Toppgene analysis for aggregated_1964_log, IC22, positive side

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1: GO: Molecular Function [Display Chart] 739 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0023026 MHC class II protein complex binding 2.515E-5 6.678E-3 4.797E-2 1.859E-2 4 16
2 GO:0042605 peptide antigen binding 2.659E-5 6.678E-3 4.797E-2 1.965E-2 5 32
3 GO:0008131 primary amine oxidase activity 2.711E-5 6.678E-3 4.797E-2 2.003E-2 3 6
4 GO:0005539 glycosaminoglycan binding 3.830E-5 7.077E-3
5.083E-2
2.831E-2 11 219
5 GO:0023023 MHC protein complex binding 5.217E-5 7.710E-3
5.538E-2
3.855E-2 4 19
6 GO:0042277 peptide binding 7.444E-5 9.168E-3
6.586E-2
5.501E-2
12 278
7 GO:0008201 heparin binding 1.146E-4 1.209E-2
8.687E-2
8.466E-2
9 167
8 GO:0033218 amide binding 2.005E-4 1.852E-2
1.330E-1
1.482E-1
12 309
9 GO:0032395 MHC class II receptor activity 2.837E-4 2.330E-2
1.673E-1
2.097E-1
3 12
10 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity 3.726E-4 2.578E-2
1.852E-1
2.753E-1
2 3
11 GO:0003823 antigen binding 4.113E-4 2.578E-2
1.852E-1
3.040E-1
7 120
12 GO:0008236 serine-type peptidase activity 4.186E-4 2.578E-2
1.852E-1
3.094E-1
10 242
13 GO:0017171 serine hydrolase activity 4.611E-4 2.621E-2
1.883E-1
3.407E-1
10 245
14 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 5.724E-4 2.970E-2
2.134E-1
4.230E-1
3 15
15 GO:0050839 cell adhesion molecule binding 6.029E-4 2.970E-2
2.134E-1
4.456E-1
9 209
16 GO:1901681 sulfur compound binding 7.307E-4 3.375E-2
2.424E-1
5.400E-1
10 260
17 GO:0019955 cytokine binding 1.072E-3 4.662E-2
3.349E-1
7.926E-1
6 103
18 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1.179E-3 4.842E-2
3.478E-1
8.715E-1
3 19
Show 13 more annotations

2: GO: Biological Process [Display Chart] 3854 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0060333 interferon-gamma-mediated signaling pathway 3.150E-9 1.087E-5 9.598E-5 1.214E-5 11 85
2 GO:0031589 cell-substrate adhesion 5.638E-9 1.087E-5 9.598E-5 2.173E-5 19 324
3 GO:0071346 cellular response to interferon-gamma 6.765E-8 8.298E-5 7.330E-4 2.607E-4 12 140
4 GO:0007160 cell-matrix adhesion 1.011E-7 8.298E-5 7.330E-4 3.896E-4 14 206
5 GO:0019724 B cell mediated immunity 1.076E-7 8.298E-5 7.330E-4 4.149E-4 12 146
6 GO:0002526 acute inflammatory response 2.738E-7 1.759E-4 1.554E-3 1.055E-3 12 159
7 GO:0034341 response to interferon-gamma 3.584E-7 1.973E-4 1.743E-3 1.381E-3 12 163
8 GO:0016064 immunoglobulin mediated immune response 7.186E-7 3.121E-4 2.757E-3 2.769E-3 11 143
9 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 7.288E-7 3.121E-4 2.757E-3 2.809E-3 15 279
10 GO:0048511 rhythmic process 1.088E-6 4.191E-4 3.703E-3 4.191E-3 17 368
11 GO:0001525 angiogenesis 1.568E-6 5.492E-4 4.852E-3 6.041E-3 19 465
12 GO:0045785 positive regulation of cell adhesion 1.926E-6 6.185E-4 5.464E-3 7.422E-3 18 427
13 GO:0034405 response to fluid shear stress 3.434E-6 9.222E-4 8.147E-3 1.323E-2 6 37
14 GO:0002455 humoral immune response mediated by circulating immunoglobulin 3.448E-6 9.222E-4 8.147E-3 1.329E-2 8 80
15 GO:0002576 platelet degranulation 3.589E-6 9.222E-4 8.147E-3 1.383E-2 9 107
16 GO:0071621 granulocyte chemotaxis 4.514E-6 1.087E-3 9.606E-3 1.740E-2 9 110
17 GO:0010038 response to metal ion 4.942E-6 1.120E-3 9.897E-3 1.905E-2 16 368
18 GO:0050923 regulation of negative chemotaxis 5.702E-6 1.221E-3 1.079E-2 2.198E-2 3 4
19 GO:0060326 cell chemotaxis 7.255E-6 1.472E-3 1.300E-2 2.796E-2 13 255
20 GO:0007409 axonogenesis 9.186E-6 1.770E-3 1.564E-2 3.540E-2 18 478
21 GO:0097530 granulocyte migration 1.127E-5 2.068E-3 1.827E-2 4.343E-2 9 123
22 GO:0030198 extracellular matrix organization 1.335E-5 2.161E-3 1.909E-2
5.143E-2
15 354
23 GO:0043062 extracellular structure organization 1.380E-5 2.161E-3 1.909E-2
5.317E-2
15 355
24 GO:0002503 peptide antigen assembly with MHC class II protein complex 1.414E-5 2.161E-3 1.909E-2
5.448E-2
3 5
25 GO:0002399 MHC class II protein complex assembly 1.414E-5 2.161E-3 1.909E-2
5.448E-2
3 5
26 GO:0038166 angiotensin-activated signaling pathway 1.472E-5 2.161E-3 1.909E-2
5.671E-2
4 14
27 GO:0002449 lymphocyte mediated immunity 1.564E-5 2.161E-3 1.909E-2
6.026E-2
13 274
28 GO:0070228 regulation of lymphocyte apoptotic process 1.570E-5 2.161E-3 1.909E-2
6.051E-2
7 71
29 GO:0002250 adaptive immune response 1.683E-5 2.237E-3 1.976E-2
6.487E-2
16 406
30 GO:0030595 leukocyte chemotaxis 1.839E-5 2.301E-3 2.033E-2
7.088E-2
11 200
31 GO:0045765 regulation of angiogenesis 1.908E-5 2.301E-3 2.033E-2
7.353E-2
12 239
32 GO:1901565 organonitrogen compound catabolic process 1.911E-5 2.301E-3 2.033E-2
7.364E-2
15 365
33 GO:0060560 developmental growth involved in morphogenesis 2.159E-5 2.521E-3 2.227E-2
8.320E-2
12 242
34 GO:0030278 regulation of ossification 2.531E-5 2.868E-3 2.534E-2
9.753E-2
11 207
35 GO:0002396 MHC protein complex assembly 2.803E-5 2.894E-3 2.557E-2
1.080E-1
3 6
36 GO:0002501 peptide antigen assembly with MHC protein complex 2.803E-5 2.894E-3 2.557E-2
1.080E-1
3 6
37 GO:0051272 positive regulation of cellular component movement 2.812E-5 2.894E-3 2.557E-2
1.084E-1
17 471
38 GO:0002683 negative regulation of immune system process 2.853E-5 2.894E-3 2.557E-2
1.100E-1
16 424
39 GO:0097529 myeloid leukocyte migration 3.046E-5 3.010E-3 2.659E-2
1.174E-1
10 174
40 GO:0040017 positive regulation of locomotion 3.385E-5 3.262E-3 2.881E-2
1.305E-1
17 478
41 GO:0050900 leukocyte migration 3.756E-5 3.531E-3 3.119E-2
1.448E-1
15 387
42 GO:0006953 acute-phase response 4.009E-5 3.679E-3 3.250E-2
1.545E-1
6 56
43 GO:0072376 protein activation cascade 4.149E-5 3.719E-3 3.285E-2
1.599E-1
8 112
44 GO:0048771 tissue remodeling 4.679E-5 4.099E-3 3.621E-2
1.803E-1
10 183
45 GO:0015850 organic hydroxy compound transport 4.870E-5 4.109E-3 3.630E-2
1.877E-1
12 263
46 GO:1901342 regulation of vasculature development 5.052E-5 4.109E-3 3.630E-2
1.947E-1
12 264
47 GO:0001558 regulation of cell growth 5.087E-5 4.109E-3 3.630E-2
1.961E-1
16 445
48 GO:0006959 humoral immune response 5.207E-5 4.109E-3 3.630E-2
2.007E-1
11 224
49 GO:0030335 positive regulation of cell migration 5.224E-5 4.109E-3 3.630E-2
2.013E-1
16 446
50 GO:1904385 cellular response to angiotensin 5.450E-5 4.201E-3 3.711E-2
2.100E-1
4 19
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 324 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0042613 MHC class II protein complex 1.279E-8 2.255E-6 1.434E-5 4.144E-6 6 16
2 GO:0042611 MHC protein complex 1.392E-8 2.255E-6 1.434E-5 4.510E-6 7 27
3 GO:0098576 lumenal side of membrane 6.328E-8 6.834E-6 4.346E-5 2.050E-5 7 33
4 GO:0060205 cytoplasmic vesicle lumen 2.439E-7 1.976E-5 1.257E-4 7.903E-5 10 104
5 GO:0031983 vesicle lumen 3.482E-7 2.256E-5 1.435E-4 1.128E-4 10 108
6 GO:0034774 secretory granule lumen 4.319E-7 2.332E-5 1.483E-4 1.399E-4 9 85
7 GO:0098553 lumenal side of endoplasmic reticulum membrane 6.726E-7 2.724E-5 1.732E-4 2.179E-4 6 29
8 GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane 6.726E-7 2.724E-5 1.732E-4 2.179E-4 6 29
9 GO:0031091 platelet alpha granule 1.813E-6 6.527E-5 4.151E-4 5.874E-4 8 75
10 GO:0031093 platelet alpha granule lumen 2.444E-6 7.918E-5 5.035E-4 7.918E-4 7 55
11 GO:0072562 blood microparticle 4.584E-6 1.350E-4 8.587E-4 1.485E-3 10 143
12 GO:0031012 extracellular matrix 1.021E-5 2.642E-4 1.680E-3 3.308E-3 17 444
13 GO:0009897 external side of plasma membrane 1.060E-5 2.642E-4 1.680E-3 3.434E-3 14 311
14 GO:0012507 ER to Golgi transport vesicle membrane 3.227E-5 7.469E-4 4.750E-3 1.046E-2 6 55
15 GO:0042383 sarcolemma 5.453E-5 1.178E-3 7.490E-3 1.767E-2 9 153
16 GO:0045177 apical part of cell 9.548E-5 1.933E-3 1.230E-2 3.093E-2 15 429
17 GO:0045334 clathrin-coated endocytic vesicle 1.081E-4 2.060E-3 1.310E-2 3.502E-2 6 68
18 GO:0035692 macrophage migration inhibitory factor receptor complex 1.229E-4 2.061E-3 1.311E-2 3.981E-2 2 2
19 GO:0045121 membrane raft 1.272E-4 2.061E-3 1.311E-2 4.123E-2 13 343
20 GO:0098857 membrane microdomain 1.272E-4 2.061E-3 1.311E-2 4.123E-2 13 343
21 GO:0030134 ER to Golgi transport vesicle 1.376E-4 2.123E-3 1.350E-2 4.457E-2 6 71
22 GO:0005771 multivesicular body 1.528E-4 2.251E-3 1.431E-2 4.951E-2 5 46
23 GO:0030141 secretory granule 1.659E-4 2.338E-3 1.487E-2
5.377E-2
14 401
24 GO:0030669 clathrin-coated endocytic vesicle membrane 2.279E-4 3.076E-3 1.956E-2
7.383E-2
5 50
25 GO:0034364 high-density lipoprotein particle 2.460E-4 3.188E-3 2.028E-2
7.970E-2
4 28
26 GO:0005765 lysosomal membrane 2.917E-4 3.500E-3 2.226E-2
9.450E-2
11 278
27 GO:0098852 lytic vacuole membrane 2.917E-4 3.500E-3 2.226E-2
9.450E-2
11 278
28 GO:0005775 vacuolar lumen 3.172E-4 3.670E-3 2.334E-2
1.028E-1
7 116
29 GO:0005578 proteinaceous extracellular matrix 3.359E-4 3.753E-3 2.387E-2
1.088E-1
13 379
30 GO:0005916 fascia adherens 3.562E-4 3.847E-3 2.446E-2
1.154E-1
3 13
31 GO:0016323 basolateral plasma membrane 4.301E-4 4.495E-3 2.858E-2
1.393E-1
10 245
32 GO:0043202 lysosomal lumen 4.453E-4 4.509E-3 2.867E-2
1.443E-1
6 88
33 GO:0014704 intercalated disc 4.966E-4 4.876E-3 3.101E-2
1.609E-1
5 59
34 GO:0005802 trans-Golgi network 7.160E-4 6.823E-3 4.339E-2
2.320E-1
9 216
35 GO:0030139 endocytic vesicle 8.128E-4 7.524E-3 4.785E-2
2.634E-1
10 266
36 GO:0005770 late endosome 9.263E-4 8.337E-3
5.302E-2
3.001E-1
9 224
37 GO:1990777 lipoprotein particle 9.895E-4 8.437E-3
5.365E-2
3.206E-1
4 40
38 GO:0034358 plasma lipoprotein particle 9.895E-4 8.437E-3
5.365E-2
3.206E-1
4 40
39 GO:0032994 protein-lipid complex 1.191E-3 9.895E-3
6.293E-2
3.859E-1
4 42
40 GO:0044291 cell-cell contact zone 1.235E-3 1.001E-2
6.363E-2
4.002E-1
5 72
41 GO:0032432 actin filament bundle 1.397E-3 1.104E-2
7.021E-2
4.526E-1
5 74
42 GO:0005925 focal adhesion 1.543E-3 1.190E-2
7.569E-2
4.999E-1
12 393
43 GO:0005924 cell-substrate adherens junction 1.715E-3 1.292E-2
8.218E-2
5.556E-1
12 398
44 GO:0030666 endocytic vesicle membrane 1.893E-3 1.370E-2
8.711E-2
6.132E-1
7 157
45 GO:0030055 cell-substrate junction 1.903E-3 1.370E-2
8.711E-2
6.164E-1
12 403
46 GO:0030658 transport vesicle membrane 1.962E-3 1.382E-2
8.789E-2
6.357E-1
7 158
47 GO:0043209 myelin sheath 2.058E-3 1.419E-2
9.023E-2
6.668E-1
8 204
48 GO:0032588 trans-Golgi network membrane 2.203E-3 1.487E-2
9.458E-2
7.138E-1
5 82
49 GO:0030136 clathrin-coated vesicle 2.260E-3 1.494E-2
9.503E-2
7.322E-1
7 162
50 GO:0030665 clathrin-coated vesicle membrane 2.324E-3 1.506E-2
9.576E-2
7.529E-1
5 83
Show 45 more annotations

4: Human Phenotype [Display Chart] 670 annotations before applied cutoff / 4410 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 3271 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000249 abnormal blood vessel physiology 4.077E-6 1.334E-2
1.156E-1
1.334E-2 21 410
2 MP:0005341 decreased susceptibility to atherosclerosis 1.122E-5 1.835E-2
1.591E-1
3.670E-2 7 47
3 MP:0011503 distended jejunum 1.795E-5 1.931E-2
1.674E-1
5.872E-2
3 4
4 MP:0005023 abnormal wound healing 2.946E-5 1.931E-2
1.674E-1
9.638E-2
13 201
5 MP:0005340 altered susceptibility to atherosclerosis 2.952E-5 1.931E-2
1.674E-1
9.656E-2
8 74
6 MP:0000849 abnormal cerebellum morphology 5.175E-5 2.821E-2
2.446E-1
1.693E-1
20 448
7 MP:0002451 abnormal macrophage physiology 7.219E-5 3.202E-2
2.776E-1
2.361E-1
19 422
8 MP:0000801 abnormal temporal lobe morphology 7.832E-5 3.202E-2
2.776E-1
2.562E-1
17 353
9 MP:0005463 abnormal CD4-positive, alpha-beta T cell physiology 1.227E-4 3.301E-2
2.862E-1
4.013E-1
11 170
10 MP:0002908 delayed wound healing 1.291E-4 3.301E-2
2.862E-1
4.222E-1
7 68
11 MP:0002961 abnormal axon guidance 1.291E-4 3.301E-2
2.862E-1
4.222E-1
7 68
12 MP:0000847 abnormal metencephalon morphology 1.416E-4 3.301E-2
2.862E-1
4.633E-1
20 482
13 MP:0005167 abnormal blood-brain barrier function 1.444E-4 3.301E-2
2.862E-1
4.723E-1
5 31
14 MP:0001847 brain inflammation 1.444E-4 3.301E-2
2.862E-1
4.723E-1
5 31
15 MP:0003622 ischuria 1.514E-4 3.301E-2
2.862E-1
4.951E-1
3 7
16 MP:0000807 abnormal hippocampus morphology 2.118E-4 4.329E-2
3.754E-1
6.927E-1
16 347
17 MP:0005027 increased susceptibility to parasitic infection 2.530E-4 4.598E-2
3.987E-1
8.274E-1
8 100
18 MP:0005043 defective assembly of class II molecules 2.761E-4 4.598E-2
3.987E-1
9.030E-1
2 2
19 MP:0005166 decreased susceptibility to injury 2.848E-4 4.598E-2
3.987E-1
9.315E-1
10 157
20 MP:0004166 abnormal limbic system morphology 3.023E-4 4.598E-2
3.987E-1
9.887E-1
17 395
21 MP:0005338 atherosclerotic lesions 3.310E-4 4.598E-2
3.987E-1
1.000E0
8 104
22 MP:0001798 impaired macrophage phagocytosis 3.503E-4 4.598E-2
3.987E-1
1.000E0
6 57
23 MP:0002406 increased susceptibility to infection 3.503E-4 4.598E-2
3.987E-1
1.000E0
18 438
24 MP:0009485 distended ileum 3.545E-4 4.598E-2
3.987E-1
1.000E0
3 9
25 MP:0011333 abnormal kidney inner medulla morphology 3.545E-4 4.598E-2
3.987E-1
1.000E0
3 9
26 MP:0002412 increased susceptibility to bacterial infection 3.655E-4 4.598E-2
3.987E-1
1.000E0
13 258
Show 21 more annotations

6: Domain [Display Chart] 1291 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00179 EGF CA SMART 1.330E-6 9.964E-4 7.713E-3 1.717E-3 10 122
2 IPR001881 EGF-like Ca-bd dom InterPro 1.544E-6 9.964E-4 7.713E-3 1.993E-3 10 124
3 IPR003006 Ig/MHC CS InterPro 4.091E-6 1.060E-3 8.206E-3 5.281E-3 7 58
4 SM00274 FOLN SMART 5.035E-6 1.060E-3 8.206E-3 6.501E-3 4 11
5 IPR003645 Fol N InterPro 5.035E-6 1.060E-3 8.206E-3 6.501E-3 4 11
6 PS00290 IG MHC PROSITE 5.154E-6 1.060E-3 8.206E-3 6.654E-3 7 60
7 IPR026052 DNA-bd prot-inh InterPro 5.748E-6 1.060E-3 8.206E-3 7.420E-3 3 4
8 IPR018097 EGF Ca-bd CS InterPro 1.486E-5 1.920E-3 1.486E-2 1.918E-2 8 97
9 IPR014745 MHC II a/b N InterPro 1.487E-5 1.920E-3 1.486E-2 1.920E-2 4 14
10 3.10.320.10 - Gene3D 1.487E-5 1.920E-3 1.486E-2 1.920E-2 4 14
11 PS01187 EGF CA PROSITE 1.727E-5 2.026E-3 1.569E-2 2.229E-2 8 99
12 PF00993 MHC II alpha Pfam 2.826E-5 3.040E-3 2.353E-2 3.648E-2 3 6
13 PS00022 EGF 1 PROSITE 3.846E-5 3.594E-3 2.782E-2 4.965E-2 12 256
14 SM00407 IGc1 SMART 4.068E-5 3.594E-3 2.782E-2
5.252E-2
6 56
15 IPR013032 EGF-like CS InterPro 4.814E-5 3.594E-3 2.782E-2
6.215E-2
12 262
16 IPR001003 MHC II a N InterPro 4.904E-5 3.594E-3 2.782E-2
6.331E-2
3 7
17 IPR003597 Ig C1-set InterPro 4.977E-5 3.594E-3 2.782E-2
6.425E-2
6 58
18 PS50835 IG LIKE PROSITE 5.011E-5 3.594E-3 2.782E-2
6.469E-2
17 492
19 PF07645 EGF CA Pfam 5.588E-5 3.797E-3 2.939E-2
7.213E-2
7 86
20 IPR011162 MHC I/II-like Ag-recog InterPro 6.702E-5 4.326E-3 3.349E-2
8.653E-2
5 38
21 PS50026 EGF 3 PROSITE 8.519E-5 5.237E-3 4.054E-2
1.100E-1
11 236
22 PF00041 fn3 Pfam 1.009E-4 5.922E-3 4.584E-2
1.303E-1
9 162
23 IPR000742 EGF-like dom InterPro 1.418E-4 7.518E-3
5.819E-2
1.830E-1
11 250
24 IPR003961 FN3 dom InterPro 1.444E-4 7.518E-3
5.819E-2
1.864E-1
10 209
25 PS00010 ASX HYDROXYL PROSITE 1.456E-4 7.518E-3
5.819E-2
1.879E-1
7 100
26 PF02841 GBP C Pfam 1.639E-4 7.558E-3
5.851E-2
2.116E-1
3 10
27 IPR002937 Amino oxidase InterPro 1.639E-4 7.558E-3
5.851E-2
2.116E-1
3 10
28 PF01593 Amino oxidase Pfam 1.639E-4 7.558E-3
5.851E-2
2.116E-1
3 10
29 IPR000152 EGF-type Asp/Asn hydroxyl site InterPro 2.093E-4 8.487E-3
6.570E-2
2.702E-1
7 106
30 PS51715 G GB1 RHD3 PROSITE 2.235E-4 8.487E-3
6.570E-2
2.886E-1
3 11
31 PF02263 GBP Pfam 2.235E-4 8.487E-3
6.570E-2
2.886E-1
3 11
32 IPR015894 Guanylate-bd N InterPro 2.235E-4 8.487E-3
6.570E-2
2.886E-1
3 11
33 IPR003191 Guanylate-bd C InterPro 2.235E-4 8.487E-3
6.570E-2
2.886E-1
3 11
34 IPR030386 G GB1 RHD3 dom InterPro 2.235E-4 8.487E-3
6.570E-2
2.886E-1
3 11
35 PS01186 EGF 2 PROSITE 2.429E-4 8.959E-3
6.935E-2
3.136E-1
11 266
36 SM00060 FN3 SMART 2.741E-4 9.830E-3
7.609E-2
3.539E-1
9 185
37 PF07654 C1-set Pfam 3.644E-4 1.207E-2
9.339E-2
4.705E-1
5 54
38 PF04847 Calcipressin Pfam 3.831E-4 1.207E-2
9.339E-2
4.945E-1
2 3
39 IPR006931 Calcipressin InterPro 3.831E-4 1.207E-2
9.339E-2
4.945E-1
2 3
40 IPR001613 Flavin amine oxidase InterPro 3.831E-4 1.207E-2
9.339E-2
4.945E-1
2 3
41 SM00181 EGF SMART 3.832E-4 1.207E-2
9.339E-2
4.947E-1
10 236
42 PS50853 FN3 PROSITE 4.678E-4 1.438E-2
1.113E-1
6.039E-1
9 199
43 PF00277 SAA Pfam 7.604E-4 1.785E-2
1.382E-1
9.817E-1
2 4
44 IPR024175 Pept S1A C1r/C1S/mannan-bd InterPro 7.604E-4 1.785E-2
1.382E-1
9.817E-1
2 4
45 IPR003172 ML dom InterPro 7.604E-4 1.785E-2
1.382E-1
9.817E-1
2 4
46 PF06140 Ifi-6-16 Pfam 7.604E-4 1.785E-2
1.382E-1
9.817E-1
2 4
47 PS00663 VINCULIN 1 PROSITE 7.604E-4 1.785E-2
1.382E-1
9.817E-1
2 4
48 SM00197 SAA SMART 7.604E-4 1.785E-2
1.382E-1
9.817E-1
2 4
49 IPR000633 Vinculin CS InterPro 7.604E-4 1.785E-2
1.382E-1
9.817E-1
2 4
50 PF02221 E1 DerP2 DerF2 Pfam 7.604E-4 1.785E-2
1.382E-1
9.817E-1
2 4
Show 45 more annotations

7: Pathway [Display Chart] 1076 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 172846 Staphylococcus aureus infection BioSystems: KEGG 1.140E-7 8.801E-5 6.652E-4 1.226E-4 9 59
2 83124 Graft-versus-host disease BioSystems: KEGG 1.722E-7 8.801E-5 6.652E-4 1.853E-4 8 45
3 83095 Type I diabetes mellitus BioSystems: KEGG 2.454E-7 8.801E-5 6.652E-4 2.640E-4 8 47
4 187106 Interferon gamma signaling BioSystems: REACTOME 5.855E-7 1.575E-4 1.190E-3 6.300E-4 9 71
5 920963 Allograft Rejection BioSystems: WikiPathways 8.119E-7 1.747E-4 1.321E-3 8.736E-4 7 38
6 83123 Allograft rejection BioSystems: KEGG 1.396E-6 2.504E-4 1.893E-3 1.502E-3 7 41
7 M3008 Genes encoding structural ECM glycoproteins MSigDB C2 BIOCARTA (v5.1) 3.591E-6 5.520E-4 4.172E-3 3.864E-3 13 196
8 144181 Leishmaniasis BioSystems: KEGG 1.044E-5 1.247E-3 9.428E-3 1.123E-2 8 76
9 105712 Amine Oxidase reactions BioSystems: REACTOME 1.069E-5 1.247E-3 9.428E-3 1.150E-2 3 4
10 83121 Autoimmune thyroid disease BioSystems: KEGG 1.208E-5 1.247E-3 9.428E-3 1.300E-2 7 56
11 377873 Herpes simplex infection BioSystems: KEGG 1.275E-5 1.247E-3 9.428E-3 1.372E-2 12 188
12 187103 Interferon Signaling BioSystems: REACTOME 3.072E-5 2.576E-3 1.947E-2 3.306E-2 11 173
13 M5884 Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans MSigDB C2 BIOCARTA (v5.1) 3.112E-5 2.576E-3 1.947E-2 3.349E-2 14 275
14 M6910 Cytokines and Inflammatory Response MSigDB C2 BIOCARTA (v5.1) 4.585E-5 3.055E-3 2.309E-2 4.934E-2 5 29
15 200309 Rheumatoid arthritis BioSystems: KEGG 4.612E-5 3.055E-3 2.309E-2 4.963E-2 8 93
16 83073 Complement and coagulation cascades BioSystems: KEGG 4.827E-5 3.055E-3 2.309E-2
5.194E-2
7 69
17 842771 Inflammatory bowel disease (IBD) BioSystems: KEGG 4.827E-5 3.055E-3 2.309E-2
5.194E-2
7 69
18 128760 Intestinal immune network for IgA production BioSystems: KEGG 7.356E-5 3.979E-3 3.007E-2
7.915E-2
6 51
19 198880 Complement and Coagulation Cascades BioSystems: WikiPathways 7.356E-5 3.979E-3 3.007E-2
7.915E-2
6 51
20 153910 Phagosome BioSystems: KEGG 7.395E-5 3.979E-3 3.007E-2
7.957E-2
10 158
21 645290 MHC class II antigen presentation BioSystems: REACTOME 9.569E-5 4.903E-3 3.706E-2
1.030E-1
8 103
22 83120 Asthma BioSystems: KEGG 1.015E-4 4.966E-3 3.754E-2
1.093E-1
5 34
23 83122 Systemic lupus erythematosus BioSystems: KEGG 1.358E-4 6.353E-3 4.802E-2
1.461E-1
9 138
24 83074 Antigen processing and presentation BioSystems: KEGG 1.461E-4 6.552E-3 4.952E-2
1.572E-1
7 82
25 739007 Spinal Cord Injury BioSystems: WikiPathways 1.721E-4 7.314E-3
5.528E-2
1.852E-1
8 112
26 106050 Platelet degranulation BioSystems: REACTOME 1.832E-4 7.314E-3
5.528E-2
1.971E-1
7 85
27 106416 Translocation of ZAP-70 to Immunological synapse BioSystems: REACTOME 1.844E-4 7.314E-3
5.528E-2
1.984E-1
4 21
28 105713 Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2 BioSystems: REACTOME 1.952E-4 7.314E-3
5.528E-2
2.100E-1
2 2
29 83068 ECM-receptor interaction BioSystems: KEGG 1.971E-4 7.314E-3
5.528E-2
2.121E-1
7 86
30 83069 Cell adhesion molecules (CAMs) BioSystems: KEGG 2.191E-4 7.678E-3
5.804E-2
2.358E-1
9 147
31 125138 Viral myocarditis BioSystems: KEGG 2.212E-4 7.678E-3
5.804E-2
2.380E-1
6 62
32 106048 Response to elevated platelet cytosolic Ca2+ BioSystems: REACTOME 2.616E-4 8.705E-3
6.580E-2
2.815E-1
7 90
33 106415 Phosphorylation of CD3 and TCR zeta chains BioSystems: REACTOME 2.670E-4 8.705E-3
6.580E-2
2.873E-1
4 23
34 M18928 IL 5 Signaling Pathway MSigDB C2 BIOCARTA (v5.1) 3.014E-4 9.539E-3
7.210E-2
3.243E-1
3 10
35 576262 Extracellular matrix organization BioSystems: REACTOME 3.344E-4 1.028E-2
7.772E-2
3.599E-1
12 264
36 106418 Downstream TCR signaling BioSystems: REACTOME 4.835E-4 1.445E-2
1.092E-1
5.203E-1
5 47
37 119557 PD-1 signaling BioSystems: REACTOME 5.066E-4 1.473E-2
1.113E-1
5.451E-1
4 27
38 M7298 Antigen Dependent B Cell Activation MSigDB C2 BIOCARTA (v5.1) 5.413E-4 1.533E-2
1.159E-1
5.825E-1
3 12
39 PW:0000527 Angiotensin II signaling through the AT1 receptor Pathway Ontology 5.802E-4 1.542E-2
1.166E-1
6.242E-1
2 3
40 198794 Cytokines and Inflammatory Response BioSystems: WikiPathways 5.846E-4 1.542E-2
1.166E-1
6.290E-1
4 28
41 152665 Malaria BioSystems: KEGG 5.877E-4 1.542E-2
1.166E-1
6.324E-1
5 49
42 212237 Mineral absorption BioSystems: KEGG 7.080E-4 1.814E-2
1.371E-1
7.618E-1
5 51
43 366171 Cytokine Signaling in Immune system BioSystems: REACTOME 7.973E-4 1.995E-2
1.508E-1
8.579E-1
12 291
44 138064 Syndecan-4-mediated signaling events BioSystems: Pathway Interaction Database 8.695E-4 2.014E-2
1.522E-1
9.356E-1
4 31
45 M7146 Classical Complement Pathway MSigDB C2 BIOCARTA (v5.1) 8.774E-4 2.014E-2
1.522E-1
9.441E-1
3 14
46 M12851 Cell to Cell Adhesion Signaling MSigDB C2 BIOCARTA (v5.1) 8.774E-4 2.014E-2
1.522E-1
9.441E-1
3 14
47 83064 TGF-beta signaling pathway BioSystems: KEGG 8.795E-4 2.014E-2
1.522E-1
9.464E-1
6 80
48 217173 Influenza A BioSystems: KEGG 9.240E-4 2.071E-2
1.566E-1
9.942E-1
9 179
49 198916 Oxidative Stress BioSystems: WikiPathways 9.830E-4 2.159E-2
1.632E-1
1.000E0
4 32
50 213780 Tuberculosis BioSystems: KEGG 1.039E-3 2.236E-2
1.690E-1
1.000E0
9 182
Show 45 more annotations

8: Pubmed [Display Chart] 46374 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16502470 Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Pubmed 3.233E-22 1.499E-17 1.698E-16 1.499E-17 19 160
2 16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Pubmed 2.848E-18 6.603E-14 7.475E-13 1.321E-13 19 257
3 20628624 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". Pubmed 2.292E-14 2.658E-10 3.009E-9 1.063E-9 14 172
4 20628624:gr Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". GeneRIF 2.292E-14 2.658E-10 3.009E-9 1.063E-9 14 172
5 14718574 The human plasma proteome: a nonredundant list developed by combination of four separate sources. Pubmed 3.253E-13 3.017E-9 3.416E-8 1.508E-8 13 166
6 20012522 Interactions of viral protein U (Vpu) with cellular factors. Pubmed 1.633E-11 1.262E-7 1.429E-6 7.574E-7 7 27
7 24667918 Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02 AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. Pubmed 2.608E-11 1.728E-7 1.956E-6 1.209E-6 10 105
8 17959659 Human immunodeficiency virus type 1 Vpu protein interacts with CD74 and modulates major histocompatibility complex class II presentation. Pubmed 3.769E-11 2.185E-7 2.473E-6 1.748E-6 6 16
9 12427289 HIV-1 gp120 modulates the immunological function and expression of accessory and co-stimulatory molecules of monocyte-derived dendritic cells. Pubmed 1.799E-10 9.270E-7 1.049E-5 8.343E-6 6 20
10 8084338 HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41. Pubmed 2.510E-10 1.138E-6 1.289E-5 1.164E-5 6 21
11 19948975:gr Integrative predictive model of coronary artery calcification in atherosclerosis. GeneRIF 2.946E-10 1.138E-6 1.289E-5 1.366E-5 12 229
12 19948975 Integrative predictive model of coronary artery calcification in atherosclerosis. Pubmed 2.946E-10 1.138E-6 1.289E-5 1.366E-5 12 229
13 19770068 Role of HIV-1 Nef protein for virus replication in vitro. Pubmed 4.637E-10 1.623E-6 1.838E-5 2.150E-5 6 23
14 22516433 Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Pubmed 4.900E-10 1.623E-6 1.838E-5 2.273E-5 10 141
15 18945465 Human immunodeficiency virus type-1 (HIV-1) Pr55gag virus-like particles are potent activators of human monocytes. Pubmed 6.161E-10 1.905E-6 2.156E-5 2.857E-5 6 24
16 14760718 Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. Pubmed 1.078E-9 3.124E-6 3.537E-5 4.998E-5 7 47
17 7512597 HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4. Pubmed 2.325E-9 5.970E-6 6.759E-5 1.078E-4 5 14
18 1869305 Interaction of CD4 with HLA class II antigens and HIV gp120. Pubmed 2.325E-9 5.970E-6 6.759E-5 1.078E-4 5 14
19 21922073 Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence. Pubmed 3.289E-9 5.970E-6 6.759E-5 1.525E-4 6 31
20 10729169 Efficient incorporation of HLA class II onto human immunodeficiency virus type 1 requires envelope glycoprotein packaging. Pubmed 3.476E-9 5.970E-6 6.759E-5 1.612E-4 5 15
21 22860026 Strategy for identifying dendritic cell-processed CD4+ T cell epitopes from the HIV gag p24 protein. Pubmed 3.476E-9 5.970E-6 6.759E-5 1.612E-4 5 15
22 7602119 Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC. Pubmed 3.476E-9 5.970E-6 6.759E-5 1.612E-4 5 15
23 8376762 HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes. Pubmed 3.476E-9 5.970E-6 6.759E-5 1.612E-4 5 15
24 1967269 HIV-gp120 can block CD4-class II MHC-mediated adhesion. Pubmed 3.476E-9 5.970E-6 6.759E-5 1.612E-4 5 15
25 3489470 AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications. Pubmed 3.476E-9 5.970E-6 6.759E-5 1.612E-4 5 15
26 9079699 The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway. Pubmed 3.476E-9 5.970E-6 6.759E-5 1.612E-4 5 15
27 8168144 Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help. Pubmed 3.476E-9 5.970E-6 6.759E-5 1.612E-4 5 15
28 19449444 Immunoregulatory effects of HIV-1 Nef protein. Pubmed 4.034E-9 6.682E-6 7.565E-5 1.871E-4 6 32
29 1978941 Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules. Pubmed 5.038E-9 7.537E-6 8.533E-5 2.337E-4 5 16
30 2543930 Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding. Pubmed 5.038E-9 7.537E-6 8.533E-5 2.337E-4 5 16
31 2846691 Inhibition of CD4+ T cell function by the HIV envelope protein, gp120. Pubmed 5.038E-9 7.537E-6 8.533E-5 2.337E-4 5 16
32 25241761 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. Pubmed 7.008E-9 1.016E-5 1.150E-4 3.250E-4 13 371
33 11118314 Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA. Pubmed 9.816E-9 1.301E-5 1.473E-4 4.552E-4 5 18
34 10661406 Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection. Pubmed 9.816E-9 1.301E-5 1.473E-4 4.552E-4 5 18
35 19620308 HIV-1 Nef promotes endocytosis of cell surface MHC class II molecules via a constitutive pathway. Pubmed 9.816E-9 1.301E-5 1.473E-4 4.552E-4 5 18
36 20551380 Proteomics characterization of extracellular space components in the human aorta. Pubmed 1.154E-8 1.486E-5 1.683E-4 5.351E-4 8 101
37 7541827 HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71). Pubmed 1.764E-8 2.211E-5 2.503E-4 8.182E-4 5 20
38 23383108 Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. Pubmed 1.960E-8 2.392E-5 2.709E-4 9.091E-4 8 108
39 12754519 Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. Pubmed 2.094E-8 2.490E-5 2.819E-4 9.711E-4 7 71
40 18985028 Hepatitis C virus infection protein network. Pubmed 2.256E-8 2.610E-5 2.955E-4 1.046E-3 6 42
41 21778700 HIV-1 Gag-virus-like particles induce natural killer cell immune responses via activation and maturation of dendritic cells. Pubmed 2.308E-8 2.610E-5 2.955E-4 1.070E-3 5 21
42 19199708 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Pubmed 2.550E-8 2.815E-5 3.187E-4 1.182E-3 13 414
43 12539042 HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. Pubmed 3.014E-8 3.251E-5 3.681E-4 1.398E-3 6 44
44 23333304 CBFÃ? stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Pubmed 3.281E-8 3.458E-5 3.915E-4 1.521E-3 9 163
45 18977241 Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. Pubmed 3.931E-8 3.963E-5 4.487E-4 1.823E-3 8 118
46 18977241:gr Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. GeneRIF 3.931E-8 3.963E-5 4.487E-4 1.823E-3 8 118
47 17601350 A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. Pubmed 4.200E-8 4.057E-5 4.594E-4 1.948E-3 8 119
48 17601350:gr A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. GeneRIF 4.200E-8 4.057E-5 4.594E-4 1.948E-3 8 119
49 15489916 Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Pubmed 4.771E-8 4.516E-5 5.113E-4 2.213E-3 5 24
50 22889831 Interaction of HLA-DR and CD74 at the cell surface of antigen-presenting cells by single particle image analysis. Pubmed 7.129E-8 5.603E-5 6.344E-4 3.306E-3 3 3
Show 45 more annotations

9: Interaction [Display Chart] 4092 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:C1S C1S interactions 3.377E-7 1.382E-3 1.229E-2 1.382E-3 4 6
2 int:ITGB1 ITGB1 interactions 1.012E-6 2.070E-3 1.841E-2 4.140E-3 10 109
3 int:CD74 CD74 interactions 3.718E-6 4.651E-3 4.136E-2 1.522E-2 5 20
4 int:HLA-DMA HLA-DMA interactions 4.546E-6 4.651E-3 4.136E-2 1.860E-2 4 10
5 int:TKT TKT interactions 5.785E-6 4.734E-3 4.211E-2 2.367E-2 10 132
6 int:CLIC5 CLIC5 interactions 1.051E-5 7.167E-3
6.375E-2
4.300E-2 4 12
7 int:UCHL3 UCHL3 interactions 1.231E-5 7.194E-3
6.398E-2
5.035E-2
8 87
8 int:HSPE1 HSPE1 interactions 1.853E-5 8.611E-3
7.659E-2
7.581E-2
9 120
9 int:EZR EZR interactions 1.894E-5 8.611E-3
7.659E-2
7.750E-2
10 151
10 int:HLA-DRA HLA-DRA interactions 2.374E-5 8.838E-3
7.860E-2
9.713E-2
6 47
11 int:SOD1 SOD1 interactions 2.376E-5 8.838E-3
7.860E-2
9.721E-2
10 155
12 int:DAG1 DAG1 interactions 4.275E-5 1.458E-2
1.296E-1
1.749E-1
6 52
13 int:SELE SELE interactions 4.813E-5 1.515E-2
1.347E-1
1.969E-1
4 17
14 int:MS4A1 MS4A1 interactions 6.128E-5 1.791E-2
1.593E-1
2.507E-1
4 18
15 int:TAGLN2 TAGLN2 interactions 8.714E-5 2.377E-2
2.114E-1
3.566E-1
8 114
16 int:C1R C1R interactions 1.005E-4 2.570E-2
2.285E-1
4.111E-1
3 8
17 int:KCNMA1 KCNMA1 interactions 1.110E-4 2.672E-2
2.377E-1
4.543E-1
10 186
18 int:ITGA5 ITGA5 interactions 1.290E-4 2.779E-2
2.471E-1
5.279E-1
5 40
19 int:GPX4 GPX4 interactions 1.290E-4 2.779E-2
2.471E-1
5.279E-1
5 40
20 int:PEPD PEPD interactions 1.455E-4 2.846E-2
2.531E-1
5.952E-1
5 41
21 int:HRH1 HRH1 interactions 1.530E-4 2.846E-2
2.531E-1
6.260E-1
2 2
22 int:HS3ST3B1 HS3ST3B1 interactions 1.530E-4 2.846E-2
2.531E-1
6.260E-1
2 2
23 int:MSN MSN interactions 1.953E-4 3.423E-2
3.044E-1
7.993E-1
8 128
24 int:KLK3 KLK3 interactions 2.007E-4 3.423E-2
3.044E-1
8.214E-1
4 24
25 int:HLA-DRB1 HLA-DRB1 interactions 2.367E-4 3.874E-2
3.445E-1
9.685E-1
4 25
26 int:ANXA11 ANXA11 interactions 2.803E-4 4.412E-2
3.924E-1
1.000E0
5 47
27 int:HBA1 HBA1 interactions 3.220E-4 4.881E-2
4.341E-1
1.000E0
4 27
Show 22 more annotations

10: Cytoband [Display Chart] 185 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6p21.3 6p21.3 2.176E-4 4.026E-2
2.335E-1
4.026E-2 8 257

11: Transcription Factor Binding Site [Display Chart] 520 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 109 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 588 Histocompatibility complex|C1-set domain containing genenames.org 5.041E-8 5.495E-6 2.897E-5 5.495E-6 7 44
2 591 C1-set domain containing genenames.org 9.185E-7 5.006E-5 2.640E-4 1.001E-4 6 42
3 542 Endogenous ligands genenames.org 2.968E-6 1.079E-4 5.687E-4 3.236E-4 11 237
4 555 Fibronectin type III domain containing|Immunoglobulin like domain containing genenames.org 5.187E-6 1.414E-4 7.454E-4 5.654E-4 9 160
5 593 CD molecules|V-set domain containing|I-set domain containing|Sialic acid binding Ig like lectins genenames.org 4.293E-5 9.358E-4 4.935E-3 4.679E-3 8 161
6 492 Complement system genenames.org 1.821E-4 3.308E-3 1.744E-2 1.985E-2 4 36
7 1227 Phospholipases|HRAS like suppressor family genenames.org 6.125E-4 9.537E-3
5.029E-2
6.676E-2
2 5
8 1179 Complement system|Sushi domain containing genenames.org 1.074E-3 1.463E-2
7.714E-2
1.170E-1
4 57
9 816 Chitinases genenames.org 1.273E-3 1.542E-2
8.129E-2
1.387E-1
2 7
10 1278 SPARC family genenames.org 1.688E-3 1.673E-2
8.822E-2
1.840E-1
2 8
11 556 Fibulins genenames.org 1.688E-3 1.673E-2
8.822E-2
1.840E-1
2 8
12 1234 Complement system|Endogenous ligands|C3 and PZP like, alpha-2-macroglobulin domain containing genenames.org 2.159E-3 1.961E-2
1.034E-1
2.354E-1
2 9
13 739 Serpin peptidase inhibitors genenames.org 3.098E-3 2.542E-2
1.340E-1
3.377E-1
3 37
14 585 Small heat shock proteins genenames.org 3.265E-3 2.542E-2
1.340E-1
3.559E-1
2 11
15 594 CD molecules|V-set domain containing|Immunoglobulin like domain containing genenames.org 4.387E-3 3.188E-2
1.681E-1
4.782E-1
6 193
16 470 Cathepsins genenames.org 6.105E-3 4.159E-2
2.193E-1
6.655E-1
2 15
Show 11 more annotations

13: Coexpression [Display Chart] 6865 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M12225 Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.819E-26 1.249E-22 1.175E-21 1.249E-22 30 205
2 M17471 Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS, non-invasive). MSigDB C2: CGP Curated Gene Sets (v5.1) 9.171E-23 3.148E-19 2.963E-18 6.296E-19 33 351
3 M14507 Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.904E-20 6.645E-17 6.254E-16 1.994E-16 34 454
4 M8513 Genes up-regulated in the normal-like subtype of breast cancer. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.285E-19 2.205E-16 2.075E-15 8.821E-16 34 476
5 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v5.1) 2.881E-19 3.955E-16 3.722E-15 1.978E-15 24 200
6 M10454 Genes up-regulated in pulpal tissue extracted from carious teeth. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.065E-19 4.651E-16 4.377E-15 2.791E-15 26 252
7 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.306E-18 3.243E-15 3.052E-14 2.270E-14 31 425
8 M11620 Genes induced in the liver during hepatitis B (HBV) viral clearance in chimpanzees. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.655E-16 1.420E-13 1.337E-12 1.136E-12 17 101
9 M1919 Genes up-regulated in MEF cells (embryonic fibroblast) with double knockout of the translation repressors 4EBP1 [GeneID=1978] and 4EBP2 [GeneID=1979]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.165E-16 1.652E-13 1.555E-12 1.487E-12 27 356
10 M1278 Genes down-regulated in pulpal tissue extracted from carious teeth. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.706E-16 2.544E-13 2.395E-12 2.544E-12 23 244
11 M5913 Genes up-regulated in response to IFNG [GeneID=3458]. MSigDB H: Hallmark Gene Sets (v5.1) 8.512E-16 4.869E-13 4.583E-12 5.843E-12 21 200
12 M3408 Genes down-regulated in comparison of control microglia cells versus those 24 h after stimulation with IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v5.1) 8.512E-16 4.869E-13 4.583E-12 5.843E-12 21 200
13 M4551 Genes up-regulated in five primary endothelial cell types (lung, aortic, iliac, dermal, and colon) by IFNG [GeneID=3458]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.048E-15 5.534E-13 5.208E-12 7.194E-12 15 77
14 M5389 Genes whose expression increases with age in normal kidney. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.141E-15 5.597E-13 5.267E-12 7.835E-12 30 486
15 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.491E-15 6.822E-13 6.421E-12 1.023E-11 23 260
16 M4995 Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.085E-15 8.948E-13 8.421E-12 1.432E-11 27 390
17 M2144 Genes consistently overexpressed with age, based on meta-analysis of microarray data. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.970E-15 2.365E-12 2.226E-11 4.098E-11 13 55
18 M19391 Genes down-regulated in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.201E-15 2.365E-12 2.226E-11 4.257E-11 29 480
19 M5487 Hepatic graft versus host disease (GVHD), day 7: up-regulated in allogeneic vs syngeneic bone marrow transplant. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.220E-15 3.331E-12 3.135E-11 6.329E-11 16 107
20 M5890 Genes regulated by NF-kB in response to TNF [GeneID=7124]. MSigDB H: Hallmark Gene Sets (v5.1) 1.093E-14 3.752E-12 3.531E-11 7.503E-11 20 200
21 M2240 Genes up-regulated upon overexpression of PARVB [GeneID=29780] in MDA-MB-231 cells (breast cancer) cultured in 3D Matrigel only. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.139E-14 6.993E-12 6.582E-11 1.469E-10 27 429
22 M1459 Genes up-regulated in BEC (blood endothelial cells) compared to LEC (lymphatic endothelial cells). MSigDB C2: CGP Curated Gene Sets (v5.1) 3.890E-14 1.214E-11 1.142E-10 2.670E-10 18 162
23 M3645 Genes up-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.644E-14 1.368E-11 1.288E-10 3.188E-10 27 443
24 M1578 Genes down-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.784E-14 1.368E-11 1.288E-10 3.284E-10 20 216
25 M1804 Genes up-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.349E-14 2.018E-11 1.899E-10 5.045E-10 22 280
26 GSE42021 TREG PLN VS CD24INT TREG THYMUS DN Genes down-regulated in T reg: peripheral lymph nodes versus thymic CD24 int [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v5.1) 1.323E-13 3.493E-11 3.288E-10 9.083E-10 19 200
27 M19541 Genes commonly down-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.823E-13 9.720E-11 9.148E-10 2.624E-9 25 408
28 M2395 Genes up-regulated in pancreatic islets upon knockout of HNF1A [GeneID=6927]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.805E-13 1.423E-10 1.340E-9 3.985E-9 17 163
29 M6921 Top 50 marker genes for glioblastoma multiforme (GBM), a class of high grade glioma. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.667E-13 1.578E-10 1.485E-9 4.577E-9 11 46
30 M2293 Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.996E-13 1.830E-10 1.722E-9 5.489E-9 22 315
31 GSE41978 ID2 KO VS BIM KO KLRG1 LOW EFFECTOR CD8 TCELL UP Genes up-regulated in KLRG1 low [GeneID=10219] CD8 T effector cells during infection: ID2 [GeneID=10219] knockout versus BCL2L11 [GeneID=10018] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.383E-12 2.876E-10 2.707E-9 9.492E-9 18 199
32 GSE36888 UNTREATED VS IL2 TREATED TCELL 17H DN Genes down-regulated in T cells: control versus IL2 [GeneID=3558] stimulation for 17h. MSigDB C7: Immunologic Signatures (v5.1) 1.383E-12 2.876E-10 2.707E-9 9.492E-9 18 199
33 GSE18281 CORTICAL VS MEDULLARY THYMOCYTE UP Genes up-regulated in thymocytes: cortical versus medullary sources. MSigDB C7: Immunologic Signatures (v5.1) 1.383E-12 2.876E-10 2.707E-9 9.492E-9 18 199
34 M3414 Genes down-regulated in comparison of microglia cells 1 h after stimulation with IFNG [GeneID=3458] versus microglia cells 24 h after the stimulation. MSigDB C7: Immunologic Signatures (v5.1) 1.506E-12 2.954E-10 2.781E-9 1.034E-8 18 200
35 GSE42021 CD24HI VS CD24LOW TCONV THYMUS DN Genes down-regulated in thymic T conv: CD24 high [GeneID=100133941] versus CD24 low [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v5.1) 1.506E-12 2.954E-10 2.781E-9 1.034E-8 18 200
36 M13206 Genes down-regulated in TC71 and EWS502 cells (Ewing's sarcoma) by EWSR1-FLI1 [GeneID=2130;2314] as inferred from RNAi knockdown of this fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.589E-12 3.029E-10 2.851E-9 1.091E-8 22 326
37 M19097 Genes up-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.512E-12 6.516E-10 6.133E-9 2.411E-8 26 491
38 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.362E-12 9.687E-10 9.117E-9 3.681E-8 25 460
39 M1666 Strongly down-regulated at 8-96 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.667E-12 1.174E-9 1.104E-8 4.577E-8 13 92
40 M9893 Genes whose expression increases with age in normal kidney, excluding those with higher expression in blood. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.184E-12 1.405E-9 1.322E-8 5.618E-8 18 221
41 GSE42021 TREG VS TCONV PLN UP Genes up-regulated in cells from peripheral lymph nodes: T reg versus T conv. MSigDB C7: Immunologic Signatures (v5.1) 1.609E-11 2.629E-9 2.475E-8 1.104E-7 17 200
42 GSE17301 ACD3 ACD28 VS ACD3 ACD28 AND IFNA5 STIM CD8 TCELL DN Genes down-regulated in CD8 T cells activated by anti-CD3 and anti-CD28 versus those stimulated by IFNA5 [GeneID=3442]. MSigDB C7: Immunologic Signatures (v5.1) 1.609E-11 2.629E-9 2.475E-8 1.104E-7 17 200
43 M17079 Up-regulated genes distinguishing between two subtypes of gastric cancer: advanced (AGC) and early (EGC). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.152E-11 3.435E-9 3.233E-8 1.477E-7 16 175
44 M2504 Genes whose expression changes in Calu-6 cells (lung cancer) by TNF [GeneID=7124] were not affected by p38 inhibitor LY479754. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.358E-11 3.679E-9 3.463E-8 1.619E-7 21 337
45 M10952 Genes up-regulated in the atria of healthy hearts, compared to venticles. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.968E-11 9.105E-9 8.569E-8 4.097E-7 18 249
46 M13256 Genes down-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.459E-11 1.113E-8 1.048E-7 5.121E-7 16 190
47 M14134 Genes down-regulated in ductal carcinoma vs normal ductal breast cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.383E-10 2.020E-8 1.901E-7 9.495E-7 16 198
48 M4632 Genes down-regulated in comparison of CD25- T cells treated with IL4 [GeneID=3565] at day 3 versus untreated CD25- T cells at day 3. MSigDB C7: Immunologic Signatures (v5.1) 1.607E-10 2.206E-8 2.076E-7 1.103E-6 16 200
49 GSE37533 PPARG1 FOXP3 VS PPARG2 FOXP3 TRANSDUCED CD4 TCELL PIOGLITAZONE TREATED DN Genes down-regulated in CD4 [GeneID=920] T cells treated with pioglitazone [PubChem=4829] and over-expressing: FOXP3 [GeneID=50943] and PPARg1 isoform of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943] and PPARg2 form of PPARG [GeneID=5468]. MSigDB C7: Immunologic Signatures (v5.1) 1.607E-10 2.206E-8 2.076E-7 1.103E-6 16 200
50 GSE42021 CD24HI VS CD24INT TREG THYMUS DN Genes down-regulated in thymic T reg: CD24 high [GeneID=100133941] versus CD24 int [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v5.1) 1.607E-10 2.206E-8 2.076E-7 1.103E-6 16 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 3446 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 astrocytes Top 500 All astrocytes Top 500 All Brain Map - Barres 1.064E-45 3.668E-42 3.199E-41 3.668E-42 59 496
2 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 4.144E-35 7.141E-32 6.228E-31 1.428E-31 50 493
3 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 2.804E-26 3.221E-23 2.809E-22 9.662E-23 40 438
4 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 2.564E-25 2.209E-22 1.927E-21 8.837E-22 41 494
5 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 6.701E-23 4.618E-20 4.028E-19 2.309E-19 37 445
6 80Dn SubClass 80Dn 5 Top 500 All 80Dn SubClass 80Dn 5 Top 500 All Brain Map - Allen iN 5.956E-22 2.932E-19 2.557E-18 2.052E-18 37 474
7 80Dn SubClass 80Dn 5 Top 500 Cluster 0 80Dn SubClass 80Dn 5 Top 500 Cluster 0 Brain Map - Allen iN 5.956E-22 2.932E-19 2.557E-18 2.052E-18 37 474
8 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 2.823E-21 1.216E-18 1.061E-17 9.727E-18 37 496
9 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 1.388E-20 5.316E-18 4.637E-17 4.785E-17 35 455
10 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 3.226E-20 1.112E-17 9.695E-17 1.112E-16 35 467
11 astrocytes Top 500 Cluster 4 astrocytes Top 500 Cluster 4 Brain Map - Barres 2.822E-18 8.839E-16 7.710E-15 9.723E-15 22 166
12 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 8.731E-18 2.507E-15 2.187E-14 3.009E-14 32 453
13 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.845E-17 1.019E-14 8.889E-14 1.325E-13 30 410
14 54Dn Top 500 Cluster 1 54Dn Top 500 Cluster 1 Brain Map - Allen iN 5.373E-16 1.323E-13 1.154E-12 1.852E-12 20 164
15 54SK Top 500 All 54SK Top 500 All Brain Map - Allen iN 5.805E-16 1.334E-13 1.163E-12 2.000E-12 31 488
16 GSM777063 500 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 3.777E-15 8.135E-13 7.096E-12 1.302E-11 29 450
17 astrocytes Top 500 Cluster 1 astrocytes Top 500 Cluster 1 Brain Map - Barres 1.296E-14 2.626E-12 2.291E-11 4.465E-11 20 193
18 GSM777050 100 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 1.397E-14 2.675E-12 2.333E-11 4.815E-11 15 87
19 54SK SubClass 54SK 3 Top 500 All 54SK SubClass 54SK 3 Top 500 All Brain Map - Allen iN 2.221E-14 4.028E-12 3.513E-11 7.653E-11 29 482
20 80Dn Top 500 Cluster 2 80Dn Top 500 Cluster 2 Brain Map - Allen iN 3.808E-14 6.562E-12 5.724E-11 1.312E-10 21 231
21 54Dn SubClass 54Dn 2 Top 500 All 54Dn SubClass 54Dn 2 Top 500 All Brain Map - Allen iN 4.382E-14 7.191E-12 6.272E-11 1.510E-10 29 495
22 GSM777046 100 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 7.501E-14 1.175E-11 1.025E-10 2.585E-10 15 97
23 GSM777059 500 Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.111E-13 1.664E-11 1.451E-10 3.827E-10 27 439
24 GSM777055 100 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 2.487E-13 3.571E-11 3.115E-10 8.570E-10 14 86
25 gudmap kidney adult RenalCapsule 200 kidney adult RenalCapsule top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.594E-13 4.954E-11 4.321E-10 1.238E-9 18 176
26 PCBC ratio ECTO blastocyst vs ECTO UCB CD34+Z cfr-2X-p05 ECTO blastocyst vs ECTO UCB CD34+Z-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 4.946E-13 6.555E-11 5.718E-10 1.704E-9 22 294
27 GSM777043 100 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 1.387E-12 1.770E-10 1.544E-9 4.779E-9 14 97
28 gudmap developingKidney e15.5 Ureteral Smooth Musc 1000 k2 DevelopingKidney e15.5 Ureteral Smooth Musc emap-28812 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 7.175E-12 8.830E-10 7.702E-9 2.472E-8 20 270
29 54SK Top 500 Cluster 1 54SK Top 500 Cluster 1 Brain Map - Allen iN 8.096E-12 9.620E-10 8.391E-9 2.790E-8 14 110
30 gudmap kidney adult RenMedVasc Tie2 500 kidney adult RenMedVasc Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.146E-11 1.317E-9 1.148E-8 3.950E-8 24 417
31 GSM854285 500 Myeloid Cells, DC.8-4-11b+.SLN, CD45-APC CD11b-FITC CD11c-eFluor780 CD4-PE CD8a-eF, Lymph Node, avg-2 Immgen.org, GSE15907 1.267E-11 1.408E-9 1.228E-8 4.366E-8 24 419
32 GSM777037 500 Stromal Cells, BEC.SLN, gp38- CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.371E-11 1.477E-9 1.288E-8 4.725E-8 25 459
33 JC fibro 1000 K1 JC fibro top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 1.731E-11 1.808E-9 1.577E-8 5.967E-8 25 464
34 ratio EB vs SC 1000 K1 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 5.203E-11 5.273E-9 4.600E-8 1.793E-7 21 336
35 GSM854243 500 Myeloid Cells, DC.103+11b-.LuLN, MHCII+ CD11c+ CD8- CD11b- CD103+, Lymph Node, avg-3 Immgen.org, GSE15907 6.331E-11 6.129E-9 5.346E-8 2.182E-7 22 376
36 GSM854271 500 Myeloid Cells, DC.103-11b+24-.Lu, MHCII+ CD11c+ CD103- CD11b+ CD24-, Lung, avg-2 Immgen.org, GSE15907 6.403E-11 6.129E-9 5.346E-8 2.207E-7 23 414
37 GSM777032 500 Stromal Cells, BEC.MLN, gp38- CD31+, Lymph Node, avg-5 Immgen.org, GSE15907 7.318E-11 6.816E-9 5.945E-8 2.522E-7 24 456
38 gudmap kidney adult CortVasc Tie2 500 kidney adult CortVasc Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.752E-11 6.928E-9 6.043E-8 2.671E-7 23 418
39 gudmap kidney adult RenalCapsule k1 500 kidney adult RenalCapsule k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.841E-11 6.928E-9 6.043E-8 2.702E-7 18 242
40 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 1000 k1 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 8.391E-11 7.229E-9 6.306E-8 2.892E-7 18 243
41 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 9.151E-11 7.691E-9 6.709E-8 3.153E-7 24 461
42 GSM777059 100 Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.707E-10 1.401E-8 1.222E-7 5.882E-7 12 91
43 gudmap kidney adult RenCorpuscGlomer 500 kidney adult RenCorpuscGlomer top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.952E-10 1.564E-8 1.364E-7 6.726E-7 23 438
44 PCBC ratio ECTO blastocyst vs ECTO amniotic fluid MSC cfr-2X-p05 ECTO blastocyst vs ECTO amniotic fluid MSC-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 2.025E-10 1.586E-8 1.383E-7 6.979E-7 19 290
45 endothelial Top 500 Cluster 4 endothelial Top 500 Cluster 4 Brain Map - Barres 2.237E-10 1.713E-8 1.494E-7 7.708E-7 18 258
46 GSM605834 500 Myeloid Cells, DC.8-4-11b-.MLN, CD11b-FITC CD4-PE CD11c-Alexa750 CD8a-PacificBlue, Lymph Node, avg-2 Immgen.org, GSE15907 2.381E-10 1.784E-8 1.556E-7 8.204E-7 22 403
47 gudmap developingLowerUrinaryTract P2 bladder stroma (LCM) 1000 k3 DevelopingLowerUrinaryTract P2 bladder stroma (LCM) emap-30396 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.764E-10 2.027E-8 1.768E-7 9.525E-7 17 229
48 GSM854287 500 Myeloid Cells, DC.8-4-11b+.SLN, CD11b-FITC CD4-PE CD11c-eFluor780 CD8a-eFluor450 C, Lymph Node, avg-1 Immgen.org, GSE15907 2.870E-10 2.061E-8 1.797E-7 9.892E-7 22 407
49 gudmap kidney adult RenalCapsule k2 1000 kidney adult RenalCapsule k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.230E-10 2.226E-8 1.942E-7 1.113E-6 21 371
50 GSM777063 100 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 3.230E-10 2.226E-8 1.942E-7 1.113E-6 12 96
Show 45 more annotations

15: Computational [Display Chart] 384 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 3.511E-14 1.348E-11 8.804E-11 1.348E-11 34 423
2 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 1.123E-11 2.156E-9 1.407E-8 4.311E-9 29 378
3 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 1.895E-11 2.426E-9 1.584E-8 7.278E-9 22 216
4 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 5.966E-11 5.727E-9 3.739E-8 2.291E-8 27 351
5 module 75 Genes in module 75 MSigDb: C4 - CM: Cancer Modules 1.356E-10 1.041E-8 6.798E-8 5.206E-8 28 391
6 module 46 Genes in module 46 MSigDb: C4 - CM: Cancer Modules 2.501E-9 1.601E-7 1.045E-6 9.603E-7 26 386
7 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 1.425E-8 7.816E-7 5.103E-6 5.471E-6 24 361
8 module 6 Genes in module 6 MSigDb: C4 - CM: Cancer Modules 5.589E-7 2.683E-5 1.752E-4 2.146E-4 23 407
9 module 44 Genes in module 44 MSigDb: C4 - CM: Cancer Modules 6.522E-7 2.783E-5 1.817E-4 2.504E-4 20 319
10 module 58 Genes in module 58 MSigDb: C4 - CM: Cancer Modules 1.125E-6 4.320E-5 2.821E-4 4.320E-4 6 21
11 module 130 Genes in module 130 MSigDb: C4 - CM: Cancer Modules 2.033E-6 6.529E-5 4.263E-4 7.807E-4 6 23
12 module 176 Genes in module 176 MSigDb: C4 - CM: Cancer Modules 2.040E-6 6.529E-5 4.263E-4 7.835E-4 16 227
13 module 208 Genes in module 208 MSigDb: C4 - CM: Cancer Modules 7.344E-6 2.169E-4 1.416E-3 2.820E-3 11 120
14 module 112 Genes in module 112 MSigDb: C4 - CM: Cancer Modules 1.009E-5 2.767E-4 1.807E-3 3.874E-3 16 257
15 module 19 Genes in module 19 MSigDb: C4 - CM: Cancer Modules 2.441E-5 6.249E-4 4.080E-3 9.373E-3 17 307
16 module 241 Genes in module 241 MSigDb: C4 - CM: Cancer Modules 3.029E-5 7.269E-4 4.746E-3 1.163E-2 8 71
17 GNF2 PTX3 Neighborhood of PTX3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.251E-5 7.344E-4 4.795E-3 1.248E-2 6 36
18 GNF2 CDH11 Neighborhood of CDH11 MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.094E-5 1.300E-3 8.488E-3 2.340E-2 5 25
19 module 324 Genes in module 324 MSigDb: C4 - CM: Cancer Modules 9.348E-5 1.698E-3 1.109E-2 3.590E-2 10 131
20 module 292 Genes in module 292 MSigDb: C4 - CM: Cancer Modules 9.965E-5 1.698E-3 1.109E-2 3.826E-2 10 132
21 GCM AQP4 Neighborhood of AQP4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.050E-4 1.698E-3 1.109E-2 4.032E-2 6 44
22 module 291 Genes in module 291 MSigDb: C4 - CM: Cancer Modules 1.055E-4 1.698E-3 1.109E-2 4.049E-2 7 63
23 module 436 Genes in module 436 MSigDb: C4 - CM: Cancer Modules 1.062E-4 1.698E-3 1.109E-2 4.076E-2 10 133
24 module 171 Genes in module 171 MSigDb: C4 - CM: Cancer Modules 1.062E-4 1.698E-3 1.109E-2 4.076E-2 10 133
25 module 174 Genes in module 174 MSigDb: C4 - CM: Cancer Modules 1.944E-4 2.986E-3 1.950E-2
7.465E-2
8 92
26 module 345 Genes in module 345 MSigDb: C4 - CM: Cancer Modules 2.561E-4 3.782E-3 2.469E-2
9.833E-2
9 121
27 module 427 Genes in module 427 MSigDb: C4 - CM: Cancer Modules 5.126E-4 7.290E-3 4.760E-2
1.968E-1
8 106
28 module 480 Genes in module 480 MSigDb: C4 - CM: Cancer Modules 8.407E-4 1.153E-2
7.528E-2
3.228E-1
7 88
29 GNF2 LYN Neighborhood of LYN MSigDb: C4 - CGN: Cancer Gene Neighborhood 9.899E-4 1.308E-2
8.542E-2
3.801E-1
4 26
30 module 293 Genes in module 293 MSigDb: C4 - CM: Cancer Modules 1.022E-3 1.308E-2
8.542E-2
3.925E-1
3 12
31 module 143 Genes in module 143 MSigDb: C4 - CM: Cancer Modules 1.648E-3 2.042E-2
1.333E-1
6.329E-1
3 14
32 module 24 Genes in module 24 MSigDb: C4 - CM: Cancer Modules 1.927E-3 2.313E-2
1.510E-1
7.401E-1
17 445
33 GNF2 MMP1 Neighborhood of MMP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.195E-3 2.554E-2
1.668E-1
8.430E-1
4 32
34 module 223 Genes in module 223 MSigDb: C4 - CM: Cancer Modules 3.083E-3 3.482E-2
2.273E-1
1.000E0
8 140
35 module 204 Genes in module 204 MSigDb: C4 - CM: Cancer Modules 3.211E-3 3.523E-2
2.300E-1
1.000E0
6 83
36 module 129 Genes in module 129 MSigDb: C4 - CM: Cancer Modules 4.662E-3 4.973E-2
3.247E-1
1.000E0
10 217
Show 31 more annotations

16: MicroRNA [Display Chart] 1273 annotations before applied cutoff / 19844 genes in category

No results to display

17: Drug [Display Chart] 26894 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 D017258 Medroxyprogesterone Acetate CTD 1.370E-14 3.685E-10 3.971E-9 3.685E-10 26 390
2 D015056 1-Methyl-3-isobutylxanthine CTD 6.598E-12 6.570E-8 7.080E-7 1.775E-7 23 391
3 C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone CTD 7.329E-12 6.570E-8 7.080E-7 1.971E-7 21 320
4 1122 UP cytochalasin B; Up 200; 20.8uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.549E-11 1.041E-7 1.122E-6 4.165E-7 16 173
5 C488369 dasatinib CTD 4.713E-11 2.305E-7 2.484E-6 1.267E-6 24 472
6 D000069439 Dasatinib CTD 5.142E-11 2.305E-7 2.484E-6 1.383E-6 24 474
7 D008769 Methylnitronitrosoguanidine CTD 1.239E-10 4.715E-7 5.081E-6 3.333E-6 18 263
8 D016559 Tacrolimus CTD 1.430E-10 4.715E-7 5.081E-6 3.846E-6 20 337
9 C487081 belinostat CTD 1.578E-10 4.715E-7 5.081E-6 4.243E-6 22 417
10 C011907 melamine CTD 1.923E-10 5.171E-7 5.573E-6 5.171E-6 8 28
11 D014302 Trinitrobenzenesulfonic Acid CTD 2.644E-10 6.465E-7 6.968E-6 7.112E-6 21 388
12 C016766 sulforafan CTD 3.763E-10 8.433E-7 9.088E-6 1.012E-5 23 479
13 C056507 gemcitabine CTD 5.831E-10 1.206E-6 1.300E-5 1.568E-5 17 254
14 CID000004242 NSC-343257 Stitch 1.018E-9 1.956E-6 2.107E-5 2.738E-5 16 229
15 C113580 U 0126 CTD 1.208E-9 2.165E-6 2.333E-5 3.248E-5 21 422
16 6711 UP Puromycin dihydrochloride [58-58-2]; Up 200; 7.4uM; PC3; HT HG-U133A Broad Institute CMAP 2.722E-9 4.575E-6 4.930E-5 7.319E-5 14 179
17 C066075 vanadium pentoxide CTD 3.211E-9 5.079E-6 5.474E-5 8.635E-5 11 98
18 D005473 Fluoxetine CTD 3.519E-9 5.257E-6 5.666E-5 9.463E-5 18 324
19 2215 UP Disulfiram [97-77-8]; Up 200; 13.4uM; MCF7; HT HG-U133A Broad Institute CMAP 4.173E-9 5.907E-6 6.366E-5 1.122E-4 14 185
20 D011692 Puromycin Aminonucleoside CTD 6.736E-9 9.058E-6 9.762E-5 1.812E-4 14 192
21 3771 UP Lanatoside C [17575-22-3]; Up 200; 4uM; PC3; HT HG-U133A Broad Institute CMAP 7.467E-9 9.562E-6 1.031E-4 2.008E-4 13 162
22 CID000000899 N-acetylhexosamine Stitch 8.732E-9 9.843E-6 1.061E-4 2.348E-4 21 472
23 CID000006124 dimethylnitrosamine Stitch 8.776E-9 9.843E-6 1.061E-4 2.360E-4 14 196
24 C013698 tallow CTD 8.784E-9 9.843E-6 1.061E-4 2.362E-4 16 266
25 C044946 benazepril CTD 9.502E-9 1.022E-5 1.102E-4 2.555E-4 10 84
26 5310 UP Puromycin dihydrochloride [58-58-2]; Up 200; 7.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.159E-8 1.199E-5 1.292E-4 3.116E-4 13 168
27 C059765 amphotericin B, deoxycholate drug combination CTD 2.234E-8 2.193E-5 2.364E-4 6.007E-4 18 365
28 C430898 AGN 194204 CTD 2.360E-8 2.193E-5 2.364E-4 6.348E-4 12 147
29 D010656 Phenylephrine CTD 2.365E-8 2.193E-5 2.364E-4 6.360E-4 21 500
30 D007052 Ibuprofen CTD 3.582E-8 3.211E-5 3.461E-4 9.634E-4 16 294
31 1520 UP Azacyclonol [115-46-8]; Up 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 3.970E-8 3.444E-5 3.711E-4 1.068E-3 12 154
32 1068 UP thioridazine hydrochloride; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 4.266E-8 3.585E-5 3.864E-4 1.147E-3 12 155
33 D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine CTD 4.527E-8 3.689E-5 3.976E-4 1.217E-3 16 299
34 C010176 halofuginone CTD 4.978E-8 3.937E-5 4.243E-4 1.339E-3 11 127
35 D008345 Manganese CTD 7.644E-8 5.873E-5 6.330E-4 2.056E-3 19 441
36 3310 UP Puromycin dihydrochloride [58-58-2]; Up 200; 7.4uM; MCF7; HT HG-U133A Broad Institute CMAP 8.522E-8 6.031E-5 6.500E-4 2.292E-3 12 165
37 2439 UP Menadione [58-27-5]; Up 200; 23.2uM; HL60; HT HG-U133A Broad Institute CMAP 8.522E-8 6.031E-5 6.500E-4 2.292E-3 12 165
38 3770 UP Helveticoside [630-64-8]; Up 200; 7.4uM; PC3; HT HG-U133A Broad Institute CMAP 8.522E-8 6.031E-5 6.500E-4 2.292E-3 12 165
39 C011559 tributyltin CTD 9.691E-8 6.575E-5 7.086E-4 2.606E-3 16 316
40 C515055 darinaparsin CTD 9.780E-8 6.575E-5 7.086E-4 2.630E-3 9 81
41 D010938 Plant Oils CTD 1.006E-7 6.598E-5 7.110E-4 2.705E-3 20 496
42 D017382 Reactive Oxygen Species CTD 1.056E-7 6.616E-5 7.130E-4 2.841E-3 16 318
43 C066229 prolinedithiocarbamate CTD 1.058E-7 6.616E-5 7.130E-4 2.845E-3 8 59
44 C008493 methylselenic acid CTD 1.157E-7 7.072E-5 7.622E-4 3.112E-3 18 407
45 887 UP celastrol; Up 200; 2.5uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.261E-7 7.374E-5 7.947E-4 3.392E-3 12 171
46 3318 UP Hexetidine [141-94-6]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP 1.261E-7 7.374E-5 7.947E-4 3.392E-3 12 171
47 6989 UP thioridazine hydrochloride; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.344E-7 7.378E-5 7.952E-4 3.615E-3 12 172
48 C440499 lipopolysaccharide, Escherichia coli 0111 B4 CTD 1.344E-7 7.378E-5 7.952E-4 3.615E-3 12 172
49 906 UP calmidazolium chloride; Up 200; 5uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.344E-7 7.378E-5 7.952E-4 3.615E-3 12 172
50 949 UP 5255229; Up 200; 13uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.432E-7 7.617E-5 8.208E-4 3.852E-3 12 173
Show 45 more annotations

18: Disease [Display Chart] 3085 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0034069 Pulmonary Fibrosis DisGeNET Curated 2.906E-10 8.967E-7 7.722E-6 8.967E-7 21 317
2 umls:C0042373 Vascular Diseases DisGeNET Curated 8.252E-9 8.910E-6 7.673E-5 2.546E-5 20 346
3 umls:C0242383 Age related macular degeneration DisGeNET Curated 8.665E-9 8.910E-6 7.673E-5 2.673E-5 20 347
4 umls:C0037274 Dermatologic disorders DisGeNET Curated 2.658E-8 1.704E-5 1.468E-4 8.201E-5 20 371
5 umls:C0701807 Acute anterior uveitis DisGeNET BeFree 3.381E-8 1.704E-5 1.468E-4 1.043E-4 8 42
6 umls:C2936349 Plaque, Amyloid DisGeNET Curated 3.469E-8 1.704E-5 1.468E-4 1.070E-4 15 207
7 umls:C0017601 Glaucoma DisGeNET Curated 3.867E-8 1.704E-5 1.468E-4 1.193E-4 14 179
8 umls:C0019061 Hemolytic-Uremic Syndrome DisGeNET Curated 7.171E-8 2.766E-5 2.382E-4 2.212E-4 8 46
9 umls:C1519670 Tumor Angiogenesis DisGeNET BeFree 1.057E-7 3.325E-5 2.863E-4 3.261E-4 21 443
10 umls:C0162871 Aortic Aneurysm, Abdominal DisGeNET Curated 1.078E-7 3.325E-5 2.863E-4 3.325E-4 12 137
11 umls:C0497406 Overweight DisGeNET Curated 2.227E-7 6.246E-5 5.379E-4 6.871E-4 14 206
12 umls:C0024143 Lupus Nephritis DisGeNET Curated 2.669E-7 6.861E-5 5.908E-4 8.233E-4 13 178
13 umls:C0856169 Endothelial dysfunction DisGeNET BeFree 3.974E-7 9.431E-5 8.122E-4 1.226E-3 14 216
14 umls:C0007193 Cardiomyopathy, Dilated DisGeNET Curated 5.305E-7 1.169E-4 1.007E-3 1.637E-3 18 366
15 umls:C0677607 Hashimoto Disease DisGeNET Curated 6.390E-7 1.287E-4 1.108E-3 1.971E-3 10 106
16 umls:C0007115 Malignant neoplasm of thyroid DisGeNET BeFree 6.673E-7 1.287E-4 1.108E-3 2.059E-3 20 453
17 umls:C0002726 Amyloidosis DisGeNET Curated 1.157E-6 2.092E-4 1.802E-3 3.571E-3 10 113
18 umls:C0014072 Experimental Autoimmune Encephalomyelitis DisGeNET Curated 1.221E-6 2.092E-4 1.802E-3 3.766E-3 17 348
19 umls:C0034067 Pulmonary Emphysema DisGeNET Curated 1.431E-6 2.189E-4 1.885E-3 4.415E-3 12 174
20 umls:C1621958 Glioblastoma Multiforme DisGeNET BeFree 1.461E-6 2.189E-4 1.885E-3 4.507E-3 19 434
21 umls:C0003486 Aortic Aneurysm DisGeNET Curated 1.490E-6 2.189E-4 1.885E-3 4.596E-3 13 207
22 umls:C0221505 Lesion of brain DisGeNET BeFree 1.811E-6 2.539E-4 2.187E-3 5.586E-3 8 69
23 umls:C0268731 Renal glomerular disease DisGeNET BeFree 2.078E-6 2.730E-4 2.351E-3 6.409E-3 9 94
24 umls:C1800706 Idiopathic Pulmonary Fibrosis DisGeNET Curated 2.123E-6 2.730E-4 2.351E-3 6.551E-3 16 323
25 umls:C0333463 Senile Plaques DisGeNET Curated 2.744E-6 3.310E-4 2.850E-3 8.464E-3 14 254
26 umls:C0036202 Sarcoidosis DisGeNET Curated 2.789E-6 3.310E-4 2.850E-3 8.605E-3 13 219
27 umls:C0151650 Renal fibrosis DisGeNET BeFree 3.402E-6 3.887E-4 3.347E-3 1.050E-2 11 157
28 umls:C0002390 Extrinsic allergic alveolitis DisGeNET Curated 4.347E-6 4.789E-4 4.124E-3 1.341E-2 5 21
29 umls:C0019202 Hepatolenticular Degeneration DisGeNET Curated 4.885E-6 5.197E-4 4.476E-3 1.507E-2 7 56
30 umls:C0003507 Aortic Valve Stenosis DisGeNET BeFree 5.602E-6 5.760E-4 4.961E-3 1.728E-2 8 80
31 umls:C0339573 Glaucoma, Primary Open Angle DisGeNET Curated 6.174E-6 5.982E-4 5.152E-3 1.905E-2 11 167
32 umls:C3542024 AORTIC VALVE DISEASE 2 DisGeNET Curated 6.205E-6 5.982E-4 5.152E-3 1.914E-2 7 58
33 umls:C0948089 Acute Coronary Syndrome DisGeNET Curated 6.622E-6 6.191E-4 5.331E-3 2.043E-2 13 237
34 umls:C0812413 Malignant Pleural Mesothelioma DisGeNET BeFree 7.588E-6 6.885E-4 5.929E-3 2.341E-2 13 240
35 umls:C0729233 Dissecting aneurysm of the thoracic aorta DisGeNET BeFree 9.136E-6 8.007E-4 6.896E-3 2.818E-2 11 174
36 umls:C0403416 Idiopathic crescentic glomerulonephritis DisGeNET BeFree 9.344E-6 8.007E-4 6.896E-3 2.883E-2 6 41
37 umls:C0013537 Eclampsia DisGeNET BeFree 1.074E-5 8.958E-4 7.714E-3 3.314E-2 11 177
38 umls:C0239946 Fibrosis, Liver DisGeNET BeFree 1.124E-5 9.125E-4 7.858E-3 3.467E-2 15 327
39 umls:C0555198 Malignant Glioma DisGeNET BeFree 1.163E-5 9.198E-4 7.921E-3 3.587E-2 17 412
40 umls:C0151744 Myocardial Ischemia DisGeNET Curated 1.200E-5 9.254E-4 7.969E-3 3.702E-2 17 413
41 umls:C0037286 Skin Neoplasms DisGeNET Curated 1.329E-5 9.998E-4 8.610E-3 4.099E-2 12 216
42 umls:C0025500 Mesothelioma DisGeNET Curated 1.444E-5 1.061E-3 9.134E-3 4.454E-2 15 334
43 umls:C0028880 Odontogenic Tumors DisGeNET BeFree 1.625E-5 1.166E-3 1.004E-2
5.014E-2
5 27
44 umls:C0752347 Lewy Body Disease DisGeNET Curated 1.900E-5 1.332E-3 1.147E-2
5.862E-2
9 123
45 umls:C2931418 Bare lymphocyte syndrome 2 DisGeNET Curated 2.344E-5 1.572E-3 1.354E-2
7.232E-2
5 29
46 umls:C0242583 Bare Lymphocyte Syndrome DisGeNET BeFree 2.344E-5 1.572E-3 1.354E-2
7.232E-2
5 29
47 umls:C0039103 Synovitis DisGeNET Curated 2.719E-5 1.784E-3 1.537E-2
8.387E-2
8 99
48 umls:C0243026 Sepsis DisGeNET Curated 2.942E-5 1.853E-3 1.596E-2
9.076E-2
17 443
49 umls:C1290884 Inflammatory disorder DisGeNET BeFree 2.943E-5 1.853E-3 1.596E-2
9.078E-2
12 234
50 umls:C0024530 Malaria DisGeNET Curated 3.116E-5 1.922E-3 1.656E-2
9.612E-2
18 491
Show 45 more annotations