Toppgene analysis for aggregated_1964_log, IC1, positive side

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1: GO: Molecular Function [Display Chart] 392 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008017 microtubule binding 1.899E-21 7.442E-19 4.874E-18 7.442E-19 27 214
2 GO:0015631 tubulin binding 6.463E-19 1.267E-16 8.297E-16 2.534E-16 28 293
3 GO:0003777 microtubule motor activity 1.416E-12 1.850E-10 1.212E-9 5.550E-10 13 77
4 GO:1990939 ATP-dependent microtubule motor activity 6.019E-10 5.899E-8 3.864E-7 2.360E-7 7 19
5 GO:0003774 motor activity 1.494E-9 1.172E-7 7.674E-7 5.858E-7 13 132
6 GO:0016887 ATPase activity 1.183E-8 7.727E-7 5.061E-6 4.636E-6 21 446
7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed 1.456E-8 8.155E-7 5.342E-6 5.709E-6 6 17
8 GO:0004674 protein serine/threonine kinase activity 2.629E-5 1.288E-3 8.436E-3 1.030E-2 16 452
9 GO:0035173 histone kinase activity 4.152E-5 1.808E-3 1.184E-2 1.628E-2 4 19
10 GO:0003697 single-stranded DNA binding 1.263E-4 4.426E-3 2.899E-2 4.949E-2 7 105
11 GO:0000217 DNA secondary structure binding 1.289E-4 4.426E-3 2.899E-2
5.054E-2
 4 25
12 GO:0042393 histone binding 1.355E-4 4.426E-3 2.899E-2
5.312E-2
 9 181
13 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor 3.315E-4 8.662E-3
5.673E-2
1.299E-1
 2 3
14 GO:0016728 oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor 3.315E-4 8.662E-3
5.673E-2
1.299E-1
 2 3
15 GO:0061731 ribonucleoside-diphosphate reductase activity 3.315E-4 8.662E-3
5.673E-2
1.299E-1
 2 3
16 GO:0043142 single-stranded DNA-dependent ATPase activity 3.890E-4 9.531E-3
6.243E-2
1.525E-1
 3 14
17 GO:0008094 DNA-dependent ATPase activity 4.606E-4 1.062E-2
6.957E-2
1.806E-1
 6 93
18 GO:0043515 kinetochore binding 6.583E-4 1.434E-2
9.390E-2
2.581E-1
 2 4
19 GO:0008301 DNA binding, bending 1.163E-3 2.399E-2
1.571E-1
4.558E-1
 3 20
20 GO:0010997 anaphase-promoting complex binding 1.623E-3 3.029E-2
1.984E-1
6.362E-1
 2 6
21 GO:0051880 G-quadruplex DNA binding 1.623E-3 3.029E-2
1.984E-1
6.362E-1
 2 6
22 GO:0030695 GTPase regulator activity 1.846E-3 3.289E-2
2.154E-1
7.236E-1
 10 312
23 GO:0000405 bubble DNA binding 2.256E-3 3.845E-2
2.519E-1
8.844E-1
 2 7
24 GO:0035174 histone serine kinase activity 2.987E-3 4.879E-2
3.196E-1
1.000E0
 2 8
Show 19 more annotations

2: GO: Biological Process [Display Chart] 1849 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007059 chromosome segregation 7.811E-84 1.444E-80 1.170E-79 1.444E-80 77 334
2 GO:0007067 mitotic nuclear division 2.625E-83 2.427E-80 1.966E-79 4.854E-80 84 455
3 GO:0098813 nuclear chromosome segregation 9.345E-80 5.760E-77 4.665E-76 1.728E-76 71 283
4 GO:0000819 sister chromatid segregation 6.450E-79 2.981E-76 2.415E-75 1.193E-75 66 225
5 GO:0000070 mitotic sister chromatid segregation 2.280E-52 8.430E-50 6.828E-49 4.215E-49 43 136
6 GO:0007062 sister chromatid cohesion 6.949E-47 2.142E-44 1.735E-43 1.285E-43 39 127
7 GO:0000226 microtubule cytoskeleton organization 1.838E-38 4.855E-36 3.933E-35 3.399E-35 52 465
8 GO:0051302 regulation of cell division 1.623E-30 3.751E-28 3.038E-27 3.001E-27 38 291
9 GO:0044839 cell cycle G2/M phase transition 3.392E-28 6.969E-26 5.645E-25 6.272E-25 32 206
10 GO:0000086 G2/M transition of mitotic cell cycle 1.646E-27 3.043E-25 2.465E-24 3.043E-24 31 197
11 GO:0051983 regulation of chromosome segregation 3.666E-26 6.163E-24 4.992E-23 6.779E-23 23 87
12 GO:0007051 spindle organization 1.781E-24 2.744E-22 2.223E-21 3.293E-21 26 148
13 GO:0007088 regulation of mitotic nuclear division 2.138E-24 3.041E-22 2.463E-21 3.953E-21 26 149
14 GO:0051783 regulation of nuclear division 1.127E-23 1.489E-21 1.206E-20 2.084E-20 27 177
15 GO:0007052 mitotic spindle organization 3.543E-22 4.367E-20 3.537E-19 6.551E-19 21 95
16 GO:0051304 chromosome separation 6.691E-22 7.732E-20 6.263E-19 1.237E-18 19 71
17 GO:0051303 establishment of chromosome localization 3.042E-21 3.309E-19 2.680E-18 5.625E-18 18 64
18 GO:0050000 chromosome localization 4.169E-21 4.282E-19 3.469E-18 7.708E-18 18 65
19 GO:0031577 spindle checkpoint 6.745E-21 6.564E-19 5.317E-18 1.247E-17 16 45
20 GO:0006323 DNA packaging 1.140E-20 1.054E-18 8.534E-18 2.107E-17 26 206
21 GO:0000075 cell cycle checkpoint 2.160E-20 1.902E-18 1.540E-17 3.993E-17 27 234
22 GO:0071103 DNA conformation change 2.654E-20 2.231E-18 1.807E-17 4.907E-17 29 285
23 GO:0010965 regulation of mitotic sister chromatid separation 1.013E-19 8.147E-18 6.599E-17 1.874E-16 16 52
24 GO:0070507 regulation of microtubule cytoskeleton organization 1.781E-19 1.372E-17 1.112E-16 3.293E-16 22 144
25 GO:0051306 mitotic sister chromatid separation 2.025E-19 1.498E-17 1.213E-16 3.745E-16 16 54
26 GO:0051310 metaphase plate congression 3.635E-19 2.558E-17 2.072E-16 6.721E-16 15 45
27 GO:0033045 regulation of sister chromatid segregation 3.735E-19 2.558E-17 2.072E-16 6.907E-16 17 68
28 GO:0032886 regulation of microtubule-based process 5.724E-19 3.780E-17 3.062E-16 1.058E-15 23 172
29 GO:0033047 regulation of mitotic sister chromatid segregation 7.398E-19 4.717E-17 3.821E-16 1.368E-15 16 58
30 GO:0007091 metaphase/anaphase transition of mitotic cell cycle 3.179E-18 1.960E-16 1.587E-15 5.879E-15 15 51
31 GO:0090068 positive regulation of cell cycle process 4.251E-18 2.491E-16 2.018E-15 7.859E-15 26 260
32 GO:0044784 metaphase/anaphase transition of cell cycle 4.427E-18 2.491E-16 2.018E-15 8.186E-15 15 52
33 GO:0000910 cytokinesis 4.446E-18 2.491E-16 2.018E-15 8.221E-15 21 146
34 GO:0051321 meiotic cell cycle 6.580E-18 3.578E-16 2.898E-15 1.217E-14 25 239
35 GO:0045787 positive regulation of cell cycle 1.120E-17 5.916E-16 4.792E-15 2.070E-14 29 355
36 GO:0008608 attachment of spindle microtubules to kinetochore 1.213E-17 6.230E-16 5.046E-15 2.243E-14 12 26
37 GO:1901987 regulation of cell cycle phase transition 3.463E-17 1.730E-15 1.402E-14 6.403E-14 28 340
38 GO:0007093 mitotic cell cycle checkpoint 3.988E-17 1.940E-15 1.572E-14 7.373E-14 21 162
39 GO:1901990 regulation of mitotic cell cycle phase transition 6.648E-17 3.152E-15 2.553E-14 1.229E-13 27 319
40 GO:0030071 regulation of mitotic metaphase/anaphase transition 6.893E-17 3.186E-15 2.581E-14 1.275E-13 14 49
41 GO:0010948 negative regulation of cell cycle process 8.882E-17 4.006E-15 3.244E-14 1.642E-13 24 240
42 GO:1902099 regulation of metaphase/anaphase transition of cell cycle 9.486E-17 4.176E-15 3.383E-14 1.754E-13 14 50
43 GO:0045786 negative regulation of cell cycle 9.745E-17 4.191E-15 3.394E-14 1.802E-13 32 484
44 GO:0033046 negative regulation of sister chromatid segregation 1.937E-16 8.138E-15 6.592E-14 3.581E-13 13 41
45 GO:0051985 negative regulation of chromosome segregation 3.947E-16 1.622E-14 1.313E-13 7.297E-13 13 43
46 GO:0030261 chromosome condensation 9.644E-16 3.877E-14 3.140E-13 1.783E-12 12 35
47 GO:2000816 negative regulation of mitotic sister chromatid separation 1.433E-15 5.639E-14 4.567E-13 2.650E-12 12 36
48 GO:0051782 negative regulation of cell division 1.821E-15 7.016E-14 5.683E-13 3.368E-12 15 75
49 GO:1903046 meiotic cell cycle process 2.038E-15 7.690E-14 6.229E-13 3.768E-12 21 196
50 GO:0007080 mitotic metaphase plate congression 2.102E-15 7.773E-14 6.296E-13 3.886E-12 12 37
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 220 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005819 spindle 1.833E-55 4.032E-53 2.408E-52 4.032E-53 57 308
2 GO:0000793 condensed chromosome 1.361E-54 1.497E-52 8.942E-52 2.994E-52 50 208
3 GO:0000775 chromosome, centromeric region 3.902E-54 2.861E-52 1.709E-51 8.584E-52 48 185
4 GO:0000779 condensed chromosome, centromeric region 3.924E-49 2.158E-47 1.289E-46 8.634E-47 38 105
5 GO:0098687 chromosomal region 6.101E-47 2.684E-45 1.603E-44 1.342E-44 53 345
6 GO:0000776 kinetochore 7.026E-46 2.576E-44 1.539E-43 1.546E-43 38 124
7 GO:0000777 condensed chromosome kinetochore 9.088E-44 2.856E-42 1.706E-41 1.999E-41 34 95
8 GO:0000922 spindle pole 1.983E-36 5.452E-35 3.257E-34 4.362E-34 33 133
9 GO:0005874 microtubule 1.076E-26 2.629E-25 1.570E-24 2.366E-24 40 427
10 GO:0072686 mitotic spindle 2.314E-26 5.091E-25 3.041E-24 5.091E-24 21 64
11 GO:0030496 midbody 1.984E-21 3.969E-20 2.371E-19 4.366E-19 23 137
12 GO:0000940 condensed chromosome outer kinetochore 9.244E-21 1.695E-19 1.012E-18 2.034E-18 11 13
13 GO:0005876 spindle microtubule 2.692E-20 4.556E-19 2.721E-18 5.922E-18 17 60
14 GO:0000794 condensed nuclear chromosome 8.058E-18 1.266E-16 7.564E-16 1.773E-15 18 97
15 GO:0000780 condensed nuclear chromosome, centromeric region 3.887E-17 5.701E-16 3.405E-15 8.552E-15 11 21
16 GO:0005871 kinesin complex 3.417E-16 4.699E-15 2.807E-14 7.518E-14 14 55
17 GO:0000778 condensed nuclear chromosome kinetochore 5.388E-15 6.972E-14 4.165E-13 1.185E-12 8 10
18 GO:0005875 microtubule associated complex 4.741E-14 5.795E-13 3.461E-12 1.043E-11 18 156
19 GO:0044450 microtubule organizing center part 2.653E-13 3.072E-12 1.835E-11 5.836E-11 17 148
20 GO:0051233 spindle midzone 3.051E-13 3.356E-12 2.005E-11 6.713E-11 10 30
21 GO:0000796 condensin complex 1.196E-12 1.253E-11 7.482E-11 2.631E-10 6 6
22 GO:0097431 mitotic spindle pole 3.904E-11 3.904E-10 2.332E-9 8.590E-9 7 14
23 GO:0005814 centriole 7.057E-11 6.750E-10 4.032E-9 1.553E-8 13 105
24 GO:0000785 chromatin 3.311E-10 3.035E-9 1.813E-8 7.285E-8 24 489
25 GO:0031262 Ndc80 complex 1.149E-8 9.726E-8 5.809E-7 2.529E-6 4 4
26 GO:0000942 condensed nuclear chromosome outer kinetochore 1.149E-8 9.726E-8 5.809E-7 2.529E-6 4 4
27 GO:0044815 DNA packaging complex 2.533E-8 2.064E-7 1.233E-6 5.572E-6 11 112
28 GO:0032133 chromosome passenger complex 5.700E-8 4.479E-7 2.675E-6 1.254E-5 4 5
29 GO:0031616 spindle pole centrosome 1.413E-7 1.072E-6 6.403E-6 3.109E-5 5 13
30 GO:1990752 microtubule end 3.720E-7 2.728E-6 1.629E-5 8.184E-5 6 28
31 GO:0010369 chromocenter 6.567E-7 4.661E-6 2.784E-5 1.445E-4 5 17
32 GO:0097149 centralspindlin complex 1.118E-6 7.689E-6 4.593E-5 2.461E-4 3 3
33 GO:0035371 microtubule plus-end 1.604E-6 1.069E-5 6.387E-5 3.529E-4 5 20
34 GO:0032153 cell division site 2.058E-6 1.276E-5 7.620E-5 4.527E-4 7 57
35 GO:0032155 cell division site part 2.058E-6 1.276E-5 7.620E-5 4.527E-4 7 57
36 GO:0045120 pronucleus 2.088E-6 1.276E-5 7.620E-5 4.593E-4 5 21
37 GO:0043073 germ cell nucleus 7.871E-6 4.680E-5 2.795E-4 1.732E-3 5 27
38 GO:0032154 cleavage furrow 1.151E-5 6.492E-5 3.878E-4 2.532E-3 6 49
39 GO:0097610 cell surface furrow 1.151E-5 6.492E-5 3.878E-4 2.532E-3 6 49
40 GO:0000790 nuclear chromatin 4.010E-5 2.205E-4 1.317E-3 8.821E-3 13 326
41 GO:0005881 cytoplasmic microtubule 4.954E-5 2.658E-4 1.588E-3 1.090E-2 6 63
42 GO:0072687 meiotic spindle 8.969E-5 4.698E-4 2.806E-3 1.973E-2 3 9
43 GO:0000799 nuclear condensin complex 1.083E-4 5.540E-4 3.309E-3 2.382E-2 2 2
44 GO:0097539 ciliary transition fiber 1.271E-4 6.357E-4 3.797E-3 2.797E-2 3 10
45 GO:1990023 mitotic spindle midzone 1.735E-4 8.481E-4 5.066E-3 3.817E-2 3 11
46 GO:0008278 cohesin complex 2.295E-4 1.074E-3 6.418E-3
5.050E-2
 3 12
47 GO:0070938 contractile ring 2.295E-4 1.074E-3 6.418E-3
5.050E-2
 3 12
48 GO:0042585 germinal vesicle 3.226E-4 1.446E-3 8.639E-3
7.098E-2
 2 3
49 GO:0005971 ribonucleoside-diphosphate reductase complex 3.226E-4 1.446E-3 8.639E-3
7.098E-2
 2 3
50 GO:0000803 sex chromosome 3.287E-4 1.446E-3 8.639E-3
7.232E-2
 4 32
Show 45 more annotations

4: Human Phenotype [Display Chart] 439 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0009879 Cortical gyral simplification 7.368E-11 2.511E-8 1.673E-7 3.235E-8 8 28
2 HP:0000340 Sloping forehead {has synonym type="layperson"} 1.144E-10 2.511E-8 1.673E-7 5.022E-8 9 44
3 HP:0002472 Small cerebral cortex 1.464E-5 2.142E-3 1.427E-2 6.426E-3 3 6
4 HP:0001321 Cerebellar hypoplasia 3.617E-5 3.180E-3 2.119E-2 1.588E-2 7 103
5 HP:0001511 Intrauterine growth retardation 3.622E-5 3.180E-3 2.119E-2 1.590E-2 9 185
6 HP:0003221 Chromosomal breakage induced by crosslinking agents 1.169E-4 8.554E-3
5.699E-2
5.132E-2
 3 11
7 HP:0001909 Leukemia 1.480E-4 9.283E-3
6.185E-2
6.498E-2
 4 30
8 HP:0000568 Microphthalmia 3.029E-4 1.660E-2
1.106E-1
1.330E-1
 7 144
9 HP:0000448 Prominent nose {has synonym type="layperson"} 3.403E-4 1.660E-2
1.106E-1
1.494E-1
 4 37
10 HP:0009778 Short thumb {has synonym type="layperson"} 5.080E-4 2.230E-2
1.486E-1
2.230E-1
 4 41
11 HP:0001620 High pitched voice {has synonym type="layperson"} 1.016E-3 4.056E-2
2.702E-1
4.461E-1
 3 22
12 HP:0001876 Pancytopenia 1.172E-3 4.173E-2
2.780E-1
5.146E-1
 4 51
13 HP:0006872 Cerebral hypoplasia 1.236E-3 4.173E-2
2.780E-1
5.424E-1
 2 6
14 HP:0003974 Absent radius 1.489E-3 4.549E-2
3.031E-1
6.535E-1
 3 25
15 HP:0000957 Cafe-au-lait spot 1.780E-3 4.549E-2
3.031E-1
7.814E-1
 4 57
16 HP:0002575 Tracheoesophageal fistula 1.869E-3 4.549E-2
3.031E-1
8.205E-1
 3 27
17 HP:0002667 Nephroblastoma 1.869E-3 4.549E-2
3.031E-1
8.205E-1
 3 27
18 HP:0001518 Small for gestational age {has synonym type="layperson"} 2.034E-3 4.549E-2
3.031E-1
8.929E-1
 5 99
19 HP:0000238 Hydrocephalus 2.123E-3 4.549E-2
3.031E-1
9.319E-1
 6 147
20 HP:0003213 Deficient excision of UV-induced pyrimidine dimers in DNA 2.279E-3 4.549E-2
3.031E-1
1.000E0
 2 8
21 HP:0003214 Prolonged G2 phase of cell cycle 2.279E-3 4.549E-2
3.031E-1
1.000E0
 2 8
22 HP:0001017 Anemic pallor 2.279E-3 4.549E-2
3.031E-1
1.000E0
 2 8
23 HP:0000085 Horseshoe kidney {has synonym type="layperson"} 2.799E-3 4.698E-2
3.130E-1
1.000E0
 3 31
24 HP:0002032 Esophageal atresia 2.799E-3 4.698E-2
3.130E-1
1.000E0
 3 31
25 HP:0006989 Dysplastic corpus callosum 2.913E-3 4.698E-2
3.130E-1
1.000E0
 2 9
26 HP:0000526 Aniridia 2.913E-3 4.698E-2
3.130E-1
1.000E0
 2 9
27 HP:0009943 Complete duplication of thumb phalanx 2.913E-3 4.698E-2
3.130E-1
1.000E0
 2 9
28 HP:0006740 Transitional cell carcinoma of the bladder 3.069E-3 4.698E-2
3.130E-1
1.000E0
 3 32
29 HP:0000520 Proptosis 3.103E-3 4.698E-2
3.130E-1
1.000E0
 5 109
Show 24 more annotations

5: Mouse Phenotype [Display Chart] 1458 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004046 abnormal mitosis 6.177E-25 7.157E-22 5.627E-21 9.006E-22 27 145
2 MP:0003077 abnormal cell cycle 9.818E-25 7.157E-22 5.627E-21 1.431E-21 35 309
3 MP:0003111 abnormal cell nucleus morphology 8.353E-19 4.060E-16 3.192E-15 1.218E-15 24 177
4 MP:0009760 abnormal mitotic spindle morphology 2.980E-14 1.086E-11 8.540E-11 4.345E-11 12 40
5 MP:0004023 abnormal chromosome number 1.132E-12 3.302E-10 2.596E-9 1.651E-9 14 83
6 MP:0004024 aneuploidy 1.123E-11 2.729E-9 2.145E-8 1.637E-8 12 63
7 MP:0006204 embryonic lethality before implantation 2.190E-10 4.561E-8 3.586E-7 3.193E-7 16 169
8 MP:0002718 abnormal inner cell mass morphology 3.829E-10 6.978E-8 5.487E-7 5.583E-7 12 84
9 MP:0004957 abnormal blastocyst morphology 4.380E-9 6.386E-7 5.021E-6 6.386E-6 16 207
10 MP:0014137 abnormal preimplantation embryo morphology 4.380E-9 6.386E-7 5.021E-6 6.386E-6 16 207
11 MP:0011094 embryonic lethality before implantation, complete penetrance 2.159E-8 2.788E-6 2.192E-5 3.148E-5 13 144
12 MP:0006205 embryonic lethality between implantation and somite formation 2.294E-8 2.788E-6 2.192E-5 3.345E-5 18 299
13 MP:0011096 embryonic lethality between implantation and somite formation, complete penetrance 3.040E-8 3.409E-6 2.680E-5 4.432E-5 17 270
14 MP:0009762 abnormal mitotic spindle assembly checkpoint 6.359E-8 6.623E-6 5.207E-5 9.272E-5 5 10
15 MP:0008866 chromosomal instability 1.288E-7 1.252E-5 9.845E-5 1.878E-4 11 113
16 MP:0010094 abnormal chromosome stability 1.544E-7 1.407E-5 1.107E-4 2.252E-4 11 115
17 MP:0003702 abnormal chromosome morphology 2.785E-7 2.388E-5 1.878E-4 4.060E-4 9 74
18 MP:0009850 embryonic lethality between implantation and placentation 3.566E-7 2.889E-5 2.271E-4 5.199E-4 20 439
19 MP:0009781 abnormal preimplantation embryo development 4.409E-7 3.383E-5 2.660E-4 6.428E-4 9 78
20 MP:0004045 abnormal cell cycle checkpoint function 9.414E-7 6.863E-5 5.396E-4 1.373E-3 8 63
21 MP:0011092 embryonic lethality, complete penetrance 4.310E-6 2.992E-4 2.353E-3 6.284E-3 18 426
22 MP:0001930 abnormal meiosis 4.560E-6 3.022E-4 2.376E-3 6.649E-3 12 194
23 MP:0012431 increased lymphoma incidence 9.211E-6 5.839E-4 4.591E-3 1.343E-2 13 244
24 MP:0001931 abnormal oogenesis 1.296E-5 7.874E-4 6.191E-3 1.890E-2 10 147
25 MP:0010296 increased hemolymphoid system tumor incidence 1.418E-5 8.272E-4 6.504E-3 2.068E-2 14 293
26 MP:0004028 chromosome breakage 2.549E-5 1.429E-3 1.124E-2 3.716E-2 7 71
27 MP:0003694 failure of blastocyst to hatch from the zona pellucida 3.484E-5 1.881E-3 1.479E-2
5.080E-2
 5 31
28 MP:0003706 abnormal cell nucleus count 4.666E-5 2.399E-3 1.886E-2
6.803E-2
 4 17
29 MP:0004965 inner cell mass degeneration 4.772E-5 2.399E-3 1.886E-2
6.957E-2
 5 33
30 MP:0002209 decreased germ cell number 5.731E-5 2.785E-3 2.190E-2
8.356E-2
 17 468
31 MP:0004760 increased mitotic index 5.942E-5 2.795E-3 2.197E-2
8.663E-2
 4 18
32 MP:0003693 abnormal blastocyst hatching 7.359E-5 3.353E-3 2.636E-2
1.073E-1
 5 36
33 MP:0008007 abnormal cellular replicative senescence 8.842E-5 3.907E-3 3.071E-2
1.289E-1
 7 86
34 MP:0005168 abnormal female meiosis 1.098E-4 4.707E-3 3.701E-2
1.601E-1
 6 62
35 MP:0002038 increased carcinoma incidence 1.158E-4 4.825E-3 3.794E-2
1.689E-1
 13 311
36 MP:0011104 embryonic lethality before implantation, incomplete penetrance 1.367E-4 5.537E-3 4.353E-2
1.993E-1
 4 22
37 MP:0008008 early cellular replicative senescence 2.933E-4 1.156E-2
9.088E-2
4.277E-1
 6 74
38 MP:0004025 polyploidy 3.614E-4 1.372E-2
1.079E-1
5.269E-1
 4 28
39 MP:0001125 abnormal oocyte morphology 3.671E-4 1.372E-2
1.079E-1
5.352E-1
 7 108
40 MP:0006254 thin cerebral cortex 4.833E-4 1.762E-2
1.385E-1
7.046E-1
 7 113
41 MP:0006361 abnormal female germ cell morphology 5.097E-4 1.813E-2
1.425E-1
7.432E-1
 7 114
42 MP:0010279 increased gastrointestinal tumor incidence 5.660E-4 1.965E-2
1.545E-1
8.253E-1
 7 116
43 MP:0003707 increased cell nucleus count 7.522E-4 2.551E-2
2.005E-1
1.000E0
 3 15
44 MP:0002021 increased incidence of induced tumors 8.363E-4 2.733E-2
2.149E-1
1.000E0
 8 161
45 MP:0002018 increased malignant tumor incidence 8.435E-4 2.733E-2
2.149E-1
1.000E0
 13 382
46 MP:0010159 abnormal enterocyte differentiation 8.951E-4 2.837E-2
2.231E-1
1.000E0
 2 4
47 MP:0003406 failure of zygotic cell division 1.104E-3 3.425E-2
2.693E-1
1.000E0
 3 17
48 MP:0010292 increased alimentary system tumor incidence 1.217E-3 3.696E-2
2.906E-1
1.000E0
 7 132
49 MP:0001730 embryonic growth arrest 1.280E-3 3.809E-2
2.994E-1
1.000E0
 11 303
Show 44 more annotations

6: Domain [Display Chart] 885 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR027640 Kinesin-like fam InterPro 3.128E-16 5.562E-14 4.096E-13 2.768E-13 13 43
2 PS00411 KINESIN MOTOR 1 PROSITE 4.400E-16 5.562E-14 4.096E-13 3.894E-13 13 44
3 PS50067 KINESIN MOTOR 2 PROSITE 4.400E-16 5.562E-14 4.096E-13 3.894E-13 13 44
4 SM00129 KISc SMART 4.400E-16 5.562E-14 4.096E-13 3.894E-13 13 44
5 PF00225 Kinesin Pfam 4.400E-16 5.562E-14 4.096E-13 3.894E-13 13 44
6 3.40.850.10 - Gene3D 4.400E-16 5.562E-14 4.096E-13 3.894E-13 13 44
7 IPR001752 Kinesin motor dom InterPro 4.400E-16 5.562E-14 4.096E-13 3.894E-13 13 44
8 IPR019821 Kinesin motor CS InterPro 6.975E-15 7.716E-13 5.682E-12 6.173E-12 12 41
9 PF02984 Cyclin C Pfam 2.436E-5 1.960E-3 1.443E-2 2.156E-2 4 17
10 SM01332 Cyclin C SMART 2.436E-5 1.960E-3 1.443E-2 2.156E-2 4 17
11 IPR004367 Cyclin C-dom InterPro 2.436E-5 1.960E-3 1.443E-2 2.156E-2 4 17
12 IPR008936 Rho GTPase activation prot InterPro 3.702E-5 2.446E-3 1.801E-2 3.276E-2 7 88
13 1.10.555.10 - Gene3D 5.344E-5 2.446E-3 1.801E-2 4.730E-2 6 64
14 IPR000198 RhoGAP dom InterPro 5.344E-5 2.446E-3 1.801E-2 4.730E-2 6 64
15 PS50238 RHOGAP PROSITE 5.344E-5 2.446E-3 1.801E-2 4.730E-2 6 64
16 PF15259 GTSE1 N Pfam 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
17 PF08311 Mad3 BUB1 I Pfam 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
18 PF15276 PP1 bind Pfam 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
19 PS00945 CKS 2 PROSITE 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
20 IPR031794 HMMR C InterPro 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
21 IPR026971 CND1/NCAPD3 InterPro 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
22 IPR013212 Mad3/Bub1 I InterPro 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
23 IPR029334 PP1-bd InterPro 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
24 IPR029197 CKAP2 C InterPro 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
25 PF15297 CKAP2 C Pfam 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
26 PS51489 BUB1 N PROSITE 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
27 SM00777 Mad3 BUB1 I SMART 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
28 PS00944 CKS 1 PROSITE 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
29 IPR026165 CKAP2 fam InterPro 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
30 PF01111 CKS Pfam 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
31 SM01084 CKS SMART 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
32 IPR032768 GTSE1 N InterPro 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
33 IPR032682 Cnd1 C InterPro 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
34 IPR000789 Cyclin-dep kinase reg-sub InterPro 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
35 IPR015661 Bub1/Mad3 InterPro 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
36 PF12717 Cnd1 Pfam 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
37 IPR026657 DDA3/GTSE-1 InterPro 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
38 3.30.170.10 - Gene3D 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
39 PF15908 HMMR C Pfam 1.078E-4 2.446E-3 1.801E-2
9.539E-2
 2 2
40 PS00108 PROTEIN KINASE ST PROSITE 1.125E-4 2.489E-3 1.833E-2
9.957E-2
 13 362
41 IPR011989 ARM-like InterPro 1.322E-4 2.853E-3 2.101E-2
1.170E-1
 11 271
42 PF02985 HEAT Pfam 1.382E-4 2.911E-3 2.144E-2
1.223E-1
 5 48
43 PF00069 Pkinase Pfam 1.863E-4 3.834E-3 2.823E-2
1.649E-1
 13 381
44 PS00292 CYCLINS PROSITE 1.916E-4 3.854E-3 2.837E-2
1.696E-1
 4 28
45 IPR030616 Aur InterPro 3.211E-4 5.684E-3 4.185E-2
2.842E-1
 2 3
46 PF06617 M-inducer phosp Pfam 3.211E-4 5.684E-3 4.185E-2
2.842E-1
 2 3
47 IPR017967 HMG boxA CS InterPro 3.211E-4 5.684E-3 4.185E-2
2.842E-1
 2 3
48 IPR000751 MPI Phosphatase InterPro 3.211E-4 5.684E-3 4.185E-2
2.842E-1
 2 3
49 PF08174 Anillin Pfam 3.211E-4 5.684E-3 4.185E-2
2.842E-1
 2 3
50 IPR012966 AHD InterPro 3.211E-4 5.684E-3 4.185E-2
2.842E-1
 2 3
Show 45 more annotations

7: Pathway [Display Chart] 549 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 105765 Cell Cycle, Mitotic BioSystems: REACTOME 2.220E-75 1.219E-72 8.391E-72 1.219E-72 77 416
2 105815 Mitotic Prometaphase BioSystems: REACTOME 6.752E-59 1.853E-56 1.276E-55 3.707E-56 45 112
3 105812 M Phase BioSystems: REACTOME 8.681E-55 1.589E-52 1.094E-51 4.766E-52 53 232
4 730315 Resolution of Sister Chromatid Cohesion BioSystems: REACTOME 2.119E-51 2.909E-49 2.003E-48 1.164E-48 40 103
5 105818 Mitotic Anaphase BioSystems: REACTOME 7.695E-42 8.449E-40 5.819E-39 4.225E-39 41 179
6 730317 Mitotic Metaphase and Anaphase BioSystems: REACTOME 9.881E-42 9.041E-40 6.226E-39 5.425E-39 41 180
7 730318 Separation of Sister Chromatids BioSystems: REACTOME 1.596E-41 1.252E-39 8.619E-39 8.762E-39 40 168
8 138007 PLK1 signaling events BioSystems: Pathway Interaction Database 1.433E-25 9.836E-24 6.773E-23 7.869E-23 19 44
9 138080 Aurora B signaling BioSystems: Pathway Interaction Database 6.198E-25 3.781E-23 2.604E-22 3.403E-22 18 39
10 105801 G2/M Transition BioSystems: REACTOME 1.061E-21 5.825E-20 4.011E-19 5.825E-19 23 118
11 160942 Mitotic G2-G2/M phases BioSystems: REACTOME 1.595E-21 7.961E-20 5.482E-19 8.757E-19 23 120
12 920977 RB in Cancer BioSystems: WikiPathways 1.174E-17 5.371E-16 3.699E-15 6.446E-15 18 87
13 771569 Regulation of PLK1 Activity at G2/M Transition BioSystems: REACTOME 1.190E-16 5.026E-15 3.461E-14 6.534E-14 17 83
14 137935 FOXM1 transcription factor network BioSystems: Pathway Interaction Database 4.923E-16 1.931E-14 1.330E-13 2.703E-13 13 39
15 187197 Kinesins BioSystems: REACTOME 4.157E-15 1.522E-13 1.048E-12 2.282E-12 11 26
16 83054 Cell cycle BioSystems: KEGG 1.325E-13 4.547E-12 3.131E-11 7.275E-11 17 124
17 730316 Condensation of Prometaphase Chromosomes BioSystems: REACTOME 1.984E-13 6.241E-12 4.297E-11 1.089E-10 8 12
18 105807 Centrosome maturation BioSystems: REACTOME 2.160E-13 6.241E-12 4.297E-11 1.186E-10 14 74
19 105808 Recruitment of mitotic centrosome proteins and complexes BioSystems: REACTOME 2.160E-13 6.241E-12 4.297E-11 1.186E-10 14 74
20 105811 Loss of Nlp from mitotic centrosomes BioSystems: REACTOME 6.144E-13 1.606E-11 1.106E-10 3.373E-10 13 64
21 105810 Loss of proteins required for interphase microtubule organization from the centrosome BioSystems: REACTOME 6.144E-13 1.606E-11 1.106E-10 3.373E-10 13 64
22 198811 Cell cycle BioSystems: WikiPathways 1.379E-12 3.442E-11 2.370E-10 7.573E-10 15 102
23 137925 Aurora A signaling BioSystems: Pathway Interaction Database 7.745E-11 1.849E-9 1.273E-8 4.252E-8 9 31
24 105802 Cyclin A/B1 associated events during G2/M transition BioSystems: REACTOME 1.156E-10 2.645E-9 1.821E-8 6.348E-8 8 22
25 105825 APC/C-mediated degradation of cell cycle proteins BioSystems: REACTOME 5.027E-10 1.062E-8 7.310E-8 2.760E-7 12 86
26 160944 Regulation of mitotic cell cycle BioSystems: REACTOME 5.027E-10 1.062E-8 7.310E-8 2.760E-7 12 86
27 105806 Polo-like kinase mediated events BioSystems: REACTOME 6.300E-10 1.281E-8 8.822E-8 3.459E-7 7 17
28 760635 Gastric cancer network 1 BioSystems: WikiPathways 1.529E-9 2.997E-8 2.064E-7 8.392E-7 9 42
29 161050 Deposition of New CENPA-containing Nucleosomes at the Centromere BioSystems: REACTOME 6.522E-9 1.194E-7 8.219E-7 3.581E-6 10 66
30 161049 Nucleosome assembly BioSystems: REACTOME 6.522E-9 1.194E-7 8.219E-7 3.581E-6 10 66
31 126909 Oocyte meiosis BioSystems: KEGG 9.011E-9 1.596E-7 1.099E-6 4.947E-6 12 110
32 161048 Chromosome Maintenance BioSystems: REACTOME 4.223E-8 7.245E-7 4.989E-6 2.319E-5 12 126
33 M17370 Role of Ran in mitotic spindle regulation MSigDB C2 BIOCARTA (v5.1) 6.205E-8 1.032E-6 7.108E-6 3.406E-5 5 10
34 105804 Cyclin B2 mediated events BioSystems: REACTOME 1.075E-7 1.737E-6 1.196E-5 5.904E-5 4 5
35 105829 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins BioSystems: REACTOME 2.720E-7 4.267E-6 2.938E-5 1.493E-4 9 74
36 105827 Phosphorylation of Emi1 BioSystems: REACTOME 3.196E-7 4.873E-6 3.356E-5 1.754E-4 4 6
37 105739 Cell Cycle Checkpoints BioSystems: REACTOME 3.285E-7 4.874E-6 3.356E-5 1.803E-4 11 124
38 645290 MHC class II antigen presentation BioSystems: REACTOME 4.966E-7 7.175E-6 4.941E-5 2.727E-4 10 103
39 105826 Regulation of APC/C activators between G1/S and early anaphase BioSystems: REACTOME 5.972E-7 8.407E-6 5.789E-5 3.279E-4 9 81
40 771571 Activation of NIMA Kinases NEK9, NEK6, NEK7 BioSystems: REACTOME 7.386E-7 1.014E-5 6.980E-5 4.055E-4 4 7
41 119304 Progesterone-mediated oocyte maturation BioSystems: KEGG 9.996E-7 1.339E-5 9.218E-5 5.488E-4 9 86
42 187196 Factors involved in megakaryocyte development and platelet production BioSystems: REACTOME 1.038E-6 1.357E-5 9.344E-5 5.699E-4 11 139
43 105831 APC/C:Cdc20 mediated degradation of mitotic proteins BioSystems: REACTOME 2.875E-6 3.587E-5 2.470E-4 1.578E-3 8 73
44 137934 E2F transcription factor network BioSystems: Pathway Interaction Database 2.875E-6 3.587E-5 2.470E-4 1.578E-3 8 73
45 760637 Gastric cancer network 2 BioSystems: WikiPathways 3.101E-6 3.784E-5 2.606E-4 1.703E-3 6 34
46 198778 Fluoropyrimidine Activity BioSystems: WikiPathways 3.706E-6 4.423E-5 3.045E-4 2.034E-3 6 35
47 105764 Inactivation of APC/C via direct inhibition of the APC/C complex BioSystems: REACTOME 4.494E-6 5.141E-5 3.540E-4 2.467E-3 5 21
48 105763 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components BioSystems: REACTOME 4.494E-6 5.141E-5 3.540E-4 2.467E-3 5 21
49 105755 Mitotic Spindle Checkpoint BioSystems: REACTOME 5.759E-6 6.453E-5 4.443E-4 3.162E-3 5 22
50 M13022 Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle MSigDB C2 BIOCARTA (v5.1) 6.702E-6 7.215E-5 4.968E-4 3.679E-3 4 11
Show 45 more annotations

8: Pubmed [Display Chart] 19523 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16565220 Phosphoproteome analysis of the human mitotic spindle. Pubmed 9.388E-60 1.833E-55 1.916E-54 1.833E-55 42 210
2 20508983:gr Centrosome-related genes, genetic variation, and risk of breast cancer. GeneRIF 2.973E-34 1.935E-30 2.023E-29 5.804E-30 23 102
3 20508983 Centrosome-related genes, genetic variation, and risk of breast cancer. Pubmed 2.973E-34 1.935E-30 2.023E-29 5.804E-30 23 102
4 21399614 Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Pubmed 2.314E-30 1.130E-26 1.181E-25 4.518E-26 23 146
5 24613305 Proximity interactions among centrosome components identify regulators of centriole duplication. Pubmed 1.131E-28 4.414E-25 4.616E-24 2.207E-24 20 101
6 15843429 Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Pubmed 9.009E-21 2.931E-17 3.065E-16 1.759E-16 9 11
7 15504738 Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. Pubmed 1.091E-19 2.839E-16 2.969E-15 2.130E-15 10 20
8 25750436 MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C. Pubmed 1.163E-19 2.839E-16 2.969E-15 2.271E-15 9 13
9 25852190 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Pubmed 1.163E-17 2.524E-14 2.639E-13 2.271E-13 21 401
10 17268547 Reconstitution and subunit geometry of human condensin complexes. Pubmed 9.439E-17 1.675E-13 1.752E-12 1.843E-12 7 8
11 14532007 Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. Pubmed 9.439E-17 1.675E-13 1.752E-12 1.843E-12 7 8
12 16622419 The human CENP-A centromeric nucleosome-associated complex. Pubmed 1.423E-16 2.314E-13 2.420E-12 2.777E-12 10 36
13 11076968 The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion. Pubmed 2.879E-16 4.324E-13 4.521E-12 5.621E-12 11 56
14 16462731 The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation. Pubmed 3.556E-16 4.959E-13 5.185E-12 6.942E-12 11 57
15 12852856 Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. Pubmed 4.373E-16 5.692E-13 5.952E-12 8.538E-12 11 58
16 7790358 Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function. Pubmed 7.950E-16 9.700E-13 1.014E-11 1.552E-11 11 61
17 25669885 The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators. Pubmed 1.407E-15 1.445E-12 1.511E-11 2.746E-11 7 10
18 19468067 Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. Pubmed 1.407E-15 1.445E-12 1.511E-11 2.746E-11 7 10
19 22371557 Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction. Pubmed 1.407E-15 1.445E-12 1.511E-11 2.746E-11 7 10
20 12221128 Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex. Pubmed 2.008E-15 1.960E-12 2.050E-11 3.921E-11 11 66
21 15009096 Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. Pubmed 2.793E-15 2.276E-12 2.380E-11 5.453E-11 10 47
22 11136719 Chromosome condensation by a human condensin complex in Xenopus egg extracts. Pubmed 3.147E-15 2.276E-12 2.380E-11 6.145E-11 6 6
23 19008095:gr Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study. GeneRIF 3.147E-15 2.276E-12 2.380E-11 6.145E-11 6 6
24 16431929 KIF14 and citron kinase act together to promote efficient cytokinesis. Pubmed 3.147E-15 2.276E-12 2.380E-11 6.145E-11 6 6
25 18195732 Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis. Pubmed 3.147E-15 2.276E-12 2.380E-11 6.145E-11 6 6
26 19008095 Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study. Pubmed 3.147E-15 2.276E-12 2.380E-11 6.145E-11 6 6
27 16760428 Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. Pubmed 3.147E-15 2.276E-12 2.380E-11 6.145E-11 6 6
28 26387737 Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1. Pubmed 1.992E-14 1.389E-11 1.452E-10 3.888E-10 7 13
29 23791783 Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20. Pubmed 2.196E-14 1.478E-11 1.546E-10 4.287E-10 6 7
30 26166704 Condensin I and II Complexes License Full Estrogen Receptor ¿-Dependent Enhancer Activation. Pubmed 3.970E-14 2.500E-11 2.615E-10 7.751E-10 7 14
31 20231385 Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes. Pubmed 3.970E-14 2.500E-11 2.615E-10 7.751E-10 7 14
32 17388661 Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen. Pubmed 4.528E-14 2.763E-11 2.889E-10 8.841E-10 8 25
33 16622420 The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Pubmed 7.420E-14 4.390E-11 4.590E-10 1.449E-9 7 15
34 17360335 Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint. Pubmed 8.756E-14 4.884E-11 5.107E-10 1.709E-9 6 8
35 24151075 Monopolar spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) conformer and assembly of the mitotic checkpoint complex. Pubmed 8.756E-14 4.884E-11 5.107E-10 1.709E-9 6 8
36 23160376 Transcriptional intermediary factor 1¿ binds to the anaphase-promoting complex/cyclosome and promotes mitosis. Pubmed 2.228E-13 1.208E-10 1.263E-9 4.350E-9 7 17
37 10366450 Characterization of MAD2B and other mitotic spindle checkpoint genes. Pubmed 2.618E-13 1.345E-10 1.407E-9 5.112E-9 6 9
38 18471975 Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A. Pubmed 2.618E-13 1.345E-10 1.407E-9 5.112E-9 6 9
39 22193957 BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner. Pubmed 3.634E-13 1.819E-10 1.902E-9 7.094E-9 7 18
40 16716197 Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. Pubmed 6.525E-13 3.185E-10 3.330E-9 1.274E-8 6 10
41 15989971 Mutual inhibition of separase and Cdk1 by two-step complex formation. Pubmed 8.326E-13 3.612E-10 3.777E-9 1.625E-8 5 5
42 17210994:gr Breast cancer risk associated with genotypic polymorphism of the mitotic checkpoint genes: a multigenic study on cancer susceptibility. GeneRIF 8.326E-13 3.612E-10 3.777E-9 1.625E-8 5 5
43 17210994 Breast cancer risk associated with genotypic polymorphism of the mitotic checkpoint genes: a multigenic study on cancer susceptibility. Pubmed 8.326E-13 3.612E-10 3.777E-9 1.625E-8 5 5
44 15525512 Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. Pubmed 8.326E-13 3.612E-10 3.777E-9 1.625E-8 5 5
45 18773538 Aurora kinase-A regulates kinetochore/chromatin associated microtubule assembly in human cells. Pubmed 8.326E-13 3.612E-10 3.777E-9 1.625E-8 5 5
46 19454010 In vitro nuclear interactome of the HIV-1 Tat protein. Pubmed 1.023E-12 4.343E-10 4.541E-9 1.998E-8 13 195
47 19117984 Functional interaction between BubR1 and securin in an anaphase-promoting complex/cyclosomeCdc20-independent manner. Pubmed 4.980E-12 1.870E-9 1.955E-8 9.722E-8 5 6
48 17268814 Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer risk. Pubmed 4.980E-12 1.870E-9 1.955E-8 9.722E-8 5 6
49 19357306 A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Pubmed 4.980E-12 1.870E-9 1.955E-8 9.722E-8 5 6
50 17268814:gr Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer risk. GeneRIF 4.980E-12 1.870E-9 1.955E-8 9.722E-8 5 6
Show 45 more annotations

9: Interaction [Display Chart] 4428 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:CDK1 CDK1 interactions 1.204E-28 5.334E-25 4.786E-24 5.334E-25 37 270
2 int:HIST1H2BG HIST1H2BG interactions 2.564E-24 5.676E-21 5.093E-20 1.135E-20 31 222
3 int:PCM1 PCM1 interactions 7.690E-22 1.135E-18 1.018E-17 3.405E-18 29 224
4 int:FZR1 FZR1 interactions 9.006E-19 9.970E-16 8.946E-15 3.988E-15 21 121
5 int:SPICE1 SPICE1 interactions 4.187E-18 3.708E-15 3.327E-14 1.854E-14 22 148
6 int:CDC20 CDC20 interactions 8.740E-18 5.560E-15 4.989E-14 3.870E-14 22 153
7 int:BUB1B BUB1B interactions 8.790E-18 5.560E-15 4.989E-14 3.892E-14 18 86
8 int:OFD1 OFD1 interactions 2.663E-17 1.474E-14 1.322E-13 1.179E-13 26 249
9 int:PLK1 PLK1 interactions 3.516E-17 1.730E-14 1.552E-13 1.557E-13 25 228
10 int:KIAA0753 KIAA0753 interactions 2.210E-16 9.786E-14 8.781E-13 9.786E-13 18 102
11 int:DCTN1 DCTN1 interactions 3.278E-16 1.320E-13 1.184E-12 1.451E-12 24 226
12 int:AURKB AURKB interactions 4.405E-16 1.625E-13 1.459E-12 1.951E-12 21 162
13 int:CCNB1 CCNB1 interactions 1.047E-15 3.567E-13 3.201E-12 4.638E-12 19 129
14 int:NDC80 NDC80 interactions 2.226E-15 7.041E-13 6.318E-12 9.857E-12 15 68
15 int:BUB1 BUB1 interactions 2.628E-15 7.757E-13 6.960E-12 1.163E-11 13 44
16 int:CEP170 CEP170 interactions 4.666E-15 1.291E-12 1.159E-11 2.066E-11 20 160
17 int:NSL1 NSL1 interactions 6.061E-15 1.579E-12 1.417E-11 2.684E-11 11 27
18 int:KNL1 KNL1 interactions 2.461E-14 5.967E-12 5.354E-11 1.090E-10 11 30
19 int:AURKA AURKA interactions 2.561E-14 5.967E-12 5.354E-11 1.134E-10 24 274
20 int:CCDC14 CCDC14 interactions 5.492E-14 1.216E-11 1.091E-10 2.432E-10 14 68
21 int:CEP128 CEP128 interactions 2.641E-13 5.568E-11 4.996E-10 1.169E-9 23 276
22 int:CENPH CENPH interactions 3.413E-13 6.870E-11 6.164E-10 1.511E-9 10 27
23 int:NIN NIN interactions 4.485E-13 8.635E-11 7.748E-10 1.986E-9 16 114
24 int:PRC1 PRC1 interactions 5.254E-13 9.694E-11 8.699E-10 2.327E-9 10 28
25 int:NUF2 NUF2 interactions 9.385E-13 1.662E-10 1.492E-9 4.156E-9 11 40
26 int:CEP120 CEP120 interactions 4.369E-12 7.440E-10 6.676E-9 1.934E-8 14 92
27 int:TTK TTK interactions 7.966E-12 1.306E-9 1.172E-8 3.527E-8 12 62
28 int:ANAPC4 ANAPC4 interactions 8.439E-12 1.335E-9 1.197E-8 3.737E-8 11 48
29 int:FOXM1 FOXM1 interactions 1.186E-11 1.811E-9 1.625E-8 5.252E-8 12 64
30 int:SPC24 SPC24 interactions 1.706E-11 2.518E-9 2.259E-8 7.554E-8 10 38
31 int:CENPA CENPA interactions 2.436E-11 3.479E-9 3.122E-8 1.079E-7 13 85
32 int:SMC2 SMC2 interactions 2.522E-11 3.490E-9 3.132E-8 1.117E-7 12 68
33 int:CENPN CENPN interactions 5.129E-11 6.882E-9 6.175E-8 2.271E-7 7 13
34 int:E2F4 E2F4 interactions 6.759E-11 8.802E-9 7.898E-8 2.993E-7 14 112
35 int:HIST1H3A HIST1H3A interactions 8.763E-11 1.109E-8 9.948E-8 3.880E-7 20 270
36 int:CENPM CENPM interactions 1.015E-10 1.249E-8 1.121E-7 4.496E-7 7 14
37 int:MIS12 MIS12 interactions 1.270E-10 1.520E-8 1.364E-7 5.624E-7 9 33
38 int:SDCCAG3 SDCCAG3 interactions 2.128E-10 2.416E-8 2.168E-7 9.421E-7 10 48
39 int:CENPU CENPU interactions 2.128E-10 2.416E-8 2.168E-7 9.421E-7 10 48
40 int:ODF2 ODF2 interactions 3.008E-10 3.330E-8 2.988E-7 1.332E-6 14 125
41 int:CDC27 CDC27 interactions 3.307E-10 3.571E-8 3.205E-7 1.464E-6 13 104
42 int:CEP85 CEP85 interactions 3.931E-10 4.145E-8 3.719E-7 1.741E-6 9 37
43 int:MAD2L1 MAD2L1 interactions 7.525E-10 7.749E-8 6.953E-7 3.332E-6 11 71
44 int:INCENP INCENP interactions 1.417E-9 1.426E-7 1.280E-6 6.275E-6 7 19
45 int:MED4 MED4 interactions 1.715E-9 1.688E-7 1.514E-6 7.595E-6 21 354
46 int:DSN1 DSN1 interactions 2.084E-9 2.006E-7 1.800E-6 9.228E-6 9 44
47 int:NCAPH NCAPH interactions 2.578E-9 2.429E-7 2.179E-6 1.142E-5 9 45
48 int:NINL NINL interactions 4.227E-9 3.900E-7 3.499E-6 1.872E-5 16 208
49 int:CCNF CCNF interactions 4.375E-9 3.954E-7 3.548E-6 1.937E-5 6 13
50 int:CNTRL CNTRL interactions 6.660E-9 5.898E-7 5.293E-6 2.949E-5 14 158
Show 45 more annotations

10: Cytoband [Display Chart] 168 annotations before applied cutoff / 34661 genes in category

No results to display

11: Transcription Factor Binding Site [Display Chart] 374 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$NFY Q6 V$NFY Q6 1.197E-6 4.476E-4 2.911E-3 4.476E-4 12 211
2 V$E2F1 Q6 V$E2F1 Q6 1.271E-5 6.859E-4 4.460E-3 4.752E-3 10 181
3 V$E2F Q6 V$E2F Q6 1.333E-5 6.859E-4 4.460E-3 4.987E-3 10 182
4 V$E2F4DP2 01 V$E2F4DP2 01 1.467E-5 6.859E-4 4.460E-3 5.487E-3 10 184
5 V$E2F1DP2 01 V$E2F1DP2 01 1.467E-5 6.859E-4 4.460E-3 5.487E-3 10 184
6 V$E2F Q4 V$E2F Q4 1.467E-5 6.859E-4 4.460E-3 5.487E-3 10 184
7 V$E2F 02 V$E2F 02 1.467E-5 6.859E-4 4.460E-3 5.487E-3 10 184
8 V$E2F1DP1 01 V$E2F1DP1 01 1.467E-5 6.859E-4 4.460E-3 5.487E-3 10 184
9 V$E2F4DP1 01 V$E2F4DP1 01 1.853E-5 7.255E-4 4.718E-3 6.931E-3 10 189
10 V$E2F1 Q3 V$E2F1 Q3 1.940E-5 7.255E-4 4.718E-3 7.255E-3 10 190
11 V$E2F1DP1RB 01 V$E2F1DP1RB 01 9.124E-5 3.102E-3 2.017E-2 3.412E-2 9 184
12 V$NFY 01 V$NFY 01 1.536E-4 4.786E-3 3.112E-2
5.744E-2
 9 197
13 V$NFY Q6 01 V$NFY Q6 01 2.481E-4 7.138E-3 4.642E-2
9.280E-2
 9 210
14 V$E2F Q6 01 V$E2F Q6 01 5.044E-4 1.304E-2
8.478E-2
1.886E-1
 8 184
15 V$E2F Q4 01 V$E2F Q4 01 5.229E-4 1.304E-2
8.478E-2
1.956E-1
 8 185
16 V$E2F1 Q6 01 V$E2F1 Q6 01 6.025E-4 1.408E-2
9.158E-2
2.253E-1
 8 189
17 V$NFY C V$NFY C 1.025E-3 2.254E-2
1.466E-1
3.832E-1
 8 205
18 V$E2F Q3 V$E2F Q3 1.970E-3 4.093E-2
2.661E-1
7.367E-1
 7 177
19 V$E2F1 Q4 01 V$E2F1 Q4 01 2.236E-3 4.401E-2
2.862E-1
8.362E-1
 7 181
20 V$E2F Q3 01 V$E2F Q3 01 2.607E-3 4.875E-2
3.170E-1
9.749E-1
 7 186
Show 15 more annotations

12: Gene Family [Display Chart] 52 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 622 Kinesins|Pleckstrin homology domain containing genenames.org 2.401E-20 1.248E-18 5.666E-18 1.248E-18 13 46
2 1338 Baculoviral IAP repeat containing|Chromosomal passenger complex genenames.org 4.877E-10 1.268E-8 5.754E-8 2.536E-8 4 4
3 548 Fanconi anemia complementation groups genenames.org 2.229E-6 3.195E-5 1.450E-4 1.159E-4 4 20
4 694 Protein phosphatase 1 regulatory subunits|BCL2 family genenames.org 2.458E-6 3.195E-5 1.450E-4 1.278E-4 8 181
5 473 Cyclins|Mediator complex genenames.org 1.057E-5 1.100E-4 4.990E-4 5.498E-4 4 29
6 511 Canonical high mobility group genenames.org 1.695E-5 1.469E-4 6.666E-4 8.814E-4 3 11
7 713 Class III Cys-based CDC25 phosphatases genenames.org 6.760E-5 5.022E-4 2.279E-3 3.515E-3 2 3
8 778 Tubulins genenames.org 2.536E-4 1.648E-3 7.480E-3 1.319E-2 3 26
9 135 Zinc fingers GRF-type genenames.org 4.673E-4 2.430E-3 1.103E-2 2.430E-2 2 7
10 761 Structural maintenance of chromosomes proteins|Cohesin complex genenames.org 4.673E-4 2.430E-3 1.103E-2 2.430E-2 2 7
11 721 Rho GTPase activating proteins|F-BAR domain containing genenames.org 1.760E-3 8.319E-3 3.775E-2
9.151E-2
 3 50
12 413 AAA ATPases genenames.org 2.082E-3 9.021E-3 4.094E-2
1.083E-1
 3 53
13 864 Histones genenames.org 2.324E-3 9.297E-3 4.219E-2
1.209E-1
 4 116
Show 8 more annotations

13: Coexpression [Display Chart] 4893 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M15664 The 'Cervical Cancer Proliferation Cluster' (CCPC): genes whose expression in cervical carcinoma positively correlates with that of the HPV E6 and E7 oncogenes; they are also differentially expressed according to disease outcome. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.031E-143 9.940E-140 9.018E-139 9.940E-140 85 140
2 M3580 Genes up-regulated in comparison of wild type CD8 effector T cells at day 6 versus those from mice defficient for TRAF6 [GeneID=7189] at day 10. MSigDB C7: Immunologic Signatures (v5.1) 1.284E-131 3.141E-128 2.850E-127 6.282E-128 88 200
3 M16010 Genes down-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.228E-127 1.342E-123 1.218E-122 4.026E-123 91 251
4 M3766 Up-regulated genes whose expression correlated with histologic grade of invasive breast cancer tumors: comparison of grade 1 vs grade 3. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.969E-116 3.632E-113 3.295E-112 1.453E-112 75 151
5 M2156 Genes up-regulated in MCF7 cells (breast cancer) at 24 h of estradiol [PubChemID=5757] treatment. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.811E-115 7.644E-112 6.935E-111 3.822E-111 91 324
6 M3577 Genes up-regulated in comparison of wild type CD8 effector T cells at day 6 versus those at day 10. MSigDB C7: Immunologic Signatures (v5.1) 1.262E-114 1.029E-111 9.335E-111 6.174E-111 80 200
7 M8520 Cluster 6 of method A: up-regulation of these genes in patients with non-small cell lung cancer (NSCLC) predicts poor survival outcome. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.329E-110 3.725E-107 3.379E-106 2.607E-106 97 456
8 M11537 Fibroblast serum response genes showing periodic expression during the cell cycle; excluded from the core serum response signature. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.705E-108 1.655E-105 1.501E-104 1.324E-104 71 148
9 M10279 Genes down-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [GeneID=9589] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.213E-104 5.009E-101 4.544E-100 4.508E-100 84 310
10 GSE13547 CTRL VS ANTI IGM STIM BCELL 12H UP Genes up-regulated in B lymphocytes: control versus stimulated by anti-IgM for 12h. MSigDB C7: Immunologic Signatures (v5.1) 4.647E-92 2.274E-89 2.063E-88 2.274E-88 67 182
11 M5041 Genes up-regulated in comparison of splenic primary CD8 effector T cells at day 8 post-acute infection versus splenic secondary CD8 effector T cells at day 8 post-acute infection. MSigDB C7: Immunologic Signatures (v5.1) 6.528E-89 2.904E-86 2.635E-85 3.194E-85 67 199
12 GSE39556 CD8A DC VS NK CELL MOUSE 3H POST POLYIC INJ UP Genes up-regulated after poly(IC) injection: CD8A [GeneID=925] dendritic cells versus NK cells. MSigDB C7: Immunologic Signatures (v5.1) 9.757E-89 3.978E-86 3.610E-85 4.774E-85 67 200
13 M14985 Genes up-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [GeneID=4904] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.271E-86 4.783E-84 4.340E-83 6.218E-83 73 290
14 M5588 Genes up-regulated during differentiation from large pre-BII to small pre-BII lymphocyte. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.507E-86 1.925E-83 1.746E-82 2.694E-82 62 163
15 M2608 Cell cycle genes significantly (p =< 0.05) changed in fibroblast cells at 24 h after exposure to ionizing radiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.567E-86 2.468E-83 2.239E-82 3.702E-82 58 128
16 M7854 Differentially expressed genes in a panel of xenografts representing 8 common pediatric tumors compared to the normal tissues. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.663E-85 2.343E-82 2.126E-81 3.750E-81 56 116
17 M18506 Genes down-regulated in the ANBL-6 cell line (multiple myeloma, MM) after withdrawal of IL6 [GeneID=3569]. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.830E-84 2.542E-81 2.306E-80 4.321E-80 53 98
18 M5901 Genes involved in the G2/M checkpoint, as in progression through the cell division cycle. MSigDB H: Hallmark Gene Sets (v5.1) 3.302E-81 8.977E-79 8.145E-78 1.616E-77 63 200
19 M18855 Up-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.222E-79 5.722E-77 5.191E-76 1.087E-75 77 428
20 M3155 Genes up-regulated in quiescent CD34+ [GeneID=8842] cells isolated from peripheral blood of normal donors compared to the dividing cells from CML (chronic myeloid leukemia) patients. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.241E-79 2.261E-76 2.051E-75 4.522E-75 60 181
21 M4622 Genes up-regulated in comparison of untreated CD25+ T effector cells at day 7 versus untreated CD25- T cells at day 7. MSigDB C7: Immunologic Signatures (v5.1) 1.603E-77 3.735E-75 3.389E-74 7.843E-74 61 200
22 M2077 Genes periodically expressed in synchronized HeLa cells (cervical carcinoma), with peak during the G2/M phase of cell cycle. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.005E-77 1.336E-74 1.212E-73 2.938E-73 62 216
23 M9516 Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA2 [GeneID=675] across a compendium of normal tissues. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.182E-76 2.514E-74 2.280E-73 5.781E-73 75 423
24 GSE37532 WT VS PPARG KO VISCERAL ADIPOSE TISSUE TREG UP Genes up-regulated in T reg from visceral adipose tissue of aged mice: wildtype versus PPARG [GeneID=5468] knockout. MSigDB C7: Immunologic Signatures (v5.1) 7.516E-76 1.532E-73 1.390E-72 3.678E-72 60 199
25 GSE14415 NATURAL TREG VS TCONV DN Genes down-regulated in natural T reg versus T conv. MSigDB C7: Immunologic Signatures (v5.1) 3.412E-75 6.677E-73 6.058E-72 1.669E-71 58 180
26 M7357 Genes up-regulated at early stages of progenitor T lymphocyte maturation compared to the late stages. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.343E-74 2.528E-72 2.294E-71 6.573E-71 50 107
27 M5925 Genes encoding cell cycle related targets of E2F transcription factors. MSigDB H: Hallmark Gene Sets (v5.1) 6.885E-74 1.203E-71 1.092E-70 3.369E-70 59 200
28 GSE39110 DAY3 VS DAY6 POST IMMUNIZATION CD8 TCELL DN Genes down-regulated in CD8 T cells after immunization: day 3 versus day 6. MSigDB C7: Immunologic Signatures (v5.1) 6.885E-74 1.203E-71 1.092E-70 3.369E-70 59 200
29 M1157 Genes up-regulated in MEF cells (embryonic fibroblasts) at 16 hr after serum stimulation and knockdown of E2F3 [GeneID=1871] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.703E-73 6.247E-71 5.668E-70 1.812E-69 48 97
30 M2076 Genes periodically expressed in synchronized HeLa cells (cervical carcinoma), with peak during the G2 phase of cell cycle. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.051E-73 8.238E-71 7.474E-70 2.471E-69 57 182
31 M3041 Genes up-regulated in comparison of effector CD8 T cells versus memory CD8 T cells. MSigDB C7: Immunologic Signatures (v5.1) 4.308E-72 6.800E-70 6.170E-69 2.108E-68 58 200
32 M3268 Top 200 marker genes up-regulated in the 'proliferation' subclass of hepatocellular carcinoma (HCC); characterized by increased proliferation, high levels of serum AFP [GeneID=174], and chromosomal instability. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.891E-72 1.207E-69 1.095E-68 3.861E-68 56 178
33 M2879 Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.538E-71 6.657E-69 6.040E-68 2.220E-67 67 342
34 M1915 Genes down-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.626E-71 6.657E-69 6.040E-68 2.264E-67 63 277
35 M5294 Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from young donors versus those treated with TSST at 72 h. MSigDB C7: Immunologic Signatures (v5.1) 2.613E-70 3.653E-68 3.315E-67 1.279E-66 57 200
36 GSE14415 INDUCED VS NATURAL TREG DN Genes down-regulated in T reg: induced versus natural. MSigDB C7: Immunologic Signatures (v5.1) 5.304E-70 7.209E-68 6.541E-67 2.595E-66 55 178
37 M6451 Genes down-regulated in P493-6 cells (B lymphocyte, Burkitt's lymphoma model) upon knockdown of TFRC [GeneID=7037] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.026E-69 1.357E-67 1.231E-66 5.021E-66 51 137
38 M1037 Genes up-regulated in gastric cancer cell lines: doxorubicin [PubChem=31703] resistant vs sensitive. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.796E-69 7.463E-67 6.771E-66 2.836E-65 39 54
39 GSE27241 WT VS RORGT KO TH17 POLARIZED CD4 TCELL UP Genes up-regulated in polarizing CD4 [GeneID=920] Th17 cells: wildtype versus RORC [GeneID=6097] knockout. MSigDB C7: Immunologic Signatures (v5.1) 2.963E-67 3.717E-65 3.372E-64 1.450E-63 52 161
40 GSE21063 WT VS NFATC1 KO 8H ANTI IGM STIM BCELL UP Genes up-regulated in B lymphocytes stimulated by anti-IgM for 8h: wildtype versus NFATC1 [GeneID=4772] knockout. MSigDB C7: Immunologic Signatures (v5.1) 8.751E-67 1.070E-64 9.712E-64 4.282E-63 55 200
41 M6387 Genes from the 254-gene classifier which were up-regulated in melanoma patients with a reported distant metastasis within 4 years. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.919E-65 3.484E-63 3.161E-62 1.428E-61 51 162
42 M10739 Genes down-regulated in ANBL-6 cell line (multiple myeloma, MM) expressing a constantly active form of NRAS [GeneID=4893] off a plasmid vector compared to those grown in the presence of IL6 [GeneID=3569]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.255E-63 1.462E-61 1.326E-60 6.138E-60 40 72
43 M5303 Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from old donors versus those treated with TSST at 72 h. MSigDB C7: Immunologic Signatures (v5.1) 2.581E-63 2.937E-61 2.664E-60 1.263E-59 53 200
44 M7094 Genes down-regulated in adult fibroblasts with inactivated RB1 [GeneID=5925] by Cre-lox: acute loss of function (LOF) of RB1. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.958E-63 3.289E-61 2.984E-60 1.447E-59 55 228
45 M11884 Genes up-regulated at the peak of an antigen response of naive CD8+ [GeneID=925;926] T-cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.358E-63 6.914E-61 6.273E-60 3.111E-59 62 346
46 GSE25088 WT VS STAT6 KO MACROPHAGE IL4 STIM DN Genes down-regulated in bone marrow-derived macrophages treated with IL4 [GeneID=3565]: wildtype versus STAT6 [GeneID=6778] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.336E-61 1.421E-59 1.289E-58 6.535E-58 52 200
47 M19287 Up-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: the Large Pre-BII stage. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.145E-59 2.233E-57 2.026E-56 1.049E-55 40 86
48 GSE13547 CTRL VS ANTI IGM STIM BCELL 2H UP Genes up-regulated in B lymphocytes: control versus stimulated by anti-IgM for 2h. MSigDB C7: Immunologic Signatures (v5.1) 4.530E-59 4.618E-57 4.190E-56 2.217E-55 49 180
49 M4888 Top 50 up-regulated genes in cluster PR of multiple myeloma samples characterized by increased expression of proliferation and cell cycle genes. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.035E-58 1.033E-56 9.374E-56 5.063E-55 33 45
50 M4604 Genes up-regulated in comparison of CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 7 versus CD25- T cells treated with IL4 [GeneID=3565] at day 7. MSigDB C7: Immunologic Signatures (v5.1) 3.244E-58 3.112E-56 2.824E-55 1.587E-54 50 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 1638 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM399397 500 alpha beta T cells, T.DPbl.Th, 4+ 8+ TCR-/lo FSChi, Thymus, avg-3 Immgen.org, GSE15907 5.026E-206 8.232E-203 6.568E-202 8.232E-203 142 399
2 GSM399452 500 B cells, preB.FrC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-3 Immgen.org, GSE15907 8.675E-191 7.104E-188 5.668E-187 1.421E-187 136 409
3 GSM399403 500 alpha beta T cells, T.ISP.Th, 4- 8+ TCR-/lo 24hi, Thymus, avg-3 Immgen.org, GSE15907 3.696E-168 2.018E-165 1.610E-164 6.054E-165 126 417
4 Lungmap Mouse e16.5 Proliferative fibroblast Top 500 All Mouse Lung E16.5 Proliferative fibroblast top 500 Lungmap Mouse Single Cell (Lungmap.net) 5.190E-163 2.125E-160 1.696E-159 8.501E-160 126 452
5 GSM538355 500 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R+ CD, Fetal Liver, avg-2 Immgen.org, GSE15907 2.778E-147 9.102E-145 7.262E-144 4.551E-144 116 422
6 GSM538358 500 B cells, proB.FrBC.FL, CD19+ IgM- CD43+ CD24+ AA4.1+ CD45R+, Fetal Liver, avg-3 Immgen.org, GSE15907 1.911E-146 5.217E-144 4.162E-143 3.130E-143 114 400
7 GSM538387 500 alpha beta T cells, T.8Eff.Sp.OT1.d5.VSVOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 4.973E-145 1.164E-142 9.285E-142 8.146E-142 114 410
8 GSM538357 500 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 2.196E-143 4.495E-141 3.587E-140 3.596E-140 114 422
9 GSM476664 500 gamma delta T cells, Tgd.vg3+24alo.e17.Th, TCRd+ Vg3+ CD24-, Fetal Thymus, avg-3 Immgen.org, GSE15907 6.327E-140 1.152E-137 9.188E-137 1.036E-136 112 419
10 GSM791143 500 alpha beta T cells, preT.DN3-4.Th, Lin-/lo CD25int CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 3.977E-137 6.514E-135 5.198E-134 6.514E-134 109 397
11 12Dn Top 500 Cluster 4 12Dn Top 500 Cluster 4 Brain Map - Allen iN 1.672E-134 2.489E-132 1.986E-131 2.738E-131 78 117
12 Lungmap Mouse e16.5 Proliferative fibroblast Top 500 Cluster 0 Mouse Lung E16.5 Proliferative fibroblast top 500 c0 Lungmap Mouse Single Cell (Lungmap.net) 6.428E-134 8.775E-132 7.001E-131 1.053E-130 73 94
13 GSM476660 500 gamma delta T cells, Tgd.vg2+24ahi.e17.Th, TCRd+ Vg2+ CD24+, Fetal Thymus, avg-3 Immgen.org, GSE15907 4.509E-131 5.681E-129 4.533E-128 7.386E-128 107 414
14 GSM538348 500 B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-2 Immgen.org, GSE15907 1.941E-130 2.271E-128 1.812E-127 3.180E-127 107 419
15 GSM399450 500 B cells, proB.FrBC.BM, CD19+ IgM- CD43+ AA4.1+ CD45R+, Bone marrow, avg-2 Immgen.org, GSE15907 5.492E-127 5.998E-125 4.785E-124 8.997E-124 104 402
16 fetal replicating Top 500 Cluster 1 fetal replicating Top 500 Cluster 1 Brain Map - Barres 3.344E-126 3.424E-124 2.732E-123 5.478E-123 93 267
17 fetal replicating Top 500 All fetal replicating Top 500 All Brain Map - Barres 3.108E-125 2.994E-123 2.389E-122 5.090E-122 109 496
18 GSM791105 500 Stem Cells, SC.MDP.BM, Sca1- Flt3+ MCSFR+ cKithi, Bone marrow, avg-3 Immgen.org, GSE15907 3.993E-125 3.633E-123 2.899E-122 6.540E-122 103 402
19 GSM538350 500 B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate CD45R- AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 5.466E-125 4.713E-123 3.760E-122 8.954E-122 104 418
20 GSM605781 500 gamma delta T cells, Tgd.vg1+vd6-.Th, TCRd+ Vg1.1+, Thymus, avg-3 Immgen.org, GSE15907 2.695E-123 2.207E-121 1.761E-120 4.414E-120 100 373
21 GSM538207 500 B cells, B.GC.Sp, CD19+ IgM+ IgD- GL7+ PNA+, Spleen, avg-3 Immgen.org, GSE15907 1.612E-120 1.257E-118 1.003E-117 2.640E-117 99 380
22 GSM605898 500 alpha beta T cells, T.8Eff.Sp.OT1.d6.LisOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 8.843E-118 6.584E-116 5.253E-115 1.448E-114 99 402
23 GSM791141 500 alpha beta T cells, preT.DN2B.Th, Lin-/lo CD25hi CD44+ cKitint, Thymus, avg-2 Immgen.org, GSE15907 1.148E-115 8.176E-114 6.523E-113 1.880E-112 99 420
24 GSM791114 500 Stem Cells, SC.CDP.BM, Sca1- Flt3+ MCSFR+ cKitlo, Bone marrow, avg-3 Immgen.org, GSE15907 2.762E-114 1.885E-112 1.504E-111 4.524E-111 97 401
25 GSM791154 500 alpha beta T cells, T.DN4.Th, Lin-/lo CD25- CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 1.072E-113 7.024E-112 5.604E-111 1.756E-110 95 376
26 GSM476658 500 gamma delta T cells, Tgd.vg2-24ahi.Th, TCRd+ Vg2- CD24+, Thymus, avg-2 Immgen.org, GSE15907 6.990E-112 4.404E-110 3.514E-109 1.145E-108 97 422
27 GSM538418 500 B cells, proB.FrBC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-1 Immgen.org, GSE15907 1.240E-104 7.525E-103 6.004E-102 2.032E-101 90 377
28 GSM538340 500 B cells, preB.FrD.FL, AA4.1+ IgM- CD19+ CD43- CD24+, Fetal Liver, avg-3 Immgen.org, GSE15907 2.420E-104 1.416E-102 1.130E-101 3.964E-101 91 395
29 GSM791149 500 alpha beta T cells, preT.DN3B.Th, Lin-/lo CD25hi CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 1.123E-100 6.344E-99 5.062E-98 1.840E-97 90 413
30 GSM538352 500 B cells, proB.FrA.BM, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Bone marrow, avg-2 Immgen.org, GSE15907 6.594E-100 3.600E-98 2.872E-97 1.080E-96 88 388
31 GSM476675 500 gamma delta T cells, Tgd.Th, TCRd+ CD3e+, Thymus, avg-3 Immgen.org, GSE15907 4.018E-99 2.123E-97 1.694E-96 6.582E-96 85 349
32 12Dn Top 500 All 12Dn Top 500 All Brain Map - Allen iN 3.194E-96 1.635E-94 1.305E-93 5.232E-93 92 495
33 Lungmap Mouse e16.5 Endothelial SubClass Proliferative Endothelial Top 500 All Mouse Lung E16.5 Proliferative Endothelial top500 Lungmap Mouse Single Cell (Lungmap.net) 4.220E-96 2.095E-94 1.671E-93 6.912E-93 89 442
34 Lungmap Mouse e16.5 Endothelial SubClass Proliferative Endothelial Top 500 Cluster 1 Mouse Lung E16.5 Endothelial Proliferative Endothelial c1 Lungmap Mouse Single Cell (Lungmap.net) 1.388E-93 6.689E-92 5.337E-91 2.274E-90 51 64
35 Lungmap Mouse e16.5 Epithelial SubClass Proliferative AT2 Progenitor Top 500 Cluster 0 Mouse Lung E16.5 Epithelial Proliferative AT2 Progenitor c0 Lungmap Mouse Single Cell (Lungmap.net) 1.240E-90 5.805E-89 4.632E-88 2.032E-87 46 50
36 GSM605793 500 gamma delta T cells, Tgd.vg2+24ahi.Th.TCRbko, TCRd+ Vg2+ CD24+, Thymus, avg-3 Immgen.org, GSE15907 2.074E-87 9.438E-86 7.531E-85 3.398E-84 82 412
37 GSM791126 500 Fetal Liver, SC.LTSL.FL, IgM- CD24- CD117+ IL7R- CD150+ CD48- AA4.1+ CD43+, Fetal Liver, avg-3 Immgen.org, GSE15907 2.152E-86 9.525E-85 7.600E-84 3.524E-83 82 423
38 GSM399397 100 alpha beta T cells, T.DPbl.Th, 4+ 8+ TCR-/lo FSChi, Thymus, avg-3 Immgen.org, GSE15907 1.154E-85 4.974E-84 3.968E-83 1.890E-82 53 90
39 GSM538338 500 alpha beta T cells, NKT.44-NK1.1-.Th, aGC CD1d tet CD3e, Thymus, avg-2 Immgen.org, GSE15907 1.807E-85 7.588E-84 6.055E-83 2.959E-82 80 398
40 GSM791131 500 B cells, MLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-3 Immgen.org, GSE15907 5.263E-83 2.155E-81 1.720E-80 8.620E-80 80 425
41 GSM538335 500 alpha beta T cells, NKT.44+NK1.1-.Th, aGC CD1d tet CD3 CD44, Thymus, avg-3 Immgen.org, GSE15907 3.540E-81 1.414E-79 1.128E-78 5.798E-78 77 392
42 GSM605773 500 alpha beta T cells, T.8.TI.B16, 4- 8+ TCR+ 45+, B16 Melanoma Tumor, avg-2 Immgen.org, GSE15907 1.838E-79 7.168E-78 5.719E-77 3.011E-76 74 359
43 GSM791108 500 Stem Cells, SC.MEP.BM, Lineage- Kit+ Sca1- CD34- FcgR-/low, Bone marrow, avg-2 Immgen.org, GSE15907 9.060E-79 3.451E-77 2.754E-76 1.484E-75 76 401
44 GSM399448 500 B cells, preB.FrD.BM, CD19+ IgM- CD45R+ CD43-, Bone marrow, avg-3 Immgen.org, GSE15907 1.038E-78 3.865E-77 3.084E-76 1.701E-75 75 384
45 GSM538354 500 B cells, proB.FrA.BM, AA4.1+ CD117+ IL7R+ CD45R+ CD24- CD19- IgM-, Bone marrow, avg-1 Immgen.org, GSE15907 6.492E-77 2.363E-75 1.885E-74 1.063E-73 69 304
46 GSM791122 500 Fetal Liver, SC.STSL.FL, IgM- CD24- CD117+ IL7R- CD150- CD48- AA4.1+ CD43+, Fetal Liver, avg-2 Immgen.org, GSE15907 2.041E-76 7.269E-75 5.800E-74 3.344E-73 75 410
47 GSM777030 500 B cells, B.Pl.AA4-.BM, CD138+ AA4.1- CD43+, Bone marrow, avg-2 Immgen.org, GSE15907 3.134E-76 1.092E-74 8.714E-74 5.133E-73 74 394
48 GSM399452 100 B cells, preB.FrC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-3 Immgen.org, GSE15907 6.544E-73 2.233E-71 1.782E-70 1.072E-69 47 88
49 GSM791110 500 Stem Cells, SC.MPP34F.BM, Lineage- cKit+ Sca-1+ flk2+ CD34+, Bone marrow, avg-2 Immgen.org, GSE15907 1.608E-72 5.377E-71 4.290E-70 2.635E-69 72 401
50 GSM791134 500 alpha beta T cells, preT.DN2-3.Th, Lin-/lo CD25hi CD44Int, Thymus, avg-2 Immgen.org, GSE15907 2.355E-68 7.714E-67 6.154E-66 3.857E-65 70 415
Show 45 more annotations

15: Computational [Display Chart] 386 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 54 Genes in module 54 MSigDb: C4 - CM: Cancer Modules 3.417E-105 1.319E-102 8.618E-102 1.319E-102 86 245
2 GNF2 CCNA2 Neighborhood of CCNA2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.932E-76 3.729E-74 2.436E-73 7.457E-74 47 62
3 GNF2 CDC20 Neighborhood of CDC20 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.594E-75 2.051E-73 1.340E-72 6.152E-73 44 52
4 GNF2 CCNB2 Neighborhood of CCNB2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 9.291E-75 8.966E-73 5.858E-72 3.586E-72 44 53
5 GNF2 CDC2 Neighborhood of CDC2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.666E-70 2.830E-68 1.849E-67 1.415E-67 43 56
6 GNF2 CENPF Neighborhood of CENPF MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.587E-63 4.237E-61 2.769E-60 2.542E-60 40 56
7 GNF2 HMMR Neighborhood of HMMR MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.887E-61 2.144E-59 1.401E-58 1.501E-58 36 43
8 GNF2 CENPE Neighborhood of CENPE MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.671E-58 2.736E-56 1.788E-55 2.189E-55 33 37
9 GNF2 RRM1 Neighborhood of RRM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.542E-55 2.377E-53 1.553E-52 2.139E-52 41 82
10 GNF2 ESPL1 Neighborhood of ESPL1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.349E-54 1.293E-52 8.446E-52 1.293E-51 31 35
11 GNF2 PCNA Neighborhood of PCNA MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.628E-53 5.712E-52 3.732E-51 6.283E-51 37 62
12 GNF2 RRM2 Neighborhood of RRM2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.110E-45 3.571E-44 2.333E-43 4.285E-43 28 36
13 GNF2 BUB1B Neighborhood of BUB1B MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.706E-45 1.397E-43 9.131E-43 1.817E-42 30 46
14 GNF2 MCM4 Neighborhood of MCM4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.137E-43 5.892E-42 3.850E-41 8.249E-41 30 50
15 GNF2 SMC4L1 Neighborhood of SMC4L1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.928E-43 7.534E-42 4.923E-41 1.130E-40 34 76
16 GNF2 MKI67 Neighborhood of MKI67 MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.739E-43 1.384E-41 9.047E-41 2.215E-40 24 26
17 GNF2 CKS2 Neighborhood of CKS2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.645E-41 8.276E-40 5.408E-39 1.407E-38 28 45
18 GNF2 SMC2L1 Neighborhood of SMC2L1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 9.995E-40 2.143E-38 1.400E-37 3.858E-37 24 30
19 GNF2 TTK Neighborhood of TTK MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.055E-39 2.143E-38 1.400E-37 4.071E-37 25 34
20 GNF2 H2AFX Neighborhood of H2AFX MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.341E-38 2.588E-37 1.691E-36 5.177E-36 23 28
21 GNF2 BUB1 Neighborhood of BUB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.545E-33 6.516E-32 4.257E-31 1.368E-30 20 25
22 GNF2 CKS1B Neighborhood of CKS1B MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.209E-30 7.384E-29 4.825E-28 1.625E-27 21 36
23 GNF2 FEN1 Neighborhood of FEN1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.126E-28 6.925E-27 4.525E-26 1.593E-25 22 49
24 GNF2 RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 5.109E-28 8.217E-27 5.369E-26 1.972E-25 23 57
25 GNF2 RFC3 Neighborhood of RFC3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.537E-25 2.374E-24 1.551E-23 5.935E-23 19 38
26 module 53 Genes in module 53 MSigDb: C4 - CM: Cancer Modules 2.957E-25 4.390E-24 2.869E-23 1.141E-22 42 391
27 module 397 Genes in module 397 MSigDb: C4 - CM: Cancer Modules 1.696E-21 2.424E-20 1.584E-19 6.545E-19 24 114
28 module 252 Genes in module 252 MSigDb: C4 - CM: Cancer Modules 1.431E-20 1.973E-19 1.289E-18 5.524E-18 30 227
29 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 4.321E-20 5.751E-19 3.758E-18 1.668E-17 37 395
30 module 198 Genes in module 198 MSigDb: C4 - CM: Cancer Modules 2.054E-19 2.620E-18 1.712E-17 7.928E-17 32 292
31 MORF BUB1 Neighborhood of BUB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.104E-19 2.620E-18 1.712E-17 8.123E-17 17 50
32 module 315 Genes in module 315 MSigDb: C4 - CM: Cancer Modules 6.984E-18 8.425E-17 5.505E-16 2.696E-15 11 15
33 module 403 Genes in module 403 MSigDb: C4 - CM: Cancer Modules 2.925E-17 3.421E-16 2.236E-15 1.129E-14 15 44
34 module 124 Genes in module 124 MSigDb: C4 - CM: Cancer Modules 5.102E-17 5.792E-16 3.785E-15 1.969E-14 19 92
35 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 1.643E-16 1.812E-15 1.184E-14 6.341E-14 34 419
36 MORF BUB1B Neighborhood of BUB1B MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.816E-16 3.020E-15 1.973E-14 1.087E-13 16 61
37 module 3 Genes in module 3 MSigDb: C4 - CM: Cancer Modules 3.524E-16 3.676E-15 2.402E-14 1.360E-13 32 375
38 module 98 Genes in module 98 MSigDb: C4 - CM: Cancer Modules 4.200E-15 4.266E-14 2.788E-13 1.621E-12 31 381
39 module 197 Genes in module 197 MSigDb: C4 - CM: Cancer Modules 4.796E-15 4.747E-14 3.102E-13 1.851E-12 22 170
40 module 57 Genes in module 57 MSigDb: C4 - CM: Cancer Modules 2.673E-14 2.580E-13 1.686E-12 1.032E-11 14 54
41 module 320 Genes in module 320 MSigDb: C4 - CM: Cancer Modules 6.328E-14 5.958E-13 3.893E-12 2.443E-11 10 20
42 module 451 Genes in module 451 MSigDb: C4 - CM: Cancer Modules 1.482E-13 1.362E-12 8.902E-12 5.722E-11 11 29
43 module 18 Genes in module 18 MSigDb: C4 - CM: Cancer Modules 1.693E-13 1.520E-12 9.931E-12 6.535E-11 31 436
44 module 126 Genes in module 126 MSigDb: C4 - CM: Cancer Modules 1.013E-12 8.885E-12 5.806E-11 3.909E-10 20 175
45 MORF ESPL1 Neighborhood of ESPL1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.801E-12 1.545E-11 1.009E-10 6.952E-10 13 58
46 module 244 Genes in module 244 MSigDb: C4 - CM: Cancer Modules 2.360E-12 1.980E-11 1.294E-10 9.110E-10 20 183
47 module 8 Genes in module 8 MSigDb: C4 - CM: Cancer Modules 3.766E-11 3.093E-10 2.021E-9 1.454E-8 27 406
48 module 17 Genes in module 17 MSigDb: C4 - CM: Cancer Modules 5.779E-11 4.647E-10 3.037E-9 2.231E-8 25 353
49 MORF RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.971E-10 1.552E-9 1.014E-8 7.606E-8 16 139
50 module 105 Genes in module 105 MSigDb: C4 - CM: Cancer Modules 4.944E-10 3.816E-9 2.494E-8 1.908E-7 18 194
Show 45 more annotations

16: MicroRNA [Display Chart] 925 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-24:miRTarbase hsa-miR-24:miRTarbase miRTarbase 2.112E-6 1.954E-3 1.447E-2 1.954E-3 6 38

17: Drug [Display Chart] 14877 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 D008154 Lucanthone CTD 5.090E-127 7.572E-123 7.712E-122 7.572E-123 87 212
2 C500026 palbociclib CTD 3.572E-126 2.657E-122 2.706E-121 5.314E-122 82 172
3 C488369 dasatinib CTD 8.591E-125 4.260E-121 4.339E-120 1.278E-120 106 472
4 D000069439 Dasatinib CTD 1.414E-124 5.258E-121 5.356E-120 2.103E-120 106 474
5 D007840 Latex CTD 3.732E-83 1.111E-79 1.131E-78 5.553E-79 63 190
6 5027 DN Etoposide [33419-42-0]; Down 200; 6.8uM; MCF7; HT HG-U133A Broad Institute CMAP 4.244E-81 1.052E-77 1.072E-76 6.314E-77 61 180
7 3317 DN Ciclopirox ethanolamine [41621-49-2]; Down 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 1.122E-67 2.384E-64 2.428E-63 1.669E-63 54 183
8 904 DN 5109870; Down 200; 25uM; MCF7; HT HG-U133A EA Broad Institute CMAP 6.368E-63 1.184E-59 1.206E-58 9.473E-59 51 179
9 C059765 amphotericin B, deoxycholate drug combination CTD 9.509E-56 1.572E-52 1.601E-51 1.415E-51 58 365
10 3241 DN Etoposide [33419-42-0]; Down 200; 6.8uM; MCF7; HT HG-U133A Broad Institute CMAP 3.140E-55 4.671E-52 4.758E-51 4.671E-51 47 185
11 5023 DN Ciclopirox ethanolamine [41621-49-2]; Down 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 5.535E-55 7.486E-52 7.625E-51 8.235E-51 47 187
12 5000 DN Amethopterin (R,S) [59-05-2]; Down 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP 1.968E-53 2.440E-50 2.485E-49 2.928E-49 46 186
13 5312 DN Monobenzone [103-16-2]; Down 200; 20uM; MCF7; HT HG-U133A Broad Institute CMAP 4.473E-53 5.119E-50 5.213E-49 6.654E-49 46 189
14 958 DN resveratrol; Down 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 5.270E-48 5.600E-45 5.704E-44 7.840E-44 42 176
15 C006551 2-amino-2-methyl-1-propanol CTD 6.204E-46 6.153E-43 6.267E-42 9.230E-42 50 342
16 3214 DN Amethopterin (R,S) [59-05-2]; Down 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP 5.511E-45 5.124E-42 5.219E-41 8.199E-41 41 189
17 622 DN resveratrol; Down 200; 50uM; MCF7; HG-U133A Broad Institute CMAP 2.579E-43 2.257E-40 2.299E-39 3.837E-39 40 190
18 841 DN resveratrol; Down 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 4.551E-43 3.761E-40 3.831E-39 6.771E-39 39 177
19 D048789 Phytoestrogens CTD 8.064E-39 6.314E-36 6.431E-35 1.200E-34 27 64
20 C496197 trans-10,cis-12-conjugated linoleic acid CTD 1.710E-38 1.272E-35 1.296E-34 2.544E-34 36 176
21 C058305 phenethyl isothiocyanate CTD 1.156E-37 8.190E-35 8.342E-34 1.720E-33 46 393
22 2041 DN Methotrexate [59-05-2]; Down 200; 8.8uM; HL60; HG-U133A Broad Institute CMAP 2.424E-34 1.639E-31 1.669E-30 3.606E-30 34 189
23 7389 DN 0173570-0000 [211245-44-2]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 2.225E-33 1.439E-30 1.466E-29 3.311E-29 33 183
24 CID000006623 bisphenol A Stitch 3.599E-33 2.231E-30 2.272E-29 5.355E-29 35 223
25 3559 DN Trifluridine [70-00-8]; Down 200; 13.6uM; MCF7; HT HG-U133A Broad Institute CMAP 2.023E-32 1.204E-29 1.226E-28 3.010E-28 33 195
26 D014747 Vinblastine CTD 4.291E-32 2.384E-29 2.428E-28 6.384E-28 36 260
27 5419 DN Methotrexate [59-05-2]; Down 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP 4.327E-32 2.384E-29 2.428E-28 6.437E-28 32 181
28 C063002 2,3-dimethoxy-1,4-naphthoquinone CTD 1.498E-31 7.961E-29 8.108E-28 2.229E-27 30 153
29 7176 DN Trifluridine [70-00-8]; Down 200; 13.6uM; MCF7; HT HG-U133A Broad Institute CMAP 8.000E-30 4.104E-27 4.180E-26 1.190E-25 31 192
30 595 DN resveratrol; Down 200; 50uM; MCF7; HG-U133A Broad Institute CMAP 1.012E-28 5.021E-26 5.114E-25 1.506E-24 30 188
31 6563 DN PNU-0293363 [326823-19-2]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 8.407E-27 4.034E-24 4.109E-23 1.251E-22 29 196
32 CID000004122 nocodazole Stitch 6.442E-26 2.995E-23 3.050E-22 9.584E-22 39 478
33 1715 DN Resveratrol [501-36-0]; Down 200; 17.6uM; HL60; HG-U133A Broad Institute CMAP 1.362E-25 6.138E-23 6.252E-22 2.026E-21 28 194
34 C010914 2,4-diaminotoluene CTD 1.804E-25 7.895E-23 8.041E-22 2.684E-21 30 240
35 1599 DN Amethopterin (R,S) [59-05-2]; Down 200; 8.8uM; HL60; HG-U133A Broad Institute CMAP 2.148E-24 9.132E-22 9.301E-21 3.196E-20 27 192
36 1791 DN Azaguanine-8 [134-58-7]; Down 200; 26.2uM; PC3; HT HG-U133A Broad Institute CMAP 1.882E-22 7.777E-20 7.921E-19 2.800E-18 25 181
37 5439 DN Pyrvinium pamoate [3546-41-6]; Down 200; 3.4uM; MCF7; HT HG-U133A Broad Institute CMAP 3.278E-22 1.318E-19 1.342E-18 4.877E-18 25 185
38 2865 DN Resveratrol [501-36-0]; Down 200; 17.6uM; MCF7; HT HG-U133A Broad Institute CMAP 8.384E-22 3.282E-19 3.343E-18 1.247E-17 25 192
39 573 DN deferoxamine mesylate salt; Down 200; 100uM; MCF7; HG-U133A Broad Institute CMAP 1.239E-21 4.727E-19 4.814E-18 1.844E-17 25 195
40 D016685 Mitomycin CTD 8.191E-21 3.046E-18 3.103E-17 1.219E-16 32 408
41 C072581 16-hydroxycleroda-3,13(14)-dien-15,16-olide CTD 6.547E-20 2.375E-17 2.419E-16 9.739E-16 13 28
42 C070081 fulvestrant CTD 7.091E-20 2.512E-17 2.558E-16 1.055E-15 33 473
43 3391 DN Monobenzone [103-16-2]; Down 200; 20uM; MCF7; HT HG-U133A Broad Institute CMAP 1.288E-19 4.455E-17 4.538E-16 1.916E-15 23 186
44 D002706 Chlordan CTD 1.445E-19 4.887E-17 4.978E-16 2.150E-15 18 89
45 2009 DN Verapamyl hydrochloride [152-11-4]; Down 200; 8.2uM; HL60; HG-U133A Broad Institute CMAP 3.387E-19 1.120E-16 1.141E-15 5.039E-15 23 194
46 1974 DN Pyrimethamine [58-14-0]; Down 200; 16uM; HL60; HG-U133A Broad Institute CMAP 3.503E-18 1.133E-15 1.154E-14 5.211E-14 22 190
47 D002509 Cephaloridine CTD 3.595E-18 1.138E-15 1.159E-14 5.348E-14 31 464
48 CID000003657 hydroxyurea Stitch 6.607E-18 2.048E-15 2.086E-14 9.829E-14 30 438
49 6136 DN Trifluridine [70-00-8]; Down 200; 13.6uM; HL60; HT HG-U133A Broad Institute CMAP 6.861E-17 2.058E-14 2.096E-13 1.021E-12 21 192
50 D004918 Erythromycin Estolate CTD 6.917E-17 2.058E-14 2.096E-13 1.029E-12 17 104
Show 45 more annotations

18: Disease [Display Chart] 1327 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C1134719 Invasive Ductal Breast Carcinoma DisGeNET Curated 3.477E-12 4.614E-9 3.584E-8 4.614E-9 19 228
2 umls:C0025958 Microcephaly DisGeNET Curated 9.610E-9 6.376E-6 4.953E-5 1.275E-5 13 155
3 umls:C0035335 Retinoblastoma DisGeNET Curated 4.339E-7 1.919E-4 1.491E-3 5.758E-4 19 463
4 umls:C3539878 Triple Negative Breast Neoplasms DisGeNET BeFree 1.551E-6 5.146E-4 3.997E-3 2.058E-3 18 456
5 umls:C0004135 Ataxia Telangiectasia DisGeNET Curated 7.321E-6 1.943E-3 1.509E-2 9.714E-3 11 196
6 umls:C0679427 myeloblastosis DisGeNET BeFree 1.093E-5 2.416E-3 1.877E-2 1.450E-2 4 14
7 umls:C1850343 MOSAIC VARIEGATED ANEUPLOIDY SYNDROME DisGeNET Curated 2.239E-5 4.204E-3 3.266E-2 2.971E-2 3 6
8 umls:C3711387 Autosomal Recessive Primary Microcephaly DisGeNET BeFree 2.534E-5 4.204E-3 3.266E-2 3.363E-2 4 17
9 umls:C0431350 Primary microcephaly DisGeNET Curated 3.232E-5 4.765E-3 3.702E-2 4.289E-2 4 18
10 umls:C0346156 Benign neoplasm of breast DisGeNET BeFree 7.476E-5 9.920E-3
7.706E-2
9.920E-2
 4 22
11 umls:C3469521 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) DisGeNET Curated 1.101E-4 1.328E-2
1.031E-1
1.460E-1
 10 219
12 umls:C0007138 Carcinoma, Transitional Cell DisGeNET Curated 1.285E-4 1.355E-2
1.052E-1
1.706E-1
 13 364
13 umls:C0005695 Bladder Neoplasm DisGeNET Curated 1.327E-4 1.355E-2
1.052E-1
1.761E-1
 12 316
14 umls:C0346153 Breast Cancer, Familial DisGeNET Curated 1.571E-4 1.489E-2
1.157E-1
2.085E-1
 8 146
15 umls:C0751690 Malignant Peripheral Nerve Sheath Tumor DisGeNET BeFree 1.981E-4 1.753E-2
1.361E-1
2.629E-1
 8 151
16 umls:C0279000 Liver and Intrahepatic Biliary Tract Carcinoma DisGeNET BeFree 2.438E-4 2.022E-2
1.570E-1
3.235E-1
 15 496
17 umls:C0015625 Fanconi Anemia DisGeNET Curated 2.736E-4 2.136E-2
1.659E-1
3.630E-1
 10 245
18 umls:C0342573 PITUITARY DWARFISM I DisGeNET Curated 4.751E-4 3.496E-2
2.716E-1
6.304E-1
 3 15
19 umls:C0220641 Lip and Oral Cavity Carcinoma DisGeNET BeFree 5.005E-4 3.496E-2
2.716E-1
6.642E-1
 13 419
20 umls:C0032460 Polycystic Ovary Syndrome DisGeNET Curated 5.579E-4 3.555E-2
2.762E-1
7.403E-1
 12 370
21 umls:C1335177 Ovarian Serous Adenocarcinoma DisGeNET BeFree 5.626E-4 3.555E-2
2.762E-1
7.466E-1
 5 64
22 umls:C3714644 Thymus Neoplasms DisGeNET BeFree 6.991E-4 4.217E-2
3.276E-1
9.277E-1
 3 17
23 umls:C0031117 Peripheral Neuropathy DisGeNET Curated 7.723E-4 4.456E-2
3.461E-1
1.000E0
 13 439
24 umls:C0023452 Leukemia, Lymphocytic, Acute, L1 DisGeNET Curated 8.269E-4 4.572E-2
3.552E-1
1.000E0
 12 387
Show 19 more annotations