Toppgene analysis for aggregated_1964_log, IC16, negative side

Go To Start Page
Input Parameters [Show Detail]
Training Results [Expand All] [Download All] [Sparse Matrix]
Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 352 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005518 collagen binding 7.102E-6 2.073E-3 1.335E-2 2.500E-3 5 72
2 GO:0043548 phosphatidylinositol 3-kinase binding 1.178E-5 2.073E-3 1.335E-2 4.145E-3 4 38
3 GO:0005158 insulin receptor binding 2.715E-4 3.186E-2
2.052E-1
9.557E-2
 3 34

2: GO: Biological Process [Display Chart] 2245 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0071294 cellular response to zinc ion 8.671E-7 1.726E-3 1.431E-2 1.947E-3 4 20
2 GO:0042326 negative regulation of phosphorylation 1.538E-6 1.726E-3 1.431E-2 3.452E-3 11 474
3 GO:0010634 positive regulation of epithelial cell migration 3.694E-6 1.993E-3 1.653E-2 8.293E-3 6 110
4 GO:0010632 regulation of epithelial cell migration 4.348E-6 1.993E-3 1.653E-2 9.760E-3 7 175
5 GO:0001933 negative regulation of protein phosphorylation 4.439E-6 1.993E-3 1.653E-2 9.966E-3 10 427
6 GO:0090287 regulation of cellular response to growth factor stimulus 5.407E-6 2.023E-3 1.678E-2 1.214E-2 8 256
7 GO:0030198 extracellular matrix organization 7.209E-6 2.069E-3 1.716E-2 1.618E-2 9 354
8 GO:0043062 extracellular structure organization 7.374E-6 2.069E-3 1.716E-2 1.655E-2 9 355
9 GO:0032885 regulation of polysaccharide biosynthetic process 1.255E-5 3.130E-3 2.596E-2 2.817E-2 4 38
10 GO:0002537 nitric oxide production involved in inflammatory response 1.409E-5 3.162E-3 2.623E-2 3.162E-2 2 2
11 GO:0032881 regulation of polysaccharide metabolic process 2.483E-5 4.753E-3 3.942E-2
5.574E-2
 4 45
12 GO:0061053 somite development 2.827E-5 4.753E-3 3.942E-2
6.346E-2
 5 94
13 GO:0010631 epithelial cell migration 2.953E-5 4.753E-3 3.942E-2
6.630E-2
 7 235
14 GO:0031589 cell-substrate adhesion 2.973E-5 4.753E-3 3.942E-2
6.674E-2
 8 324
15 GO:0090132 epithelium migration 3.202E-5 4.753E-3 3.942E-2
7.189E-2
 7 238
16 GO:0042693 muscle cell fate commitment 3.387E-5 4.753E-3 3.942E-2
7.604E-2
 3 17
17 GO:0090130 tissue migration 3.753E-5 4.956E-3 4.110E-2
8.425E-2
 7 244
18 GO:1901492 positive regulation of lymphangiogenesis 4.215E-5 5.257E-3 4.360E-2
9.463E-2
 2 3
19 GO:0030335 positive regulation of cell migration 4.472E-5 5.284E-3 4.382E-2
1.004E-1
 9 446
20 GO:0002532 production of molecular mediator involved in inflammatory response 5.137E-5 5.766E-3 4.782E-2
1.153E-1
 4 54
21 GO:2000147 positive regulation of cell motility 5.583E-5 5.969E-3 4.950E-2
1.253E-1
 9 459
22 GO:0051272 positive regulation of cellular component movement 6.808E-5 6.555E-3
5.437E-2
1.528E-1
 9 471
23 GO:0045926 negative regulation of growth 7.281E-5 6.555E-3
5.437E-2
1.635E-1
 7 271
24 GO:0010043 response to zinc ion 7.288E-5 6.555E-3
5.437E-2
1.636E-1
 4 59
25 GO:0010810 regulation of cell-substrate adhesion 7.299E-5 6.555E-3
5.437E-2
1.639E-1
 6 186
26 GO:0040017 positive regulation of locomotion 7.622E-5 6.581E-3
5.458E-2
1.711E-1
 9 478
27 GO:0018209 peptidyl-serine modification 8.541E-5 7.010E-3
5.814E-2
1.917E-1
 7 278
28 GO:0010594 regulation of endothelial cell migration 8.743E-5 7.010E-3
5.814E-2
1.963E-1
 5 119
29 GO:0045667 regulation of osteoblast differentiation 1.022E-4 7.915E-3
6.564E-2
2.295E-1
 5 123
30 GO:0033135 regulation of peptidyl-serine phosphorylation 1.189E-4 8.898E-3
7.380E-2
2.669E-1
 5 127
31 GO:0038084 vascular endothelial growth factor signaling pathway 1.264E-4 8.968E-3
7.438E-2
2.837E-1
 3 26
32 GO:0030278 regulation of ossification 1.314E-4 8.968E-3
7.438E-2
2.950E-1
 6 207
33 GO:0033692 cellular polysaccharide biosynthetic process 1.346E-4 8.968E-3
7.438E-2
3.021E-1
 4 69
34 GO:0036017 response to erythropoietin 1.398E-4 8.968E-3
7.438E-2
3.139E-1
 2 5
35 GO:0036018 cellular response to erythropoietin 1.398E-4 8.968E-3
7.438E-2
3.139E-1
 2 5
36 GO:0001503 ossification 1.439E-4 8.975E-3
7.444E-2
3.231E-1
 8 406
37 GO:0010595 positive regulation of endothelial cell migration 1.504E-4 9.093E-3
7.542E-2
3.376E-1
 4 71
38 GO:0007517 muscle organ development 1.539E-4 9.093E-3
7.542E-2
3.455E-1
 8 410
39 GO:0005979 regulation of glycogen biosynthetic process 1.952E-4 1.072E-2
8.890E-2
4.383E-1
 3 30
40 GO:0010962 regulation of glucan biosynthetic process 1.952E-4 1.072E-2
8.890E-2
4.383E-1
 3 30
41 GO:0001756 somitogenesis 1.958E-4 1.072E-2
8.890E-2
4.395E-1
 4 76
42 GO:0001649 osteoblast differentiation 2.018E-4 1.079E-2
8.946E-2
4.530E-1
 6 224
43 GO:1901490 regulation of lymphangiogenesis 2.092E-4 1.092E-2
9.059E-2
4.697E-1
 2 6
44 GO:0000271 polysaccharide biosynthetic process 2.273E-4 1.160E-2
9.619E-2
5.103E-1
 4 79
45 GO:0034637 cellular carbohydrate biosynthetic process 2.503E-4 1.249E-2
1.036E-1
5.618E-1
 4 81
46 GO:1900006 positive regulation of dendrite development 2.878E-4 1.396E-2
1.158E-1
6.461E-1
 4 84
47 GO:0048743 positive regulation of skeletal muscle fiber development 2.922E-4 1.396E-2
1.158E-1
6.560E-1
 2 7
48 GO:0032496 response to lipopolysaccharide 3.053E-4 1.428E-2
1.184E-1
6.854E-1
 7 342
49 GO:0001667 ameboidal-type cell migration 3.333E-4 1.527E-2
1.266E-1
7.481E-1
 7 347
50 GO:0031331 positive regulation of cellular catabolic process 3.632E-4 1.565E-2
1.298E-1
8.154E-1
 7 352
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 152 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005589 collagen type VI trimer 4.047E-5 3.076E-3 1.724E-2 6.151E-3 2 3
2 GO:0098647 collagen beaded filament 4.047E-5 3.076E-3 1.724E-2 6.151E-3 2 3
3 GO:0005581 collagen trimer 3.185E-4 1.614E-2
9.043E-2
 4.841E-2 4 88
4 GO:0031012 extracellular matrix 1.264E-3 4.805E-2
2.693E-1
1.922E-1
 7 444

4: Human Phenotype [Display Chart] 376 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000855 Insulin resistance 3.435E-5 7.724E-3
5.027E-2
 1.291E-2 4 41
2 HP:0003584 Late onset 4.160E-5 7.724E-3
5.027E-2
 1.564E-2 4 43
3 HP:0006385 Short lower limbs {has synonym type="layperson"} 6.462E-5 7.724E-3
5.027E-2
 2.430E-2 2 3
4 HP:0005978 Type II diabetes mellitus 8.217E-5 7.724E-3
5.027E-2
 3.089E-2 4 51
5 HP:0010047 Short 5th metacarpal 3.203E-4 2.409E-2
1.568E-1
1.204E-1
 2 6
6 HP:0007502 Follicular hyperkeratosis 1.158E-3 4.839E-2
3.149E-1
4.353E-1
 2 11
7 HP:0002515 Waddling gait 1.580E-3 4.839E-2
3.149E-1
5.941E-1
 3 50
8 HP:0000491 Keratitis 2.185E-3 4.839E-2
3.149E-1
8.215E-1
 2 15
9 HP:0011001 Increased bone mineral density {has synonym type="layperson"} 2.814E-3 4.839E-2
3.149E-1
1.000E0
 2 17
10 HP:0006480 Premature loss of teeth 3.518E-3 4.839E-2
3.149E-1
1.000E0
 2 19
11 HP:0000656 Ectropion 4.711E-3 4.839E-2
3.149E-1
1.000E0
 2 22
12 HP:0010554 Cutaneous finger syndactyly 4.711E-3 4.839E-2
3.149E-1
1.000E0
 2 22
13 HP:0002659 Increased susceptibility to fractures {has synonym type="layperson"} 4.711E-3 4.839E-2
3.149E-1
1.000E0
 2 22
14 HP:0002689 Absent paranasal sinuses 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
15 HP:0008607 Progressive conductive hearing impairment 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
16 HP:0006531 Pleural lymphangiectasia 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
17 HP:0006040 Long second metacarpal 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
18 HP:0004940 Generalized arterial calcification 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
19 HP:0011864 Elevated plasma pyrophosphate 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
20 HP:0006224 Tapering pointed ends of distal finger phalanges 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
21 HP:0000166 Severe periodontitis 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
22 HP:0005625 Osteoporosis of vertebrae 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
23 HP:0005877 Multiple small vertebral fractures 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
24 HP:0003491 Elevated urine pyrophosphate 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
25 HP:0006187 Fusion of midphalangeal joints 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
26 HP:0003239 Phosphoethanolaminuria 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
27 HP:0100305 Ring fibers 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
28 HP:0007545 Congenital palmoplantar keratosis 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
29 HP:0009577 Short middle phalanx of the 2nd finger 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
30 HP:0008460 Hypoplastic spinal processes 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
31 HP:0001024 Skin dimple over apex of long bone angulation 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
32 HP:0005259 Abnormal facility in opposing the shoulders 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
33 HP:0010185 Aplasia/Hypoplasia of the distal phalanges of the toes 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
34 HP:0006308 Atrophy of alveolar ridges 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
35 HP:0007943 Congenital stapes ankylosis 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
36 HP:0008229 Thyroid lymphangiectasia 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
37 HP:0006147 Progressive fusion 2nd-5th pip joints 4.762E-3 4.839E-2
3.149E-1
1.000E0
 1 1
Show 32 more annotations

5: Mouse Phenotype [Display Chart] 1914 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004846 absent skeletal muscle 8.777E-6 1.680E-2
1.366E-1
 1.680E-2 3 7

6: Domain [Display Chart] 598 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS00203 METALLOTHIONEIN VRT PROSITE 9.146E-10 2.121E-7 1.478E-6 5.469E-7 5 13
2 IPR003019 Metalthion InterPro 1.418E-9 2.121E-7 1.478E-6 8.482E-7 5 14
3 IPR000006 Metalthion vert InterPro 1.418E-9 2.121E-7 1.478E-6 8.482E-7 5 14
4 PF00131 Metallothio Pfam 1.418E-9 2.121E-7 1.478E-6 8.482E-7 5 14
5 IPR018064 Metalthion vert metal BS InterPro 4.137E-8 4.948E-6 3.450E-5 2.474E-5 4 10
6 4.10.10.10 - Gene3D 9.695E-8 7.247E-6 5.053E-5 5.798E-5 4 12
7 IPR017854 Metalthion dom InterPro 9.695E-8 7.247E-6 5.053E-5 5.798E-5 4 12
8 IPR023587 Metalthion dom vert InterPro 9.695E-8 7.247E-6 5.053E-5 5.798E-5 4 12
9 PF01586 Basic Pfam 8.695E-5 4.727E-3 3.296E-2
5.200E-2
 2 4
10 SM00520 BASIC SMART 8.695E-5 4.727E-3 3.296E-2
5.200E-2
 2 4
11 IPR002546 Basic InterPro 8.695E-5 4.727E-3 3.296E-2
5.200E-2
 2 4
12 SM00310 PTBI SMART 7.833E-4 3.903E-2
2.721E-1
4.684E-1
 2 11
13 PS51064 IRS PTB PROSITE 9.376E-4 4.239E-2
2.955E-1
5.607E-1
 2 12
14 IPR002404 IRS PTB InterPro 1.286E-3 4.239E-2
2.955E-1
7.693E-1
 2 14
15 PF02174 IRS Pfam 1.286E-3 4.239E-2
2.955E-1
7.693E-1
 2 14
16 PF00092 VWA Pfam 1.304E-3 4.239E-2
2.955E-1
7.796E-1
 3 56
17 IPR004583 DNA repair Rad4 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
18 PF12064 DUF3544 Pfam 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
19 IPR018328 Rad4 beta-hairpin dom3 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
20 IPR018326 Rad4 beta-hairpin dom1 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
21 IPR027168 TLR4 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
22 IPR031179 ELL2 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
23 IPR029890 ENPP1 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
24 IPR033100 Rrp45 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
25 PF10404 BHD 2 Pfam 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
26 IPR012266 Ptpn 12 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
27 IPR001923 Prostglndn EP2 rcpt InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
28 IPR018325 Rad4/PNGase transGLS-fold InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
29 IPR029575 CLAC-P InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
30 PF10405 BHD 3 Pfam 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
31 SM01030 BHD 1 SMART 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
32 IPR029727 MME/CD10/NEP InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
33 PF10403 BHD 1 Pfam 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
34 2.40.128.80 - Gene3D 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
35 IPR031075 HMGB2 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
36 IPR018026 DNA repair Rad4 subgr InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
37 IPR028371 HAS2 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
38 IPR021931 DUF3544 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
39 IPR028549 Decorin InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
40 IPR031286 AMIGO2 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
41 IPR014882 CathepsinC exc InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
42 IPR028743 IGF2BP2 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
43 IPR033161 DPP I InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
44 SM01032 BHD 3 SMART 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
45 IPR028849 BCAR3 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
46 PF03835 Rad4 Pfam 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
47 IPR031230 OLFML3 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
48 IPR032957 SAT1 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
49 PF08773 CathepsinC exc Pfam 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
50 IPR031210 FKBP5 InterPro 3.843E-3 4.239E-2
2.955E-1
1.000E0
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 483 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 212237 Mineral absorption BioSystems: KEGG 6.348E-6 3.066E-3 2.072E-2 3.066E-3 5 51
2 198871 Id Signaling Pathway BioSystems: WikiPathways 1.501E-4 3.245E-2
2.193E-1
7.249E-2
 4 52
3 PW:0000143 insulin signaling Pathway Ontology 3.612E-4 3.245E-2
2.193E-1
1.745E-1
 3 27
4 106425 IRS activation BioSystems: REACTOME 3.965E-4 3.245E-2
2.193E-1
1.915E-1
 2 6
5 692234 PI3K-Akt signaling pathway BioSystems: KEGG 3.999E-4 3.245E-2
2.193E-1
1.931E-1
 8 346
6 137992 IGF1 pathway BioSystems: Pathway Interaction Database 4.031E-4 3.245E-2
2.193E-1
1.947E-1
 3 28
Show 1 more annotation

8: Pubmed [Display Chart] 17887 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20628624 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". Pubmed 1.243E-10 6.863E-7 7.116E-6 2.223E-6 8 172
2 20628624:gr Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". GeneRIF 1.243E-10 6.863E-7 7.116E-6 2.223E-6 8 172
3 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 1.535E-10 6.863E-7 7.116E-6 2.745E-6 10 383
4 19453261:gr High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. GeneRIF 1.535E-10 6.863E-7 7.116E-6 2.745E-6 10 383
5 2286373 Human metallothionein genes: structure of the functional locus at 16q13. Pubmed 1.677E-9 5.998E-6 6.220E-5 2.999E-5 4 12
6 12539042 HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. Pubmed 4.665E-9 1.391E-5 1.442E-4 8.344E-5 5 44
7 8049263 Characterisation of six additional human metallothionein genes. Pubmed 5.118E-8 1.144E-4 1.187E-3 9.155E-4 3 6
8 10774930 Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes. Pubmed 5.118E-8 1.144E-4 1.187E-3 9.155E-4 3 6
9 19692168 Genetic susceptibility to distinct bladder cancer subphenotypes. Pubmed 1.368E-7 2.326E-4 2.412E-3 2.447E-3 8 422
10 19692168:gr Genetic susceptibility to distinct bladder cancer subphenotypes. GeneRIF 1.368E-7 2.326E-4 2.412E-3 2.447E-3 8 422
11 11168427 Metallothionein isogene transcription in red blood cell precursors from human cord blood. Pubmed 1.430E-7 2.326E-4 2.412E-3 2.558E-3 3 8
12 17244347 Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis. Pubmed 3.059E-7 3.909E-4 4.053E-3 5.471E-3 3 10
13 9242638 Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. Pubmed 4.202E-7 3.909E-4 4.053E-3 7.515E-3 3 11
14 15747776:gr Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line. GeneRIF 9.241E-7 3.909E-4 4.053E-3 1.653E-2 3 14
15 15747776 Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line. Pubmed 9.241E-7 3.909E-4 4.053E-3 1.653E-2 3 14
16 25504209 Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis. Pubmed 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
17 12213887 Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome. Pubmed 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
18 15711641:gr Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
19 12746333:gr Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
20 10575295 Metallothioneins in human kidneys and associated tumors. Pubmed 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
21 25310961 Association of Gly972Arg variant of insulin receptor subtrate-1 and Gly1057Asp variant of insulin receptor subtrate-2 with polycystic ovary syndrome in the Chinese population. Pubmed 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
22 17222321:gr Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
23 9074634 Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein. Pubmed 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
24 17222824:gr Insulin receptor substrates 1 and 2 but not Shc can activate the insulin receptor independent of insulin and induce proliferation in CHO-IR cells. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
25 22205343 Prevalence of the insulin receptor substrate-1(IRS-1) Gly972Arg and the insulin receptor substrate-2(IRS-2) Gly1057Asp polymorphisms in PCOS patients and non-diabetic healthy women. Pubmed 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
26 2311584 Myf-6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12. Pubmed 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
27 20210696:gr Study of association of IRS-1 and IRS-2 genes polymorphisms with clinical and metabolic features in women with polycystic ovary syndrome. Is there an impact? GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
28 12204280:gr Expression of the myogenic regulatory factor Mrf4 precedes or is contemporaneous with that of Myf5 in the somitic bud. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
29 8978788 Assignment of the human myogenic factors 5 and 6 (MYF5, MYF6) gene cluster to 12q21 by in situ hybridization and physical mapping of the locus between D12S350 and D12S106. Pubmed 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
30 18590687:gr The double life of Irs. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
31 16374520:gr Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
32 15581362:gr Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
33 21325637 PDGF-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates. Pubmed 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
34 15069074:gr Caspase-mediated Cleavage of Insulin Receptor Substrate. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
35 8766831 Cloning and sequencing a novel metallothionein I isoform expressed in human reticulocytes. Pubmed 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
36 22023263:gr CYR61 modulates the vascular endothelial growth factor C expression of decidual NK cells via PI3K/AKT pathway. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
37 11522686:gr Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
38 12475767:gr Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
39 21751142:gr Up-regulated expression of Ezrin and c-Met proteins are related to the metastasis and prognosis of gastric carcinomas. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
40 11522686 Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome. Pubmed 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
41 17719609:gr Polycystic ovary syndrome is associated with genetic polymorphism in the insulin signaling gene IRS-1 but not ENPP1 in a Japanese population. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
42 17030631 Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2. Pubmed 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
43 20176643:gr Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
44 18590692:gr Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
45 19931660:gr Association of ALPL and ENPP1 gene polymorphisms with bone strength related skeletal traits in a Chuvashian population. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
46 22205343:gr Prevalence of the insulin receptor substrate-1(IRS-1) Gly972Arg and the insulin receptor substrate-2(IRS-2) Gly1057Asp polymorphisms in PCOS patients and non-diabetic healthy women. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
47 22994406:gr The study on the relationship between IRS-1 Gly972Arg and IRS-2 Gly1057Asp polymorphisms and type 2 diabetes in the Kurdish ethnic group in West Iran. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
48 24703981 Systematic modeling for the insulin signaling network mediated by IRS(1) and IRS(2). Pubmed 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
49 17374994 Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2. Pubmed 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
50 17374994:gr Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2. GeneRIF 1.901E-6 3.909E-4 4.053E-3 3.401E-2 2 2
Show 45 more annotations

9: Interaction [Display Chart] 1569 annotations before applied cutoff / 16534 genes in category

No results to display

10: Cytoband [Display Chart] 64 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16q13 16q13 1.434E-10 9.180E-9 4.355E-8 9.180E-9 6 37
2 12q21 12q21 3.810E-4 8.128E-3 3.856E-2 2.439E-2 2 14
3 3q25.2 3q25.2 3.810E-4 8.128E-3 3.856E-2 2.439E-2 2 14
4 1p36.13-p36.12 1p36.13-p36.12 2.077E-3 3.324E-2
1.577E-1
1.329E-1
 1 1
5 2p22.3-p21 2p22.3-p21 4.150E-3 4.427E-2
2.100E-1
2.656E-1
 1 2
6 3p23-p21 3p23-p21 4.150E-3 4.427E-2
2.100E-1
2.656E-1
 1 2
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 354 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 52 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 638 Metallothioneins genenames.org 2.359E-9 1.227E-7 5.567E-7 1.227E-7 5 19

13: Coexpression [Display Chart] 4811 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13867 Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.039E-13 5.000E-10 4.528E-9 5.000E-10 14 256
2 M13630 Selected genes down-regulated in WS1 (fibroblast) in response to irradiation with high dose UV-C. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.123E-10 9.918E-7 8.982E-6 1.984E-6 12 312
3 M12300 Up-regulated genesin the left ventricle myocardium of patients with heart failure following implantation of LVAD (left ventricular assist device). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.716E-9 2.751E-6 2.491E-5 8.254E-6 8 103
4 M2256 Genes commonly down-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313 ,2078]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.643E-9 4.321E-6 3.913E-5 1.752E-5 10 227
5 M13273 Genes down-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.491E-9 4.321E-6 3.913E-5 2.160E-5 10 232
6 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.333E-8 1.069E-5 9.682E-5 6.415E-5 10 260
7 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v5.1) 1.936E-8 1.330E-5 1.205E-4 9.312E-5 9 200
8 M5942 Genes down-regulated in response to ultraviolet (UV) radiation. MSigDB H: Hallmark Gene Sets (v5.1) 2.439E-8 1.467E-5 1.328E-4 1.174E-4 8 144
9 M14507 Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.763E-8 1.477E-5 1.338E-4 1.329E-4 12 454
10 M2024 Genes up-regulated in mesenchymal stem cells during early phase of adipogenesis, defined as days 1 to 5 of culturing with adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.300E-8 3.193E-5 2.891E-4 3.512E-4 6 65
11 M15821 Genes whose expression peaked at 120 min after stimulation of MCF10A cells with serum. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.300E-8 3.193E-5 2.891E-4 3.512E-4 6 65
12 M4680 Genes up-regulated in RD cells (embryonal rhabdomyosarcoma, ERMS) by expression of PAX3- or PAX7-FOXO1 [GeneID=5077;5081;2308] fusions off retroviral vectors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.554E-7 6.231E-5 5.643E-4 7.477E-4 9 255
13 M1711 Genes down-regulated in hypertrophic scar fibroblasts in response to IL6 [GeneID=3569]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.908E-7 7.061E-5 6.395E-4 9.180E-4 4 16
14 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.017E-7 1.024E-4 9.272E-4 1.452E-3 11 460
15 M1589 Up-regulated in HEK293 cells (kidney epithelium) by treatment with sodium arsenite [PubChem=26435]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.192E-7 1.024E-4 9.272E-4 1.536E-3 4 18
16 M8455 Genes up-regulated in PC-3 cells (prostate cancer) stably expressing ST7 [GeneID=7982] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.675E-7 1.986E-4 1.798E-3 3.211E-3 6 94
17 M950 Genes up-regulated in A549 cells (lung carcinoma) upon infection with RSV (respiratory syncytial virus) and down-regulated by further treatment with ribavirin [PubChem=5064]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.017E-7 1.986E-4 1.798E-3 3.376E-3 5 51
18 M2502 Genes whose expression changes in Calu-6 cells (lung cancer) by TNF [GeneID=7124] were blocked partially by p38 inhibitor LY479754. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.730E-7 2.601E-4 2.355E-3 4.681E-3 7 160
19 M8729 Genes whose expression peaked at 480 min after stimulation of HeLa cells with EGF [GeneID=1950]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.148E-6 2.908E-4 2.633E-3 5.525E-3 7 164
20 M14072 Genes regulated by hypoxia, based on literature searches. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.303E-6 3.135E-4 2.839E-3 6.270E-3 8 242
21 M15908 Genes up-regulated in D-341 MED (OBR) cells (medulloblastoma) resistant to both carmustine and O6-BG [PubChem=2578;4578]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.529E-6 3.454E-4 3.128E-3 7.355E-3 4 26
22 M2660 Genes up-regulated in late serum response of CRL 2091 cells (foreskin fibroblasts). MSigDB C6: Oncogenic Signatures (v5.1) 1.579E-6 3.454E-4 3.128E-3 7.598E-3 7 172
23 M2001 Genes associated with migration rate of 40 human bladder cancer cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.474E-6 5.176E-4 4.687E-3 1.190E-2 7 184
24 M14127 Genes up-regulated in multiple myeloma (MM) cell lines treated with both decitabine [PubChem=451668] TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.623E-6 5.258E-4 4.761E-3 1.262E-2 10 461
25 M2863 Genes up-regulated in epithelial lung cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v5.1) 3.280E-6 5.584E-4 5.057E-3 1.578E-2 7 192
26 M2634 Genes up-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] and engineered to express ligand-activatable EGFR [Gene ID=1956]. MSigDB C6: Oncogenic Signatures (v5.1) 3.395E-6 5.584E-4 5.057E-3 1.633E-2 7 193
27 M2675 Genes down-regulated in HUVEC cells (endothelium) by treatment with VEGFA [Gene ID=7422]. MSigDB C6: Oncogenic Signatures (v5.1) 3.395E-6 5.584E-4 5.057E-3 1.633E-2 7 193
28 M308 Genes up-regulated in response to both single dose and fractionated radiation that were common to all three cell lines studied. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.623E-6 5.584E-4 5.057E-3 1.743E-2 4 32
29 M13522 Common down-regulated transcripts in fibroblasts expressing either XP/CS or TDD mutant forms of ERCC3 [GeneID=2071], after UVC irradiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.966E-6 5.584E-4 5.057E-3 1.908E-2 10 483
30 M1612 Strongly up-regulated at 2 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.112E-6 5.584E-4 5.057E-3 1.978E-2 4 33
31 M5865 Genes down-regulated in comparison of monocytes treated with 1 ng/ml LPS (TLR4 agonist) versus monocytes treated with anti-TREM1 [GeneID=54210] and 5000 ng/ml LPS (TLR4 agonist). MSigDB C7: Immunologic Signatures (v5.1) 4.155E-6 5.584E-4 5.057E-3 1.999E-2 7 199
32 M1350 Genes up-regulated in the urogenital sinus (UGS) of day E16 females exposed to the androgen dihydrotestosterone [PubChem=10635] for 48 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.265E-6 5.584E-4 5.057E-3 2.052E-2 10 487
33 M6485 Genes down-regulated in monocyte-derived dendritic cells: untreated versus LPS and LPS like antigen from O. planktothrix (3h). MSigDB C7: Immunologic Signatures (v5.1) 4.295E-6 5.584E-4 5.057E-3 2.066E-2 7 200
34 GSE22443 NAIVE VS ACT AND IL2 TREATED CD8 TCELL DN Genes down-regulated in Pmel-1 CD8 T cells: naïve versus primed with cognate antigen (gp100) and IL2 [GeneID=3558]. MSigDB C7: Immunologic Signatures (v5.1) 4.295E-6 5.584E-4 5.057E-3 2.066E-2 7 200
35 M5891 Genes up-regulated in response to low oxygen levels (hypoxia). MSigDB H: Hallmark Gene Sets (v5.1) 4.295E-6 5.584E-4 5.057E-3 2.066E-2 7 200
36 M4367 Genes down-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from wild type mice subjected to ozone for 24 h. MSigDB C7: Immunologic Signatures (v5.1) 4.295E-6 5.584E-4 5.057E-3 2.066E-2 7 200
37 GSE19198 CTRL VS IL21 TREATED TCELL 24H UP Genes up-regulated in T cells: control (0h) versus IL21 [GeneID=59067] for 24h. MSigDB C7: Immunologic Signatures (v5.1) 4.295E-6 5.584E-4 5.057E-3 2.066E-2 7 200
38 M4995 Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.259E-6 6.658E-4 6.030E-3 2.530E-2 9 390
39 M17374 Genes up-regulated in DLD1 cells (colon cancer) by p73 beta [GeneID=7161] or by and p63 gamma [GeneID=8626] but not by p53 [GeneID=7157]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.542E-6 6.836E-4 6.191E-3 2.666E-2 3 11
40 M13251 Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 14 h time point that were not down-regulated at the previous time point, 12 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.938E-6 7.142E-4 6.468E-3 2.857E-2 8 297
41 M18536 Genes that distinguish normal from cancer (lung adenocarcinoma) samples and smokers from non-smoking subjects. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.669E-6 7.825E-4 7.087E-3 3.208E-2 5 80
42 M1879 Genes up-regulated during later stages of renal maturation (days P14-P16) in kidney specific knockout of PKD1 [GeneID=5310]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.327E-6 8.392E-4 7.600E-3 3.525E-2 4 38
43 M15590 Genes down-regulated in HeLa cells (cervical carcinoma) 32 h after infection with adenovirus Ad12. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.144E-6 9.111E-4 8.251E-3 3.918E-2 4 39
44 M7375 Genes down-regulated in HeLa cells (cervical carcinoma) 48 h after infection with adenovirus Ad12. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.026E-6 9.869E-4 8.937E-3 4.342E-2 4 40
45 M9869 Genes up-regulated in primary granulosa cells in response to forskolin [PubChem=47936]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.188E-5 1.265E-3 1.146E-2
5.718E-2
 5 90
46 M8825 Genes down-regulated in HeLa cells (cervical carcinoma) 24 h after infection with adenovirus Ad12. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.210E-5 1.265E-3 1.146E-2
5.820E-2
 4 43
47 M2128 Genes up-regulated in growing IMR90 cells (fibroblast) after knockdown of RB1 [GeneID=5925] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.530E-5 1.566E-3 1.418E-2
7.359E-2
 7 243
48 M1459 Genes up-regulated in BEC (blood endothelial cells) compared to LEC (lymphatic endothelial cells). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.572E-5 1.576E-3 1.427E-2
7.563E-2
 6 162
49 M2352 Transcripts (mRNA molecules) rapidly degraded upon interaction with KHSRP [GeneID=8570]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.985E-5 1.949E-3 1.765E-2
9.548E-2
 5 100
50 M16033 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 8. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.046E-5 1.965E-3 1.779E-2
9.845E-2
 4 49
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2326 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.048E-9 2.438E-6 2.031E-5 2.438E-6 13 410
2 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 2.818E-9 2.853E-6 2.376E-5 6.554E-6 13 445
3 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 3.679E-9 2.853E-6 2.376E-5 8.558E-6 13 455
4 gudmap kidney adult RenalCapsule k1 500 kidney adult RenalCapsule k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 8.656E-9 5.033E-6 4.193E-5 2.013E-5 10 242
5 gudmap dev gonad e11.5 M GonadVasMes Flk 500 dev gonad e11.5 M GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.526E-8 7.099E-6 5.913E-5 3.550E-5 12 419
6 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 2.489E-8 9.648E-6 8.036E-5 5.789E-5 12 438
7 gudmap kidney adult RenalCapsule k2 1000 kidney adult RenalCapsule k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.534E-8 1.299E-5 1.082E-4 1.055E-4 11 371
8 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma 500 dev gonad e13.5 F VascAssocMesenchStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.789E-8 1.299E-5 1.082E-4 1.114E-4 11 373
9 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 5.024E-8 1.299E-5 1.082E-4 1.169E-4 12 467
10 PCBC ctl BronchSmoothMuscl 500 Progenitor-Cell-Biology-Consortium reference BronchSmoothMuscl top-relative-expression-ranked 500 PCBC 9.258E-8 2.045E-5 1.703E-4 2.153E-4 12 494
11 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 9.672E-8 2.045E-5 1.703E-4 2.250E-4 12 496
12 gudmap dev gonad e13.5 M InterstitFLeydig MafB k4 500 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.839E-7 3.565E-5 2.969E-4 4.278E-4 8 182
13 gudmap dev gonad e11.5 F GonMes Sma 500 dev gonad e11.5 F GonMes Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.358E-7 4.219E-5 3.515E-4 5.485E-4 11 437
14 PCBC ratio ESC vs iPSC method-OS-NL cfr-2X-p05 Pluripotent Stem Cells-reprogram NA vs Pluripotent Stem Cells-reprogram OS-NL-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 2.571E-7 4.271E-5 3.558E-4 5.980E-4 6 78
15 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB k2 1000 dev gonad e13.5 F VascAssocMesenchStromOvary MafB k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.780E-7 4.311E-5 3.591E-4 6.467E-4 9 266
16 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB 500 dev gonad e13.5 F VascAssocMesenchStromOvary MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.393E-7 4.932E-5 4.108E-4 7.891E-4 10 358
17 gudmap dev gonad e12.5 F VasAssocMesStromOvary Sma 500 dev gonad e12.5 F VasAssocMesStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.748E-7 9.233E-5 7.690E-4 1.570E-3 10 386
18 facebase RNAseq e14.5 palate poster nasal Tgfbr2 WT 2500 K4 facebase RNAseq e14.5 palate poster nasal Tgfbr2 WT 2500 K4 Gudmap RNAseq 8.315E-7 1.074E-4 8.950E-4 1.934E-3 6 95
19 GSM777043 100 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 9.404E-7 1.151E-4 9.589E-4 2.187E-3 6 97
20 Lungmap Mouse e16.5 Matrix fibroblast Top 500 All Mouse Lung E16.5 Matrix Fibroblast top 500 Lungmap Mouse Single Cell (Lungmap.net) 1.447E-6 1.683E-4 1.402E-3 3.366E-3 10 420
21 gudmap dev gonad e11.5 F GonadVasMes Flk 500 dev gonad e11.5 F GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.576E-6 1.745E-4 1.454E-3 3.665E-3 10 424
22 ratio EB vs SC 1000 K1 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 1.942E-6 1.964E-4 1.636E-3 4.518E-3 9 336
23 gudmap dev gonad e13.5 M InterstitFLeydig MafB k3 1000 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.942E-6 1.964E-4 1.636E-3 4.518E-3 9 336
24 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 2.846E-6 2.758E-4 2.297E-3 6.619E-3 10 453
25 gudmap dev gonad e13.5 M InterstitFLeydig MafB 500 dev gonad e13.5 M InterstitFLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.117E-6 2.900E-4 2.416E-3 7.250E-3 9 356
26 gudmap dev gonad e13.5 M InterstitTestis Sma 500 dev gonad e13.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.571E-6 3.135E-4 2.611E-3 8.307E-3 9 362
27 gudmap dev gonad e12.5 M InterstitLeydig MafB 500 dev gonad e12.5 M InterstitLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.735E-6 3.135E-4 2.611E-3 8.687E-3 9 364
28 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB k3 500 dev gonad e13.5 F VascAssocMesenchStromOvary MafB k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.774E-6 3.135E-4 2.611E-3 8.778E-3 6 123
29 gudmap dev gonad e12.5 M InterstitTestis Sma 500 dev gonad e12.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.653E-6 3.732E-4 3.109E-3 1.082E-2 9 374
30 Facebase RNAseq e9.5 Facial Mesenchyne 500 FacebaseRNAseq e9.5 Facial Mesenchyne top-relative-expression-ranked 500 FaceBase_RNAseq 5.300E-6 4.109E-4 3.423E-3 1.233E-2 10 486
31 microglia Top 500 All microglia Top 500 All Brain Map - Barres 5.798E-6 4.248E-4 3.538E-3 1.349E-2 10 491
32 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 6.009E-6 4.248E-4 3.538E-3 1.398E-2 10 493
33 PCBC ctl CardiacMyocyte 500 Progenitor-Cell-Biology-Consortium reference CardiacMyocyte top-relative-expression-ranked 500 PCBC 6.226E-6 4.248E-4 3.538E-3 1.448E-2 10 495
34 Facebase RNAseq ratio e9.5 MandibularArch vs MaxillaryArch 1000 K2 FacebaseRNAseq ratio e9.5 MandibularArch vs MaxillaryArch top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 6.381E-6 4.248E-4 3.538E-3 1.484E-2 8 292
35 gudmap dev gonad e12.5 F VasAssMesen MafB 500 dev gonad e12.5 F VasAssMesen MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.392E-6 4.248E-4 3.538E-3 1.487E-2 9 389
36 gudmap dev gonad e11.5 M GonadVasMes Flk k4 500 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.625E-6 4.281E-4 3.565E-3 1.541E-2 7 208
37 PCBC ratio SC-LF blastocyst vs SC blastocyst cfr-2X-p05 SC-LF blastocyst vs SC blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 7.378E-6 4.638E-4 3.863E-3 1.716E-2 9 396
38 gudmap developingKidney e15.5 Peripheral blastema 200 k5 DevelopingKidney e15.5 Peripheral blastema emap-27731 k-means-cluster#5 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 8.001E-6 4.897E-4 4.079E-3 1.861E-2 3 12
39 PCBC ratio EB blastocyst vs EB amniotic fluid MSC cfr-2X-p05 EB blastocyst vs EB amniotic fluid MSC-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 8.357E-6 4.984E-4 4.152E-3 1.944E-2 8 303
40 gudmap kidney e15.5 Podocyte MafB 100 kidney e15.5 Podocyte MafB top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 8.586E-6 4.993E-4 4.159E-3 1.997E-2 5 82
41 JC hmvEC 500 K1 JC hmvEC top-relative-expression-ranked 500 k-means-cluster#1 PCBC 9.555E-6 5.421E-4 4.515E-3 2.222E-2 7 220
42 gudmap dev gonad e11.5 M GonMes Sma k3 1000 dev gonad e11.5 M GonMes Sma k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.034E-5 5.697E-4 4.745E-3 2.405E-2 8 312
43 gudmap dev gonad e12.5 F VasAssMesen MafB k4 500 dev gonad e12.5 F VasAssMesen MafB k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.053E-5 5.697E-4 4.745E-3 2.450E-2 6 147
44 gudmap developingKidney e15.5 Peripheral blastema 500 DevelopingKidney e15.5 Peripheral blastema emap-27731 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.204E-5 6.363E-4 5.300E-3 2.800E-2 9 421
45 GSM538282 500 Myeloid Cells, MF.Lu, CD11chi CD11b- CD103- MHCII- SiglecF+, Lung, avg-3 Immgen.org, GSE15907 1.298E-5 6.707E-4 5.587E-3 3.018E-2 9 425
46 gudmap dev gonad e11.5 F GonMes Sma k4 1000 dev gonad e11.5 F GonMes Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.484E-5 7.446E-4 6.202E-3 3.453E-2 8 328
47 gudmap dev gonad e11.5 M GonMes Sma 500 dev gonad e11.5 M GonMes Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.505E-5 7.446E-4 6.202E-3 3.500E-2 9 433
48 Facebase RNAseq e9.5 Facial Mesenchyne 500 K3 FacebaseRNAseq e9.5 Facial Mesenchyne top-relative-expression-ranked 500 k-means-cluster#3 FaceBase_RNAseq 1.706E-5 8.187E-4 6.819E-3 3.969E-2 6 160
49 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma k1 1000 dev gonad e13.5 F VascAssocMesenchStromOvary Sma k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.725E-5 8.187E-4 6.819E-3 4.011E-2 7 241
50 GSM777046 100 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 1.950E-5 9.071E-4 7.556E-3 4.536E-2 5 97
Show 45 more annotations

15: Computational [Display Chart] 219 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 44 Genes in module 44 MSigDb: C4 - CM: Cancer Modules 3.296E-4 3.686E-2
2.200E-1
7.219E-2
 8 319
2 module 212 Genes in module 212 MSigDb: C4 - CM: Cancer Modules 3.367E-4 3.686E-2
2.200E-1
7.373E-2
 8 320
3 module 15 Genes in module 15 MSigDb: C4 - CM: Cancer Modules 6.121E-4 4.468E-2
2.667E-1
1.341E-1
 8 350

16: MicroRNA [Display Chart] 991 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-211:PITA hsa-miR-211:PITA TOP PITA 4.104E-7 2.034E-4 1.520E-3 4.067E-4 11 431
2 hsa-miR-204:PITA hsa-miR-204:PITA TOP PITA 4.104E-7 2.034E-4 1.520E-3 4.067E-4 11 431
3 hsa-miR-877:PITA hsa-miR-877:PITA TOP PITA 5.898E-5 1.566E-2
1.171E-1
5.845E-2
 5 114
4 AAAGGGA,MIR-211:MSigDB AAAGGGA,MIR-211:MSigDB MSigDB 1.173E-4 1.566E-2
1.171E-1
1.162E-1
 6 211
5 AAAGGGA,MIR-204:MSigDB AAAGGGA,MIR-204:MSigDB MSigDB 1.173E-4 1.566E-2
1.171E-1
1.162E-1
 6 211
6 hsa-miR-1237:PITA hsa-miR-1237:PITA TOP PITA 1.267E-4 1.566E-2
1.171E-1
1.255E-1
 6 214
7 hsa-miR-7:miRecords TarBase hsa-miR-7:miRecords TarBase miRecords_TarBase 1.289E-4 1.566E-2
1.171E-1
1.277E-1
 2 5
8 hsa-miR-1256:PITA hsa-miR-1256:PITA TOP PITA 1.956E-4 1.566E-2
1.171E-1
1.938E-1
 5 147
9 hsa-miR-374b:TargetScan hsa-miR-374b:TargetScan TargetScan 2.488E-4 1.566E-2
1.171E-1
2.465E-1
 8 458
10 hsa-miR-374a:TargetScan hsa-miR-374a:TargetScan TargetScan 2.488E-4 1.566E-2
1.171E-1
2.465E-1
 8 458
11 hsa-miR-204:miRTarbase hsa-miR-204:miRTarbase miRTarbase 2.528E-4 1.566E-2
1.171E-1
2.505E-1
 3 34
12 hsa-miR-204:TargetScan hsa-miR-204:TargetScan TargetScan 2.600E-4 1.566E-2
1.171E-1
2.576E-1
 8 461
13 hsa-miR-211:TargetScan hsa-miR-211:TargetScan TargetScan 2.600E-4 1.566E-2
1.171E-1
2.576E-1
 8 461
14 hsa-miR-449a:TargetScan hsa-miR-449a:TargetScan TargetScan 2.919E-4 1.566E-2
1.171E-1
2.892E-1
 8 469
15 hsa-miR-34a:TargetScan hsa-miR-34a:TargetScan TargetScan 2.919E-4 1.566E-2
1.171E-1
2.892E-1
 8 469
16 hsa-miR-34c-5p:TargetScan hsa-miR-34c-5p:TargetScan TargetScan 2.919E-4 1.566E-2
1.171E-1
2.892E-1
 8 469
17 hsa-miR-449b:TargetScan hsa-miR-449b:TargetScan TargetScan 2.919E-4 1.566E-2
1.171E-1
2.892E-1
 8 469
18 hsa-miR-145:miRTarbase hsa-miR-145:miRTarbase miRTarbase 2.951E-4 1.566E-2
1.171E-1
2.925E-1
 4 88
19 hsa-miR-421:PITA hsa-miR-421:PITA TOP PITA 3.002E-4 1.566E-2
1.171E-1
2.975E-1
 7 355
20 miR-181c:PicTar miR-181c:PicTar PicTar 4.471E-4 2.216E-2
1.656E-1
4.431E-1
 8 500
21 hsa-miR-382:PITA hsa-miR-382:PITA TOP PITA 4.966E-4 2.344E-2
1.752E-1
4.922E-1
 6 276
22 hsa-miR-592:PITA hsa-miR-592:PITA TOP PITA 7.312E-4 3.294E-2
2.463E-1
7.246E-1
 5 196
23 hsa-miR-516a-3p:PITA hsa-miR-516a-3p:PITA TOP PITA 1.039E-3 4.478E-2
3.348E-1
1.000E0
 5 212
24 hsa-miR-7:miRTarbase hsa-miR-7:miRTarbase miRTarbase 1.149E-3 4.605E-2
3.443E-1
1.000E0
 2 14
25 hsa-miR-615-5p:mirSVR highEffct hsa-miR-615-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.162E-3 4.605E-2
3.443E-1
1.000E0
 6 325
26 hsa-miR-548m:PITA hsa-miR-548m:PITA TOP PITA 1.331E-3 4.874E-2
3.644E-1
1.000E0
 7 457
27 miR-369-3p:PicTar miR-369-3p:PicTar PicTar 1.356E-3 4.874E-2
3.644E-1
1.000E0
 6 335
28 miR-141:PicTar miR-141:PicTar PicTar 1.377E-3 4.874E-2
3.644E-1
1.000E0
 6 336
Show 23 more annotations

17: Drug [Display Chart] 15222 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 486 UP calmidazolium chloride; Up 200; 5uM; MCF7; HG-U133A Broad Institute CMAP 1.474E-10 2.244E-6 2.290E-5 2.244E-6 10 165
2 D019308 Palmitic Acid CTD 1.351E-9 1.028E-5 1.050E-4 2.057E-5 8 101
3 D016566 Organoselenium Compounds CTD 3.257E-9 1.402E-5 1.431E-4 4.957E-5 7 71
4 D017258 Medroxyprogesterone Acetate CTD 4.569E-9 1.402E-5 1.431E-4 6.955E-5 12 390
5 5248 UP Phenoxybenzamine hydrochloride [63-92-3]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP 5.257E-9 1.402E-5 1.431E-4 8.002E-5 9 174
6 1746 UP Mometasone furoate [83919-23-7]; Up 200; 7.6uM; HL60; HG-U133A Broad Institute CMAP 5.528E-9 1.402E-5 1.431E-4 8.414E-5 9 175
7 6764 UP Anisomycin [22862-76-6]; Up 200; 15uM; PC3; HT HG-U133A Broad Institute CMAP 4.419E-8 9.609E-5 9.809E-4 6.726E-4 8 157
8 1234 UP Trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 7.135E-8 1.323E-4 1.351E-3 1.086E-3 8 167
9 5724 UP Mefloquine hydrochloride [51773-92-3]; Up 200; 9.6uM; PC3; HT HG-U133A Broad Institute CMAP 7.824E-8 1.323E-4 1.351E-3 1.191E-3 8 169
10 MESH:D011471/D004958-M Prostatic Neoplasms affected by Estradiol CTD Marker 1.637E-7 2.361E-4 2.410E-3 2.492E-3 8 186
11 4457 DN rosiglitazone; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 1.706E-7 2.361E-4 2.410E-3 2.597E-3 8 187
12 C037123 cadmium sulfate CTD 4.334E-7 5.498E-4 5.612E-3 6.598E-3 9 291
13 MESH:D011471/D001564-M Prostatic Neoplasms affected by Benzo(a)pyrene CTD Marker 6.145E-7 6.831E-4 6.972E-3 9.354E-3 7 151
14 MESH:D011471/D004317-T Prostatic Neoplasms affected by Doxorubicin CTD Therapeutic 6.282E-7 6.831E-4 6.972E-3 9.563E-3 6 94
15 1520 UP Azacyclonol [115-46-8]; Up 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 7.018E-7 7.122E-4 7.270E-3 1.068E-2 7 154
16 2651 UP Suloctidil [54063-56-8]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP 7.992E-7 7.603E-4 7.761E-3 1.217E-2 7 157
17 1220 UP SAHA; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 9.077E-7 8.090E-4 8.258E-3 1.382E-2 7 160
18 D001379 Azathioprine CTD 9.868E-7 8.090E-4 8.258E-3 1.502E-2 7 162
19 D002857 Chromium CTD 1.098E-6 8.090E-4 8.258E-3 1.672E-2 8 239
20 3770 UP Helveticoside [630-64-8]; Up 200; 7.4uM; PC3; HT HG-U133A Broad Institute CMAP 1.116E-6 8.090E-4 8.258E-3 1.699E-2 7 165
21 3275 UP Digitoxigenin [143-62-4]; Up 200; 10.6uM; MCF7; HT HG-U133A Broad Institute CMAP 1.116E-6 8.090E-4 8.258E-3 1.699E-2 7 165
22 6087 UP Strophanthidin [66-28-4]; Up 200; 9.8uM; MCF7; HT HG-U133A Broad Institute CMAP 1.259E-6 8.311E-4 8.483E-3 1.917E-2 7 168
23 1132 UP BW-B 70C; Up 200; 31.6uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.310E-6 8.311E-4 8.483E-3 1.995E-2 7 169
24 1793 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.310E-6 8.311E-4 8.483E-3 1.995E-2 7 169
25 CID011947681 nitroprusside Stitch 1.673E-6 9.494E-4 9.692E-3 2.546E-2 6 111
26 6439 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 1.718E-6 9.494E-4 9.692E-3 2.616E-2 7 176
27 7555 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 1.785E-6 9.494E-4 9.692E-3 2.716E-2 7 177
28 2048 UP Mefloquine hydrochloride [51773-92-3]; Up 200; 9.6uM; PC3; HT HG-U133A Broad Institute CMAP 1.853E-6 9.494E-4 9.692E-3 2.820E-2 7 178
29 839 UP 5224221; Up 200; 12uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.923E-6 9.494E-4 9.692E-3 2.928E-2 7 179
30 5489 UP Prenylamine lactate [69-43-2]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP 1.923E-6 9.494E-4 9.692E-3 2.928E-2 7 179
31 5950 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 1.996E-6 9.494E-4 9.692E-3 3.038E-2 7 180
32 4652 UP Phenoxybenzamine hydrochloride [63-92-3]; Up 200; 11.8uM; PC3; HT HG-U133A Broad Institute CMAP 1.996E-6 9.494E-4 9.692E-3 3.038E-2 7 180
33 5822 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 2.071E-6 9.552E-4 9.751E-3 3.152E-2 7 181
34 4610 DN Doxorubicin hydrochloride [25316-40-9]; Down 200; 6.8uM; PC3; HT HG-U133A Broad Institute CMAP 2.310E-6 1.005E-3 1.026E-2 3.516E-2 7 184
35 3691 DN 0175029-0000 [211245-78-2]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 2.310E-6 1.005E-3 1.026E-2 3.516E-2 7 184
36 7511 DN daunorubicin HCl; Down 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 2.572E-6 1.022E-3 1.043E-2 3.915E-2 7 187
37 6709 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 2.572E-6 1.022E-3 1.043E-2 3.915E-2 7 187
38 5420 UP Hexetidine [141-94-6]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP 2.572E-6 1.022E-3 1.043E-2 3.915E-2 7 187
39 C040641 genistin CTD 2.747E-6 1.022E-3 1.043E-2 4.181E-2 3 9
40 1369 UP Disulfiram [97-77-8]; Up 200; 13.4uM; HL60; HG-U133A Broad Institute CMAP 2.760E-6 1.022E-3 1.043E-2 4.201E-2 7 189
41 3084 UP Clioquinol [130-26-7]; Up 200; 13uM; HL60; HT HG-U133A Broad Institute CMAP 2.760E-6 1.022E-3 1.043E-2 4.201E-2 7 189
42 5942 UP LY294002; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 2.858E-6 1.022E-3 1.043E-2 4.350E-2 7 190
43 C001277 geldanamycin CTD 2.886E-6 1.022E-3 1.043E-2 4.394E-2 9 366
44 1663 UP ICI 182,780; Up 200; 0.01uM; MCF7; HT HG-U133A Broad Institute CMAP 2.959E-6 1.024E-3 1.045E-2 4.504E-2 7 191
45 5729 UP Disulfiram [97-77-8]; Up 200; 13.4uM; PC3; HT HG-U133A Broad Institute CMAP 3.063E-6 1.036E-3 1.058E-2 4.663E-2 7 192
46 4619 DN Ritodrine hydrochloride [23239-51-2]; Down 200; 12.4uM; PC3; HT HG-U133A Broad Institute CMAP 3.510E-6 1.162E-3 1.186E-2
5.344E-2
 7 196
47 3563 DN Estriol [50-27-1]; Down 200; 13.8uM; MCF7; HT HG-U133A Broad Institute CMAP 3.881E-6 1.257E-3 1.283E-2
5.907E-2
 7 199
48 CID000005213 silibinin Stitch 4.064E-6 1.289E-3 1.316E-2
6.187E-2
 8 285
49 C010063 carbonyl sulfide CTD 4.999E-6 1.553E-3 1.585E-2
7.610E-2
 6 134
50 CID000119173 MeOBGDTC Stitch 5.371E-6 1.618E-3 1.652E-2
8.175E-2
 3 11
Show 45 more annotations

18: Disease [Display Chart] 1528 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0020456 Hyperglycemia DisGeNET Curated 6.655E-8 1.017E-4 8.043E-4 1.017E-4 12 400
2 umls:C0410702 Adolescent idiopathic scoliosis DisGeNET BeFree 1.052E-6 8.037E-4 6.357E-3 1.607E-3 5 45
3 umls:C1519670 Tumor Angiogenesis DisGeNET BeFree 1.612E-6 8.212E-4 6.495E-3 2.463E-3 11 443
4 cv:C0011860 Diabetes mellitus type 2 Clinical Variations 4.838E-6 1.848E-3 1.462E-2 7.392E-3 4 28
5 umls:C0085207 Gestational Diabetes DisGeNET Curated 8.819E-6 2.591E-3 2.049E-2 1.348E-2 7 181
6 125853 DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM OMIM 1.076E-5 2.591E-3 2.049E-2 1.644E-2 4 34
7 umls:C3714542 Lymphoma, Diffuse DisGeNET BeFree 1.211E-5 2.591E-3 2.049E-2 1.850E-2 4 35
8 umls:C0282612 Prostatic Intraepithelial Neoplasias DisGeNET Curated 1.357E-5 2.591E-3 2.049E-2 2.073E-2 6 128
9 umls:C0853879 Invasive breast carcinoma DisGeNET BeFree 1.806E-5 3.066E-3 2.425E-2 2.759E-2 9 369
10 umls:C0153690 Secondary malignant neoplasm of bone DisGeNET BeFree 2.121E-5 3.241E-3 2.563E-2 3.241E-2 8 287
11 umls:C0029928 Ovarian Diseases DisGeNET Curated 4.252E-5 5.484E-3 4.337E-2
6.497E-2
 7 231
12 umls:C0151650 Renal fibrosis DisGeNET BeFree 4.307E-5 5.484E-3 4.337E-2
6.581E-2
 6 157
13 umls:C1862939 AMYOTROPHIC LATERAL SCLEROSIS 1 DisGeNET Curated 5.878E-5 6.634E-3
5.247E-2
8.982E-2
 6 166
14 umls:C0339573 Glaucoma, Primary Open Angle DisGeNET Curated 6.078E-5 6.634E-3
5.247E-2
9.287E-2
 6 167
15 umls:C0333516 Tumor necrosis DisGeNET BeFree 6.710E-5 6.835E-3
5.406E-2
1.025E-1
 6 170
16 umls:C0395866 Recurrent acute otitis media DisGeNET BeFree 9.817E-5 9.376E-3
7.415E-2
1.500E-1
 2 4
17 umls:C0035412 Rhabdomyosarcoma DisGeNET Curated 1.049E-4 9.431E-3
7.459E-2
1.603E-1
 8 360
18 umls:C3714524 Fibromyxosarcoma DisGeNET BeFree 1.406E-4 1.194E-2
9.440E-2
2.148E-1
 3 25
19 umls:C0342642 Autosomal dominant hypophosphatemic rickets DisGeNET Curated 1.632E-4 1.247E-2
9.861E-2
2.494E-1
 2 5
20 umls:C1852091 INSULIN RESISTANCE, SUSCEPTIBILITY TO DisGeNET Curated 1.632E-4 1.247E-2
9.861E-2
2.494E-1
 2 5
21 umls:C0497406 Overweight DisGeNET Curated 1.925E-4 1.372E-2
1.085E-1
2.941E-1
 6 206
22 umls:C2936349 Plaque, Amyloid DisGeNET Curated 1.976E-4 1.372E-2
1.085E-1
3.019E-1
 6 207
23 umls:C0014599 Epithelial hyperplasia DisGeNET BeFree 2.208E-4 1.467E-2
1.160E-1
3.373E-1
 3 29
24 umls:C0151744 Myocardial Ischemia DisGeNET Curated 2.682E-4 1.708E-2
1.351E-1
4.099E-1
 8 413
25 umls:C0038580 Substance Dependence DisGeNET Curated 3.036E-4 1.856E-2
1.468E-1
4.639E-1
 4 79
26 umls:C0699744 Infection of ear DisGeNET BeFree 3.409E-4 1.868E-2
1.478E-1
5.209E-1
 2 7
27 umls:C0029877 Ear Inflammation DisGeNET BeFree 3.409E-4 1.868E-2
1.478E-1
5.209E-1
 2 7
28 umls:C0005940 Bone Diseases DisGeNET Curated 3.552E-4 1.868E-2
1.478E-1
5.427E-1
 5 149
29 umls:C0022336 Creutzfeldt-Jakob disease DisGeNET Curated 3.668E-4 1.868E-2
1.478E-1
5.605E-1
 4 83
30 umls:C0920646 Renal ischaemia DisGeNET BeFree 3.668E-4 1.868E-2
1.478E-1
5.605E-1
 4 83
31 umls:C0238463 Papillary thyroid carcinoma DisGeNET Curated 4.485E-4 2.165E-2
1.712E-1
6.853E-1
 8 446
32 umls:C0342953 Organ dysfunction syndrome DisGeNET BeFree 4.533E-4 2.165E-2
1.712E-1
6.927E-1
 2 8
33 umls:C0278488 Carcinoma breast stage IV DisGeNET BeFree 4.705E-4 2.178E-2
1.723E-1
7.189E-1
 7 341
34 umls:C0342643 Autosomal recessive hypophosphatemic vitamin D refractory rickets DisGeNET Curated 5.813E-4 2.538E-2
2.007E-1
8.882E-1
 2 9
35 umls:C1865343 OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENT OF SPINE DisGeNET Curated 5.813E-4 2.538E-2
2.007E-1
8.882E-1
 2 9
36 umls:C1512409 Hepatocarcinogenesis DisGeNET BeFree 6.425E-4 2.693E-2
2.130E-1
9.817E-1
 8 471
37 umls:C0079772 T-Cell Lymphoma DisGeNET Curated 6.522E-4 2.693E-2
2.130E-1
9.965E-1
 6 259
38 umls:C1619692 Nephrogenic Fibrosing Dermopathy DisGeNET Curated 7.247E-4 2.914E-2
2.305E-1
1.000E0
 2 10
39 umls:C0028756 Obesity, Morbid DisGeNET Curated 7.715E-4 3.023E-2
2.391E-1
1.000E0
 4 101
40 umls:C0271650 Impaired glucose tolerance DisGeNET Curated 8.103E-4 3.095E-2
2.448E-1
1.000E0
 6 270
41 umls:C1368683 Epithelioma DisGeNET BeFree 9.082E-4 3.382E-2
2.675E-1
1.000E0
 6 276
42 umls:C0011882 Diabetic Neuropathies DisGeNET Curated 9.296E-4 3.382E-2
2.675E-1
1.000E0
 3 47
43 umls:C3714619 Insulin resistance syndrome DisGeNET BeFree 9.887E-4 3.512E-2
2.778E-1
1.000E0
 3 48
44 umls:C0030552 Paresis DisGeNET Curated 1.026E-3 3.512E-2
2.778E-1
1.000E0
 4 109
45 umls:C0022577 Keratoconjunctivitis, Vernal DisGeNET BeFree 1.057E-3 3.512E-2
2.778E-1
1.000E0
 2 12
46 umls:C0342541 Precocious pubarche DisGeNET BeFree 1.057E-3 3.512E-2
2.778E-1
1.000E0
 2 12
47 umls:C0002726 Amyloidosis DisGeNET Curated 1.173E-3 3.813E-2
3.016E-1
1.000E0
 4 113
48 umls:C0281361 Adenocarcinoma of pancreas DisGeNET BeFree 1.620E-3 3.831E-2
3.030E-1
1.000E0
 6 309
49 umls:C0206624 Hepatoblastoma DisGeNET Curated 1.665E-3 3.831E-2
3.030E-1
1.000E0
 5 210
50 umls:C0025306 Meningococcemia DisGeNET BeFree 1.669E-3 3.831E-2
3.030E-1
1.000E0
 2 15
Show 45 more annotations