Toppgene analysis for aggregated_1964_log, IC21, positive side

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1: GO: Molecular Function [Display Chart] 646 annotations before applied cutoff / 18819 genes in category

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2: GO: Biological Process [Display Chart] 3224 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008366 axon ensheathment 5.029E-12 8.108E-9 7.018E-8 1.622E-8 15 124
2 GO:0007272 ensheathment of neurons 5.029E-12 8.108E-9 7.018E-8 1.622E-8 15 124
3 GO:0042552 myelination 5.431E-11 5.837E-8 5.052E-7 1.751E-7 14 122
4 GO:0010038 response to metal ion 1.009E-7 8.135E-5 7.042E-4 3.254E-4 18 368
5 GO:0010975 regulation of neuron projection development 1.724E-6 1.112E-3 9.624E-3 5.559E-3 19 494
6 GO:0006665 sphingolipid metabolic process 5.901E-6 2.718E-3 2.352E-2 1.902E-2 10 152
7 GO:0010977 negative regulation of neuron projection development 5.901E-6 2.718E-3 2.352E-2 1.902E-2 10 152
8 GO:0048709 oligodendrocyte differentiation 8.497E-6 3.424E-3 2.964E-2 2.740E-2 8 95
9 GO:0042063 gliogenesis 1.205E-5 4.316E-3 3.736E-2 3.885E-2 13 282
10 GO:0050768 negative regulation of neurogenesis 1.452E-5 4.681E-3 4.052E-2 4.681E-2 13 287
11 GO:0002576 platelet degranulation 2.041E-5 5.983E-3
5.179E-2
6.582E-2
 8 107
12 GO:0099612 protein localization to axon 2.393E-5 6.120E-3
5.298E-2
7.713E-2
 3 6
13 GO:0031345 negative regulation of cell projection organization 2.468E-5 6.120E-3
5.298E-2
7.956E-2
 10 179
14 GO:0051961 negative regulation of nervous system development 3.366E-5 7.440E-3
6.440E-2
1.085E-1
 13 311
15 GO:0050804 modulation of synaptic transmission 3.486E-5 7.440E-3
6.440E-2
1.124E-1
 14 358
16 GO:0045665 negative regulation of neuron differentiation 3.775E-5 7.440E-3
6.440E-2
1.217E-1
 11 228
17 GO:0006672 ceramide metabolic process 3.926E-5 7.440E-3
6.440E-2
1.266E-1
 7 86
18 GO:0030913 paranodal junction assembly 4.154E-5 7.440E-3
6.440E-2
1.339E-1
 3 7
19 GO:0021782 glial cell development 4.900E-5 8.296E-3
7.181E-2
1.580E-1
 7 89
20 GO:0014003 oligodendrocyte development 5.147E-5 8.296E-3
7.181E-2
1.659E-1
 5 38
21 GO:0032288 myelin assembly 5.494E-5 8.435E-3
7.301E-2
1.771E-1
 4 20
22 GO:0006643 membrane lipid metabolic process 6.069E-5 8.895E-3
7.699E-2
1.957E-1
 10 199
23 GO:0010001 glial cell differentiation 1.068E-4 1.498E-2
1.296E-1
3.445E-1
 10 213
24 GO:0031331 positive regulation of cellular catabolic process 1.182E-4 1.588E-2
1.374E-1
3.811E-1
 13 352
25 GO:0010721 negative regulation of cell development 1.322E-4 1.660E-2
1.437E-1
4.262E-1
 13 356
26 GO:0006687 glycosphingolipid metabolic process 1.342E-4 1.660E-2
1.437E-1
4.328E-1
 6 73
27 GO:0045837 negative regulation of membrane potential 1.391E-4 1.660E-2
1.437E-1
4.483E-1
 3 10
28 GO:0021762 substantia nigra development 1.454E-4 1.674E-2
1.449E-1
4.688E-1
 5 47
29 GO:0010508 positive regulation of autophagy 2.549E-4 2.758E-2
2.387E-1
8.218E-1
 6 82
30 GO:0048871 multicellular organismal homeostasis 2.566E-4 2.758E-2
2.387E-1
8.273E-1
 13 381
31 GO:1990267 response to transition metal nanoparticle 3.162E-4 3.289E-2
2.847E-1
1.000E0
 8 158
32 GO:0046513 ceramide biosynthetic process 3.349E-4 3.349E-2
2.898E-1
1.000E0
 5 56
33 GO:0035694 mitochondrial protein catabolic process 3.427E-4 3.349E-2
2.898E-1
1.000E0
 2 3
34 GO:0042982 amyloid precursor protein metabolic process 4.160E-4 3.944E-2
3.414E-1
1.000E0
 4 33
35 GO:0007584 response to nutrient 4.459E-4 4.012E-2
3.473E-1
1.000E0
 9 209
36 GO:0050830 defense response to Gram-positive bacterium 4.480E-4 4.012E-2
3.473E-1
1.000E0
 6 91
37 GO:0022010 central nervous system myelination 5.067E-4 4.299E-2
3.721E-1
1.000E0
 3 15
38 GO:0032291 axon ensheathment in central nervous system 5.067E-4 4.299E-2
3.721E-1
1.000E0
 3 15
39 GO:0009896 positive regulation of catabolic process 5.644E-4 4.666E-2
4.039E-1
1.000E0
 13 414
40 GO:0007220 Notch receptor processing 6.187E-4 4.876E-2
4.221E-1
1.000E0
 3 16
41 GO:0045055 regulated exocytosis 6.471E-4 4.876E-2
4.221E-1
1.000E0
 11 316
42 GO:0034405 response to fluid shear stress 6.492E-4 4.876E-2
4.221E-1
1.000E0
 4 37
43 GO:0071205 protein localization to juxtaparanode region of axon 6.806E-4 4.876E-2
4.221E-1
1.000E0
 2 4
44 GO:0002175 protein localization to paranode region of axon 6.806E-4 4.876E-2
4.221E-1
1.000E0
 2 4
45 GO:0097460 ferrous iron import into cell 6.806E-4 4.876E-2
4.221E-1
1.000E0
 2 4
Show 40 more annotations

3: GO: Cellular Component [Display Chart] 360 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043209 myelin sheath 6.186E-11 2.227E-8 1.440E-7 2.227E-8 17 204
2 GO:0005775 vacuolar lumen 4.019E-6 5.141E-4 3.324E-3 1.447E-3 9 116
3 GO:0043202 lysosomal lumen 4.284E-6 5.141E-4 3.324E-3 1.542E-3 8 88
4 GO:0033010 paranodal junction 1.152E-5 9.565E-4 6.184E-3 4.146E-3 3 5
5 GO:0044304 main axon 1.329E-5 9.565E-4 6.184E-3 4.783E-3 7 74
6 GO:0043218 compact myelin 4.176E-5 1.934E-3 1.250E-2 1.503E-2 4 19
7 GO:0098852 lytic vacuole membrane 4.297E-5 1.934E-3 1.250E-2 1.547E-2 12 278
8 GO:0005765 lysosomal membrane 4.297E-5 1.934E-3 1.250E-2 1.547E-2 12 278
9 GO:0031092 platelet alpha granule membrane 3.093E-4 1.237E-2
7.999E-2
1.114E-1
 3 13
10 GO:0030667 secretory granule membrane 3.666E-4 1.320E-2
8.531E-2
1.320E-1
 6 89
11 GO:0033270 paranode region of axon 4.845E-4 1.586E-2
1.025E-1
1.744E-1
 3 15
12 GO:0033268 node of Ranvier 5.917E-4 1.775E-2
1.147E-1
2.130E-1
 3 16
13 GO:0005770 late endosome 6.584E-4 1.823E-2
1.179E-1
2.370E-1
 9 224
14 GO:0030426 growth cone 7.312E-4 1.880E-2
1.215E-1
2.632E-1
 8 182
15 GO:0097386 glial cell projection 8.488E-4 1.962E-2
1.269E-1
3.056E-1
 3 18
16 GO:0030427 site of polarized growth 8.722E-4 1.962E-2
1.269E-1
3.140E-1
 8 187
17 GO:0014069 postsynaptic density 1.011E-3 1.996E-2
1.290E-1
3.640E-1
 9 238
18 GO:0099572 postsynaptic specialization 1.011E-3 1.996E-2
1.290E-1
3.640E-1
 9 238
19 GO:0097418 neurofibrillary tangle 1.092E-3 1.996E-2
1.290E-1
3.933E-1
 2 5
20 GO:0005635 nuclear envelope 1.143E-3 1.996E-2
1.290E-1
4.116E-1
 13 454
21 GO:0010008 endosome membrane 1.164E-3 1.996E-2
1.290E-1
4.191E-1
 12 399
22 GO:0020005 symbiont-containing vacuole membrane 1.627E-3 2.663E-2
1.721E-1
5.858E-1
 2 6
23 GO:0060076 excitatory synapse 1.767E-3 2.765E-2
1.788E-1
6.360E-1
 9 258
24 GO:0020003 symbiont-containing vacuole 2.262E-3 3.384E-2
2.187E-1
8.144E-1
 2 7
25 GO:0044440 endosomal part 2.350E-3 3.384E-2
2.187E-1
8.459E-1
 12 434
26 GO:0005902 microvillus 2.821E-3 3.906E-2
2.525E-1
1.000E0
 5 91
27 GO:1990712 HFE-transferrin receptor complex 2.995E-3 3.994E-2
2.582E-1
1.000E0
 2 8
28 GO:0072687 meiotic spindle 3.824E-3 4.302E-2
2.781E-1
1.000E0
 2 9
29 GO:0032045 guanyl-nucleotide exchange factor complex 3.824E-3 4.302E-2
2.781E-1
1.000E0
 2 9
30 GO:0035748 myelin sheath abaxonal region 3.824E-3 4.302E-2
2.781E-1
1.000E0
 2 9
31 GO:0042583 chromaffin granule 3.824E-3 4.302E-2
2.781E-1
1.000E0
 2 9
32 GO:0065010 extracellular membrane-bounded organelle 3.824E-3 4.302E-2
2.781E-1
1.000E0
 2 9
33 GO:0031594 neuromuscular junction 3.976E-3 4.338E-2
2.804E-1
1.000E0
 4 61
34 GO:0044224 juxtaparanode region of axon 4.747E-3 4.747E-2
3.069E-1
1.000E0
 2 10
35 GO:0033655 host cell cytoplasm part 4.747E-3 4.747E-2
3.069E-1
1.000E0
 2 10
36 GO:0030430 host cell cytoplasm 4.747E-3 4.747E-2
3.069E-1
1.000E0
 2 10
Show 31 more annotations

4: Human Phenotype [Display Chart] 741 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0030223 Perseveration 4.597E-7 3.407E-4 2.448E-3 3.407E-4 4 7
2 HP:0000741 Apathy 3.141E-6 1.164E-3 8.364E-3 2.328E-3 5 22
3 HP:0001336 Myoclonus 9.496E-6 2.345E-3 1.685E-2 7.036E-3 8 98
4 HP:0000710 Hyperorality 1.270E-5 2.352E-3 1.690E-2 9.408E-3 3 5
5 HP:0002015 Dysphagia 7.190E-5 1.066E-2
7.657E-2
5.328E-2
 9 167
6 HP:0002529 Neuronal loss in central nervous system 1.078E-4 1.120E-2
8.051E-2
7.989E-2
 5 44
7 HP:0030213 Emotional blunting 1.210E-4 1.120E-2
8.051E-2
8.963E-2
 2 2
8 HP:0008768 Inappropriate sexual behavior {has synonym type="layperson"} 1.210E-4 1.120E-2
8.051E-2
8.963E-2
 2 2
9 HP:0002185 Neurofibrillary tangles 1.434E-4 1.181E-2
8.483E-2
1.063E-1
 4 25
10 HP:0002145 Frontotemporal dementia 3.410E-4 2.151E-2
1.546E-1
2.527E-1
 3 13
11 HP:0000734 Disinhibition {has synonym type="layperson"} 3.410E-4 2.151E-2
1.546E-1
2.527E-1
 3 13
12 HP:0040154 Acne inversa 3.603E-4 2.151E-2
1.546E-1
2.670E-1
 2 3
13 HP:0000726 Dementia {has synonym type="layperson"} 3.774E-4 2.151E-2
1.546E-1
2.796E-1
 7 124
14 HP:0000737 Irritability {has synonym type="layperson"} 4.745E-4 2.512E-2
1.805E-1
3.516E-1
 5 60
15 HP:0000748 Inappropriate laughter {has synonym type="layperson"} 7.155E-4 3.485E-2
2.504E-1
5.302E-1
 2 4
16 HP:0000751 Personality changes {has synonym type="layperson"} 7.524E-4 3.485E-2
2.504E-1
5.575E-1
 4 38
17 HP:0003678 Rapidly progressive 8.316E-4 3.625E-2
2.605E-1
6.162E-1
 4 39
18 HP:0001153 Septate vagina 1.184E-3 4.068E-2
2.923E-1
8.774E-1
 2 5
19 HP:0004333 Bone-marrow foam cells 1.184E-3 4.068E-2
2.923E-1
8.774E-1
 2 5
20 HP:0002361 Psychomotor deterioration 1.184E-3 4.068E-2
2.923E-1
8.774E-1
 2 5
21 HP:0004975 Erlenmeyer flask deformity of the femurs 1.184E-3 4.068E-2
2.923E-1
8.774E-1
 2 5
22 HP:0002591 Polyphagia 1.208E-3 4.068E-2
2.923E-1
8.949E-1
 4 43
23 HP:0002313 Spastic paraparesis 1.287E-3 4.146E-2
2.979E-1
9.536E-1
 3 20
Show 18 more annotations

5: Mouse Phenotype [Display Chart] 2505 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0003871 abnormal myelin sheath morphology 2.823E-8 7.071E-5 5.942E-4 7.071E-5 11 80
2 MP:0005404 abnormal axon morphology 1.432E-7 1.794E-4 1.508E-3 3.588E-4 16 215
3 MP:0000920 abnormal myelination 1.675E-6 1.398E-3 1.175E-2 4.195E-3 14 198
4 MP:0000753 paralysis 3.064E-6 1.919E-3 1.612E-2 7.674E-3 12 152
5 MP:0002446 abnormal macrophage morphology 4.348E-6 2.178E-3 1.830E-2 1.089E-2 21 454
6 MP:0000755 hindlimb paralysis 1.170E-5 4.884E-3 4.104E-2 2.930E-2 9 94
7 MP:0005403 abnormal nerve conduction 1.485E-5 5.148E-3 4.326E-2 3.720E-2 8 74
8 MP:0000136 abnormal microglial cell morphology 1.644E-5 5.148E-3 4.326E-2 4.118E-2 9 98
9 MP:0000921 demyelination 2.099E-5 5.844E-3 4.911E-2
5.259E-2
 9 101
10 MP:0000952 abnormal CNS glial cell morphology 2.798E-5 7.010E-3
5.891E-2
7.010E-2
 16 322
11 MP:0003634 abnormal glial cell morphology 4.634E-5 1.002E-2
8.417E-2
1.161E-1
 18 411
12 MP:0003690 abnormal glial cell physiology 4.798E-5 1.002E-2
8.417E-2
1.202E-1
 9 112
13 MP:0008918 microgliosis 5.305E-5 1.022E-2
8.591E-2
1.329E-1
 7 65
14 MP:0008415 abnormal neurite morphology 5.775E-5 1.033E-2
8.683E-2
1.447E-1
 18 418
15 MP:0008814 decreased nerve conduction velocity 7.034E-5 1.175E-2
9.871E-2
1.762E-1
 6 47
16 MP:0012064 abnormal astrocyte number 1.131E-4 1.770E-2
1.487E-1
2.832E-1
 9 125
17 MP:0000822 abnormal brain ventricle morphology 2.101E-4 3.096E-2
2.602E-1
5.263E-1
 14 305
18 MP:0000953 abnormal oligodendrocyte morphology 2.543E-4 3.500E-2
2.941E-1
6.370E-1
 6 59
19 MP:0000745 tremors 2.655E-4 3.500E-2
2.941E-1
6.650E-1
 14 312
20 MP:0002229 neurodegeneration 3.624E-4 4.126E-2
3.467E-1
9.079E-1
 18 484
21 MP:0010161 decreased brain cholesterol level 3.788E-4 4.126E-2
3.467E-1
9.489E-1
 3 10
22 MP:0012227 decreased brain sterol level 3.788E-4 4.126E-2
3.467E-1
9.489E-1
 3 10
23 MP:0013438 dysmyelination 3.788E-4 4.126E-2
3.467E-1
9.489E-1
 3 10
24 MP:0003354 astrocytosis 4.361E-4 4.421E-2
3.715E-1
1.000E0
 8 119
25 MP:0001402 hypoactivity 4.412E-4 4.421E-2
3.715E-1
1.000E0
 18 492
26 MP:0012065 increased astrocyte number 5.155E-4 4.966E-2
4.174E-1
1.000E0
 8 122
Show 21 more annotations

6: Domain [Display Chart] 1198 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR019577 SPARC/Testican Ca-bd-dom InterPro 6.645E-5 1.909E-2
1.463E-1
7.961E-2
 3 8
2 PF10591 SPARC Ca bdg Pfam 6.645E-5 1.909E-2
1.463E-1
7.961E-2
 3 8
3 IPR010548 BNIP3 InterPro 1.157E-4 1.909E-2
1.463E-1
1.386E-1
 2 2
4 PF06553 BNIP3 Pfam 1.157E-4 1.909E-2
1.463E-1
1.386E-1
 2 2
5 PF14429 DOCK-C2 Pfam 1.912E-4 1.909E-2
1.463E-1
2.290E-1
 3 11
6 PF06920 DHR-2 Pfam 1.912E-4 1.909E-2
1.463E-1
2.290E-1
 3 11
7 IPR026791 DOCK InterPro 1.912E-4 1.909E-2
1.463E-1
2.290E-1
 3 11
8 IPR010703 DOCK C InterPro 1.912E-4 1.909E-2
1.463E-1
2.290E-1
 3 11
9 IPR027007 DHR-1 domain InterPro 1.912E-4 1.909E-2
1.463E-1
2.290E-1
 3 11
10 IPR027357 DHR-2 InterPro 1.912E-4 1.909E-2
1.463E-1
2.290E-1
 3 11
11 PS51651 DHR 2 PROSITE 1.912E-4 1.909E-2
1.463E-1
2.290E-1
 3 11
12 PS51650 DHR 1 PROSITE 1.912E-4 1.909E-2
1.463E-1
2.290E-1
 3 11
13 3.40.50.1820 - Gene3D 3.087E-4 2.064E-2
1.582E-1
3.698E-1
 7 119
14 IPR029058 AB hydrolase InterPro 3.087E-4 2.064E-2
1.582E-1
3.698E-1
 7 119
15 IPR018237 Myelin PLP CS InterPro 3.446E-4 2.064E-2
1.582E-1
4.128E-1
 2 3
16 IPR001614 Myelin PLP InterPro 3.446E-4 2.064E-2
1.582E-1
4.128E-1
 2 3
17 PS01004 MYELIN PLP 2 PROSITE 3.446E-4 2.064E-2
1.582E-1
4.128E-1
 2 3
18 SM00002 PLP SMART 3.446E-4 2.064E-2
1.582E-1
4.128E-1
 2 3
19 PF01275 Myelin PLP Pfam 3.446E-4 2.064E-2
1.582E-1
4.128E-1
 2 3
20 PS00575 MYELIN PLP 1 PROSITE 3.446E-4 2.064E-2
1.582E-1
4.128E-1
 2 3
21 IPR004142 NDRG InterPro 6.842E-4 3.726E-2
2.856E-1
8.197E-1
 2 4
22 PF03096 Ndr Pfam 6.842E-4 3.726E-2
2.856E-1
8.197E-1
 2 4
Show 17 more annotations

7: Pathway [Display Chart] 729 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 99052 Lysosome BioSystems: KEGG 2.077E-6 1.514E-3 1.086E-2 1.514E-3 10 122
2 137952 Syndecan-3-mediated signaling events BioSystems: Pathway Interaction Database 4.303E-5 1.569E-2
1.125E-1
 3.137E-2 4 17
3 P00045 Notch signaling pathway PantherDB 7.657E-5 1.688E-2
1.210E-1
5.582E-2
 5 37
4 698758 Glial Cell Differentiation BioSystems: WikiPathways 9.260E-5 1.688E-2
1.210E-1
6.750E-2
 3 8
5 187106 Interferon gamma signaling BioSystems: REACTOME 2.099E-4 2.816E-2
2.019E-1
1.530E-1
 6 71
6 187103 Interferon Signaling BioSystems: REACTOME 2.449E-4 2.816E-2
2.019E-1
1.785E-1
 9 173
7 83062 Notch signaling pathway BioSystems: KEGG 2.704E-4 2.816E-2
2.019E-1
1.971E-1
 5 48
8 MAP00600 Sphingoglycolipid metabolism MAP00600 Sphingoglycolipid metabolism GenMAPP 3.511E-4 3.199E-2
2.294E-1
2.559E-1
 3 12
9 106050 Platelet degranulation BioSystems: REACTOME 5.585E-4 4.524E-2
3.243E-1
4.071E-1
 6 85
Show 4 more annotations

8: Pubmed [Display Chart] 24700 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16385451 A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Pubmed 6.567E-15 8.468E-11 9.054E-10 1.622E-10 19 417
2 16385451:gr A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. GeneRIF 6.857E-15 8.468E-11 9.054E-10 1.694E-10 19 418
3 12754519 Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. Pubmed 2.537E-13 2.089E-9 2.234E-8 6.268E-9 10 71
4 23142642 Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. Pubmed 4.660E-13 2.878E-9 3.077E-8 1.151E-8 8 32
5 16502470 Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Pubmed 9.246E-10 4.567E-6 4.883E-5 2.284E-5 10 160
6 16303743 Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Pubmed 2.084E-9 8.580E-6 9.173E-5 5.148E-5 14 430
7 16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Pubmed 7.104E-9 2.507E-5 2.680E-4 1.755E-4 11 257
8 21472765:gr Expression of myelin genes: comparative analysis of Oli-neu and N20.1 oligodendroglial cell lines. GeneRIF 5.912E-8 1.825E-4 1.952E-3 1.460E-3 3 3
9 19199708 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Pubmed 1.068E-7 2.932E-4 3.135E-3 2.639E-3 12 414
10 15164054 The DNA sequence and comparative analysis of human chromosome 10. Pubmed 1.550E-7 3.829E-4 4.094E-3 3.829E-3 11 348
11 15591316 Gamma-secretase complex assembly within the early secretory pathway. Pubmed 2.358E-7 4.854E-4 5.189E-3 5.824E-3 3 4
12 15591316:gr Gamma-secretase complex assembly within the early secretory pathway. GeneRIF 2.358E-7 4.854E-4 5.189E-3 5.824E-3 3 4
13 23064961 GWAS of dental caries patterns in the permanent dentition. Pubmed 5.849E-7 9.679E-4 1.035E-2 1.445E-2 5 41
14 12471034 APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes. Pubmed 5.878E-7 9.679E-4 1.035E-2 1.452E-2 3 5
15 12740439 Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Pubmed 5.878E-7 9.679E-4 1.035E-2 1.452E-2 3 5
16 16199891 Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid. Pubmed 6.684E-7 1.032E-3 1.103E-2 1.651E-2 4 18
17 17897319 Integral and associated lysosomal membrane proteins. Pubmed 7.235E-7 1.051E-3 1.124E-2 1.787E-2 7 126
18 22926577 Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. Pubmed 9.415E-7 1.292E-3 1.381E-2 2.326E-2 5 45
19 25640309 Systematic identification of molecular links between core and candidate genes in breast cancer. Pubmed 1.109E-6 1.442E-3 1.541E-2 2.739E-2 8 194
20 20471030 Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. Pubmed 1.451E-6 1.707E-3 1.825E-2 3.584E-2 5 49
21 20471030:gr Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. GeneRIF 1.451E-6 1.707E-3 1.825E-2 3.584E-2 5 49
22 12297508 Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. Pubmed 3.263E-6 2.495E-3 2.667E-2
8.060E-2
 3 8
23 21674799 ErbB2-associated changes in the lysosomal proteome. Pubmed 4.013E-6 2.495E-3 2.667E-2
9.912E-2
 5 60
24 21555518:gr The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. GeneRIF 4.013E-6 2.495E-3 2.667E-2
9.912E-2
 5 60
25 21555518 The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. Pubmed 4.013E-6 2.495E-3 2.667E-2
9.912E-2
 5 60
26 14718574 The human plasma proteome: a nonredundant list developed by combination of four separate sources. Pubmed 4.554E-6 2.495E-3 2.667E-2
1.125E-1
 7 166
27 12107410 Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. Pubmed 4.590E-6 2.495E-3 2.667E-2
1.134E-1
 6 108
28 11042152 Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Pubmed 5.090E-6 2.495E-3 2.667E-2
1.257E-1
 9 317
29 25645918 Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum. Pubmed 6.605E-6 2.495E-3 2.667E-2
1.631E-1
 4 31
30 12843241 Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability. Pubmed 6.952E-6 2.495E-3 2.667E-2
1.717E-1
 3 10
31 17601350:gr A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. GeneRIF 8.032E-6 2.495E-3 2.667E-2
1.984E-1
 6 119
32 10931946 Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. Pubmed 8.032E-6 2.495E-3 2.667E-2
1.984E-1
 6 119
33 17601350 A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. Pubmed 8.032E-6 2.495E-3 2.667E-2
1.984E-1
 6 119
34 25064009 Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Pubmed 8.537E-6 2.495E-3 2.667E-2
2.109E-1
 4 33
35 15474363 Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity. Pubmed 9.532E-6 2.495E-3 2.667E-2
2.354E-1
 3 11
36 17986144 Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling? Pubmed 9.532E-6 2.495E-3 2.667E-2
2.354E-1
 3 11
37 21492153 Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Pubmed 9.645E-6 2.495E-3 2.667E-2
2.382E-1
 4 34
38 20195357 A comprehensive resource of interacting protein regions for refining human transcription factor networks. Pubmed 1.028E-5 2.495E-3 2.667E-2
2.538E-1
 7 188
39 20047948:gr Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits. GeneRIF 1.525E-5 2.495E-3 2.667E-2
3.767E-1
 2 2
40 18768919:gr Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration. GeneRIF 1.525E-5 2.495E-3 2.667E-2
3.767E-1
 2 2
41 2467009 Interaction of myelin basic protein and proteolipid protein. Pubmed 1.525E-5 2.495E-3 2.667E-2
3.767E-1
 2 2
42 17623653:gr Mitochondrial proteins Bnip3 and Bnip3L are involved in anthrax lethal toxin-induced macrophage cell death. GeneRIF 1.525E-5 2.495E-3 2.667E-2
3.767E-1
 2 2
43 18805362:gr Tau and S100B proteins as biochemical markers of bilirubin-induced neurotoxicity in term neonates. GeneRIF 1.525E-5 2.495E-3 2.667E-2
3.767E-1
 2 2
44 16219518 Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome. Pubmed 1.525E-5 2.495E-3 2.667E-2
3.767E-1
 2 2
45 11943765:gr Presenilin 1 is required for maturation and cell surface accumulation of nicastrin. GeneRIF 1.525E-5 2.495E-3 2.667E-2
3.767E-1
 2 2
46 11264299 S100beta interaction with tau is promoted by zinc and inhibited by hyperphosphorylation in Alzheimer's disease. Pubmed 1.525E-5 2.495E-3 2.667E-2
3.767E-1
 2 2
47 12388777:gr Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype. GeneRIF 1.525E-5 2.495E-3 2.667E-2
3.767E-1
 2 2
48 15723800:gr A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs. GeneRIF 1.525E-5 2.495E-3 2.667E-2
3.767E-1
 2 2
49 19255408:gr Voxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRN. GeneRIF 1.525E-5 2.495E-3 2.667E-2
3.767E-1
 2 2
50 21753165 Trajectories of brain and hippocampal atrophy in FTD with mutations in MAPT or GRN. Pubmed 1.525E-5 2.495E-3 2.667E-2
3.767E-1
 2 2
Show 45 more annotations

9: Interaction [Display Chart] 3442 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:CLN8 CLN8 interactions 1.714E-9 5.901E-6 5.147E-5 5.901E-6 8 30
2 int:APH1B APH1B interactions 9.188E-7 1.581E-3 1.379E-2 3.163E-3 5 16

10: Cytoband [Display Chart] 179 annotations before applied cutoff / 34661 genes in category

No results to display

11: Transcription Factor Binding Site [Display Chart] 502 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 96 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1278 SPARC family genenames.org 1.277E-5 1.226E-3 6.310E-3 1.226E-3 3 8
2 1227 Phospholipases|HRAS like suppressor family genenames.org 3.777E-4 1.813E-2
9.331E-2
 3.626E-2 2 5
3 1125 WD repeat domain containing|Xeroderma pigmentosum complementation groups|Nucleotide excision repair genenames.org 1.045E-3 3.079E-2
1.585E-1
1.003E-1
 2 8
4 743 Short chain dehydrogenase/reductase superfamily genenames.org 1.283E-3 3.079E-2
1.585E-1
1.232E-1
 4 76

13: Coexpression [Display Chart] 6571 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M11011 Genes down-regulated in the temporal cortex samples from patients with major depressive disorder. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.715E-29 1.784E-25 1.671E-24 1.784E-25 29 159
2 M5793 Down-regulated genes in the canonical gene expression signature of the fibroblast core serum response (CSR) defined by the Stanford group. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.879E-19 4.528E-16 4.241E-15 1.235E-15 24 209
3 M1714 Genes enriched in oligodendrocytes in the adult mouse brain identified through correlation-based searches seeded with the oligodendrocyte cell-type specific gene expression patterns. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.067E-19 4.528E-16 4.241E-15 1.358E-15 17 74
4 M1914 Genes up-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.297E-17 7.060E-14 6.613E-13 2.824E-13 25 293
5 M988 Genes up-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.897E-16 3.807E-13 3.567E-12 1.904E-12 19 153
6 M2081 Genes down-regulated by TGFB1 [GeneID=7040] in MEF cells (embryonic fibroblast) via TGFB1R [GeneID=7046]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.846E-16 5.202E-13 4.873E-12 3.184E-12 21 207
7 M7514 Genes down-regulated in NIH3T3 cells (fibroblasts) transformed by expression of contitutively active (Q63L) form of RHOA [GeneID=387] off plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.541E-16 5.202E-13 4.873E-12 3.641E-12 27 394
8 M4628 Genes down-regulated in comparison of untreated CD25+ T effector cells at day 10 versus untreated CD25- T cells at day 10. MSigDB C7: Immunologic Signatures (v5.1) 4.273E-14 3.510E-11 3.288E-10 2.808E-10 19 200
9 M11513 Genes down-regulated in MCF10A cells (breast cancer) grown at low (mesenchymal phenotype) compared to those grown at high (epithelial, basal-like phenotype) confluency. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.165E-12 8.507E-10 7.969E-9 7.656E-9 16 154
10 M2370 Oligodendrocyte core differentiation genes: up-regulated in Oli-neo cells (oligodendroglial precursor) at 10 h after treatment with PD174265, dexamethasone or isotretinoin [PubChemID=4709, 5743, 5282379]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.532E-12 1.664E-9 1.558E-8 1.664E-8 10 40
11 GSE30971 WBP7 HET VS KO MACROPHAGE 4H LPS STIM DN Genes down-regulated in bone marrow-derived macrophages treated with LPS for 4h: heterozygous versus homozygous knockout of MLL4 [GeneID=9757]. MSigDB C7: Immunologic Signatures (v5.1) 5.062E-12 3.024E-9 2.833E-8 3.326E-8 17 198
12 M4612 Genes down-regulated in comparison of CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 10 versus CD25- T cells treated with IL4 [GeneID=3565] at 10 h. MSigDB C7: Immunologic Signatures (v5.1) 5.952E-12 3.259E-9 3.053E-8 3.911E-8 17 200
13 M10290 Genes up-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.031E-11 5.212E-9 4.882E-8 6.775E-8 13 101
14 M2116 Genes correlated with neural type of glioblastoma multiforme tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.721E-11 8.079E-9 7.568E-8 1.131E-7 14 129
15 M13206 Genes down-regulated in TC71 and EWS502 cells (Ewing's sarcoma) by EWSR1-FLI1 [GeneID=2130;2314] as inferred from RNAi knockdown of this fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.086E-11 1.352E-8 1.266E-7 2.028E-7 20 326
16 M5547 Age up-regulated genes in the human frontal cortex. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.929E-11 2.002E-8 1.875E-7 3.239E-7 18 262
17 GSE46606 UNSTIM VS CD40L IL2 IL5 DAY3 STIMULATED BCELL UP Genes up-regulated in at day 0 B cell wildtype versus CD40L and IL-2 IL-4 IL-5 stimulated at day 3 B cell wildtype. MSigDB C7: Immunologic Signatures (v5.1) 5.468E-11 2.002E-8 1.875E-7 3.593E-7 16 198
18 GSE21670 STAT3 KO VS WT CD4 TCELL TGFB IL6 TREATED DN Genes down-regulated in CD4 [GeneID=920] T cells treated with TGF beta and IL6 [GeneID=3569]: STAT3 [GeneID=6774] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v5.1) 5.898E-11 2.002E-8 1.875E-7 3.876E-7 16 199
19 M6927 Genes up-regulated in B lymphocytes: anti IgM versus CpG oligodeoxynucleotide 1826. MSigDB C7: Immunologic Signatures (v5.1) 6.359E-11 2.002E-8 1.875E-7 4.179E-7 16 200
20 GSE21670 UNTREATED VS IL6 TREATED STAT3 KO CD4 TCELL UP Genes up-regulated in CD4 [GeneID=920] T cells with STAT3 [GeneID=6774] knockout: medium versus IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v5.1) 6.359E-11 2.002E-8 1.875E-7 4.179E-7 16 200
21 M1973 Genes up-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [GeneID=9589] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.397E-11 2.002E-8 1.875E-7 4.203E-7 19 302
22 M15148 Genes down-regulated in P14 nerves of transgenic mice having hypomorhic (reduced function) allele of EGR2 [GeneID=1959]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.781E-10 1.129E-7 1.058E-6 2.485E-6 12 108
23 GSE46606 UNSTIM VS CD40L IL2 IL5 DAY1 STIMULATED BCELL UP Genes up-regulated in at day 0 B cell wildtype versus CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell wildtype. MSigDB C7: Immunologic Signatures (v5.1) 5.504E-10 1.572E-7 1.473E-6 3.617E-6 15 198
24 GSE41176 UNSTIM VS ANTI IGM STIM BCELL 1H DN Genes down-regulated in B lymphocytes: untreated versus anti-IgM for 1h. MSigDB C7: Immunologic Signatures (v5.1) 5.905E-10 1.600E-7 1.499E-6 3.880E-6 15 199
25 M2240 Genes up-regulated upon overexpression of PARVB [GeneID=29780] in MDA-MB-231 cells (breast cancer) cultured in 3D Matrigel only. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.251E-10 1.600E-7 1.499E-6 4.107E-6 21 429
26 GSE21546 UNSTIM VS ANTI CD3 STIM DP THYMOCYTES UP Genes up-regulated in double positive thymocytes: untreated versus stimulated by anti-CD3. MSigDB C7: Immunologic Signatures (v5.1) 6.332E-10 1.600E-7 1.499E-6 4.161E-6 15 200
27 M11581 Genes up-regulated in pilocytic astrocytoma compared to glioblastoma samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.120E-10 2.220E-7 2.079E-6 5.993E-6 8 35
28 M12272 Genes up-regulated in PaCa44 and CFPAC1 cells (pancreatic cancer) after treatment with decitabine [PubChem=451668], a DNA hypomethylating agent similar to azacitidine [PubChem=9444]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.282E-9 5.356E-7 5.018E-6 1.500E-5 12 126
29 M13867 Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.406E-9 5.452E-7 5.108E-6 1.581E-5 16 256
30 GSE16450 CTRL VS IFNA 6H STIM IMMATURE NEURON CELL LINE DN Genes down-regulated in immature neuron cell line: control versus interferon alpha (6h). MSigDB C7: Immunologic Signatures (v5.1) 4.513E-9 9.884E-7 9.259E-6 2.965E-5 14 196
31 M5490 Up-regulated by induction of exogenous BRCA1 in EcR-293 cells MSigDB C2: CGP Curated Gene Sets (v5.1) 5.143E-9 1.090E-6 1.021E-5 3.380E-5 14 198
32 GSE34515 CD16 NEG MONOCYTE VS DC UP Genes up-regulated in CD16- monocytes versus dendritic cells. MSigDB C7: Immunologic Signatures (v5.1) 5.488E-9 1.099E-6 1.029E-5 3.606E-5 14 199
33 GSE26343 UNSTIM VS LPS STIM MACROPHAGE DN Genes down-regulated in bone marrow-derived macrophages: control versus stimulated with LPS. MSigDB C7: Immunologic Signatures (v5.1) 5.853E-9 1.099E-6 1.029E-5 3.846E-5 14 200
34 GSE37532 TREG VS TCONV PPARG KO CD4 TCELL FROM VISCERAL ADIPOSE TISSUE DN Genes down-regulated in visceral adipose tissue from aged PPARG [GeneID=5468] knockout mice: T reg versus T conv. MSigDB C7: Immunologic Signatures (v5.1) 5.853E-9 1.099E-6 1.029E-5 3.846E-5 14 200
35 GSE37532 WT VS PPARG KO VISCERAL ADIPOSE TISSUE TREG DN Genes down-regulated in T reg from visceral adipose tissue of aged mice: wildtype versus PPARG [GeneID=5468] knockout. MSigDB C7: Immunologic Signatures (v5.1) 5.853E-9 1.099E-6 1.029E-5 3.846E-5 14 200
36 M1240 Genes down-regulated in early vs late brain tumors induced by retroviral delivery of PDGFB [GeneID=5155]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.715E-9 1.408E-6 1.319E-5 5.069E-5 8 45
37 M15606 Genes up-regulated in adult fibroblasts with inactivated RB1 [GeneID=5925] by Cre-lox: acute loss of function (LOF) of RB1. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.475E-8 2.619E-6 2.453E-5 9.691E-5 14 215
38 M3804 Genes up-regulated in normal hematopoietic progenitors by RUNX1-RUNX1T1 [GeneID=861;862] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.984E-8 3.430E-6 3.214E-5 1.304E-4 13 185
39 M2013 Genes with low-CpG-density promoters (LCP) bearing histone H3 trimethylation mark at K4 (H3K4me3) in neural progenitor cells (NPC). MSigDB C2: CGP Curated Gene Sets (v5.1) 3.838E-8 6.466E-6 6.057E-5 2.522E-4 19 445
40 M2144 Genes consistently overexpressed with age, based on meta-analysis of microarray data. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.025E-8 6.612E-6 6.194E-5 2.645E-4 8 55
41 GSE41176 UNSTIM VS ANTI IGM STIM BCELL 3H DN Genes down-regulated in B lymphocytes: untreated versus anti-IgM for 3h. MSigDB C7: Immunologic Signatures (v5.1) 4.444E-8 6.995E-6 6.553E-5 2.920E-4 13 198
42 M4606 Genes down-regulated in comparison of CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 7 versus CD25- T cells treated with IL4 [GeneID=3565] at day 7. MSigDB C7: Immunologic Signatures (v5.1) 4.716E-8 6.995E-6 6.553E-5 3.099E-4 13 199
43 GSE21546 UNSTIM VS ANTI CD3 STIM SAP1A KO DP THYMOCYTES UP Genes up-regulated in double positive thymocytes with ELK4 [GeneID=2005] knockout: untreated versus stimulated by anti-CD3. MSigDB C7: Immunologic Signatures (v5.1) 4.716E-8 6.995E-6 6.553E-5 3.099E-4 13 199
44 GSE45739 NRAS KO VS WT ACD3 ACD28 STIM CD4 TCELL DN Genes down-regulated in activated CD4 [GeneID=920] T cells: NRAS [GeneID=4893] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v5.1) 4.716E-8 6.995E-6 6.553E-5 3.099E-4 13 199
45 GSE43863 TH1 VS LY6C INT CXCR5POS EFFECTOR CD4 TCELL DN Genes down-regulated in CD4 [GeneID=920] SMARTA effector T cells during acute infection of LCMV: Th1 versus Ly6c int CXCR5+ [GeneID=643]. MSigDB C7: Immunologic Signatures (v5.1) 5.003E-8 6.995E-6 6.553E-5 3.288E-4 13 200
46 GSE21927 SPLEEN C57BL6 VS EL4 TUMOR BALBC MONOCYTES UP Genes up-regulated in CD11b+ from spleen of healthy C57BL6 versus CD11b+ cells from tumors of C57BL6 mice bearing EL4 lymphoma. MSigDB C7: Immunologic Signatures (v5.1) 5.003E-8 6.995E-6 6.553E-5 3.288E-4 13 200
47 M4600 Genes down-regulated in comparison of CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 3 versus CD25- T cells incubated with IL4 [GeneID=3565] at day 3. MSigDB C7: Immunologic Signatures (v5.1) 5.003E-8 6.995E-6 6.553E-5 3.288E-4 13 200
48 M2477 Genes up-regulated hT-RPE cells (immortalized retinal pigment epithelium) by MYC [GeneID=4609]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.583E-8 7.643E-6 7.160E-5 3.669E-4 14 239
49 M3654 Genes up-regulated in samples with systolic heart failure compared to normal hearts. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.035E-8 1.212E-5 1.135E-4 5.937E-4 18 422
50 M29 Genes whose expression positively correlated with that of SMARCA2 [GeneID=6595] in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.696E-8 1.274E-5 1.194E-4 6.371E-4 18 424
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2953 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 oligodendrocytes Top 500 All oligodendrocytes Top 500 All Brain Map - Barres 3.108E-78 9.177E-75 7.863E-74 9.177E-75 81 498
2 oligodendrocytes Top 500 Cluster 0 oligodendrocytes Top 500 Cluster 0 Brain Map - Barres 6.459E-33 9.537E-30 8.171E-29 1.907E-29 31 146
3 BM Top 100 - subthalamic nucleus BM Top 100 - subthalamic nucleus Body Map 8.486E-20 8.353E-17 7.157E-16 2.506E-16 17 68
4 oligodendrocytes Top 500 Cluster 2 oligodendrocytes Top 500 Cluster 2 Brain Map - Barres 2.482E-19 1.832E-16 1.570E-15 7.328E-16 16 59
5 oligodendrocytes Top 500 Cluster 1 oligodendrocytes Top 500 Cluster 1 Brain Map - Barres 7.487E-19 4.422E-16 3.789E-15 2.211E-15 14 40
6 BM Top 100 - nodose nucleus BM Top 100 - nodose nucleus Body Map 8.077E-17 3.975E-14 3.406E-13 2.385E-13 15 67
7 BM Top 100 - corpus callosum BM Top 100 - corpus callosum Body Map 2.513E-15 1.060E-12 9.083E-12 7.421E-12 14 67
8 endothelial SubClass MFSD2-hi Top 500 Cluster 2 endothelial SubClass MFSD2-hi Top 500 Cluster 2 Brain Map - Barres 5.092E-14 1.880E-11 1.610E-10 1.504E-10 11 38
9 oligodendrocytes Top 500 Cluster 4 oligodendrocytes Top 500 Cluster 4 Brain Map - Barres 1.909E-13 6.265E-11 5.368E-10 5.639E-10 13 72
10 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 3.416E-13 1.009E-10 8.643E-10 1.009E-9 27 493
11 54Dn SubClass 54Dn 2 Top 500 All 54Dn SubClass 54Dn 2 Top 500 All Brain Map - Allen iN 3.760E-13 1.009E-10 8.647E-10 1.110E-9 27 495
12 54SK Top 500 All 54SK Top 500 All Brain Map - Allen iN 1.813E-12 4.461E-10 3.822E-9 5.353E-9 26 488
13 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 2.390E-12 5.428E-10 4.651E-9 7.057E-9 26 494
14 astrocytes Top 500 All astrocytes Top 500 All Brain Map - Barres 2.618E-12 5.522E-10 4.731E-9 7.731E-9 26 496
15 BM Top 100 - midbrain BM Top 100 - midbrain Body Map 4.504E-12 8.868E-10 7.598E-9 1.330E-8 12 72
16 GSM605862 500 Myeloid Cells, MF.Thio5.II-480hi.PC, CD115+ MHC II- F480hi Siglec F-, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 8.836E-12 1.631E-9 1.397E-8 2.609E-8 24 441
17 GSM605865 500 Myeloid Cells, MF.Thio5.II-480int.PC, CD115+ MHCII- F480int SiglecF- CD11c+, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 1.813E-9 3.099E-7 2.655E-6 5.355E-6 21 437
18 GSM605850 500 Myeloid Cells, MF.II-480hi.PC, F4/80hi CD115hi CD11b+ MHC II- CD11c-, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 1.889E-9 3.099E-7 2.655E-6 5.578E-6 21 438
19 gudmap kidney adult RenMedVasc Tie2 500 kidney adult RenMedVasc Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.662E-9 7.246E-7 6.208E-6 1.377E-5 20 417
20 astrocytes Top 500 Cluster 0 astrocytes Top 500 Cluster 0 Brain Map - Barres 5.161E-9 7.620E-7 6.529E-6 1.524E-5 9 59
21 gudmap kidney adult RenCorpuscGlomer k3 1000 kidney adult RenCorpuscGlomer k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.828E-9 8.195E-7 7.022E-6 1.721E-5 14 192
22 GSM605856 500 Myeloid Cells, MF.Thio5.II+480int.PC, CD115+ MHC II+ F480lo SiglecF- CD11c+, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 8.802E-9 1.182E-6 1.012E-5 2.599E-5 20 433
23 Lungmap Mouse e16.5 Matrix fibroblast SubClass Mature fibroblast 1 Top 500 Cluster 0 Mouse Lung E16.5 Matrix Fibroblast Mature fibroblast 1 c0 Lungmap Mouse Single Cell (Lungmap.net) 3.772E-8 4.672E-6 4.003E-5 1.114E-4 11 125
24 80Dn SubClass 80Dn 5 Top 500 All 80Dn SubClass 80Dn 5 Top 500 All Brain Map - Allen iN 3.955E-8 4.672E-6 4.003E-5 1.168E-4 20 474
25 80Dn SubClass 80Dn 5 Top 500 Cluster 0 80Dn SubClass 80Dn 5 Top 500 Cluster 0 Brain Map - Allen iN 3.955E-8 4.672E-6 4.003E-5 1.168E-4 20 474
26 54SK SubClass 54SK 3 Top 500 All 54SK SubClass 54SK 3 Top 500 All Brain Map - Allen iN 5.202E-8 5.909E-6 5.063E-5 1.536E-4 20 482
27 Lungmap Mouse e16.5 Epithelial SubClass Noncycling AT2 Precursor Top 500 All Mouse Lung E16.5 Epithelial Noncycling AT2 Precursor top 500 Lungmap Mouse Single Cell (Lungmap.net) 6.199E-8 6.779E-6 5.809E-5 1.830E-4 18 395
28 26Dn SubClass 26Dn 2 Top 500 All 26Dn SubClass 26Dn 2 Top 500 All Brain Map - Allen iN 8.848E-8 9.332E-6 7.995E-5 2.613E-4 20 498
29 BM Top 100 - substantia nigra BM Top 100 - substantia nigra Body Map 1.866E-7 1.900E-5 1.628E-4 5.511E-4 8 64
30 BM Top 100 - medulla BM Top 100 - medulla Body Map 2.110E-7 2.077E-5 1.780E-4 6.232E-4 8 65
31 BM Top 100 - spinal cord BM Top 100 - spinal cord Body Map 2.382E-7 2.269E-5 1.944E-4 7.033E-4 8 66
32 OPC Top 500 All OPC Top 500 All Brain Map - Barres 3.658E-7 3.376E-5 2.892E-4 1.080E-3 19 494
33 gudmap developingGonad e11.5 testes k2 1000 DevelopingGonad e11.5 testes emap-3226 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.177E-7 4.632E-5 3.969E-4 1.529E-3 12 197
34 gudmap developingGonad e11.5 testes and mesonephros k4 1000 DevelopingGonad e11.5 testes and mesonephros emap-3226 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.015E-7 5.224E-5 4.476E-4 1.776E-3 11 164
35 gudmap dev gonad e13.5 M SertoliCell Sox9 k4 1000 dev gonad e13.5 M SertoliCell Sox9 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 9.041E-7 7.478E-5 6.407E-4 2.670E-3 18 474
36 80Dn Top 500 Cluster 4 80Dn Top 500 Cluster 4 Brain Map - Allen iN 9.116E-7 7.478E-5 6.407E-4 2.692E-3 9 106
37 gudmap kidney P2 CapMes Crym k4 1000 kidney P2 CapMes Crym k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.421E-6 1.095E-4 9.380E-4 4.197E-3 8 83
38 80Dn Top 500 Cluster 3 80Dn Top 500 Cluster 3 Brain Map - Allen iN 1.450E-6 1.095E-4 9.380E-4 4.283E-3 5 21
39 gudmap RNAseq p2 Glomerlular Endothelial 2500 K4 gudmap RNAseq p2 Glomerlular Endothelial 2500 K4 Gudmap RNAseq 1.476E-6 1.095E-4 9.380E-4 4.359E-3 16 392
40 gudmap kidney adult Mesangium Meis k4 1000 kidney adult Mesangium Meis k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.483E-6 1.095E-4 9.380E-4 4.379E-3 13 258
41 Lungmap Mouse e18.5 Epithelial (GSE52583) SubClass Bi-potential Top 500 All Mouse Lung E18.5 Epithelial Bi-potential top 500 Lungmap Mouse Single Cell (Lungmap.net) 2.045E-6 1.473E-4 1.262E-3 6.040E-3 16 402
42 gudmap kidney adult RenMedVasc Tie2 k1 1000 kidney adult RenMedVasc Tie2 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.509E-6 1.764E-4 1.511E-3 7.408E-3 7 63
43 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.636E-6 1.810E-4 1.551E-3 7.784E-3 16 410
44 gudmap developingGonad e18.5 testes 500 DevelopingGonad e18.5 testes emap-11164 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.805E-6 1.883E-4 1.613E-3 8.285E-3 16 412
45 54Dn SubClass 54Dn 2 Top 500 Cluster 2 54Dn SubClass 54Dn 2 Top 500 Cluster 2 Brain Map - Allen iN 2.959E-6 1.900E-4 1.628E-3 8.737E-3 5 24
46 gudmap developingGonad P2 testes 1000 k4 DevelopingGonad P2 testes emap-30171 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.960E-6 1.900E-4 1.628E-3 8.740E-3 14 319
47 gudmap kidney adult CortVasc Tie2 500 kidney adult CortVasc Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.375E-6 2.121E-4 1.817E-3 9.967E-3 16 418
48 gudmap dev gonad e13.5 F SupCellPrec Sry k2 500 dev gonad e13.5 F SupCellPrec Sry k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.945E-6 2.427E-4 2.080E-3 1.165E-2 10 161
49 GSM854294 500 Myeloid Cells, DC.II+480lo.PC, F4/80lo MHC II+ CD11c+ CD115+, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 4.046E-6 2.439E-4 2.089E-3 1.195E-2 16 424
50 GSM538282 500 Myeloid Cells, MF.Lu, CD11chi CD11b- CD103- MHCII- SiglecF+, Lung, avg-3 Immgen.org, GSE15907 4.169E-6 2.462E-4 2.110E-3 1.231E-2 16 425
Show 45 more annotations

15: Computational [Display Chart] 497 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GCM MAPK10 Neighborhood of MAPK10 MSigDb: C4 - CGN: Cancer Gene Neighborhood 7.534E-16 3.744E-13 2.541E-12 3.744E-13 17 76
2 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 1.776E-12 4.414E-10 2.996E-9 8.827E-10 27 351
3 GCM PTK2 Neighborhood of PTK2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 8.286E-9 1.373E-6 9.317E-6 4.118E-6 14 130
4 GCM MAP4K4 Neighborhood of MAP4K4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.057E-8 3.829E-6 2.599E-5 2.016E-5 14 147
5 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 4.586E-8 3.829E-6 2.599E-5 2.279E-5 22 378
6 GCM DLG1 Neighborhood of DLG1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.622E-8 3.829E-6 2.599E-5 2.297E-5 10 66
7 module 568 Genes in module 568 MSigDb: C4 - CM: Cancer Modules 1.062E-5 7.542E-4 5.119E-3 5.279E-3 8 71
8 module 491 Genes in module 491 MSigDb: C4 - CM: Cancer Modules 1.601E-5 9.946E-4 6.750E-3 7.957E-3 8 75
9 GCM AQP4 Neighborhood of AQP4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.707E-5 2.600E-3 1.764E-2 2.340E-2 6 44
10 GCM PTPRD Neighborhood of PTPRD MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.101E-4 5.473E-3 3.714E-2
5.473E-2
 6 51
11 GCM SIRT2 Neighborhood of SIRT2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.548E-4 1.603E-2
1.088E-1
1.764E-1
 5 41
Show 6 more annotations

16: MicroRNA [Display Chart] 1262 annotations before applied cutoff / 19844 genes in category

No results to display

17: Drug [Display Chart] 21549 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone CTD 2.779E-15 5.481E-11 5.785E-10 5.988E-11 24 320
2 1065 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 5.087E-15 5.481E-11 5.785E-10 1.096E-10 19 180
3 7550 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.197E-12 7.698E-9 8.125E-8 2.579E-8 17 183
4 1668 UP wortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT HG-U133A Broad Institute CMAP 1.429E-12 7.698E-9 8.125E-8 3.079E-8 17 185
5 1023 UP wortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.857E-12 8.002E-9 8.446E-8 4.001E-8 17 188
6 1050 UP Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A EA Broad Institute CMAP 6.031E-12 2.166E-8 2.286E-7 1.300E-7 16 173
7 1077 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.204E-11 3.708E-8 3.914E-7 2.595E-7 16 181
8 1074 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.424E-11 3.836E-8 4.049E-7 3.069E-7 16 183
9 1637 UP Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.680E-11 3.875E-8 4.091E-7 3.621E-7 16 185
10 1664 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.824E-11 3.875E-8 4.091E-7 3.930E-7 16 186
11 5233 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.978E-11 3.875E-8 4.091E-7 4.263E-7 16 187
12 6998 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 2.518E-11 4.522E-8 4.773E-7 5.426E-7 16 190
13 2068 UP Mianserine hydrochloride [21535-47-7]; Up 200; 13.2uM; PC3; HT HG-U133A Broad Institute CMAP 3.451E-11 5.720E-8 6.038E-7 7.436E-7 16 194
14 3243 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 8.371E-11 1.288E-7 1.360E-6 1.804E-6 15 175
15 1072 UP Trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP 9.839E-11 1.413E-7 1.492E-6 2.120E-6 15 177
16 6993 UP Trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.154E-10 1.554E-7 1.641E-6 2.487E-6 15 179
17 1661 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.460E-10 1.851E-7 1.954E-6 3.147E-6 15 182
18 1007 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.704E-10 2.041E-7 2.154E-6 3.673E-6 15 184
19 1398 UP Dihydroergotamine tartrate [5989-77-5]; Up 200; 3uM; HL60; HG-U133A Broad Institute CMAP 4.874E-10 5.528E-7 5.835E-6 1.050E-5 14 167
20 1000 UP SAHA; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 5.705E-10 6.147E-7 6.488E-6 1.229E-5 14 169
21 1058 UP SAHA; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 7.196E-10 7.384E-7 7.794E-6 1.551E-5 14 172
22 1019 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 8.379E-10 7.851E-7 8.287E-6 1.806E-5 14 174
23 7179 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 8.379E-10 7.851E-7 8.287E-6 1.806E-5 14 174
24 3462 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.049E-9 9.418E-7 9.941E-6 2.260E-5 14 177
25 5336 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.215E-9 1.048E-6 1.106E-5 2.619E-5 14 179
26 2410 UP Perhexiline maleate [6724-53-4]; Up 200; 10.2uM; HL60; HT HG-U133A Broad Institute CMAP 1.307E-9 1.084E-6 1.144E-5 2.817E-5 14 180
27 1081 UP wortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.742E-9 1.391E-6 1.468E-5 3.755E-5 14 184
28 6916 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.870E-9 1.439E-6 1.519E-5 4.029E-5 14 185
29 1221 UP Rapamycin; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 3.030E-9 2.178E-6 2.299E-5 6.529E-5 14 192
30 6133 DN Verteporfin [129497-78-5]; Down 200; 2.8uM; HL60; HT HG-U133A Broad Institute CMAP 3.033E-9 2.178E-6 2.299E-5 6.535E-5 13 160
31 7001 UP Rapamycin; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 3.465E-9 2.409E-6 2.542E-5 7.466E-5 14 194
32 5018 UP Metixene hydrochloride [1553-34-0]; Up 200; 11.6uM; MCF7; HT HG-U133A Broad Institute CMAP 3.805E-9 2.562E-6 2.705E-5 8.199E-5 13 163
33 1672 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 7.840E-9 4.992E-6 5.270E-5 1.690E-4 13 173
34 D012524 Sarin CTD 7.877E-9 4.992E-6 5.270E-5 1.697E-4 16 281
35 977 UP wortmannin; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP 8.406E-9 5.032E-6 5.311E-5 1.811E-4 13 174
36 5572 UP Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 8.406E-9 5.032E-6 5.311E-5 1.811E-4 13 174
37 3428 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 9.008E-9 5.108E-6 5.392E-5 1.941E-4 13 175
38 869 UP wortmannin; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP 9.008E-9 5.108E-6 5.392E-5 1.941E-4 13 175
39 4954 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.033E-8 5.300E-6 5.594E-5 2.226E-4 13 177
40 3312 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.033E-8 5.300E-6 5.594E-5 2.226E-4 13 177
41 6784 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.033E-8 5.300E-6 5.594E-5 2.226E-4 13 177
42 1645 UP SAHA; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.033E-8 5.300E-6 5.594E-5 2.226E-4 13 177
43 7005 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.183E-8 5.926E-6 6.255E-5 2.548E-4 13 179
44 7407 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.264E-8 6.193E-6 6.537E-5 2.725E-4 13 180
45 2675 UP prochlorperazine dimaleate salt; Up 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP 1.351E-8 6.331E-6 6.682E-5 2.912E-4 13 181
46 6276 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.351E-8 6.331E-6 6.682E-5 2.912E-4 13 181
47 C095105 bexarotene CTD 1.567E-8 7.185E-6 7.584E-5 3.377E-4 19 425
48 6995 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.997E-8 8.964E-6 9.462E-5 4.303E-4 13 187
49 5239 UP Rapamycin; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 2.128E-8 9.358E-6 9.878E-5 4.585E-4 13 188
50 911 UP wortmannin; Up 200; 0.01uM; MCF7; HT HG-U133A EA Broad Institute CMAP 2.267E-8 9.578E-6 1.011E-4 4.885E-4 13 189
Show 45 more annotations

18: Disease [Display Chart] 2254 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0085078 Lysosomal Storage Diseases DisGeNET BeFree 6.810E-9 1.535E-5 1.274E-4 1.535E-5 10 74
2 umls:C0023794 Lipoidosis DisGeNET Curated 8.736E-7 9.846E-4 8.170E-3 1.969E-3 6 31
3 umls:C0393571 Multiple System Atrophy DisGeNET BeFree 3.503E-6 2.291E-3 1.901E-2 7.896E-3 8 84
4 umls:C0333463 Senile Plaques DisGeNET Curated 4.066E-6 2.291E-3 1.901E-2 9.166E-3 13 254
5 umls:C0752347 Lewy Body Disease DisGeNET Curated 7.655E-6 2.940E-3 2.439E-2 1.725E-2 9 123
6 umls:C0011303 Demyelinating Diseases DisGeNET Curated 7.825E-6 2.940E-3 2.439E-2 1.764E-2 7 67
7 umls:C0162534 Prion Diseases DisGeNET Curated 1.519E-5 4.893E-3 4.060E-2 3.425E-2 7 74
8 umls:C0497327 Dementia DisGeNET Curated 1.809E-5 5.095E-3 4.228E-2 4.076E-2 14 336
9 umls:C0037019 Shy-Drager Syndrome DisGeNET Curated 2.339E-5 5.858E-3 4.861E-2
5.272E-2
 7 79
10 umls:C0008384 Cholesterol Ester Storage Disease DisGeNET Curated 2.840E-5 6.158E-3
5.110E-2
6.400E-2
 4 17
11 umls:C0338656 Impaired cognition DisGeNET Curated 3.005E-5 6.158E-3
5.110E-2
6.774E-2
 15 399
12 umls:C0751706 Primary Progressive Nonfluent Aphasia DisGeNET Curated 4.240E-5 7.964E-3
6.608E-2
9.556E-2
 3 7
13 umls:C0205711 Pelizaeus-Merzbacher Disease DisGeNET Curated 8.366E-5 1.253E-2
1.040E-1
1.886E-1
 4 22
14 umls:C2936349 Plaque, Amyloid DisGeNET Curated 8.784E-5 1.253E-2
1.040E-1
1.980E-1
 10 207
15 umls:C0011265 Presenile dementia DisGeNET BeFree 1.007E-4 1.253E-2
1.040E-1
2.270E-1
 12 298
16 umls:C0014072 Experimental Autoimmune Encephalomyelitis DisGeNET Curated 1.101E-4 1.253E-2
1.040E-1
2.481E-1
 13 348
17 umls:C0751779 Action Myoclonus-Renal Failure Syndrome DisGeNET Curated 1.168E-4 1.253E-2
1.040E-1
2.632E-1
 2 2
18 600274 FRONTOTEMPORAL DEMENTIA; FTD OMIM 1.168E-4 1.253E-2
1.040E-1
2.632E-1
 2 2
19 umls:C2673635 Combined Saposin Deficiency DisGeNET Curated 1.168E-4 1.253E-2
1.040E-1
2.632E-1
 2 2
20 cv:C0338451 Frontotemporal dementia Clinical Variations 1.168E-4 1.253E-2
1.040E-1
2.632E-1
 2 2
21 cv:C0236642 Pick's disease Clinical Variations 1.168E-4 1.253E-2
1.040E-1
2.632E-1
 2 2
22 umls:C0338462 Semantic Dementia DisGeNET Curated 1.419E-4 1.454E-2
1.207E-1
3.199E-1
 3 10
23 umls:C0235946 Cerebral atrophy DisGeNET BeFree 2.146E-4 2.103E-2
1.745E-1
4.838E-1
 6 79
24 umls:C0002726 Amyloidosis DisGeNET Curated 2.290E-4 2.150E-2
1.784E-1
5.161E-1
 7 113
25 umls:C0270922 Peripheral demyelinating neuropathy DisGeNET BeFree 2.560E-4 2.220E-2
1.842E-1
5.771E-1
 4 29
26 umls:C0243010 Viral Encephalitis DisGeNET BeFree 2.561E-4 2.220E-2
1.842E-1
5.771E-1
 3 12
27 umls:C0027765 nervous system disorder DisGeNET Curated 2.898E-4 2.419E-2
2.007E-1
6.531E-1
 14 436
28 umls:C0005956 Bone Marrow Diseases DisGeNET Curated 3.335E-4 2.613E-2
2.168E-1
7.517E-1
 4 31
29 umls:C0268255 Farber Lipogranulomatosis DisGeNET Curated 3.478E-4 2.613E-2
2.168E-1
7.838E-1
 2 3
30 umls:C1840560 Hidradenitis suppurativa, familial DisGeNET Curated 3.478E-4 2.613E-2
2.168E-1
7.838E-1
 2 3
31 umls:C0220756 Niemann-Pick Disease, Type C DisGeNET Curated 3.779E-4 2.748E-2
2.280E-1
8.519E-1
 4 32
32 umls:C0268407 Senile cardiac amyloidosis DisGeNET BeFree 5.170E-4 3.642E-2
3.022E-1
1.000E0
 3 15
33 umls:C0085220 Cerebral Amyloid Angiopathy DisGeNET Curated 6.655E-4 4.187E-2
3.475E-1
1.000E0
 4 37
34 umls:C0238190 Inclusion Body Myositis (disorder) DisGeNET Curated 6.891E-4 4.187E-2
3.475E-1
1.000E0
 5 65
35 umls:C0279980 Extraosseous Ewings sarcoma-primitive neuroepithelial tumor DisGeNET BeFree 6.891E-4 4.187E-2
3.475E-1
1.000E0
 5 65
36 umls:C0240735 Personality change DisGeNET BeFree 6.906E-4 4.187E-2
3.475E-1
1.000E0
 2 4
37 umls:C0149521 Pancreatitis, Chronic DisGeNET Curated 7.573E-4 4.187E-2
3.475E-1
1.000E0
 10 271
38 umls:C1392786 Cognitive changes DisGeNET BeFree 7.605E-4 4.187E-2
3.475E-1
1.000E0
 3 17
39 umls:C0011570 Mental Depression DisGeNET Curated 7.828E-4 4.187E-2
3.475E-1
1.000E0
 14 482
40 umls:C0028756 Obesity, Morbid DisGeNET Curated 8.046E-4 4.187E-2
3.475E-1
1.000E0
 6 101
41 umls:C0206687 Carcinoma, Endometrioid DisGeNET Curated 8.473E-4 4.187E-2
3.475E-1
1.000E0
 6 102
42 umls:C0282513 Primary Progressive Aphasia (disorder) DisGeNET Curated 9.053E-4 4.187E-2
3.475E-1
1.000E0
 3 18
43 umls:C1970945 MAJOR AFFECTIVE DISORDER 6 DisGeNET Curated 9.056E-4 4.187E-2
3.475E-1
1.000E0
 5 69
44 umls:C1970943 MAJOR AFFECTIVE DISORDER 4 DisGeNET Curated 9.056E-4 4.187E-2
3.475E-1
1.000E0
 5 69
45 umls:C2700440 MAJOR AFFECTIVE DISORDER 9 DisGeNET Curated 9.056E-4 4.187E-2
3.475E-1
1.000E0
 5 69
46 umls:C1970944 MAJOR AFFECTIVE DISORDER 5 DisGeNET Curated 9.056E-4 4.187E-2
3.475E-1
1.000E0
 5 69
47 umls:C2700438 MAJOR AFFECTIVE DISORDER 7 DisGeNET Curated 9.056E-4 4.187E-2
3.475E-1
1.000E0
 5 69
48 umls:C2700439 MAJOR AFFECTIVE DISORDER 8 DisGeNET Curated 9.056E-4 4.187E-2
3.475E-1
1.000E0
 5 69
49 umls:C1621958 Glioblastoma Multiforme DisGeNET BeFree 9.103E-4 4.187E-2
3.475E-1
1.000E0
 13 434
50 umls:C0740457 Malignant neoplasm of kidney DisGeNET BeFree 1.019E-3 4.557E-2
3.781E-1
1.000E0
 12 385
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