Toppgene analysis for aggregated_1964_log, IC18, positive side

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1: GO: Molecular Function [Display Chart] 687 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005539 glycosaminoglycan binding 7.895E-10 5.424E-7 3.856E-6 5.424E-7 16 219
2 GO:0005201 extracellular matrix structural constituent 6.025E-9 2.070E-6 1.472E-5 4.139E-6 10 78
3 GO:1901681 sulfur compound binding 4.203E-7 9.626E-5 6.844E-4 2.888E-4 14 260
4 GO:0008201 heparin binding 1.068E-6 1.835E-4 1.304E-3 7.338E-4 11 167
5 GO:0005178 integrin binding 4.123E-6 5.664E-4 4.028E-3 2.832E-3 9 122
6 GO:0038024 cargo receptor activity 7.378E-6 7.310E-4 5.198E-3 5.069E-3 7 71
7 GO:0005044 scavenger receptor activity 7.449E-6 7.310E-4 5.198E-3 5.117E-3 6 47
8 GO:0050839 cell adhesion molecule binding 9.354E-6 8.033E-4 5.711E-3 6.426E-3 11 209
9 GO:0019838 growth factor binding 1.420E-5 1.084E-3 7.707E-3 9.756E-3 9 142
10 GO:0043394 proteoglycan binding 2.526E-5 1.736E-3 1.234E-2 1.736E-2 5 35
11 GO:0001948 glycoprotein binding 2.985E-5 1.864E-3 1.325E-2 2.051E-2 8 120
12 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 3.762E-5 2.154E-3 1.531E-2 2.584E-2 6 62
13 GO:0008083 growth factor activity 4.889E-5 2.584E-3 1.837E-2 3.359E-2 9 166
14 GO:0016303 1-phosphatidylinositol-3-kinase activity 7.017E-5 3.443E-3 2.448E-2 4.820E-2 5 43
15 GO:0052813 phosphatidylinositol bisphosphate kinase activity 8.795E-5 3.776E-3 2.685E-2
6.042E-2
 6 72
16 GO:0005518 collagen binding 8.795E-5 3.776E-3 2.685E-2
6.042E-2
 6 72
17 GO:0008237 metallopeptidase activity 1.273E-4 4.629E-3 3.291E-2
8.742E-2
 9 188
18 GO:0046332 SMAD binding 1.280E-4 4.629E-3 3.291E-2
8.794E-2
 6 77
19 GO:0035004 phosphatidylinositol 3-kinase activity 1.280E-4 4.629E-3 3.291E-2
8.794E-2
 6 77
20 GO:0005104 fibroblast growth factor receptor binding 1.705E-4 5.856E-3 4.164E-2
1.171E-1
 4 28
21 GO:0048407 platelet-derived growth factor binding 2.084E-4 6.817E-3 4.847E-2
1.432E-1
 3 12
22 GO:0050840 extracellular matrix binding 2.723E-4 8.503E-3
6.046E-2
1.871E-1
 5 57
23 GO:0052742 phosphatidylinositol kinase activity 2.956E-4 8.650E-3
6.150E-2
2.030E-1
 5 58
24 GO:0035373 chondroitin sulfate proteoglycan binding 3.022E-4 8.650E-3
6.150E-2
2.076E-1
 2 3
25 GO:0070851 growth factor receptor binding 6.305E-4 1.733E-2
1.232E-1
4.332E-1
 7 143
26 GO:0008823 cupric reductase activity 9.939E-4 2.316E-2
1.647E-1
6.828E-1
 2 5
27 GO:0004528 phosphodiesterase I activity 9.939E-4 2.316E-2
1.647E-1
6.828E-1
 2 5
28 GO:0038085 vascular endothelial growth factor binding 9.939E-4 2.316E-2
1.647E-1
6.828E-1
 2 5
29 GO:0052851 ferric-chelate reductase (NADPH) activity 9.939E-4 2.316E-2
1.647E-1
6.828E-1
 2 5
30 GO:0004222 metalloendopeptidase activity 1.011E-3 2.316E-2
1.647E-1
6.948E-1
 6 113
31 GO:0005085 guanyl-nucleotide exchange factor activity 1.131E-3 2.507E-2
1.783E-1
7.773E-1
 10 306
32 GO:0008194 UDP-glycosyltransferase activity 1.310E-3 2.812E-2
1.999E-1
8.999E-1
 7 162
33 GO:0016758 transferase activity, transferring hexosyl groups 1.351E-3 2.812E-2
1.999E-1
9.279E-1
 8 210
34 GO:0045545 syndecan binding 1.481E-3 2.992E-2
2.128E-1
1.000E0
 2 6
35 GO:0043395 heparan sulfate proteoglycan binding 1.546E-3 3.034E-2
2.157E-1
1.000E0
 3 23
36 GO:0005021 vascular endothelial growth factor-activated receptor activity 2.060E-3 3.930E-2
2.795E-1
1.000E0
 2 7
37 GO:0019199 transmembrane receptor protein kinase activity 2.295E-3 4.262E-2
3.030E-1
1.000E0
 5 91
38 GO:0004175 endopeptidase activity 2.413E-3 4.360E-2
3.100E-1
1.000E0
 12 457
39 GO:0005088 Ras guanyl-nucleotide exchange factor activity 2.519E-3 4.360E-2
3.100E-1
1.000E0
 8 232
40 GO:0004713 protein tyrosine kinase activity 2.538E-3 4.360E-2
3.100E-1
1.000E0
 7 182
41 GO:0005520 insulin-like growth factor binding 2.756E-3 4.617E-2
3.283E-1
1.000E0
 3 28
42 GO:0042056 chemoattractant activity 3.051E-3 4.990E-2
3.548E-1
1.000E0
 3 29
Show 37 more annotations

2: GO: Biological Process [Display Chart] 3495 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030198 extracellular matrix organization 3.963E-20 7.523E-17 6.573E-16 1.385E-16 31 354
2 GO:0043062 extracellular structure organization 4.305E-20 7.523E-17 6.573E-16 1.505E-16 31 355
3 GO:0001503 ossification 3.394E-11 3.954E-8 3.455E-7 1.186E-7 23 406
4 GO:0001525 angiogenesis 4.955E-10 4.330E-7 3.783E-6 1.732E-6 23 465
5 GO:0045765 regulation of angiogenesis 3.622E-9 2.532E-6 2.212E-5 1.266E-5 16 239
6 GO:0048738 cardiac muscle tissue development 6.918E-9 4.030E-6 3.521E-5 2.418E-5 15 216
7 GO:1901342 regulation of vasculature development 1.495E-8 7.464E-6 6.521E-5 5.225E-5 16 264
8 GO:0030574 collagen catabolic process 2.707E-8 1.183E-5 1.033E-4 9.461E-5 9 67
9 GO:0001655 urogenital system development 3.306E-8 1.284E-5 1.121E-4 1.155E-4 18 358
10 GO:0044243 multicellular organismal catabolic process 6.577E-8 2.023E-5 1.767E-4 2.299E-4 9 74
11 GO:0090287 regulation of cellular response to growth factor stimulus 6.694E-8 2.023E-5 1.767E-4 2.340E-4 15 256
12 GO:0060537 muscle tissue development 6.944E-8 2.023E-5 1.767E-4 2.427E-4 19 419
13 GO:0042476 odontogenesis 1.016E-7 2.731E-5 2.386E-4 3.551E-4 11 130
14 GO:0072001 renal system development 1.450E-7 3.620E-5 3.163E-4 5.068E-4 16 311
15 GO:0010634 positive regulation of epithelial cell migration 1.999E-7 4.657E-5 4.068E-4 6.985E-4 10 110
16 GO:0097306 cellular response to alcohol 2.331E-7 4.672E-5 4.082E-4 8.146E-4 11 141
17 GO:0007517 muscle organ development 2.522E-7 4.672E-5 4.082E-4 8.816E-4 18 410
18 GO:0031589 cell-substrate adhesion 2.526E-7 4.672E-5 4.082E-4 8.827E-4 16 324
19 GO:0007584 response to nutrient 2.606E-7 4.672E-5 4.082E-4 9.108E-4 13 209
20 GO:0010632 regulation of epithelial cell migration 2.674E-7 4.672E-5 4.082E-4 9.345E-4 12 175
21 GO:0001822 kidney development 3.842E-7 6.395E-5 5.587E-4 1.343E-3 15 293
22 GO:0022617 extracellular matrix disassembly 4.410E-7 7.007E-5 6.121E-4 1.541E-3 9 92
23 GO:0032963 collagen metabolic process 5.280E-7 8.024E-5 7.010E-4 1.845E-3 10 122
24 GO:0044259 multicellular organismal macromolecule metabolic process 7.664E-7 1.116E-4 9.751E-4 2.679E-3 10 127
25 GO:0014706 striated muscle tissue development 8.948E-7 1.251E-4 1.093E-3 3.127E-3 17 401
26 GO:0010631 epithelial cell migration 9.901E-7 1.296E-4 1.132E-3 3.460E-3 13 235
27 GO:0051216 cartilage development 1.003E-6 1.296E-4 1.132E-3 3.506E-3 12 198
28 GO:0009612 response to mechanical stimulus 1.039E-6 1.296E-4 1.132E-3 3.630E-3 13 236
29 GO:0090132 epithelium migration 1.142E-6 1.376E-4 1.202E-3 3.990E-3 13 238
30 GO:0090130 tissue migration 1.508E-6 1.757E-4 1.535E-3 5.271E-3 13 244
31 GO:0001101 response to acid chemical 1.574E-6 1.775E-4 1.551E-3 5.502E-3 16 372
32 GO:0042698 ovulation cycle 1.755E-6 1.917E-4 1.675E-3 6.135E-3 10 139
33 GO:0071305 cellular response to vitamin D 1.935E-6 2.049E-4 1.790E-3 6.763E-3 5 21
34 GO:0045785 positive regulation of cell adhesion 2.107E-6 2.166E-4 1.892E-3 7.364E-3 17 427
35 GO:0044236 multicellular organism metabolic process 2.576E-6 2.572E-4 2.247E-3 9.002E-3 10 145
36 GO:0033280 response to vitamin D 2.677E-6 2.599E-4 2.271E-3 9.358E-3 6 39
37 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 3.064E-6 2.894E-4 2.528E-3 1.071E-2 15 346
38 GO:0050673 epithelial cell proliferation 3.302E-6 3.037E-4 2.653E-3 1.154E-2 16 394
39 GO:0030335 positive regulation of cell migration 3.778E-6 3.385E-4 2.958E-3 1.320E-2 17 446
40 GO:0061448 connective tissue development 4.245E-6 3.709E-4 3.240E-3 1.484E-2 13 268
41 GO:0055024 regulation of cardiac muscle tissue development 5.057E-6 4.311E-4 3.766E-3 1.767E-2 7 66
42 GO:2000147 positive regulation of cell motility 5.529E-6 4.512E-4 3.942E-3 1.932E-2 17 459
43 GO:0030199 collagen fibril organization 5.551E-6 4.512E-4 3.942E-3 1.940E-2 6 44
44 GO:0031670 cellular response to nutrient 7.241E-6 5.752E-4 5.025E-3 2.531E-2 6 46
45 GO:0051272 positive regulation of cellular component movement 7.759E-6 6.026E-4 5.265E-3 2.712E-2 17 471
46 GO:0060038 cardiac muscle cell proliferation 9.327E-6 6.994E-4 6.110E-3 3.260E-2 6 48
47 GO:0040017 positive regulation of locomotion 9.406E-6 6.994E-4 6.110E-3 3.287E-2 17 478
48 GO:0045766 positive regulation of angiogenesis 9.625E-6 7.008E-4 6.123E-3 3.364E-2 9 133
49 GO:0030278 regulation of ossification 1.007E-5 7.185E-4 6.277E-3 3.521E-2 11 207
50 GO:2000987 positive regulation of behavioral fear response 1.052E-5 7.208E-4 6.297E-3 3.676E-2 3 5
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 292 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031012 extracellular matrix 2.316E-20 6.763E-18 4.231E-17 6.763E-18 34 444
2 GO:0005578 proteinaceous extracellular matrix 1.920E-19 2.803E-17 1.754E-16 5.606E-17 31 379
3 GO:0044420 extracellular matrix component 5.916E-15 5.759E-13 3.602E-12 1.728E-12 18 143
4 GO:0005581 collagen trimer 2.031E-8 1.483E-6 9.277E-6 5.932E-6 10 88
5 GO:0098644 complex of collagen trimers 8.691E-8 5.076E-6 3.175E-5 2.538E-5 6 23
6 GO:0005604 basement membrane 1.897E-7 9.232E-6 5.775E-5 5.539E-5 10 111
7 GO:0005583 fibrillar collagen trimer 4.722E-6 1.724E-4 1.078E-3 1.379E-3 4 12
8 GO:0098643 banded collagen fibril 4.722E-6 1.724E-4 1.078E-3 1.379E-3 4 12
9 GO:0009897 external side of plasma membrane 8.132E-5 2.638E-3 1.650E-2 2.375E-2 12 311
10 GO:0005788 endoplasmic reticulum lumen 2.667E-4 6.819E-3 4.266E-2
7.787E-2
 9 207
11 GO:0043202 lysosomal lumen 2.705E-4 6.819E-3 4.266E-2
7.899E-2
 6 88
12 GO:0005589 collagen type VI trimer 3.036E-4 6.819E-3 4.266E-2
8.864E-2
 2 3
13 GO:0098647 collagen beaded filament 3.036E-4 6.819E-3 4.266E-2
8.864E-2
 2 3
14 GO:0005912 adherens junction 4.286E-4 8.940E-3
5.592E-2
1.252E-1
 14 484
15 GO:0005913 cell-cell adherens junction 6.267E-4 1.220E-2
7.631E-2
1.830E-1
 5 68
16 GO:0005925 focal adhesion 6.882E-4 1.256E-2
7.857E-2
2.010E-1
 12 393
17 GO:0005924 cell-substrate adherens junction 7.684E-4 1.320E-2
8.256E-2
2.244E-1
 12 398
18 GO:0030055 cell-substrate junction 8.562E-4 1.389E-2
8.689E-2
2.500E-1
 12 403
19 GO:0005775 vacuolar lumen 1.173E-3 1.803E-2
1.128E-1
3.426E-1
 6 116
20 GO:0098857 membrane microdomain 2.666E-3 3.707E-2
2.319E-1
7.784E-1
 10 343
21 GO:0045121 membrane raft 2.666E-3 3.707E-2
2.319E-1
7.784E-1
 10 343
22 GO:0005796 Golgi lumen 2.927E-3 3.717E-2
2.325E-1
8.548E-1
 5 96
23 GO:0005901 caveola 2.927E-3 3.717E-2
2.325E-1
8.548E-1
 5 96
24 GO:0005911 cell-cell junction 3.770E-3 4.586E-2
2.869E-1
1.000E0
 11 420
Show 19 more annotations

4: Human Phenotype [Display Chart] 779 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0005622 Broad long bones {has synonym type="layperson"} 2.994E-5 2.301E-2
1.665E-1
 2.332E-2 3 5
2 HP:0000978 Bruising susceptibility {has synonym type="layperson"} 7.535E-5 2.301E-2
1.665E-1
5.870E-2
 7 72
3 HP:0011001 Increased bone mineral density {has synonym type="layperson"} 8.861E-5 2.301E-2
1.665E-1
6.902E-2
 4 17
4 HP:0006480 Premature loss of teeth 1.411E-4 2.530E-2
1.831E-1
1.099E-1
 4 19
5 HP:0000696 Delayed eruption of permanent teeth {has synonym type="layperson"} 1.624E-4 2.530E-2
1.831E-1
1.265E-1
 3 8
6 HP:0001450 Y-linked inheritance 2.576E-4 3.220E-2
2.330E-1
2.007E-1
 4 22
7 HP:0002688 Absent frontal sinuses 3.407E-4 3.220E-2
2.330E-1
2.654E-1
 3 10
8 HP:0000765 Abnormality of the thorax 3.661E-4 3.220E-2
2.330E-1
2.852E-1
 4 24
9 HP:0001634 Mitral valve prolapse 3.720E-4 3.220E-2
2.330E-1
2.898E-1
 5 43
10 HP:0000592 Blue sclerae 4.615E-4 3.595E-2
2.601E-1
3.595E-1
 5 45
11 HP:0006384 Club-shaped distal femur 6.357E-4 3.810E-2
2.757E-1
4.952E-1
 2 3
12 HP:0004407 Bony paranasal bossing 6.357E-4 3.810E-2
2.757E-1
4.952E-1
 2 3
13 HP:0004474 Persistent open anterior fontanelle 6.357E-4 3.810E-2
2.757E-1
4.952E-1
 2 3
14 HP:0003016 Metaphyseal widening 7.742E-4 3.830E-2
2.772E-1
6.031E-1
 4 29
15 HP:0002645 Wormian bones 7.742E-4 3.830E-2
2.772E-1
6.031E-1
 4 29
16 HP:0003040 Arthropathy 7.867E-4 3.830E-2
2.772E-1
6.129E-1
 3 13
17 HP:0000974 Hyperextensible skin 8.835E-4 4.048E-2
2.929E-1
6.882E-1
 4 30
18 HP:0002691 Platybasia 1.259E-3 4.734E-2
3.425E-1
9.811E-1
 2 4
19 HP:0000675 Macrodontia of permanent maxillary central incisor 1.259E-3 4.734E-2
3.425E-1
9.811E-1
 2 4
20 HP:0001742 Nasal obstruction {has synonym type="layperson"} 1.259E-3 4.734E-2
3.425E-1
9.811E-1
 2 4
21 HP:0000212 Gingival overgrowth 1.276E-3 4.734E-2
3.425E-1
9.941E-1
 4 33
Show 16 more annotations

5: Mouse Phenotype [Display Chart] 3063 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000130 abnormal trabecular bone morphology 1.129E-8 2.046E-5 1.761E-4 3.458E-5 20 286
2 MP:0000163 abnormal cartilage morphology 1.336E-8 2.046E-5 1.761E-4 4.092E-5 23 381
3 MP:0002113 abnormal skeleton development 9.641E-8 9.844E-5 8.470E-4 2.953E-4 25 494
4 MP:0004686 decreased length of long bones 1.293E-7 9.902E-5 8.520E-4 3.961E-4 20 331
5 MP:0005006 abnormal osteoblast physiology 9.116E-7 4.950E-4 4.259E-3 2.792E-3 9 69
6 MP:0000454 abnormal jaw morphology 9.696E-7 4.950E-4 4.259E-3 2.970E-3 22 446
7 MP:0005503 abnormal tendon morphology 1.707E-6 6.982E-4 6.008E-3 5.228E-3 7 39
8 MP:0003055 abnormal long bone epiphyseal plate morphology 1.824E-6 6.982E-4 6.008E-3 5.586E-3 14 198
9 MP:0000458 abnormal mandible morphology 2.752E-6 9.367E-4 8.060E-3 8.430E-3 14 205
10 MP:0004016 decreased bone mass 3.229E-6 9.892E-4 8.511E-3 9.892E-3 10 102
11 MP:0006395 abnormal epiphyseal plate morphology 5.356E-6 1.491E-3 1.283E-2 1.640E-2 14 217
12 MP:0003797 abnormal compact bone morphology 1.114E-5 2.843E-3 2.447E-2 3.412E-2 12 171
13 MP:0000164 abnormal cartilage development 1.659E-5 3.910E-3 3.364E-2
5.083E-2
 13 208
14 MP:0003279 aneurysm 1.837E-5 4.019E-3 3.458E-2
5.627E-2
 7 55
15 MP:0002100 abnormal tooth morphology 2.478E-5 4.915E-3 4.229E-2
7.589E-2
 13 216
16 MP:0008271 abnormal bone ossification 2.568E-5 4.915E-3 4.229E-2
7.865E-2
 19 428
17 MP:0000166 abnormal chondrocyte morphology 2.812E-5 5.066E-3 4.359E-2
8.612E-2
 9 104
18 MP:0002115 abnormal limb bone morphology 3.206E-5 5.455E-3 4.694E-2
9.819E-2
 20 474
19 MP:0000109 abnormal parietal bone morphology 5.015E-5 8.085E-3
6.957E-2
1.536E-1
 7 64
20 MP:0011504 abnormal limb long bone morphology 5.417E-5 8.296E-3
7.139E-2
1.659E-1
 19 452
21 MP:0003935 abnormal craniofacial development 6.646E-5 9.694E-3
8.341E-2
2.036E-1
 17 381
22 MP:0009888 palatal shelves fail to meet at midline 1.167E-4 1.563E-2
1.345E-1
3.575E-1
 6 51
23 MP:0009887 abnormal palatal shelf fusion at midline 1.173E-4 1.563E-2
1.345E-1
3.594E-1
 7 73
24 MP:0003756 abnormal hard palate morphology 1.269E-4 1.619E-2
1.393E-1
3.887E-1
 9 126
25 MP:0003662 abnormal long bone epiphyseal plate proliferative zone 1.394E-4 1.707E-2
1.469E-1
4.269E-1
 7 75
26 MP:0010874 abnormal bone volume 1.466E-4 1.727E-2
1.486E-1
4.490E-1
 10 158
27 MP:0000556 abnormal hindlimb morphology 1.775E-4 1.955E-2
1.682E-1
5.437E-1
 17 413
28 MP:0000066 osteoporosis 1.787E-4 1.955E-2
1.682E-1
5.474E-1
 6 55
29 MP:0000167 decreased chondrocyte number 2.088E-4 2.137E-2
1.839E-1
6.395E-1
 4 20
30 MP:0000116 abnormal tooth development 2.094E-4 2.137E-2
1.839E-1
6.412E-1
 7 80
31 MP:0000272 abnormal aorta morphology 2.176E-4 2.150E-2
1.850E-1
6.667E-1
 12 232
32 MP:0000547 short limbs 2.267E-4 2.170E-2
1.867E-1
6.945E-1
 9 136
33 MP:0013630 increased bone trabecular spacing 2.738E-4 2.396E-2
2.062E-1
8.386E-1
 3 9
34 MP:0000158 absent sternum 2.738E-4 2.396E-2
2.062E-1
8.386E-1
 3 9
35 MP:0005359 growth retardation of incisors 2.738E-4 2.396E-2
2.062E-1
8.386E-1
 3 9
36 MP:0004592 small mandible 3.132E-4 2.665E-2
2.293E-1
9.593E-1
 9 142
37 MP:0005620 abnormal muscle contractility 3.622E-4 2.999E-2
2.580E-1
1.000E0
 16 398
38 MP:0005197 abnormal uvea morphology 4.028E-4 3.178E-2
2.734E-1
1.000E0
 10 179
39 MP:0004986 abnormal osteoblast morphology 4.046E-4 3.178E-2
2.734E-1
1.000E0
 9 147
40 MP:0010931 abnormal trabecular bone connectivity density 4.367E-4 3.183E-2
2.739E-1
1.000E0
 4 24
41 MP:0006429 abnormal hyaline cartilage morphology 4.367E-4 3.183E-2
2.739E-1
1.000E0
 4 24
42 MP:0010873 decreased trabecular bone mass 4.367E-4 3.183E-2
2.739E-1
1.000E0
 4 24
43 MP:0002933 joint inflammation 4.468E-4 3.183E-2
2.739E-1
1.000E0
 9 149
44 MP:0013545 cleft hard palate 4.641E-4 3.212E-2
2.763E-1
1.000E0
 7 91
45 MP:0010869 decreased bone trabecula number 4.882E-4 3.212E-2
2.763E-1
1.000E0
 6 66
46 MP:0000088 short mandible 4.960E-4 3.212E-2
2.763E-1
1.000E0
 7 92
47 MP:0002191 abnormal artery morphology 5.049E-4 3.212E-2
2.763E-1
1.000E0
 18 494
48 MP:0003560 osteoarthritis 5.138E-4 3.212E-2
2.763E-1
1.000E0
 4 25
49 MP:0008438 abnormal cutaneous collagen fibril morphology 5.138E-4 3.212E-2
2.763E-1
1.000E0
 4 25
50 MP:0011031 abnormal branching involved in terminal bronchiole morphogenesis 5.258E-4 3.221E-2
2.772E-1
1.000E0
 3 11
Show 45 more annotations

6: Domain [Display Chart] 1258 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR008160 Collagen InterPro 2.579E-6 1.622E-3 1.251E-2 3.244E-3 8 85
2 PF01391 Collagen Pfam 2.579E-6 1.622E-3 1.251E-2 3.244E-3 8 85
3 PS00142 ZINC PROTEASE PROSITE 7.529E-6 3.157E-3 2.436E-2 9.471E-3 8 98
4 IPR000742 EGF-like dom InterPro 1.084E-5 3.410E-3 2.631E-2 1.364E-2 12 250
5 IPR001762 Disintegrin dom InterPro 5.960E-5 8.742E-3
6.744E-2
7.497E-2
 5 41
6 IPR002209 Fibroblast GF fam InterPro 6.767E-5 8.742E-3
6.744E-2
8.513E-2
 4 22
7 SM00442 FGF SMART 6.767E-5 8.742E-3
6.744E-2
8.513E-2
 4 22
8 PF00167 FGF Pfam 6.767E-5 8.742E-3
6.744E-2
8.513E-2
 4 22
9 PS00247 HBGF FGF PROSITE 6.767E-5 8.742E-3
6.744E-2
8.513E-2
 4 22
10 PS00022 EGF 1 PROSITE 6.949E-5 8.742E-3
6.744E-2
8.742E-2
 11 256
11 IPR028142 IL-1 fam/FGF fam InterPro 8.127E-5 8.958E-3
6.911E-2
1.022E-1
 4 23
12 IPR013032 EGF-like CS InterPro 8.545E-5 8.958E-3
6.911E-2
1.075E-1
 11 262
13 PS01186 EGF 2 PROSITE 9.776E-5 9.460E-3
7.298E-2
1.230E-1
 11 266
14 PD002078 Fib collagen C ProDom 1.646E-4 1.101E-2
8.492E-2
2.070E-1
 3 11
15 PS51461 NC1 FIB PROSITE 1.646E-4 1.101E-2
8.492E-2
2.070E-1
 3 11
16 IPR000885 Fib collagen C InterPro 1.646E-4 1.101E-2
8.492E-2
2.070E-1
 3 11
17 PF01410 COLFI Pfam 1.646E-4 1.101E-2
8.492E-2
2.070E-1
 3 11
18 SM00038 COLFI SMART 1.646E-4 1.101E-2
8.492E-2
2.070E-1
 3 11
19 SM00181 EGF SMART 1.666E-4 1.101E-2
8.492E-2
2.096E-1
 10 236
20 3.40.390.10 - Gene3D 1.838E-4 1.101E-2
8.492E-2
2.312E-1
 6 81
21 IPR024079 MetalloPept cat dom InterPro 1.838E-4 1.101E-2
8.492E-2
2.312E-1
 6 81
22 IPR013524 Runt dom InterPro 3.113E-4 1.306E-2
1.007E-1
3.917E-1
 2 3
23 IPR000040 AML1 Runt InterPro 3.113E-4 1.306E-2
1.007E-1
3.917E-1
 2 3
24 IPR016554 TF Runt-rel RUNX InterPro 3.113E-4 1.306E-2
1.007E-1
3.917E-1
 2 3
25 PF00853 Runt Pfam 3.113E-4 1.306E-2
1.007E-1
3.917E-1
 2 3
26 4.10.770.10 - Gene3D 3.113E-4 1.306E-2
1.007E-1
3.917E-1
 2 3
27 IPR013711 RunxI C dom InterPro 3.113E-4 1.306E-2
1.007E-1
3.917E-1
 2 3
28 PS51062 RUNT PROSITE 3.113E-4 1.306E-2
1.007E-1
3.917E-1
 2 3
29 IPR027384 Runx central dom InterPro 3.113E-4 1.306E-2
1.007E-1
3.917E-1
 2 3
30 PF08504 RunxI Pfam 3.113E-4 1.306E-2
1.007E-1
3.917E-1
 2 3
31 PF00008 EGF Pfam 3.217E-4 1.306E-2
1.007E-1
4.048E-1
 7 126
32 PF00090 TSP 1 Pfam 4.659E-4 1.832E-2
1.413E-1
5.861E-1
 5 63
33 IPR008996 Cytokine IL1-like InterPro 4.872E-4 1.857E-2
1.433E-1
6.129E-1
 4 36
34 PS50092 TSP1 PROSITE 5.386E-4 1.882E-2
1.452E-1
6.775E-1
 5 65
35 SM00209 TSP1 SMART 5.386E-4 1.882E-2
1.452E-1
6.775E-1
 5 65
36 IPR000884 TSP1 rpt InterPro 5.386E-4 1.882E-2
1.452E-1
6.775E-1
 5 65
37 PF04706 Dickkopf N Pfam 6.185E-4 2.047E-2
1.579E-1
7.780E-1
 2 4
38 IPR006796 Dickkopf N InterPro 6.185E-4 2.047E-2
1.579E-1
7.780E-1
 2 4
39 PF01562 Pep M12B propep Pfam 6.642E-4 2.047E-2
1.579E-1
8.356E-1
 4 39
40 IPR002870 Peptidase M12B N InterPro 6.642E-4 2.047E-2
1.579E-1
8.356E-1
 4 39
41 PS00427 DISINTEGRIN 1 PROSITE 7.321E-4 2.047E-2
1.579E-1
9.210E-1
 4 40
42 PF01421 Reprolysin Pfam 7.321E-4 2.047E-2
1.579E-1
9.210E-1
 4 40
43 IPR001590 Peptidase M12B InterPro 7.321E-4 2.047E-2
1.579E-1
9.210E-1
 4 40
44 PS50215 ADAM MEPRO PROSITE 7.321E-4 2.047E-2
1.579E-1
9.210E-1
 4 40
45 PS50214 DISINTEGRIN 2 PROSITE 7.321E-4 2.047E-2
1.579E-1
9.210E-1
 4 40
46 PS50026 EGF 3 PROSITE 7.545E-4 2.063E-2
1.592E-1
9.492E-1
 9 236
47 IPR020436 Somatomedin B chordata InterPro 1.024E-3 2.740E-2
2.114E-1
1.000E0
 2 5
48 SM00231 FA58C SMART 1.230E-3 3.034E-2
2.341E-1
1.000E0
 3 21
49 PS01286 FA58C 2 PROSITE 1.230E-3 3.034E-2
2.341E-1
1.000E0
 3 21
50 PS50022 FA58C 3 PROSITE 1.230E-3 3.034E-2
2.341E-1
1.000E0
 3 21
Show 45 more annotations

7: Pathway [Display Chart] 1024 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 576262 Extracellular matrix organization BioSystems: REACTOME 2.128E-14 2.179E-11 1.636E-10 2.179E-11 24 264
2 M5884 Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans MSigDB C2 BIOCARTA (v5.1) 3.860E-12 1.976E-9 1.484E-8 3.952E-9 22 275
3 83068 ECM-receptor interaction BioSystems: KEGG 9.624E-9 3.285E-6 2.467E-5 9.855E-6 11 86
4 198812 Endochondral Ossification BioSystems: WikiPathways 1.276E-7 3.266E-5 2.452E-4 1.306E-4 9 66
5 833812 ECM proteoglycans BioSystems: REACTOME 3.929E-7 8.046E-5 6.042E-4 4.023E-4 8 55
6 833810 Non-integrin membrane-ECM interactions BioSystems: REACTOME 8.262E-7 1.410E-4 1.059E-3 8.461E-4 7 42
7 692234 PI3K-Akt signaling pathway BioSystems: KEGG 1.627E-6 2.231E-4 1.675E-3 1.666E-3 17 346
8 M3468 Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix MSigDB C2 BIOCARTA (v5.1) 1.791E-6 2.231E-4 1.675E-3 1.834E-3 14 238
9 83067 Focal adhesion BioSystems: KEGG 1.960E-6 2.231E-4 1.675E-3 2.007E-3 13 206
10 198795 Focal Adhesion BioSystems: WikiPathways 3.523E-6 3.215E-4 2.414E-3 3.608E-3 12 184
11 169349 Validated transcriptional targets of AP1 family members Fra1 and Fra2 BioSystems: Pathway Interaction Database 3.680E-6 3.215E-4 2.414E-3 3.768E-3 6 34
12 833811 Syndecan interactions BioSystems: REACTOME 3.997E-6 3.215E-4 2.414E-3 4.093E-3 5 20
13 712094 Cardiac Progenitor Differentiation BioSystems: WikiPathways 4.205E-6 3.215E-4 2.414E-3 4.306E-3 7 53
14 M5882 Genes encoding proteoglycans MSigDB C2 BIOCARTA (v5.1) 4.395E-6 3.215E-4 2.414E-3 4.501E-3 6 35
15 730306 Assembly of collagen fibrils and other multimeric structures BioSystems: REACTOME 4.780E-6 3.263E-4 2.451E-3 4.895E-3 7 54
16 782000 Proteoglycans in cancer BioSystems: KEGG 5.202E-6 3.330E-4 2.500E-3 5.327E-3 13 225
17 645288 Collagen formation BioSystems: REACTOME 1.343E-5 8.088E-4 6.073E-3 1.375E-2 8 87
18 PW:0000490 transforming growth factor-beta Smad dependent signaling Pathway Ontology 1.595E-5 9.075E-4 6.815E-3 1.634E-2 5 26
19 M3008 Genes encoding structural ECM glycoproteins MSigDB C2 BIOCARTA (v5.1) 3.730E-5 2.010E-3 1.509E-2 3.819E-2 11 196
20 P00034 Integrin signalling pathway PantherDB 4.926E-5 2.280E-3 1.712E-2
5.044E-2
 10 167
21 645281 Activated point mutants of FGFR2 BioSystems: REACTOME 5.122E-5 2.280E-3 1.712E-2
5.245E-2
 4 17
22 106349 FGFR2 ligand binding and activation BioSystems: REACTOME 5.122E-5 2.280E-3 1.712E-2
5.245E-2
 4 17
23 645280 Signaling by FGFR2 mutants BioSystems: REACTOME 5.122E-5 2.280E-3 1.712E-2
5.245E-2
 4 17
24 83105 Pathways in cancer BioSystems: KEGG 6.546E-5 2.793E-3 2.097E-2
6.703E-2
 14 327
25 106384 Signaling by PDGF BioSystems: REACTOME 8.837E-5 3.620E-3 2.718E-2
9.049E-2
 10 179
26 576263 Degradation of the extracellular matrix BioSystems: REACTOME 1.288E-4 5.073E-3 3.810E-2
1.319E-1
 7 89
27 645289 Collagen biosynthesis and modifying enzymes BioSystems: REACTOME 1.639E-4 6.217E-3 4.669E-2
1.679E-1
 6 65
28 106344 FGFR ligand binding and activation BioSystems: REACTOME 1.797E-4 6.344E-3 4.764E-2
1.840E-1
 4 23
29 906029 Laminin interactions BioSystems: REACTOME 1.797E-4 6.344E-3 4.764E-2
1.840E-1
 4 23
30 M3005 Genes encoding collagen proteins MSigDB C2 BIOCARTA (v5.1) 2.194E-4 7.490E-3
5.624E-2
2.247E-1
 5 44
31 137999 Integrins in angiogenesis BioSystems: Pathway Interaction Database 2.714E-4 8.966E-3
6.732E-2
2.779E-1
 5 46
32 106347 FGFR1c ligand binding and activation BioSystems: REACTOME 3.029E-4 9.398E-3
7.057E-2
3.101E-1
 3 11
33 645279 Signaling by activated point mutants of FGFR1 BioSystems: REACTOME 3.029E-4 9.398E-3
7.057E-2
3.101E-1
 3 11
34 413362 O-glycan biosynthesis, mucin type core BioSystems: KEGG 3.424E-4 1.031E-2
7.743E-2
3.506E-1
 4 27
35 106352 FGFR3 ligand binding and activation BioSystems: REACTOME 4.001E-4 1.078E-2
8.096E-2
4.097E-1
 3 12
36 106354 FGFR3c ligand binding and activation BioSystems: REACTOME 4.001E-4 1.078E-2
8.096E-2
4.097E-1
 3 12
37 645284 Signaling by activated point mutants of FGFR3 BioSystems: REACTOME 4.001E-4 1.078E-2
8.096E-2
4.097E-1
 3 12
38 645283 Signaling by FGFR3 mutants BioSystems: REACTOME 4.001E-4 1.078E-2
8.096E-2
4.097E-1
 3 12
39 137963 Regulation of nuclear SMAD2/3 signaling BioSystems: Pathway Interaction Database 4.458E-4 1.135E-2
8.521E-2
4.565E-1
 6 78
40 167324 Amoebiasis BioSystems: KEGG 4.519E-4 1.135E-2
8.521E-2
4.627E-1
 7 109
41 160960 SHC-mediated cascade BioSystems: REACTOME 4.544E-4 1.135E-2
8.521E-2
4.653E-1
 4 29
42 83064 TGF-beta signaling pathway BioSystems: KEGG 5.109E-4 1.227E-2
9.215E-2
5.231E-1
 6 80
43 106351 FGFR2c ligand binding and activation BioSystems: REACTOME 5.153E-4 1.227E-2
9.215E-2
5.277E-1
 3 13
44 82977 Mucin type O-Glycan biosynthesis BioSystems: KEGG 5.903E-4 1.374E-2
1.032E-1
6.044E-1
 4 31
45 198810 TGF Beta Signaling Pathway BioSystems: WikiPathways 6.289E-4 1.431E-2
1.075E-1
6.440E-1
 5 55
46 106345 FGFR1 ligand binding and activation BioSystems: REACTOME 6.498E-4 1.446E-2
1.086E-1
6.654E-1
 3 14
47 160959 Phospholipase C-mediated cascade BioSystems: REACTOME 6.837E-4 1.490E-2
1.119E-1
7.001E-1
 5 56
48 685535 Constitutive PI3K/AKT Signaling in Cancer BioSystems: REACTOME 7.988E-4 1.704E-2
1.280E-1
8.180E-1
 6 87
49 730350 Antagonism of Activin by Follistatin BioSystems: REACTOME 9.363E-4 1.957E-2
1.469E-1
9.588E-1
 2 4
50 160958 FRS2-mediated cascade BioSystems: REACTOME 1.427E-3 2.865E-2
2.151E-1
1.000E0
 4 39
Show 45 more annotations

8: Pubmed [Display Chart] 34476 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20551380 Proteomics characterization of extracellular space components in the human aorta. Pubmed 2.918E-18 1.006E-13 1.109E-12 1.006E-13 14 101
2 19453261:gr High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. GeneRIF 4.598E-17 5.284E-13 5.826E-12 1.585E-12 20 383
3 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 4.598E-17 5.284E-13 5.826E-12 1.585E-12 20 383
4 20628624:gr Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". GeneRIF 2.210E-16 1.524E-12 1.680E-11 7.619E-12 15 172
5 20628624 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". Pubmed 2.210E-16 1.524E-12 1.680E-11 7.619E-12 15 172
6 20634891:gr Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. GeneRIF 8.892E-16 4.379E-12 4.828E-11 3.066E-11 18 331
7 20634891 Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Pubmed 8.892E-16 4.379E-12 4.828E-11 3.066E-11 18 331
8 19578796:gr Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. GeneRIF 7.761E-13 2.973E-9 3.278E-8 2.676E-8 12 152
9 19578796 Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. Pubmed 7.761E-13 2.973E-9 3.278E-8 2.676E-8 12 152
10 22261194 Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Pubmed 3.013E-12 1.039E-8 1.145E-7 1.039E-7 9 64
11 20485444:gr Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. GeneRIF 2.497E-11 7.172E-8 7.908E-7 8.607E-7 10 115
12 20485444 Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. Pubmed 2.497E-11 7.172E-8 7.908E-7 8.607E-7 10 115
13 21665990 Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Pubmed 2.135E-9 5.421E-6 5.977E-5 7.360E-5 5 15
14 12008951:gr Differential effects of fibroblast growth factors on expression of genes of the plasminogen activator and insulin-like growth factor systems by human breast fibroblasts. GeneRIF 2.952E-9 5.421E-6 5.977E-5 1.018E-4 4 6
15 12008951 Differential effects of fibroblast growth factors on expression of genes of the plasminogen activator and insulin-like growth factor systems by human breast fibroblasts. Pubmed 2.952E-9 5.421E-6 5.977E-5 1.018E-4 4 6
16 20673868:gr A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). GeneRIF 2.987E-9 5.421E-6 5.977E-5 1.030E-4 10 187
17 20673868 A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Pubmed 2.987E-9 5.421E-6 5.977E-5 1.030E-4 10 187
18 20385826 Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Pubmed 3.096E-9 5.421E-6 5.977E-5 1.067E-4 5 16
19 20452482 Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. Pubmed 3.145E-9 5.421E-6 5.977E-5 1.084E-4 10 188
20 20452482:gr Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. GeneRIF 3.145E-9 5.421E-6 5.977E-5 1.084E-4 10 188
21 19834535 Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. Pubmed 4.606E-9 6.616E-6 7.294E-5 1.588E-4 8 99
22 19730683:gr The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. GeneRIF 4.606E-9 6.616E-6 7.294E-5 1.588E-4 8 99
23 19834535:gr Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. GeneRIF 4.606E-9 6.616E-6 7.294E-5 1.588E-4 8 99
24 19730683 The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. Pubmed 4.606E-9 6.616E-6 7.294E-5 1.588E-4 8 99
25 20385819 Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Pubmed 6.035E-9 8.323E-6 9.176E-5 2.081E-4 5 18
26 15599946 The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican. Pubmed 6.868E-9 8.769E-6 9.668E-5 2.368E-4 4 7
27 15599946:gr The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican. GeneRIF 6.868E-9 8.769E-6 9.668E-5 2.368E-4 4 7
28 23658023 Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. Pubmed 1.306E-8 1.608E-5 1.773E-4 4.504E-4 7 73
29 17146610:gr Expression of decorin and collagens I and III in different layers of human skin in vivo: a laser capture microdissection study. GeneRIF 5.319E-8 5.556E-5 6.126E-4 1.834E-3 3 3
30 21558389:gr PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis. GeneRIF 5.319E-8 5.556E-5 6.126E-4 1.834E-3 3 3
31 15336555 Pancreatic tumor cells influence the composition of the extracellular matrix. Pubmed 5.319E-8 5.556E-5 6.126E-4 1.834E-3 3 3
32 17146610 Expression of decorin and collagens I and III in different layers of human skin in vivo: a laser capture microdissection study. Pubmed 5.319E-8 5.556E-5 6.126E-4 1.834E-3 3 3
33 15336555:gr Pancreatic tumor cells influence the composition of the extracellular matrix. GeneRIF 5.319E-8 5.556E-5 6.126E-4 1.834E-3 3 3
34 20385819:gr Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. GeneRIF 6.399E-8 6.488E-5 7.154E-4 2.206E-3 4 11
35 15340161 Signal peptide prediction based on analysis of experimentally verified cleavage sites. Pubmed 7.858E-8 7.740E-5 8.534E-4 2.709E-3 10 264
36 23455636 Seven new loci associated with age-related macular degeneration. Pubmed 9.675E-8 9.265E-5 1.022E-3 3.336E-3 5 30
37 21546767 Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. Pubmed 1.359E-7 1.218E-4 1.343E-3 4.685E-3 5 32
38 8663044 Receptor specificity of the fibroblast growth factor family. Pubmed 1.378E-7 1.218E-4 1.343E-3 4.752E-3 4 13
39 20301299 Thoracic Aortic Aneurysms and Aortic Dissections Pubmed 1.378E-7 1.218E-4 1.343E-3 4.752E-3 4 13
40 21423176 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for Ã?-Pix in negative regulation of focal adhesion maturation. Pubmed 1.651E-7 1.423E-4 1.568E-3 5.690E-3 10 286
41 17133345 Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells. Pubmed 1.924E-7 1.590E-4 1.753E-3 6.632E-3 4 14
42 22735305:gr Expression of ADAMTS-1, ADAMTS-4, ADAMTS-5 and TIMP3 by hepatocellular carcinoma cell lines. GeneRIF 2.121E-7 1.590E-4 1.753E-3 7.314E-3 3 4
43 22735305 Expression of ADAMTS-1, ADAMTS-4, ADAMTS-5 and TIMP3 by hepatocellular carcinoma cell lines. Pubmed 2.121E-7 1.590E-4 1.753E-3 7.314E-3 3 4
44 23457216:gr HSulf sulfatases catalyze processive and oriented 6-O-desulfation of heparan sulfate that differentially regulates fibroblast growth factor activity. GeneRIF 2.121E-7 1.590E-4 1.753E-3 7.314E-3 3 4
45 23457216 HSulf sulfatases catalyze processive and oriented 6-O-desulfation of heparan sulfate that differentially regulates fibroblast growth factor activity. Pubmed 2.121E-7 1.590E-4 1.753E-3 7.314E-3 3 4
46 22277757:gr ERK acts in parallel to PKC¿ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts. GeneRIF 2.121E-7 1.590E-4 1.753E-3 7.314E-3 3 4
47 20672350:gr Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. GeneRIF 2.513E-7 1.805E-4 1.990E-3 8.663E-3 5 36
48 20672350 Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. Pubmed 2.513E-7 1.805E-4 1.990E-3 8.663E-3 5 36
49 24804215 Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line. Pubmed 3.477E-7 2.446E-4 2.697E-3 1.199E-2 4 16
50 11311202 Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53. Pubmed 5.812E-7 3.957E-4 4.363E-3 2.004E-2 4 18
Show 45 more annotations

9: Interaction [Display Chart] 2522 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:COL1A1 COL1A1 interactions 1.949E-7 4.916E-4 4.135E-3 4.916E-4 8 58
2 int:THBS1 THBS1 interactions 9.073E-7 9.036E-4 7.600E-3 2.288E-3 7 49
3 int:ACAN ACAN interactions 1.075E-6 9.036E-4 7.600E-3 2.711E-3 5 18
4 int:MMP2 MMP2 interactions 3.591E-6 2.264E-3 1.904E-2 9.056E-3 6 39
5 int:SPARC SPARC interactions 6.268E-6 3.162E-3 2.659E-2 1.581E-2 5 25
6 int:UBQLN4 UBQLN4 interactions 3.557E-5 1.495E-2
1.258E-1
8.972E-2
 10 186
7 int:COL1A2 COL1A2 interactions 5.284E-5 1.878E-2
1.580E-1
1.333E-1
 5 38
8 int:FGFR4 FGFR4 interactions 6.008E-5 1.878E-2
1.580E-1
1.515E-1
 5 39
9 int:COL3A1 COL3A1 interactions 6.884E-5 1.878E-2
1.580E-1
1.736E-1
 4 21
10 int:NRP1 NRP1 interactions 7.685E-5 1.878E-2
1.580E-1
1.938E-1
 5 41
11 int:HAPLN1 HAPLN1 interactions 9.991E-5 1.878E-2
1.580E-1
2.520E-1
 3 9
12 int:FGFBP1 FGFBP1 interactions 9.991E-5 1.878E-2
1.580E-1
2.520E-1
 3 9
13 int:CD44 CD44 interactions 1.009E-4 1.878E-2
1.580E-1
2.544E-1
 6 69
14 int:ANPEP ANPEP interactions 1.166E-4 1.878E-2
1.580E-1
2.940E-1
 2 2
15 int:TGFBR3 TGFBR3 interactions 1.192E-4 1.878E-2
1.580E-1
3.005E-1
 4 24
16 int:MMP14 MMP14 interactions 1.192E-4 1.878E-2
1.580E-1
3.005E-1
 4 24
17 int:HLA-DMA HLA-DMA interactions 1.416E-4 2.089E-2
1.757E-1
3.571E-1
 3 10
18 int:FGFR1 FGFR1 interactions 1.491E-4 2.089E-2
1.757E-1
3.759E-1
 6 74
19 int:TGFB1 TGFB1 interactions 2.139E-4 2.839E-2
2.388E-1
5.395E-1
 6 79
20 int:PF4 PF4 interactions 2.555E-4 3.182E-2
2.676E-1
6.443E-1
 3 12
21 int:FGFR3 FGFR3 interactions 2.650E-4 3.182E-2
2.676E-1
6.683E-1
 5 53
22 int:COL4A4 COL4A4 interactions 3.295E-4 3.613E-2
3.038E-1
8.309E-1
 3 13
23 int:FST FST interactions 3.295E-4 3.613E-2
3.038E-1
8.309E-1
 3 13
24 int:COL6A3 COL6A3 interactions 3.472E-4 3.648E-2
3.068E-1
8.756E-1
 2 3
25 int:MMP9 MMP9 interactions 4.780E-4 4.819E-2
4.053E-1
1.000E0
 4 34
26 int:FBN1 FBN1 interactions 5.159E-4 4.819E-2
4.053E-1
1.000E0
 3 15
27 int:LRFN3 LRFN3 interactions 5.159E-4 4.819E-2
4.053E-1
1.000E0
 3 15
Show 22 more annotations

10: Cytoband [Display Chart] 164 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15q23-q24 15q23-q24 3.019E-4 4.952E-2
2.813E-1
 4.952E-2 2 5

11: Transcription Factor Binding Site [Display Chart] 493 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 104 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 471 CD molecules|V-set domain containing|Immunoglobulin like domain containing|Carcinoembryonic antigen related cell adhesion molecule family genenames.org 4.600E-6 4.784E-4 2.500E-3 4.784E-4 13 394
2 490 Collagens genenames.org 1.800E-5 9.359E-4 4.892E-3 1.872E-3 5 46
3 50 ADAM metallopeptidases with thrombospondin type 1 motif genenames.org 3.105E-4 1.023E-2
5.348E-2
 3.230E-2 3 19
4 870 Minor histocompatibility antigens genenames.org 4.657E-4 1.023E-2
5.348E-2
 4.844E-2 4 51
5 1324 STEAP family genenames.org 4.919E-4 1.023E-2
5.348E-2
5.116E-2
 2 5
6 593 CD molecules|V-set domain containing|I-set domain containing|Sialic acid binding Ig like lectins genenames.org 1.016E-3 1.761E-2
9.205E-2
1.057E-1
 6 161
7 441 Glucosaminyl (N-acetyl) transferases/xylosyltransferases genenames.org 1.358E-3 1.971E-2
1.030E-1
1.413E-1
 2 8
8 542 Endogenous ligands genenames.org 1.516E-3 1.971E-2
1.030E-1
1.577E-1
 7 237
9 492 Complement system genenames.org 2.096E-3 2.422E-2
1.266E-1
2.179E-1
 3 36
10 626 Laminin subunits genenames.org 3.143E-3 2.971E-2
1.553E-1
3.268E-1
 2 12
11 573 Small leucine rich repeat proteoglycans genenames.org 3.143E-3 2.971E-2
1.553E-1
3.268E-1
 2 12
12 555 Fibronectin type III domain containing|Immunoglobulin like domain containing genenames.org 5.672E-3 4.916E-2
2.569E-1
5.899E-1
 5 160
Show 7 more annotations

13: Coexpression [Display Chart] 6600 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M17471 Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS, non-invasive). MSigDB C2: CGP Curated Gene Sets (v5.1) 9.725E-42 6.419E-38 6.016E-37 6.419E-38 47 351
2 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v5.1) 3.309E-41 1.092E-37 1.023E-36 2.184E-37 39 200
3 M2256 Genes commonly down-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313 ,2078]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.785E-37 3.926E-34 3.679E-33 1.178E-33 38 227
4 M13256 Genes down-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.655E-36 7.681E-33 7.199E-32 3.073E-32 35 190
5 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.821E-34 1.164E-30 1.091E-29 5.822E-30 37 260
6 M2572 Genes in the 'mesenchymal transition signature' common to all invasive cancer types. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.744E-33 3.018E-30 2.828E-29 1.811E-29 24 64
7 M1804 Genes up-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.664E-24 9.112E-21 8.539E-20 6.378E-20 30 280
8 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.555E-20 1.283E-17 1.202E-16 1.026E-16 33 460
9 M17079 Up-regulated genes distinguishing between two subtypes of gastric cancer: advanced (AGC) and early (EGC). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.967E-20 1.442E-17 1.352E-16 1.298E-16 23 175
10 M19541 Genes commonly down-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.745E-20 3.132E-17 2.935E-16 3.132E-16 31 408
11 M2573 Genes consistently up-regulated in mammary stem cells both in mouse and human species. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.698E-18 5.219E-15 4.891E-14 5.741E-14 31 489
12 M2128 Genes up-regulated in growing IMR90 cells (fibroblast) after knockdown of RB1 [GeneID=5925] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.449E-17 1.897E-14 1.778E-13 2.276E-13 23 243
13 M9893 Genes whose expression increases with age in normal kidney, excluding those with higher expression in blood. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.928E-17 3.009E-14 2.820E-13 3.912E-13 22 221
14 M14555 Down-regulated at any timepoint following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v5.1) 9.256E-17 4.364E-14 4.090E-13 6.109E-13 18 128
15 M4065 Down-regulated at 24 h following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v5.1) 1.245E-16 5.478E-14 5.134E-13 8.217E-13 16 91
16 M12225 Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.741E-16 7.183E-14 6.732E-13 1.149E-12 21 205
17 M10165 Genes up-regulated in lobular carcinoma vs normal ductal breast cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.263E-15 4.905E-13 4.597E-12 8.338E-12 14 69
18 M13867 Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.341E-15 4.916E-13 4.607E-12 8.848E-12 22 256
19 M12890 Genes up-regulated in HT1080 cells (fibrosarcoma) over-expressing MMP14 [GeneID=4323] compared to those with knockdown of the gene by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.991E-15 1.039E-12 9.737E-12 1.974E-11 22 266
20 M2395 Genes up-regulated in pancreatic islets upon knockout of HNF1A [GeneID=6927]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.246E-15 2.391E-12 2.241E-11 4.782E-11 18 163
21 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.107E-14 3.479E-12 3.261E-11 7.306E-11 26 425
22 M3645 Genes up-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.933E-14 8.800E-12 8.247E-11 1.936E-10 26 443
23 M13547 Genes down-regulated in lobular carcinoma vs normal lobular breast cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.801E-14 2.813E-11 2.636E-10 6.469E-10 13 74
24 M7514 Genes down-regulated in NIH3T3 cells (fibroblasts) transformed by expression of contitutively active (Q63L) form of RHOA [GeneID=387] off plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.380E-13 3.796E-11 3.557E-10 9.109E-10 24 394
25 M2782 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 [Gene ID=648] gene by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 3.018E-13 7.967E-11 7.466E-10 1.992E-9 16 147
26 M3654 Genes up-regulated in samples with systolic heart failure compared to normal hearts. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.077E-13 1.543E-10 1.446E-9 4.011E-9 24 422
27 M8544 Up-regualted genes from the set F (Fig. 5a): specific signature shared by cells expressing AF4-MLL [GeneID=4299;4297] alone and those expressing both AF4-MLL and MLL-AF4 fusion proteins. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.756E-13 2.140E-10 2.006E-9 5.779E-9 17 185
28 M6239 Genes down-regulated in Cockayne syndrome fibroblasts rescued by expression of ERCC6 [GeneID=2074] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.281E-12 3.019E-10 2.830E-9 8.453E-9 10 39
29 M2779 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 and PCGF2 [Gene ID=648, 7703] genes by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 3.601E-12 8.195E-10 7.680E-9 2.376E-8 15 145
30 M19432 Genes up-regulated during pubertal mammary gland development between week 4 and 5. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.810E-12 1.058E-9 9.919E-9 3.175E-8 19 271
31 M4995 Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.990E-12 1.488E-9 1.395E-8 4.613E-8 22 390
32 M2446 Genes down-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 10 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.686E-12 1.585E-9 1.486E-8 5.073E-8 18 244
33 M13186 Genes up-regulated during pubertal mammary gland development between weeks 3 and 4. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.240E-12 1.848E-9 1.732E-8 6.098E-8 17 214
34 M5389 Genes whose expression increases with age in normal kidney. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.207E-11 2.344E-9 2.196E-8 7.968E-8 24 486
35 M14507 Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.000E-11 3.771E-9 3.534E-8 1.320E-7 23 454
36 M1124 Pubertal genes up-regulated by TGFB1 [GeneID=7040]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.318E-11 6.023E-9 5.645E-8 2.190E-7 15 169
37 M2784 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of PCGF2 [Gene ID=7703] gene by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 3.377E-11 6.023E-9 5.645E-8 2.229E-7 14 141
38 M5600 Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells versus those treated with IL1B [GeneID=3553] and IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v5.1) 3.472E-11 6.031E-9 5.652E-8 2.292E-7 16 200
39 M8689 Top 200 marker genes down-regulated in the 'CTNNB1' subclass of hepatocellular carcinoma (HCC); characterized by activated CTNNB1 [GeneID=1499]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.611E-11 6.111E-9 5.727E-8 2.383E-7 15 170
40 M17072 Up-regulated genes detecting gender effects in global expression profiling studies. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.825E-11 6.311E-9 5.915E-8 2.525E-7 6 9
41 M5942 Genes down-regulated in response to ultraviolet (UV) radiation. MSigDB H: Hallmark Gene Sets (v5.1) 4.494E-11 7.234E-9 6.780E-8 2.966E-7 14 144
42 M18938 Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of both HDAC1 and HDAC2 [GeneID=3065;3066] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.999E-11 7.856E-9 7.363E-8 3.300E-7 17 238
43 M13630 Selected genes down-regulated in WS1 (fibroblast) in response to irradiation with high dose UV-C. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.555E-11 8.527E-9 7.991E-8 3.667E-7 19 312
44 M1767 Cluster B: genes down-regulated in primary lung tumors driven by KRAS [GeneID=3845] activation and loss of STK11 [GeneID=6794]; also up-regulated in human squamous cell carcinoma (SCC) vs adenocarcinoma subtype of NSCLC (non-small cell lung cancer). MSigDB C2: CGP Curated Gene Sets (v5.1) 7.260E-11 1.089E-8 1.021E-7 4.791E-7 7 17
45 M5126 Down-regulated genes in head and neck cancer compared to cervical carcinoma samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.266E-10 1.857E-8 1.740E-7 8.356E-7 8 29
46 M4680 Genes up-regulated in RD cells (embryonal rhabdomyosarcoma, ERMS) by expression of PAX3- or PAX7-FOXO1 [GeneID=5077;5081;2308] fusions off retroviral vectors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.474E-10 2.114E-8 1.982E-7 9.726E-7 17 255
47 M13251 Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 14 h time point that were not down-regulated at the previous time point, 12 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.972E-10 2.742E-8 2.570E-7 1.301E-6 18 297
48 M4306 Genes down-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.994E-10 2.742E-8 2.570E-7 1.316E-6 22 464
49 M2259 Partial list of genes up-regulated in the kidney of GLIS2 [GeneID=84662] knockout mice compared to the wild type. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.251E-10 3.033E-8 2.842E-7 1.486E-6 11 84
50 M2445 Genes up-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 10 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.366E-10 4.444E-8 4.165E-7 2.222E-6 15 199
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 3505 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PCBC ctl CardiacMyocyte 500 Progenitor-Cell-Biology-Consortium reference CardiacMyocyte top-relative-expression-ranked 500 PCBC 3.039E-42 1.065E-38 9.308E-38 1.065E-38 54 495
2 JC fibro 1000 K1 JC fibro top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 9.654E-39 1.554E-35 1.358E-34 3.384E-35 50 464
3 PCBC ctl BronchSmoothMuscl 500 Progenitor-Cell-Biology-Consortium reference BronchSmoothMuscl top-relative-expression-ranked 500 PCBC 1.330E-38 1.554E-35 1.358E-34 4.663E-35 51 494
4 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 2.206E-37 1.933E-34 1.689E-33 7.731E-34 49 467
5 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 2.850E-36 1.998E-33 1.746E-32 9.990E-33 47 438
6 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 5.957E-36 3.480E-33 3.041E-32 2.088E-32 47 445
7 JC fibro 500 K3 JC fibro top-relative-expression-ranked 500 k-means-cluster#3 PCBC 1.694E-35 8.482E-33 7.413E-32 5.937E-32 36 206
8 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 2.611E-34 1.144E-31 9.997E-31 9.151E-31 46 455
9 JC fibro 500 JC fibro top-relative-expression-ranked 500 PCBC 2.519E-30 9.809E-28 8.572E-27 8.828E-27 44 497
10 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.931E-28 1.728E-25 1.511E-24 1.728E-24 39 410
11 gudmap kidney adult RenalCapsule k2 1000 kidney adult RenalCapsule k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.430E-27 7.744E-25 6.768E-24 8.518E-24 37 371
12 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 2.100E-26 6.133E-24 5.360E-23 7.359E-23 39 453
13 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 4.807E-25 1.296E-22 1.133E-21 1.685E-21 38 461
14 gudmap kidney adult RenalCapsule k1 500 kidney adult RenalCapsule k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.367E-22 3.423E-20 2.992E-19 4.793E-19 28 242
15 54Dn SubClass 54Dn 1SK Top 500 Cluster 2 54Dn SubClass 54Dn 1SK Top 500 Cluster 2 Brain Map - Allen iN 1.679E-21 3.924E-19 3.430E-18 5.887E-18 28 265
16 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB 500 dev gonad e13.5 F VascAssocMesenchStromOvary MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.878E-21 8.496E-19 7.425E-18 1.359E-17 31 358
17 GSM777046 100 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 4.206E-20 8.672E-18 7.579E-17 1.474E-16 19 97
18 gudmap dev gonad e13.5 M InterstitTestis Sma 500 dev gonad e13.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.220E-20 1.157E-17 1.011E-16 2.180E-16 30 362
19 gudmap kidney adult RenalCapsule 200 kidney adult RenalCapsule top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 6.273E-20 1.157E-17 1.011E-16 2.199E-16 23 176
20 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 5.581E-19 9.781E-17 8.548E-16 1.956E-15 33 494
21 endothelial SubClass DCN-hi Top 500 All endothelial SubClass DCN-hi Top 500 All Brain Map - Barres 5.934E-19 9.904E-17 8.655E-16 2.080E-15 33 495
22 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 6.308E-19 1.005E-16 8.783E-16 2.211E-15 33 496
23 GSM777043 100 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 1.179E-18 1.797E-16 1.571E-15 4.134E-15 18 97
24 gudmap developingGonad e18.5 epididymis 1000 k5 DevelopingGonad e18.5 epididymis emap-13166 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.992E-18 4.370E-16 3.819E-15 1.049E-14 24 234
25 gudmap dev gonad e13.5 M InterstitFLeydig MafB 500 dev gonad e13.5 M InterstitFLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.711E-18 6.605E-16 5.772E-15 1.651E-14 28 356
26 ratio EB vs SC 1000 K1 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 1.126E-17 1.518E-15 1.327E-14 3.947E-14 27 336
27 facebase RNAseq e14.5 palate poster nasal Tgfbr2 WT 2500 K4 facebase RNAseq e14.5 palate poster nasal Tgfbr2 WT 2500 K4 Gudmap RNAseq 2.123E-17 2.755E-15 2.408E-14 7.439E-14 17 95
28 gudmap dev gonad e12.5 M InterstitLeydig MafB 500 dev gonad e12.5 M InterstitLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.529E-17 1.068E-14 9.330E-14 2.989E-13 27 364
29 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma k4 1000 dev gonad e13.5 F VascAssocMesenchStromOvary Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.178E-16 1.424E-14 1.244E-13 4.129E-13 20 168
30 gudmap dev gonad e12.5 M InterstitTestis Sma 500 dev gonad e12.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.683E-16 1.966E-14 1.719E-13 5.899E-13 27 374
31 OPC Top 500 All OPC Top 500 All Brain Map - Barres 3.489E-16 3.944E-14 3.447E-13 1.223E-12 30 494
32 PCBC ctl BronchSmoothMuscl 100 Progenitor-Cell-Biology-Consortium reference BronchSmoothMuscl top-relative-expression-ranked 100 PCBC 1.045E-15 1.144E-13 1.000E-12 3.662E-12 16 99
33 gudmap dev gonad e13.5 M InterstitFLeydig MafB k3 1000 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.193E-15 1.267E-13 1.108E-12 4.182E-12 25 336
34 gudmap dev gonad e12.5 M InterstitLeydig MafB k1 1000 dev gonad e12.5 M InterstitLeydig MafB k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.037E-15 2.100E-13 1.836E-12 7.141E-12 24 311
35 gudmap developingGonad e16.5 epididymis 1000 k5 DevelopingGonad e16.5 epididymis emap-29702 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.696E-15 2.700E-13 2.359E-12 9.449E-12 20 197
36 astrocytes Top 500 All astrocytes Top 500 All Brain Map - Barres 3.058E-15 2.977E-13 2.602E-12 1.072E-11 29 496
37 gudmap dev gonad e12.5 F VasAssMesen MafB 500 dev gonad e12.5 F VasAssMesen MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.032E-15 3.820E-13 3.338E-12 1.413E-11 26 389
38 gudmap kidney e15.5 Podocyte MafB k2 1000 kidney e15.5 Podocyte MafB k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.225E-15 4.820E-13 4.212E-12 1.831E-11 15 90
39 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB k2 1000 dev gonad e13.5 F VascAssocMesenchStromOvary MafB k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 7.699E-15 6.920E-13 6.047E-12 2.699E-11 22 266
40 gudmap kidney adult RenalCapsule k3 200 kidney adult RenalCapsule k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 7.913E-15 6.933E-13 6.059E-12 2.773E-11 16 112
41 gudmap dev gonad e13.5 M InterstitFLeydig MafB k4 500 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.227E-15 7.033E-13 6.146E-12 2.883E-11 19 182
42 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma 500 dev gonad e13.5 F VascAssocMesenchStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.328E-14 1.108E-12 9.687E-12 4.656E-11 25 373
43 ratio EB vs SC 500 K5 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 500 k-means-cluster#5 PCBC 1.399E-14 1.140E-12 9.963E-12 4.902E-11 16 116
44 gudmap kidney e15.5 Podocyte MafB 500 kidney e15.5 Podocyte MafB top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.662E-14 1.324E-12 1.157E-11 5.827E-11 26 413
45 gudmap dev gonad e11.5 M GonadVasMes Flk 500 dev gonad e11.5 M GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.333E-14 1.817E-12 1.588E-11 8.179E-11 26 419
46 PCBC ratio EB vs SC 500 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 500 PCBC 2.678E-14 2.040E-12 1.783E-11 9.386E-11 28 499
47 gudmap dev gonad e11.5 F GonadVasMes Flk 500 dev gonad e11.5 F GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.082E-14 2.298E-12 2.009E-11 1.080E-10 26 424
48 gudmap dev gonad e11.5 M GonMes Sma 500 dev gonad e11.5 M GonMes Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 5.036E-14 3.678E-12 3.214E-11 1.765E-10 26 433
49 gudmap developingGonad P2 epididymis 1000 k2 DevelopingGonad P2 epididymis emap-30199 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.300E-14 3.791E-12 3.313E-11 1.858E-10 20 230
50 GSM777050 100 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 7.220E-14 5.061E-12 4.423E-11 2.531E-10 14 87
Show 45 more annotations

15: Computational [Display Chart] 342 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 8.511E-25 2.911E-22 1.867E-21 2.911E-22 33 216
2 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 1.400E-13 2.394E-11 1.536E-10 4.788E-11 29 378
3 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 3.012E-13 3.434E-11 2.202E-10 1.030E-10 28 361
4 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 4.345E-11 3.715E-9 2.382E-8 1.486E-8 25 351
5 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 8.099E-11 5.540E-9 3.553E-8 2.770E-8 27 423
6 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 8.034E-7 4.122E-5 2.643E-4 2.748E-4 21 419
7 module 122 Genes in module 122 MSigDb: C4 - CM: Cancer Modules 8.436E-7 4.122E-5 2.643E-4 2.885E-4 12 138
8 module 433 Genes in module 433 MSigDb: C4 - CM: Cancer Modules 2.503E-6 1.070E-4 6.861E-4 8.559E-4 8 60
9 module 220 Genes in module 220 MSigDb: C4 - CM: Cancer Modules 6.371E-6 2.421E-4 1.553E-3 2.179E-3 17 328
10 module 6 Genes in module 6 MSigDb: C4 - CM: Cancer Modules 7.982E-6 2.730E-4 1.751E-3 2.730E-3 19 407
11 module 107 Genes in module 107 MSigDb: C4 - CM: Cancer Modules 1.666E-5 5.181E-4 3.323E-3 5.699E-3 8 77
12 GNF2 CDH11 Neighborhood of CDH11 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.756E-5 7.854E-4 5.037E-3 9.425E-3 5 25
13 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 6.952E-5 1.829E-3 1.173E-2 2.378E-2 17 395
14 module 178 Genes in module 178 MSigDb: C4 - CM: Cancer Modules 9.388E-5 2.293E-3 1.471E-2 3.211E-2 4 17
15 module 33 Genes in module 33 MSigDb: C4 - CM: Cancer Modules 1.161E-4 2.490E-3 1.597E-2 3.970E-2 16 372
16 module 234 Genes in module 234 MSigDb: C4 - CM: Cancer Modules 1.218E-4 2.490E-3 1.597E-2 4.164E-2 6 53
17 module 38 Genes in module 38 MSigDb: C4 - CM: Cancer Modules 1.238E-4 2.490E-3 1.597E-2 4.232E-2 18 455
18 GNF2 PTX3 Neighborhood of PTX3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.716E-4 3.260E-3 2.091E-2
5.869E-2
 5 36
19 module 362 Genes in module 362 MSigDb: C4 - CM: Cancer Modules 2.255E-4 4.058E-3 2.603E-2
7.711E-2
 4 21
20 module 209 Genes in module 209 MSigDb: C4 - CM: Cancer Modules 2.701E-4 4.618E-3 2.962E-2
9.236E-2
 7 86
21 module 129 Genes in module 129 MSigDb: C4 - CM: Cancer Modules 3.620E-4 5.896E-3 3.781E-2
1.238E-1
 11 217
22 module 112 Genes in module 112 MSigDb: C4 - CM: Cancer Modules 4.139E-4 6.220E-3 3.989E-2
1.415E-1
 12 257
23 module 3 Genes in module 3 MSigDb: C4 - CM: Cancer Modules 4.183E-4 6.220E-3 3.989E-2
1.431E-1
 15 375
24 module 172 Genes in module 172 MSigDb: C4 - CM: Cancer Modules 4.371E-4 6.228E-3 3.994E-2
1.495E-1
 7 93
25 module 176 Genes in module 176 MSigDb: C4 - CM: Cancer Modules 5.303E-4 7.254E-3 4.652E-2
1.814E-1
 11 227
26 module 19 Genes in module 19 MSigDb: C4 - CM: Cancer Modules 6.044E-4 7.951E-3
5.099E-2
2.067E-1
 13 307
27 module 210 Genes in module 210 MSigDb: C4 - CM: Cancer Modules 7.118E-4 9.017E-3
5.783E-2
2.434E-1
 4 28
28 module 387 Genes in module 387 MSigDb: C4 - CM: Cancer Modules 7.442E-4 9.090E-3
5.830E-2
2.545E-1
 5 49
29 module 329 Genes in module 329 MSigDb: C4 - CM: Cancer Modules 8.953E-4 1.056E-2
6.772E-2
3.062E-1
 5 51
30 module 14 Genes in module 14 MSigDb: C4 - CM: Cancer Modules 1.264E-3 1.441E-2
9.244E-2
4.324E-1
 3 15
31 module 72 Genes in module 72 MSigDb: C4 - CM: Cancer Modules 1.472E-3 1.548E-2
9.930E-2
5.034E-1
 12 297
32 module 521 Genes in module 521 MSigDb: C4 - CM: Cancer Modules 1.505E-3 1.548E-2
9.930E-2
5.149E-1
 4 34
33 module 109 Genes in module 109 MSigDb: C4 - CM: Cancer Modules 1.505E-3 1.548E-2
9.930E-2
5.149E-1
 4 34
34 module 516 Genes in module 516 MSigDb: C4 - CM: Cancer Modules 1.539E-3 1.548E-2
9.930E-2
5.264E-1
 3 16
35 module 18 Genes in module 18 MSigDb: C4 - CM: Cancer Modules 1.934E-3 1.890E-2
1.212E-1
6.615E-1
 15 436
36 module 444 Genes in module 444 MSigDb: C4 - CM: Cancer Modules 2.195E-3 2.085E-2
1.337E-1
7.507E-1
 3 18
37 module 105 Genes in module 105 MSigDb: C4 - CM: Cancer Modules 2.303E-3 2.122E-2
1.361E-1
7.875E-1
 9 194
38 module 24 Genes in module 24 MSigDb: C4 - CM: Cancer Modules 2.358E-3 2.122E-2
1.361E-1
8.063E-1
 15 445
39 module 44 Genes in module 44 MSigDb: C4 - CM: Cancer Modules 2.674E-3 2.345E-2
1.504E-1
9.145E-1
 12 319
40 module 562 Genes in module 562 MSigDb: C4 - CM: Cancer Modules 3.463E-3 2.889E-2
1.853E-1
1.000E0
 3 21
41 module 58 Genes in module 58 MSigDb: C4 - CM: Cancer Modules 3.463E-3 2.889E-2
1.853E-1
1.000E0
 3 21
42 module 130 Genes in module 130 MSigDb: C4 - CM: Cancer Modules 4.514E-3 3.675E-2
2.357E-1
1.000E0
 3 23
43 module 99 Genes in module 99 MSigDb: C4 - CM: Cancer Modules 5.620E-3 4.458E-2
2.859E-1
1.000E0
 12 350
44 module 513 Genes in module 513 MSigDb: C4 - CM: Cancer Modules 5.735E-3 4.458E-2
2.859E-1
1.000E0
 2 8
Show 39 more annotations

16: MicroRNA [Display Chart] 1340 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CAGTATT,MIR-200B:MSigDB CAGTATT,MIR-200B:MSigDB MSigDB 1.144E-8 5.111E-6 3.975E-5 1.533E-5 20 434
2 CAGTATT,MIR-200C:MSigDB CAGTATT,MIR-200C:MSigDB MSigDB 1.144E-8 5.111E-6 3.975E-5 1.533E-5 20 434
3 CAGTATT,MIR-429:MSigDB CAGTATT,MIR-429:MSigDB MSigDB 1.144E-8 5.111E-6 3.975E-5 1.533E-5 20 434
4 miR-144:PicTar miR-144:PicTar PicTar 5.885E-8 1.971E-5 1.533E-4 7.886E-5 19 433
5 hsa-miR-452:PITA hsa-miR-452:PITA TOP PITA 1.112E-7 2.980E-5 2.318E-4 1.490E-4 19 451
6 miR-200b:PicTar miR-200b:PicTar PicTar 1.844E-7 3.648E-5 2.838E-4 2.471E-4 19 466
7 miR-200c:PicTar miR-200c:PicTar PicTar 1.906E-7 3.648E-5 2.838E-4 2.554E-4 19 467
8 hsa-miR-21:miRTarbase hsa-miR-21:miRTarbase miRTarbase 8.875E-7 1.329E-4 1.034E-3 1.189E-3 8 77
9 hsa-miR-410:TargetScan hsa-miR-410:TargetScan TargetScan 9.292E-7 1.329E-4 1.034E-3 1.245E-3 17 420
10 miR-199a-star:PicTar miR-199a-star:PicTar PicTar 9.918E-7 1.329E-4 1.034E-3 1.329E-3 17 422
11 miR-101:PicTar miR-101:PicTar PicTar 1.282E-6 1.562E-4 1.215E-3 1.718E-3 17 430
12 ATACTGT,MIR-144:MSigDB ATACTGT,MIR-144:MSigDB MSigDB 3.411E-6 3.809E-4 2.963E-3 4.571E-3 11 193
13 hsa-miR-1248:PITA hsa-miR-1248:PITA TOP PITA 4.159E-6 4.287E-4 3.335E-3 5.574E-3 12 237
14 hsa-miR-370:TargetScan hsa-miR-370:TargetScan TargetScan 4.534E-6 4.340E-4 3.375E-3 6.075E-3 12 239
15 hsa-miR-363:PITA hsa-miR-363:PITA TOP PITA 6.601E-6 4.783E-4 3.720E-3 8.846E-3 17 486
16 hsa-miR-25:PITA hsa-miR-25:PITA TOP PITA 6.782E-6 4.783E-4 3.720E-3 9.088E-3 17 487
17 hsa-miR-92a:PITA hsa-miR-92a:PITA TOP PITA 6.782E-6 4.783E-4 3.720E-3 9.088E-3 17 487
18 hsa-miR-367:PITA hsa-miR-367:PITA TOP PITA 6.782E-6 4.783E-4 3.720E-3 9.088E-3 17 487
19 hsa-miR-92b:PITA hsa-miR-92b:PITA TOP PITA 6.782E-6 4.783E-4 3.720E-3 9.088E-3 17 487
20 ACTGTGA,MIR-27B:MSigDB ACTGTGA,MIR-27B:MSigDB MSigDB 9.357E-6 5.971E-4 4.644E-3 1.254E-2 16 447
21 ACTGTGA,MIR-27A:MSigDB ACTGTGA,MIR-27A:MSigDB MSigDB 9.357E-6 5.971E-4 4.644E-3 1.254E-2 16 447
22 hsa-miR-758:TargetScan hsa-miR-758:TargetScan TargetScan 1.607E-5 9.786E-4 7.612E-3 2.153E-2 9 148
23 hsa-miR-32:PITA hsa-miR-32:PITA TOP PITA 2.246E-5 1.298E-3 1.010E-2 3.010E-2 16 480
24 TTTGCAC,MIR-19A:MSigDB TTTGCAC,MIR-19A:MSigDB MSigDB 2.423E-5 1.298E-3 1.010E-2 3.246E-2 16 483
25 TTTGCAC,MIR-19B:MSigDB TTTGCAC,MIR-19B:MSigDB MSigDB 2.423E-5 1.298E-3 1.010E-2 3.246E-2 16 483
26 hsa-miR-603:PITA hsa-miR-603:PITA TOP PITA 2.891E-5 1.490E-3 1.159E-2 3.874E-2 14 385
27 hsa-miR-498:PITA hsa-miR-498:PITA TOP PITA 4.801E-5 2.383E-3 1.853E-2
6.433E-2
 11 256
28 hsa-miR-590-5p:PITA hsa-miR-590-5p:PITA TOP PITA 5.716E-5 2.647E-3 2.058E-2
7.660E-2
 11 261
29 hsa-miR-892a:PITA hsa-miR-892a:PITA TOP PITA 5.917E-5 2.647E-3 2.058E-2
7.928E-2
 11 262
30 TTTGTAG,MIR-520D:MSigDB TTTGTAG,MIR-520D:MSigDB MSigDB 5.991E-5 2.647E-3 2.058E-2
8.028E-2
 12 310
31 hsa-miR-21:PITA hsa-miR-21:PITA TOP PITA 6.123E-5 2.647E-3 2.058E-2
8.204E-2
 11 263
32 AAGCACA,MIR-218:MSigDB AAGCACA,MIR-218:MSigDB MSigDB 7.928E-5 3.320E-3 2.582E-2
1.062E-1
 13 370
33 hsa-miR-634:PITA hsa-miR-634:PITA TOP PITA 8.272E-5 3.359E-3 2.613E-2
1.108E-1
 11 272
34 hsa-miR-105:PITA hsa-miR-105:PITA TOP PITA 1.021E-4 3.941E-3 3.066E-2
1.368E-1
 14 433
35 hsa-miR-767-5p:PITA hsa-miR-767-5p:PITA TOP PITA 1.036E-4 3.941E-3 3.066E-2
1.389E-1
 11 279
36 hsa-miR-641:PITA hsa-miR-641:PITA TOP PITA 1.059E-4 3.941E-3 3.066E-2
1.419E-1
 15 490
37 hsa-miR-135a:PITA hsa-miR-135a:PITA TOP PITA 1.491E-4 5.256E-3 4.088E-2
1.997E-1
 14 449
38 hsa-miR-135b:PITA hsa-miR-135b:PITA TOP PITA 1.491E-4 5.256E-3 4.088E-2
1.997E-1
 14 449
39 miR-140:PicTar miR-140:PicTar PicTar 1.544E-4 5.306E-3 4.127E-2
2.069E-1
 9 198
40 hsa-miR-220c:PITA hsa-miR-220c:PITA TOP PITA 1.932E-4 6.471E-3
5.033E-2
2.588E-1
 9 204
41 hsa-miR-1208:PITA hsa-miR-1208:PITA TOP PITA 2.191E-4 7.160E-3
5.569E-2
2.936E-1
 11 304
42 ACCAAAG,MIR-9:MSigDB ACCAAAG,MIR-9:MSigDB MSigDB 2.437E-4 7.774E-3
6.046E-2
3.265E-1
 14 471
43 hsa-miR-595:PITA hsa-miR-595:PITA TOP PITA 3.053E-4 9.515E-3
7.401E-2
4.091E-1
 9 217
44 hsa-miR-370:PITA hsa-miR-370:PITA TOP PITA 3.323E-4 9.913E-3
7.710E-2
4.452E-1
 8 174
45 hsa-miR-204:miRTarbase hsa-miR-204:miRTarbase miRTarbase 3.329E-4 9.913E-3
7.710E-2
4.461E-1
 4 34
46 hsa-miR-134:PITA hsa-miR-134:PITA TOP PITA 3.483E-4 1.015E-2
7.891E-2
4.667E-1
 7 133
47 hsa-miR-580:PITA hsa-miR-580:PITA TOP PITA 3.770E-4 1.053E-2
8.193E-2
5.052E-1
 11 324
48 hsa-miR-576-5p:PITA hsa-miR-576-5p:PITA TOP PITA 3.773E-4 1.053E-2
8.193E-2
5.056E-1
 13 434
49 hsa-miR-29c:miRecords TarBase hsa-miR-29c:miRecords TarBase miRecords_TarBase 3.897E-4 1.066E-2
8.289E-2
5.222E-1
 3 15
50 hsa-miR-382:PITA hsa-miR-382:PITA TOP PITA 4.185E-4 1.121E-2
8.723E-2
5.607E-1
 10 276
Show 45 more annotations

17: Drug [Display Chart] 24953 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C488369 dasatinib CTD 2.721E-22 3.901E-18 4.175E-17 6.789E-18 35 472
2 D000069439 Dasatinib CTD 3.127E-22 3.901E-18 4.175E-17 7.802E-18 35 474
3 CID000024766 chondroitin sulfate Stitch 5.358E-21 4.457E-17 4.770E-16 1.337E-16 32 413
4 D015056 1-Methyl-3-isobutylxanthine CTD 1.442E-16 8.896E-13 9.521E-12 3.598E-12 27 391
5 CID000024759 hyaluronan Stitch 1.783E-16 8.896E-13 9.521E-12 4.448E-12 23 263
6 D002857 Chromium CTD 3.560E-15 1.481E-11 1.585E-10 8.884E-11 21 239
7 CID000032756 dermatan sulfate Stitch 8.672E-15 3.091E-11 3.308E-10 2.164E-10 20 220
8 D005944 Glucosamine CTD 4.687E-13 1.303E-9 1.395E-8 1.169E-8 21 306
9 CID000002299 AC1L1DD6 Stitch 4.701E-13 1.303E-9 1.395E-8 1.173E-8 17 179
10 D017258 Medroxyprogesterone Acetate CTD 8.128E-13 2.028E-9 2.171E-8 2.028E-8 23 390
11 CID000037720 pentosan polysulfate Stitch 5.149E-12 1.168E-8 1.250E-7 1.285E-7 12 79
12 C506614 PD 0325901 CTD 1.389E-11 2.888E-8 3.091E-7 3.466E-7 13 108
13 D016559 Tacrolimus CTD 2.452E-11 4.707E-8 5.037E-7 6.119E-7 20 337
14 CID005464587 D3273 Stitch 4.277E-11 7.622E-8 8.157E-7 1.067E-6 12 94
15 CID000104802 Rgd Peptide Stitch 4.933E-11 8.206E-8 8.782E-7 1.231E-6 17 239
16 C113580 U 0126 CTD 2.002E-10 3.123E-7 3.342E-6 4.996E-6 21 422
17 D008769 Methylnitronitrosoguanidine CTD 2.202E-10 3.232E-7 3.459E-6 5.494E-6 17 263
18 C581572 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea CTD 3.516E-10 4.874E-7 5.216E-6 8.772E-6 9 48
19 D003513 Cycloheximide CTD 3.782E-10 4.967E-7 5.316E-6 9.438E-6 21 437
20 7084 UP MS-275; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 1.027E-9 1.281E-6 1.371E-5 2.562E-5 14 183
21 CID000003961 losartan Stitch 1.297E-9 1.541E-6 1.649E-5 3.236E-5 19 378
22 D014747 Vinblastine CTD 1.558E-9 1.701E-6 1.820E-5 3.887E-5 16 260
23 CID006918182 strontium ranelate Stitch 1.568E-9 1.701E-6 1.820E-5 3.912E-5 10 77
24 D013196 Dihydrotestosterone CTD 2.297E-9 2.389E-6 2.556E-5 5.733E-5 18 348
25 C116926 rofecoxib CTD 4.853E-9 4.844E-6 5.184E-5 1.211E-4 11 112
26 C078903 seocalcitol CTD 5.135E-9 4.928E-6 5.274E-5 1.281E-4 13 173
27 C487081 belinostat CTD 6.481E-9 5.990E-6 6.410E-5 1.617E-4 19 417
28 D019808 Losartan CTD 6.826E-9 6.083E-6 6.510E-5 1.703E-4 12 145
29 CID000001647 BAPN Stitch 1.310E-8 1.092E-5 1.169E-4 3.268E-4 9 71
30 5841 UP Podophyllotoxin [518-28-5]; Up 200; 9.6uM; PC3; HT HG-U133A Broad Institute CMAP 1.313E-8 1.092E-5 1.169E-4 3.277E-4 13 187
31 1232 DN troglitazone; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 1.492E-8 1.201E-5 1.285E-4 3.722E-4 13 189
32 CID000005090 rofecoxib Stitch 1.552E-8 1.210E-5 1.295E-4 3.872E-4 11 125
33 D006493 Heparin CTD 1.687E-8 1.242E-5 1.329E-4 4.210E-4 11 126
34 3823 DN CP-690334-01 [459212-38-5]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 1.692E-8 1.242E-5 1.329E-4 4.222E-4 13 191
35 C101814 perfluoro-n-undecanoic acid CTD 2.160E-8 1.540E-5 1.648E-4 5.389E-4 18 402
36 CID005288571 AC1NRBPT Stitch 2.382E-8 1.650E-5 1.766E-4 5.943E-4 12 162
37 3978 UP Dantrolene sodium salt [14663-23-1]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP 2.446E-8 1.650E-5 1.766E-4 6.104E-4 13 197
38 4627 UP Altretamine [654-05-6]; Up 200; 19uM; PC3; HT HG-U133A Broad Institute CMAP 2.598E-8 1.706E-5 1.826E-4 6.483E-4 13 198
39 3822 UP CP-320650-01 [172079-28-6]; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 2.758E-8 1.765E-5 1.889E-4 6.883E-4 13 199
40 C010063 carbonyl sulfide CTD 3.210E-8 2.002E-5 2.143E-4 8.009E-4 11 134
41 CID005289285 Reidispongiolide C Stitch 3.298E-8 2.007E-5 2.148E-4 8.229E-4 15 280
42 CID011957435 azafagomine Stitch 3.782E-8 2.247E-5 2.404E-4 9.436E-4 8 57
43 D014284 Triiodothyronine CTD 4.101E-8 2.380E-5 2.547E-4 1.023E-3 19 468
44 4665 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 4.945E-8 2.805E-5 3.001E-4 1.234E-3 12 173
45 CID000002833 colchine Stitch 6.143E-8 3.406E-5 3.646E-4 1.533E-3 17 383
46 C058705 diethyl malate CTD 6.508E-8 3.530E-5 3.778E-4 1.624E-3 9 85
47 C093973 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one CTD 7.682E-8 4.078E-5 4.365E-4 1.917E-3 17 389
48 CID000005527 Tranilast sodium Stitch 7.961E-8 4.139E-5 4.429E-4 1.987E-3 10 115
49 C007350 nitrofen CTD 8.141E-8 4.146E-5 4.437E-4 2.031E-3 12 181
50 CID000443070 C11104 Stitch 9.786E-8 4.884E-5 5.227E-4 2.442E-3 5 14
Show 45 more annotations

18: Disease [Display Chart] 2418 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0034069 Pulmonary Fibrosis DisGeNET Curated 1.369E-11 3.311E-8 2.770E-7 3.311E-8 22 317
2 umls:C1519670 Tumor Angiogenesis DisGeNET BeFree 7.742E-9 9.360E-6 7.833E-5 1.872E-5 22 443
3 umls:C0153690 Secondary malignant neoplasm of bone DisGeNET BeFree 3.449E-8 2.780E-5 2.326E-4 8.340E-5 17 287
4 umls:C1704272 Benign Prostatic Hyperplasia DisGeNET BeFree 5.837E-8 3.529E-5 2.953E-4 1.411E-4 19 373
5 umls:C0022548 Keloid DisGeNET Curated 4.687E-7 1.766E-4 1.478E-3 1.133E-3 12 166
6 umls:C0162871 Aortic Aneurysm, Abdominal DisGeNET Curated 5.009E-7 1.766E-4 1.478E-3 1.211E-3 11 137
7 umls:C1568363 Tendinosis DisGeNET BeFree 5.113E-7 1.766E-4 1.478E-3 1.236E-3 5 15
8 umls:C0024796 Marfan Syndrome DisGeNET Curated 8.479E-7 2.537E-4 2.123E-3 2.050E-3 7 46
9 umls:C1800706 Idiopathic Pulmonary Fibrosis DisGeNET Curated 9.886E-7 2.537E-4 2.123E-3 2.390E-3 16 323
10 umls:C0017601 Glaucoma DisGeNET Curated 1.049E-6 2.537E-4 2.123E-3 2.537E-3 12 179
11 umls:C1511789 Desmoplastic DisGeNET BeFree 2.233E-6 4.909E-4 4.108E-3 5.400E-3 8 75
12 umls:C0009917 Contracture DisGeNET Curated 3.605E-6 7.103E-4 5.944E-3 8.718E-3 6 37
13 umls:C0740391 Middle Cerebral Artery Occlusion DisGeNET BeFree 3.819E-6 7.103E-4 5.944E-3 9.234E-3 9 107
14 umls:C1658953 tumor vasculature DisGeNET BeFree 4.453E-6 7.691E-4 6.436E-3 1.077E-2 9 109
15 umls:C0003486 Aortic Aneurysm DisGeNET Curated 4.788E-6 7.719E-4 6.459E-3 1.158E-2 12 207
16 umls:C0877015 Pelvic Organ Prolapse DisGeNET Curated 5.318E-6 8.037E-4 6.725E-3 1.286E-2 5 23
17 umls:C0155094 Corneal pannus DisGeNET BeFree 5.785E-6 8.229E-4 6.886E-3 1.399E-2 6 40
18 umls:C0025500 Mesothelioma DisGeNET Curated 7.204E-6 9.677E-4 8.098E-3 1.742E-2 15 334
19 umls:C0007766 Intracranial Aneurysm DisGeNET Curated 8.157E-6 1.038E-3 8.687E-3 1.972E-2 8 89
20 umls:C0024115 Lung diseases DisGeNET Curated 1.236E-5 1.495E-3 1.251E-2 2.989E-2 14 307
21 umls:C0158266 Intervertebral Disc Degeneration DisGeNET Curated 2.594E-5 2.986E-3 2.499E-2
6.271E-2
 7 76
22 umls:C0013720 Ehlers-Danlos Syndrome DisGeNET Curated 2.738E-5 3.010E-3 2.518E-2
6.621E-2
 6 52
23 umls:C0035309 Retinal Diseases DisGeNET Curated 3.270E-5 3.438E-3 2.877E-2
7.908E-2
 13 292
24 umls:C0278488 Carcinoma breast stage IV DisGeNET BeFree 3.954E-5 3.983E-3 3.333E-2
9.560E-2
 14 341
25 umls:C0340643 Dissection of aorta DisGeNET BeFree 4.589E-5 4.353E-3 3.642E-2
1.110E-1
 5 35
26 umls:C0013264 Muscular Dystrophy, Duchenne DisGeNET Curated 4.680E-5 4.353E-3 3.642E-2
1.132E-1
 8 113
27 umls:C1260965 Lipoblastoma DisGeNET Curated 5.004E-5 4.482E-3 3.750E-2
1.210E-1
 3 7
28 umls:C0005940 Bone Diseases DisGeNET Curated 5.503E-5 4.752E-3 3.977E-2
1.331E-1
 9 149
29 umls:C0151744 Myocardial Ischemia DisGeNET Curated 8.429E-5 7.028E-3
5.881E-2
2.038E-1
 15 413
30 umls:C0853879 Invasive breast carcinoma DisGeNET BeFree 9.224E-5 7.434E-3
6.221E-2
2.230E-1
 14 369
31 umls:C0239946 Fibrosis, Liver DisGeNET BeFree 1.037E-4 7.697E-3
6.441E-2
2.506E-1
 13 327
32 umls:C0346957 Disseminated Malignant Neoplasm DisGeNET BeFree 1.050E-4 7.697E-3
6.441E-2
2.538E-1
 9 162
33 umls:C0595936 Aqueous Humor Disorders DisGeNET BeFree 1.070E-4 7.697E-3
6.441E-2
2.588E-1
 6 66
34 umls:C0027092 Myopia DisGeNET Curated 1.130E-4 7.697E-3
6.441E-2
2.733E-1
 8 128
35 umls:C0013336 Dwarfism DisGeNET Curated 1.234E-4 7.697E-3
6.441E-2
2.983E-1
 10 204
36 umls:C1519666 Tumor-Associated Vasculature DisGeNET BeFree 1.264E-4 7.697E-3
6.441E-2
3.056E-1
 5 43
37 umls:C0206638 Giant Cell Tumor of Bone DisGeNET Curated 1.265E-4 7.697E-3
6.441E-2
3.059E-1
 6 68
38 umls:C2676840 LUMBAR DISC HERNIATION, SUSCEPTIBILITY TO DisGeNET Curated 1.305E-4 7.697E-3
6.441E-2
3.156E-1
 2 2
39 umls:C0031111 Periostitis DisGeNET BeFree 1.305E-4 7.697E-3
6.441E-2
3.156E-1
 2 2
40 umls:C0206703 Carcinoma, Giant Cell DisGeNET BeFree 1.305E-4 7.697E-3
6.441E-2
3.156E-1
 2 2
41 umls:C3463916 Complement Factor I (C3 inactivator) deficiency DisGeNET Curated 1.305E-4 7.697E-3
6.441E-2
3.156E-1
 2 2
42 umls:C0018916 Hemangioma DisGeNET Curated 1.609E-4 9.264E-3
7.752E-2
3.891E-1
 6 71
43 umls:C0026850 Muscular Dystrophy DisGeNET Curated 1.967E-4 1.106E-2
9.255E-2
4.755E-1
 10 216
44 umls:C0005967 Bone neoplasms DisGeNET Curated 2.179E-4 1.197E-2
1.002E-1
5.268E-1
 6 75
45 umls:C0011884 Diabetic Retinopathy DisGeNET Curated 2.424E-4 1.279E-2
1.070E-1
5.860E-1
 9 181
46 umls:C0000786 Spontaneous abortion DisGeNET Curated 2.433E-4 1.279E-2
1.070E-1
5.883E-1
 7 108
47 umls:C3539878 Triple Negative Breast Neoplasms DisGeNET BeFree 2.488E-4 1.280E-2
1.071E-1
6.015E-1
 15 456
48 umls:C0023893 Liver Cirrhosis, Experimental DisGeNET Curated 2.724E-4 1.357E-2
1.136E-1
6.586E-1
 7 110
49 umls:C0153381 Malignant neoplasm of mouth DisGeNET BeFree 2.751E-4 1.357E-2
1.136E-1
6.652E-1
 14 410
50 umls:C0022408 Arthropathy DisGeNET Curated 2.879E-4 1.370E-2
1.147E-1
6.962E-1
 7 111
Show 45 more annotations