Toppgene analysis for aggregated_1964_log, IC17, positive side

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1: GO: Molecular Function [Display Chart] 530 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030580 quinone cofactor methyltransferase activity 6.826E-5 1.206E-2
8.261E-2
 3.618E-2 6 81
2 GO:0008169 C-methyltransferase activity 6.826E-5 1.206E-2
8.261E-2
 3.618E-2 6 81
3 GO:0008425 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity 6.826E-5 1.206E-2
8.261E-2
 3.618E-2 6 81
4 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1.686E-4 2.233E-2
1.530E-1
8.934E-2
 8 181
5 GO:0005048 signal sequence binding 4.484E-4 4.457E-2
3.054E-1
2.376E-1
 4 42
6 GO:0008168 methyltransferase activity 5.046E-4 4.457E-2
3.054E-1
2.674E-1
 8 213
7 GO:0016741 transferase activity, transferring one-carbon groups 7.230E-4 4.476E-2
3.067E-1
3.832E-1
 8 225
8 GO:0050661 NADP binding 7.491E-4 4.476E-2
3.067E-1
3.970E-1
 4 48
9 GO:0008174 mRNA methyltransferase activity 7.715E-4 4.476E-2
3.067E-1
4.089E-1
 5 84
10 GO:0000268 peroxisome targeting sequence binding 1.067E-3 4.476E-2
3.067E-1
5.654E-1
 2 6
11 GO:0008171 O-methyltransferase activity 1.221E-3 4.476E-2
3.067E-1
6.473E-1
 5 93
12 GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity 1.231E-3 4.476E-2
3.067E-1
6.524E-1
 3 25
13 GO:0030515 snoRNA binding 1.721E-3 4.476E-2
3.067E-1
9.119E-1
 3 28
14 GO:0004448 isocitrate dehydrogenase activity 1.907E-3 4.476E-2
3.067E-1
1.000E0
 3 29
15 GO:0008173 RNA methyltransferase activity 2.005E-3 4.476E-2
3.067E-1
1.000E0
 5 104
16 GO:0004519 endonuclease activity 3.172E-3 4.476E-2
3.067E-1
1.000E0
 6 167
17 GO:0052735 tRNA (cytosine-3-)-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
18 GO:0043791 dimethylamine methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
19 GO:0016435 rRNA (guanine) methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
20 GO:0043833 methylamine-specific methylcobalamin:coenzyme M methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
21 GO:0051994 P-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
22 GO:0052665 tRNA (uracil-2'-O-)-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
23 GO:0051995 Se-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
24 GO:0070677 rRNA (cytosine-2'-O-)-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
25 GO:0052666 tRNA (cytosine-2'-O-)-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
26 GO:0043851 methanol-specific methylcobalamin:coenzyme M methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
27 GO:0016205 selenocysteine methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
28 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
29 GO:0052624 2-phytyl-1,4-naphthoquinone methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
30 GO:0008988 rRNA (adenine-N6-)-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
31 GO:0043777 cobalt-precorrin-7 C15-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
32 GO:0018707 1-phenanthrol methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
33 GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
34 GO:0052667 phosphomethylethanolamine N-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
35 GO:0034931 1-hydroxypyrene methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
36 GO:0043782 cobalt-precorrin-3 C17-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
37 GO:0034933 1-hydroxy-6-methoxypyrene methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
38 GO:0043852 monomethylamine methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
39 GO:0043827 tRNA (adenine-57, 58-N(1)-) methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
40 GO:0043780 cobalt-precorrin-5B C1-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
41 GO:0043803 hydroxyneurosporene-O-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
42 GO:0043834 trimethylamine methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
43 GO:0043770 demethylmenaquinone methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
44 GO:0034807 4,5-dihydroxybenzo(a)pyrene methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
45 GO:0080012 trihydroxyferuloyl spermidine O-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
46 GO:0019702 protein-arginine N5-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
47 GO:0043776 cobalt-precorrin-6B C5-methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
48 GO:0034541 dimethylarsinite methyltransferase activity 4.714E-3 4.476E-2
3.067E-1
1.000E0
 4 79
49 GO:0016433 rRNA (adenine) methyltransferase activity 4.930E-3 4.476E-2
3.067E-1
1.000E0
 4 80
50 GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity 4.930E-3 4.476E-2
3.067E-1
1.000E0
 4 80
Show 45 more annotations

2: GO: Biological Process [Display Chart] 2093 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0022613 ribonucleoprotein complex biogenesis 2.580E-8 5.399E-5 4.440E-4 5.399E-5 19 468
2 GO:0042254 ribosome biogenesis 1.430E-7 1.496E-4 1.230E-3 2.992E-4 15 322
3 GO:0042274 ribosomal small subunit biogenesis 1.485E-6 1.036E-3 8.521E-3 3.108E-3 7 65
4 GO:0030490 maturation of SSU-rRNA 2.396E-6 1.254E-3 1.031E-2 5.015E-3 6 45
5 GO:1901797 negative regulation of signal transduction by p53 class mediator 5.531E-6 2.315E-3 1.904E-2 1.158E-2 5 30
6 GO:0032543 mitochondrial translation 9.978E-6 3.481E-3 2.863E-2 2.088E-2 8 120
7 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 2.375E-5 7.102E-3
5.840E-2
 4.971E-2 4 20
8 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 8.206E-5 1.804E-2
1.484E-1
1.717E-1
 4 27
9 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 8.206E-5 1.804E-2
1.484E-1
1.717E-1
 4 27
10 GO:0006364 rRNA processing 9.356E-5 1.804E-2
1.484E-1
1.958E-1
 10 260
11 GO:2001021 negative regulation of response to DNA damage stimulus 9.483E-5 1.804E-2
1.484E-1
1.985E-1
 5 53
12 GO:1901796 regulation of signal transduction by p53 class mediator 1.066E-4 1.848E-2
1.520E-1
2.231E-1
 8 167
13 GO:0016072 rRNA metabolic process 1.164E-4 1.848E-2
1.520E-1
2.437E-1
 10 267
14 GO:0071826 ribonucleoprotein complex subunit organization 1.236E-4 1.848E-2
1.520E-1
2.588E-1
 9 218
15 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1.721E-4 2.401E-2
1.975E-1
3.602E-1
 3 13
16 GO:0000959 mitochondrial RNA metabolic process 1.837E-4 2.403E-2
1.977E-1
3.845E-1
 4 33
17 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 2.319E-4 2.856E-2
2.348E-1
4.855E-1
 4 35
18 GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage 2.886E-4 3.356E-2
2.760E-1
6.041E-1
 4 37
19 GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.306E-4 3.641E-2
2.995E-1
6.919E-1
 3 16
20 GO:0044743 protein transmembrane import into intracellular organelle 4.308E-4 4.303E-2
3.539E-1
9.017E-1
 4 41
21 GO:0022406 membrane docking 4.318E-4 4.303E-2
3.539E-1
9.037E-1
 5 73
22 GO:0022618 ribonucleoprotein complex assembly 4.736E-4 4.506E-2
3.706E-1
9.913E-1
 8 208
Show 17 more annotations

3: GO: Cellular Component [Display Chart] 286 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005759 mitochondrial matrix 1.488E-7 4.256E-5 2.654E-4 4.256E-5 17 425
2 GO:0031314 extrinsic component of mitochondrial inner membrane 7.057E-5 6.485E-3 4.043E-2 2.018E-2 3 10
3 GO:0005778 peroxisomal membrane 1.369E-4 6.485E-3 4.043E-2 3.916E-2 5 58
4 GO:0031903 microbody membrane 1.369E-4 6.485E-3 4.043E-2 3.916E-2 5 58
5 GO:0044439 peroxisomal part 1.756E-4 6.485E-3 4.043E-2
5.022E-2
 6 96
6 GO:0044438 microbody part 1.756E-4 6.485E-3 4.043E-2
5.022E-2
 6 96
7 GO:0005779 integral component of peroxisomal membrane 2.087E-4 6.485E-3 4.043E-2
5.970E-2
 3 14
8 GO:0031231 intrinsic component of peroxisomal membrane 2.087E-4 6.485E-3 4.043E-2
5.970E-2
 3 14
9 GO:0034455 t-UTP complex 2.170E-4 6.485E-3 4.043E-2
6.205E-2
 2 3
10 GO:0044455 mitochondrial membrane part 2.267E-4 6.485E-3 4.043E-2
6.485E-2
 8 189
11 GO:0044452 nucleolar part 3.330E-4 8.658E-3
5.398E-2
9.524E-2
 5 70
12 GO:0042645 mitochondrial nucleoid 6.367E-4 1.517E-2
9.461E-2
1.821E-1
 4 46
13 GO:0009295 nucleoid 7.492E-4 1.648E-2
1.028E-1
2.143E-1
 4 48
14 GO:0005777 peroxisome 1.405E-3 2.678E-2
1.670E-1
4.017E-1
 6 142
15 GO:0042579 microbody 1.405E-3 2.678E-2
1.670E-1
4.017E-1
 6 142
16 GO:0030688 preribosome, small subunit precursor 1.969E-3 3.519E-2
2.194E-1
5.630E-1
 2 8
17 GO:0031312 extrinsic component of organelle membrane 2.777E-3 4.365E-2
2.722E-1
7.943E-1
 3 33
18 GO:0030990 intraciliary transport particle 2.777E-3 4.365E-2
2.722E-1
7.943E-1
 3 33
19 GO:0070461 SAGA-type complex 3.027E-3 4.365E-2
2.722E-1
8.657E-1
 3 34
20 GO:0030684 preribosome 3.052E-3 4.365E-2
2.722E-1
8.730E-1
 4 70
Show 15 more annotations

4: Human Phenotype [Display Chart] 588 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0003355 Aminoaciduria 3.318E-5 1.951E-2
1.357E-1
 1.951E-2 5 50
2 HP:0001251 Ataxia 9.828E-5 2.699E-2
1.877E-1
5.779E-2
 10 321
3 HP:0000580 Pigmentary retinopathy 1.377E-4 2.699E-2
1.877E-1
8.098E-2
 5 67

5: Mouse Phenotype [Display Chart] 1351 annotations before applied cutoff / 9299 genes in category

No results to display

6: Domain [Display Chart] 830 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3.40.50.150 - Gene3D 8.659E-5 3.209E-2
2.343E-1
7.187E-2
 7 120
2 IPR029063 SAM-dependent MTases InterPro 9.610E-5 3.209E-2
2.343E-1
7.976E-2
 7 122
3 IPR001950 SUI1 InterPro 7.395E-4 3.209E-2
2.343E-1
6.138E-1
 2 5
4 PF04438 zf-HIT Pfam 1.103E-3 3.209E-2
2.343E-1
9.154E-1
 2 6
5 PF08373 RAP Pfam 1.103E-3 3.209E-2
2.343E-1
9.154E-1
 2 6
6 SM00952 RAP SMART 1.103E-3 3.209E-2
2.343E-1
9.154E-1
 2 6
7 PF08368 FAST 2 Pfam 1.103E-3 3.209E-2
2.343E-1
9.154E-1
 2 6
8 PS51083 ZF HIT PROSITE 1.103E-3 3.209E-2
2.343E-1
9.154E-1
 2 6
9 PS51286 RAP PROSITE 1.103E-3 3.209E-2
2.343E-1
9.154E-1
 2 6
10 IPR013584 RAP InterPro 1.103E-3 3.209E-2
2.343E-1
9.154E-1
 2 6
11 PF02824 TGS Pfam 1.103E-3 3.209E-2
2.343E-1
9.154E-1
 2 6
12 IPR010622 FAST Leu-rich InterPro 1.103E-3 3.209E-2
2.343E-1
9.154E-1
 2 6
13 IPR004095 TGS InterPro 1.103E-3 3.209E-2
2.343E-1
9.154E-1
 2 6
14 IPR013579 FAST 2 InterPro 1.103E-3 3.209E-2
2.343E-1
9.154E-1
 2 6
15 PF06743 FAST 1 Pfam 1.103E-3 3.209E-2
2.343E-1
9.154E-1
 2 6
16 IPR007529 Znf HIT InterPro 1.103E-3 3.209E-2
2.343E-1
9.154E-1
 2 6
17 IPR012676 TGS-like InterPro 1.535E-3 3.209E-2
2.343E-1
1.000E0
 2 7
18 PF03129 HGTP anticodon Pfam 2.602E-3 3.209E-2
2.343E-1
1.000E0
 2 9
19 3.40.50.800 - Gene3D 3.930E-3 3.209E-2
2.343E-1
1.000E0
 2 11
20 IPR002314 aa-tRNA-synt IIb InterPro 3.930E-3 3.209E-2
2.343E-1
1.000E0
 2 11
21 PF00587 tRNA-synt 2b Pfam 3.930E-3 3.209E-2
2.343E-1
1.000E0
 2 11
22 IPR002030 Mit uncoupling InterPro 4.689E-3 3.209E-2
2.343E-1
1.000E0
 2 12
23 1.20.1050.10 - Gene3D 4.696E-3 3.209E-2
2.343E-1
1.000E0
 3 39
24 IPR010987 Glutathione-S-Trfase C-like InterPro 4.696E-3 3.209E-2
2.343E-1
1.000E0
 3 39
25 3.10.20.30 - Gene3D 6.392E-3 3.209E-2
2.343E-1
1.000E0
 2 14
26 IPR012675 Beta-grasp dom InterPro 6.392E-3 3.209E-2
2.343E-1
1.000E0
 2 14
27 IPR004154 Anticodon-bd InterPro 6.392E-3 3.209E-2
2.343E-1
1.000E0
 2 14
28 PF02985 HEAT Pfam 8.396E-3 3.209E-2
2.343E-1
1.000E0
 3 48
29 IPR013893 RNase P Rpp40 InterPro 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
30 IPR033452 GH30 C InterPro 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
31 IPR009524 UPF0686 InterPro 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
32 IPR029371 TMEM101 InterPro 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
33 IPR030388 G ERA dom InterPro 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
34 PF12767 SAGA-Tad1 Pfam 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
35 IPR005677 Fum hydII InterPro 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
36 IPR024711 Catalase clade1/3 InterPro 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
37 PF10234 Cluap1 Pfam 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
38 IPR006708 Pex19 InterPro 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
39 PS51402 CATALASE 3 PROSITE 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
40 IPR004887 Glutathione synth subst-bd euk InterPro 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
41 IPR003829 Pirin N dom InterPro 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
42 IPR027735 RP1/EB2 vertebrate InterPro 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
43 IPR033411 Ribonuclease PIN InterPro 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
44 PF01103 Bac surface Ag Pfam 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
45 IPR016443 RNA3' term phos cyc type 2 InterPro 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
46 PF15053 Njmu-R1 Pfam 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
47 PS01184 UBIE 2 PROSITE 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
48 IPR032913 BECN1 InterPro 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
49 IPR002226 Catalase haem BS InterPro 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
50 PF03199 GSH synthase Pfam 8.700E-3 3.209E-2
2.343E-1
1.000E0
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 661 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 131226 Peroxisome BioSystems: KEGG 5.205E-5 3.440E-2
2.433E-1
 3.440E-2 6 80

8: Pubmed [Display Chart] 10083 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 27499296 Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. Pubmed 5.967E-12 6.017E-8 5.894E-7 6.017E-8 15 409
2 24797263 Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. Pubmed 7.196E-10 3.628E-6 3.554E-5 7.256E-6 12 323
3 20186120 A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. Pubmed 1.598E-9 5.370E-6 5.260E-5 1.611E-5 10 207
4 11402059 Multiple distinct targeting signals in integral peroxisomal membrane proteins. Pubmed 3.222E-8 8.122E-5 7.956E-4 3.249E-4 3 3
5 10704444 PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. Pubmed 1.789E-7 3.608E-4 3.534E-3 1.804E-3 4 16
6 11390669 Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences. Pubmed 1.117E-6 1.408E-3 1.379E-2 1.126E-2 3 7
7 17624330 The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11. Pubmed 1.117E-6 1.408E-3 1.379E-2 1.126E-2 3 7
8 17624330:gr The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11. GeneRIF 1.117E-6 1.408E-3 1.379E-2 1.126E-2 3 7
9 25693804 Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. Pubmed 1.423E-6 1.595E-3 1.562E-2 1.435E-2 9 332
10 20531392 The peroxisomal receptor Pex19p forms a helical mPTS recognition domain. Pubmed 1.783E-6 1.798E-3 1.761E-2 1.798E-2 3 8
11 12096124 Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay. Pubmed 2.669E-6 2.446E-3 2.396E-2 2.691E-2 3 9
12 14709540 PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins. Pubmed 3.803E-6 3.196E-3 3.130E-2 3.835E-2 3 10
13 11042152 Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Pubmed 9.329E-6 4.974E-3 4.872E-2
9.406E-2
 8 317
14 15480429 Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer. Pubmed 1.019E-5 4.974E-3 4.872E-2
1.027E-1
 2 2
15 9714768 cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. Pubmed 1.019E-5 4.974E-3 4.872E-2
1.027E-1
 2 2
16 19621595:gr [Expression of gene BRMS1 and CD44v6 protein in supraglottic laryngeal carcinoma and its clinical significance]. GeneRIF 1.019E-5 4.974E-3 4.872E-2
1.027E-1
 2 2
17 24642125 The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling protein-2 by angiopoietin-1. Pubmed 1.019E-5 4.974E-3 4.872E-2
1.027E-1
 2 2
18 19621595 [Expression of gene BRMS1 and CD44v6 protein in supraglottic laryngeal carcinoma and its clinical significance]. Pubmed 1.019E-5 4.974E-3 4.872E-2
1.027E-1
 2 2
19 20171429 [In vitro comparison of the efficacy and photostability of three sunscreen creams]. Pubmed 1.019E-5 4.974E-3 4.872E-2
1.027E-1
 2 2
20 22252321 Sam50 functions in mitochondrial intermembrane space bridging and biogenesis of respiratory complexes. Pubmed 1.019E-5 4.974E-3 4.872E-2
1.027E-1
 2 2
21 10810093 Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Pubmed 1.036E-5 4.974E-3 4.872E-2
1.045E-1
 6 152
22 24056301 The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response. Pubmed 1.425E-5 6.532E-3
6.398E-2
1.437E-1
 3 15
23 12429849 Functional proteomic analysis of human nucleolus. Pubmed 2.471E-5 7.244E-3
7.096E-2
2.491E-1
 5 106
24 24778252 TRIM65 regulates microRNA activity by ubiquitination of TNRC6. Pubmed 2.513E-5 7.244E-3
7.096E-2
2.534E-1
 8 364
25 17018283:gr RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. GeneRIF 3.050E-5 7.244E-3
7.096E-2
3.075E-1
 2 3
26 19478087 Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2). Pubmed 3.050E-5 7.244E-3
7.096E-2
3.075E-1
 2 3
27 9230071 A novel Rab9 effector required for endosome-to-TGN transport. Pubmed 3.050E-5 7.244E-3
7.096E-2
3.075E-1
 2 3
28 16769818 TIP47 is a key effector for Rab9 localization. Pubmed 3.050E-5 7.244E-3
7.096E-2
3.075E-1
 2 3
29 14715663 Potential role for Pex19p in assembly of PTS-receptor docking complexes. Pubmed 3.050E-5 7.244E-3
7.096E-2
3.075E-1
 2 3
30 17510655:gr Conserved roles of Sam50 and metaxins in VDAC biogenesis. GeneRIF 3.050E-5 7.244E-3
7.096E-2
3.075E-1
 2 3
31 10072511 Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes. Pubmed 3.050E-5 7.244E-3
7.096E-2
3.075E-1
 2 3
32 17510655 Conserved roles of Sam50 and metaxins in VDAC biogenesis. Pubmed 3.050E-5 7.244E-3
7.096E-2
3.075E-1
 2 3
33 14715663:gr Potential role for Pex19p in assembly of PTS-receptor docking complexes. GeneRIF 3.050E-5 7.244E-3
7.096E-2
3.075E-1
 2 3
34 19716793 EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis. Pubmed 3.050E-5 7.244E-3
7.096E-2
3.075E-1
 2 3
35 24163370 The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. Pubmed 3.878E-5 7.244E-3
7.096E-2
3.910E-1
 7 283
36 10931946 Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. Pubmed 4.306E-5 7.244E-3
7.096E-2
4.342E-1
 5 119
37 20532202:gr Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. GeneRIF 5.444E-5 7.244E-3
7.096E-2
5.489E-1
 3 23
38 20532202 Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. Pubmed 5.444E-5 7.244E-3
7.096E-2
5.489E-1
 3 23
39 22114354 MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. Pubmed 5.444E-5 7.244E-3
7.096E-2
5.489E-1
 3 23
40 21906983 Systematic and quantitative assessment of the ubiquitin-modified proteome. Pubmed 5.874E-5 7.244E-3
7.096E-2
5.922E-1
 6 207
41 22248718 miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Pubmed 6.087E-5 7.244E-3
7.096E-2
6.137E-1
 2 4
42 9349823 A SNARE involved in protein transport through the Golgi apparatus. Pubmed 6.087E-5 7.244E-3
7.096E-2
6.137E-1
 2 4
43 17018283 RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. Pubmed 6.087E-5 7.244E-3
7.096E-2
6.137E-1
 2 4
44 24480751 Immunoneuropathogenesis of HIV-1 clades B and C: role of redox expression and thiol modification. Pubmed 6.087E-5 7.244E-3
7.096E-2
6.137E-1
 2 4
45 18782765 Targeting of hFis1 to peroxisomes is mediated by Pex19p. Pubmed 6.087E-5 7.244E-3
7.096E-2
6.137E-1
 2 4
46 20097730 Antioxidant genes, diabetes and dietary antioxidants in association with risk of pancreatic cancer. Pubmed 6.087E-5 7.244E-3
7.096E-2
6.137E-1
 2 4
47 20097730:gr Antioxidant genes, diabetes and dietary antioxidants in association with risk of pancreatic cancer. GeneRIF 6.087E-5 7.244E-3
7.096E-2
6.137E-1
 2 4
48 22248718:gr miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. GeneRIF 6.087E-5 7.244E-3
7.096E-2
6.137E-1
 2 4
49 21890473 A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Pubmed 6.194E-5 7.244E-3
7.096E-2
6.246E-1
 6 209
50 27107012 Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Pubmed 6.529E-5 7.244E-3
7.096E-2
6.583E-1
 6 211
Show 45 more annotations

9: Interaction [Display Chart] 3137 annotations before applied cutoff / 16534 genes in category

No results to display

10: Cytoband [Display Chart] 133 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17q21 17q21 2.262E-4 3.009E-2
1.646E-1
 3.009E-2 4 63

11: Transcription Factor Binding Site [Display Chart] 310 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 68 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 957 AAA ATPases|Peroxins genenames.org 6.051E-5 4.115E-3 1.977E-2 4.115E-3 3 16
2 83 Zinc fingers HIT-type genenames.org 3.504E-4 1.191E-2
5.724E-2
 2.383E-2 2 6
3 963 Methyltransferase like genenames.org 5.551E-4 1.258E-2
6.045E-2
 3.775E-2 3 33
4 690 Proteasome genenames.org 1.212E-3 2.061E-2
9.900E-2
8.243E-2
 3 43
5 1059 Lysine acetyltransferases|ATAC complex|SAGA complex|GCN5 related N-acetyltransferases genenames.org 3.068E-3 3.723E-2
1.789E-1
2.086E-1
 2 17
6 132 Aminoacyl tRNA synthetases, Class II genenames.org 3.833E-3 3.723E-2
1.789E-1
2.606E-1
 2 19
7 909 Tetratricopeptide repeat domain containing|Cyclophilin peptidylprolyl isomerases genenames.org 3.833E-3 3.723E-2
1.789E-1
2.606E-1
 2 19
8 680 Phosphatidylinositol glycan anchor biosynthesis genenames.org 4.677E-3 3.976E-2
1.910E-1
3.181E-1
 2 21
9 615 Intraflagellar transport proteins|Tetratricopeptide repeat domain containing genenames.org 6.089E-3 4.601E-2
2.210E-1
4.141E-1
 2 24
10 646 Mitochondrial ribosomal proteins genenames.org 6.845E-3 4.655E-2
2.236E-1
4.655E-1
 3 79
Show 5 more annotations

13: Coexpression [Display Chart] 5249 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13893 Genes down-regulated in Daudi cells (B lymphocytes) stably expressing CD5 [GeneID=921] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.274E-13 1.194E-9 1.091E-8 1.194E-9 23 431
2 GSE19888 ADENOSINE A3R ACT VS A3R ACT WITH A3R INH PRETREATMENT IN MAST CELL UP Genes up-regulated in HMC-1 (mast leukemia) cells: Cl-IB-MECA [PubChem=3035850] versus incubated with the ALL1 peptide followed by treatment with Cl-IB-MECA [PubChem=3035850]. MSigDB C7: Immunologic Signatures (v5.1) 3.710E-7 6.825E-4 6.240E-3 1.948E-3 11 199
3 M5843 Genes down-regulated in comparison of virus specific (gp33) exhausted CD8 T cells versus the virus specific (gp276) cells. MSigDB C7: Immunologic Signatures (v5.1) 3.901E-7 6.825E-4 6.240E-3 2.048E-3 11 200
4 M6896 Genes down-regulated in macrophages with IL10 [GeneID=3586] knockout in response to 10 min treatment by: LPS versus LPS and IL10 [GeneID=3586]. MSigDB C7: Immunologic Signatures (v5.1) 3.155E-6 1.840E-3 1.682E-2 1.656E-2 10 200
5 GSE41867 DAY6 VS DAY8 LCMV ARMSTRONG EFFECTOR CD8 TCELL DN Genes down-regulated in CD8 T effector cells, acute infection with LCMV-Armstrong: day 6 versus day 8. MSigDB C7: Immunologic Signatures (v5.1) 3.155E-6 1.840E-3 1.682E-2 1.656E-2 10 200
6 GSE22432 MULTIPOTENT VS COMMON DC PROGENITOR UNTREATED UP Genes up-regulated in amplified multipotent progenitors versus cultured untreated common dendritic cell progenitors. MSigDB C7: Immunologic Signatures (v5.1) 3.155E-6 1.840E-3 1.682E-2 1.656E-2 10 200
7 GSE17186 NAIVE VS CD21HIGH TRANSITIONAL BCELL CORD BLOOD UP Genes up-regulated in B lymphocytes from cord blood: naïve versus transitional CR2 [GeneID=1380] high. MSigDB C7: Immunologic Signatures (v5.1) 3.155E-6 1.840E-3 1.682E-2 1.656E-2 10 200
8 GSE37532 WT VS PPARG KO VISCERAL ADIPOSE TISSUE TCONV DN Genes down-regulated in T conv from visceral adipose tissue in aged mice: wildtype versus PPARG [GeneID=5468] knockout. MSigDB C7: Immunologic Signatures (v5.1) 3.155E-6 1.840E-3 1.682E-2 1.656E-2 10 200
9 GSE15330 GRANULOCYTE MONOCYTE PROGENITOR VS PRO BCELL UP Genes up-regulated in granulo-monocyte progenitors versus pro-B lymphocytes. MSigDB C7: Immunologic Signatures (v5.1) 3.155E-6 1.840E-3 1.682E-2 1.656E-2 10 200
10 GSE14415 TCONV VS FOXP3 KO INDUCED TREG UP Genes up-regulated in T conv versus induced T reg with non-functional FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v5.1) 5.409E-6 2.710E-3 2.478E-2 2.839E-2 9 167
11 GSE13547 CTRL VS ANTI IGM STIM ZFX KO BCELL 2H DN Genes down-regulated in B lymphocytes with ZFX [GeneID=7543] knockout: control versus stimulated by anti-IgM for 2h. MSigDB C7: Immunologic Signatures (v5.1) 5.679E-6 2.710E-3 2.478E-2 2.981E-2 9 168
12 GSE22432 MULTIPOTENT VS COMMON DC PROGENITOR UP Genes up-regulated in amplified: multipotent progenitors versus common dendritic cell progenitors. MSigDB C7: Immunologic Signatures (v5.1) 2.209E-5 6.703E-3
6.129E-2
1.160E-1
 9 199
13 M5905 Genes up-regulated during adipocyte differentiation (adipogenesis). MSigDB H: Hallmark Gene Sets (v5.1) 2.299E-5 6.703E-3
6.129E-2
1.207E-1
 9 200
14 GSE16385 MONOCYTE VS 12H ROSIGLITAZONE TREATED MACROPHAGE DN Genes down-regulated in monocytes (12h) versus macrophages (12h) treated with rosiglitazone [PubChem=77999]. MSigDB C7: Immunologic Signatures (v5.1) 2.299E-5 6.703E-3
6.129E-2
1.207E-1
 9 200
15 M4083 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus those stimulated at 24 h. MSigDB C7: Immunologic Signatures (v5.1) 2.299E-5 6.703E-3
6.129E-2
1.207E-1
 9 200
16 M5743 Genes up-regulated in comparison of thymus regulatory T cells versus fat tissue regulatory T cells. MSigDB C7: Immunologic Signatures (v5.1) 2.299E-5 6.703E-3
6.129E-2
1.207E-1
 9 200
17 M6884 Genes up-regulated in monocytes after HCMV infection: BAY 11-7082 [PubChem=5353431] versus Ly294002 [PubChem=3973]. MSigDB C7: Immunologic Signatures (v5.1) 2.299E-5 6.703E-3
6.129E-2
1.207E-1
 9 200
18 M6185 Genes down-regulated in C57BL6 CD4 CD8 double positive thymocyte transgenic for the BDC2.5 TCR incubated with no peptide 0h versus C57BL6 CD4 CD8 double positive thymocyte transgenic for the BDC2.5 TCR incubated with mimetope negative sel 16h. MSigDB C7: Immunologic Signatures (v5.1) 2.299E-5 6.703E-3
6.129E-2
1.207E-1
 9 200
19 M2250 Up-regulated genes whose expression profile is specific to Custer I of urothelial cell carcinoma (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.709E-5 1.025E-2
9.368E-2
1.947E-1
 7 120
20 M6823 Genes up-regulated in dendritic cells: anti-FcgRIIB versus inflammatory cytokine cocktail. MSigDB C7: Immunologic Signatures (v5.1) 8.395E-5 1.694E-2
1.549E-1
4.407E-1
 8 184
21 M4846 Genes up-regulated in comparison of CD8 T cells versus neutrophils. MSigDB C7: Immunologic Signatures (v5.1) 1.445E-4 1.694E-2
1.549E-1
7.584E-1
 8 199
22 GSE21546 WT VS SAP1A KO ANTI CD3 STIM DP THYMOCYTES DN Genes down-regulated in double positive thymocytes stimulated by anti-CD3: wildtype versus ELK4 [GeneID=2005] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.445E-4 1.694E-2
1.549E-1
7.584E-1
 8 199
23 GSE11961 MARGINAL ZONE BCELL VS PLASMA CELL DAY7 UP Genes up-regulated in marginal zone B cells versus day 7 plasma cells. MSigDB C7: Immunologic Signatures (v5.1) 1.445E-4 1.694E-2
1.549E-1
7.584E-1
 8 199
24 GSE37301 LYMPHOID PRIMED MPP VS GRAN MONO PROGENITOR UP Genes up-regulated in lymphoid primed multipotent progenitors versus granulocyte-monocyte progenitors. MSigDB C7: Immunologic Signatures (v5.1) 1.445E-4 1.694E-2
1.549E-1
7.584E-1
 8 199
25 GSE34156 NOD2 LIGAND VS NOD2 AND TLR1 TLR2 LIGAND 6H TREATED MONOCYTE UP Genes up-regulated in monocytes (6h): muramyl dipeptide [PubChem=11620162] versus muramyl dipeptide [PubChem=11620162] and M. tuberculosis 19 kDa lipopeptide. MSigDB C7: Immunologic Signatures (v5.1) 1.445E-4 1.694E-2
1.549E-1
7.584E-1
 8 199
26 GSE12484 HEALTHY VS PERIDONTITIS NEUTROPHILS DN Genes down-regulated in neutrophils isolated from: healthy versus patients with peridontitis. MSigDB C7: Immunologic Signatures (v5.1) 1.455E-4 1.694E-2
1.549E-1
7.637E-1
 7 149
27 M3830 Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 2 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 2 h. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
28 M4004 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 8 h. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
29 M3937 Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 2 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 2 h. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
30 GSE21927 GMCSF IL6 VS GMCSF GCSF TREATED BONE MARROW DN Genes down-regulated in CD11b BoneMarrow from BALBc mouse incubated with GMCSF and IL-6 versus CD11b BoneMarrow from BALBc mouse incubated with GMCSF and GCSF. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
31 M4266 Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 8 h. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
32 M3573 Genes up-regulated in comparison of wild type CD8 effector T cells at day 10 versus those from mice defficient for TRAF6 [GeneID=7189] at day 10. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
33 M5429 Genes up-regulated in comparison of mast cells versus macrophages. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
34 GSE15330 HSC VS LYMPHOID PRIMED MULTIPOTENT PROGENITOR IKAROS KO DN Genes down-regulated in IKZF1 [GeneID=10320] knockout: hematopoietic stem cells versus lymphoid-primed multipotent progenitors. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
35 GSE41867 NAIVE VS EFFECTOR CD8 TCELL UP Genes up-regulated in CD8 T cells: naïve versus effectors. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
36 GSE41867 NAIVE VS DAY30 LCMV ARMSTRONG MEMORY CD8 TCELL DN Genes down-regulated in CD8 T cells: naïve versus memory at day 30 after acute infection with LCMV-Armstrong. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
37 GSE21927 BALBC VS C57BL6 MONOCYTE TUMOR UP Genes up-regulated in CD11b Tumor from BALBc mouse versus CD11b Tumor from C57BL6 mouse. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
38 M4262 Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 6 h. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
39 GSE37533 PPARG1 FOXP3 VS FOXP3 TRANSDUCED CD4 TCELL UP Genes up-regulated in CD4 [GeneID=920] over-expressing: FOXP3 [GeneID=50943] and PPARg1 form of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
40 M3820 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 24 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 24 h. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
41 GSE5503 MLN DC VS SPLEEN DC ACTIVATED ALLOGENIC TCELL DN Genes down-regulated in allogeneic T cells after stimulation with dendritic cells from: mesenteric lymph nodes (mLN) versus spleen. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
42 M6930 Genes up-regulated in B lymphocytes: anti IgM versus PL2-3 (Chromatin IC). MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
43 M5533 Genes down-regulated in comparison of neutrophils versus Th1 cells. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
44 M6832 Genes up-regulated in response to anti-FcgRIIB: dendritic cells versus monocytes. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
45 M4271 Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 12 h. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
46 M4096 Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus those stimulated at 24 h. MSigDB C7: Immunologic Signatures (v5.1) 1.495E-4 1.694E-2
1.549E-1
7.850E-1
 8 200
47 GSE37605 TREG VS TCONV C57BL6 FOXP3 IRES GFP DN Genes down-regulated in splenocytes from Foxp3-ires-GFP B6 mice: T reg (FOXP3+ [GeneID=50943]) versus T conv (FOXP3- [GeneID=50943]). MSigDB C7: Immunologic Signatures (v5.1) 1.517E-4 1.694E-2
1.549E-1
7.961E-1
 7 150
48 GSE14415 ACT VS CTRL NATURAL TREG DN Genes down-regulated in natural T reg: activated versus naïve. MSigDB C7: Immunologic Signatures (v5.1) 2.625E-4 2.870E-2
2.624E-1
1.000E0
 7 164
49 M18562 Genes down-regulated in response to both hypoxia and overexpression of an active form of HIF1A [GeneID=3091]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.770E-4 4.038E-2
3.692E-1
1.000E0
 9 289
50 M1919 Genes up-regulated in MEF cells (embryonic fibroblast) with double knockout of the translation repressors 4EBP1 [GeneID=1978] and 4EBP2 [GeneID=1979]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.061E-4 4.263E-2
3.898E-1
1.000E0
 10 356
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 1662 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Facebase ST1 e8.5 NeuroEpith nonFloorPlate 500 2 e8.5 NeuroEpith nonFloorPlate top-relative-expression-ranked 500 2 FaceBase_ST1 1.947E-6 3.236E-3 2.586E-2 3.236E-3 13 326
2 neurons SubClass neurons all Top 500 Cluster 4 neurons SubClass neurons all Top 500 Cluster 4 Brain Map - Barres 1.614E-5 1.203E-2
9.613E-2
 2.683E-2 8 141
3 Facebase ST1 e8.5 NeuroEpith FloorPlate 500 e8.5 NeuroEpith FloorPlate top-relative-expression-ranked 500 FaceBase_ST1 2.171E-5 1.203E-2
9.613E-2
 3.608E-2 13 408
4 54SK SubClass 54SK 1 Top 500 Cluster 2 54SK SubClass 54SK 1 Top 500 Cluster 2 Brain Map - Allen iN 6.419E-5 2.667E-2
2.132E-1
1.067E-1
 8 171
5 Lungmap Mouse e16.5 Proliferative fibroblast SubClass Proliferative Myofibroblast Top 500 Cluster 0 Mouse Lung E16.5 Proliferative fibroblast Proliferative Myofibroblast c0 Lungmap Mouse Single Cell (Lungmap.net) 9.950E-5 2.669E-2
2.134E-1
1.654E-1
 6 94
6 ratio ECTO vs SC 2500 K2 ratio induced-Ectoderm vs StemCell top-relative-expression-ranked 2500 k-means-cluster#2 PCBC 1.247E-4 2.669E-2
2.134E-1
2.073E-1
 12 419
7 Facebase RNAseq e8.5 Floor Plate 1000 K3 FacebaseRNAseq e8.5 Floor Plate top-relative-expression-ranked 1000 k-means-cluster#3 FaceBase_RNAseq 1.262E-4 2.669E-2
2.134E-1
2.098E-1
 10 297
8 54SK SubClass 54SK 2 Top 500 All 54SK SubClass 54SK 2 Top 500 All Brain Map - Allen iN 1.285E-4 2.669E-2
2.134E-1
2.136E-1
 13 486
9 gudmap developingKidney e11.5 metaneph mesench 1000 k3 DevelopingKidney e11.5 metaneph mesench emap-3843 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.994E-4 3.682E-2
2.943E-1
3.314E-1
 11 376
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15: Computational [Display Chart] 344 annotations before applied cutoff / 9399 genes in category

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16: MicroRNA [Display Chart] 871 annotations before applied cutoff / 19844 genes in category

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17: Drug [Display Chart] 15951 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C089595 cylindrospermopsin CTD 1.045E-7 1.061E-3 1.088E-2 1.667E-3 17 471
2 3963 DN Lanatoside C [17575-22-3]; Down 200; 4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.521E-7 1.061E-3 1.088E-2 2.427E-3 11 184
3 5677 DN Bisacodyl [603-50-9]; Down 200; 11uM; MCF7; HT HG-U133A Broad Institute CMAP 1.995E-7 1.061E-3 1.088E-2 3.182E-3 11 189
4 5026 DN Strophantine octahydrate [11018-89-6]; Down 200; 5.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.004E-6 3.546E-3 3.636E-2 1.601E-2 10 178
5 4404 DN Proscillaridin A [466-06-8]; Down 200; 7.6uM; MCF7; HT HG-U133A Broad Institute CMAP 1.111E-6 3.546E-3 3.636E-2 1.773E-2 10 180
6 1339 DN Digitoxigenin [143-62-4]; Down 200; 10.6uM; HL60; HT HG-U133A Broad Institute CMAP 1.497E-6 3.793E-3 3.890E-2 2.388E-2 10 186
7 6710 DN Diltiazem hydrochloride [33286-22-5]; Down 200; 8.8uM; PC3; HT HG-U133A Broad Institute CMAP 1.902E-6 3.793E-3 3.890E-2 3.035E-2 10 191
8 1302 DN Strophantine octahydrate [11018-89-6]; Down 200; 5.4uM; HL60; HT HG-U133A Broad Institute CMAP 1.902E-6 3.793E-3 3.890E-2 3.035E-2 10 191
9 5344 DN Metergoline [17692-51-2]; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 2.513E-6 4.453E-3 4.567E-2 4.008E-2 10 197
10 5324 DN Digoxin [20830-75-5]; Down 200; 5.2uM; MCF7; HT HG-U133A Broad Institute CMAP 9.984E-6 1.593E-2
1.633E-1
1.593E-1
 9 182
11 1221 DN Rapamycin; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.664E-5 2.400E-2
2.462E-1
2.654E-1
 9 194
12 5463 DN Ifenprodil tartrate [23210-58-4]; Down 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.879E-5 2.400E-2
2.462E-1
2.998E-1
 9 197
13 1042 DN aspirin, USP; Down 200; 100uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.956E-5 2.400E-2
2.462E-1
3.121E-1
 9 198
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18: Disease [Display Chart] 1478 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0282527 Infantile Refsum Disease (disorder) DisGeNET Curated 4.016E-7 5.936E-4 4.675E-3 5.936E-4 5 21
2 umls:C0043459 Zellweger Syndrome DisGeNET Curated 2.665E-6 1.395E-3 1.099E-2 3.939E-3 5 30
3 umls:C0282525 Adrenoleukodystrophy, Neonatal DisGeNET Curated 2.832E-6 1.395E-3 1.099E-2 4.186E-3 4 14
4 umls:C1832200 Peroxisome biogenesis disorders DisGeNET Curated 2.378E-5 8.786E-3
6.920E-2
 3.514E-2 4 23
5 umls:C0751651 Mitochondrial Diseases DisGeNET Curated 5.767E-5 1.705E-2
1.343E-1
8.524E-2
 7 131
6 umls:C3658299 Zellweger Spectrum DisGeNET BeFree 1.111E-4 2.736E-2
2.155E-1
1.642E-1
 3 13
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