Toppgene analysis for aggregated_1964_log, IC18, negative side

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1: GO: Molecular Function [Display Chart] 311 annotations before applied cutoff / 18819 genes in category

No results to display

2: GO: Biological Process [Display Chart] 2422 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0019322 pentose biosynthetic process 2.747E-7 6.652E-4 5.568E-3 6.652E-4 3 4
2 GO:0008202 steroid metabolic process 7.203E-7 8.723E-4 7.301E-3 1.745E-3 10 316
3 GO:0008203 cholesterol metabolic process 1.463E-6 1.130E-3 9.461E-3 3.543E-3 7 135
4 GO:1902652 secondary alcohol metabolic process 1.867E-6 1.130E-3 9.461E-3 4.522E-3 7 140
5 GO:0016125 sterol metabolic process 2.705E-6 1.294E-3 1.083E-2 6.552E-3 7 148
6 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 3.206E-6 1.294E-3 1.083E-2 7.764E-3 5 55
7 GO:0085029 extracellular matrix assembly 5.220E-6 1.806E-3 1.512E-2 1.264E-2 4 28
8 GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 1.027E-5 3.109E-3 2.602E-2 2.487E-2 4 33
9 GO:0045940 positive regulation of steroid metabolic process 1.160E-5 3.122E-3 2.613E-2 2.810E-2 4 34
10 GO:0019321 pentose metabolic process 1.912E-5 4.630E-3 3.875E-2 4.630E-2 3 13
11 GO:1903034 regulation of response to wounding 2.674E-5 5.887E-3 4.927E-2
6.476E-2
 10 476
12 GO:0001990 regulation of systemic arterial blood pressure by hormone 3.931E-5 7.709E-3
6.452E-2
9.522E-2
 4 46
13 GO:0019218 regulation of steroid metabolic process 4.933E-5 7.709E-3
6.452E-2
1.195E-1
 5 96
14 GO:0046890 regulation of lipid biosynthetic process 5.018E-5 7.709E-3
6.452E-2
1.215E-1
 6 158
15 GO:0009051 pentose-phosphate shunt, oxidative branch 5.093E-5 7.709E-3
6.452E-2
1.233E-1
 2 3
16 GO:0010899 regulation of phosphatidylcholine catabolic process 5.093E-5 7.709E-3
6.452E-2
1.233E-1
 2 3
17 GO:0042692 muscle cell differentiation 5.450E-5 7.765E-3
6.499E-2
1.320E-1
 9 415
18 GO:0060037 pharyngeal system development 6.361E-5 8.109E-3
6.787E-2
1.541E-1
 3 19
19 GO:0006098 pentose-phosphate shunt 6.361E-5 8.109E-3
6.787E-2
1.541E-1
 3 19
20 GO:0003073 regulation of systemic arterial blood pressure 7.233E-5 8.759E-3
7.331E-2
1.752E-1
 5 104
21 GO:0006694 steroid biosynthetic process 8.040E-5 9.272E-3
7.761E-2
1.947E-1
 6 172
22 GO:0060541 respiratory system development 9.785E-5 1.037E-2
8.677E-2
2.370E-1
 7 258
23 GO:0030198 extracellular matrix organization 1.093E-4 1.037E-2
8.677E-2
2.647E-1
 8 354
24 GO:0043062 extracellular structure organization 1.115E-4 1.037E-2
8.677E-2
2.700E-1
 8 355
25 GO:0031102 neuron projection regeneration 1.124E-4 1.037E-2
8.677E-2
2.723E-1
 4 60
26 GO:0048679 regulation of axon regeneration 1.149E-4 1.037E-2
8.677E-2
2.782E-1
 3 23
27 GO:0060485 mesenchyme development 1.156E-4 1.037E-2
8.677E-2
2.799E-1
 7 265
28 GO:0019682 glyceraldehyde-3-phosphate metabolic process 1.309E-4 1.089E-2
9.118E-2
3.170E-1
 3 24
29 GO:0010893 positive regulation of steroid biosynthetic process 1.309E-4 1.089E-2
9.118E-2
3.170E-1
 3 24
30 GO:1903036 positive regulation of response to wounding 1.349E-4 1.089E-2
9.118E-2
3.268E-1
 6 189
31 GO:0097150 neuronal stem cell population maintenance 1.483E-4 1.159E-2
9.698E-2
3.592E-1
 3 25
32 GO:0050810 regulation of steroid biosynthetic process 1.729E-4 1.308E-2
1.095E-1
4.187E-1
 4 67
33 GO:0030878 thyroid gland development 1.875E-4 1.336E-2
1.118E-1
4.541E-1
 3 27
34 GO:0070570 regulation of neuron projection regeneration 1.875E-4 1.336E-2
1.118E-1
4.541E-1
 3 27
35 GO:0051156 glucose 6-phosphate metabolic process 2.094E-4 1.408E-2
1.179E-1
5.070E-1
 3 28
36 GO:0035909 aorta morphogenesis 2.094E-4 1.408E-2
1.179E-1
5.070E-1
 3 28
37 GO:0050927 positive regulation of positive chemotaxis 2.328E-4 1.524E-2
1.276E-1
5.639E-1
 3 29
38 GO:0060696 regulation of phospholipid catabolic process 2.526E-4 1.562E-2
1.307E-1
6.117E-1
 2 6
39 GO:0061041 regulation of wound healing 2.553E-4 1.562E-2
1.307E-1
6.184E-1
 5 136
40 GO:0050926 regulation of positive chemotaxis 2.579E-4 1.562E-2
1.307E-1
6.247E-1
 3 30
41 GO:0007565 female pregnancy 2.850E-4 1.684E-2
1.409E-1
6.902E-1
 6 217
42 GO:0048678 response to axon injury 3.108E-4 1.792E-2
1.500E-1
7.527E-1
 4 78
43 GO:0035270 endocrine system development 3.325E-4 1.857E-2
1.554E-1
8.054E-1
 5 144
44 GO:0034638 phosphatidylcholine catabolic process 3.526E-4 1.857E-2
1.554E-1
8.541E-1
 2 7
45 GO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis 3.526E-4 1.857E-2
1.554E-1
8.541E-1
 2 7
46 GO:0048251 elastic fiber assembly 3.526E-4 1.857E-2
1.554E-1
8.541E-1
 2 7
47 GO:0045785 positive regulation of cell adhesion 3.897E-4 2.008E-2
1.681E-1
9.439E-1
 8 427
48 GO:0045834 positive regulation of lipid metabolic process 4.263E-4 2.091E-2
1.750E-1
1.000E0
 5 152
49 GO:0042311 vasodilation 4.316E-4 2.091E-2
1.750E-1
1.000E0
 4 85
50 GO:0046889 positive regulation of lipid biosynthetic process 4.316E-4 2.091E-2
1.750E-1
1.000E0
 4 85
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 167 annotations before applied cutoff / 19172 genes in category

No results to display

4: Human Phenotype [Display Chart] 536 annotations before applied cutoff / 4410 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 2655 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002972 abnormal cardiac muscle contractility 5.695E-8 1.320E-4 1.117E-3 1.512E-4 12 284
2 MP:0004258 abnormal placenta size 1.008E-7 1.320E-4 1.117E-3 2.677E-4 8 101
3 MP:0003921 abnormal heart left ventricle morphology 1.652E-7 1.320E-4 1.117E-3 4.386E-4 12 313
4 MP:0004259 small placenta 1.989E-7 1.320E-4 1.117E-3 5.280E-4 7 74
5 MP:0000278 abnormal myocardial fiber morphology 3.963E-7 2.104E-4 1.780E-3 1.052E-3 10 218
6 MP:0004087 abnormal muscle fiber morphology 6.657E-7 2.887E-4 2.443E-3 1.768E-3 13 427
7 MP:0005140 decreased cardiac muscle contractility 7.612E-7 2.887E-4 2.443E-3 2.021E-3 10 234
8 MP:0012501 abnormal pericardial cavity morphology 1.722E-6 5.715E-4 4.836E-3 4.572E-3 8 146
9 MP:0005620 abnormal muscle contractility 2.147E-6 6.333E-4 5.358E-3 5.699E-3 12 398
10 MP:0004883 abnormal vascular wound healing 2.611E-6 6.871E-4 5.814E-3 6.933E-3 6 69
11 MP:0010630 abnormal cardiac muscle tissue morphology 2.847E-6 6.871E-4 5.814E-3 7.558E-3 11 337
12 MP:0009673 increased birth weight 3.657E-6 8.092E-4 6.847E-3 9.710E-3 3 6
13 MP:0004857 abnormal heart weight 6.342E-6 1.128E-3 9.546E-3 1.684E-2 10 296
14 MP:0006116 calcified aortic valve 6.374E-6 1.128E-3 9.546E-3 1.692E-2 3 7
15 MP:0009702 increased birth body size 6.374E-6 1.128E-3 9.546E-3 1.692E-2 3 7
16 MP:0005329 abnormal myocardium layer morphology 7.990E-6 1.326E-3 1.122E-2 2.121E-2 12 452
17 MP:0003141 cardiac fibrosis 8.901E-6 1.390E-3 1.176E-2 2.363E-2 8 182
18 MP:0010545 abnormal heart layer morphology 9.552E-6 1.409E-3 1.192E-2 2.536E-2 12 460
19 MP:0000738 impaired muscle contractility 1.038E-5 1.450E-3 1.227E-2 2.755E-2 10 313
20 MP:0010901 abnormal pulmonary alveolar parenchyma morphology 1.403E-5 1.862E-3 1.575E-2 3.724E-2 6 92
21 MP:0001625 cardiac hypertrophy 1.838E-5 2.323E-3 1.966E-2 4.879E-2 8 201
22 MP:0000275 heart hyperplasia 2.159E-5 2.605E-3 2.204E-2
5.731E-2
 3 10
23 MP:0002139 abnormal hepatobiliary system physiology 3.128E-5 3.582E-3 3.031E-2
8.306E-2
 11 434
24 MP:0004394 abnormal cochlear inner hair cell number 3.238E-5 3.582E-3 3.031E-2
8.596E-2
 4 32
25 MP:0000830 abnormal diencephalon morphology 3.715E-5 3.945E-3 3.338E-2
9.863E-2
 9 289
26 MP:0009672 abnormal birth weight 6.345E-5 6.480E-3
5.483E-2
1.685E-1
 6 120
27 MP:0005085 abnormal gallbladder physiology 7.186E-5 7.066E-3
5.979E-2
1.908E-1
 4 39
28 MP:0010942 abnormal respiratory epithelium morphology 8.464E-5 7.618E-3
6.446E-2
2.247E-1
 8 249
29 MP:0000952 abnormal CNS glial cell morphology 8.604E-5 7.618E-3
6.446E-2
2.284E-1
 9 322
30 MP:0001634 internal hemorrhage 9.239E-5 7.618E-3
6.446E-2
2.453E-1
 9 325
31 MP:0002314 abnormal respiratory mechanics 9.445E-5 7.618E-3
6.446E-2
2.508E-1
 5 80
32 MP:0004163 abnormal adenohypophysis morphology 9.445E-5 7.618E-3
6.446E-2
2.508E-1
 5 80
33 MP:0020135 abnormal heart ventricle wall thickness 9.469E-5 7.618E-3
6.446E-2
2.514E-1
 7 187
34 MP:0000288 abnormal pericardium morphology 9.998E-5 7.739E-3
6.548E-2
2.654E-1
 8 255
35 MP:0000249 abnormal blood vessel physiology 1.042E-4 7.739E-3
6.548E-2
2.767E-1
 10 410
36 MP:0003634 abnormal glial cell morphology 1.064E-4 7.739E-3
6.548E-2
2.824E-1
 10 411
37 MP:0005312 pericardial effusion 1.078E-4 7.739E-3
6.548E-2
2.863E-1
 6 132
38 MP:0002981 increased liver weight 1.124E-4 7.856E-3
6.647E-2
2.985E-1
 6 133
39 MP:0004395 increased cochlear inner hair cell number 1.188E-4 8.090E-3
6.846E-2
3.155E-1
 3 17
40 MP:0003121 genetic imprinting 1.269E-4 8.420E-3
7.125E-2
3.368E-1
 4 45
41 MP:0011655 abnormal systemic artery morphology 1.412E-4 8.853E-3
7.491E-2
3.749E-1
 8 268
42 MP:0002706 abnormal kidney size 1.425E-4 8.853E-3
7.491E-2
3.783E-1
 9 344
43 MP:0002707 abnormal kidney weight 1.434E-4 8.853E-3
7.491E-2
3.807E-1
 6 139
44 MP:0005023 abnormal wound healing 1.487E-4 8.970E-3
7.590E-2
3.947E-1
 7 201
45 MP:0006382 abnormal lung epithelium morphology 1.612E-4 9.511E-3
8.048E-2
4.280E-1
 6 142
46 MP:0005232 abnormal mesenteric lymph node morphology 1.773E-4 1.014E-2
8.579E-2
4.708E-1
 4 49
47 MP:0001711 abnormal placenta morphology 1.807E-4 1.014E-2
8.579E-2
4.799E-1
 9 355
48 MP:0000343 altered response to myocardial infarction 1.833E-4 1.014E-2
8.579E-2
4.867E-1
 5 92
49 MP:0006090 abnormal utricle morphology 1.919E-4 1.039E-2
8.789E-2
5.095E-1
 4 50
50 MP:0008466 enlarged mesenteric lymph nodes 1.968E-4 1.039E-2
8.789E-2
5.225E-1
 3 20
Show 45 more annotations

6: Domain [Display Chart] 654 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR003912 Protea act rcpt InterPro 1.074E-4 3.558E-2
2.512E-1
7.027E-2
 2 4
2 IPR009030 Growth fac rcpt InterPro 5.459E-4 3.558E-2
2.512E-1
3.570E-1
 5 156
3 PF15040 Humanin Pfam 7.925E-4 3.558E-2
2.512E-1
5.183E-1
 2 10
4 IPR028139 Humanin InterPro 7.925E-4 3.558E-2
2.512E-1
5.183E-1
 2 10
5 SM00523 DWA SMART 1.156E-3 3.558E-2
2.512E-1
7.560E-1
 2 12
6 IPR003619 MAD homology1 Dwarfin-type InterPro 1.156E-3 3.558E-2
2.512E-1
7.560E-1
 2 12
7 PF03165 MH1 Pfam 1.156E-3 3.558E-2
2.512E-1
7.560E-1
 2 12
8 PS51120 LDLRB PROSITE 1.585E-3 3.558E-2
2.512E-1
1.000E0
 2 14
9 PF00058 Ldl recept b Pfam 1.585E-3 3.558E-2
2.512E-1
1.000E0
 2 14
10 SM00135 LY SMART 1.824E-3 3.558E-2
2.512E-1
1.000E0
 2 15
11 IPR000033 LDLR classB rpt InterPro 1.824E-3 3.558E-2
2.512E-1
1.000E0
 2 15
12 IPR000716 Thyroglobulin 1 InterPro 2.349E-3 3.558E-2
2.512E-1
1.000E0
 2 17
13 PF00086 Thyroglobulin 1 Pfam 2.349E-3 3.558E-2
2.512E-1
1.000E0
 2 17
14 PS00484 THYROGLOBULIN 1 1 PROSITE 2.349E-3 3.558E-2
2.512E-1
1.000E0
 2 17
15 4.10.800.10 - Gene3D 2.349E-3 3.558E-2
2.512E-1
1.000E0
 2 17
16 PS51162 THYROGLOBULIN 1 2 PROSITE 2.349E-3 3.558E-2
2.512E-1
1.000E0
 2 17
17 SM00211 TY SMART 2.349E-3 3.558E-2
2.512E-1
1.000E0
 2 17
18 SM00033 CH SMART 2.707E-3 3.558E-2
2.512E-1
1.000E0
 3 65
19 PF00307 CH Pfam 3.341E-3 3.558E-2
2.512E-1
1.000E0
 3 70
20 1.10.418.10 - Gene3D 3.478E-3 3.558E-2
2.512E-1
1.000E0
 3 71
21 PS50021 CH PROSITE 3.761E-3 3.558E-2
2.512E-1
1.000E0
 3 73
22 PF02893 GRAM Pfam 3.935E-3 3.558E-2
2.512E-1
1.000E0
 2 22
23 IPR004182 GRAM InterPro 3.935E-3 3.558E-2
2.512E-1
1.000E0
 2 22
24 IPR001715 CH-domain InterPro 4.059E-3 3.558E-2
2.512E-1
1.000E0
 3 75
25 IPR007191 Sec8 exocyst InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
26 PF04048 Sec8 exocyst Pfam 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
27 IPR015752 Lep receptor InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
28 IPR012210 IGFBP-2 InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
29 IPR003829 Pirin N dom InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
30 PS00621 TISSUE FACTOR PROSITE 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
31 PS00461 6PGD PROSITE 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
32 IPR016354 Tissue fac/coagulation fac-3 InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
33 PS00884 OSTEOPONTIN PROSITE 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
34 IPR033598 WBP2 InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
35 PS00088 SOD MN PROSITE 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
36 IPR030472 Tissue Factor CS InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
37 IPR006114 6PGDH C InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
38 IPR000935 Thrmbn rcpt InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
39 PF02777 Sod Fe C Pfam 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
40 SM01350 6PGD SMART 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
41 IPR030464 LYST InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
42 IPR003943 Prot act rcpt 3 InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
43 SM00017 OSTEO SMART 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
44 IPR019832 Mn/Fe SOD C InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
45 IPR019841 Osteopontin CS InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
46 IPR013576 IGF2 C InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
47 IPR012284 6PGD dom 3 InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
48 IPR030266 SYNE2 InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
49 PF00865 Osteopontin Pfam 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
50 IPR006113 6PGDH Gnd/GntZ InterPro 4.270E-3 3.558E-2
2.512E-1
1.000E0
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 533 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 198829 Pentose Phosphate Pathway BioSystems: WikiPathways 7.421E-6 1.222E-3 8.377E-3 3.955E-3 3 8
2 142460 pentose phosphate pathway BioSystems: BIOCYC 7.421E-6 1.222E-3 8.377E-3 3.955E-3 3 8
3 106220 Pentose phosphate pathway (hexose monophosphate shunt) BioSystems: REACTOME 7.421E-6 1.222E-3 8.377E-3 3.955E-3 3 8
4 PW:0000102 The extracellular signal-regulated RAF/MEK/ERK signaling Pathway Ontology 9.168E-6 1.222E-3 8.377E-3 4.887E-3 4 26
5 PW:0000238 insulin-like growth factor signaling Pathway Ontology 2.872E-5 2.552E-3 1.750E-2 1.531E-2 3 12
6 413343 Pentose phosphate pathway (Pentose phosphate cycle) BioSystems: KEGG 2.872E-5 2.552E-3 1.750E-2 1.531E-2 3 12
7 PW:0000045 pentose phosphate Pathway Ontology 4.717E-5 3.592E-3 2.463E-2 2.514E-2 3 14
8 142459 pentose phosphate pathway (oxidative branch) BioSystems: BIOCYC 8.010E-5 3.881E-3 2.661E-2 4.269E-2 2 3
9 PW:0000573 pentose phosphate - oxidative phase Pathway Ontology 8.010E-5 3.881E-3 2.661E-2 4.269E-2 2 3
10 161026 Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) BioSystems: REACTOME 8.010E-5 3.881E-3 2.661E-2 4.269E-2 2 3
11 PW:0000518 Atherosclerosis Pathway Ontology 8.010E-5 3.881E-3 2.661E-2 4.269E-2 2 3
12 198871 Id Signaling Pathway BioSystems: WikiPathways 1.501E-4 6.394E-3 4.384E-2
8.000E-2
 4 52
13 413345 Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P BioSystems: KEGG 1.597E-4 6.394E-3 4.384E-2
8.510E-2
 2 4
14 105908 Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) BioSystems: REACTOME 1.680E-4 6.394E-3 4.384E-2
8.952E-2
 3 21
15 82928 Pentose phosphate pathway BioSystems: KEGG 4.031E-4 1.432E-2
9.821E-2
2.149E-1
 3 28
16 P00032 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade PantherDB 4.480E-4 1.492E-2
1.023E-1
2.388E-1
 3 29
17 M4910 ERK1/ERK2 MAPK Pathway MSigDB C2 BIOCARTA (v5.1) 6.013E-4 1.885E-2
1.293E-1
3.205E-1
 3 32
18 198879 Delta-Notch Signaling Pathway BioSystems: WikiPathways 9.879E-4 2.925E-2
2.006E-1
5.266E-1
 4 85
Show 13 more annotations

8: Pubmed [Display Chart] 20696 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19625176 PTEN identified as important risk factor of chronic obstructive pulmonary disease. Pubmed 9.264E-9 3.746E-5 3.939E-4 1.917E-4 9 376
2 19625176:gr PTEN identified as important risk factor of chronic obstructive pulmonary disease. GeneRIF 9.264E-9 3.746E-5 3.939E-4 1.917E-4 9 376
3 18676680 Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. Pubmed 1.038E-8 3.746E-5 3.939E-4 2.148E-4 9 381
4 18676680:gr Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. GeneRIF 1.038E-8 3.746E-5 3.939E-4 2.148E-4 9 381
5 19170196:gr Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. GeneRIF 1.086E-8 3.746E-5 3.939E-4 2.247E-4 9 383
6 19170196 Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. Pubmed 1.086E-8 3.746E-5 3.939E-4 2.247E-4 9 383
7 19692168 Genetic susceptibility to distinct bladder cancer subphenotypes. Pubmed 2.495E-8 6.456E-5 6.788E-4 5.165E-4 9 422
8 19692168:gr Genetic susceptibility to distinct bladder cancer subphenotypes. GeneRIF 2.495E-8 6.456E-5 6.788E-4 5.165E-4 9 422
9 26976474 Correlation Between IGFs-Related Proteins Expression and Incidence of Colorectal Cancer in Diabetic Patients and Related Mechanisms. Pubmed 3.803E-8 8.745E-5 9.195E-4 7.870E-4 3 5
10 25241761 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. Pubmed 1.432E-7 2.683E-4 2.821E-3 2.963E-3 8 371
11 18660489:gr Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. GeneRIF 1.556E-7 2.683E-4 2.821E-3 3.220E-3 7 250
12 18660489 Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. Pubmed 1.556E-7 2.683E-4 2.821E-3 3.220E-3 7 250
13 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 1.823E-7 2.695E-4 2.834E-3 3.773E-3 8 383
14 19453261:gr High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. GeneRIF 1.823E-7 2.695E-4 2.834E-3 3.773E-3 8 383
15 19962924:gr Mature IGF-II prevents the formation of "big" IGF-II/IGFBP-2 complex in the human circulation. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
16 17376866 Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
17 18537183 Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
18 20442298:gr Thrombin regulates the metastatic potential of human rhabdomyosarcoma cells: distinct role of PAR1 and PAR3 signaling. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
19 11816709:gr Role of protease-activated receptor 1 in tumor metastasis promoted by tissue factor. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
20 23485169 Do matrix metalloproteinase-1 and glucose-6-phosphate dehydrogenase gene polymorphisms interact in promoting lymphoma development? Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
21 21835828 Correlation between MMP1-PAR1 axis and clinical outcome of primary gallbladder carcinoma. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
22 21866461 [Inhibitory effect and mechanism of (-)-epigallocatechin-3-gallate on HT29 and HCT-8 colorectal cancer cell lines and expression of HES1 and JAG1]. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
23 22042095:gr The distribution of IGF2 and IMP3 in osteosarcoma and its relationship with angiogenesis. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
24 18618724:gr KOC (K homology domain containing protein overexpressed in cancer) and S100A4-protein immunoreactivity improves the diagnostic sensitivity of biliary brushing cytology for diagnosing pancreaticobiliary malignancies. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
25 17640993:gr Rho guanosine 5'-triphosphatases differentially regulate insulin-like growth factor I (IGF-I) receptor-dependent and -independent actions of IGF-II on human trophoblast migration. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
26 19713175 Levels of insulin-like growth factors and their receptors in placenta in relation to macrosomia. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
27 15355996:gr Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
28 19276395:gr Insulin-like growth factors and insulin-like growth factor-binding proteins in relation to disease status and incidence of hypoglycaemia in patients with a gastrointestinal stromal tumour. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
29 12727212 In vivo processed fragments of IGF binding protein-2 copurified with bioactive IGF-II. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
30 21866461:gr [Inhibitory effect and mechanism of (-)-epigallocatechin-3-gallate on HT29 and HCT-8 colorectal cancer cell lines and expression of HES1 and JAG1]. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
31 16489073:gr Association of S100A4 and osteopontin with specific prognostic factors and survival of patients with minimally invasive breast cancer. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
32 15256362:gr Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
33 22042095 The distribution of IGF2 and IMP3 in osteosarcoma and its relationship with angiogenesis. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
34 17376866:gr Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
35 18524796 Elevated serum levels of IGF-binding protein 2 in patients with non-seminomatous germ cell cancer: correlation with tumor markers alpha-fetoprotein and human chorionic gonadotropin. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
36 22188815 Potent inhibition of angiogenesis by the IGF-1 receptor-targeting antibody SCH717454 is reversed by IGF-2. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
37 21613208:gr Insulin growth factor-2 binding protein 3 (IGF2BP3) is a glioblastoma-specific marker that activates phosphatidylinositol 3-kinase/mitogen-activated protein kinase (PI3K/MAPK) pathways by modulating IGF-2. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
38 21909684:gr Prognostic value of matrix metalloproteinase-1/ proteinase-activated receptor-1 signaling axis in hepatocellular carcinoma. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
39 17786320 Upregulation of IGF-2 and IGF-1 receptor expression in oral cancer cell lines. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
40 22407318:gr Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
41 18524796:gr Elevated serum levels of IGF-binding protein 2 in patients with non-seminomatous germ cell cancer: correlation with tumor markers alpha-fetoprotein and human chorionic gonadotropin. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
42 21451543 Global analysis of BRAFV600E target genes in human melanocytes identifies matrix metalloproteinase-1 as a critical mediator of melanoma growth. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
43 17341887:gr Insulin-like growth factors and binding proteins in early milk from mothers of preterm and term infants. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
44 11816709 Role of protease-activated receptor 1 in tumor metastasis promoted by tissue factor. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
45 19379698 Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
46 8781553 Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
47 9972281 Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
48 17341887 Insulin-like growth factors and binding proteins in early milk from mothers of preterm and term infants. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
49 1714916 Two insulin-like growth factor (IGF)-binding proteins are responsible for the selective affinity for IGF-II of cerebrospinal fluid binding proteins. Pubmed 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
50 21835828:gr Correlation between MMP1-PAR1 axis and clinical outcome of primary gallbladder carcinoma. GeneRIF 2.470E-6 6.472E-4 6.805E-3
5.113E-2
 2 2
Show 45 more annotations

9: Interaction [Display Chart] 1889 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:FHL1 FHL1 interactions 1.633E-5 3.086E-2
2.506E-1
 3.086E-2 4 34

10: Cytoband [Display Chart] 75 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7p15.1 7p15.1 4.240E-4 3.180E-2
1.559E-1
 3.180E-2 2 13
2 5q13 5q13 1.238E-3 3.549E-2
1.739E-1
9.289E-2
 2 22
3 7q31 7q31 1.867E-3 3.549E-2
1.739E-1
1.401E-1
 2 27
4 1q42.1-q42.2 1q42.1-q42.2 2.366E-3 3.549E-2
1.739E-1
1.774E-1
 1 1
5 12p13-p12.3 12p13-p12.3 2.366E-3 3.549E-2
1.739E-1
1.774E-1
 1 1
6 15q22.33 15q22.33 4.726E-3 3.843E-2
1.884E-1
3.545E-1
 1 2
7 20p12.1-p11.23 20p12.1-p11.23 4.726E-3 3.843E-2
1.884E-1
3.545E-1
 1 2
8 1q21-q25 1q21-q25 4.726E-3 3.843E-2
1.884E-1
3.545E-1
 1 2
9 9q22.1-q22.2 9q22.1-q22.2 4.726E-3 3.843E-2
1.884E-1
3.545E-1
 1 2
10 11q22.3 11q22.3 5.124E-3 3.843E-2
1.884E-1
3.843E-1
 2 45
11 1p31.3-p31.2 1p31.3-p31.2 7.081E-3 4.425E-2
2.169E-1
5.311E-1
 1 3
12 7p11 7p11 7.081E-3 4.425E-2
2.169E-1
5.311E-1
 1 3
13 9q34.11 9q34.11 8.668E-3 4.715E-2
2.311E-1
6.501E-1
 2 59
14 3q28-q29 3q28-q29 9.430E-3 4.715E-2
2.311E-1
7.072E-1
 1 4
15 8p22-p21.3 8p22-p21.3 9.430E-3 4.715E-2
2.311E-1
7.072E-1
 1 4
16 1p22-p21 1p22-p21 1.177E-2 4.906E-2
2.404E-1
8.830E-1
 1 5
17 2q35-q36 2q35-q36 1.177E-2 4.906E-2
2.404E-1
8.830E-1
 1 5
18 6q24-q25 6q24-q25 1.177E-2 4.906E-2
2.404E-1
8.830E-1
 1 5
Show 13 more annotations

11: Transcription Factor Binding Site [Display Chart] 433 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$PBX1 02 V$PBX1 02 3.466E-5 1.501E-2
9.978E-2
 1.501E-2 6 109

12: Gene Family [Display Chart] 58 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 219 F2R receptors genenames.org 6.390E-5 3.706E-3 1.722E-2 3.706E-3 2 4
2 1146 GRAM domain containing genenames.org 8.149E-4 2.363E-2
1.098E-1
 4.727E-2 2 13
3 405 Apolipoproteins genenames.org 2.157E-3 4.170E-2
1.938E-1
1.251E-1
 2 21

13: Coexpression [Display Chart] 4966 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M15981 Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.128E-9 3.043E-5 2.766E-4 3.043E-5 13 430
2 M15491 Genes down-regulated in MDA-MB-231 cells (breast cancer) after knockdown of SATB1 [GeneID=6304] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.039E-8 1.364E-4 1.239E-3 3.992E-4 12 442
3 M3645 Genes up-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.239E-8 1.364E-4 1.239E-3 4.091E-4 12 443
4 M1278 Genes down-regulated in pulpal tissue extracted from carious teeth. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.002E-7 3.670E-4 3.335E-3 1.491E-3 9 244
5 M1784 Genes changed in U373-MG cells (malignant glioma) upon treatment with arsenic trioxide [PubChem=14888], a chemical that can cause autophagic cell death. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.695E-7 3.670E-4 3.335E-3 1.835E-3 7 123
6 M2848 Genes down-regulated in MOLM-14 cells (AML) with knockdown of HOXA9 [Gene ID=3205] gene by RNAi vs controls. MSigDB C6: Oncogenic Signatures (v5.1) 5.906E-7 4.889E-4 4.443E-3 2.933E-3 8 193
7 M3450 Genes down-regulated in comparison of intrathymic T progenitor cells (ITTP) versus thymic stromal cells. MSigDB C7: Immunologic Signatures (v5.1) 7.733E-7 5.486E-4 4.985E-3 3.840E-3 8 200
8 M9806 Down-regulated at 8 h following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v5.1) 1.536E-6 9.536E-4 8.666E-3 7.629E-3 5 53
9 M2029 Genes down-regulated in NCI-H1299 cells (large cell neuroendocrine carcinoma) stably expressing SEMA3B [GeneID=7869]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.762E-6 1.524E-3 1.385E-2 1.372E-2 10 410
10 M8831 Genes up-regulated in A549 cells (lung cancer) expressing MIRLET7A3 [GeneID=406883] microRNA off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.556E-6 1.600E-3 1.454E-2 1.766E-2 6 111
11 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.799E-6 1.600E-3 1.454E-2 1.886E-2 10 425
12 M3034 Genes down-regulated in NIH3T3 cells (fibroblasts) transformed by expression of contitutively active (Q63L) form of RHOA [GeneID=387] off plasmid vector; their expression reverted completely after treatment with Y27632 [PubChem=123862], an inhibitor of ROCK proteins. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.867E-6 1.600E-3 1.454E-2 1.920E-2 4 29
13 M2504 Genes whose expression changes in Calu-6 cells (lung cancer) by TNF [GeneID=7124] were not affected by p38 inhibitor LY479754. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.339E-6 1.620E-3 1.472E-2 2.155E-2 9 337
14 M2255 Genes commonly up-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313 ,2078]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.302E-6 1.620E-3 1.472E-2 2.633E-2 8 259
15 M2001 Genes associated with migration rate of 40 human bladder cancer cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.481E-6 1.620E-3 1.472E-2 2.722E-2 7 184
16 M14507 Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.789E-6 1.620E-3 1.472E-2 3.371E-2 10 454
17 M2698 Genes up-regulated in NCI-60 panel of cell lines with mutated TP53 [Gene ID=7157]. MSigDB C6: Oncogenic Signatures (v5.1) 7.753E-6 1.620E-3 1.472E-2 3.850E-2 7 194
18 M14127 Genes up-regulated in multiple myeloma (MM) cell lines treated with both decitabine [PubChem=451668] TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.760E-6 1.620E-3 1.472E-2 3.854E-2 10 461
19 M14555 Down-regulated at any timepoint following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v5.1) 8.103E-6 1.620E-3 1.472E-2 4.024E-2 6 128
20 M11954 Genes up-regulated in DU-145 cells (prostate cancer) in the absence and presence of a dominant negative form of AKT1 [GeneID=207] upon exposure to HGF [GeneID=3082] for 48 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.381E-6 1.620E-3 1.472E-2 4.162E-2 4 35
21 GSE30971 CTRL VS LPS STIM MACROPHAGE WBP7 KO 4H DN Genes down-regulated in bone marrow-derived macrophages with MLL4 [GeneID=9757] knockout: control versus treated with LPS for 4h. MSigDB C7: Immunologic Signatures (v5.1) 8.570E-6 1.620E-3 1.472E-2 4.256E-2 7 197
22 GSE28449 WT VS LRF KO GERMINAL CENTER BCELL UP Genes up-regulated in germinal center B lymphocytes: wildtype versus ZBTB7A [GeneID=51341] knockout. MSigDB C7: Immunologic Signatures (v5.1) 8.858E-6 1.620E-3 1.472E-2 4.399E-2 7 198
23 M5184 Genes down-regulated in comparison of dendritic cells (DC) exposed to T. gondii versus macrophages exposed to T. gondii. MSigDB C7: Immunologic Signatures (v5.1) 9.154E-6 1.620E-3 1.472E-2 4.546E-2 7 199
24 GSE41978 ID2 KO VS BIM KO KLRG1 LOW EFFECTOR CD8 TCELL UP Genes up-regulated in KLRG1 low [GeneID=10219] CD8 T effector cells during infection: ID2 [GeneID=10219] knockout versus BCL2L11 [GeneID=10018] knockout. MSigDB C7: Immunologic Signatures (v5.1) 9.154E-6 1.620E-3 1.472E-2 4.546E-2 7 199
25 M4948 Genes up-regulated in comparison of monocytes versus myeloid dendritic cells (mDC). MSigDB C7: Immunologic Signatures (v5.1) 9.458E-6 1.620E-3 1.472E-2 4.697E-2 7 200
26 GSE43863 TFH VS LY6C LOW CXCR5NEG EFFECTOR CD4 TCELL DN Genes down-regulated in CD4 [GeneID=920] SMARTA effector T cells during acute infection of LCMV: follicular helper (Tfh) versus Ly6c low CXCR5- [GeneID=643]. MSigDB C7: Immunologic Signatures (v5.1) 9.458E-6 1.620E-3 1.472E-2 4.697E-2 7 200
27 M5673 Genes up-regulated in comparison of TconvLN versus TregLN (see Fig. 1 in the paper for details). MSigDB C7: Immunologic Signatures (v5.1) 9.458E-6 1.620E-3 1.472E-2 4.697E-2 7 200
28 M5906 Genes defining early response to estrogen. MSigDB H: Hallmark Gene Sets (v5.1) 9.458E-6 1.620E-3 1.472E-2 4.697E-2 7 200
29 M5890 Genes regulated by NF-kB in response to TNF [GeneID=7124]. MSigDB H: Hallmark Gene Sets (v5.1) 9.458E-6 1.620E-3 1.472E-2 4.697E-2 7 200
30 M9814 Genes down-regulated in poorly differentiated thyroid carcinoma (PDTC) compared to anaplastic thyroid carcinoma (ATC). MSigDB C2: CGP Curated Gene Sets (v5.1) 9.868E-6 1.633E-3 1.484E-2 4.900E-2 5 77
31 M16975 Up-regulated genes in peripheral zone of human pancreatic cancer growing in the pancreas of nude mice compared to that of the tumor from the central zone. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.039E-5 1.664E-3 1.512E-2
5.159E-2
 8 284
32 M13522 Common down-regulated transcripts in fibroblasts expressing either XP/CS or TDD mutant forms of ERCC3 [GeneID=2071], after UVC irradiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.164E-5 1.806E-3 1.641E-2
5.779E-2
 10 483
33 M10508 Genes known to be induced by hypoxia MSigDB C2: CGP Curated Gene Sets (v5.1) 1.265E-5 1.903E-3 1.730E-2
6.281E-2
 5 81
34 M7137 Genes most down-regulated in hypoxia tolerant NCI H460 cells (lung cancer). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.594E-5 2.328E-3 2.116E-2
7.915E-2
 4 41
35 M2413 Genes regulated in MCF7 cells (breast cancer) by expression of the truncated (611-CTF) form of ERBB2 [GeneID=2064] at 60 h time point. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.745E-5 2.476E-3 2.250E-2
8.664E-2
 9 401
36 M1666 Strongly down-regulated at 8-96 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.352E-5 3.244E-3 2.948E-2
1.168E-1
 5 92
37 M11619 Genes down-regulated in MDA-MB-231 cells (breast cancer) after knockdown of PRKCA and ETS1 [GeneID=5578;2113] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.648E-5 3.554E-3 3.230E-2
1.315E-1
 3 16
38 M1459 Genes up-regulated in BEC (blood endothelial cells) compared to LEC (lymphatic endothelial cells). MSigDB C2: CGP Curated Gene Sets (v5.1) 3.091E-5 4.039E-3 3.671E-2
1.535E-1
 6 162
39 M3697 Genes down-regulated in constitutively invasive HT-29 5M21 cells (colon cancer) vs those expressing functionally inactive TATI [GeneID=6690]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.207E-5 4.048E-3 3.679E-2
1.593E-1
 3 17
40 M12391 Top 50 genes up-regulated in A549 cells (lung cancer) expressing STAT3 [GeneID=6774] off an adenovirus vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.261E-5 4.048E-3 3.679E-2
1.619E-1
 4 49
41 M12112 Angiogenic markers up-regulated in lymph endothelial cells upon infection with KSHV (Kaposi's sarcoma herpes virus). MSigDB C2: CGP Curated Gene Sets (v5.1) 3.426E-5 4.150E-3 3.771E-2
1.702E-1
 6 165
42 M12636 Genes up-regulated in peripheral blood monocytes by CSF2RB (GM-CSF) and IL4 [GeneID=1437;3565]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.619E-5 4.233E-3 3.847E-2
1.797E-1
 8 338
43 M5644 Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from healthy donors versus PBMC from patients with acute S. aureus infection. MSigDB C7: Immunologic Signatures (v5.1) 3.666E-5 4.233E-3 3.847E-2
1.820E-1
 6 167
44 M10454 Genes up-regulated in pulpal tissue extracted from carious teeth. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.180E-5 4.618E-3 4.197E-2
2.076E-1
 7 252
45 M7363 Genes up-regulated in MCF7 cells (breast cancer) under hypoxia conditions. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.185E-5 4.618E-3 4.197E-2
2.078E-1
 6 171
46 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.093E-5 5.382E-3 4.891E-2
2.529E-1
 7 260
47 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.093E-5 5.382E-3 4.891E-2
2.529E-1
 9 460
48 M11701 Selected genes up-regulated during invasion of lymphatic vessels during metastasis. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.334E-5 5.518E-3
5.015E-2
2.649E-1
 3 20
49 M4306 Genes down-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.445E-5 5.518E-3
5.015E-2
2.704E-1
 9 464
50 M581 Genes up-regulated in MS427 cells (Wilms tumor with normal WT1 [GeneID=7490]) after treatment with 10 microM tretinoin (ATRA) [PubChem=444795] for 24 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.206E-5 6.164E-3
5.602E-2
3.082E-1
 3 21
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2603 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma 500 dev gonad e13.5 F VascAssocMesenchStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.131E-9 5.546E-6 4.682E-5 5.546E-6 13 373
2 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 6.841E-9 8.904E-6 7.517E-5 1.781E-5 14 494
3 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 6.239E-8 5.413E-5 4.570E-4 1.624E-4 13 496
4 gudmap kidney P0 JuxtaGlom Ren1 k3 1000 kidney P0 JuxtaGlom Ren1 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.140E-7 1.393E-4 1.176E-3 5.570E-4 10 293
5 gudmap dev gonad e12.5 F gudmap devVasOvary Flk k1 1000 dev gonad e12.5 F DevVasOvary Flk k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 6.976E-7 3.631E-4 3.066E-3 1.816E-3 8 187
6 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 1.253E-6 5.195E-4 4.385E-3 3.262E-3 11 445
7 GSM777063 500 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.397E-6 5.195E-4 4.385E-3 3.636E-3 11 450
8 gudmap dev gonad e12.5 F VasAssocMesStromOvary Sma 500 dev gonad e12.5 F VasAssocMesStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.613E-6 7.809E-4 6.592E-3 6.800E-3 10 386
9 gudmap dev gonad e11.5 F GonadVasMes Flk k1 1000 dev gonad e11.5 F GonadVasMes Flk k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.700E-6 7.809E-4 6.592E-3 7.028E-3 8 224
10 gudmap dev gonad e11.5 M ReproVasc Flk k2 500 dev gonad e11.5 M ReproVasc Flk k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.144E-6 7.968E-4 6.726E-3 8.185E-3 5 58
11 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 3.367E-6 7.968E-4 6.726E-3 8.765E-3 11 493
12 gudmap dev gonad e11.5 F GonadVasMes Flk 500 dev gonad e11.5 F GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 5.992E-6 1.290E-3 1.089E-2 1.560E-2 10 424
13 gudmap kidney adult JuxtaGlom Ren1 Captopr k4 1000 kidney adult JuxtaGlom Ren1 Captopr k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.502E-6 1.290E-3 1.089E-2 1.693E-2 7 179
14 gudmap dev gonad e11.5 F ReproVasc Flk k4 1000 dev gonad e11.5 F ReproVasc Flk k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 6.938E-6 1.290E-3 1.089E-2 1.806E-2 5 68
15 gudmap kidney single cell e11.5 MetanephMesench Scamp k3 500 kidney single cell e11.5 MetanephMesench StemCellamp k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.596E-6 1.318E-3 1.113E-2 1.977E-2 6 120
16 GSM777059 500 Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 8.122E-6 1.321E-3 1.115E-2 2.114E-2 10 439
17 gudmap developingLowerUrinaryTract e14.5 bladder 200 k5 DevelopingLowerUrinaryTract e14.5 bladder emap-30872 k-means-cluster#5 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.363E-5 2.087E-3 1.762E-2 3.547E-2 5 78
18 gudmap dev gonad e13.5 M SertoliCell Sox9 k4 1000 dev gonad e13.5 M SertoliCell Sox9 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.579E-5 2.203E-3 1.860E-2 4.109E-2 10 474
19 gudmap developingKidney e15.5 S-shaped body 200 k1 DevelopingKidney e15.5 S-shaped body emap-27855 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.608E-5 2.203E-3 1.860E-2 4.186E-2 4 39
20 endothelial SubClass DCN-hi Top 500 All endothelial SubClass DCN-hi Top 500 All Brain Map - Barres 2.289E-5 2.979E-3 2.515E-2
5.958E-2
 10 495
21 gudmap dev gonad e11.5 M ReproVasc Flk k2 1000 dev gonad e11.5 M ReproVasc Flk k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.453E-5 3.040E-3 2.567E-2
6.385E-2
 5 88
22 gudmap dev gonad e12.5 F SupCellPrec Sry k3 1000 dev gonad e12.5 F SupCellPrec Sry k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.591E-5 3.066E-3 2.588E-2
6.744E-2
 5 89
23 gudmap kidney P0 JuxtaGlom Ren1 k4 500 kidney P0 JuxtaGlom Ren1 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.258E-5 3.687E-3 3.113E-2
8.481E-2
 6 155
24 Lungmap Mouse e18.5 Epithelial (GSE52583) SubClass AT1 Top 500 Cluster 0 Mouse Lung E18.5 Epithelial AT1 c0 Lungmap Mouse Single Cell (Lungmap.net) 3.501E-5 3.798E-3 3.206E-2
9.114E-2
 6 157
25 Lungmap Mouse e18.5 Epithelial (GSE52583) SubClass AT1 Top 500 All Mouse Lung E18.5 Epithelial AT1 top 500 Lungmap Mouse Single Cell (Lungmap.net) 3.689E-5 3.841E-3 3.243E-2
9.604E-2
 9 418
26 JC hmvEC 1000 K4 JC hmvEC top-relative-expression-ranked 1000 k-means-cluster#4 PCBC 4.595E-5 4.600E-3 3.883E-2
1.196E-1
 9 430
27 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 1000 k5 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.997E-5 4.817E-3 4.067E-2
1.301E-1
 5 102
28 gudmap kidney single cell e11.5 MetanephMesench Scamp 500 kidney single cell e11.5 MetanephMesench StemCellamp top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.405E-5 4.930E-3 4.161E-2
1.407E-1
 8 339
29 gudmap developingLowerUrinaryTract e14.5 urethra 200 k1 DevelopingLowerUrinaryTract e14.5 urethra emap-30892 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.492E-5 4.930E-3 4.161E-2
1.430E-1
 4 53
30 gudmap kidney single cell e11.5 MetanephMesench Scamp k2 1000 kidney single cell e11.5 MetanephMesench StemCellamp k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.621E-5 5.605E-3 4.732E-2
1.724E-1
 6 176
31 endothelial Top 500 Cluster 4 endothelial Top 500 Cluster 4 Brain Map - Barres 6.809E-5 5.605E-3 4.732E-2
1.772E-1
 7 258
32 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 7.095E-5 5.605E-3 4.732E-2
1.847E-1
 9 455
33 gudmap kidney P0 JuxtaGlom Ren1 500 kidney P0 JuxtaGlom Ren1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.215E-5 5.605E-3 4.732E-2
1.878E-1
 9 456
34 Lungmap Mouse e16.5 Endothelial Top 500 Cluster 3 Mouse Lung E16.5 Endothelial top 500 c3 Lungmap Mouse Single Cell (Lungmap.net) 7.321E-5 5.605E-3 4.732E-2
1.906E-1
 4 57
35 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 7.842E-5 5.832E-3 4.923E-2
2.041E-1
 9 461
36 Lungmap Mouse e16.5 Myofibro SubClass Smooth Muscle-like Myofibroblast Top 500 Cluster 3 Mouse Lung E16.5 Myofibroblast Smooth Muscle-like Myofibroblast c3 Lungmap Mouse Single Cell (Lungmap.net) 9.997E-5 6.978E-3
5.891E-2
2.602E-1
 5 118
37 gudmap kidney adult RenalCapsule k2 1000 kidney adult RenalCapsule k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.013E-4 6.978E-3
5.891E-2
2.637E-1
 8 371
38 gudmap dev gonad e11.5 M GonadVasMes Flk k2 1000 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.019E-4 6.978E-3
5.891E-2
2.652E-1
 4 62
39 ratio ECTO vs SC 500 K2 ratio induced-Ectoderm vs StemCell top-relative-expression-ranked 500 k-means-cluster#2 PCBC 1.263E-4 8.405E-3
7.095E-2
3.288E-1
 5 124
40 GSM538332 500 alpha beta T cells, NKT.44+NK1.1+.Th, aGC CD1d tet CD3e CD44 NK1.1, Thymus, avg-3 Immgen.org, GSE15907 1.308E-4 8.405E-3
7.095E-2
3.404E-1
 8 385
41 26Dp SubClass 26Dp 4 Top 500 All 26Dp SubClass 26Dp 4 Top 500 All Brain Map - Allen iN 1.324E-4 8.405E-3
7.095E-2
3.446E-1
 9 494
42 gudmap dev gonad e12.5 F VasAssMesen MafB 500 dev gonad e12.5 F VasAssMesen MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.404E-4 8.699E-3
7.344E-2
3.654E-1
 8 389
43 Lungmap Mouse p107 AT2 Epithelial (GSE52583) Top 500 Cluster 0 Mouse Lung p107 Epithelial AT2 top 500 c0 Lungmap Mouse Single Cell (Lungmap.net) 1.466E-4 8.876E-3
7.493E-2
3.817E-1
 5 128
44 Lungmap Mouse e16.5 Proliferative fibroblast SubClass Early fibroblastic progenitor Top 500 Cluster 2 Mouse Lung E16.5 Proliferative fibroblast Early fibroblastic progenitor c2 Lungmap Mouse Single Cell (Lungmap.net) 1.574E-4 9.314E-3
7.862E-2
4.098E-1
 3 27
45 gudmap developingLowerUrinaryTract e14.5 bladder 1000 k5 DevelopingLowerUrinaryTract e14.5 bladder emap-30872 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.613E-4 9.332E-3
7.878E-2
4.199E-1
 8 397
46 gudmap developingLowerUrinaryTract e14.5 urogenital sinus 500 k2 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-5517 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.700E-4 9.535E-3
8.049E-2
4.424E-1
 6 209
47 Lungmap Mouse e16.5 Matrix fibroblast Top 500 Cluster 3 Mouse Lung E16.5 Matrix Fibroblast top 500 c3 Lungmap Mouse Single Cell (Lungmap.net) 1.758E-4 9.535E-3
8.049E-2
4.577E-1
 3 28
48 gudmap dev gonad e11.5 F GonadVasMes Flk k3 500 dev gonad e11.5 F GonadVasMes Flk k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.758E-4 9.535E-3
8.049E-2
4.577E-1
 3 28
49 GSM605811 500 gamma delta T cells, Tgd.vg5-.IEL, CD8a+ CD8b- TCRgd+ Vg5- CD44lo, Small Intestine, avg-3 Immgen.org, GSE15907 1.848E-4 9.818E-3
8.288E-2
4.811E-1
 8 405
50 gudmap dev gonad e11.5 F ReproVasc Flk k1 500 dev gonad e11.5 F ReproVasc Flk k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.956E-4 1.018E-2
8.595E-2
5.091E-1
 3 29
Show 45 more annotations

15: Computational [Display Chart] 291 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 6.652E-7 1.094E-4 6.837E-4 1.936E-4 13 378
2 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 1.094E-6 1.094E-4 6.837E-4 3.184E-4 13 395
3 module 129 Genes in module 129 MSigDb: C4 - CM: Cancer Modules 1.127E-6 1.094E-4 6.837E-4 3.281E-4 10 217
4 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 1.256E-5 9.140E-4 5.715E-3 3.656E-3 12 419
5 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 7.649E-5 4.452E-3 2.783E-2 2.226E-2 10 351
6 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 9.668E-5 4.689E-3 2.932E-2 2.813E-2 10 361
7 module 38 Genes in module 38 MSigDb: C4 - CM: Cancer Modules 1.409E-4 5.857E-3 3.662E-2 4.100E-2 11 455
8 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 3.515E-4 1.279E-2
7.995E-2
1.023E-1
 10 423
9 module 3 Genes in module 3 MSigDb: C4 - CM: Cancer Modules 6.417E-4 2.075E-2
1.297E-1
1.867E-1
 9 375
10 module 6 Genes in module 6 MSigDb: C4 - CM: Cancer Modules 1.149E-3 3.134E-2
1.960E-1
3.344E-1
 9 407
11 module 220 Genes in module 220 MSigDb: C4 - CM: Cancer Modules 1.185E-3 3.134E-2
1.960E-1
3.448E-1
 8 328
Show 6 more annotations

16: MicroRNA [Display Chart] 1014 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-524:miRTarbase hsa-miR-524:miRTarbase miRTarbase 1.605E-5 1.627E-2
1.221E-1
 1.627E-2 2 2
2 hsa-miR-145:PITA hsa-miR-145:PITA TOP PITA 3.357E-5 1.702E-2
1.277E-1
 3.404E-2 9 401
3 ACATTCC,MIR-206:MSigDB ACATTCC,MIR-206:MSigDB MSigDB 1.455E-4 3.690E-2
2.767E-1
1.476E-1
 7 283
4 ACATTCC,MIR-1:MSigDB ACATTCC,MIR-1:MSigDB MSigDB 1.455E-4 3.690E-2
2.767E-1
1.476E-1
 7 283

17: Drug [Display Chart] 17735 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 5298 UP Phenylpropanolamine hydrochloride [154-41-6]; Up 200; 21.4uM; MCF7; HT HG-U133A Broad Institute CMAP 2.604E-9 4.618E-5 4.784E-4 4.618E-5 10 196
2 CID000000449 m vs Stitch 2.847E-7 1.348E-3 1.396E-2 5.050E-3 9 245
3 D008942 Mitoxantrone CTD 3.049E-7 1.348E-3 1.396E-2 5.408E-3 9 247
4 7198 UP Podophyllotoxin [518-28-5]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP 3.645E-7 1.348E-3 1.396E-2 6.464E-3 8 183
5 6919 UP scriptaid; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 3.800E-7 1.348E-3 1.396E-2 6.738E-3 8 184
6 D013196 Dihydrotestosterone CTD 5.748E-7 1.526E-3 1.582E-2 1.019E-2 10 348
7 3313 DN Metixene hydrochloride [1553-34-0]; Down 200; 11.6uM; MCF7; HT HG-U133A Broad Institute CMAP 6.628E-7 1.526E-3 1.582E-2 1.176E-2 8 198
8 4974 DN Arcaine sulfate [14923-17-2]; Down 200; 14.8uM; MCF7; HT HG-U133A Broad Institute CMAP 6.886E-7 1.526E-3 1.582E-2 1.221E-2 8 199
9 D002118 Calcium CTD 1.483E-6 2.923E-3 3.029E-2 2.631E-2 11 483
10 1220 UP SAHA; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 2.029E-6 2.991E-3 3.099E-2 3.599E-2 7 160
11 4985 UP Lasalocid sodium salt [25999-20-6]; Up 200; 6.6uM; MCF7; HT HG-U133A Broad Institute CMAP 2.392E-6 2.991E-3 3.099E-2 4.242E-2 7 164
12 D016685 Mitomycin CTD 2.410E-6 2.991E-3 3.099E-2 4.275E-2 10 408
13 CID010125830 A-432411 Stitch 2.622E-6 2.991E-3 3.099E-2 4.650E-2 3 8
14 CID000022933 PGDN Stitch 2.622E-6 2.991E-3 3.099E-2 4.650E-2 3 8
15 D008770 Methylnitrosourea CTD 2.684E-6 2.991E-3 3.099E-2 4.759E-2 9 321
16 C012606 4-vinyl-1-cyclohexene dioxide CTD 2.807E-6 2.991E-3 3.099E-2 4.978E-2 7 168
17 D018021 Lithium Chloride CTD 2.969E-6 2.991E-3 3.099E-2
5.265E-2
 9 325
18 1656 UP 15d-PGJ2; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 3.036E-6 2.991E-3 3.099E-2
5.384E-2
 7 170
19 CID000211218 40-a Stitch 4.269E-6 3.787E-3 3.923E-2
7.571E-2
 4 30
20 5336 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 4.270E-6 3.787E-3 3.923E-2
7.573E-2
 7 179
21 6971 UP retinoic acid; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP 5.306E-6 4.211E-3 4.362E-2
9.410E-2
 7 185
22 CID000002250 AC1L1D9C Stitch 5.417E-6 4.211E-3 4.362E-2
9.607E-2
 9 350
23 CID000220862 NSC4322 Stitch 5.461E-6 4.211E-3 4.362E-2
9.685E-2
 5 69
24 1480 UP Idoxuridine [54-42-2]; Up 200; 11.2uM; MCF7; HT HG-U133A Broad Institute CMAP 7.004E-6 4.922E-3
5.099E-2
1.242E-1
 7 193
25 D003622 Dapsone CTD 7.144E-6 4.922E-3
5.099E-2
1.267E-1
 4 34
26 1060 UP 2-propylpentanoic acid; Up 200; 50uM; MCF7; HT HG-U133A EA Broad Institute CMAP 7.245E-6 4.922E-3
5.099E-2
1.285E-1
 7 194
27 4393 DN Pancuronium bromide [15500-66-0]; Down 200; 5.4uM; MCF7; HT HG-U133A Broad Institute CMAP 7.493E-6 4.922E-3
5.099E-2
1.329E-1
 7 195
28 7319 DN Pentoxifylline [6493-05-6]; Down 200; 14.4uM; PC3; HT HG-U133A Broad Institute CMAP 8.279E-6 5.063E-3
5.245E-2
1.468E-1
 7 198
29 3439 UP Merbromin [129-16-8]; Up 200; 5uM; MCF7; HT HG-U133A Broad Institute CMAP 8.279E-6 5.063E-3
5.245E-2
1.468E-1
 7 198
30 C070081 fulvestrant CTD 8.865E-6 5.240E-3
5.429E-2
1.572E-1
 10 473
31 CID000031154 S 105 Stitch 1.019E-5 5.831E-3
6.041E-2
1.808E-1
 3 12
32 CID000002676 AC1L1E7N Stitch 1.127E-5 6.247E-3
6.473E-2
1.999E-1
 6 137
33 CID000119561 ampicillin-sulbactam Stitch 1.321E-5 6.538E-3
6.773E-2
2.344E-1
 3 13
34 D010455 Peptides CTD 1.321E-5 6.538E-3
6.773E-2
2.344E-1
 3 13
35 CID000075530 N-ethyl-2-naphthylamine Stitch 1.327E-5 6.538E-3
6.773E-2
2.354E-1
 2 2
36 D008773 Methylphenazonium Methosulfate CTD 1.327E-5 6.538E-3
6.773E-2
2.354E-1
 2 2
37 D019344 Lactic Acid CTD 1.530E-5 7.270E-3
7.533E-2
2.713E-1
 4 41
38 CID000002891 CAS 68-19-9 Stitch 1.558E-5 7.270E-3
7.533E-2
2.763E-1
 6 145
39 C459179 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide CTD 1.684E-5 7.657E-3
7.933E-2
2.986E-1
 6 147
40 C014476 diethyl maleate CTD 1.899E-5 8.420E-3
8.724E-2
3.368E-1
 8 312
41 CID000002622 AC1L1E3B Stitch 2.034E-5 8.588E-3
8.898E-2
3.607E-1
 4 44
42 MESH:D001943/D007213-T Breast Neoplasms affected by Indomethacin CTD Therapeutic 2.034E-5 8.588E-3
8.898E-2
3.607E-1
 4 44
43 D008078 Cholesterol, LDL CTD 2.567E-5 1.059E-2
1.097E-1
4.553E-1
 3 16
44 C093642 SB 203580 CTD 2.775E-5 1.088E-2
1.127E-1
4.921E-1
 8 329
45 CID000104802 Rgd Peptide Stitch 2.793E-5 1.088E-2
1.127E-1
4.953E-1
 7 239
46 CID000005637 U0126 Stitch 2.833E-5 1.088E-2
1.127E-1
5.025E-1
 9 431
47 CID000001719 APMSF Stitch 2.883E-5 1.088E-2
1.127E-1
5.113E-1
 4 48
48 6190 UP 15d-PGJ2; Up 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP 3.124E-5 1.153E-2
1.194E-1
5.541E-1
 6 164
49 3443 UP Monensin sodium salt [22373-78-0]; Up 200; 5.8uM; MCF7; HT HG-U133A Broad Institute CMAP 3.576E-5 1.153E-2
1.194E-1
6.343E-1
 6 168
50 D013866 Thioguanine CTD 3.672E-5 1.153E-2
1.194E-1
6.512E-1
 4 51
Show 45 more annotations

18: Disease [Display Chart] 2048 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0035412 Rhabdomyosarcoma DisGeNET Curated 4.078E-9 8.351E-6 6.850E-5 8.351E-6 13 360
2 umls:C0025286 Meningioma DisGeNET Curated 8.210E-8 8.407E-5 6.895E-4 1.681E-4 12 383
3 umls:C0153381 Malignant neoplasm of mouth DisGeNET BeFree 1.717E-7 1.111E-4 9.111E-4 3.517E-4 12 410
4 umls:C0220641 Lip and Oral Cavity Carcinoma DisGeNET BeFree 2.170E-7 1.111E-4 9.111E-4 4.443E-4 12 419
5 umls:C0029456 Osteoporosis DisGeNET Curated 7.257E-7 2.973E-4 2.438E-3 1.486E-3 10 305
6 umls:C0239946 Fibrosis, Liver DisGeNET BeFree 1.365E-6 3.997E-4 3.279E-3 2.795E-3 10 327
7 umls:C1319315 Adenocarcinoma of large intestine DisGeNET BeFree 1.366E-6 3.997E-4 3.279E-3 2.798E-3 8 186
8 umls:C0021051 Immunologic Deficiency Syndromes DisGeNET Curated 1.841E-6 4.713E-4 3.866E-3 3.771E-3 11 422
9 umls:C0022548 Keloid DisGeNET Curated 7.430E-6 1.691E-3 1.387E-2 1.522E-2 7 166
10 umls:C0034069 Pulmonary Fibrosis DisGeNET Curated 8.774E-6 1.797E-3 1.474E-2 1.797E-2 9 317
11 umls:C0042133 Uterine Fibroids DisGeNET Curated 1.045E-5 1.946E-3 1.596E-2 2.141E-2 9 324
12 umls:C0020542 Pulmonary Hypertension DisGeNET Curated 1.216E-5 2.050E-3 1.681E-2 2.490E-2 8 250
13 umls:C0278883 Metastatic melanoma DisGeNET BeFree 1.301E-5 2.050E-3 1.681E-2 2.664E-2 9 333
14 umls:C1621958 Glioblastoma Multiforme DisGeNET BeFree 1.662E-5 2.125E-3 1.743E-2 3.404E-2 10 434
15 umls:C0877009 Muscle fibrosis DisGeNET BeFree 1.668E-5 2.125E-3 1.743E-2 3.417E-2 3 12
16 umls:C0004045 Asphyxia Neonatorum DisGeNET Curated 1.668E-5 2.125E-3 1.743E-2 3.417E-2 3 12
17 umls:C0042373 Vascular Diseases DisGeNET Curated 1.764E-5 2.125E-3 1.743E-2 3.612E-2 9 346
18 umls:C0524910 Hepatitis C, Chronic DisGeNET Curated 2.520E-5 2.734E-3 2.243E-2
5.160E-2
 9 362
19 umls:C1709246 Non-Neoplastic Disorder DisGeNET BeFree 2.788E-5 2.734E-3 2.243E-2
5.711E-2
 10 461
20 umls:C0334579 Anaplastic astrocytoma DisGeNET Curated 2.804E-5 2.734E-3 2.243E-2
5.742E-2
 6 137
21 umls:C0027831 Neurofibromatosis 1 DisGeNET Curated 2.804E-5 2.734E-3 2.243E-2
5.742E-2
 6 137
22 umls:C0086692 Benign Neoplasm DisGeNET BeFree 3.107E-5 2.892E-3 2.372E-2
6.363E-2
 7 207
23 umls:C0023267 Fibroid Tumor DisGeNET Curated 3.279E-5 2.919E-3 2.395E-2
6.715E-2
 8 287
24 umls:C0042345 Varicosity DisGeNET Curated 3.515E-5 3.000E-3 2.460E-2
7.199E-2
 4 43
25 umls:C0206686 Adrenocortical carcinoma DisGeNET Curated 4.168E-5 3.306E-3 2.712E-2
8.536E-2
 6 147
26 umls:C1762616 Meningioma, benign, no ICD-O subtype DisGeNET BeFree 4.197E-5 3.306E-3 2.712E-2
8.596E-2
 7 217
27 umls:C0410158 Muscle damage DisGeNET BeFree 4.603E-5 3.445E-3 2.826E-2
9.427E-2
 4 46
28 umls:C0751690 Malignant Peripheral Nerve Sheath Tumor DisGeNET BeFree 4.844E-5 3.445E-3 2.826E-2
9.920E-2
 6 151
29 umls:C0030297 Pancreatic Neoplasm DisGeNET Curated 4.879E-5 3.445E-3 2.826E-2
9.992E-2
 9 394
30 umls:C0024117 Chronic Obstructive Airway Disease DisGeNET Curated 5.266E-5 3.595E-3 2.949E-2
1.079E-1
 10 497
31 umls:C1800706 Idiopathic Pulmonary Fibrosis DisGeNET Curated 7.542E-5 4.982E-3 4.087E-2
1.545E-1
 8 323
32 umls:C0338106 Adenocarcinoma of colon DisGeNET Curated 7.929E-5 5.074E-3 4.162E-2
1.624E-1
 7 240
33 umls:C0032927 Precancerous Conditions DisGeNET Curated 8.423E-5 5.106E-3 4.188E-2
1.725E-1
 9 423
34 umls:C0339573 Glaucoma, Primary Open Angle DisGeNET Curated 8.477E-5 5.106E-3 4.188E-2
1.736E-1
 6 167
35 umls:C0033975 Psychotic Disorders DisGeNET Curated 9.254E-5 5.415E-3 4.441E-2
1.895E-1
 7 246
36 umls:C0019202 Hepatolenticular Degeneration DisGeNET Curated 1.003E-4 5.626E-3 4.615E-2
2.054E-1
 4 56
37 umls:C3272363 Ischemic Cerebrovascular Accident DisGeNET Curated 1.034E-4 5.626E-3 4.615E-2
2.118E-1
 8 338
38 umls:C0014474 Ependymoma DisGeNET Curated 1.044E-4 5.626E-3 4.615E-2
2.138E-1
 5 108
39 umls:C0850639 premalignant lesion DisGeNET BeFree 1.132E-4 5.926E-3 4.861E-2
2.318E-1
 3 22
40 umls:C0015230 Exanthema DisGeNET Curated 1.157E-4 5.926E-3 4.861E-2
2.371E-1
 7 255
41 umls:C0494165 Secondary malignant neoplasm of liver DisGeNET BeFree 1.393E-4 6.882E-3
5.645E-2
2.852E-1
 9 452
42 umls:C0376634 Craniofacial Abnormalities DisGeNET Curated 1.444E-4 6.882E-3
5.645E-2
2.957E-1
 6 184
43 umls:C0860204 Cholestatic liver disease DisGeNET BeFree 1.479E-4 6.882E-3
5.645E-2
3.028E-1
 3 24
44 umls:C0334663 Histiocytic sarcoma DisGeNET BeFree 1.479E-4 6.882E-3
5.645E-2
3.028E-1
 3 24
45 umls:C0032000 Pituitary Adenoma DisGeNET BeFree 1.804E-4 8.212E-3
6.735E-2
3.695E-1
 7 274
46 umls:C1512409 Hepatocarcinogenesis DisGeNET BeFree 1.896E-4 8.216E-3
6.739E-2
3.883E-1
 9 471
47 umls:C0948008 Ischemic stroke DisGeNET Curated 1.925E-4 8.216E-3
6.739E-2
3.942E-1
 8 370
48 umls:C0030193 Pain DisGeNET Curated 1.926E-4 8.216E-3
6.739E-2
3.944E-1
 6 194
49 umls:C1704272 Benign Prostatic Hyperplasia DisGeNET BeFree 2.033E-4 8.498E-3
6.970E-2
4.164E-1
 8 373
50 umls:C1708565 Invasive Skin Melanoma DisGeNET BeFree 2.117E-4 8.671E-3
7.112E-2
4.336E-1
 3 27
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