Toppgene analysis for aggregated_1964_log, IC22, negative side

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1: GO: Molecular Function [Display Chart] 184 annotations before applied cutoff / 18819 genes in category

No results to display

2: GO: Biological Process [Display Chart] 1460 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 1.959E-6 1.561E-3 1.227E-2 2.860E-3 4 46
2 GO:1901185 negative regulation of ERBB signaling pathway 2.138E-6 1.561E-3 1.227E-2 3.121E-3 4 47
3 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 2.301E-5 9.631E-3
7.573E-2
 3.359E-2 4 85
4 GO:1901184 regulation of ERBB signaling pathway 2.639E-5 9.631E-3
7.573E-2
 3.852E-2 4 88
5 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway 3.761E-5 1.098E-2
8.636E-2
5.491E-2
 2 5
6 GO:0060449 bud elongation involved in lung branching 7.878E-5 1.917E-2
1.507E-1
1.150E-1
 2 7
7 GO:0007173 epidermal growth factor receptor signaling pathway 1.323E-4 2.690E-2
2.115E-1
1.932E-1
 4 133
8 GO:0002683 negative regulation of immune system process 1.640E-4 2.690E-2
2.115E-1
2.394E-1
 6 424
9 GO:1901629 regulation of presynaptic membrane organization 1.682E-4 2.690E-2
2.115E-1
2.456E-1
 2 10
10 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway 2.053E-4 2.690E-2
2.115E-1
2.998E-1
 2 11
11 GO:0051966 regulation of synaptic transmission, glutamatergic 2.119E-4 2.690E-2
2.115E-1
3.094E-1
 3 59
12 GO:0038127 ERBB signaling pathway 2.211E-4 2.690E-2
2.115E-1
3.228E-1
 4 152
13 GO:0061029 eyelid development in camera-type eye 3.900E-4 4.067E-2
3.198E-1
5.694E-1
 2 15
14 GO:0097090 presynaptic membrane organization 3.900E-4 4.067E-2
3.198E-1
5.694E-1
 2 15
15 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 4.452E-4 4.333E-2
3.407E-1
6.500E-1
 2 16
Show 10 more annotations

3: GO: Cellular Component [Display Chart] 158 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0022626 cytosolic ribosome 7.128E-5 1.037E-2
5.853E-2
 1.126E-2 4 119
2 GO:0030139 endocytic vesicle 1.313E-4 1.037E-2
5.853E-2
 2.074E-2 5 266
3 GO:0030666 endocytic vesicle membrane 2.079E-4 1.095E-2
6.178E-2
 3.284E-2 4 157
4 GO:0031252 cell leading edge 7.528E-4 2.508E-2
1.415E-1
1.189E-1
 5 389
5 GO:0044445 cytosolic part 9.526E-4 2.508E-2
1.415E-1
1.505E-1
 4 235
6 GO:0005840 ribosome 9.526E-4 2.508E-2
1.415E-1
1.505E-1
 4 235
7 GO:0044228 host cell surface 1.878E-3 3.709E-2
2.093E-1
2.967E-1
 1 1
8 GO:0097489 multivesicular body, internal vesicle lumen 1.878E-3 3.709E-2
2.093E-1
2.967E-1
 1 1
Show 3 more annotations

4: Human Phenotype [Display Chart] 78 annotations before applied cutoff / 4410 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 1110 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0001168 abnormal prostate gland epithelium morphology 3.720E-5 4.129E-2
3.134E-1
 4.129E-2 3 23

6: Domain [Display Chart] 305 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PD007152 TSC-22 Dip Bun ProDom 2.149E-5 1.638E-3 1.032E-2 6.554E-3 2 4
2 PF01166 TSC22 Pfam 2.149E-5 1.638E-3 1.032E-2 6.554E-3 2 4
3 PS01289 TSC22 PROSITE 2.149E-5 1.638E-3 1.032E-2 6.554E-3 2 4
4 IPR000580 TSC-22 Dip Bun InterPro 2.149E-5 1.638E-3 1.032E-2 6.554E-3 2 4
5 PF05210 Sprouty Pfam 7.493E-5 3.265E-3 2.057E-2 2.285E-2 2 7
6 PS51227 SPR PROSITE 7.493E-5 3.265E-3 2.057E-2 2.285E-2 2 7
7 IPR007875 Sprouty InterPro 7.493E-5 3.265E-3 2.057E-2 2.285E-2 2 7
8 IPR000719 Prot kinase dom InterPro 3.070E-4 1.087E-2
6.845E-2
9.363E-2
 6 489
9 PS50011 PROTEIN KINASE DOM PROSITE 3.207E-4 1.087E-2
6.845E-2
9.780E-2
 6 493
10 IPR017441 Protein kinase ATP BS InterPro 7.424E-4 1.954E-2
1.231E-1
2.264E-1
 5 379
11 PS00107 PROTEIN KINASE ATP PROSITE 1.740E-3 1.954E-2
1.231E-1
5.306E-1
 5 459
12 PF08212 Lipocalin 2 Pfam 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
13 IPR033027 DSCAM ver InterPro 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
14 PS00939 RIBOSOMAL L1E PROSITE 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
15 IPR030709 Protocadherin-17 InterPro 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
16 PF11605 Vps36 ESCRT-II Pfam 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
17 IPR025755 Ribos L4 C dom InterPro 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
18 PS51495 GLUE PROSITE 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
19 IPR028788 CDK6 InterPro 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
20 IPR033596 ADAM19 InterPro 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
21 IPR030799 LRP4 InterPro 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
22 IPR026222 ApoD vertbrte InterPro 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
23 IPR030783 SPRY1 InterPro 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
24 IPR023438 Ribosomal L24e InterPro 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
25 IPR021648 GLUE dom InterPro 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
26 PF14374 Ribos L4 asso C Pfam 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
27 IPR024546 Ribosome biogen RLP24 InterPro 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
28 IPR002969 ApolipopD InterPro 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
29 IPR013000 Ribosomal L4/L1e euk/arc CS InterPro 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
30 IPR030780 SPRY2 InterPro 1.922E-3 1.954E-2
1.231E-1
5.861E-1
 1 1
31 IPR019397 Uncharacterised TMEM39 InterPro 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
32 IPR011876 IsopentenylPP isomerase typ1 InterPro 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
33 IPR000988 Ribosomal L24e-rel InterPro 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
34 IPR023574 Ribosomal L4 dom InterPro 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
35 PD004466 Ribosomal S27e ProDom 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
36 IPR007286 EAP30 InterPro 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
37 IPR023442 Ribosomal L24e CS InterPro 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
38 IPR000592 Ribosomal S27e InterPro 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
39 PF10271 Tmp39 Pfam 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
40 PF00573 Ribosomal L4 Pfam 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
41 PF04157 EAP30 Pfam 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
42 PF01246 Ribosomal L24e Pfam 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
43 3.40.1370.10 - Gene3D 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
44 PS01168 RIBOSOMAL S27E PROSITE 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
45 PS01073 RIBOSOMAL L24E PROSITE 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
46 2.30.170.20 - Gene3D 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
47 PF01667 Ribosomal S27e Pfam 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
48 IPR022271 Lipocalin ApoD InterPro 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
49 IPR002136 Ribosomal L4/L1e InterPro 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
50 IPR023407 Ribosomal S27e Zn-bd dom InterPro 3.839E-3 2.252E-2
1.419E-1
1.000E0
 1 2
Show 45 more annotations

7: Pathway [Display Chart] 418 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 106342 EGFR downregulation BioSystems: REACTOME 4.221E-7 1.765E-4 1.167E-3 1.765E-4 4 28
2 M1389 Sprouty regulation of tyrosine kinase signals MSigDB C2 BIOCARTA (v5.1) 8.465E-6 1.769E-3 1.170E-2 3.539E-3 3 18
3 138013 Internalization of ErbB1 BioSystems: Pathway Interaction Database 6.060E-5 8.443E-3
5.584E-2
 2.533E-2 3 34
4 M18837 Map Kinase Inactivation of SMRT Corepressor MSigDB C2 BIOCARTA (v5.1) 2.735E-4 2.858E-2
1.890E-1
1.143E-1
 2 11
5 M16973 CBL mediated ligand-induced downregulation of EGF receptors MSigDB C2 BIOCARTA (v5.1) 3.868E-4 3.233E-2
2.138E-1
1.617E-1
 2 13
6 106337 Signaling by EGFR BioSystems: REACTOME 6.339E-4 3.456E-2
2.286E-1
2.650E-1
 4 176
7 198782 EGFR1 Signaling Pathway BioSystems: WikiPathways 6.476E-4 3.456E-2
2.286E-1
2.707E-1
 4 177
8 530768 Signaling by EGFR in Cancer BioSystems: REACTOME 6.614E-4 3.456E-2
2.286E-1
2.765E-1
 4 178
9 672458 Signaling Pathways in Glioblastoma BioSystems: WikiPathways 7.761E-4 3.605E-2
2.384E-1
3.244E-1
 3 80
10 102279 Endocytosis BioSystems: KEGG 1.081E-3 4.519E-2
2.989E-1
4.519E-1
 4 203
Show 5 more annotations

8: Pubmed [Display Chart] 10163 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15962011 Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. Pubmed 1.943E-10 1.975E-6 1.936E-5 1.975E-6 4 13
2 12593796 hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl. Pubmed 7.854E-9 3.991E-5 3.913E-4 7.982E-5 3 6
3 11983899 The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins. Pubmed 1.374E-8 4.654E-5 4.563E-4 1.396E-4 3 7
4 25873175 AXL mediates resistance to PI3K¿ inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas. Pubmed 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
5 12234920:gr Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling. GeneRIF 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
6 15962011:gr Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. GeneRIF 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
7 22328578:gr Spry1 and spry2 are essential for development of the temporomandibular joint. GeneRIF 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
8 22751098 Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer. Pubmed 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
9 21743007:gr Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation. GeneRIF 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
10 20237272:gr Repression of Fgf signaling by sprouty1-2 regulates cortical patterning in two distinct regions and times. GeneRIF 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
11 21806979:gr Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo. GeneRIF 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
12 23921085 The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells. Pubmed 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
13 26475093 Coexpression of receptor tyrosine kinase AXL and EGFR in human primary lung adenocarcinomas. Pubmed 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
14 20624167:gr Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells. GeneRIF 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
15 11983899:gr The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins. GeneRIF 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
16 16954433:gr Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma. GeneRIF 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
17 20956544 ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells. Pubmed 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
18 23150596:gr Sprouty genes function in suppression of prostate tumorigenesis. GeneRIF 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
19 20624167 Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells. Pubmed 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
20 20956544:gr ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells. GeneRIF 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
21 22751098:gr Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer. GeneRIF 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
22 16954433 Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma. Pubmed 5.512E-7 2.546E-4 2.496E-3 5.602E-3 2 2
23 17516543:gr Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells. GeneRIF 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
24 12218189:gr Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. GeneRIF 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
25 21635887 CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor. Pubmed 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
26 17320394:gr Spatial regulation of EGFR signaling by Sprouty2. GeneRIF 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
27 23074222:gr Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses. GeneRIF 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
28 21362415:gr Sprouty1 and Sprouty2 limit both the size of the otic placode and hindbrain Wnt8a by antagonizing FGF signaling. GeneRIF 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
29 15950061:gr Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching. GeneRIF 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
30 22649008 SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis. Pubmed 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
31 20877636 Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain. Pubmed 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
32 22833562:gr CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies. GeneRIF 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
33 9458049 sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Pubmed 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
34 12734385 Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization. Pubmed 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
35 21275903:gr ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking. GeneRIF 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
36 12593795 Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops. Pubmed 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
37 19364817:gr Cell density-dependent inhibition of epidermal growth factor receptor signaling by p38alpha mitogen-activated protein kinase via Sprouty2 downregulation. GeneRIF 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
38 11894095:gr Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. GeneRIF 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
39 22649008:gr SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis. GeneRIF 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
40 20877636:gr Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain. GeneRIF 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
41 16246327 The Cbl RING finger C-terminal flank controls epidermal growth factor receptor fate downstream of receptor ubiquitination. Pubmed 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
42 15950061 Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching. Pubmed 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
43 19864419 HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2. Pubmed 1.653E-6 3.906E-4 3.830E-3 1.680E-2 2 3
44 16849543 Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors. Pubmed 3.304E-6 6.458E-4 6.331E-3 3.358E-2 2 4
45 23650389:gr Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2. GeneRIF 3.304E-6 6.458E-4 6.331E-3 3.358E-2 2 4
46 18048363 Evidence that sprouty 2 is necessary for sarcoma formation by H-Ras oncogene-transformed human fibroblasts. Pubmed 3.304E-6 6.458E-4 6.331E-3 3.358E-2 2 4
47 20719962:gr Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C. GeneRIF 3.304E-6 6.458E-4 6.331E-3 3.358E-2 2 4
48 23650389 Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2. Pubmed 3.304E-6 6.458E-4 6.331E-3 3.358E-2 2 4
49 10887178 Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain. Pubmed 3.304E-6 6.458E-4 6.331E-3 3.358E-2 2 4
50 26026961 Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression. Pubmed 3.304E-6 6.458E-4 6.331E-3 3.358E-2 2 4
Show 45 more annotations

9: Interaction [Display Chart] 1913 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:HEXIM2 HEXIM2 interactions 1.419E-5 1.585E-2
1.289E-1
 2.714E-2 3 22
2 int:SOS1 SOS1 interactions 1.657E-5 1.585E-2
1.289E-1
 3.171E-2 4 71
3 int:CBLB CBLB interactions 2.531E-5 1.614E-2
1.313E-1
 4.843E-2 4 79
4 int:RAF1 RAF1 interactions 4.488E-5 2.146E-2
1.746E-1
8.586E-2
 5 183
5 int:SPRY3 SPRY3 interactions 9.614E-5 3.219E-2
2.618E-1
1.839E-1
 2 7
6 int:SPRY1 SPRY1 interactions 1.027E-4 3.219E-2
2.618E-1
1.964E-1
 3 42
7 int:SPRY2 SPRY2 interactions 1.178E-4 3.219E-2
2.618E-1
2.253E-1
 4 117
8 int:NCK2 NCK2 interactions 1.821E-4 3.927E-2
3.194E-1
3.484E-1
 4 131
9 int:GAS6 GAS6 interactions 2.052E-4 3.927E-2
3.194E-1
3.925E-1
 2 10
10 int:CBL CBL interactions 2.219E-4 3.927E-2
3.194E-1
4.244E-1
 5 257
11 int:FIGNL1 FIGNL1 interactions 2.504E-4 3.927E-2
3.194E-1
4.790E-1
 2 11
12 int:ZFP36 ZFP36 interactions 2.558E-4 3.927E-2
3.194E-1
4.894E-1
 3 57
13 int:WASF3 WASF3 interactions 3.001E-4 3.927E-2
3.194E-1
5.740E-1
 2 12
14 int:RAP1GDS1 RAP1GDS1 interactions 3.282E-4 3.927E-2
3.194E-1
6.279E-1
 3 62
15 int:WASL WASL interactions 3.605E-4 3.927E-2
3.194E-1
6.897E-1
 3 64
16 int:NEDD4 NEDD4 interactions 3.872E-4 3.927E-2
3.194E-1
7.407E-1
 5 290
17 int:SPRY4 SPRY4 interactions 4.126E-4 3.927E-2
3.194E-1
7.893E-1
 2 14
18 int:TESK1 TESK1 interactions 4.126E-4 3.927E-2
3.194E-1
7.893E-1
 2 14
19 int:RILP RILP interactions 4.126E-4 3.927E-2
3.194E-1
7.893E-1
 2 14
20 int:SHC2 SHC2 interactions 4.126E-4 3.927E-2
3.194E-1
7.893E-1
 2 14
21 int:SH3GL2 SH3GL2 interactions 4.311E-4 3.927E-2
3.194E-1
8.246E-1
 3 68
22 int:LCE2D LCE2D interactions 4.754E-4 4.134E-2
3.363E-1
9.095E-1
 2 15
23 int:ABI2 ABI2 interactions 5.310E-4 4.325E-2
3.518E-1
1.000E0
 3 73
24 int:RTFDC1 RTFDC1 interactions 5.426E-4 4.325E-2
3.518E-1
1.000E0
 2 16
Show 19 more annotations

10: Cytoband [Display Chart] 36 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15q21 15q21 6.061E-5 2.182E-3 9.109E-3 2.182E-3 2 11
2 5q12.1-q13.2 5q12.1-q13.2 1.067E-3 1.281E-2
5.348E-2
 3.843E-2 1 1
3 7q31.1-q31.33 7q31.1-q31.33 1.067E-3 1.281E-2
5.348E-2
 3.843E-2 1 1
4 Xp22.1-p21.3 Xp22.1-p21.3 3.199E-3 2.303E-2
9.616E-2
1.152E-1
 1 3
5 7p12 7p12 3.199E-3 2.303E-2
9.616E-2
1.152E-1
 1 3
6 17q25.2 17q25.2 6.388E-3 3.823E-2
1.596E-1
2.300E-1
 1 6
7 2q34-q35 2q34-q35 7.449E-3 3.823E-2
1.596E-1
2.682E-1
 1 7
8 2p24.3 2p24.3 8.509E-3 3.823E-2
1.596E-1
3.063E-1
 1 8
9 7p12.1 7p12.1 1.063E-2 3.823E-2
1.596E-1
3.825E-1
 1 10
10 7q21-q22 7q21-q22 1.063E-2 3.823E-2
1.596E-1
3.825E-1
 1 10
11 11q22 11q22 1.168E-2 3.823E-2
1.596E-1
4.205E-1
 1 11
12 13q21.1 13q21.1 1.379E-2 4.137E-2
1.727E-1
4.965E-1
 1 13
13 4q28.1 4q28.1 1.695E-2 4.628E-2
1.932E-1
6.101E-1
 1 16
14 10p15.3 10p15.3 1.800E-2 4.628E-2
1.932E-1
6.479E-1
 1 17
15 4p13 4p13 2.219E-2 4.852E-2
2.026E-1
7.987E-1
 1 21
16 13q31.1 13q31.1 2.323E-2 4.852E-2
2.026E-1
8.363E-1
 1 22
17 13q14 13q14 2.427E-2 4.852E-2
2.026E-1
8.738E-1
 1 23
18 13q12 13q12 2.532E-2 4.852E-2
2.026E-1
9.114E-1
 1 24
19 5p13.3 5p13.3 2.636E-2 4.852E-2
2.026E-1
9.489E-1
 1 25
20 3q26.2 3q26.2 2.844E-2 4.852E-2
2.026E-1
1.000E0
 1 27
21 15q22 15q22 3.051E-2 4.852E-2
2.026E-1
1.000E0
 1 29
22 7p21.3 7p21.3 3.051E-2 4.852E-2
2.026E-1
1.000E0
 1 29
23 3q13.33 3q13.33 3.258E-2 4.852E-2
2.026E-1
1.000E0
 1 31
24 15q22.2 15q22.2 3.362E-2 4.852E-2
2.026E-1
1.000E0
 1 32
25 Xq22.3 Xq22.3 3.568E-2 4.852E-2
2.026E-1
1.000E0
 1 34
26 21q22.2 21q22.2 3.671E-2 4.852E-2
2.026E-1
1.000E0
 1 35
27 1q23.2 1q23.2 3.774E-2 4.852E-2
2.026E-1
1.000E0
 1 36
28 5q33.3 5q33.3 3.774E-2 4.852E-2
2.026E-1
1.000E0
 1 36
Show 23 more annotations

11: Transcription Factor Binding Site [Display Chart] 268 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 31 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1117 ESCRT-II genenames.org 3.952E-3 4.753E-2
1.914E-1
1.225E-1
 1 3
2 1096 Erb-b2 receptor tyrosine kinases genenames.org 5.266E-3 4.753E-2
1.914E-1
1.633E-1
 1 4
3 1200 X-linked mental retardation|Glutamate ionotropic receptor AMPA type subunits genenames.org 5.266E-3 4.753E-2
1.914E-1
1.633E-1
 1 4
4 1295 SEC14 family|PRELI domain containing genenames.org 7.890E-3 4.753E-2
1.914E-1
2.446E-1
 1 6
5 1063 SEC14 family|PRELI domain containing genenames.org 7.890E-3 4.753E-2
1.914E-1
2.446E-1
 1 6
6 1208 ATPase Na+/K+ transporting subunits genenames.org 9.199E-3 4.753E-2
1.914E-1
2.852E-1
 1 7
Show 1 more annotation

13: Coexpression [Display Chart] 3378 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2121 Genes correlated with classical type of glioblastoma multiforme tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.896E-7 9.784E-4 8.515E-3 9.784E-4 6 162
2 M2293 Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512]. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.557E-7 1.445E-3 1.258E-2 2.891E-3 7 315
3 M2875 Genes up-regulated in four lineages of epithelial cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v5.1) 4.106E-6 4.624E-3 4.024E-2 1.387E-2 5 143
4 GSE37605 C57BL6 VS NOD FOXP3 FUSION GFP TREG DN Genes down-regulated in Foxp3-Fusion-GFP T reg (FOXP3+ [GeneID=50943]): B6 versus NOD background. MSigDB C7: Immunologic Signatures (v5.1) 1.475E-5 7.915E-3
6.888E-2
 4.981E-2 5 186
5 M1741 Genes whose promoters are bound by FOXP3 [GeneID=50943] based an a ChIP-chip analysis. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.584E-5 7.915E-3
6.888E-2
5.349E-2
 7 491
6 M2726 Genes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] MCF-7 cells (breast cancer) stably over-expressing constitutively active RAF1 [Gene ID=5894] gene. MSigDB C6: Oncogenic Signatures (v5.1) 1.807E-5 7.915E-3
6.888E-2
6.103E-2
 5 194
7 M2698 Genes up-regulated in NCI-60 panel of cell lines with mutated TP53 [Gene ID=7157]. MSigDB C6: Oncogenic Signatures (v5.1) 1.807E-5 7.915E-3
6.888E-2
6.103E-2
 5 194
8 M4558 Genes down-regulated in comparison of DN2 thymocytes versus DN3 thymocytes. MSigDB C7: Immunologic Signatures (v5.1) 2.092E-5 7.915E-3
6.888E-2
7.066E-2
 5 200
9 M259 Genes up-regulated in response to both hypoxia and overexpression of an active form of HIF1A [GeneID=3091]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.467E-5 7.915E-3
6.888E-2
8.335E-2
 5 207
10 M5908 Genes defining response to androgens. MSigDB H: Hallmark Gene Sets (v5.1) 2.518E-5 7.915E-3
6.888E-2
8.507E-2
 4 101
11 M5793 Down-regulated genes in the canonical gene expression signature of the fibroblast core serum response (CSR) defined by the Stanford group. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.584E-5 7.915E-3
6.888E-2
8.728E-2
 5 209
12 M11581 Genes up-regulated in pilocytic astrocytoma compared to glioblastoma samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.812E-5 7.915E-3
6.888E-2
9.498E-2
 3 35
13 M4995 Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.510E-5 1.172E-2
1.020E-1
1.524E-1
 6 390
14 M1796 The glioblastoma multiforme (GBM) plasticity signature: genes up-regulated in neural stem cells (NSC) with double knockout of TP53 and PTEN [GeneID=7157;5728] vs those with knockout of TP53 alone. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.067E-5 1.391E-2
1.211E-1
2.049E-1
 5 250
15 M1320 Genes up-regulated in 10T1/2 cells (multipotent mesoderma) by expression of SHH [GeneID=6469]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.178E-5 1.391E-2
1.211E-1
2.087E-1
 4 127
16 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.303E-5 1.542E-2
1.342E-1
2.467E-1
 5 260
17 M950 Genes up-regulated in A549 cells (lung carcinoma) upon infection with RSV (respiratory syncytial virus) and down-regulated by further treatment with ribavirin [PubChem=5064]. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.781E-5 1.745E-2
1.518E-1
2.966E-1
 3 51
18 M2882 Genes up-regulated in four lineages of epithelial cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v5.1) 1.035E-4 1.790E-2
1.557E-1
3.497E-1
 5 280
19 M14507 Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.044E-4 1.790E-2
1.557E-1
3.525E-1
 6 454
20 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.121E-4 1.790E-2
1.557E-1
3.788E-1
 6 460
21 M2570 Genes up-regulated during prostate cancer progression in the JOCK1 model due to inducible activation of FGFR1 [GeneID=2260] gene in prostate. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.201E-4 1.790E-2
1.557E-1
4.056E-1
 5 289
22 GSE21033 CTRL VS POLYIC STIM DC 24H DN Genes down-regulated in bone marrow-derived dendritic cellstreated by poly(IC): 0h versus 24h. MSigDB C7: Immunologic Signatures (v5.1) 1.209E-4 1.790E-2
1.557E-1
4.082E-1
 4 151
23 M2316 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of both BMI1 and PCGF2 [GeneID=648, 7703] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.225E-4 1.790E-2
1.557E-1
4.139E-1
 3 57
24 M988 Genes up-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.271E-4 1.790E-2
1.557E-1
4.295E-1
 4 153
25 M1973 Genes up-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [GeneID=9589] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.475E-4 1.840E-2
1.601E-1
4.982E-1
 5 302
26 GSE25677 R848 VS MPL AND R848 STIM BCELL DN Genes down-regulated in B lymphocytes immunized with: imiquimod [PubChem=13982876] versus monophosphoryl lipid A and imiquimod [PubChem=13982876]. MSigDB C7: Immunologic Signatures (v5.1) 1.584E-4 1.840E-2
1.601E-1
5.352E-1
 4 162
27 M8519 Genes down-regulated in mARMS (molecular ARMS) compared to the mERMS (molecular ERMS) class of rhabdomyosarcoma tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.474E-4 1.840E-2
1.601E-1
8.357E-1
 4 182
28 GSE37605 FOXP3 FUSION GFP VS IRES GFP TREG C57BL6 UP Genes up-regulated in T reg (FOXP3+ [GeneID=50943]) cells from B6 mice: Foxp3-Fusion-GFP versus Foxp3-ires-GFP. MSigDB C7: Immunologic Signatures (v5.1) 2.474E-4 1.840E-2
1.601E-1
8.357E-1
 4 182
29 M2905 Genes up-regulated in DLD1 cells (colon carcinoma) over-expressing LEF1 [Gene ID=51176]. MSigDB C6: Oncogenic Signatures (v5.1) 3.217E-4 1.840E-2
1.601E-1
1.000E0
 4 195
30 M10660 Genes up-regulated in the uteri of ovariectomized mice 6 h after progesterone [PubChem=5994] injection: HOXA10 [GeneID=3206] knockout vs wild type animals. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.228E-4 1.840E-2
1.601E-1
1.000E0
 3 79
31 M2633 Genes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] and engineered to express ligand-activatable EGFR [Gene ID=1956]. MSigDB C6: Oncogenic Signatures (v5.1) 3.280E-4 1.840E-2
1.601E-1
1.000E0
 4 196
32 M14134 Genes down-regulated in ductal carcinoma vs normal ductal breast cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.408E-4 1.840E-2
1.601E-1
1.000E0
 4 198
33 M5293 Genes up-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from young donors versus those treated with TSST at 72 h. MSigDB C7: Immunologic Signatures (v5.1) 3.474E-4 1.840E-2
1.601E-1
1.000E0
 4 199
34 M5289 Genes up-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from young donors versus those treated with TSST at 40 h. MSigDB C7: Immunologic Signatures (v5.1) 3.474E-4 1.840E-2
1.601E-1
1.000E0
 4 199
35 M3239 Genes up-regulated in comparison of naive B cells versus IgM-memory B cells. MSigDB C7: Immunologic Signatures (v5.1) 3.474E-4 1.840E-2
1.601E-1
1.000E0
 4 199
36 M6652 Genes down-regulated in bone marrow-derived macrophages at 45 min of stimulation by IL6 [GeneID=3469] and LPS: wildtype versus IL10 [GeneID=3486] knockout. MSigDB C7: Immunologic Signatures (v5.1) 3.474E-4 1.840E-2
1.601E-1
1.000E0
 4 199
37 M3499 Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 60 min. MSigDB C7: Immunologic Signatures (v5.1) 3.541E-4 1.840E-2
1.601E-1
1.000E0
 4 200
38 GSE13522 CTRL VS T CRUZI Y STRAIN INF SKIN IFNAR KO DN Genes down-regulated in skin after injection of Trypanosoma cruzi (strain Y): wildtype (129S1) versus IFNAR1 [GeneID=3454] knockout. MSigDB C7: Immunologic Signatures (v5.1) 3.541E-4 1.840E-2
1.601E-1
1.000E0
 4 200
39 M3853 Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 1 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 1 h. MSigDB C7: Immunologic Signatures (v5.1) 3.541E-4 1.840E-2
1.601E-1
1.000E0
 4 200
40 GSE43863 DAY6 EFF VS DAY150 MEM LY6C INT CXCR5POS CD4 TCELL UP Genes up-regulated in Ly6c int CXCR5+ CD4 [GeneID=643;920] T cells: effector during acute infection of LCMV versus memory. MSigDB C7: Immunologic Signatures (v5.1) 3.541E-4 1.840E-2
1.601E-1
1.000E0
 4 200
41 GSE21546 WT VS SAP1A KO AND ELK1 KO DP THYMOCYTES DN Genes down-regulated in untreated double positive thymocytes: wildtype versus ELK1 and ELK4 [GeneID=2002;2005] knockout. MSigDB C7: Immunologic Signatures (v5.1) 3.541E-4 1.840E-2
1.601E-1
1.000E0
 4 200
42 M3989 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 2 h. MSigDB C7: Immunologic Signatures (v5.1) 3.541E-4 1.840E-2
1.601E-1
1.000E0
 4 200
43 GSE26890 CXCR1 NEG VS POS EFFECTOR CD8 TCELL UP Genes up-regulated in effector CD8 T cells: CXCR1+ [GeneID=3577] versus CXCR1- [GeneID=3577]. MSigDB C7: Immunologic Signatures (v5.1) 3.541E-4 1.840E-2
1.601E-1
1.000E0
 4 200
44 M5302 Genes up-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from old donors versus those treated with TSST at 72 h. MSigDB C7: Immunologic Signatures (v5.1) 3.541E-4 1.840E-2
1.601E-1
1.000E0
 4 200
45 M4554 Genes down-regulated in comparison of thymic progenitors versus DN3 thymocytes. MSigDB C7: Immunologic Signatures (v5.1) 3.541E-4 1.840E-2
1.601E-1
1.000E0
 4 200
46 M4564 Genes down-regulated in comparison of adult thymic progenitors versus adult DN3 thymocytes. MSigDB C7: Immunologic Signatures (v5.1) 3.541E-4 1.840E-2
1.601E-1
1.000E0
 4 200
47 GSE39556 UNTREATED VS 3H POLYIC INJ MOUSE CD8A DC UP Genes up-regulated in CD8A [GeneID=935] dendritic cells: untreated versus poly(IC). MSigDB C7: Immunologic Signatures (v5.1) 3.541E-4 1.840E-2
1.601E-1
1.000E0
 4 200
48 GSE18203 CTRL VS INTRATUMORAL CPG INJ MC38 TUMOR DN Genes down-regulated in tumors established by injecting MC38 cells (colon cancer): control versus CpG oligodeoxynucleotide 1826. MSigDB C7: Immunologic Signatures (v5.1) 3.541E-4 1.840E-2
1.601E-1
1.000E0
 4 200
49 M5446 Genes up-regulated in comparison of mast cells versus central memory CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v5.1) 3.541E-4 1.840E-2
1.601E-1
1.000E0
 4 200
50 GSE40274 FOXP3 VS FOXP3 AND EOS TRANSDUCED ACTIVATED CD4 TCELL UP Genes up-regulated in CD4 T conv over-expressing: FOXP3 [GeneID=50943] versus IKZF4 and FOXP3 [GeneID=64375;50943]. MSigDB C7: Immunologic Signatures (v5.1) 3.541E-4 1.840E-2
1.601E-1
1.000E0
 4 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 1483 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 OPC Top 500 All OPC Top 500 All Brain Map - Barres 9.738E-17 1.444E-13 1.138E-12 1.444E-13 16 494
2 OPC Top 500 Cluster 3 OPC Top 500 Cluster 3 Brain Map - Barres 2.041E-11 1.514E-8 1.193E-7 3.027E-8 8 111
3 OPC Top 500 Cluster 1 OPC Top 500 Cluster 1 Brain Map - Barres 7.987E-7 3.948E-4 3.111E-3 1.184E-3 4 40
4 endothelial Top 500 Cluster 2 endothelial Top 500 Cluster 2 Brain Map - Barres 6.863E-6 2.545E-3 2.005E-2 1.018E-2 4 68
5 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma k4 1000 dev gonad e13.5 F VascAssocMesenchStromOvary Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.259E-5 3.260E-3 2.569E-2 1.867E-2 5 168
6 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 1.319E-5 3.260E-3 2.569E-2 1.956E-2 7 445
7 80Dn Top 500 Cluster 0 80Dn Top 500 Cluster 0 Brain Map - Allen iN 6.903E-5 1.386E-2
1.092E-1
1.024E-1
 3 44
8 Lungmap Mouse e16.5 Pericyte Top 500 All Mouse Lung E16.5 Pericyte top 500 Lungmap Mouse Single Cell (Lungmap.net) 8.285E-5 1.386E-2
1.092E-1
1.229E-1
 6 406
9 gudmap developingKidney e13.5 podocyte cells 1000 k3 DevelopingKidney e13.5 podocyte cells emap-27773 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 8.414E-5 1.386E-2
1.092E-1
1.248E-1
 5 250
10 OPC Top 500 Cluster 4 OPC Top 500 Cluster 4 Brain Map - Barres 9.543E-5 1.415E-2
1.115E-1
1.415E-1
 3 49
11 PCBC ratio MESO-5 amniotic fluid MSC vs MESO-5 blastocyst cfr-2X-p05 MESO-5 amniotic fluid MSC vs MESO-5 blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.051E-4 1.417E-2
1.117E-1
1.559E-1
 6 424
12 26Dn Top 500 Cluster 2 26Dn Top 500 Cluster 2 Brain Map - Allen iN 1.177E-4 1.454E-2
1.146E-1
1.745E-1
 4 140
13 26Dn SubClass 26Dn 2 Top 500 Cluster 0 26Dn SubClass 26Dn 2 Top 500 Cluster 0 Brain Map - Allen iN 1.535E-4 1.751E-2
1.380E-1
2.277E-1
 4 150
14 gudmap dev gonad e12.5 M InterstitLeydig MafB k1 1000 dev gonad e12.5 M InterstitLeydig MafB k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.332E-4 2.409E-2
1.898E-1
3.459E-1
 5 311
15 12Dn Top 500 All 12Dn Top 500 All Brain Map - Allen iN 2.437E-4 2.409E-2
1.898E-1
3.614E-1
 6 495
16 endothelial SubClass DCN-hi Top 500 Cluster 4 endothelial SubClass DCN-hi Top 500 Cluster 4 Brain Map - Barres 3.775E-4 3.093E-2
2.437E-1
5.598E-1
 2 16
17 gudmap dev gonad e12.5 M InterstitTestis Sma k4 1000 dev gonad e12.5 M InterstitTestis Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.861E-4 3.093E-2
2.437E-1
5.726E-1
 4 191
18 gudmap kidney adult Mesangium Meis k2 1000 kidney adult Mesangium Meis k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.911E-4 3.093E-2
2.437E-1
5.800E-1
 5 348
19 GSM476675 500 gamma delta T cells, Tgd.Th, TCRd+ CD3e+, Thymus, avg-3 Immgen.org, GSE15907 3.963E-4 3.093E-2
2.437E-1
5.876E-1
 5 349
20 GSM605773 500 alpha beta T cells, T.8.TI.B16, 4- 8+ TCR+ 45+, B16 Melanoma Tumor, avg-2 Immgen.org, GSE15907 4.508E-4 3.343E-2
2.634E-1
6.685E-1
 5 359
21 54Dn Top 500 Cluster 2 54Dn Top 500 Cluster 2 Brain Map - Allen iN 5.360E-4 3.660E-2
2.884E-1
7.949E-1
 2 19
22 gudmap dev gonad e12.5 M InterstitTestis Sma 500 dev gonad e12.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 5.430E-4 3.660E-2
2.884E-1
8.053E-1
 5 374
23 Facebase RNAseq e9.5 Maxillary Arch 500 K5 FacebaseRNAseq e9.5 Maxillary Arch top-relative-expression-ranked 500 k-means-cluster#5 FaceBase_RNAseq 6.165E-4 3.975E-2
3.132E-1
9.142E-1
 3 92
24 gudmap dev gonad e13.5 M InterstitTestis Sma k4 200 dev gonad e13.5 M InterstitTestis Sma k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 7.216E-4 4.459E-2
3.514E-1
1.000E0
 2 22
25 GSM605793 500 gamma delta T cells, Tgd.vg2+24ahi.Th.TCRbko, TCRd+ Vg2+ CD24+, Thymus, avg-3 Immgen.org, GSE15907 8.401E-4 4.954E-2
3.903E-1
1.000E0
 5 412
26 Lungmap Mouse e18.5 Epithelial (GSE52583) SubClass AT1 Top 500 All Mouse Lung E18.5 Epithelial AT1 top 500 Lungmap Mouse Single Cell (Lungmap.net) 8.963E-4 4.954E-2
3.903E-1
1.000E0
 5 418
27 Lungmap Mouse e16.5 Myofibro Top 500 All Lungmap Mouse e16.5 Myofibro Top 500 All Lungmap Mouse Single Cell (Lungmap.net) 9.157E-4 4.954E-2
3.903E-1
1.000E0
 5 420
28 GSM476658 500 gamma delta T cells, Tgd.vg2-24ahi.Th, TCRd+ Vg2- CD24+, Thymus, avg-2 Immgen.org, GSE15907 9.353E-4 4.954E-2
3.903E-1
1.000E0
 5 422
Show 23 more annotations

15: Computational [Display Chart] 158 annotations before applied cutoff / 9399 genes in category

No results to display

16: MicroRNA [Display Chart] 859 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 TACTTGA,MIR-26B:MSigDB TACTTGA,MIR-26B:MSigDB MSigDB 1.279E-5 3.981E-3 2.919E-2 1.099E-2 6 283
2 TACTTGA,MIR-26A:MSigDB TACTTGA,MIR-26A:MSigDB MSigDB 1.279E-5 3.981E-3 2.919E-2 1.099E-2 6 283
3 hsa-miR-26a:PITA hsa-miR-26a:PITA TOP PITA 2.317E-5 3.981E-3 2.919E-2 1.990E-2 7 473
4 hsa-miR-26b:PITA hsa-miR-26b:PITA TOP PITA 2.317E-5 3.981E-3 2.919E-2 1.990E-2 7 473
5 hsa-miR-1297:PITA hsa-miR-1297:PITA TOP PITA 2.317E-5 3.981E-3 2.919E-2 1.990E-2 7 473
6 hsa-miR-590-5p:TargetScan hsa-miR-590-5p:TargetScan TargetScan 4.093E-5 5.023E-3 3.683E-2 3.516E-2 5 209
7 hsa-miR-21:TargetScan hsa-miR-21:TargetScan TargetScan 4.093E-5 5.023E-3 3.683E-2 3.516E-2 5 209
8 hsa-miR-371-5p:PITA hsa-miR-371-5p:PITA TOP PITA 8.364E-5 8.981E-3
6.586E-2
7.185E-2
 5 243
9 hsa-miR-924:PITA hsa-miR-924:PITA TOP PITA 1.538E-4 1.468E-2
1.076E-1
1.321E-1
 4 146
10 hsa-miR-512-5p:PITA hsa-miR-512-5p:PITA TOP PITA 1.795E-4 1.542E-2
1.131E-1
1.542E-1
 4 152
11 TGGTGCT,MIR-29A:MSigDB TGGTGCT,MIR-29A:MSigDB MSigDB 2.387E-4 1.577E-2
1.157E-1
2.051E-1
 6 480
12 TGGTGCT,MIR-29C:MSigDB TGGTGCT,MIR-29C:MSigDB MSigDB 2.387E-4 1.577E-2
1.157E-1
2.051E-1
 6 480
13 TGGTGCT,MIR-29B:MSigDB TGGTGCT,MIR-29B:MSigDB MSigDB 2.387E-4 1.577E-2
1.157E-1
2.051E-1
 6 480
14 hsa-miR-18a:TargetScan hsa-miR-18a:TargetScan TargetScan 4.117E-4 2.255E-2
1.654E-1
3.537E-1
 4 189
15 hsa-miR-18b:TargetScan hsa-miR-18b:TargetScan TargetScan 4.117E-4 2.255E-2
1.654E-1
3.537E-1
 4 189
16 hsa-miR-219-2-3p:PITA hsa-miR-219-2-3p:PITA TOP PITA 4.200E-4 2.255E-2
1.654E-1
3.608E-1
 4 190
17 hsa-miR-1200:PITA hsa-miR-1200:PITA TOP PITA 4.547E-4 2.297E-2
1.685E-1
3.906E-1
 5 350
18 hsa-miR-371-5p:TargetScan hsa-miR-371-5p:TargetScan TargetScan 5.001E-4 2.307E-2
1.692E-1
4.296E-1
 4 199
19 hsa-miR-768-3p:PITA hsa-miR-768-3p:PITA TOP PITA 5.104E-4 2.307E-2
1.692E-1
4.384E-1
 5 359
20 hsa-miR-27a:miRTarbase hsa-miR-27a:miRTarbase miRTarbase 5.670E-4 2.435E-2
1.786E-1
4.871E-1
 2 19
21 hsa-miR-516a-3p:PITA hsa-miR-516a-3p:PITA TOP PITA 6.344E-4 2.595E-2
1.903E-1
5.449E-1
 4 212
22 hsa-miR-603:PITA hsa-miR-603:PITA TOP PITA 7.004E-4 2.735E-2
2.006E-1
6.016E-1
 5 385
23 hsa-miR-892b:PITA hsa-miR-892b:PITA TOP PITA 7.537E-4 2.815E-2
2.064E-1
6.474E-1
 4 222
24 hsa-miR-188-3p:PITA hsa-miR-188-3p:PITA TOP PITA 8.325E-4 2.980E-2
2.185E-1
7.151E-1
 4 228
25 miR-320:PicTar miR-320:PicTar PicTar 8.990E-4 3.089E-2
2.265E-1
7.723E-1
 5 407
26 CAGCTTT,MIR-320:MSigDB CAGCTTT,MIR-320:MSigDB MSigDB 1.007E-3 3.328E-2
2.441E-1
8.653E-1
 4 240
27 ATAAGCT,MIR-21:MSigDB ATAAGCT,MIR-21:MSigDB MSigDB 1.308E-3 3.913E-2
2.869E-1
1.000E0
 3 116
28 ACTGTGA,MIR-27B:MSigDB ACTGTGA,MIR-27B:MSigDB MSigDB 1.364E-3 3.913E-2
2.869E-1
1.000E0
 5 447
29 ACTGTGA,MIR-27A:MSigDB ACTGTGA,MIR-27A:MSigDB MSigDB 1.364E-3 3.913E-2
2.869E-1
1.000E0
 5 447
30 hsa-miR-590-5p:PITA hsa-miR-590-5p:PITA TOP PITA 1.373E-3 3.913E-2
2.869E-1
1.000E0
 4 261
31 hsa-miR-21:PITA hsa-miR-21:PITA TOP PITA 1.412E-3 3.913E-2
2.869E-1
1.000E0
 4 263
32 hsa-miR-298:PITA hsa-miR-298:PITA TOP PITA 1.534E-3 3.982E-2
2.920E-1
1.000E0
 4 269
33 hsa-miR-421:TargetScan hsa-miR-421:TargetScan TargetScan 1.576E-3 3.982E-2
2.920E-1
1.000E0
 4 271
34 miR-22:PicTar miR-22:PicTar PicTar 1.576E-3 3.982E-2
2.920E-1
1.000E0
 4 271
35 hsa-miR-4308:mirSVR highEffct hsa-miR-4308:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.849E-3 4.008E-2
2.939E-1
1.000E0
 5 479
36 hsa-miR-422a:PITA hsa-miR-422a:PITA TOP PITA 1.854E-3 4.008E-2
2.939E-1
1.000E0
 3 131
37 hsa-miR-378:PITA hsa-miR-378:PITA TOP PITA 1.854E-3 4.008E-2
2.939E-1
1.000E0
 3 131
38 hsa-miR-1297:miRTarbase hsa-miR-1297:miRTarbase miRTarbase 1.865E-3 4.008E-2
2.939E-1
1.000E0
 1 1
39 hsa-miR-511:miRTarbase hsa-miR-511:miRTarbase miRTarbase 1.865E-3 4.008E-2
2.939E-1
1.000E0
 1 1
40 hsa-miR-597:mirSVR highEffct hsa-miR-597:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.866E-3 4.008E-2
2.939E-1
1.000E0
 5 480
41 hsa-miR-641:PITA hsa-miR-641:PITA TOP PITA 2.042E-3 4.279E-2
3.138E-1
1.000E0
 5 490
42 hsa-miR-1911:mirSVR highEffct hsa-miR-1911:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.121E-3 4.339E-2
3.182E-1
1.000E0
 4 294
43 TCCAGAG,MIR-518C:MSigDB TCCAGAG,MIR-518C:MSigDB MSigDB 2.380E-3 4.754E-2
3.486E-1
1.000E0
 3 143
44 miR-21:PicTar miR-21:PicTar PicTar 2.524E-3 4.927E-2
3.614E-1
1.000E0
 3 146
Show 39 more annotations

17: Drug [Display Chart] 7930 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7422 UP Nortriptyline hydrochloride [894-71-3]; Up 200; 13.4uM; MCF7; HT HG-U133A Broad Institute CMAP 6.374E-7 5.054E-3 4.830E-2 5.054E-3 6 182
2 D015073 2-Acetylaminofluorene CTD 4.935E-6 1.353E-2
1.292E-1
 3.913E-2 7 403
3 C430898 AGN 194204 CTD 5.117E-6 1.353E-2
1.292E-1
 4.058E-2 5 147
4 CID000003112 AC1L1F75 Stitch 1.662E-5 3.295E-2
3.149E-1
1.318E-1
 3 29
5 5696 UP Androsterone [53-41-8]; Up 200; 13.8uM; MCF7; HT HG-U133A Broad Institute CMAP 2.220E-5 3.521E-2
3.365E-1
1.761E-1
 5 199
6 CID000093177 3-quinolinecarbonitrile Stitch 2.870E-5 3.793E-2
3.625E-1
2.276E-1
 2 5
Show 1 more annotation

18: Disease [Display Chart] 1088 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0854917 Rhabdoid Tumor of the Kidney DisGeNET BeFree 6.733E-5 3.998E-2
3.026E-1
7.326E-2
 4 105
2 umls:C0010278 Craniosynostosis DisGeNET Curated 1.206E-4 3.998E-2
3.026E-1
1.312E-1
 4 122
3 umls:C0039075 Syndactyly DisGeNET Curated 1.382E-4 3.998E-2
3.026E-1
1.504E-1
 3 48
4 umls:C0334579 Anaplastic astrocytoma DisGeNET Curated 1.886E-4 3.998E-2
3.026E-1
2.052E-1
 4 137
5 umls:C0280317 Squamous cell carcinoma of tonsil DisGeNET BeFree 1.916E-4 3.998E-2
3.026E-1
2.084E-1
 2 10
6 umls:C0024668 Mammary Neoplasms, Experimental DisGeNET Curated 2.808E-4 3.998E-2
3.026E-1
3.055E-1
 4 152
7 umls:C0032962 Pregnancy Complications DisGeNET Curated 3.105E-4 3.998E-2
3.026E-1
3.379E-1
 3 63
8 umls:C0947912 Myasthenias DisGeNET BeFree 3.307E-4 3.998E-2
3.026E-1
3.598E-1
 2 13
9 umls:C0016978 gallbladder neoplasm DisGeNET Curated 3.307E-4 3.998E-2
3.026E-1
3.598E-1
 2 13
10 umls:C1368354 Mixed Neoplasm DisGeNET BeFree 3.853E-4 4.192E-2
3.174E-1
4.192E-1
 2 14
11 umls:C0206655 Alveolar rhabdomyosarcoma DisGeNET Curated 5.396E-4 4.393E-2
3.326E-1
5.871E-1
 3 76
12 umls:C0036631 Seminoma DisGeNET Curated 8.995E-4 4.393E-2
3.326E-1
9.787E-1
 4 207
13 umls:C0220636 Malignant neoplasm of salivary gland DisGeNET BeFree 1.059E-3 4.393E-2
3.326E-1
1.000E0
 2 23
14 umls:C0566602 Primary sclerosing cholangitis DisGeNET Curated 1.497E-3 4.393E-2
3.326E-1
1.000E0
 3 108
15 umls:C0278493 Breast cancer recurrent DisGeNET BeFree 1.571E-3 4.393E-2
3.326E-1
1.000E0
 2 28
16 umls:C1269683 Major Depressive Disorder DisGeNET Curated 2.044E-3 4.393E-2
3.326E-1
1.000E0
 5 436
17 umls:C0278583 Cervical carcinoma stage IIB DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
18 umls:C4015130 INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL, 2 DisGeNET Curated 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
19 umls:C3163943 Combined large cell neuroendocrine carcinoma DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
20 umls:C0334240 Combined small cell carcinoma DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
21 umls:C1367859 Pineal parenchymal tumor of intermediate differentiation DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
22 umls:C0748164 Multiple Pulmonary Nodules DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
23 umls:C1275155 Multiple basal cell papillomata DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
24 cv:C1859309 Syndactyly Cenani Lenz type Clinical Variations 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
25 cv:C3280402 Sclerosteosis 2 Clinical Variations 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
26 602481 MIGRAINE, FAMILIAL HEMIPLEGIC, 2; FHM2 OMIM 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
27 umls:C0280325 Glottis Squamous Cell Carcinoma DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
28 umls:C0278846 Thymoma malignant invasive DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
29 umls:C0581882 Transient neurological symptoms DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
30 umls:C0862802 Recurrent lung cancer DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
31 umls:C3151064 46,XY SEX REVERSAL 6 DisGeNET Curated 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
32 umls:C1319018 Asthmatic bronchitis DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
33 umls:C0270816 epilepsy and migraine DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
34 cv:CN220919 Microcephaly 12, primary, autosomal recessive Clinical Variations 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
35 cv:CN220784 Inflammatory skin and bowel disease, neonatal, 2 Clinical Variations 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
36 umls:C1865323 Migraine, Familial Basilar DisGeNET Curated 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
37 umls:C3549447 ALTERNATING HEMIPLEGIA OF CHILDHOOD 1 DisGeNET Curated 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
38 umls:C0334268 Schneiderian papilloma DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
39 umls:C1711276 carcinosarcoma of lung DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
40 umls:C1336536 Supratentorial Glioblastoma DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
41 umls:C3715051 CRANIOSYNOSTOSIS 3 DisGeNET Curated 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
42 umls:C4015156 MICROCEPHALY 12, PRIMARY, AUTOSOMAL RECESSIVE DisGeNET Curated 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
43 umls:C0854983 Lung adenocarcinoma recurrent DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
44 umls:C1279945 Acute interstitial pneumonia DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
45 cv:CN177972 Craniosynostosis 3 Clinical Variations 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
46 umls:C0279557 Adenosquamous cell lung cancer DisGeNET BeFree 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
47 cv:C0338488 Alternating hemiplegia of childhood Clinical Variations 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
48 cv:C3151064 46,XY sex reversal, type 6 Clinical Variations 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
49 cv:CN229746 MYASTHENIC SYNDROME, CONGENITAL, 17 Clinical Variations 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
50 cv:C1865322 Familial hemiplegic migraine type 2 Clinical Variations 2.105E-3 4.393E-2
3.326E-1
1.000E0
 1 1
Show 45 more annotations