Toppgene analysis for aggregated_1964_log, IC16, positive side

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1: GO: Molecular Function [Display Chart] 567 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003779 actin binding 1.100E-15 6.234E-13 4.313E-12 6.234E-13 26 412
2 GO:0008307 structural constituent of muscle 4.755E-8 1.348E-5 9.326E-5 2.696E-5 7 41
3 GO:0051015 actin filament binding 2.073E-7 3.918E-5 2.711E-4 1.175E-4 10 134
4 GO:0005523 tropomyosin binding 4.598E-6 6.518E-4 4.509E-3 2.607E-3 4 14
5 GO:0031013 troponin I binding 5.845E-6 6.629E-4 4.586E-3 3.314E-3 3 5
6 GO:0005516 calmodulin binding 3.636E-5 3.017E-3 2.087E-2 2.062E-2 9 191
7 GO:0000146 microfilament motor activity 3.833E-5 3.017E-3 2.087E-2 2.173E-2 4 23
8 GO:0005200 structural constituent of cytoskeleton 4.382E-5 3.017E-3 2.087E-2 2.485E-2 7 111
9 GO:0051371 muscle alpha-actinin binding 4.789E-5 3.017E-3 2.087E-2 2.716E-2 3 9
10 GO:0004860 protein kinase inhibitor activity 1.079E-4 5.817E-3 4.025E-2
6.116E-2
 6 89
11 GO:0019210 kinase inhibitor activity 1.220E-4 5.817E-3 4.025E-2
6.919E-2
 6 91
12 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1.231E-4 5.817E-3 4.025E-2
6.981E-2
 3 12
13 GO:0030172 troponin C binding 2.116E-4 8.850E-3
6.122E-2
1.200E-1
 2 3
14 GO:0042805 actinin binding 2.341E-4 8.850E-3
6.122E-2
1.327E-1
 4 36
15 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2.341E-4 8.850E-3
6.122E-2
1.327E-1
 4 36
16 GO:0019887 protein kinase regulator activity 2.661E-4 9.431E-3
6.525E-2
1.509E-1
 8 196
17 GO:0017018 myosin phosphatase activity 4.209E-4 1.326E-2
9.173E-2
2.387E-1
 2 4
18 GO:0031014 troponin T binding 4.209E-4 1.326E-2
9.173E-2
2.387E-1
 2 4
19 GO:0019207 kinase regulator activity 5.252E-4 1.567E-2
1.084E-1
2.978E-1
 8 217
20 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 6.976E-4 1.978E-2
1.368E-1
3.956E-1
 2 5
21 GO:0004111 creatine kinase activity 1.041E-3 2.810E-2
1.944E-1
5.900E-1
 2 6
22 GO:0051393 alpha-actinin binding 1.187E-3 3.060E-2
2.117E-1
6.733E-1
 3 25
23 GO:0050840 extracellular matrix binding 1.368E-3 3.373E-2
2.334E-1
7.758E-1
 4 57
24 GO:0005080 protein kinase C binding 1.870E-3 4.357E-2
3.014E-1
1.000E0
 4 62
25 GO:0097493 structural molecule activity conferring elasticity 1.921E-3 4.357E-2
3.014E-1
1.000E0
 2 8
26 GO:0030291 protein serine/threonine kinase inhibitor activity 2.032E-3 4.432E-2
3.066E-1
1.000E0
 3 30
Show 21 more annotations

2: GO: Biological Process [Display Chart] 2790 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030049 muscle filament sliding 1.878E-23 4.265E-20 3.630E-19 5.240E-20 16 40
2 GO:0033275 actin-myosin filament sliding 3.058E-23 4.265E-20 3.630E-19 8.531E-20 16 41
3 GO:0070252 actin-mediated cell contraction 5.470E-22 5.087E-19 4.330E-18 1.526E-18 20 102
4 GO:0030048 actin filament-based movement 1.506E-21 1.050E-18 8.940E-18 4.202E-18 21 125
5 GO:0003012 muscle system process 4.047E-21 2.258E-18 1.922E-17 1.129E-17 32 433
6 GO:0006936 muscle contraction 1.947E-18 9.054E-16 7.706E-15 5.432E-15 27 348
7 GO:0006941 striated muscle contraction 3.700E-14 1.475E-11 1.255E-10 1.032E-10 17 161
8 GO:0055001 muscle cell development 3.103E-13 1.082E-10 9.209E-10 8.656E-10 17 183
9 GO:0030239 myofibril assembly 4.230E-12 1.311E-9 1.116E-8 1.180E-8 11 62
10 GO:0007517 muscle organ development 6.284E-12 1.753E-9 1.492E-8 1.753E-8 22 410
11 GO:0042692 muscle cell differentiation 7.972E-12 2.022E-9 1.721E-8 2.224E-8 22 415
12 GO:0055002 striated muscle cell development 1.455E-11 3.383E-9 2.879E-8 4.059E-8 15 168
13 GO:0051146 striated muscle cell differentiation 5.030E-10 1.079E-7 9.188E-7 1.403E-6 17 291
14 GO:0090257 regulation of muscle system process 7.534E-10 1.501E-7 1.278E-6 2.102E-6 15 222
15 GO:0006937 regulation of muscle contraction 1.535E-9 2.855E-7 2.430E-6 4.282E-6 13 164
16 GO:0045214 sarcomere organization 1.749E-9 3.049E-7 2.595E-6 4.879E-6 8 41
17 GO:0003009 skeletal muscle contraction 2.616E-9 4.293E-7 3.654E-6 7.298E-6 8 43
18 GO:0043501 skeletal muscle adaptation 3.801E-9 5.891E-7 5.014E-6 1.060E-5 7 29
19 GO:0060048 cardiac muscle contraction 7.538E-9 1.107E-6 9.421E-6 2.103E-5 11 122
20 GO:0014888 striated muscle adaptation 9.208E-9 1.285E-6 1.093E-5 2.569E-5 8 50
21 GO:0014883 transition between fast and slow fiber 1.025E-8 1.315E-6 1.119E-5 2.860E-5 5 10
22 GO:0006695 cholesterol biosynthetic process 1.084E-8 1.315E-6 1.119E-5 3.025E-5 8 51
23 GO:1902653 secondary alcohol biosynthetic process 1.084E-8 1.315E-6 1.119E-5 3.025E-5 8 51
24 GO:0031032 actomyosin structure organization 1.652E-8 1.921E-6 1.635E-5 4.610E-5 12 164
25 GO:0050881 musculoskeletal movement 2.014E-8 2.162E-6 1.840E-5 5.620E-5 8 55
26 GO:0050879 multicellular organismal movement 2.014E-8 2.162E-6 1.840E-5 5.620E-5 8 55
27 GO:0016126 sterol biosynthetic process 2.333E-8 2.411E-6 2.052E-5 6.510E-5 8 56
28 GO:0014706 striated muscle tissue development 6.005E-8 5.984E-6 5.093E-5 1.676E-4 17 401
29 GO:0060537 muscle tissue development 1.128E-7 1.085E-5 9.235E-5 3.147E-4 17 419
30 GO:0014733 regulation of skeletal muscle adaptation 2.399E-7 2.231E-5 1.899E-4 6.693E-4 5 17
31 GO:0043500 muscle adaptation 2.593E-7 2.333E-5 1.986E-4 7.233E-4 9 104
32 GO:1903115 regulation of actin filament-based movement 6.495E-7 5.663E-5 4.820E-4 1.812E-3 6 37
33 GO:0008203 cholesterol metabolic process 2.356E-6 1.992E-4 1.696E-3 6.575E-3 9 135
34 GO:0042326 negative regulation of phosphorylation 3.041E-6 2.495E-4 2.124E-3 8.485E-3 16 474
35 GO:1902652 secondary alcohol metabolic process 3.184E-6 2.538E-4 2.160E-3 8.884E-3 9 140
36 GO:0043502 regulation of muscle adaptation 3.808E-6 2.951E-4 2.512E-3 1.062E-2 7 76
37 GO:0060047 heart contraction 4.460E-6 3.363E-4 2.862E-3 1.244E-2 12 276
38 GO:0003015 heart process 4.981E-6 3.597E-4 3.061E-3 1.390E-2 12 279
39 GO:0016125 sterol metabolic process 5.028E-6 3.597E-4 3.061E-3 1.403E-2 9 148
40 GO:0032970 regulation of actin filament-based process 7.865E-6 5.486E-4 4.669E-3 2.194E-2 13 343
41 GO:0006942 regulation of striated muscle contraction 8.063E-6 5.487E-4 4.670E-3 2.250E-2 7 85
42 GO:0046165 alcohol biosynthetic process 9.476E-6 6.295E-4 5.358E-3 2.644E-2 9 160
43 GO:0006469 negative regulation of protein kinase activity 9.720E-6 6.306E-4 5.368E-3 2.712E-2 11 249
44 GO:0010694 positive regulation of alkaline phosphatase activity 1.190E-5 7.547E-4 6.424E-3 3.321E-2 3 6
45 GO:0048738 cardiac muscle tissue development 1.665E-5 1.032E-3 8.787E-3 4.646E-2 10 216
46 GO:0033673 negative regulation of kinase activity 2.450E-5 1.486E-3 1.265E-2
6.836E-2
 11 275
47 GO:0010927 cellular component assembly involved in morphogenesis 3.376E-5 2.004E-3 1.706E-2
9.419E-2
 12 338
48 GO:0003300 cardiac muscle hypertrophy 3.694E-5 2.147E-3 1.828E-2
1.031E-1
 6 73
49 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 3.956E-5 2.253E-3 1.917E-2
1.104E-1
 4 23
50 GO:0014897 striated muscle hypertrophy 4.646E-5 2.592E-3 2.206E-2
1.296E-1
 6 76
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 277 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043292 contractile fiber 3.072E-32 5.859E-30 3.635E-29 8.510E-30 34 235
2 GO:0044449 contractile fiber part 4.231E-32 5.859E-30 3.635E-29 1.172E-29 33 216
3 GO:0030017 sarcomere 1.258E-27 8.920E-26 5.533E-25 3.485E-25 29 199
4 GO:0030016 myofibril 1.288E-27 8.920E-26 5.533E-25 3.568E-25 30 221
5 GO:0015629 actin cytoskeleton 7.754E-18 4.296E-16 2.665E-15 2.148E-15 30 478
6 GO:0005865 striated muscle thin filament 4.796E-17 2.214E-15 1.373E-14 1.329E-14 11 25
7 GO:0036379 myofilament 3.615E-16 1.431E-14 8.875E-14 1.001E-13 11 29
8 GO:0030018 Z disc 1.803E-12 6.242E-11 3.872E-10 4.994E-10 14 120
9 GO:0005859 muscle myosin complex 2.653E-12 8.165E-11 5.065E-10 7.348E-10 8 20
10 GO:0005861 troponin complex 9.508E-12 2.565E-10 1.591E-9 2.634E-9 6 8
11 GO:0031674 I band 1.018E-11 2.565E-10 1.591E-9 2.821E-9 14 136
12 GO:0016460 myosin II complex 4.445E-11 1.026E-9 6.365E-9 1.231E-8 8 27
13 GO:0016459 myosin complex 5.966E-9 1.271E-7 7.886E-7 1.653E-6 9 68
14 GO:0031672 A band 7.030E-8 1.391E-6 8.628E-6 1.947E-5 7 43
15 GO:0032982 myosin filament 1.242E-6 2.293E-5 1.423E-4 3.440E-4 5 23
16 GO:0031430 M band 3.931E-5 6.805E-4 4.221E-3 1.089E-2 4 23
17 GO:0005924 cell-substrate adherens junction 6.156E-4 1.003E-2
6.222E-2
1.705E-1
 11 398
18 GO:0030055 cell-substrate junction 6.823E-4 1.030E-2
6.389E-2
1.890E-1
 11 403
19 GO:0030485 smooth muscle contractile fiber 7.064E-4 1.030E-2
6.389E-2
1.957E-1
 2 5
20 GO:0043034 costamere 8.250E-4 1.143E-2
7.088E-2
2.285E-1
 3 22
21 GO:0014704 intercalated disc 1.593E-3 2.101E-2
1.304E-1
4.413E-1
 4 59
22 GO:0030315 T-tubule 1.696E-3 2.135E-2
1.324E-1
4.697E-1
 4 60
23 GO:0030175 filopodium 1.792E-3 2.159E-2
1.339E-1
4.965E-1
 5 102
24 GO:0005925 focal adhesion 2.003E-3 2.205E-2
1.368E-1
5.549E-1
 10 393
25 GO:0008305 integrin complex 2.069E-3 2.205E-2
1.368E-1
5.732E-1
 3 30
26 GO:0098636 protein complex involved in cell adhesion 2.069E-3 2.205E-2
1.368E-1
5.732E-1
 3 30
27 GO:0005912 adherens junction 2.913E-3 2.988E-2
1.854E-1
8.069E-1
 11 484
28 GO:0044291 cell-cell contact zone 3.307E-3 3.272E-2
2.029E-1
9.160E-1
 4 72
29 GO:0014069 postsynaptic density 4.315E-3 3.984E-2
2.471E-1
1.000E0
 7 238
30 GO:0099572 postsynaptic specialization 4.315E-3 3.984E-2
2.471E-1
1.000E0
 7 238
31 GO:0098794 postsynapse 5.555E-3 4.964E-2
3.079E-1
1.000E0
 10 454
Show 26 more annotations

4: Human Phenotype [Display Chart] 675 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0003458 EMG: myopathic abnormalities 9.665E-8 6.524E-5 4.627E-4 6.524E-5 7 31
2 HP:0003324 Generalized muscle weakness 4.022E-6 1.357E-3 9.627E-3 2.715E-3 6 34
3 HP:0005110 Atrial fibrillation 7.926E-6 1.401E-3 9.939E-3 5.350E-3 6 38
4 HP:0003803 Type 1 muscle fiber predominance 8.304E-6 1.401E-3 9.939E-3 5.605E-3 4 11
5 HP:0002804 Arthrogryposis multiplex congenita 1.181E-5 1.594E-3 1.131E-2 7.970E-3 7 61
6 HP:0001644 Dilated cardiomyopathy 1.422E-5 1.600E-3 1.135E-2 9.599E-3 8 87
7 HP:0030682 Left ventricular noncompaction 2.446E-5 2.358E-3 1.673E-2 1.651E-2 4 14
8 HP:0001283 Bulbar palsy 3.082E-5 2.600E-3 1.844E-2 2.080E-2 5 29
9 HP:0003701 Proximal muscle weakness 3.902E-5 2.652E-3 1.881E-2 2.634E-2 7 73
10 HP:0002515 Waddling gait 4.039E-5 2.652E-3 1.881E-2 2.726E-2 6 50
11 HP:0001699 Sudden death 4.321E-5 2.652E-3 1.881E-2 2.917E-2 5 31
12 HP:0000218 High palate {has synonym type="layperson"} 5.508E-5 3.098E-3 2.198E-2 3.718E-2 12 243
13 HP:0003687 Centrally nucleated skeletal muscle fibers 9.015E-5 4.057E-3 2.877E-2
6.085E-2
 4 19
14 HP:0002058 Myopathic facies 9.015E-5 4.057E-3 2.877E-2
6.085E-2
 4 19
15 HP:0003445 EMG: neuropathic changes 9.015E-5 4.057E-3 2.877E-2
6.085E-2
 4 19
16 HP:0002747 Respiratory insufficiency due to muscle weakness 1.653E-4 6.973E-3 4.946E-2
1.116E-1
 6 64
17 HP:0003798 Nemaline bodies 2.427E-4 9.102E-3
6.456E-2
1.638E-1
 3 10
18 HP:0005684 Distal arthrogryposis 2.427E-4 9.102E-3
6.456E-2
1.638E-1
 3 10
19 HP:0003722 Neck flexor weakness 3.306E-4 1.175E-2
8.331E-2
2.232E-1
 3 11
20 HP:0003302 Spondylolisthesis 4.367E-4 1.474E-2
1.045E-1
2.948E-1
 3 12
21 HP:0001558 Decreased fetal movement 4.912E-4 1.484E-2
1.053E-1
3.316E-1
 6 78
22 HP:0012727 Thoracic aortic aneurysm 5.058E-4 1.484E-2
1.053E-1
3.414E-1
 2 3
23 HP:0009054 Scapuloperoneal myopathy 5.058E-4 1.484E-2
1.053E-1
3.414E-1
 2 3
24 HP:0000508 Ptosis 8.132E-4 2.287E-2
1.622E-1
5.489E-1
 11 278
25 HP:0003704 Scapuloperoneal weakness 1.003E-3 2.507E-2
1.778E-1
6.770E-1
 2 4
26 HP:0004942 Aortic aneurysm 1.003E-3 2.507E-2
1.778E-1
6.770E-1
 2 4
27 HP:0003044 Shoulder flexion contracture 1.003E-3 2.507E-2
1.778E-1
6.770E-1
 2 4
28 HP:0003691 Scapular winging 1.041E-3 2.510E-2
1.780E-1
7.028E-1
 4 35
29 HP:0002460 Distal muscle weakness 1.252E-3 2.914E-2
2.067E-1
8.452E-1
 6 93
30 HP:0010628 Facial palsy 1.324E-3 2.979E-2
2.113E-1
8.937E-1
 6 94
31 HP:0005272 Prominent nasolabial fold 1.657E-3 3.390E-2
2.405E-1
1.000E0
 2 5
32 HP:0004419 Recurrent thrombophlebitis 1.657E-3 3.390E-2
2.405E-1
1.000E0
 2 5
33 HP:0001193 Ulnar deviation of the hand or of fingers of the hand 1.657E-3 3.390E-2
2.405E-1
1.000E0
 2 5
34 HP:0000602 Ophthalmoplegia 1.712E-3 3.399E-2
2.411E-1
1.000E0
 5 67
35 HP:0003805 Rimmed vacuoles 1.802E-3 3.475E-2
2.464E-1
1.000E0
 3 19
36 HP:0003307 Hyperlordosis 2.078E-3 3.831E-2
2.717E-1
1.000E0
 4 42
37 HP:0004308 Ventricular arrhythmia 2.100E-3 3.831E-2
2.717E-1
1.000E0
 3 20
38 HP:0001284 Areflexia 2.171E-3 3.856E-2
2.735E-1
1.000E0
 7 140
39 HP:0001840 Metatarsus adductus 2.269E-3 3.870E-2
2.745E-1
1.000E0
 4 43
40 HP:0003306 Spinal rigidity 2.427E-3 3.870E-2
2.745E-1
1.000E0
 3 21
41 HP:0012209 Juvenile myelomonocytic leukemia 2.465E-3 3.870E-2
2.745E-1
1.000E0
 2 6
42 HP:0006109 Absent phalangeal crease 2.465E-3 3.870E-2
2.745E-1
1.000E0
 2 6
43 HP:0003715 Myofibrillar myopathy 2.465E-3 3.870E-2
2.745E-1
1.000E0
 2 6
44 HP:0011463 Childhood onset 2.824E-3 4.333E-2
3.073E-1
1.000E0
 5 75
45 HP:0002650 Scoliosis 3.107E-3 4.629E-2
3.283E-1
1.000E0
 11 328
46 HP:0001166 Arachnodactyly 3.154E-3 4.629E-2
3.283E-1
1.000E0
 4 47
47 HP:0003755 Type 1 fibers relatively smaller than type 2 fibers 3.422E-3 4.714E-2
3.344E-1
1.000E0
 2 7
48 HP:0001907 Thromboembolism 3.422E-3 4.714E-2
3.344E-1
1.000E0
 2 7
49 HP:0003810 Late-onset distal muscle weakness 3.422E-3 4.714E-2
3.344E-1
1.000E0
 2 7
50 HP:0002359 Frequent falls {has synonym type="layperson"} 3.592E-3 4.849E-2
3.439E-1
1.000E0
 3 24
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 2477 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004087 abnormal muscle fiber morphology 1.089E-8 2.697E-5 2.263E-4 2.697E-5 22 427
2 MP:0000759 abnormal skeletal muscle morphology 2.399E-8 2.971E-5 2.494E-4 5.943E-5 22 446
3 MP:0009398 abnormal skeletal muscle fiber size 4.247E-8 3.507E-5 2.943E-4 1.052E-4 13 151
4 MP:0004819 decreased skeletal muscle mass 1.020E-7 6.315E-5 5.300E-4 2.526E-4 12 135
5 MP:0009400 decreased skeletal muscle fiber size 2.830E-7 1.402E-4 1.176E-3 7.009E-4 10 96
6 MP:0004817 abnormal skeletal muscle mass 4.033E-7 1.665E-4 1.397E-3 9.990E-4 12 153
7 MP:0000738 impaired muscle contractility 1.526E-6 5.399E-4 4.531E-3 3.779E-3 16 313
8 MP:0005620 abnormal muscle contractility 1.871E-6 5.793E-4 4.862E-3 4.634E-3 18 398
9 MP:0003084 abnormal skeletal muscle fiber morphology 3.268E-6 8.995E-4 7.549E-3 8.096E-3 13 220
10 MP:0004091 abnormal Z lines 5.612E-6 1.390E-3 1.167E-2 1.390E-2 6 37
11 MP:0005140 decreased cardiac muscle contractility 6.438E-6 1.450E-3 1.217E-2 1.595E-2 13 234
12 MP:0001625 cardiac hypertrophy 7.192E-6 1.485E-3 1.246E-2 1.781E-2 12 201
13 MP:0004174 abnormal spine curvature 7.925E-6 1.510E-3 1.267E-2 1.963E-2 15 315
14 MP:0010579 increased heart left ventricle size 1.004E-5 1.777E-3 1.491E-2 2.488E-2 9 112
15 MP:0000160 kyphosis 2.454E-5 3.801E-3 3.190E-2
6.077E-2
 12 227
16 MP:0002625 heart left ventricle hypertrophy 2.455E-5 3.801E-3 3.190E-2
6.082E-2
 7 70
17 MP:0010578 abnormal heart left ventricle size 2.950E-5 4.234E-3 3.554E-2
7.308E-2
 9 128
18 MP:0009413 skeletal muscle fiber atrophy 3.077E-5 4.234E-3 3.554E-2
7.622E-2
 5 30
19 MP:0004090 abnormal sarcomere morphology 3.772E-5 4.917E-3 4.126E-2
9.342E-2
 6 51
20 MP:0009403 increased variability of skeletal muscle fiber size 4.711E-5 5.664E-3 4.753E-2
1.167E-1
 6 53
21 MP:0000761 thin diaphragm muscle 4.974E-5 5.664E-3 4.753E-2
1.232E-1
 5 33
22 MP:0002972 abnormal cardiac muscle contractility 5.031E-5 5.664E-3 4.753E-2
1.246E-1
 13 284
23 MP:0003358 abnormal hypaxial muscle morphology 1.189E-4 1.281E-2
1.075E-1
2.945E-1
 9 153
24 MP:0002279 abnormal diaphragm morphology 1.432E-4 1.478E-2
1.240E-1
3.547E-1
 7 92
25 MP:0003158 dysphagia 1.504E-4 1.490E-2
1.251E-1
3.726E-1
 3 9
26 MP:0008772 increased heart ventricle size 1.904E-4 1.814E-2
1.523E-1
4.717E-1
 10 200
27 MP:0002833 increased heart weight 2.327E-4 2.101E-2
1.763E-1
5.765E-1
 10 205
28 MP:0003560 osteoarthritis 2.375E-4 2.101E-2
1.763E-1
5.884E-1
 4 25
29 MP:0011107 embryonic lethality between somite formation and embryo turning, incomplete penetrance 2.780E-4 2.296E-2
1.926E-1
6.887E-1
 4 26
30 MP:0014069 abnormal skeletal muscle glycogen level 2.780E-4 2.296E-2
1.926E-1
6.887E-1
 4 26
31 MP:0010240 decreased skeletal muscle size 3.074E-4 2.456E-2
2.061E-1
7.614E-1
 6 74
32 MP:0009417 skeletal muscle atrophy 4.118E-4 3.187E-2
2.675E-1
1.000E0
 5 51
33 MP:0002269 muscular atrophy 4.571E-4 3.345E-2
2.807E-1
1.000E0
 7 111
34 MP:0000526 small inner medullary pyramid 4.591E-4 3.345E-2
2.807E-1
1.000E0
 2 3
35 MP:0003921 abnormal heart left ventricle morphology 5.121E-4 3.625E-2
3.042E-1
1.000E0
 12 313
36 MP:0014068 abnormal muscle glycogen level 5.577E-4 3.837E-2
3.220E-1
1.000E0
 4 31
37 MP:0002703 abnormal renal tubule morphology 6.028E-4 4.036E-2
3.387E-1
1.000E0
 11 274
38 MP:0006206 embryonic lethality between somite formation and embryo turning 6.278E-4 4.092E-2
3.434E-1
1.000E0
 7 117
39 MP:0009458 abnormal skeletal muscle size 7.349E-4 4.668E-2
3.917E-1
1.000E0
 6 87
Show 34 more annotations

6: Domain [Display Chart] 986 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00992 Troponin Pfam 8.376E-8 3.334E-5 2.491E-4 8.259E-5 4 6
2 IPR001978 Troponin InterPro 8.376E-8 3.334E-5 2.491E-4 8.259E-5 4 6
3 PF02736 Myosin N Pfam 1.353E-7 3.334E-5 2.491E-4 1.334E-4 5 15
4 IPR004009 Myosin N InterPro 1.353E-7 3.334E-5 2.491E-4 1.334E-4 5 15
5 IPR002928 Myosin tail InterPro 3.778E-7 6.209E-5 4.639E-4 3.725E-4 5 18
6 PF01576 Myosin tail 1 Pfam 3.778E-7 6.209E-5 4.639E-4 3.725E-4 5 18
7 4.10.270.10 - Gene3D 5.091E-7 6.275E-5 4.688E-4 5.020E-4 5 19
8 IPR027401 Myosin-like IQ dom InterPro 5.091E-7 6.275E-5 4.688E-4 5.020E-4 5 19
9 IPR027707 TNNT InterPro 6.587E-7 7.216E-5 5.391E-4 6.494E-4 3 3
10 SM00242 MYSc SMART 1.921E-5 1.457E-3 1.089E-2 1.895E-2 5 38
11 PS51456 MYOSIN MOTOR PROSITE 1.921E-5 1.457E-3 1.089E-2 1.895E-2 5 38
12 IPR001609 Myosin head motor dom InterPro 1.921E-5 1.457E-3 1.089E-2 1.895E-2 5 38
13 PF00063 Myosin head Pfam 1.921E-5 1.457E-3 1.089E-2 1.895E-2 5 38
14 SM00015 IQ SMART 7.748E-5 5.457E-3 4.077E-2
7.639E-2
 6 81
15 IPR000048 IQ motif EF-hand-BS InterPro 1.393E-4 9.158E-3
6.842E-2
1.374E-1
 6 90
16 PS50096 IQ PROSITE 1.669E-4 1.029E-2
7.686E-2
1.646E-1
 6 93
17 PF02234 CDI Pfam 2.272E-4 1.244E-2
9.297E-2
2.240E-1
 2 3
18 IPR003175 CDI InterPro 2.272E-4 1.244E-2
9.297E-2
2.240E-1
 2 3
19 PF00612 IQ Pfam 3.951E-4 1.591E-2
1.188E-1
3.895E-1
 5 71
20 PS51509 PHOSPHAGEN KINASE N PROSITE 4.517E-4 1.591E-2
1.188E-1
4.454E-1
 2 4
21 PS51510 PHOSPHAGEN KINASE C PROSITE 4.517E-4 1.591E-2
1.188E-1
4.454E-1
 2 4
22 PS00112 PHOSPHAGEN KINASE PROSITE 4.517E-4 1.591E-2
1.188E-1
4.454E-1
 2 4
23 IPR022414 ATP-guanido PTrfase cat InterPro 4.517E-4 1.591E-2
1.188E-1
4.454E-1
 2 4
24 IPR022413 ATP-guanido PTrfase N InterPro 4.517E-4 1.591E-2
1.188E-1
4.454E-1
 2 4
25 1.10.135.10 - Gene3D 4.517E-4 1.591E-2
1.188E-1
4.454E-1
 2 4
26 PF02807 ATP-gua PtransN Pfam 4.517E-4 1.591E-2
1.188E-1
4.454E-1
 2 4
27 PF00217 ATP-gua Ptrans Pfam 4.517E-4 1.591E-2
1.188E-1
4.454E-1
 2 4
28 IPR022415 ATP-guanido PTrfase AS InterPro 4.517E-4 1.591E-2
1.188E-1
4.454E-1
 2 4
29 IPR000749 ATP-guanido PTrfase InterPro 7.485E-4 2.545E-2
1.902E-1
7.381E-1
 2 5
30 PS50222 EF HAND 2 PROSITE 9.947E-4 3.145E-2
2.350E-1
9.808E-1
 8 231
31 IPR002048 EF hand dom InterPro 1.023E-3 3.145E-2
2.350E-1
1.000E0
 8 232
32 IPR031847 DUF4749 InterPro 1.116E-3 3.145E-2
2.350E-1
1.000E0
 2 6
33 PF15936 DUF4749 Pfam 1.116E-3 3.145E-2
2.350E-1
1.000E0
 2 6
34 3.30.590.10 - Gene3D 1.116E-3 3.145E-2
2.350E-1
1.000E0
 2 6
35 IPR014746 Gln synth/guanido kin cat dom InterPro 1.116E-3 3.145E-2
2.350E-1
1.000E0
 2 6
36 PF00595 PDZ Pfam 1.522E-3 4.168E-2
3.114E-1
1.000E0
 6 141
37 SM00228 PDZ SMART 1.946E-3 4.795E-2
3.583E-1
1.000E0
 6 148
38 PS00406 ACTINS 1 PROSITE 2.060E-3 4.795E-2
3.583E-1
1.000E0
 2 8
39 2.30.42.10 - Gene3D 2.082E-3 4.795E-2
3.583E-1
1.000E0
 6 150
40 1.10.238.10 - Gene3D 2.151E-3 4.795E-2
3.583E-1
1.000E0
 8 261
41 PS50106 PDZ PROSITE 2.153E-3 4.795E-2
3.583E-1
1.000E0
 6 151
42 IPR001478 PDZ InterPro 2.225E-3 4.795E-2
3.583E-1
1.000E0
 6 152
43 SM00054 EFh SMART 2.700E-3 4.795E-2
3.583E-1
1.000E0
 6 158
44 PF00412 LIM Pfam 3.145E-3 4.795E-2
3.583E-1
1.000E0
 4 69
45 IPR031127 E3 UB ligase RBR InterPro 3.273E-3 4.795E-2
3.583E-1
1.000E0
 2 10
46 IPR016039 Thiolase-like InterPro 3.273E-3 4.795E-2
3.583E-1
1.000E0
 2 10
47 3.40.47.10 - Gene3D 3.273E-3 4.795E-2
3.583E-1
1.000E0
 2 10
48 PF15040 Humanin Pfam 3.273E-3 4.795E-2
3.583E-1
1.000E0
 2 10
49 IPR002453 Beta tubulin InterPro 3.273E-3 4.795E-2
3.583E-1
1.000E0
 2 10
50 IPR028139 Humanin InterPro 3.273E-3 4.795E-2
3.583E-1
1.000E0
 2 10
Show 45 more annotations

7: Pathway [Display Chart] 874 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 198903 Striated Muscle Contraction BioSystems: WikiPathways 2.193E-21 1.917E-18 1.409E-17 1.917E-18 15 38
2 106262 Striated Muscle Contraction BioSystems: REACTOME 4.402E-19 1.924E-16 1.414E-15 3.847E-16 13 31
3 106261 Muscle contraction BioSystems: REACTOME 1.989E-17 5.795E-15 4.260E-14 1.739E-14 14 51
4 142269 superpathway of cholesterol biosynthesis BioSystems: BIOCYC 7.005E-11 1.531E-8 1.125E-7 6.122E-8 8 26
5 PW:0000454 cholesterol biosynthetic Pathway Ontology 1.696E-10 2.965E-8 2.180E-7 1.483E-7 7 18
6 SMP00023 Steroid Biosynthesis SMPDB 6.054E-10 8.819E-8 6.483E-7 5.292E-7 7 21
7 106142 Cholesterol biosynthesis BioSystems: REACTOME 8.811E-10 1.100E-7 8.087E-7 7.701E-7 7 22
8 198809 Cholesterol biosynthesis BioSystems: WikiPathways 7.350E-9 8.030E-7 5.903E-6 6.424E-6 6 17
9 SMP00111 Cerivastatin Pathway SMPDB 5.352E-8 2.462E-6 1.810E-5 4.678E-5 5 12
10 SMP00112 Risedronate Pathway SMPDB 5.352E-8 2.462E-6 1.810E-5 4.678E-5 5 12
11 SMP00107 Zoledronate Pathway SMPDB 5.352E-8 2.462E-6 1.810E-5 4.678E-5 5 12
12 SMP00131 Atorvastatin Pathway SMPDB 5.352E-8 2.462E-6 1.810E-5 4.678E-5 5 12
13 SMP00117 Pamidronate Pathway SMPDB 5.352E-8 2.462E-6 1.810E-5 4.678E-5 5 12
14 SMP00079 Ibandronate Pathway SMPDB 5.352E-8 2.462E-6 1.810E-5 4.678E-5 5 12
15 SMP00119 Fluvastatin Pathway SMPDB 5.352E-8 2.462E-6 1.810E-5 4.678E-5 5 12
16 SMP00089 Pravastatin Pathway SMPDB 5.352E-8 2.462E-6 1.810E-5 4.678E-5 5 12
17 SMP00092 Rosuvastatin Pathway SMPDB 5.352E-8 2.462E-6 1.810E-5 4.678E-5 5 12
18 SMP00099 Lovastatin Pathway SMPDB 5.352E-8 2.462E-6 1.810E-5 4.678E-5 5 12
19 SMP00095 Alendronate pathway SMPDB 5.352E-8 2.462E-6 1.810E-5 4.678E-5 5 12
20 142266 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) BioSystems: BIOCYC 8.632E-8 3.429E-6 2.521E-5 7.544E-5 5 13
21 142267 cholesterol biosynthesis I BioSystems: BIOCYC 8.632E-8 3.429E-6 2.521E-5 7.544E-5 5 13
22 142268 cholesterol biosynthesis III (via desmosterol) BioSystems: BIOCYC 8.632E-8 3.429E-6 2.521E-5 7.544E-5 5 13
23 P00016 Cytoskeletal regulation by Rho GTPase PantherDB 2.675E-7 1.017E-5 7.473E-5 2.338E-4 8 69
24 82937 Steroid biosynthesis BioSystems: KEGG 9.861E-7 3.591E-5 2.640E-4 8.619E-4 5 20
25 114229 Hypertrophic cardiomyopathy (HCM) BioSystems: KEGG 1.131E-6 3.953E-5 2.906E-4 9.883E-4 8 83
26 121494 Dilated cardiomyopathy BioSystems: KEGG 2.104E-6 7.071E-5 5.198E-4 1.839E-3 8 90
27 219802 SREBP signalling BioSystems: WikiPathways 2.313E-6 7.488E-5 5.504E-4 2.022E-3 7 64
28 P00014 Cholesterol biosynthesis PantherDB 2.437E-6 7.608E-5 5.593E-4 2.130E-3 4 11
29 83071 Tight junction BioSystems: KEGG 4.958E-6 1.494E-4 1.098E-3 4.333E-3 9 134
30 755438 SREBF and miR33 in cholesterol and lipid homeostasis BioSystems: WikiPathways 2.147E-5 6.255E-4 4.598E-3 1.876E-2 4 18
31 P00044 Nicotinic acetylcholine receptor signaling pathway PantherDB 2.443E-5 6.886E-4 5.062E-3 2.135E-2 7 91
32 685552 Activation of Gene Expression by SREBP (SREBF) BioSystems: REACTOME 3.598E-5 9.826E-4 7.223E-3 3.144E-2 5 40
33 576262 Extracellular matrix organization BioSystems: REACTOME 4.102E-5 1.086E-3 7.986E-3 3.585E-2 11 264
34 PW:0000248 steroid biosynthetic Pathway Ontology 6.769E-5 1.740E-3 1.279E-2
5.916E-2
 3 9
35 142287 epoxysqualene biosynthesis BioSystems: BIOCYC 8.990E-5 2.209E-3 1.624E-2
7.858E-2
 2 2
36 93344 Cardiac muscle contraction BioSystems: KEGG 9.537E-5 2.209E-3 1.624E-2
8.335E-2
 6 78
37 MAP00100 Sterol biosynthesis MAP00100 Sterol biosynthesis GenMAPP 9.604E-5 2.209E-3 1.624E-2
8.393E-2
 3 10
38 413387 C5 isoprenoid biosynthesis, mevalonate pathway BioSystems: KEGG 9.604E-5 2.209E-3 1.624E-2
8.393E-2
 3 10
39 413390 Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol BioSystems: KEGG 1.311E-4 2.865E-3 2.106E-2
1.146E-1
 3 11
40 142207 mevalonate pathway I BioSystems: BIOCYC 1.311E-4 2.865E-3 2.106E-2
1.146E-1
 3 11
41 685551 Regulation of Cholesterol Biosynthesis by SREBP (SREBF) BioSystems: REACTOME 1.422E-4 3.032E-3 2.229E-2
1.243E-1
 5 53
42 645304 Heparan sulfate/heparin (HS-GAG) metabolism BioSystems: REACTOME 1.556E-4 3.238E-3 2.380E-2
1.360E-1
 5 54
43 545288 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) BioSystems: BIOCYC 2.242E-4 4.523E-3 3.325E-2
1.959E-1
 3 13
44 198852 Statin Pathway BioSystems: WikiPathways 2.277E-4 4.523E-3 3.325E-2
1.990E-1
 4 32
45 685554 Translocation of GLUT4 to the Plasma Membrane BioSystems: REACTOME 2.997E-4 5.821E-3 4.279E-2
2.620E-1
 5 62
46 M2587 Stress Induction of HSP Regulation MSigDB C2 BIOCARTA (v5.1) 3.517E-4 6.683E-3 4.912E-2
3.074E-1
 3 15
47 198812 Endochondral Ossification BioSystems: WikiPathways 4.017E-4 7.470E-3
5.491E-2
3.511E-1
 5 66
48 P00031 Inflammation mediated by chemokine and cytokine signaling pathway PantherDB 4.662E-4 8.489E-3
6.240E-2
4.075E-1
 8 191
49 PW:0000184 terpenoid biosynthetic Pathway Ontology 5.327E-4 9.312E-3
6.845E-2
4.656E-1
 2 4
50 545319 creatine-phosphate biosynthesis BioSystems: BIOCYC 5.327E-4 9.312E-3
6.845E-2
4.656E-1
 2 4
Show 45 more annotations

8: Pubmed [Display Chart] 24830 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18660489:gr Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. GeneRIF 1.786E-12 2.217E-8 2.371E-7 4.434E-8 13 250
2 18660489 Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. Pubmed 1.786E-12 2.217E-8 2.371E-7 4.434E-8 13 250
3 20357587:gr Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot. GeneRIF 9.646E-11 5.987E-7 6.405E-6 2.395E-6 4 4
4 20357587 Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot. Pubmed 9.646E-11 5.987E-7 6.405E-6 2.395E-6 4 4
5 9724539 A recombinant monocysteine mutant (Ser to Cys-155) of fast skeletal troponin T: identification by cross-linking of a domain involved in a physiologically relevant interaction with troponins C and I. Pubmed 4.811E-10 2.389E-6 2.556E-5 1.195E-5 4 5
6 20301486 Dilated Cardiomyopathy Overview Pubmed 7.728E-10 3.198E-6 3.421E-5 1.919E-5 6 32
7 8987992 Interaction of deletion mutants of troponins I and T: COOH-terminal truncation of troponin T abolishes troponin I binding and reduces Ca2+ sensitivity of the reconstituted regulatory system. Pubmed 1.440E-9 5.107E-6 5.463E-5 3.575E-5 4 6
8 18157088 Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2. Pubmed 5.052E-9 1.568E-5 1.677E-4 1.254E-4 6 43
9 20301725 Hypertrophic Cardiomyopathy Overview Pubmed 7.505E-9 2.070E-5 2.215E-4 1.863E-4 5 22
10 15967462 MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination. Pubmed 1.503E-8 3.731E-5 3.991E-4 3.731E-4 5 25
11 20301465 Nemaline Myopathy Pubmed 1.996E-8 4.130E-5 4.417E-4 4.955E-4 4 10
12 1907279 Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus. Pubmed 1.996E-8 4.130E-5 4.417E-4 4.955E-4 4 10
13 21470888 The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes. Pubmed 3.106E-8 4.821E-5 5.157E-4 7.713E-4 3 3
14 26774798 TNNT1, TNNT2, and TNNT3: Isoform genes, regulation, and structure-function relationships. Pubmed 3.106E-8 4.821E-5 5.157E-4 7.713E-4 3 3
15 1691980 Identification of three developmentally controlled isoforms of human myosin heavy chains. Pubmed 3.106E-8 4.821E-5 5.157E-4 7.713E-4 3 3
16 21470888:gr The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes. GeneRIF 3.106E-8 4.821E-5 5.157E-4 7.713E-4 3 3
17 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 4.634E-8 6.393E-5 6.838E-4 1.151E-3 11 383
18 19453261:gr High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. GeneRIF 4.634E-8 6.393E-5 6.838E-4 1.151E-3 11 383
19 20301299 Thoracic Aortic Aneurysms and Aortic Dissections Pubmed 6.745E-8 8.374E-5 8.957E-4 1.675E-3 4 13
20 18513529 Relationship between sex, shape, and substrate in hypertrophic cardiomyopathy. Pubmed 6.745E-8 8.374E-5 8.957E-4 1.675E-3 4 13
21 20634891:gr Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. GeneRIF 1.207E-7 1.184E-4 1.266E-3 2.998E-3 10 331
22 20634891 Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Pubmed 1.207E-7 1.184E-4 1.266E-3 2.998E-3 10 331
23 15542288 Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. Pubmed 1.240E-7 1.184E-4 1.266E-3 3.078E-3 3 4
24 25892673 Targeted next-generation sequencing (NGS) of nine candidate genes with custom AmpliSeq in patients and a cardiomyopathy risk group. Pubmed 1.240E-7 1.184E-4 1.266E-3 3.078E-3 3 4
25 18032382 A troponin T mutation that causes infantile restrictive cardiomyopathy increases Ca2+ sensitivity of force development and impairs the inhibitory properties of troponin. Pubmed 1.240E-7 1.184E-4 1.266E-3 3.078E-3 3 4
26 9501083 Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin. Pubmed 1.240E-7 1.184E-4 1.266E-3 3.078E-3 3 4
27 17855807 Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery. Pubmed 1.704E-7 1.511E-4 1.617E-3 4.232E-3 4 16
28 17855807:gr Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery. GeneRIF 1.704E-7 1.511E-4 1.617E-3 4.232E-3 4 16
29 17266347 Proteome-wide Identification of HtrA2/Omi Substrates. Pubmed 2.223E-7 1.903E-4 2.036E-3 5.520E-3 4 17
30 25670202 Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. Pubmed 3.027E-7 2.020E-4 2.161E-3 7.515E-3 6 84
31 11904166 The interaction of the bisphosphorylated N-terminal arm of cardiac troponin I-A 31P-NMR study. Pubmed 3.092E-7 2.020E-4 2.161E-3 7.677E-3 3 5
32 16902413 Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo. Pubmed 3.092E-7 2.020E-4 2.161E-3 7.677E-3 3 5
33 22349865:gr Clinical, pathological, and genetic mutation analysis of sporadic inclusion body myositis in Japanese people. GeneRIF 3.092E-7 2.020E-4 2.161E-3 7.677E-3 3 5
34 9560191 Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution. Pubmed 3.092E-7 2.020E-4 2.161E-3 7.677E-3 3 5
35 11707283 Interaction of ADP-ribosylated actin with actin binding proteins. Pubmed 3.092E-7 2.020E-4 2.161E-3 7.677E-3 3 5
36 22349865 Clinical, pathological, and genetic mutation analysis of sporadic inclusion body myositis in Japanese people. Pubmed 3.092E-7 2.020E-4 2.161E-3 7.677E-3 3 5
37 17194691 Mutations in fast skeletal troponin I, troponin T, and beta-tropomyosin that cause distal arthrogryposis all increase contractile function. Pubmed 3.092E-7 2.020E-4 2.161E-3 7.677E-3 3 5
38 21536590:gr Deficiency of ¿-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling. GeneRIF 3.092E-7 2.020E-4 2.161E-3 7.677E-3 3 5
39 20474083 A novel custom resequencing array for dilated cardiomyopathy. Pubmed 3.603E-7 2.236E-4 2.392E-3 8.945E-3 4 19
40 20474083:gr A novel custom resequencing array for dilated cardiomyopathy. GeneRIF 3.603E-7 2.236E-4 2.392E-3 8.945E-3 4 19
41 19019082 Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes. Pubmed 5.072E-7 3.072E-4 3.286E-3 1.259E-2 5 49
42 20201937:gr Common susceptibility variants examined for association with dilated cardiomyopathy. GeneRIF 6.169E-7 3.482E-4 3.724E-3 1.532E-2 3 6
43 12432079 Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2. Pubmed 6.169E-7 3.482E-4 3.724E-3 1.532E-2 3 6
44 20201937 Common susceptibility variants examined for association with dilated cardiomyopathy. Pubmed 6.169E-7 3.482E-4 3.724E-3 1.532E-2 3 6
45 16526095 Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression. Pubmed 6.749E-7 3.724E-4 3.983E-3 1.676E-2 4 22
46 25852190 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Pubmed 6.974E-7 3.764E-4 4.027E-3 1.732E-2 10 401
47 8889549 Generation and analysis of 280,000 human expressed sequence tags. Pubmed 9.752E-7 5.152E-4 5.511E-3 2.421E-2 9 321
48 23788249 ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Pubmed 1.091E-6 5.645E-4 6.038E-3 2.710E-2 5 57
49 8681137 Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization. Pubmed 2.154E-6 1.091E-3 1.167E-2
5.348E-2
 4 29
50 26871637 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Pubmed 3.401E-6 1.679E-3 1.796E-2
8.445E-2
 9 374
Show 45 more annotations

9: Interaction [Display Chart] 3421 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:TRIM63 TRIM63 interactions 2.532E-14 8.661E-11 7.548E-10 8.661E-11 15 99
2 int:TNNI1 TNNI1 interactions 1.249E-12 2.136E-9 1.862E-8 4.273E-9 8 17
3 int:FBXO32 FBXO32 interactions 2.265E-10 2.582E-7 2.251E-6 7.747E-7 14 154
4 int:TPM1 TPM1 interactions 9.351E-10 7.998E-7 6.970E-6 3.199E-6 12 115
5 int:ACTN2 ACTN2 interactions 4.161E-9 2.847E-6 2.481E-5 1.423E-5 10 80
6 int:KCNMA1 KCNMA1 interactions 2.120E-7 1.209E-4 1.053E-3 7.253E-4 12 186
7 int:TMEM260 TMEM260 interactions 5.318E-7 2.599E-4 2.265E-3 1.819E-3 4 8
8 int:TNNI3 TNNI3 interactions 7.564E-7 3.234E-4 2.819E-3 2.587E-3 5 19
9 int:FHL2 FHL2 interactions 3.871E-6 1.471E-3 1.282E-2 1.324E-2 9 129
10 int:TNNC1 TNNC1 interactions 5.234E-6 1.777E-3 1.549E-2 1.790E-2 4 13
11 int:PKM PKM interactions 6.686E-6 1.777E-3 1.549E-2 2.287E-2 10 175
12 int:MYH3 MYH3 interactions 7.273E-6 1.777E-3 1.549E-2 2.488E-2 4 14
13 int:MYL1 MYL1 interactions 7.273E-6 1.777E-3 1.549E-2 2.488E-2 4 14
14 int:TNNI2 TNNI2 interactions 7.273E-6 1.777E-3 1.549E-2 2.488E-2 4 14
15 int:TPM2 TPM2 interactions 1.175E-5 2.514E-3 2.191E-2 4.020E-2 7 81
16 int:AKT1 AKT1 interactions 1.293E-5 2.514E-3 2.191E-2 4.423E-2 13 323
17 int:TAGLN TAGLN interactions 1.315E-5 2.514E-3 2.191E-2 4.499E-2 6 55
18 int:ACTN1 ACTN1 interactions 1.323E-5 2.514E-3 2.191E-2 4.526E-2 9 150
19 int:MYOD1 MYOD1 interactions 4.362E-5 7.854E-3
6.845E-2
1.492E-1
 7 99
20 int:MYH8 MYH8 interactions 6.766E-5 1.157E-2
1.009E-1
2.315E-1
 3 9
21 int:CDCA8 CDCA8 interactions 7.251E-5 1.181E-2
1.029E-1
2.481E-1
 5 46
22 int:MYH1 MYH1 interactions 8.472E-5 1.317E-2
1.148E-1
2.898E-1
 4 25
23 int:ACTA1 ACTA1 interactions 1.035E-4 1.539E-2
1.341E-1
3.539E-1
 9 195
24 int:TNNT2 TNNT2 interactions 1.311E-4 1.868E-2
1.628E-1
4.483E-1
 3 11
25 int:HSPE1 HSPE1 interactions 1.476E-4 2.020E-2
1.761E-1
5.051E-1
 7 120
26 int:ACTN4 ACTN4 interactions 1.722E-4 2.265E-2
1.974E-1
5.889E-1
 7 123
27 int:YWHAE YWHAE interactions 2.105E-4 2.667E-2
2.325E-1
7.202E-1
 14 483
28 int:MAP1A MAP1A interactions 2.583E-4 3.027E-2
2.638E-1
8.838E-1
 4 33
29 int:TCTA TCTA interactions 2.671E-4 3.027E-2
2.638E-1
9.138E-1
 2 3
30 int:TTN TTN interactions 2.807E-4 3.027E-2
2.638E-1
9.602E-1
 5 61
31 int:CNN1 CNN1 interactions 2.831E-4 3.027E-2
2.638E-1
9.686E-1
 3 14
32 int:ROGDI ROGDI interactions 2.831E-4 3.027E-2
2.638E-1
9.686E-1
 3 14
33 int:HSPB2 HSPB2 interactions 3.607E-4 3.740E-2
3.259E-1
1.000E0
 6 99
34 int:EEF2 EEF2 interactions 4.051E-4 4.025E-2
3.508E-1
1.000E0
 8 186
35 int:MYPN MYPN interactions 4.295E-4 4.025E-2
3.508E-1
1.000E0
 3 16
36 int:HTRA2 HTRA2 interactions 4.353E-4 4.025E-2
3.508E-1
1.000E0
 5 67
37 int:TRAF3IP1 TRAF3IP1 interactions 4.353E-4 4.025E-2
3.508E-1
1.000E0
 5 67
38 int:ATXN2L ATXN2L interactions 4.492E-4 4.044E-2
3.524E-1
1.000E0
 4 38
39 int:ALDOC ALDOC interactions 5.332E-4 4.677E-2
4.076E-1
1.000E0
 5 70
Show 34 more annotations

10: Cytoband [Display Chart] 147 annotations before applied cutoff / 34661 genes in category

No results to display

11: Transcription Factor Binding Site [Display Chart] 478 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$MEF2 02 V$MEF2 02 2.356E-7 1.126E-4 7.599E-4 1.126E-4 13 197
2 CTAWWWATA V$RSRFC4 Q2 CTAWWWATA V$RSRFC4 Q2 8.788E-7 2.100E-4 1.417E-3 4.201E-4 15 298
3 TAAWWATAG V$RSRFC4 Q2 TAAWWATAG V$RSRFC4 Q2 1.534E-5 2.444E-3 1.649E-2 7.332E-3 9 133
4 V$HMEF2 Q6 V$HMEF2 Q6 5.181E-5 5.225E-3 3.526E-2 2.477E-2 8 120
5 V$MEF2 03 V$MEF2 03 6.427E-5 5.225E-3 3.526E-2 3.072E-2 10 198
6 V$MEF2 01 V$MEF2 01 6.930E-5 5.225E-3 3.526E-2 3.312E-2 8 125
7 V$MEF2 Q6 01 V$MEF2 Q6 01 9.706E-5 5.225E-3 3.526E-2 4.640E-2 10 208
8 V$RSRFC4 01 V$RSRFC4 01 9.706E-5 5.225E-3 3.526E-2 4.640E-2 10 208
9 V$AMEF2 Q6 V$AMEF2 Q6 1.093E-4 5.225E-3 3.526E-2
5.225E-2
 10 211
10 V$SRF Q6 V$SRF Q6 1.093E-4 5.225E-3 3.526E-2
5.225E-2
 10 211
11 V$RSRFC4 Q2 V$RSRFC4 Q2 1.778E-4 7.725E-3
5.213E-2
8.497E-2
 9 182
12 V$AP4 Q6 01 V$AP4 Q6 01 4.782E-4 1.905E-2
1.285E-1
2.286E-1
 9 208
13 V$E2A Q2 V$E2A Q2 1.309E-3 4.454E-2
3.006E-1
6.256E-1
 8 193
14 CCAWWNAAGG V$SRF Q4 CCAWWNAAGG V$SRF Q4 1.323E-3 4.454E-2
3.006E-1
6.322E-1
 5 74
15 V$MYOD Q6 01 V$MYOD Q6 01 1.398E-3 4.454E-2
3.006E-1
6.682E-1
 8 195
16 V$MYOD Q6 V$MYOD Q6 1.642E-3 4.677E-2
3.156E-1
7.848E-1
 8 200
17 V$TATA C V$TATA C 1.663E-3 4.677E-2
3.156E-1
7.950E-1
 9 248
Show 12 more annotations

12: Gene Family [Display Chart] 82 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1219 EF-hand domain containing|Troponin complex subunits genenames.org 7.423E-13 6.087E-11 3.037E-10 6.087E-11 6 8
2 1098 Myosin heavy chains genenames.org 1.441E-8 5.907E-7 2.948E-6 1.181E-6 5 15
3 657 Myosin light chains|EF-hand domain containing genenames.org 5.954E-5 1.627E-3 8.121E-3 4.882E-3 3 14
4 1220 PDZ domain containing genenames.org 2.144E-4 3.827E-3 1.910E-2 1.758E-2 6 152
5 863 EF-hand domain containing genenames.org 2.333E-4 3.827E-3 1.910E-2 1.913E-2 7 219
6 1218 LIM domain containing genenames.org 3.345E-4 4.571E-3 2.281E-2 2.742E-2 4 59
7 929 Actins genenames.org 4.601E-4 5.389E-3 2.689E-2 3.772E-2 2 6
8 1160 CD molecules|Integrin alpha subunits genenames.org 4.491E-3 4.603E-2
2.297E-1
3.683E-1
 2 18
Show 3 more annotations

13: Coexpression [Display Chart] 6230 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5909 Genes involved in development of skeletal muscle (myogenesis). MSigDB H: Hallmark Gene Sets (v5.1) 2.867E-35 1.786E-31 1.664E-30 1.786E-31 33 200
2 M16123 Muscle development genes up-regulated in Rh4 cells (alveolar rhabdomyosarcoma, ARMS) but not in the RD cells (embryonal rhabdomyosarcoma, ERMS) after knockdown of PAX3-FOXO1 [GeneID=5077;2308] fusion by RNAi for 72 hr. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.529E-30 7.876E-27 7.336E-26 1.575E-26 20 50
3 M78 Genes up-regulated in Rh4 cells (alveolar rhabdomyosarcoma, ARMS) after knockdown of the PAX3-FOXO1 [GeneiD=5077;2308] fusion protein by RNAi for 72 hr. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.148E-29 1.465E-25 1.364E-24 4.453E-25 29 207
4 M9065 Genes up-regulated in C2AS12 cells (myoblast) by IGF1 [GeneID=3479] vs PDGFB [GeneID=5155]. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.405E-29 1.465E-25 1.364E-24 5.860E-25 22 82
5 M2043 Cluster f: genes identifying an intrinsic group in head and neck squamous cell carcinoma (HNSCC). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.468E-27 1.830E-24 1.704E-23 9.149E-24 19 54
6 M3001 Genes up-regulated in type 1 (soleus) vs type 2B (EDL) myofibers. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.465E-19 1.521E-16 1.417E-15 9.127E-16 13 35
7 M1624 Genes up-regulated in NIH 3T3 cells (fibroblasts) 24 h after inducing MYOD [GeneID=4654] which were down-regulated by dominant negative form of SMARCA4 [GeneID=6597]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.755E-18 2.452E-15 2.284E-14 1.716E-14 9 11
8 M1557 Genes up-regulated in NIH 3T3 cells (fibroblasts) 24 h after inducing MyoD [GeneID=4654] differentiation program. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.245E-16 9.693E-14 9.029E-13 7.755E-13 15 89
9 M2293 Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.707E-15 1.181E-12 1.100E-11 1.063E-11 22 315
10 M5924 Genes up-regulated through activation of mTORC1 complex. MSigDB H: Hallmark Gene Sets (v5.1) 1.342E-13 8.358E-11 7.785E-10 8.358E-10 17 200
11 M768 Genes commonly up-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.583E-13 2.029E-10 1.890E-9 2.232E-9 13 98
12 M2383 Genes up-regulated in E12.5 forelimb buds with POR [GeneID=5447] knockout. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.012E-11 5.253E-9 4.893E-8 6.304E-8 8 26
13 M5892 Genes involved in cholesterol homeostasis. MSigDB H: Hallmark Gene Sets (v5.1) 1.693E-10 8.115E-8 7.558E-7 1.055E-6 10 74
14 M7396 Genes down-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.557E-10 2.473E-7 2.304E-6 3.462E-6 19 435
15 M1466 Genes up-regulated in MEF cells (embryonic fibroblast) expressing ~25% of YY1 [GeneID=7528]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.865E-10 2.851E-7 2.656E-6 4.277E-6 14 214
16 M1123 Genes down-regulated in benign skin tumors (papilloma) induced by treatment with DMBA and TPA [PubChem=6001;4792] chemicals in the two stage skin carcinogenesis model. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.503E-9 9.747E-7 9.079E-6 1.560E-5 6 18
17 M1459 Genes up-regulated in BEC (blood endothelial cells) compared to LEC (lymphatic endothelial cells). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.914E-9 1.068E-6 9.948E-6 1.816E-5 12 162
18 M9331 Genes down-regulated in mouse stroma of pancreatic adenocarcinoma zenografts after treatment with HhAntag, a hedgehog (Hh) pathway inhibitor. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.029E-8 3.562E-6 3.318E-5 6.412E-5 14 264
19 M12004 Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of both HDAC1 and HDAC2 [GeneID=3065;3066] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.748E-8 5.731E-6 5.338E-5 1.089E-4 13 231
20 M3009 Genes up-regulated in liver from mice transgenic for SREBF1 or SREBF2 [GeneID = 6720, 6721] and down-regulated in mice lacking SCAP [GeneID=22937]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.288E-8 6.789E-6 6.324E-5 1.426E-4 6 25
21 M2307 Representative genes up-regulated in C2C12 cells (myoblast) lacking NFkB activity due to expression of a super repressor form of NFKBIA [GeneID=4792]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.288E-8 6.789E-6 6.324E-5 1.426E-4 6 25
22 M4001 Genes down-regulated in RD cells (embryonal rhabdomyosarcoma, ERMS) by expression of PAX3- or PAX7-FOXO1 [GeneID=5077;5081;2308] fusions off retroviral vectors. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.685E-8 1.044E-5 9.720E-5 2.296E-4 8 68
23 M2434 Transcripts dependent upon IRS1 and IRS2 [GeneID=3667, 8660] for normal expression in liver. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.568E-8 1.237E-5 1.152E-4 2.846E-4 9 98
24 M5793 Down-regulated genes in the canonical gene expression signature of the fibroblast core serum response (CSR) defined by the Stanford group. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.067E-8 1.315E-5 1.225E-4 3.157E-4 12 209
25 M2571 Genes down-regulated during prostate cancer progression in the JOCK1 model due to inducible activation of FGFR1 [GeneID=2260] gene in prostate. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.098E-8 1.769E-5 1.648E-4 4.422E-4 14 308
26 M4913 Genes down-regulated in adipose tissue mesenchymal stem cells (ASC) vs bone marrow mesenchymal stem cells (rBMSC) MSigDB C2: CGP Curated Gene Sets (v5.1) 1.066E-7 2.555E-5 2.380E-4 6.643E-4 9 108
27 M10427 Up-regulated in brown preadipocytes with IRS1 [GeneID=3667] knockout vs wild type controls; the knockouts have severe defects in adipocyte differentiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.577E-7 3.587E-5 3.341E-4 9.827E-4 9 113
28 M1127 Genes down-regulated in malignant skin tumors (squamous cell carcinoma, SCC) formed by treatment with DMBA and TPA [PubChem=6001;4792] in the two stage skin carcinogenesis model. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.612E-7 3.587E-5 3.341E-4 1.004E-3 5 18
29 M18058 Genes up-regulated in primary cultures of ovarian surface epithlium cells exposed to progesterone [PubChem=5994] for 5 days. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.935E-7 4.156E-5 3.871E-4 1.205E-3 10 152
30 GSE19923 E2A KO VS HEB AND E2A KO DP THYMOCYTE UP Genes up-regulated in double positive thymocytes: TCF3 [GeneID=6929] knockout versus TCF12 [GeneID=6938] knockout. MSigDB C7: Immunologic Signatures (v5.1) 2.868E-7 5.793E-5 5.396E-4 1.787E-3 11 200
31 M1611 Genes up-regulated in liver from transgenic mice with reduced expression of POR [GeneID=5447] in all tissues. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.883E-7 5.793E-5 5.396E-4 1.796E-3 5 20
32 M1618 Genes up-regulated in SW-13 cells (kidney cancer) by transient expression of SMARCA4 [GeneID=6597] at 24 h off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.495E-7 8.750E-5 8.150E-4 2.800E-3 7 64
33 M1647 Genes up-regulated in liver from mice with liver specific knockout of POR [GeneID=5447]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.271E-7 9.952E-5 9.270E-4 3.284E-3 6 41
34 M5103 Genes specifically expressed in FAB subtypes M2, M4, M5 and M7 of pediatric AML (acute myeloid leukemia). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.582E-6 2.899E-4 2.701E-3 9.858E-3 10 191
35 M1918 Up-regulated genes in pediatric adrenocortical tumors (ACT) compared to the normal tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.887E-6 3.358E-4 3.128E-3 1.175E-2 12 293
36 M11189 IRF4 [GeneID=3662] target genes induced after activation of primary B lymphocytes by anti-IgM crosslinking. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.266E-6 3.732E-4 3.476E-3 1.412E-2 7 81
37 GSE27670 CTRL VS BLIMP1 TRANSDUCED GC BCELL DN Genes down-regulated in germinal center B lymphocytes: control versus over-expressing PRDM1 [GeneID=639]. MSigDB C7: Immunologic Signatures (v5.1) 2.396E-6 3.732E-4 3.476E-3 1.493E-2 10 200
38 GSE21360 NAIVE VS TERTIARY MEMORY CD8 TCELL DN Genes down-regulated in CD8 T cells: naïve versus 3' memory. MSigDB C7: Immunologic Signatures (v5.1) 2.396E-6 3.732E-4 3.476E-3 1.493E-2 10 200
39 M5891 Genes up-regulated in response to low oxygen levels (hypoxia). MSigDB H: Hallmark Gene Sets (v5.1) 2.396E-6 3.732E-4 3.476E-3 1.493E-2 10 200
40 GSE22196 HEALTHY VS OBESE MOUSE SKIN GAMMADELTA TCELL DN Genes down-regulated in skin gamma delta T cells: healthy versus obesity. MSigDB C7: Immunologic Signatures (v5.1) 2.396E-6 3.732E-4 3.476E-3 1.493E-2 10 200
41 M15472 Down-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.358E-6 5.102E-4 4.753E-3 2.092E-2 13 366
42 M17143 Genes down-regulated in primary granulosa cells after stimulation with LH or FSH gonadotrophic hormones for 24 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.669E-6 5.443E-4 5.070E-3 2.286E-2 7 87
43 M2659 Genes down-regulated in late serum response of CRL 2091 cells (foreskin fibroblasts). MSigDB C6: Oncogenic Signatures (v5.1) 4.645E-6 6.576E-4 6.125E-3 2.894E-2 9 169
44 M1124 Pubertal genes up-regulated by TGFB1 [GeneID=7040]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.645E-6 6.576E-4 6.125E-3 2.894E-2 9 169
45 M2672 Genes up-regulated by everolimus [PubChem = 6442177] in prostate tissue. MSigDB C6: Oncogenic Signatures (v5.1) 4.874E-6 6.747E-4 6.285E-3 3.036E-2 9 170
46 M1461 Genes up-regulated in LEC (lymphatic endothelial cells) compared to BEC (blood endothelial cells). MSigDB C2: CGP Curated Gene Sets (v5.1) 5.829E-6 7.894E-4 7.353E-3 3.631E-2 8 131
47 M6906 Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC2 [GeneID=3066] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.166E-6 8.174E-4 7.613E-3 3.842E-2 8 132
48 M8876 Down-regulated genes in MM1.S cells (multiple myeloma) treated with adaphostin [PubChem=387042], a tyrosine kinase inhibitor with anticancer properties. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.993E-6 1.037E-3 9.663E-3 4.980E-2 4 18
49 M1492 Genes that are rapidly down-regulated as multipotential cells of the FDCP-mix hematopoiesis model undergo differentiation and loose their self-renewal and proliferation properties. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.152E-6 1.156E-3 1.077E-2
5.702E-2
 6 66
50 M1170 Selected genes down-regulated during progression through benign to malignant skin tumors formed by treatment with DMBA and TPA [PubChem=6001;4792] chemicals in the two stage skin carcinogenesis model. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.280E-6 1.156E-3 1.077E-2
5.781E-2
 7 100
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 3029 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 500 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.603E-21 1.697E-17 1.458E-16 1.697E-17 30 406
2 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 200 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.863E-20 8.880E-17 7.631E-16 1.776E-16 21 162
3 gudmap developingLowerUrinaryTract P1 bladder B 200 k2 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.120E-18 1.131E-15 9.718E-15 3.393E-15 14 50
4 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 500 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.865E-18 2.169E-15 1.864E-14 8.678E-15 27 388
5 BM Top 100 - skeletal muscle BM Top 100 - skeletal muscle Body Map 1.642E-17 9.946E-15 8.547E-14 4.973E-14 15 75
6 gudmap developingLowerUrinaryTract P1 bladder J 1000 k2 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.792E-17 1.643E-14 1.412E-13 1.148E-13 22 251
7 gudmap developingLowerUrinaryTract P1 bladder B 1000 k1 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.796E-17 1.643E-14 1.412E-13 1.150E-13 20 192
8 gudmap developingLowerUrinaryTract P1 bladder J 500 k4 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.837E-15 1.074E-12 9.229E-12 8.592E-12 15 104
9 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 1000 k1 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.778E-15 1.272E-12 1.093E-11 1.144E-11 20 243
10 gudmap developingLowerUrinaryTract P1 bladder J 200 k5 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#5 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.686E-15 1.722E-12 1.480E-11 1.722E-11 13 69
11 gudmap developingLowerUrinaryTract P1 bladder B 100 k3 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#3 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 6.646E-15 1.830E-12 1.573E-11 2.013E-11 10 28
12 gudmap developingLowerUrinaryTract P1 bladder B 500 k2 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.325E-14 3.345E-12 2.874E-11 4.014E-11 15 115
13 gudmap developingLowerUrinaryTract P1 bladder 500 J DevelopingLowerUrinaryTract P1 bladder J emap-30374 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.847E-14 8.704E-12 7.479E-11 1.165E-10 23 390
14 BM Top 100 - tongue superior part w papillae BM Top 100 - tongue superior part w papillae Body Map 4.310E-14 8.704E-12 7.479E-11 1.306E-10 13 80
15 BM Top 100 - tongue main corpus BM Top 100 - tongue main corpus Body Map 4.310E-14 8.704E-12 7.479E-11 1.306E-10 13 80
16 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 1000 k2 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 9.961E-14 1.886E-11 1.621E-10 3.017E-10 14 107
17 gudmap developingLowerUrinaryTract P1 bladder 200 J DevelopingLowerUrinaryTract P1 bladder J emap-30374 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.435E-13 2.556E-11 2.197E-10 4.346E-10 16 162
18 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 200 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.740E-13 2.927E-11 2.516E-10 5.269E-10 16 164
19 gudmap developingLowerUrinaryTract P1 bladder J 100 k4 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#4 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 2.183E-13 3.481E-11 2.991E-10 6.614E-10 9 26
20 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 200 k5 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#5 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.439E-13 3.694E-11 3.174E-10 7.387E-10 8 17
21 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 500 k3 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.765E-13 3.988E-11 3.427E-10 8.375E-10 14 115
22 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 100 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.144E-12 1.575E-10 1.353E-9 3.464E-9 12 80
23 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 500 k5 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.313E-12 3.035E-10 2.608E-9 7.005E-9 10 47
24 gudmap developingLowerUrinaryTract P1 bladder 500 B DevelopingLowerUrinaryTract P1 bladder B emap-30374 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.405E-12 3.035E-10 2.608E-9 7.284E-9 21 385
25 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k3 1000 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.086E-12 3.739E-10 3.213E-9 9.347E-9 11 66
26 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 100 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 3.697E-12 4.307E-10 3.701E-9 1.120E-8 12 88
27 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 5.195E-12 5.786E-10 4.972E-9 1.574E-8 23 494
28 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 100 k4 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#4 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 5.349E-12 5.786E-10 4.972E-9 1.620E-8 6 8
29 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 500 k2 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 8.199E-12 8.563E-10 7.359E-9 2.483E-8 17 246
30 gudmap developingLowerUrinaryTract P1 ureter 1000 k2 DevelopingLowerUrinaryTract P1 ureter emap-30363 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.398E-11 1.412E-9 1.213E-8 4.236E-8 15 184
31 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 100 k3 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#3 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.594E-11 1.558E-9 1.339E-8 4.829E-8 6 9
32 PCBC ctl geo-heart 100 geo heart top-relative-expression-ranked 100 PCBC 1.746E-11 1.653E-9 1.421E-8 5.290E-8 12 100
33 BM Top 100 - heart atrium BM Top 100 - heart atrium Body Map 2.382E-11 2.187E-9 1.879E-8 7.216E-8 11 79
34 gudmap developingLowerUrinaryTract P1 bladder 200 B DevelopingLowerUrinaryTract P1 bladder B emap-30374 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.654E-11 2.364E-9 2.032E-8 8.038E-8 14 160
35 gudmap developingLowerUrinaryTract P2 bladder stroma (LCM) 1000 k3 DevelopingLowerUrinaryTract P2 bladder stroma (LCM) emap-30396 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.947E-11 2.550E-9 2.191E-8 8.926E-8 16 229
36 gudmap developingGonad P2 epididymis 1000 k2 DevelopingGonad P2 epididymis emap-30199 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.146E-11 2.647E-9 2.275E-8 9.530E-8 16 230
37 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 k2 1000 dev lower uro neuro e14.5 PelvicGanglion Sox10 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 5.135E-11 4.204E-9 3.613E-8 1.556E-7 10 63
38 gudmap developingLowerUrinaryTract P1 bladder 100 J DevelopingLowerUrinaryTract P1 bladder J emap-30374 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 6.157E-11 4.908E-9 4.217E-8 1.865E-7 11 86
39 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k3 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.234E-10 9.583E-9 8.235E-8 3.737E-7 9 49
40 gudmap developingLowerUrinaryTract e14.5 urethra 1000 k1 DevelopingLowerUrinaryTract e14.5 urethra emap-30892 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.300E-10 9.789E-9 8.412E-8 3.938E-7 11 92
41 geo heart 1000 K5 geo heart top-relative-expression-ranked 1000 k-means-cluster#5 PCBC 1.325E-10 9.789E-9 8.412E-8 4.013E-7 20 428
42 fetal quiescent Top 500 All fetal quiescent Top 500 All Brain Map - Barres 2.085E-10 1.504E-8 1.292E-7 6.316E-7 21 489
43 PCBC ctl geo-heart 500 geo heart top-relative-expression-ranked 500 PCBC 3.015E-10 2.124E-8 1.825E-7 9.131E-7 21 499
44 80Dn Top 500 Cluster 2 80Dn Top 500 Cluster 2 Brain Map - Allen iN 3.511E-10 2.417E-8 2.077E-7 1.063E-6 15 231
45 gudmap developingLowerUrinaryTract e14.5 bladder 1000 k4 DevelopingLowerUrinaryTract e14.5 bladder emap-30872 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.693E-10 3.159E-8 2.715E-7 1.422E-6 12 132
46 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.787E-10 4.469E-8 3.840E-7 2.056E-6 18 372
47 gudmap developingLowerUrinaryTract P1 bladder 100 B DevelopingLowerUrinaryTract P1 bladder B emap-30374 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 8.564E-10 5.519E-8 4.743E-7 2.594E-6 10 83
48 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 k3 500 dev lower uro neuro e14.5 PelvicGanglion Sox10 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.490E-9 9.403E-8 8.080E-7 4.513E-6 8 44
49 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 500 dev lower uro neuro e14.5 PelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.404E-9 2.104E-7 1.808E-6 1.031E-5 19 463
50 BM Top 100 - heart ventricle BM Top 100 - heart ventricle Body Map 3.870E-9 2.344E-7 2.015E-6 1.172E-5 9 71
Show 45 more annotations

15: Computational [Display Chart] 393 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GNF2 TTN Neighborhood of TTN MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.980E-16 7.783E-14 5.099E-13 7.783E-14 12 26
2 module 202 Genes in module 202 MSigDb: C4 - CM: Cancer Modules 6.738E-11 1.324E-8 8.675E-8 2.648E-8 9 28
3 module 512 Genes in module 512 MSigDb: C4 - CM: Cancer Modules 1.095E-9 1.205E-7 7.895E-7 4.302E-7 9 37
4 module 329 Genes in module 329 MSigDb: C4 - CM: Cancer Modules 1.226E-9 1.205E-7 7.895E-7 4.819E-7 10 51
5 module 387 Genes in module 387 MSigDb: C4 - CM: Cancer Modules 1.575E-8 1.238E-6 8.113E-6 6.191E-6 9 49
6 GNF2 MYL2 Neighborhood of MYL2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.869E-7 1.224E-5 8.020E-5 7.344E-5 7 32
7 module 201 Genes in module 201 MSigDb: C4 - CM: Cancer Modules 3.156E-7 1.772E-5 1.161E-4 1.240E-4 8 50
8 module 432 Genes in module 432 MSigDb: C4 - CM: Cancer Modules 1.166E-6 5.728E-5 3.753E-4 4.583E-4 5 15
9 module 33 Genes in module 33 MSigDb: C4 - CM: Cancer Modules 2.639E-6 1.152E-4 7.550E-4 1.037E-3 18 372
10 GNF2 MYL3 Neighborhood of MYL3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.159E-6 1.241E-4 8.134E-4 1.241E-3 6 31
11 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 2.098E-5 7.494E-4 4.910E-3 8.243E-3 16 351
12 module 169 Genes in module 169 MSigDb: C4 - CM: Cancer Modules 4.282E-5 1.402E-3 9.188E-3 1.683E-2 8 95
13 GNF2 AF1Q Neighborhood of AF1Q MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.343E-4 4.059E-3 2.660E-2
5.277E-2
 4 20
14 module 3 Genes in module 3 MSigDb: C4 - CM: Cancer Modules 5.641E-4 1.584E-2
1.038E-1
2.217E-1
 14 375
15 module 17 Genes in module 17 MSigDb: C4 - CM: Cancer Modules 1.013E-3 2.655E-2
1.740E-1
3.982E-1
 13 353
16 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 1.243E-3 3.053E-2
2.000E-1
4.885E-1
 13 361
17 module 60 Genes in module 60 MSigDb: C4 - CM: Cancer Modules 1.342E-3 3.103E-2
2.033E-1
5.275E-1
 14 410
18 module 486 Genes in module 486 MSigDb: C4 - CM: Cancer Modules 1.644E-3 3.589E-2
2.351E-1
6.460E-1
 6 93
Show 13 more annotations

16: MicroRNA [Display Chart] 1255 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 TCCAGAT,MIR-516-5P:MSigDB TCCAGAT,MIR-516-5P:MSigDB MSigDB 2.012E-5 2.525E-2
1.948E-1
 2.525E-2 7 103
2 hsa-miR-22:TargetScan hsa-miR-22:TargetScan TargetScan 7.819E-5 4.639E-2
3.578E-1
9.812E-2
 11 330
3 hsa-miR-24:TargetScan hsa-miR-24:TargetScan TargetScan 2.386E-4 4.639E-2
3.578E-1
2.994E-1
 12 439
4 hsa-miR-376b:PITA hsa-miR-376b:PITA TOP PITA 2.641E-4 4.639E-2
3.578E-1
3.315E-1
 8 205
5 hsa-miR-376a:PITA hsa-miR-376a:PITA TOP PITA 2.641E-4 4.639E-2
3.578E-1
3.315E-1
 8 205
6 AATGTGA,MIR-23A:MSigDB AATGTGA,MIR-23A:MSigDB MSigDB 3.795E-4 4.639E-2
3.578E-1
4.763E-1
 11 396
7 AATGTGA,MIR-23B:MSigDB AATGTGA,MIR-23B:MSigDB MSigDB 3.795E-4 4.639E-2
3.578E-1
4.763E-1
 11 396
8 hsa-miR-587:PITA hsa-miR-587:PITA TOP PITA 5.614E-4 4.639E-2
3.578E-1
7.045E-1
 11 415
9 TGCACTG,MIR-152:MSigDB TGCACTG,MIR-152:MSigDB MSigDB 5.770E-4 4.639E-2
3.578E-1
7.241E-1
 9 289
10 TGCACTG,MIR-148B:MSigDB TGCACTG,MIR-148B:MSigDB MSigDB 5.770E-4 4.639E-2
3.578E-1
7.241E-1
 9 289
11 TGCACTG,MIR-148A:MSigDB TGCACTG,MIR-148A:MSigDB MSigDB 5.770E-4 4.639E-2
3.578E-1
7.241E-1
 9 289
12 ATGTCAC,MIR-489:MSigDB ATGTCAC,MIR-489:MSigDB MSigDB 5.916E-4 4.639E-2
3.578E-1
7.425E-1
 5 84
13 hsa-miR-623:PITA hsa-miR-623:PITA TOP PITA 6.291E-4 4.639E-2
3.578E-1
7.895E-1
 6 129
14 miR-23a:PicTar miR-23a:PicTar PicTar 6.445E-4 4.639E-2
3.578E-1
8.089E-1
 11 422
15 miR-23b:PicTar miR-23b:PicTar PicTar 6.701E-4 4.639E-2
3.578E-1
8.410E-1
 11 424
16 miR-346:PicTar miR-346:PicTar PicTar 6.945E-4 4.639E-2
3.578E-1
8.717E-1
 5 87
17 CTCTAGA,MIR-526A:MSigDB CTCTAGA,MIR-526A:MSigDB MSigDB 7.024E-4 4.639E-2
3.578E-1
8.815E-1
 4 50
18 CTCTAGA,MIR-526C:MSigDB CTCTAGA,MIR-526C:MSigDB MSigDB 7.024E-4 4.639E-2
3.578E-1
8.815E-1
 4 50
19 CTCTAGA,MIR-518F:MSigDB CTCTAGA,MIR-518F:MSigDB MSigDB 7.024E-4 4.639E-2
3.578E-1
8.815E-1
 4 50
Show 14 more annotations

17: Drug [Display Chart] 20827 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 D013096 Spermine CTD 8.891E-21 1.852E-16 1.948E-15 1.852E-16 16 63
2 D010656 Phenylephrine CTD 3.635E-14 3.786E-10 3.983E-9 7.572E-10 25 500
3 CID006398969 B0683 Stitch 1.757E-13 1.220E-9 1.283E-8 3.659E-9 14 117
4 D008942 Mitoxantrone CTD 3.301E-13 1.697E-9 1.785E-8 6.874E-9 18 247
5 CID000024008 fast white Stitch 4.074E-13 1.697E-9 1.785E-8 8.484E-9 10 42
6 CID005288569 AC1NRBPQ Stitch 1.595E-12 5.537E-9 5.826E-8 3.322E-8 14 137
7 CID000024584 MgCl2 Stitch 1.339E-10 3.985E-7 4.192E-6 2.789E-6 18 354
8 CID000121994 IAANS Stitch 2.219E-10 5.135E-7 5.403E-6 4.621E-6 7 23
9 CID000130084 TMPG Stitch 2.219E-10 5.135E-7 5.403E-6 4.621E-6 7 23
10 CID000005566 trifluoperazine Stitch 2.910E-10 6.060E-7 6.376E-6 6.060E-6 17 325
11 D005228 Fatty Acids, Essential CTD 3.830E-10 7.252E-7 7.630E-6 7.977E-6 9 58
12 CID000486033 SM-2 Stitch 8.353E-10 1.450E-6 1.525E-5 1.740E-5 10 87
13 C487049 BXL628 CTD 1.638E-9 2.623E-6 2.760E-5 3.410E-5 6 17
14 C032910 triadimefon CTD 2.368E-9 3.523E-6 3.707E-5 4.932E-5 17 373
15 CID000486032 AC1LADJ6 Stitch 3.204E-9 4.336E-6 4.562E-5 6.672E-5 11 130
16 CID000060765 S-(-)-Etomoxir Stitch 3.331E-9 4.336E-6 4.562E-5 6.938E-5 10 100
17 3443 UP Monensin sodium salt [22373-78-0]; Up 200; 5.8uM; MCF7; HT HG-U133A Broad Institute CMAP 4.212E-9 5.161E-6 5.430E-5 8.773E-5 12 168
18 1651 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP 6.269E-9 7.253E-6 7.631E-5 1.306E-4 12 174
19 C016527 isoquercitrin CTD 8.550E-9 9.372E-6 9.861E-5 1.781E-4 7 37
20 6990 UP 15d-PGJ2; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.040E-8 1.032E-5 1.086E-4 2.167E-4 12 182
21 5292 UP Desipramine hydrochloride [58-28-6]; Up 200; 13.2uM; MCF7; HT HG-U133A Broad Institute CMAP 1.040E-8 1.032E-5 1.086E-4 2.167E-4 12 182
22 CID000005486 AC1L1KGC Stitch 1.218E-8 1.153E-5 1.213E-4 2.536E-4 13 225
23 C018406 1-(3-trifluoromethylphenyl)piperazine CTD 1.288E-8 1.166E-5 1.227E-4 2.682E-4 6 23
24 D002330 Carmustine CTD 1.987E-8 1.724E-5 1.814E-4 4.138E-4 18 486
25 D002110 Caffeine CTD 2.251E-8 1.810E-5 1.904E-4 4.689E-4 18 490
26 CID000000084 3-hydroxy-3-methylglutaryl-CoA Stitch 2.259E-8 1.810E-5 1.904E-4 4.706E-4 13 237
27 C519728 archazolid B CTD 2.483E-8 1.859E-5 1.956E-4 5.171E-4 8 65
28 CID006540267 2bq7 Stitch 2.499E-8 1.859E-5 1.956E-4 5.205E-4 10 123
29 C461488 N-benzylpiperazine CTD 2.808E-8 2.017E-5 2.122E-4 5.848E-4 8 66
30 CID006440832 goniodomin A Stitch 3.778E-8 2.622E-5 2.759E-4 7.867E-4 5 14
31 CID000003892 NSC339663 Stitch 4.243E-8 2.850E-5 2.999E-4 8.836E-4 13 250
32 CID006427021 Thr-Ala Stitch 5.633E-8 3.501E-5 3.683E-4 1.173E-3 5 15
33 C008493 methylselenic acid CTD 5.646E-8 3.501E-5 3.683E-4 1.176E-3 16 407
34 CID000122259 NpCaM Stitch 5.715E-8 3.501E-5 3.683E-4 1.190E-3 7 48
35 CID000247705 AC1L6KTW Stitch 7.011E-8 4.172E-5 4.390E-4 1.460E-3 8 74
36 C078092 1-piperonylpiperazine CTD 7.658E-8 4.311E-5 4.535E-4 1.595E-3 7 50
37 C003585 22-hydroxycholesterol CTD 7.658E-8 4.311E-5 4.535E-4 1.595E-3 7 50
38 D000069439 Dasatinib CTD 8.000E-8 4.385E-5 4.613E-4 1.666E-3 17 474
39 CID000001107 sterol Stitch 8.386E-8 4.478E-5 4.712E-4 1.746E-3 13 265
40 D012838 Silymarin CTD 8.969E-8 4.670E-5 4.913E-4 1.868E-3 11 179
41 CID000002783 clenbuterol Stitch 9.824E-8 4.907E-5 5.163E-4 2.046E-3 10 142
42 2785 UP Rescinnamin [24815-24-5]; Up 200; 6.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.004E-7 4.907E-5 5.163E-4 2.092E-3 11 181
43 C002994 ethylene dimethanesulfonate CTD 1.013E-7 4.907E-5 5.163E-4 2.110E-3 7 52
44 CID000004823 pimobendan Stitch 1.095E-7 5.182E-5 5.452E-4 2.280E-3 6 32
45 7198 UP Podophyllotoxin [518-28-5]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP 1.123E-7 5.198E-5 5.469E-4 2.339E-3 11 183
46 C017557 nickel subsulfide CTD 1.254E-7 5.558E-5 5.847E-4 2.612E-3 11 185
47 6082 UP Tetrandrine [518-34-3]; Up 200; 6.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.254E-7 5.558E-5 5.847E-4 2.612E-3 11 185
48 D018021 Lithium Chloride CTD 1.308E-7 5.676E-5 5.972E-4 2.724E-3 14 325
49 4386 UP Rescinnamin [24815-24-5]; Up 200; 6.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.476E-7 6.275E-5 6.602E-4 3.075E-3 11 188
50 C520284 Ly-364947 CTD 1.579E-7 6.576E-5 6.919E-4 3.288E-3 5 18
Show 45 more annotations

18: Disease [Display Chart] 1875 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0270960 Congenital myopathy (disorder) DisGeNET BeFree 7.200E-10 1.350E-6 1.095E-5 1.350E-6 8 36
2 umls:C0151786 Muscle Weakness DisGeNET Curated 3.268E-9 3.063E-6 2.486E-5 6.127E-6 14 204
3 umls:C0878544 Cardiomyopathies DisGeNET Curated 5.804E-9 3.628E-6 2.943E-5 1.088E-5 19 424
4 umls:C0026848 Myopathy DisGeNET Curated 2.184E-8 8.972E-6 7.280E-5 4.096E-5 15 277
5 umls:C0007194 Hypertrophic Cardiomyopathy DisGeNET Curated 2.393E-8 8.972E-6 7.280E-5 4.486E-5 12 165
6 umls:C0030552 Paresis DisGeNET Curated 4.079E-8 1.275E-5 1.034E-4 7.649E-5 10 109
7 umls:C2678065 Myofibrillar Myopathy DisGeNET BeFree 2.553E-7 6.839E-5 5.549E-4 4.787E-4 6 31
8 umls:C0027868 Neuromuscular Diseases DisGeNET Curated 6.036E-7 1.415E-4 1.148E-3 1.132E-3 8 82
9 umls:C0751336 Distal Muscular Dystrophies DisGeNET Curated 6.827E-7 1.422E-4 1.154E-3 1.280E-3 5 20
10 umls:C0026846 Muscular Atrophy DisGeNET Curated 1.405E-6 2.635E-4 2.138E-3 2.635E-3 10 159
11 umls:C0410180 Eichsfeld type congenital muscular dystrophy DisGeNET Curated 1.802E-6 3.072E-4 2.492E-3 3.379E-3 4 11
12 umls:C0949658 Cardiomyopathy, Hypertrophic, Familial DisGeNET Curated 4.258E-6 6.653E-4 5.398E-3 7.984E-3 6 49
13 umls:C0206157 Myopathies, Nemaline DisGeNET Curated 4.906E-6 7.076E-4 5.742E-3 9.199E-3 5 29
14 umls:C0019270 Hernia DisGeNET BeFree 8.145E-6 1.091E-3 8.851E-3 1.527E-2 5 32
15 umls:C0751657 Nemaline Myopathy, Autosomal Recessive DisGeNET BeFree 2.270E-5 2.837E-3 2.302E-2 4.256E-2 3 7
16 umls:C1960469 Left ventricular noncompaction DisGeNET Curated 3.052E-5 3.561E-3 2.889E-2
5.723E-2
 4 21
17 umls:C0745103 Hyperlipoproteinemia Type IIa DisGeNET Curated 3.602E-5 3.561E-3 2.889E-2
6.755E-2
 5 43
18 umls:C0340427 Familial dilated cardiomyopathy DisGeNET Curated 3.602E-5 3.561E-3 2.889E-2
6.755E-2
 5 43
19 umls:C1720416 Episodic ataxia type 2 (disorder) DisGeNET Curated 3.609E-5 3.561E-3 2.889E-2
6.766E-2
 3 8
20 umls:C0345050 Congenital aneurysm of ascending aorta DisGeNET Curated 7.633E-5 6.543E-3
5.309E-2
1.431E-1
 3 10
21 umls:C0035353 Congenital retrognathism DisGeNET BeFree 7.677E-5 6.543E-3
5.309E-2
1.439E-1
 2 2
22 umls:C1865596 Desmosterolosis DisGeNET Curated 7.677E-5 6.543E-3
5.309E-2
1.439E-1
 2 2
23 cv:C0007193 Primary dilated cardiomyopathy Clinical Variations 8.591E-5 7.004E-3
5.683E-2
1.611E-1
 4 27
24 umls:C3495498 Cardiomyopathy, Familial Hypertrophic, 1 (disorder) DisGeNET Curated 1.043E-4 8.147E-3
6.610E-2
1.955E-1
 3 11
25 umls:C0265213 Distal arthrogryposis syndrome DisGeNET BeFree 1.381E-4 1.036E-2
8.407E-2
2.590E-1
 3 12
26 umls:C0009081 Congenital clubfoot DisGeNET Curated 1.499E-4 1.081E-2
8.770E-2
2.810E-1
 4 31
27 umls:C0018799 Heart Diseases DisGeNET Curated 1.704E-4 1.183E-2
9.600E-2
3.195E-1
 10 277
28 umls:C0033324 Prognathism DisGeNET BeFree 2.290E-4 1.480E-2
1.201E-1
4.293E-1
 2 3
29 umls:C3494422 Retrognathia DisGeNET Curated 2.290E-4 1.480E-2
1.201E-1
4.293E-1
 2 3
30 umls:C0042373 Vascular Diseases DisGeNET Curated 2.439E-4 1.524E-2
1.237E-1
4.573E-1
 11 346
31 umls:C0007193 Cardiomyopathy, Dilated DisGeNET Curated 3.933E-4 2.247E-2
1.823E-1
7.375E-1
 11 366
32 umls:C3710589 Cap Myopathy DisGeNET BeFree 4.553E-4 2.247E-2
1.823E-1
8.537E-1
 2 4
33 umls:C2931268 Scapuloperoneal myopathy DisGeNET BeFree 4.553E-4 2.247E-2
1.823E-1
8.537E-1
 2 4
34 cv:C0398623 Thrombophilia Clinical Variations 4.553E-4 2.247E-2
1.823E-1
8.537E-1
 2 4
35 601680 ARTHROGRYPOSIS, DISTAL, TYPE 2B; DA2B OMIM 4.553E-4 2.247E-2
1.823E-1
8.537E-1
 2 4
36 umls:C1832244 CARDIOMYOPATHY, DILATED, 1C (disorder) DisGeNET Curated 4.553E-4 2.247E-2
1.823E-1
8.537E-1
 2 4
37 188050 THROMBOSIS, SUSCEPTIBILITY TO OMIM 4.553E-4 2.247E-2
1.823E-1
8.537E-1
 2 4
38 cv:C1834523 Distal arthrogryposis type 2B Clinical Variations 4.553E-4 2.247E-2
1.823E-1
8.537E-1
 2 4
39 umls:C0393578 Pallidoluysian degeneration DisGeNET BeFree 5.816E-4 2.796E-2
2.269E-1
1.000E0
 3 19
40 umls:C0234958 Muscle degeneration DisGeNET BeFree 6.452E-4 3.025E-2
2.454E-1
1.000E0
 4 45
41 umls:C0022548 Keloid DisGeNET Curated 6.646E-4 3.039E-2
2.466E-1
1.000E0
 7 166
42 umls:C0741923 cardiac event DisGeNET BeFree 7.019E-4 3.075E-2
2.495E-1
1.000E0
 4 46
43 umls:C0270970 Reducing-body myopathy DisGeNET Curated 7.545E-4 3.075E-2
2.495E-1
1.000E0
 2 5
44 607785 JUVENILE MYELOMONOCYTIC LEUKEMIA; JMML OMIM 7.545E-4 3.075E-2
2.495E-1
1.000E0
 2 5
45 umls:C0220662 ARTHROGRYPOSIS, DISTAL, TYPE 1 DisGeNET Curated 7.545E-4 3.075E-2
2.495E-1
1.000E0
 2 5
46 umls:C0410204 Myopathy, Centronuclear, Autosomal Recessive DisGeNET Curated 7.545E-4 3.075E-2
2.495E-1
1.000E0
 2 5
47 umls:C0026266 Mitral Valve Insufficiency DisGeNET Curated 7.881E-4 3.144E-2
2.551E-1
1.000E0
 3 21
48 umls:C0003855 Arteriovenous fistula DisGeNET BeFree 1.036E-3 3.981E-2
3.230E-1
1.000E0
 3 23
49 cv:C0546264 Congenital myopathy with fiber type disproportion Clinical Variations 1.125E-3 3.981E-2
3.230E-1
1.000E0
 2 6
50 umls:C1834523 ARTHROGRYPOSIS, DISTAL, TYPE 2B DisGeNET Curated 1.125E-3 3.981E-2
3.230E-1
1.000E0
 2 6
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