E-3 3.088E-2
2.215E-1
8.841E-1
 3 85
10 umls:C0025312 Meningomyelocele DisGeNET Curated 1.339E-3 3.088E-2
2.215E-1
9.802E-1
 2 22
11 umls:C0221032 Familial generalized lipodystrophy DisGeNET Curated 1.595E-3 3.088E-2
2.215E-1
1.000E0
 2 24
12 612526 LIPODYSTROPHY, CONGENITAL GENERALIZED, TYPE 3; CGL3 OMIM 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
13 umls:C0342278 Diabetes Mellitus, Insulin-Resistant, with Acanthosis Nigricans DisGeNET Curated 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
14 umls:C3809192 PULMONARY HYPERTENSION, PRIMARY, 3 DisGeNET Curated 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
15 613453 DEAFNESS, AUTOSOMAL RECESSIVE 91; DFNB91 OMIM 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
16 umls:C2751321 Macrocephaly, Alopecia, Cutis Laxa, and Scoliosis DisGeNET Curated 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
17 607821 DEAFNESS, AUTOSOMAL RECESSIVE 37; DFNB37 OMIM 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
18 cv:C1853441 Deafness, autosomal dominant 22 Clinical Variations 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
19 umls:C3150704 DEAFNESS, AUTOSOMAL RECESSIVE 91 DisGeNET Curated 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
20 umls:C1963745 HAIR-AN syndrome DisGeNET BeFree 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
21 umls:C2363755 Acquired Protein S Deficiency DisGeNET BeFree 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
22 612656 EPISODIC ATAXIA, TYPE 6; EA6 OMIM 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
23 umls:C1864663 HYPOMYELINATION AND CONGENITAL CATARACT DisGeNET Curated 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
24 cv:C2674508 Hypomyelination and Congenital Cataract Clinical Variations 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
25 umls:C0271690 Type 2 diabetes mellitus with acanthosis nigricans DisGeNET Curated 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
26 umls:C3501265 Deafness, Sensorineural, with Hypertrophic Cardiomyopathy DisGeNET Curated 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
27 umls:C2931767 Deafness, autosomal dominant nonsyndromic sensorineural 22 DisGeNET Curated 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
28 262190 PINEAL HYPERPLASIA, INSULIN-RESISTANT DIABETES MELLITUS, AND SOMATIC ABNORMALITIES OMIM 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
29 cv:C2675211 Episodic ataxia, type 6 Clinical Variations 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
30 cv:C3150704 Deafness, autosomal recessive 91 Clinical Variations 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
31 cv:C1865639 Gracile bone dysplasia Clinical Variations 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
32 umls:C1865639 Gracile bone dysplasia DisGeNET Curated 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
33 cv:C1835662 Keratosis palmoplantaris papulosa Clinical Variations 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
34 610549 DIABETES MELLITUS, INSULIN-RESISTANT, WITH ACANTHOSIS NIGRICANS OMIM 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
35 umls:C1864952 Hyperinsulinemic Hypoglycemia, Familial, 5 DisGeNET Curated 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
36 cv:C0021400 Influenza Clinical Variations 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
37 umls:C1843028 Deafness, Autosomal Recessive 37 DisGeNET Curated 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
38 cv:C0265344 Leprechaunism syndrome Clinical Variations 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
39 cv:CN031291 Kenny-Caffey syndrome type 2 Clinical Variations 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
40 cv:C0271695 Pineal hyperplasia AND diabetes mellitus syndrome Clinical Variations 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
41 umls:C1835662 Keratosis palmoplantaris papulosa DisGeNET Curated 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
42 cv:CN178222 Primary pulmonary hypertension 3 Clinical Variations 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
43 umls:C2239290 Hodgkin lymphoma, nodular lymphocyte predominance DisGeNET BeFree 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
44 cv:C1864952 Hyperinsulinemic hypoglycemia familial 5 Clinical Variations 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
45 cv:C0271690 Insulin-resistant diabetes mellitus AND acanthosis nigricans Clinical Variations 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
46 cv:C1843028 Deafness, autosomal recessive 37 Clinical Variations 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
47 cv:C1847582 Lipodystrophy with congenital cataracts and neurodegeneration Clinical Variations 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
48 cv:C2675861 Lipodystrophy, congenital generalized, type 3 Clinical Variations 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
49 umls:C1847582 Lipodystrophy with Congenital Cataracts and Neurodegeneration DisGeNET Curated 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
50 610532 LEUKODYSTROPHY, HYPOMYELINATING, 5 OMIM 2.477E-3 3.088E-2
2.215E-1
1.000E0
 1 1
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