Toppgene analysis for aggregated_1964_log, IC21, negative side

Go To Start Page
Input Parameters [Show Detail]
Training Results [Expand All] [Download All] [Sparse Matrix]
Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 172 annotations before applied cutoff / 18819 genes in category

No results to display

2: GO: Biological Process [Display Chart] 1083 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0042254 ribosome biogenesis 5.878E-7 4.926E-4 3.726E-3 6.366E-4 8 322
2 GO:0022613 ribonucleoprotein complex biogenesis 9.097E-7 4.926E-4 3.726E-3 9.852E-4 9 468
3 GO:0034470 ncRNA processing 2.922E-6 8.295E-4 6.276E-3 3.164E-3 8 399
4 GO:1904872 regulation of telomerase RNA localization to Cajal body 4.987E-6 8.295E-4 6.276E-3 5.401E-3 3 15
5 GO:1904874 positive regulation of telomerase RNA localization to Cajal body 4.987E-6 8.295E-4 6.276E-3 5.401E-3 3 15
6 GO:0090670 RNA localization to Cajal body 6.128E-6 8.295E-4 6.276E-3 6.636E-3 3 16
7 GO:0090672 telomerase RNA localization 6.128E-6 8.295E-4 6.276E-3 6.636E-3 3 16
8 GO:0090671 telomerase RNA localization to Cajal body 6.128E-6 8.295E-4 6.276E-3 6.636E-3 3 16
9 GO:0070199 establishment of protein localization to chromosome 1.916E-5 2.306E-3 1.745E-2 2.075E-2 3 23
10 GO:0006364 rRNA processing 2.633E-5 2.852E-3 2.157E-2 2.852E-2 6 260
11 GO:0016072 rRNA metabolic process 3.056E-5 3.009E-3 2.277E-2 3.310E-2 6 267
12 GO:0033044 regulation of chromosome organization 6.298E-5 5.684E-3 4.300E-2
6.820E-2
 6 304
13 GO:0010918 positive regulation of mitochondrial membrane potential 7.633E-5 6.359E-3 4.810E-2
8.266E-2
 2 6
14 GO:0010216 maintenance of DNA methylation 1.067E-4 8.254E-3
6.244E-2
1.156E-1
 2 7
15 GO:1904869 regulation of protein localization to Cajal body 1.421E-4 9.616E-3
7.275E-2
1.539E-1
 2 8
16 GO:1904871 positive regulation of protein localization to Cajal body 1.421E-4 9.616E-3
7.275E-2
1.539E-1
 2 8
17 GO:1903405 protein localization to nuclear body 1.824E-4 9.876E-3
7.472E-2
1.975E-1
 2 9
18 GO:1904851 positive regulation of establishment of protein localization to telomere 1.824E-4 9.876E-3
7.472E-2
1.975E-1
 2 9
19 GO:1904867 protein localization to Cajal body 1.824E-4 9.876E-3
7.472E-2
1.975E-1
 2 9
20 GO:1990173 protein localization to nucleoplasm 1.824E-4 9.876E-3
7.472E-2
1.975E-1
 2 9
21 GO:0070203 regulation of establishment of protein localization to telomere 2.277E-4 1.121E-2
8.478E-2
2.465E-1
 2 10
22 GO:0090308 regulation of methylation-dependent chromatin silencing 2.277E-4 1.121E-2
8.478E-2
2.465E-1
 2 10
23 GO:0070202 regulation of establishment of protein localization to chromosome 2.778E-4 1.308E-2
9.897E-2
3.009E-1
 2 11
24 GO:1904816 positive regulation of protein localization to chromosome, telomeric region 3.329E-4 1.502E-2
1.137E-1
3.606E-1
 2 12
25 GO:0034502 protein localization to chromosome 3.665E-4 1.549E-2
1.172E-1
3.970E-1
 3 61
26 GO:2000573 positive regulation of DNA biosynthetic process 3.846E-4 1.549E-2
1.172E-1
4.165E-1
 3 62
27 GO:0006596 polyamine biosynthetic process 3.929E-4 1.549E-2
1.172E-1
4.255E-1
 2 13
28 GO:0009201 ribonucleoside triphosphate biosynthetic process 4.420E-4 1.549E-2
1.172E-1
4.787E-1
 3 65
29 GO:2001252 positive regulation of chromosome organization 4.496E-4 1.549E-2
1.172E-1
4.870E-1
 4 157
30 GO:0060252 positive regulation of glial cell proliferation 4.577E-4 1.549E-2
1.172E-1
4.957E-1
 2 14
31 GO:0045838 positive regulation of membrane potential 4.577E-4 1.549E-2
1.172E-1
4.957E-1
 2 14
32 GO:1904814 regulation of protein localization to chromosome, telomeric region 4.577E-4 1.549E-2
1.172E-1
4.957E-1
 2 14
33 GO:0032204 regulation of telomere maintenance 5.048E-4 1.632E-2
1.234E-1
5.467E-1
 3 68
34 GO:0006595 polyamine metabolic process 5.273E-4 1.632E-2
1.234E-1
5.711E-1
 2 15
35 GO:0070200 establishment of protein localization to telomere 5.273E-4 1.632E-2
1.234E-1
5.711E-1
 2 15
36 GO:0034644 cellular response to UV 6.215E-4 1.870E-2
1.414E-1
6.730E-1
 3 73
37 GO:0009142 nucleoside triphosphate biosynthetic process 7.263E-4 2.126E-2
1.608E-1
7.866E-1
 3 77
38 GO:0042401 cellular biogenic amine biosynthetic process 9.473E-4 2.700E-2
2.043E-1
1.000E0
 2 20
39 GO:0009309 amine biosynthetic process 1.046E-3 2.903E-2
2.196E-1
1.000E0
 2 21
40 GO:0031935 regulation of chromatin silencing 1.148E-3 3.104E-2
2.348E-1
1.000E0
 2 22
41 GO:0051054 positive regulation of DNA metabolic process 1.175E-3 3.104E-2
2.348E-1
1.000E0
 4 203
42 GO:0045740 positive regulation of DNA replication 1.295E-3 3.340E-2
2.527E-1
1.000E0
 3 94
43 GO:0006346 methylation-dependent chromatin silencing 1.368E-3 3.446E-2
2.607E-1
1.000E0
 2 24
44 GO:0051052 regulation of DNA metabolic process 1.502E-3 3.619E-2
2.738E-1
1.000E0
 5 370
45 GO:2000278 regulation of DNA biosynthetic process 1.504E-3 3.619E-2
2.738E-1
1.000E0
 3 99
46 GO:0070198 protein localization to chromosome, telomeric region 1.732E-3 3.992E-2
3.020E-1
1.000E0
 2 27
47 GO:0060251 regulation of glial cell proliferation 1.732E-3 3.992E-2
3.020E-1
1.000E0
 2 27
48 GO:0006457 protein folding 2.041E-3 4.202E-2
3.179E-1
1.000E0
 4 236
49 GO:0046722 lactic acid secretion 2.289E-3 4.202E-2
3.179E-1
1.000E0
 1 1
50 GO:1904209 positive regulation of chemokine (C-C motif) ligand 2 secretion 2.289E-3 4.202E-2
3.179E-1
1.000E0
 1 1
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 142 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030684 preribosome 1.806E-5 2.564E-3 1.420E-2 2.564E-3 4 70
2 GO:0032040 small-subunit processome 5.991E-5 3.469E-3 1.921E-2 8.507E-3 3 34
3 GO:0071204 histone pre-mRNA 3'end processing complex 7.329E-5 3.469E-3 1.921E-2 1.041E-2 2 6
4 GO:0000791 euchromatin 9.799E-5 3.479E-3 1.926E-2 1.391E-2 3 40
5 GO:0005832 chaperonin-containing T-complex 1.751E-4 4.974E-3 2.754E-2 2.487E-2 2 9
6 GO:0034399 nuclear periphery 2.412E-4 5.412E-3 2.997E-2 3.425E-2 4 136
7 GO:0002199 zona pellucida receptor complex 2.668E-4 5.412E-3 2.997E-2 3.789E-2 2 11
8 GO:0044452 nucleolar part 5.181E-4 9.196E-3
5.091E-2
7.357E-2
 3 70
9 GO:0005681 spliceosomal complex 6.005E-4 9.475E-3
5.246E-2
8.528E-2
 4 173
10 GO:0071013 catalytic step 2 spliceosome 1.078E-3 1.530E-2
8.469E-2
1.530E-1
 3 90
11 GO:0034708 methyltransferase complex 1.185E-3 1.530E-2
8.469E-2
1.683E-1
 3 93
12 GO:0005689 U12-type spliceosomal complex 1.543E-3 1.826E-2
1.011E-1
2.191E-1
 2 26
13 GO:0016363 nuclear matrix 1.726E-3 1.886E-2
1.044E-1
2.451E-1
 3 106
14 GO:0005719 nuclear euchromatin 2.054E-3 2.083E-2
1.153E-1
2.917E-1
 2 30
15 GO:0005874 microtubule 2.568E-3 2.431E-2
1.346E-1
3.647E-1
 5 427
16 GO:0034677 integrin alpha7-beta1 complex 4.481E-3 3.977E-2
2.202E-1
6.363E-1
 1 2
Show 11 more annotations

4: Human Phenotype [Display Chart] 207 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0002126 Polymicrogyria 6.397E-4 4.333E-2
2.562E-1
1.324E-1
 3 66
2 HP:0002891 Uterine leiomyosarcoma 2.128E-3 4.333E-2
2.562E-1
4.404E-1
 2 26
3 HP:0100954 Open operculum 2.721E-3 4.333E-2
2.562E-1
5.633E-1
 1 1
4 HP:0030253 Defective T cell proliferation 2.721E-3 4.333E-2
2.562E-1
5.633E-1
 1 1
5 HP:0005364 Severe viral infections 2.721E-3 4.333E-2
2.562E-1
5.633E-1
 1 1
6 HP:0007620 Cutaneous leiomyoma 2.721E-3 4.333E-2
2.562E-1
5.633E-1
 1 1
7 HP:0003536 Decreased fumarate hydratase activity 2.721E-3 4.333E-2
2.562E-1
5.633E-1
 1 1
8 HP:0007437 Multiple cutaneous leiomyomas 2.721E-3 4.333E-2
2.562E-1
5.633E-1
 1 1
9 HP:0030080 Burkitt lymphoma 2.721E-3 4.333E-2
2.562E-1
5.633E-1
 1 1
10 HP:0006593 Anomalous rib insertion to vertebrae 2.721E-3 4.333E-2
2.562E-1
5.633E-1
 1 1
11 HP:0006755 Cutaneous leiomyosarcoma 2.721E-3 4.333E-2
2.562E-1
5.633E-1
 1 1
12 HP:0004695 Calcaneal epiphyseal stippling 2.721E-3 4.333E-2
2.562E-1
5.633E-1
 1 1
13 HP:0006768 Localized neuroblastoma 2.721E-3 4.333E-2
2.562E-1
5.633E-1
 1 1
Show 8 more annotations

5: Mouse Phenotype [Display Chart] 513 annotations before applied cutoff / 9299 genes in category

No results to display

6: Domain [Display Chart] 328 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR003307 W2 domain InterPro 1.073E-4 7.507E-3 4.783E-2 3.518E-2 2 7
2 PF02020 W2 Pfam 1.073E-4 7.507E-3 4.783E-2 3.518E-2 2 7
3 SM00515 eIF5C SMART 1.073E-4 7.507E-3 4.783E-2 3.518E-2 2 7
4 PS51363 W2 PROSITE 1.073E-4 7.507E-3 4.783E-2 3.518E-2 2 7
5 IPR002194 Chaperonin TCP-1 CS InterPro 1.834E-4 7.507E-3 4.783E-2
6.014E-2
 2 9
6 IPR001844 Chaprnin Cpn60 InterPro 1.834E-4 7.507E-3 4.783E-2
6.014E-2
 2 9
7 PS00750 TCP1 1 PROSITE 2.289E-4 7.507E-3 4.783E-2
7.507E-2
 2 10
8 PS00995 TCP1 3 PROSITE 2.289E-4 7.507E-3 4.783E-2
7.507E-2
 2 10
9 PS00751 TCP1 2 PROSITE 2.289E-4 7.507E-3 4.783E-2
7.507E-2
 2 10
10 IPR017998 Chaperone TCP-1 InterPro 2.289E-4 7.507E-3 4.783E-2
7.507E-2
 2 10
11 IPR027410 TCP-1-like intermed InterPro 2.793E-4 7.635E-3 4.865E-2
9.161E-2
 2 11
12 3.30.260.10 - Gene3D 2.793E-4 7.635E-3 4.865E-2
9.161E-2
 2 11
13 IPR027413 GROEL-like equatorial InterPro 4.601E-4 8.694E-3
5.540E-2
1.509E-1
 2 14
14 1.10.560.10 - Gene3D 4.601E-4 8.694E-3
5.540E-2
1.509E-1
 2 14
15 3.50.7.10 - Gene3D 5.301E-4 8.694E-3
5.540E-2
1.739E-1
 2 15
16 IPR027409 GroEL-like apical dom InterPro 5.301E-4 8.694E-3
5.540E-2
1.739E-1
 2 15
17 PF00118 Cpn60 TCP1 Pfam 5.301E-4 8.694E-3
5.540E-2
1.739E-1
 2 15
18 1.25.40.180 - Gene3D 5.301E-4 8.694E-3
5.540E-2
1.739E-1
 2 15
19 IPR002423 Cpn60/TCP-1 InterPro 5.301E-4 8.694E-3
5.540E-2
1.739E-1
 2 15
20 IPR016021 MIF4-like InterPro 5.301E-4 8.694E-3
5.540E-2
1.739E-1
 2 15
21 PF02344 Myc-LZ Pfam 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
22 IPR005677 Fum hydII InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
23 IPR024667 HnRNP M InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
24 IPR011430 DRIM InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
25 IPR025763 Trm8 euk InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
26 PF11532 HnRNP M Pfam 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
27 IPR017198 DNMT1 meta InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
28 PF12328 Rpp20 Pfam 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
29 IPR030668 Spermi synthase euk InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
30 IPR032435 Band 7 C InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
31 IPR003358 tRNA (Gua-N-7) MeTrfase Trmb InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
32 PF16200 Band 7 C Pfam 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
33 PF09420 Nop16 Pfam 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
34 IPR022702 Cytosine MeTrfase1 RFD InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
35 PF07539 DRIM Pfam 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
36 PF12047 DNMT1-RFD Pfam 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
37 IPR014612 Pop7/Rpp20 InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
38 PF05890 Ebp2 Pfam 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
39 IPR008610 Ebp2 InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
40 IPR012718 Chap CCT epsi InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
41 PF08161 NUC173 Pfam 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
42 IPR019002 Ribosome biogenesis Nop16 InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
43 PF10415 FumaraseC C Pfam 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
44 IPR024666 HnRNP M PY-NLS InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
45 PS51625 SAM MT TRMB PROSITE 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
46 IPR018951 Fumarase C C InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
47 IPR012978 Uncharacterised NUC173 InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
48 IPR003327 Myc-LZ InterPro 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
49 PF02390 Methyltransf 4 Pfam 2.295E-3 1.536E-2
9.789E-2
7.528E-1
 1 1
50 3.40.50.150 - Gene3D 2.624E-3 1.709E-2
1.089E-1
8.606E-1
 3 120
Show 45 more annotations

7: Pathway [Display Chart] 313 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 169351 Validated targets of C-MYC transcriptional activation BioSystems: Pathway Interaction Database 1.410E-6 4.414E-4 2.792E-3 4.414E-4 5 81
2 106247 Association of TriC/CCT with target proteins during biosynthesis BioSystems: REACTOME 4.724E-5 5.469E-3 3.459E-2 1.479E-2 3 29
3 199378 Ribosome biogenesis in eukaryotes BioSystems: KEGG 5.242E-5 5.469E-3 3.459E-2 1.641E-2 4 85
4 106246 Folding of actin by CCT/TriC BioSystems: REACTOME 2.098E-4 1.532E-2
9.692E-2
6.568E-2
 2 9
5 106242 Chaperonin-mediated protein folding BioSystems: REACTOME 2.448E-4 1.532E-2
9.692E-2
7.662E-2
 3 50
6 106241 Protein folding BioSystems: REACTOME 3.250E-4 1.695E-2
1.072E-1
1.017E-1
 3 55
7 PW:0000076 pathway of urea cycle and metabolism of amino groups Pathway Ontology 4.519E-4 2.021E-2
1.278E-1
1.414E-1
 2 13
8 106193 Metabolism of polyamines BioSystems: REACTOME 6.065E-4 2.373E-2
1.501E-1
1.898E-1
 2 15
9 198758 Urea cycle and metabolism of amino groups BioSystems: WikiPathways 1.089E-3 3.443E-2
2.178E-1
3.409E-1
 2 20
10 PW:0000050 arginine and proline metabolic Pathway Ontology 1.202E-3 3.443E-2
2.178E-1
3.762E-1
 2 21
11 106245 Formation of tubulin folding intermediates by CCT/TriC BioSystems: REACTOME 1.320E-3 3.443E-2
2.178E-1
4.132E-1
 2 22
12 169344 C-MYC pathway BioSystems: Pathway Interaction Database 1.320E-3 3.443E-2
2.178E-1
4.132E-1
 2 22
13 106244 Prefoldin mediated transfer of substrate to CCT/TriC BioSystems: REACTOME 2.140E-3 4.733E-2
2.993E-1
6.700E-1
 2 28
14 106243 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding BioSystems: REACTOME 2.296E-3 4.733E-2
2.993E-1
7.185E-1
 2 29
15 142291 spermidine biosynthesis I BioSystems: BIOCYC 2.473E-3 4.733E-2
2.993E-1
7.742E-1
 1 1
16 105952 mRNA Splicing - Major Pathway BioSystems: REACTOME 2.570E-3 4.733E-2
2.993E-1
8.046E-1
 3 112
17 105951 mRNA Splicing BioSystems: REACTOME 2.570E-3 4.733E-2
2.993E-1
8.046E-1
 3 112
Show 12 more annotations

8: Pubmed [Display Chart] 5768 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15635413 Nucleolar proteome dynamics. Pubmed 3.354E-12 1.935E-8 1.787E-7 1.935E-8 10 419
2 20020773 Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. Pubmed 2.339E-11 6.744E-8 6.230E-7 1.349E-7 8 223
3 12429849 Functional proteomic analysis of human nucleolus. Pubmed 5.542E-10 8.750E-7 8.083E-6 3.196E-6 6 106
4 17314511 Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. Pubmed 7.566E-10 8.750E-7 8.083E-6 4.364E-6 7 210
5 25324306 hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. Pubmed 7.585E-10 8.750E-7 8.083E-6 4.375E-6 8 346
6 22751105 Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. Pubmed 6.398E-9 5.423E-6 5.010E-5 3.690E-5 6 159
7 23752268 The functional interactome landscape of the human histone deacetylase family. Pubmed 6.582E-9 5.423E-6 5.010E-5 3.796E-5 7 287
8 16196087 Large-scale analysis of the human ubiquitin-related proteome. Pubmed 1.195E-8 8.327E-6 7.692E-5 6.890E-5 7 313
9 25756610 DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. Pubmed 1.299E-8 8.327E-6 7.692E-5 7.494E-5 6 179
10 11790298 Directed proteomic analysis of the human nucleolus. Pubmed 3.175E-8 1.832E-5 1.692E-4 1.832E-4 6 208
11 17643375 Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Pubmed 5.365E-8 2.813E-5 2.599E-4 3.095E-4 7 390
12 25147182 Quantitative Lys-¿-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. Pubmed 6.481E-8 3.115E-5 2.878E-4 3.738E-4 7 401
13 21182205 Identification of proteins associated with ligand-activated estrogen receptor ¿ in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. Pubmed 8.367E-8 3.713E-5 3.429E-4 4.826E-4 6 245
14 23438482 Proteomic analysis of the NOS2 interactome in human airway epithelial cells. Pubmed 1.558E-7 6.421E-5 5.931E-4 8.989E-4 5 138
15 23349634 A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Pubmed 1.994E-7 7.667E-5 7.082E-4 1.150E-3 5 145
16 23383273 VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. Pubmed 2.166E-7 7.808E-5 7.212E-4 1.249E-3 6 288
17 22623428 Proteomic analysis of ¿4�1 integrin adhesion complexes reveals ¿-subunit-dependent protein recruitment. Pubmed 2.545E-7 8.634E-5 7.975E-4 1.468E-3 7 491
18 17620599 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Pubmed 3.796E-7 1.162E-4 1.073E-3 2.190E-3 6 317
19 23000965 Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Pubmed 3.901E-7 1.162E-4 1.073E-3 2.250E-3 5 166
20 16159877 Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin. Pubmed 4.390E-7 1.162E-4 1.073E-3 2.532E-3 5 170
21 25467444 Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. Pubmed 4.404E-7 1.162E-4 1.073E-3 2.540E-3 3 17
22 24816145 A COFRADIC protocol to study protein ubiquitination. Pubmed 4.519E-7 1.162E-4 1.073E-3 2.606E-3 5 171
23 23398456 The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. Pubmed 4.632E-7 1.162E-4 1.073E-3 2.672E-3 6 328
24 25693804 Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. Pubmed 4.971E-7 1.195E-4 1.104E-3 2.867E-3 6 332
25 26549023 The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. Pubmed 6.872E-7 1.234E-4 1.139E-3 3.964E-3 6 351
26 16236267 Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. Pubmed 7.367E-7 1.234E-4 1.139E-3 4.249E-3 4 78
27 25189999 Reversible epigenetic regulation of 14-3-3¿ expression in acquired gemcitabine resistance by uhrf1 and DNA methyltransferase 1. Pubmed 7.699E-7 1.234E-4 1.139E-3 4.441E-3 2 2
28 14525975:gr Regulation of alpha7 integrin expression during muscle differentiation. GeneRIF 7.699E-7 1.234E-4 1.139E-3 4.441E-3 2 2
29 22730407:gr Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway. GeneRIF 7.699E-7 1.234E-4 1.139E-3 4.441E-3 2 2
30 24481446 A positive feedback loop between EBP2 and c-Myc regulates rDNA transcription, cell proliferation, and tumorigenesis. Pubmed 7.699E-7 1.234E-4 1.139E-3 4.441E-3 2 2
31 25593313 Equol, an isoflavone metabolite, regulates cancer cell viability and protein synthesis initiation via c-Myc and eIF4G. Pubmed 7.699E-7 1.234E-4 1.139E-3 4.441E-3 2 2
32 15843384:gr Helicobacter pylori-induced macrophage apoptosis requires activation of ornithine decarboxylase by c-Myc. GeneRIF 7.699E-7 1.234E-4 1.139E-3 4.441E-3 2 2
33 17994007:gr The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. GeneRIF 7.699E-7 1.234E-4 1.139E-3 4.441E-3 2 2
34 17673620:gr UHRF1 plays a role in maintaining DNA methylation in mammalian cells. GeneRIF 7.699E-7 1.234E-4 1.139E-3 4.441E-3 2 2
35 21863248:gr Molecular characterizations of Nop16 in murine mammary tumors with varying levels of c-Myc. GeneRIF 7.699E-7 1.234E-4 1.139E-3 4.441E-3 2 2
36 23463006:gr UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9. GeneRIF 7.699E-7 1.234E-4 1.139E-3 4.441E-3 2 2
37 24778252 TRIM65 regulates microRNA activity by ubiquitination of TNRC6. Pubmed 8.488E-7 1.323E-4 1.222E-3 4.896E-3 6 364
38 25192599 Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. Pubmed 1.053E-6 1.557E-4 1.439E-3 6.074E-3 5 203
39 24244333 Profiling of Parkin-binding partners using tandem affinity purification. Pubmed 1.053E-6 1.557E-4 1.439E-3 6.074E-3 5 203
40 14532270 A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. Pubmed 1.143E-6 1.630E-4 1.506E-3 6.591E-3 3 23
41 21906983 Systematic and quantitative assessment of the ubiquitin-modified proteome. Pubmed 1.159E-6 1.630E-4 1.506E-3 6.685E-3 5 207
42 25144556 Autophagic degradation of the inhibitory p53 isoform ¿133p53¿ as a regulatory mechanism for p53-mediated senescence. Pubmed 1.197E-6 1.630E-4 1.506E-3 6.901E-3 4 88
43 21890473 A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Pubmed 1.215E-6 1.630E-4 1.506E-3 7.008E-3 5 209
44 16565220 Phosphoproteome analysis of the human mitotic spindle. Pubmed 1.244E-6 1.631E-4 1.506E-3 7.175E-3 5 210
45 9731529 Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. Pubmed 1.675E-6 2.146E-4 1.983E-3 9.659E-3 3 26
46 21139048 Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Pubmed 2.070E-6 2.372E-4 2.191E-3 1.194E-2 5 233
47 24637615 The DNMT1/PCNA/UHRF1 disruption induces tumorigenesis characterized by similar genetic and epigenetic signatures. Pubmed 2.308E-6 2.372E-4 2.191E-3 1.331E-2 2 3
48 22064703:gr S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance. GeneRIF 2.308E-6 2.372E-4 2.191E-3 1.331E-2 2 3
49 26178413 Bag-1 promotes cell survival through c-Myc-mediated ODC upregulation that is not preferred under apoptotic stimuli in MCF-7 cells. Pubmed 2.308E-6 2.372E-4 2.191E-3 1.331E-2 2 3
50 25207720 Luteolin induces apoptosis in BE colorectal cancer cells by downregulating calpain, UHRF1, and DNMT1 expressions. Pubmed 2.308E-6 2.372E-4 2.191E-3 1.331E-2 2 3
Show 45 more annotations

9: Interaction [Display Chart] 2324 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:FBL FBL interactions 8.671E-9 1.200E-5 9.997E-5 2.015E-5 9 233
2 int:SNU13 SNU13 interactions 1.033E-8 1.200E-5 9.997E-5 2.401E-5 8 164
3 int:NOP56 NOP56 interactions 1.834E-8 1.421E-5 1.184E-4 4.263E-5 9 254
4 int:VCAM1 VCAM1 interactions 2.055E-7 1.194E-4 9.942E-4 4.775E-4 10 447
5 int:NOP58 NOP58 interactions 3.114E-7 1.408E-4 1.173E-3 7.237E-4 6 104
6 int:SF3B3 SF3B3 interactions 3.635E-7 1.408E-4 1.173E-3 8.448E-4 7 175
7 int:SRPK3 SRPK3 interactions 5.623E-7 1.867E-4 1.555E-3 1.307E-3 5 61
8 int:SCARNA22 SCARNA22 interactions 6.578E-7 1.911E-4 1.591E-3 1.529E-3 6 118
9 int:RPS6KB2 RPS6KB2 interactions 8.364E-7 2.160E-4 1.799E-3 1.944E-3 7 198
10 int:SSR1 SSR1 interactions 1.124E-6 2.509E-4 2.090E-3 2.612E-3 5 70
11 int:TARDBP TARDBP interactions 1.188E-6 2.509E-4 2.090E-3 2.760E-3 8 304
12 int:RFC4 RFC4 interactions 2.328E-6 4.509E-4 3.755E-3 5.411E-3 5 81
13 int:PES1 PES1 interactions 4.613E-6 8.246E-4 6.868E-3 1.072E-2 5 93
14 int:DDX18 DDX18 interactions 7.618E-6 1.226E-3 1.021E-2 1.770E-2 5 103
15 int:DHX15 DHX15 interactions 7.916E-6 1.226E-3 1.021E-2 1.840E-2 6 181
16 int:PRKRA PRKRA interactions 1.076E-5 1.563E-3 1.302E-2 2.500E-2 4 52
17 int:NAT10 NAT10 interactions 1.667E-5 2.278E-3 1.898E-2 3.873E-2 4 58
18 int:DDX24 DDX24 interactions 2.110E-5 2.725E-3 2.269E-2 4.905E-2 5 127
19 int:PACRG PACRG interactions 2.262E-5 2.766E-3 2.304E-2
5.256E-2
 3 21
20 int:ILK ILK interactions 2.399E-5 2.788E-3 2.322E-2
5.575E-2
 6 220
21 int:HDAC11 HDAC11 interactions 2.734E-5 2.805E-3 2.336E-2
6.353E-2
 5 134
22 int:RPL10 RPL10 interactions 2.751E-5 2.805E-3 2.336E-2
6.394E-2
 7 337
23 int:SRRM2 SRRM2 interactions 2.861E-5 2.805E-3 2.336E-2
6.649E-2
 6 227
24 int:DHX9 DHX9 interactions 3.080E-5 2.805E-3 2.336E-2
7.158E-2
 6 230
25 int:PUM3 PUM3 interactions 3.138E-5 2.805E-3 2.336E-2
7.292E-2
 4 68
26 int:AIRE AIRE interactions 3.138E-5 2.805E-3 2.336E-2
7.292E-2
 4 68
27 int:TRIM28 TRIM28 interactions 3.393E-5 2.898E-3 2.413E-2
7.885E-2
 6 234
28 int:EFTUD2 EFTUD2 interactions 3.491E-5 2.898E-3 2.413E-2
8.113E-2
 5 141
29 int:U2AF2 U2AF2 interactions 3.973E-5 3.184E-3 2.652E-2
9.234E-2
 7 357
30 int:KAT5 KAT5 interactions 4.909E-5 3.687E-3 3.071E-2
1.141E-1
 6 250
31 int:DCAF13 DCAF13 interactions 4.919E-5 3.687E-3 3.071E-2
1.143E-1
 3 27
32 int:CRY2 CRY2 interactions 5.159E-5 3.747E-3 3.120E-2
1.199E-1
 5 153
33 int:NOS2 NOS2 interactions 5.488E-5 3.844E-3 3.201E-2
1.275E-1
 5 155
34 int:ASS1 ASS1 interactions 5.667E-5 3.844E-3 3.201E-2
1.317E-1
 4 79
35 int:STK24 STK24 interactions 5.954E-5 3.844E-3 3.201E-2
1.384E-1
 4 80
36 int:SUMO4 SUMO4 interactions 5.954E-5 3.844E-3 3.201E-2
1.384E-1
 4 80
37 int:ZNF121 ZNF121 interactions 6.886E-5 4.325E-3 3.602E-2
1.600E-1
 2 5
38 int:DDX56 DDX56 interactions 7.549E-5 4.617E-3 3.845E-2
1.754E-1
 4 85
39 int:NOC3L NOC3L interactions 9.073E-5 5.407E-3 4.503E-2
2.109E-1
 3 33
40 int:PRR11 PRR11 interactions 9.850E-5 5.723E-3 4.766E-2
2.289E-1
 4 91
41 int:IQCB1 IQCB1 interactions 1.246E-4 6.845E-3
5.701E-2
2.897E-1
 6 296
42 int:WDR77 WDR77 interactions 1.262E-4 6.845E-3
5.701E-2
2.933E-1
 4 97
43 int:MATR3 MATR3 interactions 1.267E-4 6.845E-3
5.701E-2
2.943E-1
 5 185
44 int:DKC1 DKC1 interactions 1.313E-4 6.937E-3
5.778E-2
3.052E-1
 4 98
45 int:CCT2 CCT2 interactions 1.435E-4 7.128E-3
5.937E-2
3.335E-1
 5 190
46 int:SYT9 SYT9 interactions 1.441E-4 7.128E-3
5.937E-2
3.349E-1
 2 7
47 int:HNRNPA0 HNRNPA0 interactions 1.476E-4 7.128E-3
5.937E-2
3.430E-1
 4 101
48 int:MPHOSPH10 MPHOSPH10 interactions 1.503E-4 7.128E-3
5.937E-2
3.493E-1
 3 39
49 int:NOL6 NOL6 interactions 1.503E-4 7.128E-3
5.937E-2
3.493E-1
 3 39
50 int:PRPF40A PRPF40A interactions 1.544E-4 7.178E-3
5.978E-2
3.589E-1
 5 193
Show 45 more annotations

10: Cytoband [Display Chart] 41 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3q28 3q28 7.482E-4 1.774E-2
7.635E-2
 3.068E-2 2 31
2 1p35-p33 1p35-p33 1.298E-3 1.774E-2
7.635E-2
5.323E-2
 1 1
3 1p36-p22 1p36-p22 1.298E-3 1.774E-2
7.635E-2
5.323E-2
 1 1
4 6p21.33 6p21.33 2.018E-3 2.069E-2
8.901E-2
8.274E-2
 2 51
5 12q13 12q13 3.869E-3 3.173E-2
1.365E-1
1.586E-1
 2 71
6 20p13 20p13 7.818E-3 4.640E-2
1.997E-1
3.205E-1
 2 102
7 12q23 12q23 9.053E-3 4.640E-2
1.997E-1
3.712E-1
 1 7
8 6q14-q15 6q14-q15 9.053E-3 4.640E-2
1.997E-1
3.712E-1
 1 7
Show 3 more annotations

11: Transcription Factor Binding Site [Display Chart] 298 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 27 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 587 Chaperonins genenames.org 1.883E-4 5.083E-3 1.978E-2 5.083E-3 2 15
2 725 RNA binding motif containing genenames.org 3.009E-3 3.705E-2
1.442E-1
8.124E-2
 3 213
3 810 ATP binding cassette subfamily F genenames.org 4.117E-3 3.705E-2
1.442E-1
1.112E-1
 1 3

13: Coexpression [Display Chart] 3161 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13936 Genes down-regulated in BJAB cells (B-lymphoma) after glutamine [PubChem=738] deprivation. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.217E-19 3.847E-16 3.323E-15 3.847E-16 17 337
2 M18854 Genes down-regulated in BJUB cells (B-lymphoma) in response to rapamycin [PubChem=6610346] treatment. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.299E-14 1.312E-10 1.133E-9 2.623E-10 12 245
3 M5928 A subgroup of genes regulated by MYC - version 2 (v2). MSigDB H: Hallmark Gene Sets (v5.1) 3.575E-13 3.767E-10 3.253E-9 1.130E-9 8 58
4 GSE21670 UNTREATED VS IL6 TREATED STAT3 KO CD4 TCELL DN Genes down-regulated in CD4 [GeneID=920] T cells with STAT3 [GeneID=6774] knockout: medium versus IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v5.1) 8.611E-12 6.805E-9 5.877E-8 2.722E-8 10 197
5 M2069 Genes selected in supervised analyses to discriminate cells expressing c-Myc [GeneID=4609] from control cells expressing GFP. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.342E-11 8.482E-9 7.325E-8 4.241E-8 10 206
6 M2080 Genes up-regulated by TGFB1 [GeneID=7040] in MEF cells (embryonic fibroblast) via TGFB1R [GeneID=7046]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.246E-10 8.432E-8 7.282E-7 7.101E-7 8 127
7 M1447 Genes defining proliferation and self renewal potential of the bipotential myeloid cell line FDB. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.547E-10 8.432E-8 7.282E-7 8.050E-7 8 129
8 GSE21670 STAT3 KO VS WT CD4 TCELL DN Genes down-regulated in CD4 [GeneID=920] T cells: STAT3 [GeneID=6774] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v5.1) 2.689E-10 8.432E-8 7.282E-7 8.499E-7 9 197
9 M5925 Genes encoding cell cycle related targets of E2F transcription factors. MSigDB H: Hallmark Gene Sets (v5.1) 3.075E-10 8.432E-8 7.282E-7 9.721E-7 9 200
10 M5926 A subgroup of genes regulated by MYC - version 1 (v1). MSigDB H: Hallmark Gene Sets (v5.1) 3.075E-10 8.432E-8 7.282E-7 9.721E-7 9 200
11 GSE40274 XBP1 VS FOXP3 AND XBP1 TRANSDUCED ACTIVATED CD4 TCELL DN Genes down-regulated in CD4 T conv over-expressing XBP1 [GeneID=7494] versus XBP1 and FOX3P [GeneID=7494;50943]. MSigDB C7: Immunologic Signatures (v5.1) 3.075E-10 8.432E-8 7.282E-7 9.721E-7 9 200
12 M12243 Genes up-regulated in P493-6 cells (Burkitt's lymphoma) induced to express MYC [GeneID=4609]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.201E-10 8.432E-8 7.282E-7 1.012E-6 7 80
13 M18562 Genes down-regulated in response to both hypoxia and overexpression of an active form of HIF1A [GeneID=3091]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.729E-10 9.067E-8 7.830E-7 1.179E-6 10 289
14 M7079 The 'core ESC-like gene module': genes coordinately up-regulated in a compendium of mouse embryonic stem cells (ESC) which are shared with the human ESC-like module. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.557E-9 3.516E-7 3.036E-6 4.922E-6 10 335
15 M2132 Genes down-regulated in RS4;11 cells (MLL, mixed lineage leukemia) in response to SB216763 [PubChemID=176158], an inhibitor of GSK3B [GeneID=2932]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.479E-9 9.438E-7 8.151E-6 1.416E-5 10 374
16 M12104 Genes down-regulated in BJAB cells (B-lymphoma) after leucine [PubChem=857] deprivation. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.866E-9 9.613E-7 8.302E-6 1.538E-5 8 187
17 M11891 The postradiation tumor escape signature: genes up-regulated in tumors from irradiated stroma vs those from non-irradiated stroma. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.185E-9 1.133E-6 9.787E-6 2.271E-5 10 393
18 GSE28726 NAIVE CD4 TCELL VS NAIVE NKTCELL UP Genes up-regulated in naïve T cells: CD4 [GeneID=920] versus NK. MSigDB C7: Immunologic Signatures (v5.1) 8.246E-9 1.133E-6 9.787E-6 2.606E-5 8 200
19 M6555 Genes up-regulated in monocyte-derived dendritic cells: untreated versus AM580 [PubChem=2126]. MSigDB C7: Immunologic Signatures (v5.1) 8.246E-9 1.133E-6 9.787E-6 2.606E-5 8 200
20 M4533 Genes down-regulated in comparison of unstimulated NK cells versus those stimulated with IL2 [GeneID=3600] at 16 h. MSigDB C7: Immunologic Signatures (v5.1) 8.246E-9 1.133E-6 9.787E-6 2.606E-5 8 200
21 M4531 Genes down-regulated in comparison of unstimulated NK cells versus those stimulated with IL2 [GeneID=3558] at 16 h. MSigDB C7: Immunologic Signatures (v5.1) 8.246E-9 1.133E-6 9.787E-6 2.606E-5 8 200
22 GSE30971 WBP7 HET VS KO MACROPHAGE 4H LPS STIM UP Genes up-regulated in bone marrow-derived macrophages treated with LPS for 4h: heterozygous versus homozygous knockout of MLL4 [GeneID=9757]. MSigDB C7: Immunologic Signatures (v5.1) 8.246E-9 1.133E-6 9.787E-6 2.606E-5 8 200
23 M4599 Genes up-regulated in comparison of CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 3 versus CD25- T cells incubated with IL4 [GeneID=3565] at day 3. MSigDB C7: Immunologic Signatures (v5.1) 8.246E-9 1.133E-6 9.787E-6 2.606E-5 8 200
24 M13893 Genes down-regulated in Daudi cells (B lymphocytes) stably expressing CD5 [GeneID=921] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.725E-8 2.272E-6 1.962E-5 5.452E-5 10 431
25 M16033 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 8. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.859E-8 7.341E-6 6.340E-5 1.852E-4 5 49
26 M6822 Genes down-regulated in HMLE cells (mmortalized nontransformed mammary epithelial) by expression of a dominant-negative form of E-cadhedrin (CDH1) [GeneID=999]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.039E-8 7.341E-6 6.340E-5 1.909E-4 7 169
27 M7987 Genes highly expressed in hepatocellular carcinoma with poor survival. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.670E-8 8.980E-6 7.755E-5 2.425E-4 7 175
28 GSE22611 NOD2 TRANSDUCED VS CTRL HEK293T STIMULATED WITH MDP 2H DN Genes down-regulated in HEK293 cells at 2h after stimulation by muramyl dipeptide [PubChem=11620162]: over-expressing wildtype NOD2 [GeneID=64127] versus control. MSigDB C7: Immunologic Signatures (v5.1) 9.301E-8 1.050E-5 9.068E-5 2.940E-4 7 180
29 M16975 Up-regulated genes in peripheral zone of human pancreatic cancer growing in the pancreas of nude mice compared to that of the tumor from the central zone. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.248E-7 1.360E-5 1.175E-4 3.945E-4 8 284
30 GSE23321 EFFECTOR MEMORY VS NAIVE CD8 TCELL DN Genes down-regulated in CD8 T cells: effector memory versus naïve. MSigDB C7: Immunologic Signatures (v5.1) 1.781E-7 1.629E-5 1.407E-4 5.631E-4 7 198
31 GSE26156 DOUBLE POSITIVE VS CD4 SINGLE POSITIVE THYMOCYTE DN Genes down-regulated in thymocytes: double positive versus CD4 [GeneID=920] single positive. MSigDB C7: Immunologic Signatures (v5.1) 1.843E-7 1.629E-5 1.407E-4 5.827E-4 7 199
32 M5296 Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from old donors versus those treated with TSST at 16 h. MSigDB C7: Immunologic Signatures (v5.1) 1.907E-7 1.629E-5 1.407E-4 6.029E-4 7 200
33 GSE23114 PERITONEAL CAVITY B1A BCELL VS SPLEEN BCELL DN Genes down-regulated in B lymphocytes from: peritoneal cavity versus spleen. MSigDB C7: Immunologic Signatures (v5.1) 1.907E-7 1.629E-5 1.407E-4 6.029E-4 7 200
34 GSE23114 WT VS SLE2C1 MOUSE SPLEEN B1A BCELL UP Genes up-regulated in spleen B lymphocytes: wildtype versus lupus susceptibility locus Sle2c1. MSigDB C7: Immunologic Signatures (v5.1) 1.907E-7 1.629E-5 1.407E-4 6.029E-4 7 200
35 GSE37532 TREG VS TCONV CD4 TCELL FROM LN UP Genes up-regulated in lymph node from aged mice: T reg versus T conv. MSigDB C7: Immunologic Signatures (v5.1) 1.907E-7 1.629E-5 1.407E-4 6.029E-4 7 200
36 GSE28726 NAIVE VS ACTIVATED VA24NEG NKTCELL UP Genes up-regulated in Va24- NKT cells: naïve versus activated. MSigDB C7: Immunologic Signatures (v5.1) 1.907E-7 1.629E-5 1.407E-4 6.029E-4 7 200
37 GSE28726 NAIVE VS ACTIVATED CD4 TCELL DN Genes down-regulated in CD4 [GeneID=920] T cells: naïve versus activated. MSigDB C7: Immunologic Signatures (v5.1) 1.907E-7 1.629E-5 1.407E-4 6.029E-4 7 200
38 M18855 Up-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.249E-7 1.871E-5 1.616E-4 7.109E-4 9 428
39 M1319 Genes up-regulated in hematopoietic precursor cells conditionally expressing HOXA9 and MEIS1 [GeneID=3205;4211]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.475E-7 2.006E-5 1.733E-4 7.824E-4 5 65
40 M5042 Up-regulated genes in the canonical gene expression signature of the fibroblast core serum response (CSR) defined by the Stanford group. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.832E-7 2.224E-5 1.921E-4 8.951E-4 7 212
41 M17905 Genes up-regulated in MCF7 cells (breast cancer) after knockdown of HIF1A [GeneID=3091] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.885E-7 2.224E-5 1.921E-4 9.120E-4 5 67
42 M1571 Genes down-regulated in embryonic stem cells from TCEB3 [GeneID=6924] knockout mice. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.114E-7 2.344E-5 2.024E-4 9.843E-4 7 215
43 M2510 Genes down-regulated in HL-60 cells (promyeloid leukemia) by cantharidin [PubChem=6708701]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.347E-7 2.460E-5 2.125E-4 1.058E-3 5 69
44 M6506 Genes up-regulated by MYC [GeneID=4609] and whose promoters are bound by MYC, according to MYC Target Gene Database. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.316E-7 3.734E-5 3.225E-4 1.680E-3 6 143
45 M10633 Genes which comprise the top 1% of highly interconnected genes (major hubs) that account for most of gene interactions in the reconstructed regulatory networks from expression profiles in B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.316E-7 3.734E-5 3.225E-4 1.680E-3 6 143
46 M16010 Genes down-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.824E-7 6.063E-5 5.236E-4 2.789E-3 7 251
47 M2394 Genes down-regulated in 745A cells (erythroleukemia) upon knockdown of FLI1 [GeneID=2313] by RNAi and down-regulation of SPI1 [GeneID=6688] by HMBA [PubChemID=3616]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.413E-6 9.502E-5 8.206E-4 4.466E-3 5 92
48 GSE33292 DN3 THYMOCYTE VS TCELL LYMPHOMA FROM TCF1 KO UP Genes up-regulated in TCF7 [GeneID=6932] knockout: DN3 thymocytes versus T cell lymphoma cells. MSigDB C7: Immunologic Signatures (v5.1) 1.463E-6 9.635E-5 8.321E-4 4.625E-3 6 170
49 M6328 Genes down-regulated in spleen from wildtype mice: control versus LPS. MSigDB C7: Immunologic Signatures (v5.1) 1.620E-6 1.045E-4 9.024E-4 5.120E-3 6 173
50 M1915 Genes down-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.702E-6 1.076E-4 9.294E-4 5.381E-3 7 277
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 1128 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap dev gonad e11.5 M PrimGermCell Oct k4 1000 dev gonad e11.5 M PrimGermCell Oct k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.346E-8 1.982E-5 1.507E-4 2.646E-5 9 315
2 Lungmap Mouse e14.5 Epithelial (GSE52583) Top 500 All Mouse Lung E14.5 Epithelial top 500 Lungmap Mouse Single Cell (Lungmap.net) 3.514E-8 1.982E-5 1.507E-4 3.964E-5 10 446
3 gudmap dev gonad e12.5 M GermCellTestis Oct k1 1000 dev gonad e12.5 M GermCellTestis Oct k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 5.859E-7 1.733E-4 1.318E-3 6.609E-4 8 334
4 gudmap dev gonad e11.5 F PrimGermCell Oct k3 1000 dev gonad e11.5 F PrimGermCell Oct k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 6.146E-7 1.733E-4 1.318E-3 6.933E-4 9 463
5 gudmap kidney e10.5 UretericTip HoxB7 k4 1000 kidney e10.5 UretericTip HoxB7 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 7.982E-7 1.801E-4 1.370E-3 9.004E-4 8 348
6 gudmap kidney e10.5 UretericTrunk HoxB7 k2 1000 kidney e10.5 UretericTrunk HoxB7 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.936E-6 3.640E-4 2.768E-3 2.184E-3 7 271
7 gudmap dev gonad e13.5 M GermCell Oct 500 dev gonad e13.5 M GermCell Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.301E-5 3.708E-3 2.820E-2 2.596E-2 7 396
8 GSM791149 500 alpha beta T cells, preT.DN3B.Th, Lin-/lo CD25hi CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 3.010E-5 4.210E-3 3.202E-2 3.395E-2 7 413
9 Facebase RNAseq e10.5 Neural Epithelium Flanking Eminence 1000 K3 FacebaseRNAseq e10.5 Neural Epithelium Flanking Eminence top-relative-expression-ranked 1000 k-means-cluster#3 FaceBase_RNAseq 3.359E-5 4.210E-3 3.202E-2 3.789E-2 5 169
10 Facebase RNAseq e8.5 Hind Brain Neural Epithelium 1000 K4 FacebaseRNAseq e8.5 Hind Brain Neural Epithelium top-relative-expression-ranked 1000 k-means-cluster#4 FaceBase_RNAseq 6.181E-5 6.652E-3
5.059E-2
6.972E-2
 6 315
11 gudmap dev gonad e13.5 M GermCell Oct k3 500 dev gonad e13.5 M GermCell Oct k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.545E-5 6.652E-3
5.059E-2
7.383E-2
 4 99
12 gudmap dev gonad e11.5 F PrimGermCell Oct k1 500 dev gonad e11.5 F PrimGermCell Oct k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 7.076E-5 6.652E-3
5.059E-2
7.982E-2
 4 101
13 80Dn SubClass 80Dn 1 Top 500 Cluster 0 80Dn SubClass 80Dn 1 Top 500 Cluster 0 Brain Map - Allen iN 8.739E-5 7.041E-3
5.355E-2
9.857E-2
 7 489
14 80Dn SubClass 80Dn 1 Top 500 All 80Dn SubClass 80Dn 1 Top 500 All Brain Map - Allen iN 8.739E-5 7.041E-3
5.355E-2
9.857E-2
 7 489
15 gudmap dev gonad e11.5 F PrimGermCell Oct k3 200 dev gonad e11.5 F PrimGermCell Oct k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 1.146E-4 8.616E-3
6.553E-2
1.292E-1
 3 43
16 gudmap dev gonad e11.5 M PrimGermCell Oct k3 200 dev gonad e11.5 M PrimGermCell Oct k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 1.313E-4 9.259E-3
7.042E-2
1.481E-1
 3 45
17 gudmap dev gonad e11.5 M PrimGermCell Oct k2 500 dev gonad e11.5 M PrimGermCell Oct k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.472E-4 9.767E-3
7.429E-2
1.660E-1
 4 122
18 gudmap dev gonad e11.5 M PrimGermCell Oct 500 dev gonad e11.5 M PrimGermCell Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.630E-4 9.895E-3
7.526E-2
1.839E-1
 6 376
19 80Dp SubClass 80Dp 1 Top 500 Cluster 2 80Dp SubClass 80Dp 1 Top 500 Cluster 2 Brain Map - Allen iN 1.667E-4 9.895E-3
7.526E-2
1.880E-1
 4 126
20 gudmap dev gonad e12.5 M GermCellTestis Oct k3 500 dev gonad e12.5 M GermCellTestis Oct k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.771E-4 9.987E-3
7.596E-2
1.997E-1
 4 128
21 gudmap dev gonad e12.5 M GermCellTestis Oct 500 dev gonad e12.5 M GermCellTestis Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.906E-4 1.024E-2
7.786E-2
2.150E-1
 6 387
22 GSM791108 500 Stem Cells, SC.MEP.BM, Lineage- Kit+ Sca1- CD34- FcgR-/low, Bone marrow, avg-2 Immgen.org, GSE15907 2.308E-4 1.132E-2
8.611E-2
2.604E-1
 6 401
23 gudmap kidney P1 CapMes Crym k1 1000 kidney P1 CapMes Crym k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.308E-4 1.132E-2
8.611E-2
2.604E-1
 6 401
24 gudmap kidney e10.5 UretericTip HoxB7 k2 500 kidney e10.5 UretericTip HoxB7 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.429E-4 1.142E-2
8.682E-2
2.740E-1
 4 139
25 gudmap dev gonad e11.5 M PrimGermCell Oct k3 500 dev gonad e11.5 M PrimGermCell Oct k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.635E-4 1.189E-2
9.043E-2
2.972E-1
 4 142
26 GSM791131 500 B cells, MLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-3 Immgen.org, GSE15907 3.152E-4 1.368E-2
1.040E-1
3.556E-1
 6 425
27 Lungmap Mouse e16.5 Epithelial (GSE52583) Top 500 All Mouse Lung E16.5 Epithelial GSE52583 top 500 Lungmap Mouse Single Cell (Lungmap.net) 3.568E-4 1.455E-2
1.107E-1
4.025E-1
 6 435
28 Lungmap Mouse e16.5 Epithelial SubClass Proliferative AT1 Progenitor Top 500 All Mouse Lung E16.5 Epithelial Proliferative AT1 Progenitor top 500 Lungmap Mouse Single Cell (Lungmap.net) 3.612E-4 1.455E-2
1.107E-1
4.075E-1
 6 436
29 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 k1 1000 dev lower uro neuro e14.5 PelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 5.698E-4 2.216E-2
1.686E-1
6.428E-1
 5 310
30 Facebase RNAseq e9.5 Mandibular Arch 500 FacebaseRNAseq e9.5 Mandibular Arch top-relative-expression-ranked 500 FaceBase_RNAseq 6.406E-4 2.382E-2
1.812E-1
7.226E-1
 6 486
31 54Dn SubClass 54Dn 1 Top 500 Cluster 0 54Dn SubClass 54Dn 1 Top 500 Cluster 0 Brain Map - Allen iN 6.759E-4 2.382E-2
1.812E-1
7.624E-1
 6 491
32 54Dn SubClass 54Dn 1 Top 500 All 54Dn SubClass 54Dn 1 Top 500 All Brain Map - Allen iN 6.759E-4 2.382E-2
1.812E-1
7.624E-1
 6 491
33 12Dn Top 500 All 12Dn Top 500 All Brain Map - Allen iN 7.051E-4 2.410E-2
1.833E-1
7.954E-1
 6 495
34 gudmap kidney single cell e11.5 MetanephMesench Scamp 500 kidney single cell e11.5 MetanephMesench StemCellamp top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 8.525E-4 2.658E-2
2.022E-1
9.616E-1
 5 339
35 Facebase RNAseq e9.5 Mandibular Arch 500 K1 FacebaseRNAseq e9.5 Mandibular Arch top-relative-expression-ranked 500 k-means-cluster#1 FaceBase_RNAseq 8.712E-4 2.658E-2
2.022E-1
9.827E-1
 4 195
36 gudmap dev gonad e12.5 F GermCellOvary Oct k3 1000 dev gonad e12.5 F GermCellOvary Oct k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 8.712E-4 2.658E-2
2.022E-1
9.827E-1
 4 195
37 54Dp SubClass 54Dp 4 Top 500 Cluster 2 54Dp SubClass 54Dp 4 Top 500 Cluster 2 Brain Map - Allen iN 8.719E-4 2.658E-2
2.022E-1
9.835E-1
 2 20
38 gudmap kidney e15.5 SmlBldVes Tie2 k1 500 kidney e15.5 SmlBldVes Tie2 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.199E-4 2.731E-2
2.077E-1
1.000E0
 3 87
39 Lungmap Mouse e14.5 Epithelial (GSE52583) Top 500 Cluster 1 Mouse Lung E14.5 Epithelial top 500 c1 Lungmap Mouse Single Cell (Lungmap.net) 1.223E-3 3.537E-2
2.691E-1
1.000E0
 3 96
40 gudmap dev gonad e12.5 F VasAssMesen MafB k3 500 dev gonad e12.5 F VasAssMesen MafB k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.367E-3 3.855E-2
2.932E-1
1.000E0
 2 25
41 Facebase ST1 e9.5 FaceMesenchy 500 1 e9.5 FaceMesenchy top-relative-expression-ranked 500 1 FaceBase_ST1 1.431E-3 3.936E-2
2.994E-1
1.000E0
 4 223
42 gudmap kidney e10.5 UretericTip HoxB7 500 kidney e10.5 UretericTip HoxB7 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.483E-3 3.980E-2
3.027E-1
1.000E0
 5 384
43 gudmap dev gonad e11.5 F PrimGermCell Oct 500 dev gonad e11.5 F PrimGermCell Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.517E-3 3.980E-2
3.027E-1
1.000E0
 5 386
44 gudmap kidney e15.5 SmlBldVes Tie2 k3 1000 kidney e15.5 SmlBldVes Tie2 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.628E-3 4.173E-2
3.174E-1
1.000E0
 4 231
45 PCBC ratio SC-LF blastocyst vs SC blastocyst cfr-2X-p05 SC-LF blastocyst vs SC blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.697E-3 4.255E-2
3.236E-1
1.000E0
 5 396
46 GSM791129 500 B cells, MLP.BM, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Bone marrow, avg-2 Immgen.org, GSE15907 1.853E-3 4.383E-2
3.333E-1
1.000E0
 5 404
47 gudmap dev gonad e12.5 F GermCellOvary Oct 500 dev gonad e12.5 F GermCellOvary Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.893E-3 4.383E-2
3.333E-1
1.000E0
 5 406
48 GSM791119 500 Stem Cells, SC.GMP.BM, Lineage- sca1- ckithi CD34+ FcgRhi, Bone marrow, avg-3 Immgen.org, GSE15907 1.893E-3 4.383E-2
3.333E-1
1.000E0
 5 406
49 Lungmap Mouse e14.5 Epithelial (GSE52583) Top 500 Cluster 4 Mouse Lung E14.5 Epithelial top 500 c4 Lungmap Mouse Single Cell (Lungmap.net) 1.904E-3 4.383E-2
3.333E-1
1.000E0
 3 112
50 gudmap dev gonad e12.5 F GermCellOvary Oct k4 1000 dev gonad e12.5 F GermCellOvary Oct k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.988E-3 4.484E-2
3.411E-1
1.000E0
 4 244
Show 45 more annotations

15: Computational [Display Chart] 175 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 54 Genes in module 54 MSigDb: C4 - CM: Cancer Modules 7.174E-6 1.255E-3 7.212E-3 1.255E-3 7 245
2 MORF DNMT1 Neighborhood of DNMT1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.663E-5 1.455E-3 8.360E-3 2.910E-3 5 107
3 MORF EI24 Neighborhood of EI24 MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.675E-5 2.404E-3 1.381E-2 9.931E-3 5 138
4 MORF RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.874E-5 2.404E-3 1.381E-2 1.028E-2 5 139
5 GNF2 PA2G4 Neighborhood of PA2G4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.867E-5 2.404E-3 1.381E-2 1.202E-2 4 73
6 GNF2 RAN Neighborhood of RAN MSigDb: C4 - CGN: Cancer Gene Neighborhood 9.831E-5 2.867E-3 1.647E-2 1.720E-2 4 80
7 MORF RRM1 Neighborhood of RRM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.623E-4 3.719E-3 2.137E-2 2.840E-2 4 91
8 MORF PRKDC Neighborhood of PRKDC MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.700E-4 3.719E-3 2.137E-2 2.975E-2 5 174
9 module 61 Genes in module 61 MSigDb: C4 - CM: Cancer Modules 4.696E-4 9.131E-3
5.246E-2
8.218E-2
 3 50
10 MORF BUB1B Neighborhood of BUB1B MSigDb: C4 - CGN: Cancer Gene Neighborhood 8.428E-4 1.475E-2
8.474E-2
1.475E-1
 3 61
11 MORF BUB3 Neighborhood of BUB3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.074E-3 1.566E-2
8.996E-2
1.879E-1
 5 260
12 MORF HDAC2 Neighborhood of HDAC2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.074E-3 1.566E-2
8.996E-2
1.879E-1
 5 260
13 MORF PPP1CC Neighborhood of PPP1CC MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.168E-3 1.572E-2
9.031E-2
2.044E-1
 4 153
14 module 8 Genes in module 8 MSigDb: C4 - CM: Cancer Modules 1.275E-3 1.594E-2
9.158E-2
2.232E-1
 6 406
15 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 1.500E-3 1.750E-2
1.006E-1
2.625E-1
 6 419
16 module 18 Genes in module 18 MSigDb: C4 - CM: Cancer Modules 1.839E-3 1.973E-2
1.134E-1
3.218E-1
 6 436
17 module 126 Genes in module 126 MSigDb: C4 - CM: Cancer Modules 1.917E-3 1.973E-2
1.134E-1
3.354E-1
 4 175
18 MORF RAD54L Neighborhood of RAD54L MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.932E-3 2.851E-2
1.638E-1
5.131E-1
 3 94
19 module 15 Genes in module 15 MSigDb: C4 - CM: Cancer Modules 3.952E-3 3.587E-2
2.061E-1
6.917E-1
 5 350
20 module 17 Genes in module 17 MSigDb: C4 - CM: Cancer Modules 4.099E-3 3.587E-2
2.061E-1
7.173E-1
 5 353
21 MORF EIF3S2 Neighborhood of EIF3S2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.671E-3 3.893E-2
2.236E-1
8.175E-1
 4 224
Show 16 more annotations

16: MicroRNA [Display Chart] 567 annotations before applied cutoff / 19844 genes in category

No results to display

17: Drug [Display Chart] 7334 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1393 DN Nocodazole [31430-18-9]; Down 200; 13.2uM; HL60; HG-U133A Broad Institute CMAP 8.868E-19 6.504E-15 6.164E-14 6.504E-15 14 184
2 1598 DN Colchicine [64-86-8]; Down 200; 10uM; HL60; HG-U133A Broad Institute CMAP 2.829E-12 1.037E-8 9.831E-8 2.075E-8 10 178
3 3141 DN Dimaprit dihydrochloride [23256-33-9]; Down 200; 17uM; HL60; HT HG-U133A Broad Institute CMAP 1.212E-10 2.263E-7 2.145E-6 8.886E-7 9 182
4 1555 DN Clonidine hydrochloride [4205-91-8]; Down 200; 15uM; HL60; HG-U133A Broad Institute CMAP 1.471E-10 2.263E-7 2.145E-6 1.079E-6 9 186
5 6190 DN 15d-PGJ2; Down 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP 1.543E-10 2.263E-7 2.145E-6 1.132E-6 9 187
6 1607 DN Methylergometrine maleate [113-42-8]; Down 200; 8.8uM; HL60; HG-U133A Broad Institute CMAP 2.320E-9 2.836E-6 2.688E-5 1.702E-5 8 172
7 2136 DN Dihydroergotoxine mesylate [8067-24-1]; Down 200; 6.4uM; HL60; HT HG-U133A Broad Institute CMAP 3.470E-9 3.636E-6 3.446E-5 2.545E-5 8 181
8 1242 DN Rapamycin; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 7.311E-9 6.703E-6 6.353E-5 5.362E-5 8 199
9 2977 DN (-)-Quinpirole hydrochloride [85760-74-3]; Down 200; 15.6uM; HL60; HT HG-U133A Broad Institute CMAP 8.028E-8 5.346E-5 5.067E-4 5.888E-4 7 178
10 1398 DN Dihydroergotamine tartrate [5989-77-5]; Down 200; 3uM; HL60; HG-U133A Broad Institute CMAP 8.342E-8 5.346E-5 5.067E-4 6.118E-4 7 179
11 2007 DN Bromocryptine mesylate [22260-51-1]; Down 200; 5.4uM; HL60; HG-U133A Broad Institute CMAP 9.001E-8 5.346E-5 5.067E-4 6.601E-4 7 181
12 2338 DN Mebendazole [31431-39-7]; Down 200; 13.6uM; HL60; HT HG-U133A Broad Institute CMAP 1.045E-7 5.346E-5 5.067E-4 7.665E-4 7 185
13 1548 DN Retinoic acid [302-79-4]; Down 200; 13.4uM; HL60; HG-U133A Broad Institute CMAP 1.084E-7 5.346E-5 5.067E-4 7.952E-4 7 186
14 1177 DN LY 294002; Down 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP 1.166E-7 5.346E-5 5.067E-4 8.554E-4 7 188
15 1745 DN Dihydroergocristine mesylate [24730-10-7]; Down 200; 5.6uM; HL60; HG-U133A Broad Institute CMAP 1.166E-7 5.346E-5 5.067E-4 8.554E-4 7 188
16 1167 DN 17-AAG; Down 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP 1.166E-7 5.346E-5 5.067E-4 8.554E-4 7 188
17 6149 DN (-)-Isoproterenol hydrochloride [5984-95-2]; Down 200; 16.2uM; HL60; HT HG-U133A Broad Institute CMAP 1.299E-7 5.384E-5 5.103E-4 9.529E-4 7 191
18 1773 DN Chrysene-1,4-quinone [100900-16-1]; Down 200; 15.4uM; HL60; HG-U133A Broad Institute CMAP 1.395E-7 5.384E-5 5.103E-4 1.023E-3 7 193
19 1081 DN wortmannin from Penicillium funiculosum; Down 200; 0.01uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.395E-7 5.384E-5 5.103E-4 1.023E-3 7 193
20 1227 DN LY 294002; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 1.718E-7 6.300E-5 5.971E-4 1.260E-3 7 199
21 CID000100766 AdoDATO Stitch 7.029E-7 2.455E-4 2.327E-3 5.155E-3 3 9
22 2938 DN Alprostadil [745-65-3]; Down 200; 11.2uM; HL60; HT HG-U133A Broad Institute CMAP 1.630E-6 5.435E-4 5.151E-3 1.196E-2 6 175
23 1626 DN Etoposide [33419-42-0]; Down 200; 6.8uM; HL60; HG-U133A Broad Institute CMAP 1.920E-6 5.818E-4 5.514E-3 1.408E-2 6 180
24 2403 DN Pergolide mesylate [66104-23-2]; Down 200; 9.8uM; HL60; HT HG-U133A Broad Institute CMAP 1.983E-6 5.818E-4 5.514E-3 1.454E-2 6 181
25 1786 DN Chelidonine monohydrate (+) [476-32-4]; Down 200; 10.8uM; HL60; HG-U133A Broad Institute CMAP 1.983E-6 5.818E-4 5.514E-3 1.454E-2 6 181
26 1565 DN Ethacrynic acid [58-54-8]; Down 200; 13.2uM; HL60; HG-U133A Broad Institute CMAP 2.182E-6 6.154E-4 5.832E-3 1.600E-2 6 184
27 1016 DN LY 294002; Down 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 2.627E-6 7.136E-4 6.763E-3 1.927E-2 6 190
28 6166 DN 17-AAG; Down 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP 2.791E-6 7.245E-4 6.866E-3 2.047E-2 6 192
29 1221 DN Rapamycin; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 2.963E-6 7.245E-4 6.866E-3 2.173E-2 6 194
30 1547 DN Albendazole [54965-21-8]; Down 200; 15uM; HL60; HG-U133A Broad Institute CMAP 2.963E-6 7.245E-4 6.866E-3 2.173E-2 6 194
31 C061022 bullatacin CTD 4.239E-6 1.003E-3 9.505E-3 3.109E-2 2 2
32 C007262 deoxynivalenol CTD 4.682E-6 1.073E-3 1.017E-2 3.434E-2 8 465
33 CID011840990 DB08668 Stitch 1.014E-5 2.253E-3 2.135E-2
7.435E-2
 4 65
34 CID006439189 KYN-54 Stitch 1.270E-5 2.740E-3 2.596E-2
9.315E-2
 2 3
35 CID000018718 N-cyclohexyl-1,3-propanediamine Stitch 2.537E-5 5.168E-3 4.898E-2
1.860E-1
 2 4
36 CID009576807 MGBB Stitch 2.537E-5 5.168E-3 4.898E-2
1.860E-1
 2 4
37 7407 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 2.775E-5 5.500E-3
5.213E-2
2.035E-1
 5 171
38 2448 DN Puromycin dihydrochloride [58-58-2]; Down 200; 7.4uM; HL60; HT HG-U133A Broad Institute CMAP 2.934E-5 5.585E-3
5.293E-2
2.152E-1
 5 173
39 CID000012232 dimethyl disulfide Stitch 2.970E-5 5.585E-3
5.293E-2
2.178E-1
 3 29
40 C020735 dibutyldichlorotin CTD 3.295E-5 6.041E-3
5.725E-2
2.416E-1
 3 30
41 C025703 bleomycetin CTD 3.683E-5 6.046E-3
5.730E-2
2.701E-1
 4 90
42 1043 DN ICI 182,780; Down 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP 3.739E-5 6.046E-3
5.730E-2
2.742E-1
 5 182
43 CID000001078 AC1L1AOE Stitch 4.014E-5 6.046E-3
5.730E-2
2.944E-1
 3 32
44 1833 DN Azaguanine-8 [134-58-7]; Down 200; 26.2uM; HL60; HT HG-U133A Broad Institute CMAP 4.043E-5 6.046E-3
5.730E-2
2.965E-1
 5 185
45 2926 DN Zardaverine [101975-10-4]; Down 200; 15uM; HL60; HT HG-U133A Broad Institute CMAP 4.148E-5 6.046E-3
5.730E-2
3.042E-1
 5 186
46 CID000132581 RU 56187 Stitch 4.222E-5 6.046E-3
5.730E-2
3.097E-1
 2 5
47 CID004470983 AC1NBNXJ Stitch 4.222E-5 6.046E-3
5.730E-2
3.097E-1
 2 5
48 CID000124237 2,2-difluoroputrescine Stitch 4.222E-5 6.046E-3
5.730E-2
3.097E-1
 2 5
49 1421 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HG-U133A Broad Institute CMAP 4.365E-5 6.046E-3
5.730E-2
3.201E-1
 5 188
50 6170 DN retinoic acid; Down 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP 4.476E-5 6.046E-3
5.730E-2
3.283E-1
 5 189
Show 45 more annotations

18: Disease [Display Chart] 642 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0242656 Disease Progression DisGeNET Curated 2.424E-4 3.370E-2
2.374E-1
1.556E-1
 4 127
2 umls:C3280492 TUMOR PREDISPOSITION SYNDROME DisGeNET Curated 3.694E-4 3.370E-2
2.374E-1
2.371E-1
 2 12
3 umls:C0392077 Cardiac sarcoidosis DisGeNET BeFree 4.358E-4 3.370E-2
2.374E-1
2.798E-1
 2 13
4 umls:C0751569 Genitourinary Cancer DisGeNET BeFree 4.358E-4 3.370E-2
2.374E-1
2.798E-1
 2 13
5 umls:C0080032 Pleural Effusion, Malignant DisGeNET BeFree 6.110E-4 3.370E-2
2.374E-1
3.922E-1
 3 69
6 umls:C1511789 Desmoplastic DisGeNET BeFree 7.796E-4 3.370E-2
2.374E-1
5.005E-1
 3 75
7 umls:C1512409 Hepatocarcinogenesis DisGeNET BeFree 8.586E-4 3.370E-2
2.374E-1
5.513E-1
 6 471
8 umls:C1334455 Pulmonary Sclerosing Hemangioma DisGeNET BeFree 1.050E-3 3.370E-2
2.374E-1
6.743E-1
 2 20
9 umls:C0553580 Ewings sarcoma DisGeNET Curated 1.744E-3 3.370E-2
2.374E-1
1.000E0
 4 215
10 umls:C0013502 Echinococcosis DisGeNET Curated 1.780E-3 3.370E-2
2.374E-1
1.000E0
 2 26
11 umls:C1136085 Monoclonal Gammapathies DisGeNET BeFree 1.920E-3 3.370E-2
2.374E-1
1.000E0
 2 27
12 umls:C0740457 Malignant neoplasm of kidney DisGeNET BeFree 2.217E-3 3.370E-2
2.374E-1
1.000E0
 5 385
13 umls:C3824769 Lymphomas in children DisGeNET BeFree 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
14 cv:C0006413 Burkitt lymphoma Clinical Variations 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
15 umls:C3279885 Hereditary Sensory and Autonomic Neuropathy Type Ie DisGeNET Curated 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
16 cv:C2750786 Muscular dystrophy, congenital, due to integrin alpha-7 deficiency Clinical Variations 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
17 umls:C4014617 IMMUNODEFICIENCY 24 DisGeNET Curated 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
18 cv:C3280271 Parkinson disease 18 Clinical Variations 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
19 cv:C1850395 Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive Clinical Variations 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
20 umls:C4014283 CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 6 DisGeNET Curated 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
21 cv:CN078798 Spinocerebellar ataxia 36 Clinical Variations 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
22 cv:C0342770 Fumarase deficiency Clinical Variations 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
23 umls:C0004669 Bacteroides Infections DisGeNET BeFree 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
24 cv:C1858804 Cerebellar ataxia, deafness, and narcolepsy Clinical Variations 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
25 613204 MUSCULAR DYSTROPHY, CONGENITAL, DUE TO INTEGRIN ALPHA-7 DEFICIENCY OMIM 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
26 umls:C1314742 Skin atheroma DisGeNET BeFree 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
27 606812 FUMARASE DEFICIENCY OMIM 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
28 umls:C2750786 Muscular Dystrophy, Congenital, Due To Integrin Alpha-7 Deficiency DisGeNET Curated 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
29 cv:CN196688 Immunodeficiency 24 Clinical Variations 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
30 256840 NEUROPATHY, HEREDITARY SENSORY, WITH SPASTIC PARAPLEGIA, AUTOSOMAL RECESSIVE OMIM 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
31 umls:C0334385 Inflammatory carcinoma DisGeNET BeFree 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
32 cv:C0265342 Cerebro-costo-mandibular syndrome Clinical Variations 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
33 umls:C1332201 Adult Diffuse Large B-Cell Lymphoma DisGeNET BeFree 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
34 umls:C1850395 Neuropathy, Hereditary Sensory, with Spastic Paraplegia, Autosomal Recessive DisGeNET Curated 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
35 umls:C1265730 Progonoma DisGeNET BeFree 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
36 umls:C2936826 Fumaric aciduria DisGeNET Curated 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
37 cv:C3279885 NEUROPATHY, HEREDITARY SENSORY, TYPE IE Clinical Variations 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
38 umls:C1333063 Classical Burkitt Lymphoma DisGeNET BeFree 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
39 113970 BURKITT LYMPHOMA; BL OMIM 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
40 cv:CN186681 Cortical dysplasia, complex, with other brain malformations 6 Clinical Variations 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
41 cv:C0265245 Nager syndrome Clinical Variations 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
42 umls:C3280271 PARKINSON DISEASE 18 DisGeNET Curated 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
43 150800 LEIOMYOMA, HEREDITARY MULTIPLE, OF SKIN OMIM 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
44 umls:C0346172 Mucinous cystadenoma of ovary DisGeNET BeFree 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
45 umls:C3807295 CEREBELLAR ATAXIA, DEAFNESS, AND NARCOLEPSY, AUTOSOMAL DOMINANT DisGeNET Curated 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
46 605839 LEIOMYOMATOSIS AND RENAL CELL CANCER, HEREDITARY OMIM 2.415E-3 3.370E-2
2.374E-1
1.000E0
 1 1
47 umls:C1332225 Aggressive Non-Hodgkin Lymphoma DisGeNET BeFree 2.862E-3 3.909E-2
2.753E-1
1.000E0
 2 33
48 umls:C3536893 Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor DisGeNET BeFree 3.215E-3 4.300E-2
3.028E-1
1.000E0
 2 35
49 umls:C0032927 Precancerous Conditions DisGeNET Curated 3.329E-3 4.361E-2
3.071E-1
1.000E0
 5 423
50 umls:C0023486 Prolymphocytic Leukemia DisGeNET BeFree 4.183E-3 4.488E-2
3.161E-1
1.000E0
 2 40
Show 45 more annotations