Toppgene analysis for aggregated_1964_log, IC19, negative side

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1: GO: Molecular Function [Display Chart] 95 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043120 tumor necrosis factor binding 1.594E-3 3.785E-2
1.944E-1
1.514E-1
 1 2
2 GO:0004822 isoleucine-tRNA ligase activity 1.594E-3 3.785E-2
1.944E-1
1.514E-1
 1 2
3 GO:0004161 dimethylallyltranstransferase activity 1.594E-3 3.785E-2
1.944E-1
1.514E-1
 1 2
4 GO:0017129 triglyceride binding 1.594E-3 3.785E-2
1.944E-1
1.514E-1
 1 2
5 GO:0019959 interleukin-8 binding 2.389E-3 4.322E-2
2.220E-1
2.270E-1
 1 3
6 GO:0004337 geranyltranstransferase activity 3.185E-3 4.322E-2
2.220E-1
3.025E-1
 1 4
7 GO:0048403 brain-derived neurotrophic factor binding 3.185E-3 4.322E-2
2.220E-1
3.025E-1
 1 4
8 GO:0004311 farnesyltranstransferase activity 4.774E-3 4.407E-2
2.264E-1
4.535E-1
 1 6
9 GO:0019838 growth factor binding 5.566E-3 4.407E-2
2.264E-1
5.288E-1
 2 142
10 GO:0019958 C-X-C chemokine binding 5.567E-3 4.407E-2
2.264E-1
5.289E-1
 1 7
11 GO:0048406 nerve growth factor binding 5.567E-3 4.407E-2
2.264E-1
5.289E-1
 1 7
12 GO:0008479 queuine tRNA-ribosyltransferase activity 5.567E-3 4.407E-2
2.264E-1
5.289E-1
 1 7
13 GO:0004465 lipoprotein lipase activity 6.360E-3 4.605E-2
2.365E-1
6.042E-1
 1 8
14 GO:0019966 interleukin-1 binding 7.152E-3 4.605E-2
2.365E-1
6.795E-1
 1 9
15 GO:0052689 carboxylic ester hydrolase activity 7.270E-3 4.605E-2
2.365E-1
6.907E-1
 2 163
16 GO:0072509 divalent inorganic cation transmembrane transporter activity 8.155E-3 4.842E-2
2.487E-1
7.747E-1
 2 173
17 GO:0043121 neurotrophin binding 8.735E-3 4.881E-2
2.507E-1
8.298E-1
 1 11
Show 12 more annotations

2: GO: Biological Process [Display Chart] 593 annotations before applied cutoff / 18785 genes in category

No results to display

3: GO: Cellular Component [Display Chart] 61 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0044295 axonal growth cone 2.292E-4 7.749E-3 3.639E-2 1.398E-2 2 29
2 GO:0030426 growth cone 3.520E-4 7.749E-3 3.639E-2 2.147E-2 3 182
3 GO:0030427 site of polarized growth 3.811E-4 7.749E-3 3.639E-2 2.325E-2 3 187
4 GO:0072534 perineuronal net 2.345E-3 3.432E-2
1.612E-1
1.431E-1
 1 3
5 GO:0030175 filopodium 2.813E-3 3.432E-2
1.612E-1
1.716E-1
 2 102
6 GO:0031012 extracellular matrix 4.562E-3 4.638E-2
2.178E-1
2.783E-1
 3 444
7 GO:0043197 dendritic spine 6.127E-3 4.792E-2
2.250E-1
3.738E-1
 2 152
8 GO:0044309 neuron spine 6.285E-3 4.792E-2
2.250E-1
3.834E-1
 2 154
Show 3 more annotations

4: Human Phenotype [Display Chart] 34 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0012238 Hyperchylomicronemia 2.720E-3 3.079E-2
1.268E-1
9.246E-2
 1 2
2 HP:0005202 Helicobacter pylori infection 2.720E-3 3.079E-2
1.268E-1
9.246E-2
 1 2
3 HP:0008356 Combined hyperlipidemia 2.720E-3 3.079E-2
1.268E-1
9.246E-2
 1 2
4 HP:0002574 Episodic abdominal pain 4.077E-3 3.079E-2
1.268E-1
1.386E-1
 1 3
5 HP:0001013 Eruptive xanthomas 5.433E-3 3.079E-2
1.268E-1
1.847E-1
 1 4
6 HP:0005268 Spontaneous abortion 5.433E-3 3.079E-2
1.268E-1
1.847E-1
 1 4
7 HP:0000660 Lipemia retinalis 6.787E-3 3.297E-2
1.358E-1
2.308E-1
 1 5
Show 2 more annotations

5: Mouse Phenotype [Display Chart] 363 annotations before applied cutoff / 9299 genes in category

No results to display

6: Domain [Display Chart] 158 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR031256 Myelin P2 InterPro 8.006E-4 1.807E-2
1.020E-1
1.265E-1
 1 1
2 IPR033709 Anticodon Ile ABEc InterPro 8.006E-4 1.807E-2
1.020E-1
1.265E-1
 1 1
3 IPR023586 Ile-tRNA-ligase type2 InterPro 8.006E-4 1.807E-2
1.020E-1
1.265E-1
 1 1
4 IPR004803 Queuine tRNA-ribosylTrfase InterPro 8.006E-4 1.807E-2
1.020E-1
1.265E-1
 1 1
5 IPR028806 RBM6 InterPro 8.006E-4 1.807E-2
1.020E-1
1.265E-1
 1 1
6 IPR010916 TonB box CS InterPro 8.006E-4 1.807E-2
1.020E-1
1.265E-1
 1 1
7 IPR008050 MCM7 InterPro 8.006E-4 1.807E-2
1.020E-1
1.265E-1
 1 1
8 IPR002330 Lipo Lipase InterPro 1.601E-3 1.882E-2
1.062E-1
2.529E-1
 1 2
9 IPR002616 tRNA ribo trans-like InterPro 1.601E-3 1.882E-2
1.062E-1
2.529E-1
 1 2
10 IPR002301 Ile-tRNA-ligase InterPro 1.601E-3 1.882E-2
1.062E-1
2.529E-1
 1 2
11 PF01702 TGT Pfam 1.601E-3 1.882E-2
1.062E-1
2.529E-1
 1 2
12 3.20.20.105 - Gene3D 1.601E-3 1.882E-2
1.062E-1
2.529E-1
 1 2
13 PF01275 Myelin PLP Pfam 2.400E-3 1.882E-2
1.062E-1
3.792E-1
 1 3
14 IPR018237 Myelin PLP CS InterPro 2.400E-3 1.882E-2
1.062E-1
3.792E-1
 1 3
15 IPR001614 Myelin PLP InterPro 2.400E-3 1.882E-2
1.062E-1
3.792E-1
 1 3
16 IPR015451 Cyclin D InterPro 2.400E-3 1.882E-2
1.062E-1
3.792E-1
 1 3
17 PS01004 MYELIN PLP 2 PROSITE 2.400E-3 1.882E-2
1.062E-1
3.792E-1
 1 3
18 PS00575 MYELIN PLP 1 PROSITE 2.400E-3 1.882E-2
1.062E-1
3.792E-1
 1 3
19 IPR033749 Polyprenyl synt CS InterPro 2.400E-3 1.882E-2
1.062E-1
3.792E-1
 1 3
20 SM00002 PLP SMART 2.400E-3 1.882E-2
1.062E-1
3.792E-1
 1 3
21 PF00348 polyprenyl synt Pfam 3.199E-3 1.882E-2
1.062E-1
5.054E-1
 1 4
22 IPR000092 Polyprenyl synt InterPro 3.199E-3 1.882E-2
1.062E-1
5.054E-1
 1 4
23 PS00444 POLYPRENYL SYNTHASE 2 PROSITE 3.199E-3 1.882E-2
1.062E-1
5.054E-1
 1 4
24 PS00723 POLYPRENYL SYNTHASE 1 PROSITE 3.199E-3 1.882E-2
1.062E-1
5.054E-1
 1 4
25 PF08264 Anticodon 1 Pfam 4.795E-3 1.882E-2
1.062E-1
7.576E-1
 1 6
26 PF14551 MCM N Pfam 4.795E-3 1.882E-2
1.062E-1
7.576E-1
 1 6
27 IPR013155 M/V/L/I-tRNA-synth anticd-bd InterPro 4.795E-3 1.882E-2
1.062E-1
7.576E-1
 1 6
28 IPR018525 MCM CS InterPro 4.795E-3 1.882E-2
1.062E-1
7.576E-1
 1 6
29 1.10.600.10 - Gene3D 4.795E-3 1.882E-2
1.062E-1
7.576E-1
 1 6
30 3.90.740.10 - Gene3D 4.795E-3 1.882E-2
1.062E-1
7.576E-1
 1 6
31 IPR009008 Val/Leu/Ile-tRNA-synth edit InterPro 4.795E-3 1.882E-2
1.062E-1
7.576E-1
 1 6
32 IPR027925 MCM N InterPro 4.795E-3 1.882E-2
1.062E-1
7.576E-1
 1 6
33 PF00133 tRNA-synt 1 Pfam 5.592E-3 1.882E-2
1.062E-1
8.835E-1
 1 7
34 IPR002300 aa-tRNA-synth Ia InterPro 5.592E-3 1.882E-2
1.062E-1
8.835E-1
 1 7
35 IPR019742 MacrogloblnA2 CS InterPro 6.388E-3 1.882E-2
1.062E-1
1.000E0
 1 8
36 PF17207 MCM OB Pfam 6.388E-3 1.882E-2
1.062E-1
1.000E0
 1 8
37 2.60.40.690 - Gene3D 6.388E-3 1.882E-2
1.062E-1
1.000E0
 1 8
38 IPR033762 MCM OB InterPro 6.388E-3 1.882E-2
1.062E-1
1.000E0
 1 8
39 IPR019565 MacrogloblnA2 thiol-ester-bond InterPro 6.388E-3 1.882E-2
1.062E-1
1.000E0
 1 8
40 PS00847 MCM 1 PROSITE 6.388E-3 1.882E-2
1.062E-1
1.000E0
 1 8
41 SM01360 A2M SMART 6.388E-3 1.882E-2
1.062E-1
1.000E0
 1 8
42 PF10569 Thiol-ester cl Pfam 6.388E-3 1.882E-2
1.062E-1
1.000E0
 1 8
43 PS50051 MCM 2 PROSITE 6.388E-3 1.882E-2
1.062E-1
1.000E0
 1 8
44 SM01361 A2M recep SMART 6.388E-3 1.882E-2
1.062E-1
1.000E0
 1 8
45 SM01359 A2M N 2 SMART 6.388E-3 1.882E-2
1.062E-1
1.000E0
 1 8
46 SM00350 MCM SMART 7.184E-3 1.882E-2
1.062E-1
1.000E0
 1 9
47 IPR001208 MCM dom InterPro 7.184E-3 1.882E-2
1.062E-1
1.000E0
 1 9
48 IPR008949 Isoprenoid synthase dom InterPro 7.184E-3 1.882E-2
1.062E-1
1.000E0
 1 9
49 IPR031327 MCM InterPro 7.184E-3 1.882E-2
1.062E-1
1.000E0
 1 9
50 PF00493 MCM Pfam 7.184E-3 1.882E-2
1.062E-1
1.000E0
 1 9
Show 45 more annotations

7: Pathway [Display Chart] 149 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PW:0000015 Alzheimer disease Pathway Ontology 1.652E-4 1.807E-2
1.009E-1
 2.462E-2 2 24
2 106156 Lipoprotein metabolism BioSystems: REACTOME 2.425E-4 1.807E-2
1.009E-1
 3.614E-2 2 29
3 106111 Lipid digestion, mobilization, and transport BioSystems: REACTOME 6.965E-4 3.071E-2
1.715E-1
1.038E-1
 2 49
4 PW:0000023 immune response Pathway Ontology 8.245E-4 3.071E-2
1.715E-1
1.228E-1
 1 1
5 219802 SREBP signalling BioSystems: WikiPathways 1.186E-3 3.323E-2
1.856E-1
1.768E-1
 2 64
6 198805 G1 to S cell cycle control BioSystems: WikiPathways 1.338E-3 3.323E-2
1.856E-1
1.994E-1
 2 68
7 PW:0000024 inflammatory response Pathway Ontology 1.648E-3 3.509E-2
1.959E-1
2.456E-1
 1 2
8 198827 DNA damage response (only ATM dependent) BioSystems: WikiPathways 2.382E-3 4.078E-2
2.278E-1
3.549E-1
 2 91
9 198811 Cell cycle BioSystems: WikiPathways 2.982E-3 4.078E-2
2.278E-1
4.444E-1
 2 102
10 PW:0000184 terpenoid biosynthetic Pathway Ontology 3.294E-3 4.078E-2
2.278E-1
4.908E-1
 1 4
11 PW:0000010 lipid metabolic Pathway Ontology 3.294E-3 4.078E-2
2.278E-1
4.908E-1
 1 4
12 142221 trans, trans-farnesyl diphosphate biosynthesis BioSystems: BIOCYC 3.294E-3 4.078E-2
2.278E-1
4.908E-1
 1 4
13 83054 Cell cycle BioSystems: KEGG 4.374E-3 4.078E-2
2.278E-1
6.517E-1
 2 124
14 P05726 2-arachidonoylglycerol biosynthesis PantherDB 4.938E-3 4.078E-2
2.278E-1
7.357E-1
 1 6
15 160941 Mitotic G1-G1/S phases BioSystems: REACTOME 5.466E-3 4.078E-2
2.278E-1
8.144E-1
 2 139
16 198909 B Cell Receptor Signaling Pathway BioSystems: WikiPathways 7.097E-3 4.078E-2
2.278E-1
1.000E0
 2 159
17 SMP00383 Obesity / Metabolic Syndrome SMPDB 7.399E-3 4.078E-2
2.278E-1
1.000E0
 1 9
18 PW:0000248 steroid biosynthetic Pathway Ontology 7.399E-3 4.078E-2
2.278E-1
1.000E0
 1 9
19 920989 miRNA Regulation of DNA Damage Response BioSystems: WikiPathways 7.399E-3 4.078E-2
2.278E-1
1.000E0
 1 9
20 161069 Zinc influx into cells by the SLC39 gene family BioSystems: REACTOME 8.218E-3 4.078E-2
2.278E-1
1.000E0
 1 10
21 MAP00100 Sterol biosynthesis MAP00100 Sterol biosynthesis GenMAPP 8.218E-3 4.078E-2
2.278E-1
1.000E0
 1 10
22 523016 Transcriptional misregulation in cancer BioSystems: KEGG 8.924E-3 4.078E-2
2.278E-1
1.000E0
 2 179
23 P00014 Cholesterol biosynthesis PantherDB 9.036E-3 4.078E-2
2.278E-1
1.000E0
 1 11
24 105790 Unwinding of DNA BioSystems: REACTOME 9.036E-3 4.078E-2
2.278E-1
1.000E0
 1 11
25 SMP00099 Lovastatin Pathway SMPDB 9.854E-3 4.078E-2
2.278E-1
1.000E0
 1 12
26 SMP00089 Pravastatin Pathway SMPDB 9.854E-3 4.078E-2
2.278E-1
1.000E0
 1 12
27 SMP00039 Glycerolipid Metabolism SMPDB 9.854E-3 4.078E-2
2.278E-1
1.000E0
 1 12
28 SMP00131 Atorvastatin Pathway SMPDB 9.854E-3 4.078E-2
2.278E-1
1.000E0
 1 12
29 SMP00119 Fluvastatin Pathway SMPDB 9.854E-3 4.078E-2
2.278E-1
1.000E0
 1 12
30 SMP00111 Cerivastatin Pathway SMPDB 9.854E-3 4.078E-2
2.278E-1
1.000E0
 1 12
31 SMP00112 Risedronate Pathway SMPDB 9.854E-3 4.078E-2
2.278E-1
1.000E0
 1 12
32 SMP00092 Rosuvastatin Pathway SMPDB 9.854E-3 4.078E-2
2.278E-1
1.000E0
 1 12
33 SMP00079 Ibandronate Pathway SMPDB 9.854E-3 4.078E-2
2.278E-1
1.000E0
 1 12
34 SMP00107 Zoledronate Pathway SMPDB 9.854E-3 4.078E-2
2.278E-1
1.000E0
 1 12
35 SMP00117 Pamidronate Pathway SMPDB 9.854E-3 4.078E-2
2.278E-1
1.000E0
 1 12
36 SMP00095 Alendronate pathway SMPDB 9.854E-3 4.078E-2
2.278E-1
1.000E0
 1 12
37 PW:0000482 lipoprotein metabolic Pathway Ontology 1.067E-2 4.184E-2
2.337E-1
1.000E0
 1 13
38 545288 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) BioSystems: BIOCYC 1.067E-2 4.184E-2
2.337E-1
1.000E0
 1 13
39 106158 HDL-mediated lipid transport BioSystems: REACTOME 1.230E-2 4.583E-2
2.559E-1
1.000E0
 1 15
40 P00013 Cell cycle PantherDB 1.230E-2 4.583E-2
2.559E-1
1.000E0
 1 15
41 161067 Zinc transporters BioSystems: REACTOME 1.393E-2 4.676E-2
2.611E-1
1.000E0
 1 17
42 198809 Cholesterol biosynthesis BioSystems: WikiPathways 1.393E-2 4.676E-2
2.611E-1
1.000E0
 1 17
43 106157 Chylomicron-mediated lipid transport BioSystems: REACTOME 1.393E-2 4.676E-2
2.611E-1
1.000E0
 1 17
44 106059 Intrinsic Pathway BioSystems: REACTOME 1.393E-2 4.676E-2
2.611E-1
1.000E0
 1 17
45 MAP00970 Aminoacyl tRNA biosynthesis MAP00970 Aminoacyl tRNA biosynthesis GenMAPP 1.475E-2 4.676E-2
2.611E-1
1.000E0
 1 18
46 PW:0000454 cholesterol biosynthetic Pathway Ontology 1.475E-2 4.676E-2
2.611E-1
1.000E0
 1 18
47 M6682 CDK Regulation of DNA Replication MSigDB C2 BIOCARTA (v5.1) 1.475E-2 4.676E-2
2.611E-1
1.000E0
 1 18
48 672464 SRF and miRs in Smooth Muscle Differentiation and Proliferation BioSystems: WikiPathways 1.556E-2 4.831E-2
2.698E-1
1.000E0
 1 19
Show 43 more annotations

8: Pubmed [Display Chart] 2912 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19929250:gr The FoxO/Bcl-6/cyclin D2 pathway mediates metabolic and growth factor stimulation of proliferation in Min6 pancreatic beta-cells. GeneRIF 2.677E-7 1.949E-4 1.667E-3 7.797E-4 2 3
2 26986233 Overexpression of miR-155 promotes the proliferation and invasion of oral squamous carcinoma cells by regulating BCL6/cyclin D2. Pubmed 2.677E-7 1.949E-4 1.667E-3 7.797E-4 2 3
3 15509806:gr FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. GeneRIF 2.677E-7 1.949E-4 1.667E-3 7.797E-4 2 3
4 15509806 FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. Pubmed 2.677E-7 1.949E-4 1.667E-3 7.797E-4 2 3
5 15531890 Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Pubmed 8.921E-7 5.196E-4 4.445E-3 2.598E-3 2 5
6 18660489:gr Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. GeneRIF 5.920E-5 7.532E-4 6.443E-3
1.724E-1
 3 250
7 18660489 Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. Pubmed 5.920E-5 7.532E-4 6.443E-3
1.724E-1
 3 250
8 11534394:gr [HindIII polymorphism of lipoprotein lipase gene and risk of myocardial infarction]. GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
9 18854511:gr Fertility in a i(Xq) Klinefelter patient: importance of XIST expression level determined by qRT-PCR in ruling out Klinefelter cryptic mosaicism as cause of oligozoospermia. GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
10 11730816:gr Influence of lipoprotein lipase serine 447 stop polymorphism on tracking of triglycerides and HDL cholesterol from childhood to adulthood and familial risk of coronary artery disease: the Bogalusa heart study. GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
11 8636206 XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
12 16431216 A novel substitution at the translation initiator codon (ATG-->ATC) of the lipoprotein lipase gene is mainly responsible for lipoprotein lipase deficiency in a patient with severe hypertriglyceridemia and recurrent pancreatitis. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
13 16772602 High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
14 15253101:gr Lipoprotein lipase gene polymorphisms and blood pressure levels in the Northern Chinese Han population. GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
15 21619671 Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
16 19577536 Restoration of cyclin D2 has an inhibitory potential on the proliferation of LNCaP cells. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
17 17967834 Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
18 21971609 Diagnostic value of multiple biomarker panel for prediction of significant fibrosis in chronic hepatitis C. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
19 17030583 Clustering of Helicobacter pylori VacA in lipid rafts, mediated by its receptor, receptor-like protein tyrosine phosphatase beta, is required for intoxication in AZ-521 Cells. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
20 21854610:gr Lipoprotein lipase S447X variant associated with VLDL, LDL and HDL diameter clustering in the MetS. GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
21 16451134 Functional variants of the lipoprotein lipase gene and the risk of preeclampsia among non-Hispanic Caucasian women. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
22 11605530:gr [Connection of HindIII-polymorphism in the lipoprotein lipase gene with myocardial infarct and life span in elderly ischemic heart disease patients]. GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
23 12297480 Expression of trophinin in the cycling endometrium and its association with infertility. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
24 9441757 Subregional localization of 21 chromosome 7-specific expressed sequence tags (ESTs) by FISH using newly identified YACs and P1s. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
25 21862952 Association between schizophrenia and single nucleotide polymorphisms in lipoprotein lipase gene in a Han Chinese population. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
26 20473882 Gene expression profile changes and possible molecular subtypes in differentiated-type nonkeratinizing nasopharyngeal carcinoma. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
27 8274736 Molecular cloning of the breakpoint for 3q27 translocation in B-cell lymphomas and leukemias. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
28 16489068:gr Comparison of the expression and prognostic significance of differentiation markers between diffuse large B-cell lymphoma of central nervous system origin and peripheral nodal origin. GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
29 11140837 The common mutations in the lipoprotein lipase gene in Italy: effects on plasma lipids and angiographically assessed coronary atherosclerosis. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
30 12866915 Genetics of the lipoprotein lipase gene and hypertriglyceridaemia. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
31 18175800:gr Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype? GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
32 18765529:gr Overexpression of the zinc uptake transporter hZIP1 inhibits nuclear factor-kappaB and reduces the malignant potential of prostate cancer cells in vitro and in vivo. GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
33 20596061 Meta-based association of the lipoprotein lipase gene S447X variant with hypertension and blood pressure variation. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
34 17403113:gr Role of elevated alpha2-macroglobulin revisited: results of a case-control study in children with symptomatic thromboembolism. GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
35 22253048:gr Microglial zinc uptake via zinc transporters induces ATP release and the activation of microglia. GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
36 18521193:gr Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer. GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
37 17681919 [Association of Hind RFLP in lipoprotein lipase gene with type 2 diabetes]. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
38 19295657:gr Novel LPL mutations associated with lipoprotein lipase deficiency: two case reports and a literature review. GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
39 16029634 [The effect of lipoprotein lipase (LPL) polymorphism on plasma LPL concentration and triglyceride]. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
40 14550576:gr Conditional expression of MCM7 increases tumor growth without altering DNA replication activity. GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
41 18223635 Higher post-absorptive skeletal muscle LPL activity in African American vs. non-Hispanic White pre-menopausal women. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
42 16489068 Comparison of the expression and prognostic significance of differentiation markers between diffuse large B-cell lymphoma of central nervous system origin and peripheral nodal origin. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
43 15720416 Replicative MCM7 protein as a proliferation marker in endometrial carcinoma: a tissue microarray and clinicopathological analysis. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
44 11901360 Alpha2-macroglobulin exon 24 (Val-1000-Ile) polymorphism is not associated with late-onset sporadic Alzheimer's dementia in the Hungarian population. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
45 17058522:gr Association of two genetic variations of lipoprotein lipase, S447X and Hind III, with coronary artery disease and hypertriglyceridemia. GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
46 18635970 Distinct proliferative and transcriptional effects of the D-type cyclins in vivo. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
47 22456526:gr Prognostic significance of MCM7 expression in the bronchial brushings of patients with non-small cell lung cancer (NSCLC). GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
48 16755277:gr Haplotypes in the lipoprotein lipase gene influence high-density lipoprotein cholesterol response to statin therapy and progression of atherosclerosis in coronary artery bypass grafts. GeneRIF 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
49 2038366 A mutation in the human lipoprotein lipase gene as the most common cause of familial chylomicronemia in French Canadians. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
50 21541797 Characterization of a novel positive transcription regulatory element that differentially regulates the alpha-2-macroglobulin gene in replicative senescence. Pubmed 3.086E-4 7.532E-4 6.443E-3
8.985E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 606 annotations before applied cutoff / 16534 genes in category

No results to display

10: Cytoband [Display Chart] 16 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 8q21.3-q22.1 8q21.3-q22.1 4.616E-4 7.386E-3 2.497E-2 7.386E-3 1 1
2 Xp11.22-p11.21 Xp11.22-p11.21 1.845E-3 8.853E-3 2.993E-2 2.952E-2 1 4
3 20p11 20p11 2.306E-3 8.853E-3 2.993E-2 3.690E-2 1 5
4 4q34 4q34 2.306E-3 8.853E-3 2.993E-2 3.690E-2 1 5
5 7q21.3-q22.1 7q21.3-q22.1 2.767E-3 8.853E-3 2.993E-2 4.427E-2 1 6
6 9q21 9q21 5.067E-3 1.351E-2 4.568E-2
8.107E-2
 1 11
7 7q31.3 7q31.3 6.903E-3 1.578E-2
5.334E-2
1.105E-1
 1 15
8 3q27 3q27 1.148E-2 2.296E-2
7.763E-2
1.837E-1
 1 25
9 Xq13.2 Xq13.2 1.876E-2 3.002E-2
1.015E-1
3.002E-1
 1 41
10 8p22 8p22 1.876E-2 3.002E-2
1.015E-1
3.002E-1
 1 41
11 1q22 1q22 2.600E-2 3.646E-2
1.233E-1
4.159E-1
 1 57
12 3p21.3 3p21.3 2.735E-2 3.646E-2
1.233E-1
4.375E-1
 1 60
13 12p13 12p13 3.004E-2 3.697E-2
1.250E-1
4.807E-1
 1 66
14 12p13.31 12p13.31 3.764E-2 4.302E-2
1.454E-1
6.023E-1
 1 83
15 1q21 1q21 4.209E-2 4.489E-2
1.518E-1
6.734E-1
 1 93
Show 10 more annotations

11: Transcription Factor Binding Site [Display Chart] 229 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 15 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 555 Fibronectin type III domain containing|Immunoglobulin like domain containing genenames.org 5.625E-3 2.927E-2
9.713E-2
8.438E-2
 2 160
2 1085 MCM family genenames.org 6.414E-3 2.927E-2
9.713E-2
9.621E-2
 1 9
3 1234 Complement system|Endogenous ligands|C3 and PZP like, alpha-2-macroglobulin domain containing genenames.org 6.414E-3 2.927E-2
9.713E-2
9.621E-2
 1 9
4 550 Fatty acid binding protein family genenames.org 1.138E-2 2.927E-2
9.713E-2
1.706E-1
 1 16
5 131 Aminoacyl tRNA synthetases, Class I genenames.org 1.350E-2 2.927E-2
9.713E-2
2.024E-1
 1 19
6 813 Protein tyrosine phosphatases, receptor type genenames.org 1.491E-2 2.927E-2
9.713E-2
2.236E-1
 1 21
7 579 G-patch domain containing|Minor histocompatibility antigens genenames.org 1.561E-2 2.927E-2
9.713E-2
2.342E-1
 1 22
8 464 Lipases genenames.org 1.561E-2 2.927E-2
9.713E-2
2.342E-1
 1 22
9 473 Cyclins|Mediator complex genenames.org 2.053E-2 3.422E-2
1.135E-1
3.080E-1
 1 29
10 1136 MAGE family genenames.org 2.822E-2 4.232E-2
1.404E-1
4.232E-1
 1 40
Show 5 more annotations

13: Coexpression [Display Chart] 1760 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M4562 Genes up-regulated during in vitro maturation of CD14+ [GeneID=929] monocytes (day 0) into immature (day 7) and mature dendritic cells (day 14). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.215E-6 2.138E-3 1.721E-2 2.138E-3 4 114
2 M2892 Genes up-regulated in epithelial kidney cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v5.1) 3.002E-6 2.642E-3 2.127E-2 5.284E-3 4 143
3 M1844 Up-regulated genes in breast tumors from transgenic mice overexpressing ERBB2 and CDC25A [GeneID=2064;993] compared to those from mice overexpressing ERBB2 only. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.595E-5 2.062E-2
1.660E-1
9.847E-2
 3 104
4 M16021 Genes from the 12p region that up-regulated in teratoma cells compared to normal testis. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.987E-5 2.062E-2
1.660E-1
1.054E-1
 2 16
5 M7079 The 'core ESC-like gene module': genes coordinately up-regulated in a compendium of mouse embryonic stem cells (ESC) which are shared with the human ESC-like module. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.513E-5 2.062E-2
1.660E-1
1.498E-1
 4 335
6 M7184 Genes up-regulated in glioblastoma cell lines displaying spherical growth (cluster-1) compared to those displaying semiadherent or adherent growth phenotype (cluster-2). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.046E-4 2.062E-2
1.660E-1
1.840E-1
 2 21
7 M18608 Selected genes up-regulated in WT-A10 cells (gastric epithelium) expressing the H. pilori virulence gene CagA. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.372E-4 2.062E-2
1.660E-1
2.415E-1
 2 24
8 M5955 Genes up-regulated in 293T (transformed fetal renal cell) upon expression of MYC [GeneID=4609]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.491E-4 2.062E-2
1.660E-1
2.624E-1
 2 25
9 M18077 Genes up-regulated in immunoglobulin light chain amyloidosis plasma cells (ALPC) compared to multiple myeloma (MM) cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.615E-4 2.062E-2
1.660E-1
2.842E-1
 2 26
10 M1484 Genes up-regulated in pancreatic cells from mice with double knockout of E2F1 [GeneID=1869] and E2F2 [GeneID=1870] compared to wild type. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.692E-4 2.062E-2
1.660E-1
2.978E-1
 3 151
11 M988 Genes up-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.759E-4 2.062E-2
1.660E-1
3.096E-1
 3 153
12 M2715 Genes down-regulated in MEF cells (embryonic fibroblasts) with knockout of SNF5 [Gene ID=6598] gene. MSigDB C6: Oncogenic Signatures (v5.1) 2.082E-4 2.062E-2
1.660E-1
3.665E-1
 3 162
13 M1500 Strongly down-regulated at 8-48 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.158E-4 2.062E-2
1.660E-1
3.797E-1
 2 30
14 GSE14415 ACT VS CTRL NATURAL TREG DN Genes down-regulated in natural T reg: activated versus naïve. MSigDB C7: Immunologic Signatures (v5.1) 2.159E-4 2.062E-2
1.660E-1
3.800E-1
 3 164
15 M15981 Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.225E-4 2.062E-2
1.660E-1
3.915E-1
 4 430
16 M17990 Genes from cluster 2: down-regulated in group C of tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609] in plasma cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.458E-4 2.062E-2
1.660E-1
4.326E-1
 2 32
17 M11850 Genes up-regulated in WI-38 cells (senescent primary fibroblasts) after inactivation of TP53 [GeneID=7157] by GSE56 polypeptide. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.615E-4 2.062E-2
1.660E-1
4.603E-1
 2 33
18 M7409 Genes highly expressed in the neonatal hippocampus (clusters 4 and 8). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.945E-4 2.062E-2
1.660E-1
5.183E-1
 2 35
19 M5944 Genes up-regulated during formation of blood vessels (angiogenesis). MSigDB H: Hallmark Gene Sets (v5.1) 3.117E-4 2.062E-2
1.660E-1
5.485E-1
 2 36
20 M3898 Genes down-regulated in NHEK cells (normal epidermal keratinocytes) after UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.519E-4 2.062E-2
1.660E-1
6.194E-1
 4 485
21 M3287 Genes up-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) versus PBMC 7 days after stimulation with YF17D vaccine. MSigDB C7: Immunologic Signatures (v5.1) 3.590E-4 2.062E-2
1.660E-1
6.318E-1
 3 195
22 GSE21670 STAT3 KO VS WT CD4 TCELL DN Genes down-regulated in CD4 [GeneID=920] T cells: STAT3 [GeneID=6774] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v5.1) 3.699E-4 2.062E-2
1.660E-1
6.509E-1
 3 197
23 GSE32986 UNSTIM VS CURDLAN LOWDOSE STIM DC DN Genes down-regulated in bone marrow-derived dendritic cells: unstimulated versus low dose of 1,3-beta-D-oligoglucan [PubChem=11375554]. MSigDB C7: Immunologic Signatures (v5.1) 3.810E-4 2.062E-2
1.660E-1
6.705E-1
 3 199
24 M4787 Genes up-regulated in comparison of lineage negative versus NKT cells. MSigDB C7: Immunologic Signatures (v5.1) 3.866E-4 2.062E-2
1.660E-1
6.804E-1
 3 200
25 M3199 Genes down-regulated in comparison of naive B cell versus pre-germinal tonsil B cells. MSigDB C7: Immunologic Signatures (v5.1) 3.866E-4 2.062E-2
1.660E-1
6.804E-1
 3 200
26 M6781 Genes down-regulated in lymph node B lymphocytes: influenza infected versus interferon beta stimulation. MSigDB C7: Immunologic Signatures (v5.1) 3.866E-4 2.062E-2
1.660E-1
6.804E-1
 3 200
27 GSE43863 LY6C INT CXCR5POS VS LY6C LOW CXCR5NEG EFFECTOR CD4 TCELL UP Genes up-regulated in CD4 [GeneID=920] SMARTA effector T cells during acute infection of LCMV: Ly6c int CXCR5+ [GeneID=643] versus Ly6c low CXCR5- [GeneID=643]. MSigDB C7: Immunologic Signatures (v5.1) 3.866E-4 2.062E-2
1.660E-1
6.804E-1
 3 200
28 M3713 Genes up-regulated in comparison of control dendritic cells (DC) at 4 h versus those stimulated with poly(I:C) (TLR3 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v5.1) 3.866E-4 2.062E-2
1.660E-1
6.804E-1
 3 200
29 M3699 Genes up-regulated in comparison of control dendritic cells (DC) at 8 h versus those stimulated with LPS (TLR4 agonist) at 8 h. MSigDB C7: Immunologic Signatures (v5.1) 3.866E-4 2.062E-2
1.660E-1
6.804E-1
 3 200
30 M6243 Genes down-regulated in thymocytes: double negative versus CD4 [GeneID=920] single positive. MSigDB C7: Immunologic Signatures (v5.1) 3.866E-4 2.062E-2
1.660E-1
6.804E-1
 3 200
31 M4531 Genes down-regulated in comparison of unstimulated NK cells versus those stimulated with IL2 [GeneID=3558] at 16 h. MSigDB C7: Immunologic Signatures (v5.1) 3.866E-4 2.062E-2
1.660E-1
6.804E-1
 3 200
32 M3979 Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 24 h. MSigDB C7: Immunologic Signatures (v5.1) 3.866E-4 2.062E-2
1.660E-1
6.804E-1
 3 200
33 M4533 Genes down-regulated in comparison of unstimulated NK cells versus those stimulated with IL2 [GeneID=3600] at 16 h. MSigDB C7: Immunologic Signatures (v5.1) 3.866E-4 2.062E-2
1.660E-1
6.804E-1
 3 200
34 M1647 Genes up-regulated in liver from mice with liver specific knockout of POR [GeneID=5447]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.048E-4 2.095E-2
1.687E-1
7.124E-1
 2 41
35 M13422 Genes up-regulated in basal mammary epithelial cells compared to the luminal ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.025E-4 3.435E-2
2.765E-1
1.000E0
 2 54
36 M1603 Genes up-regulated in HeLa cells (cervical carcinoma) at 30 min after stimulation with TNF [GeneID=7124]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.025E-4 3.435E-2
2.765E-1
1.000E0
 2 54
37 M1796 The glioblastoma multiforme (GBM) plasticity signature: genes up-regulated in neural stem cells (NSC) with double knockout of TP53 and PTEN [GeneID=7157;5728] vs those with knockout of TP53 alone. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.406E-4 3.523E-2
2.836E-1
1.000E0
 3 250
38 M12029 Genes selected in supervised analyses to discriminate cells expressing activated HRAS [GeneID=3265] oncogene from control cells expressing GFP. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.390E-4 3.886E-2
3.128E-1
1.000E0
 3 261
39 M11640 Genes down-regulated in hepatocellular carcinoma (HCC) induced by ciprofibrate [PubChem=2763]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.048E-3 4.728E-2
3.806E-1
1.000E0
 2 66
40 M1145 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 1. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.112E-3 4.891E-2
3.938E-1
1.000E0
 2 68
Show 35 more annotations

14: Coexpression Atlas [Display Chart] 1227 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 OPC Top 500 All OPC Top 500 All Brain Map - Barres 1.085E-6 1.332E-3 1.024E-2 1.332E-3 6 494
2 54Dn SubClass 54Dn 4 Top 500 All 54Dn SubClass 54Dn 4 Top 500 All Brain Map - Allen iN 2.337E-5 9.652E-3
7.423E-2
 2.867E-2 5 487
3 54SK Top 500 All 54SK Top 500 All Brain Map - Allen iN 2.360E-5 9.652E-3
7.423E-2
 2.896E-2 5 488
4 54SK SubClass 54SK 1 Top 500 Cluster 3 54SK SubClass 54SK 1 Top 500 Cluster 3 Brain Map - Allen iN 3.342E-5 1.025E-2
7.884E-2
 4.101E-2 3 84
5 26Dn Top 500 Cluster 0 26Dn Top 500 Cluster 0 Brain Map - Allen iN 4.984E-5 1.223E-2
9.405E-2
6.115E-2
 3 96
6 54Dn SubClass 54Dn 4 Top 500 Cluster 2 54Dn SubClass 54Dn 4 Top 500 Cluster 2 Brain Map - Allen iN 8.759E-5 1.698E-2
1.306E-1
1.075E-1
 3 116
7 gudmap developingLowerUrinaryTract e14.5 urogenital sinus 1000 k1 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-5517 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 9.687E-5 1.698E-2
1.306E-1
1.189E-1
 3 120
8 astrocytes Top 500 Cluster 3 astrocytes Top 500 Cluster 3 Brain Map - Barres 3.018E-4 3.440E-2
2.645E-1
3.702E-1
 2 34
9 gudmap kidney e15.5 SmlBldVes Tie2 200 kidney e15.5 SmlBldVes Tie2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.154E-4 3.440E-2
2.645E-1
3.870E-1
 3 179
10 fetal quiescent Top 500 Cluster 1 fetal quiescent Top 500 Cluster 1 Brain Map - Barres 3.199E-4 3.440E-2
2.645E-1
3.925E-1
 2 35
11 PCBC ratio ECTO amniotic fluid MSC vs ECTO blastocyst cfr-2X-p05 ECTO amniotic fluid MSC vs ECTO blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 3.642E-4 3.440E-2
2.645E-1
4.469E-1
 3 188
12 gudmap kidney e15.5 SmlBldVes Tie2 k4 200 kidney e15.5 SmlBldVes Tie2 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.977E-4 3.440E-2
2.645E-1
4.880E-1
 2 39
13 54SK Top 500 Cluster 3 54SK Top 500 Cluster 3 Brain Map - Allen iN 3.977E-4 3.440E-2
2.645E-1
4.880E-1
 2 39
14 fetal quiescent Top 500 All fetal quiescent Top 500 All Brain Map - Barres 4.251E-4 3.440E-2
2.645E-1
5.215E-1
 4 489
15 26Dn Top 500 All 26Dn Top 500 All Brain Map - Allen iN 4.485E-4 3.440E-2
2.645E-1
5.504E-1
 4 496
16 astrocytes Top 500 All astrocytes Top 500 All Brain Map - Barres 4.485E-4 3.440E-2
2.645E-1
5.504E-1
 4 496
17 gudmap kidney e15.5 SmlBldVes Tie2 k4 100 kidney e15.5 SmlBldVes Tie2 k-means-cluster#4 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 7.628E-4 4.926E-2
3.788E-1
9.360E-1
 1 1
18 gudmap dev gonad e11.5 F ReproVasc Flk k1 100 dev gonad e11.5 F ReproVasc Flk k-means-cluster#1 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 7.628E-4 4.926E-2
3.788E-1
9.360E-1
 1 1
19 gudmap dev gonad e11.5 F ReproVasc Flk k2 200 dev gonad e11.5 F ReproVasc Flk k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 7.628E-4 4.926E-2
3.788E-1
9.360E-1
 1 1
Show 14 more annotations

15: Computational [Display Chart] 126 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 6.054E-6 7.628E-4 4.132E-3 7.628E-4 6 351
2 GNF2 PA2G4 Neighborhood of PA2G4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.539E-4 9.694E-3
5.252E-2
 1.939E-2 3 73

16: MicroRNA [Display Chart] 430 annotations before applied cutoff / 19844 genes in category

No results to display

17: Drug [Display Chart] 4795 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MESH:D011471/D015032-M Prostatic Neoplasms affected by Zinc CTD Marker 6.349E-6 1.176E-2
1.065E-1
 3.044E-2 3 51
2 MESH:D011471/D015032-T Prostatic Neoplasms affected by Zinc CTD Therapeutic 6.349E-6 1.176E-2
1.065E-1
 3.044E-2 3 51
3 CID000011198 ethylamine hydrochloride Stitch 7.360E-6 1.176E-2
1.065E-1
 3.529E-2 2 6
4 5492 UP Loracarbef [121961-22-6]; Up 200; 10.8uM; MCF7; HT HG-U133A Broad Institute CMAP 1.046E-5 1.254E-2
1.135E-1
5.015E-2
 4 198
5 CID009549278 K00051 Stitch 1.727E-5 1.410E-2
1.276E-1
8.282E-2
 3 71
6 CID009547195 (3S,5aR,5bS,9S,11aS,11bR,13bS)-3-isopropenyl-5a,5b,8,8,11a,11b,13b-heptamethyl-2,3,3a,4,5,6,7,7a,9,10,11,12,13,13a-tetradecahydro-1H-cyclopenta[a]chrysen-9-ol Stitch 1.764E-5 1.410E-2
1.276E-1
8.459E-2
 2 9
7 CID000031261 acetylacetone Stitch 9.268E-5 2.591E-2
2.345E-1
4.444E-1
 2 20
8 CID000062816 colestipol Stitch 1.126E-4 2.591E-2
2.345E-1
5.398E-1
 2 22
9 CID000123195 diimine Stitch 1.233E-4 2.591E-2
2.345E-1
5.910E-1
 2 23
10 CID000069310 tricaprin Stitch 1.233E-4 2.591E-2
2.345E-1
5.910E-1
 2 23
11 D009966 Orphenadrine CTD 1.330E-4 2.591E-2
2.345E-1
6.377E-1
 4 380
12 CID000009035 KC-33 Stitch 1.344E-4 2.591E-2
2.345E-1
6.444E-1
 2 24
13 C096064 actein CTD 1.973E-4 2.591E-2
2.345E-1
9.460E-1
 2 29
14 CID000101179 AC1L2Q9X Stitch 1.973E-4 2.591E-2
2.345E-1
9.460E-1
 2 29
15 6047 UP Helveticoside [630-64-8]; Up 200; 7.4uM; MCF7; HT HG-U133A Broad Institute CMAP 2.247E-4 2.591E-2
2.345E-1
1.000E0
 3 168
16 C495817 CC-8490 CTD 2.258E-4 2.591E-2
2.345E-1
1.000E0
 2 31
17 CID003086323 Muracein C Stitch 2.407E-4 2.591E-2
2.345E-1
1.000E0
 2 32
18 CID000024405 isopentenyladenosine Stitch 2.720E-4 2.591E-2
2.345E-1
1.000E0
 2 34
19 CID012725854 sodium; lithium Stitch 3.052E-4 2.591E-2
2.345E-1
1.000E0
 2 36
20 CID011840956 I CR Stitch 3.052E-4 2.591E-2
2.345E-1
1.000E0
 2 36
21 2967 DN Lansoprazole [103577-45-3]; Down 200; 10.8uM; HL60; HT HG-U133A Broad Institute CMAP 3.177E-4 2.591E-2
2.345E-1
1.000E0
 3 189
22 D012839 Simazine CTD 3.403E-4 2.591E-2
2.345E-1
1.000E0
 2 38
23 3217 UP Phenylpropanolamine hydrochloride [154-41-6]; Up 200; 21.4uM; MCF7; HT HG-U133A Broad Institute CMAP 3.481E-4 2.591E-2
2.345E-1
1.000E0
 3 195
24 3025 UP Acetaminophen [103-90-2]; Up 200; 26.4uM; HL60; HT HG-U133A Broad Institute CMAP 3.534E-4 2.591E-2
2.345E-1
1.000E0
 3 196
25 3064 UP Xamoterol hemifumarate [73210-73-8]; Up 200; 5uM; HL60; HT HG-U133A Broad Institute CMAP 3.534E-4 2.591E-2
2.345E-1
1.000E0
 3 196
26 7378 UP Flurandrenolide [1524-88-5]; Up 200; 9.2uM; PC3; HT HG-U133A Broad Institute CMAP 3.534E-4 2.591E-2
2.345E-1
1.000E0
 3 196
27 CID000010541 trimethyl phosphate Stitch 3.586E-4 2.591E-2
2.345E-1
1.000E0
 2 39
28 CID005326858 4-amino 5-hydroxy pentanoic acid Stitch 3.586E-4 2.591E-2
2.345E-1
1.000E0
 2 39
29 4702 UP Flurandrenolide [1524-88-5]; Up 200; 9.2uM; MCF7; HT HG-U133A Broad Institute CMAP 3.587E-4 2.591E-2
2.345E-1
1.000E0
 3 197
30 4653 UP Phthalylsulfathiazole [85-73-4]; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 3.587E-4 2.591E-2
2.345E-1
1.000E0
 3 197
31 5767 UP Retinoic acid [302-79-4]; Up 200; 13.4uM; PC3; HT HG-U133A Broad Institute CMAP 3.587E-4 2.591E-2
2.345E-1
1.000E0
 3 197
32 3793 UP Quinethazone [73-49-4]; Up 200; 13.8uM; PC3; HT HG-U133A Broad Institute CMAP 3.587E-4 2.591E-2
2.345E-1
1.000E0
 3 197
33 5059 UP Flufenamic acid [530-78-9]; Up 200; 14.2uM; PC3; HT HG-U133A Broad Institute CMAP 3.641E-4 2.591E-2
2.345E-1
1.000E0
 3 198
34 6648 UP Clomiphene citrate (Z,E) [50-41-9]; Up 200; 6.6uM; PC3; HT HG-U133A Broad Institute CMAP 3.641E-4 2.591E-2
2.345E-1
1.000E0
 3 198
35 2498 UP Vancomycin hydrochloride [1404-93-9]; Up 200; 2.6uM; HL60; HT HG-U133A Broad Institute CMAP 3.695E-4 2.591E-2
2.345E-1
1.000E0
 3 199
36 6751 UP Ceforanide [60925-61-3]; Up 200; 7.6uM; PC3; HT HG-U133A Broad Institute CMAP 3.695E-4 2.591E-2
2.345E-1
1.000E0
 3 199
37 6735 UP Neostigmine bromide [114-80-7]; Up 200; 13.2uM; PC3; HT HG-U133A Broad Institute CMAP 3.695E-4 2.591E-2
2.345E-1
1.000E0
 3 199
38 2285 UP Nifenazone [2139-47-1]; Up 200; 13uM; MCF7; HT HG-U133A Broad Institute CMAP 3.695E-4 2.591E-2
2.345E-1
1.000E0
 3 199
39 4592 UP Bacampicillin hydrochloride [37661-08-8]; Up 200; 8uM; PC3; HT HG-U133A Broad Institute CMAP 3.695E-4 2.591E-2
2.345E-1
1.000E0
 3 199
40 6136 UP Trifluridine [70-00-8]; Up 200; 13.6uM; HL60; HT HG-U133A Broad Institute CMAP 3.695E-4 2.591E-2
2.345E-1
1.000E0
 3 199
41 4645 UP Naloxone hydrochloride [357-08-4]; Up 200; 11uM; PC3; HT HG-U133A Broad Institute CMAP 3.695E-4 2.591E-2
2.345E-1
1.000E0
 3 199
42 CID000005312 succinylacetone Stitch 4.568E-4 2.591E-2
2.345E-1
1.000E0
 2 44
43 CID000015419 M977 Stitch 5.437E-4 2.591E-2
2.345E-1
1.000E0
 2 48
44 CID000155435 EM-652 Stitch 5.666E-4 2.591E-2
2.345E-1
1.000E0
 2 49
45 C008922 piperine CTD 6.138E-4 2.591E-2
2.345E-1
1.000E0
 2 51
46 CID000006323 methyl bromide Stitch 6.138E-4 2.591E-2
2.345E-1
1.000E0
 2 51
47 C002994 ethylene dimethanesulfonate CTD 6.381E-4 2.591E-2
2.345E-1
1.000E0
 2 52
48 D002101 Cacodylic Acid CTD 7.101E-4 2.591E-2
2.345E-1
1.000E0
 3 249
49 CID014717865 CTK0E2505 Stitch 7.240E-4 2.591E-2
2.345E-1
1.000E0
 1 1
50 CID000082222 Aluminum iodide Stitch 7.240E-4 2.591E-2
2.345E-1
1.000E0
 1 1
Show 45 more annotations

18: Disease [Display Chart] 394 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C1336708 Testicular Germ Cell Tumor DisGeNET Curated 9.494E-5 1.687E-2
1.106E-1
 3.741E-2 3 92
2 umls:C0239981 Hypoalbuminemia DisGeNET Curated 1.558E-4 1.687E-2
1.106E-1
6.139E-2
 2 19
3 umls:C0079748 Precursor cell lymphoblastic lymphoma DisGeNET BeFree 8.497E-4 1.687E-2
1.106E-1
3.348E-1
 2 44
4 umls:C0432408 Trisomy 12 DisGeNET BeFree 9.692E-4 1.687E-2
1.106E-1
3.819E-1
 2 47
5 238600 HYPERLIPOPROTEINEMIA, TYPE I OMIM 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
6 cv:C1848138 X inactivation, familial skewed, 1 Clinical Variations 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
7 umls:C2239290 Hodgkin lymphoma, nodular lymphocyte predominance DisGeNET BeFree 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
8 20090204:Muglia Major depressive disorder GWAS 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
9 umls:C3808986 HYPOGONADOTROPIC HYPOGONADISM 21 WITH OR WITHOUT ANOSMIA DisGeNET Curated 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
10 cv:C1863095 Alpha-2-macroglobulin deficiency Clinical Variations 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
11 umls:C1848138 X INACTIVATION, FAMILIAL SKEWED, 1 (disorder) DisGeNET Curated 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
12 umls:C1261969 Type I hyperlipidaemia DisGeNET BeFree 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
13 umls:C3279661 alpha-2-Macroglobulin Deficiency DisGeNET BeFree 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
14 umls:C0241784 alphalipoproteinemia DisGeNET BeFree 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
15 cv:C0020474 Hyperlipidemia, familial combined Clinical Variations 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
16 cv:CN170857 Hypogonadotropic hypogonadism 21 with or without anosmia Clinical Variations 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
17 umls:C0206744 T-Lymphocytopenia, Idiopathic CD4-Positive DisGeNET BeFree 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
18 umls:C0431603 Ectopic liver DisGeNET BeFree 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
19 cv:C0023817 Hyperlipoproteinemia, type I Clinical Variations 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
20 umls:C4014742 MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 3 DisGeNET Curated 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
21 umls:C0342889 Secondary hypertriglyceridemia DisGeNET BeFree 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
22 umls:C0268197 Familial lipoprotein deficiency DisGeNET BeFree 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
23 cv:CN207694 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 Clinical Variations 9.907E-4 1.687E-2
1.106E-1
3.903E-1
 1 1
24 umls:C0036631 Seminoma DisGeNET Curated 1.028E-3 1.687E-2
1.106E-1
4.048E-1
 3 207
25 umls:C0205851 Germ cell tumor DisGeNET BeFree 1.324E-3 2.086E-2
1.367E-1
5.215E-1
 3 226
26 umls:C0278836 Stage III Prostate Carcinoma DisGeNET BeFree 1.981E-3 2.109E-2
1.382E-1
7.803E-1
 1 2
27 umls:C1720779 Apolipoprotein C-II Deficiency (disorder) DisGeNET Curated 1.981E-3 2.109E-2
1.382E-1
7.803E-1
 1 2
28 umls:C1332632 Breast Liposarcoma DisGeNET BeFree 1.981E-3 2.109E-2
1.382E-1
7.803E-1
 1 2
29 umls:C0221252 Eruptive xanthoma DisGeNET BeFree 1.981E-3 2.109E-2
1.382E-1
7.803E-1
 1 2
30 cv:C1838332 Helicobacter pylori infection, susceptibility to Clinical Variations 1.981E-3 2.109E-2
1.382E-1
7.803E-1
 1 2
31 144250 HYPERLIPIDEMIA, FAMILIAL COMBINED; FCHL OMIM 1.981E-3 2.109E-2
1.382E-1
7.803E-1
 1 2
32 umls:C0151826 Retrosternal pain DisGeNET BeFree 1.981E-3 2.109E-2
1.382E-1
7.803E-1
 1 2
33 umls:C1279645 Xanthoma diabeticorum (disorder) DisGeNET BeFree 1.981E-3 2.109E-2
1.382E-1
7.803E-1
 1 2
34 umls:C1855498 Lipase deficiency combined DisGeNET Curated 1.981E-3 2.109E-2
1.382E-1
7.803E-1
 1 2
35 umls:C0238096 Embolism, Paradoxical DisGeNET BeFree 1.981E-3 2.109E-2
1.382E-1
7.803E-1
 1 2
36 umls:C1274228 Chylomicronemia syndrome DisGeNET BeFree 1.981E-3 2.109E-2
1.382E-1
7.803E-1
 1 2
37 600263 HELICOBACTER PYLORI INFECTION, SUSCEPTIBILITY TO OMIM 1.981E-3 2.109E-2
1.382E-1
7.803E-1
 1 2
38 umls:C1333849 Grade 3b Follicular Lymphoma DisGeNET BeFree 2.969E-3 2.786E-2
1.826E-1
1.000E0
 1 3
39 umls:C1849409 Knobloch syndrome DisGeNET Curated 2.969E-3 2.786E-2
1.826E-1
1.000E0
 1 3
40 umls:C2585575 Recurrent abdominal pain DisGeNET BeFree 2.969E-3 2.786E-2
1.826E-1
1.000E0
 1 3
41 20090213:Saxena Triglycerides GWAS 2.969E-3 2.786E-2
1.826E-1
1.000E0
 1 3
42 umls:C2698750 Pediatric Follicular Lymphoma DisGeNET BeFree 2.969E-3 2.786E-2
1.826E-1
1.000E0
 1 3
43 umls:C0039590 Testicular Neoplasms DisGeNET Curated 3.204E-3 2.887E-2
1.893E-1
1.000E0
 2 86
44 umls:C2004493 Leukemia, B-Cell DisGeNET BeFree 3.657E-3 2.887E-2
1.893E-1
1.000E0
 2 92
45 umls:C0264511 Lymphoid interstitial pneumonia DisGeNET BeFree 3.957E-3 2.887E-2
1.893E-1
1.000E0
 1 4
46 umls:C0280248 stage, chronic lymphocytic leukemia DisGeNET BeFree 3.957E-3 2.887E-2
1.893E-1
1.000E0
 1 4
47 umls:C0242338 HTLV Infections DisGeNET BeFree 3.957E-3 2.887E-2
1.893E-1
1.000E0
 1 4
48 20081125:Chambers Waist circumference and related phenotypes GWAS 3.957E-3 2.887E-2
1.893E-1
1.000E0
 1 4
49 umls:C3697776 Proliferative verrucous oral leukoplakia DisGeNET BeFree 3.957E-3 2.887E-2
1.893E-1
1.000E0
 1 4
50 umls:C0268553 Hyperlysinemias DisGeNET Curated 3.957E-3 2.887E-2
1.893E-1
1.000E0
 1 4
Show 45 more annotations