Toppgene analysis for aggregated_1964_log, IC15, negative side

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1: GO: Molecular Function [Display Chart] 454 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0050839 cell adhesion molecule binding 1.672E-6 4.199E-4 2.812E-3 7.589E-4 10 209
2 GO:0005178 integrin binding 1.850E-6 4.199E-4 2.812E-3 8.398E-4 8 122
3 GO:1901681 sulfur compound binding 1.158E-5 1.752E-3 1.173E-2 5.257E-3 10 260
4 GO:0008201 heparin binding 1.884E-5 2.138E-3 1.432E-2 8.554E-3 8 167
5 GO:0001968 fibronectin binding 7.171E-5 6.511E-3 4.360E-2 3.256E-2 4 33
6 GO:0005539 glycosaminoglycan binding 1.279E-4 8.481E-3
5.679E-2
5.809E-2
 8 219
7 GO:0005518 collagen binding 1.308E-4 8.481E-3
5.679E-2
5.937E-2
 5 72
8 GO:0001105 RNA polymerase II transcription coactivator activity 1.702E-4 9.437E-3
6.320E-2
7.725E-2
 4 41
9 GO:0048365 Rac GTPase binding 1.871E-4 9.437E-3
6.320E-2
8.494E-2
 4 42
10 GO:0017048 Rho GTPase binding 3.184E-4 1.445E-2
9.679E-2
1.445E-1
 5 87
11 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding 4.234E-4 1.514E-2
1.014E-1
1.922E-1
 6 142
12 GO:0019838 growth factor binding 4.234E-4 1.514E-2
1.014E-1
1.922E-1
 6 142
13 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding 4.335E-4 1.514E-2
1.014E-1
1.968E-1
 5 93
14 GO:0001104 RNA polymerase II transcription cofactor activity 5.017E-4 1.627E-2
1.089E-1
2.278E-1
 5 96
15 GO:0030023 extracellular matrix constituent conferring elasticity 6.763E-4 1.858E-2
1.244E-1
3.071E-1
 2 6
16 GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding 6.959E-4 1.858E-2
1.244E-1
3.159E-1
 4 59
17 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding 6.959E-4 1.858E-2
1.244E-1
3.159E-1
 4 59
18 GO:0004714 transmembrane receptor protein tyrosine kinase activity 1.124E-3 2.835E-2
1.898E-1
5.103E-1
 4 67
19 GO:0038036 sphingosine-1-phosphate receptor activity 1.251E-3 2.840E-2
1.902E-1
5.681E-1
 2 8
20 GO:0097493 structural molecule activity conferring elasticity 1.251E-3 2.840E-2
1.902E-1
5.681E-1
 2 8
21 GO:0016597 amino acid binding 1.589E-3 3.435E-2
2.300E-1
7.214E-1
 5 124
22 GO:0003779 actin binding 2.041E-3 4.212E-2
2.821E-1
9.267E-1
 9 412
23 GO:0046790 virion binding 2.425E-3 4.787E-2
3.206E-1
1.000E0
 2 11
Show 18 more annotations

2: GO: Biological Process [Display Chart] 3118 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001525 angiogenesis 6.307E-12 1.966E-8 1.695E-7 1.966E-8 21 465
2 GO:0030198 extracellular matrix organization 2.487E-9 2.692E-6 2.321E-5 7.755E-6 16 354
3 GO:0043062 extracellular structure organization 2.590E-9 2.692E-6 2.321E-5 8.075E-6 16 355
4 GO:0071559 response to transforming growth factor beta 7.833E-9 6.106E-6 5.265E-5 2.442E-5 13 235
5 GO:0090287 regulation of cellular response to growth factor stimulus 1.858E-7 1.159E-4 9.992E-4 5.794E-4 12 256
6 GO:0050678 regulation of epithelial cell proliferation 3.605E-7 1.434E-4 1.236E-3 1.124E-3 13 326
7 GO:0030335 positive regulation of cell migration 3.871E-7 1.434E-4 1.236E-3 1.207E-3 15 446
8 GO:0050673 epithelial cell proliferation 5.041E-7 1.434E-4 1.236E-3 1.572E-3 14 394
9 GO:0071560 cellular response to transforming growth factor beta stimulus 5.279E-7 1.434E-4 1.236E-3 1.646E-3 11 231
10 GO:2000147 positive regulation of cell motility 5.567E-7 1.434E-4 1.236E-3 1.736E-3 15 459
11 GO:0010464 regulation of mesenchymal cell proliferation 5.828E-7 1.434E-4 1.236E-3 1.817E-3 6 45
12 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 5.978E-7 1.434E-4 1.236E-3 1.864E-3 8 105
13 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 5.978E-7 1.434E-4 1.236E-3 1.864E-3 8 105
14 GO:0051272 positive regulation of cellular component movement 7.700E-7 1.604E-4 1.383E-3 2.401E-3 15 471
15 GO:0007517 muscle organ development 8.105E-7 1.604E-4 1.383E-3 2.527E-3 14 410
16 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 8.538E-7 1.604E-4 1.383E-3 2.662E-3 8 110
17 GO:0040017 positive regulation of locomotion 9.261E-7 1.604E-4 1.383E-3 2.888E-3 15 478
18 GO:0007409 axonogenesis 9.261E-7 1.604E-4 1.383E-3 2.888E-3 15 478
19 GO:0071772 response to BMP 1.856E-6 2.894E-4 2.495E-3 5.787E-3 9 164
20 GO:0071773 cellular response to BMP stimulus 1.856E-6 2.894E-4 2.495E-3 5.787E-3 9 164
21 GO:0010463 mesenchymal cell proliferation 2.185E-6 3.184E-4 2.745E-3 6.814E-3 6 56
22 GO:0031589 cell-substrate adhesion 2.246E-6 3.184E-4 2.745E-3 7.004E-3 12 324
23 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 3.040E-6 4.121E-4 3.554E-3 9.479E-3 10 223
24 GO:0050679 positive regulation of epithelial cell proliferation 3.482E-6 4.523E-4 3.900E-3 1.086E-2 9 177
25 GO:0090288 negative regulation of cellular response to growth factor stimulus 4.005E-6 4.995E-4 4.307E-3 1.249E-2 8 135
26 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 4.414E-6 5.249E-4 4.526E-3 1.376E-2 12 346
27 GO:0001667 ameboidal-type cell migration 4.546E-6 5.249E-4 4.526E-3 1.417E-2 12 347
28 GO:0002053 positive regulation of mesenchymal cell proliferation 4.970E-6 5.534E-4 4.772E-3 1.550E-2 5 37
29 GO:0001655 urogenital system development 6.243E-6 6.489E-4 5.595E-3 1.947E-2 12 358
30 GO:0048145 regulation of fibroblast proliferation 6.243E-6 6.489E-4 5.595E-3 1.947E-2 7 102
31 GO:0048146 positive regulation of fibroblast proliferation 6.891E-6 6.890E-4 5.941E-3 2.149E-2 6 68
32 GO:0010975 regulation of neuron projection development 7.071E-6 6.890E-4 5.941E-3 2.205E-2 14 494
33 GO:0048048 embryonic eye morphogenesis 7.381E-6 6.938E-4 5.983E-3 2.301E-2 5 40
34 GO:0048144 fibroblast proliferation 7.566E-6 6.938E-4 5.983E-3 2.359E-2 7 105
35 GO:0010595 positive regulation of endothelial cell migration 8.868E-6 7.887E-4 6.801E-3 2.765E-2 6 71
36 GO:0030509 BMP signaling pathway 9.167E-6 7.887E-4 6.801E-3 2.858E-2 8 151
37 GO:0072001 renal system development 9.360E-6 7.887E-4 6.801E-3 2.918E-2 11 311
38 GO:0010634 positive regulation of epithelial cell migration 1.028E-5 8.439E-4 7.276E-3 3.207E-2 7 110
39 GO:0060541 respiratory system development 1.100E-5 8.792E-4 7.580E-3 3.429E-2 10 258
40 GO:0072091 regulation of stem cell proliferation 1.300E-5 1.014E-3 8.739E-3 4.054E-2 7 114
41 GO:0048483 autonomic nervous system development 1.334E-5 1.014E-3 8.744E-3 4.158E-2 5 45
42 GO:2000648 positive regulation of stem cell proliferation 1.646E-5 1.186E-3 1.023E-2
5.133E-2
 6 79
43 GO:0030514 negative regulation of BMP signaling pathway 1.656E-5 1.186E-3 1.023E-2
5.164E-2
 5 47
44 GO:0043542 endothelial cell migration 1.674E-5 1.186E-3 1.023E-2
5.219E-2
 8 164
45 GO:0001503 ossification 2.194E-5 1.520E-3 1.310E-2
6.839E-2
 12 406
46 GO:0032092 positive regulation of protein binding 2.342E-5 1.587E-3 1.369E-2
7.301E-2
 6 84
47 GO:0051592 response to calcium ion 2.761E-5 1.832E-3 1.579E-2
8.609E-2
 7 128
48 GO:0030510 regulation of BMP signaling pathway 2.861E-5 1.858E-3 1.602E-2
8.921E-2
 6 87
49 GO:0001822 kidney development 3.281E-5 2.064E-3 1.780E-2
1.023E-1
 10 293
50 GO:0010631 epithelial cell migration 3.376E-5 2.064E-3 1.780E-2
1.053E-1
 9 235
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 272 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031012 extracellular matrix 5.081E-8 6.130E-6 3.791E-5 1.382E-5 16 444
2 GO:0005925 focal adhesion 6.498E-8 6.130E-6 3.791E-5 1.768E-5 15 393
3 GO:0005924 cell-substrate adherens junction 7.663E-8 6.130E-6 3.791E-5 2.084E-5 15 398
4 GO:0030055 cell-substrate junction 9.014E-8 6.130E-6 3.791E-5 2.452E-5 15 403
5 GO:0005578 proteinaceous extracellular matrix 2.731E-7 1.485E-5 9.187E-5 7.427E-5 14 379
6 GO:0005912 adherens junction 9.303E-7 4.217E-5 2.608E-4 2.530E-4 15 484
7 GO:0030426 growth cone 3.243E-5 1.260E-3 7.793E-3 8.820E-3 8 182
8 GO:0030427 site of polarized growth 3.933E-5 1.337E-3 8.271E-3 1.070E-2 8 187
9 GO:0044420 extracellular matrix component 5.192E-5 1.569E-3 9.705E-3 1.412E-2 7 143
10 GO:0005938 cell cortex 8.237E-5 2.241E-3 1.386E-2 2.241E-2 9 267
11 GO:0031091 platelet alpha granule 1.510E-4 3.735E-3 2.310E-2 4.108E-2 5 75
12 GO:0099568 cytoplasmic region 3.655E-4 8.168E-3
5.051E-2
9.943E-2
 9 326
13 GO:0015629 actin cytoskeleton 3.904E-4 8.168E-3
5.051E-2
1.062E-1
 11 478
14 GO:0005884 actin filament 4.780E-4 9.288E-3
5.744E-2
1.300E-1
 5 96
15 GO:0005911 cell-cell junction 5.546E-4 1.006E-2
6.220E-2
1.508E-1
 10 420
16 GO:0030016 myofibril 7.487E-4 1.273E-2
7.872E-2
2.037E-1
 7 221
17 GO:0005604 basement membrane 9.252E-4 1.480E-2
9.155E-2
2.516E-1
 5 111
18 GO:0043292 contractile fiber 1.072E-3 1.553E-2
9.602E-2
2.915E-1
 7 235
19 GO:0005923 bicellular tight junction 1.084E-3 1.553E-2
9.602E-2
2.950E-1
 5 115
20 GO:0070160 occluding junction 1.217E-3 1.655E-2
1.023E-1
3.309E-1
 5 118
21 GO:0031252 cell leading edge 1.282E-3 1.661E-2
1.027E-1
3.488E-1
 9 389
22 GO:0030027 lamellipodium 1.632E-3 2.018E-2
1.248E-1
4.440E-1
 6 186
23 GO:0043296 apical junction complex 1.931E-3 2.212E-2
1.368E-1
5.253E-1
 5 131
24 GO:0001527 microfibril 1.951E-3 2.212E-2
1.368E-1
5.308E-1
 2 10
25 GO:0043209 myelin sheath 2.596E-3 2.824E-2
1.747E-1
7.060E-1
 6 204
26 GO:0098858 actin-based cell projection 2.725E-3 2.850E-2
1.763E-1
7.411E-1
 6 206
27 GO:0030667 secretory granule membrane 3.073E-3 3.095E-2
1.914E-1
8.358E-1
 4 89
28 GO:0031092 platelet alpha granule membrane 3.338E-3 3.243E-2
2.006E-1
9.079E-1
 2 13
29 GO:0019897 extrinsic component of plasma membrane 3.672E-3 3.444E-2
2.130E-1
9.987E-1
 5 152
30 GO:0030863 cortical cytoskeleton 4.185E-3 3.794E-2
2.347E-1
1.000E0
 4 97
31 GO:0031225 anchored component of membrane 4.563E-3 4.004E-2
2.476E-1
1.000E0
 5 160
32 GO:0030175 filopodium 5.002E-3 4.177E-2
2.584E-1
1.000E0
 4 102
33 GO:0005614 interstitial matrix 5.068E-3 4.177E-2
2.584E-1
1.000E0
 2 16
34 GO:0044853 plasma membrane raft 5.541E-3 4.433E-2
2.742E-1
1.000E0
 4 105
35 GO:0031093 platelet alpha granule lumen 6.050E-3 4.702E-2
2.908E-1
1.000E0
 3 55
36 GO:0042568 insulin-like growth factor binary complex 6.729E-3 4.946E-2
3.059E-1
1.000E0
 1 1
37 GO:0044228 host cell surface 6.729E-3 4.946E-2
3.059E-1
1.000E0
 1 1
Show 32 more annotations

4: Human Phenotype [Display Chart] 840 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0001783 Broad metatarsal 2.079E-5 1.517E-2
1.109E-1
 1.746E-2 3 6
2 HP:0001230 Broad metacarpals 3.612E-5 1.517E-2
1.109E-1
 3.034E-2 3 7
3 HP:0002987 Elbow flexion contracture 7.924E-5 1.531E-2
1.119E-1
6.657E-2
 5 44
4 HP:0006086 Thin metacarpal cortices 1.065E-4 1.531E-2
1.119E-1
8.943E-2
 2 2
5 HP:0001704 Tricuspid valve prolapse 1.065E-4 1.531E-2
1.119E-1
8.943E-2
 2 2
6 HP:0001166 Arachnodactyly 1.093E-4 1.531E-2
1.119E-1
9.185E-2
 5 47
7 HP:0002097 Emphysema 1.653E-4 1.984E-2
1.451E-1
1.389E-1
 3 11
8 HP:0009768 Broad phalanges of the hand 3.173E-4 3.331E-2
2.436E-1
2.665E-1
 2 3
9 HP:0010049 Short metacarpal 3.804E-4 3.381E-2
2.472E-1
3.195E-1
 5 61
10 HP:0003196 Short nose {has synonym type="layperson"} 4.066E-4 3.381E-2
2.472E-1
3.415E-1
 7 134
11 HP:0006466 Ankle contracture 4.428E-4 3.381E-2
2.472E-1
3.719E-1
 3 15
12 HP:0001059 Pterygium 6.303E-4 3.917E-2
2.864E-1
5.294E-1
 2 4
13 HP:0003320 C1-C2 subluxation 6.303E-4 3.917E-2
2.864E-1
5.294E-1
 2 4
14 HP:0006380 Knee flexion contracture 6.528E-4 3.917E-2
2.864E-1
5.484E-1
 4 39
15 HP:0000520 Proptosis 8.321E-4 4.660E-2
3.407E-1
6.990E-1
 6 109
Show 10 more annotations

5: Mouse Phenotype [Display Chart] 2749 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0010651 aorticopulmonary septal defect 1.108E-6 1.523E-3 1.294E-2 3.045E-3 9 95
2 MP:0010650 abnormal aorticopulmonary septum morphology 1.108E-6 1.523E-3 1.294E-2 3.045E-3 9 95
3 MP:0011504 abnormal limb long bone morphology 2.595E-6 2.077E-3 1.765E-2 7.132E-3 18 452
4 MP:0010454 abnormal truncus arteriosus septation 3.022E-6 2.077E-3 1.765E-2 8.307E-3 9 107
5 MP:0002115 abnormal limb bone morphology 5.065E-6 2.197E-3 1.866E-2 1.392E-2 18 474
6 MP:0004087 abnormal muscle fiber morphology 5.128E-6 2.197E-3 1.866E-2 1.410E-2 17 427
7 MP:0000484 abnormal pulmonary artery morphology 5.652E-6 2.197E-3 1.866E-2 1.554E-2 7 62
8 MP:0003857 abnormal hindlimb zeugopod morphology 6.393E-6 2.197E-3 1.866E-2 1.757E-2 13 259
9 MP:0004508 abnormal pectoral girdle bone morphology 1.003E-5 2.574E-3 2.187E-2 2.758E-2 13 270
10 MP:0002633 persistent truncus arteriosis 1.008E-5 2.574E-3 2.187E-2 2.771E-2 8 94
11 MP:0006126 abnormal cardiac outflow tract development 1.030E-5 2.574E-3 2.187E-2 2.832E-2 10 157
12 MP:0001176 abnormal lung development 1.594E-5 3.414E-3 2.900E-2 4.382E-2 10 165
13 MP:0000558 abnormal tibia morphology 1.614E-5 3.414E-3 2.900E-2 4.438E-2 12 241
14 MP:0006382 abnormal lung epithelium morphology 3.036E-5 5.710E-3 4.852E-2
8.346E-2
 9 142
15 MP:0004573 absent limb buds 3.263E-5 5.710E-3 4.852E-2
8.969E-2
 4 17
16 MP:0003279 aneurysm 3.323E-5 5.710E-3 4.852E-2
9.136E-2
 6 55
17 MP:0003115 abnormal respiratory system development 4.907E-5 7.935E-3
6.742E-2
1.349E-1
 10 188
18 MP:0000556 abnormal hindlimb morphology 5.684E-5 8.680E-3
7.375E-2
1.562E-1
 15 413
19 MP:0000767 abnormal smooth muscle morphology 6.359E-5 9.200E-3
7.817E-2
1.748E-1
 9 156
20 MP:0003641 small lung 6.720E-5 9.237E-3
7.848E-2
1.847E-1
 8 122
21 MP:0001688 abnormal somite development 7.058E-5 9.239E-3
7.850E-2
1.940E-1
 11 237
22 MP:0001178 pulmonary hypoplasia 7.918E-5 9.687E-3
8.231E-2
2.177E-1
 6 64
23 MP:0000260 abnormal angiogenesis 8.105E-5 9.687E-3
8.231E-2
2.228E-1
 14 377
24 MP:0000550 abnormal forelimb morphology 1.057E-4 1.211E-2
1.029E-1
2.906E-1
 10 206
25 MP:0009284 abnormal sympathetic neuron innervation pattern 1.119E-4 1.230E-2
1.045E-1
3.075E-1
 3 9
26 MP:0000287 heart valve hypoplasia 1.263E-4 1.335E-2
1.135E-1
3.472E-1
 2 2
27 MP:0000759 abnormal skeletal muscle morphology 1.349E-4 1.354E-2
1.151E-1
3.708E-1
 15 446
28 MP:0004391 abnormal respiratory conducting tube morphology 1.379E-4 1.354E-2
1.151E-1
3.792E-1
 7 101
29 MP:0010395 abnormal pharyngeal arch development 1.585E-4 1.502E-2
1.276E-1
4.357E-1
 3 10
30 MP:0002932 abnormal joint morphology 1.848E-4 1.604E-2
1.363E-1
5.080E-1
 12 310
31 MP:0004881 abnormal lung size 1.902E-4 1.604E-2
1.363E-1
5.230E-1
 9 180
32 MP:0006055 abnormal vascular endothelial cell morphology 1.924E-4 1.604E-2
1.363E-1
5.288E-1
 6 75
33 MP:0000157 abnormal sternum morphology 1.955E-4 1.604E-2
1.363E-1
5.374E-1
 10 222
34 MP:0013550 abnormal secondary palate morphology 1.983E-4 1.604E-2
1.363E-1
5.452E-1
 9 181
35 MP:0008148 abnormal sternocostal joint morphology 2.070E-4 1.626E-2
1.381E-1
5.690E-1
 6 76
36 MP:0011261 abnormal limb mesenchyme morphology 2.161E-4 1.650E-2
1.402E-1
5.941E-1
 3 11
37 MP:0000538 abnormal urinary bladder morphology 2.561E-4 1.903E-2
1.616E-1
7.039E-1
 6 79
38 MP:0002267 abnormal bronchiole morphology 2.844E-4 2.015E-2
1.712E-1
7.819E-1
 5 52
39 MP:0008023 abnormal styloid process morphology 2.858E-4 2.015E-2
1.712E-1
7.857E-1
 3 12
40 MP:0001785 edema 3.005E-4 2.051E-2
1.743E-1
8.260E-1
 15 480
41 MP:0008271 abnormal bone ossification 3.059E-4 2.051E-2
1.743E-1
8.410E-1
 14 428
42 MP:0003358 abnormal hypaxial muscle morphology 3.236E-4 2.118E-2
1.800E-1
8.897E-1
 8 153
43 MP:0006113 abnormal heart septum morphology 3.318E-4 2.121E-2
1.802E-1
9.122E-1
 13 380
44 MP:0004936 impaired branching involved in ureteric bud morphogenesis 4.382E-4 2.691E-2
2.287E-1
1.000E0
 5 57
45 MP:0000454 abnormal jaw morphology 4.642E-4 2.691E-2
2.287E-1
1.000E0
 14 446
46 MP:0012176 abnormal head development 4.753E-4 2.691E-2
2.287E-1
1.000E0
 5 58
47 MP:0002754 dilated heart right ventricle 4.753E-4 2.691E-2
2.287E-1
1.000E0
 5 58
48 MP:0009886 failure of palatal shelf elevation 4.882E-4 2.691E-2
2.287E-1
1.000E0
 4 33
49 MP:0000761 thin diaphragm muscle 4.882E-4 2.691E-2
2.287E-1
1.000E0
 4 33
50 MP:0010942 abnormal respiratory epithelium morphology 4.895E-4 2.691E-2
2.287E-1
1.000E0
 10 249
Show 45 more annotations

6: Domain [Display Chart] 924 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR018361 Caveolin CS InterPro 1.383E-4 2.556E-2
1.893E-1
1.278E-1
 2 3
2 PS01210 CAVEOLIN PROSITE 1.383E-4 2.556E-2
1.893E-1
1.278E-1
 2 3
3 PF01146 Caveolin Pfam 1.383E-4 2.556E-2
1.893E-1
1.278E-1
 2 3
4 IPR001612 Caveolin InterPro 1.383E-4 2.556E-2
1.893E-1
1.278E-1
 2 3
5 IPR011398 FBN InterPro 1.383E-4 2.556E-2
1.893E-1
1.278E-1
 2 3
6 SM00406 IGv SMART 1.725E-4 2.656E-2
1.967E-1
1.594E-1
 5 76
7 IPR004061 S1P rcpt InterPro 4.570E-4 4.691E-2
3.475E-1
4.222E-1
 2 5
8 PF09289 FOLN Pfam 4.570E-4 4.691E-2
3.475E-1
4.222E-1
 2 5
9 IPR015369 Follistatin/Osteonectin EGF InterPro 4.570E-4 4.691E-2
3.475E-1
4.222E-1
 2 5
Show 4 more annotations

7: Pathway [Display Chart] 787 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 83067 Focal adhesion BioSystems: KEGG 1.048E-5 4.122E-3 2.987E-2 8.248E-3 10 206
2 161003 L1CAM interactions BioSystems: REACTOME 1.559E-5 4.122E-3 2.987E-2 1.227E-2 7 94
3 576262 Extracellular matrix organization BioSystems: REACTOME 1.571E-5 4.122E-3 2.987E-2 1.237E-2 11 264
4 105688 Axon guidance BioSystems: REACTOME 8.205E-5 1.294E-2
9.377E-2
6.457E-2
 10 262
5 160966 Cell junction organization BioSystems: REACTOME 8.222E-5 1.294E-2
9.377E-2
6.470E-2
 6 84
6 477132 Cell-Cell communication BioSystems: REACTOME 1.313E-4 1.497E-2
1.085E-1
1.034E-1
 7 131
7 782000 Proteoglycans in cancer BioSystems: KEGG 1.331E-4 1.497E-2
1.085E-1
1.048E-1
 9 225
8 198795 Focal Adhesion BioSystems: WikiPathways 1.810E-4 1.781E-2
1.291E-1
1.425E-1
 8 184
9 161006 Signal transduction by L1 BioSystems: REACTOME 2.201E-4 1.896E-2
1.374E-1
1.732E-1
 4 35
10 477129 Developmental Biology BioSystems: REACTOME 2.409E-4 1.896E-2
1.374E-1
1.896E-1
 12 419
11 M3008 Genes encoding structural ECM glycoproteins MSigDB C2 BIOCARTA (v5.1) 2.786E-4 1.993E-2
1.444E-1
2.192E-1
 8 196
12 790012 Biosynthesis of amino acids BioSystems: KEGG 4.026E-4 2.640E-2
1.913E-1
3.168E-1
 5 73
13 P00007 Axon guidance mediated by semaphorins PantherDB 5.422E-4 3.282E-2
2.379E-1
4.267E-1
 3 19
14 M5884 Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans MSigDB C2 BIOCARTA (v5.1) 5.872E-4 3.301E-2
2.392E-1
4.622E-1
 9 275
15 105908 Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) BioSystems: REACTOME 7.350E-4 3.694E-2
2.676E-1
5.784E-1
 3 21
16 137945 amb2 Integrin signaling BioSystems: Pathway Interaction Database 7.509E-4 3.694E-2
2.676E-1
5.910E-1
 4 48
17 M3468 Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix MSigDB C2 BIOCARTA (v5.1) 1.007E-3 4.661E-2
3.377E-1
7.924E-1
 8 238
Show 12 more annotations

8: Pubmed [Display Chart] 26679 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 21423176 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for Ã?-Pix in negative regulation of focal adhesion maturation. Pubmed 4.896E-13 7.113E-9 7.660E-8 1.306E-8 13 286
2 20628624:gr Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". GeneRIF 7.998E-13 7.113E-9 7.660E-8 2.134E-8 11 172
3 20628624 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". Pubmed 7.998E-13 7.113E-9 7.660E-8 2.134E-8 11 172
4 19276073:gr Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to connective tissue growth factor/CCN2 because of an increase in the levels of endogenous fibronectin. GeneRIF 1.540E-8 5.868E-5 6.320E-4 4.108E-4 3 3
5 25034023 Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly. Pubmed 1.540E-8 5.868E-5 6.320E-4 4.108E-4 3 3
6 16967187:gr Expression of discoidin domain receptor 2 (DDR2) extracellular domain in pichia pastoris and functional analysis in synovial fibroblasts and NIT3T3 cells. GeneRIF 1.540E-8 5.868E-5 6.320E-4 4.108E-4 3 3
7 16967187 Expression of discoidin domain receptor 2 (DDR2) extracellular domain in pichia pastoris and functional analysis in synovial fibroblasts and NIT3T3 cells. Pubmed 1.540E-8 5.868E-5 6.320E-4 4.108E-4 3 3
8 16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Pubmed 2.049E-8 6.834E-5 7.360E-4 5.467E-4 9 257
9 19789190:gr A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. GeneRIF 2.633E-8 7.026E-5 7.566E-4 7.026E-4 7 121
10 19789190 A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. Pubmed 2.633E-8 7.026E-5 7.566E-4 7.026E-4 7 121
11 23979707 SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Pubmed 4.559E-8 1.106E-4 1.191E-3 1.216E-3 7 131
12 21047970 The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus. Pubmed 6.148E-8 1.262E-4 1.359E-3 1.640E-3 3 4
13 7523391 Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures. Pubmed 6.148E-8 1.262E-4 1.359E-3 1.640E-3 3 4
14 19581412 Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. Pubmed 1.157E-7 2.205E-4 2.374E-3 3.087E-3 5 46
15 26601954 Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation. Pubmed 1.534E-7 2.729E-4 2.938E-3 4.093E-3 3 5
16 23744893 PAK1 regulates breast cancer cell invasion through secretion of matrix metalloproteinases in response to prolactin and three-dimensional collagen IV. Pubmed 3.063E-7 4.806E-4 5.176E-3 8.171E-3 3 6
17 17979883:gr Matrix metalloproteinase-2, caveolins, focal adhesion kinase and c-Kit in cells of the mouse myocardium. GeneRIF 3.063E-7 4.806E-4 5.176E-3 8.171E-3 3 6
18 25108383 Genome-wide association analyses identify variants in developmental genes associated with hypospadias. Pubmed 4.580E-7 6.788E-4 7.310E-3 1.222E-2 4 25
19 19453261:gr High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. GeneRIF 5.977E-7 7.974E-4 8.587E-3 1.595E-2 9 383
20 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 5.977E-7 7.974E-4 8.587E-3 1.595E-2 9 383
21 23667531 The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. Pubmed 6.344E-7 8.059E-4 8.679E-3 1.692E-2 8 282
22 16356191:gr Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study. GeneRIF 8.544E-7 8.279E-4 8.915E-3 2.279E-2 3 8
23 16356191 Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study. Pubmed 8.544E-7 8.279E-4 8.915E-3 2.279E-2 3 8
24 24503185 Interleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progression. Pubmed 1.279E-6 8.279E-4 8.915E-3 3.413E-2 3 9
25 25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. Pubmed 1.330E-6 8.279E-4 8.915E-3 3.549E-2 6 136
26 23357697 TGF-beta1 induces the different expressions of lysyl oxidases and matrix metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after mechanical injury. Pubmed 1.824E-6 8.279E-4 8.915E-3 4.866E-2 3 10
27 23357697:gr TGF-beta1 induces the different expressions of lysyl oxidases and matrix metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after mechanical injury. GeneRIF 1.824E-6 8.279E-4 8.915E-3 4.866E-2 3 10
28 20634891:gr Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. GeneRIF 2.094E-6 8.279E-4 8.915E-3
5.587E-2
 8 331
29 20634891 Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Pubmed 2.094E-6 8.279E-4 8.915E-3
5.587E-2
 8 331
30 16009940 Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. Pubmed 2.540E-6 8.279E-4 8.915E-3
6.776E-2
 6 152
31 19578796:gr Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. GeneRIF 2.540E-6 8.279E-4 8.915E-3
6.776E-2
 6 152
32 19578796 Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. Pubmed 2.540E-6 8.279E-4 8.915E-3
6.776E-2
 6 152
33 20062060 Genome-wide association study of PR interval. Pubmed 3.332E-6 8.279E-4 8.915E-3
8.889E-2
 3 12
34 14718574 The human plasma proteome: a nonredundant list developed by combination of four separate sources. Pubmed 4.223E-6 8.279E-4 8.915E-3
1.127E-1
 6 166
35 9615235 Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. Pubmed 4.323E-6 8.279E-4 8.915E-3
1.153E-1
 3 13
36 25241761 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. Pubmed 4.844E-6 8.279E-4 8.915E-3
1.292E-1
 8 371
37 26871637 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Pubmed 5.137E-6 8.279E-4 8.915E-3
1.370E-1
 8 374
38 20551380 Proteomics characterization of extracellular space components in the human aorta. Pubmed 5.987E-6 8.279E-4 8.915E-3
1.597E-1
 5 101
39 22782528:gr Selective integrin subunit reduction disrupts fibronectin extracellular matrix deposition and fibrillin 1 gene expression. GeneRIF 6.237E-6 8.279E-4 8.915E-3
1.664E-1
 2 2
40 15131124:gr MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils. GeneRIF 6.237E-6 8.279E-4 8.915E-3
1.664E-1
 2 2
41 20814177 Connective tissue growth factor cooperates with fibronectin in enhancing attachment and migration of corneal epithelial cells. Pubmed 6.237E-6 8.279E-4 8.915E-3
1.664E-1
 2 2
42 25771201 CDH2 and CDH11 act as regulators of stem cell fate decisions. Pubmed 6.237E-6 8.279E-4 8.915E-3
1.664E-1
 2 2
43 21045016 Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells. Pubmed 6.237E-6 8.279E-4 8.915E-3
1.664E-1
 2 2
44 10855793 Characterization of trinucleotide- and tandem repeat-containing transcripts obtained from human spinal cord cDNA library by high-density filter hybridization. Pubmed 6.237E-6 8.279E-4 8.915E-3
1.664E-1
 2 2
45 17119035:gr Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. GeneRIF 6.237E-6 8.279E-4 8.915E-3
1.664E-1
 2 2
46 12225805 Human fibronectin and MMP-2 collagen binding domains compete for collagen binding sites and modify cellular activation of MMP-2. Pubmed 6.237E-6 8.279E-4 8.915E-3
1.664E-1
 2 2
47 12399449 Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils. Pubmed 6.237E-6 8.279E-4 8.915E-3
1.664E-1
 2 2
48 19539600:gr Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2. GeneRIF 6.237E-6 8.279E-4 8.915E-3
1.664E-1
 2 2
49 16800003 Requirement of reversible caldesmon phosphorylation at P21-activated kinase-responsive sites for lamellipodia extensions during cell migration. Pubmed 6.237E-6 8.279E-4 8.915E-3
1.664E-1
 2 2
50 23164104 [Polymorphism of metalloproteinases MMP-1 and MMP-2 in risk of laryngeal cancer]. Pubmed 6.237E-6 8.279E-4 8.915E-3
1.664E-1
 2 2
Show 45 more annotations

9: Interaction [Display Chart] 3188 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:COL1A1 COL1A1 interactions 2.901E-7 9.249E-4 7.995E-3 9.249E-4 7 58
2 int:IGFBP3 IGFBP3 interactions 3.018E-6 4.811E-3 4.159E-2 9.622E-3 5 30
3 int:LTBP1 LTBP1 interactions 9.346E-6 9.195E-3
7.949E-2
 2.979E-2 4 18
4 int:MMP2 MMP2 interactions 1.154E-5 9.195E-3
7.949E-2
 3.678E-2 5 39
5 int:ELN ELN interactions 3.132E-5 1.997E-2
1.726E-1
9.983E-2
 4 24
6 int:PLAT PLAT interactions 1.143E-4 4.909E-2
4.244E-1
3.644E-1
 4 33
7 int:COL4A4 COL4A4 interactions 1.197E-4 4.909E-2
4.244E-1
3.815E-1
 3 13
8 int:DCN DCN interactions 1.617E-4 4.909E-2
4.244E-1
5.154E-1
 4 36
9 int:FLOT2 FLOT2 interactions 1.630E-4 4.909E-2
4.244E-1
5.196E-1
 5 67
10 int:CDH11 CDH11 interactions 1.747E-4 4.909E-2
4.244E-1
5.570E-1
 2 3
11 int:COL6A3 COL6A3 interactions 1.747E-4 4.909E-2
4.244E-1
5.570E-1
 2 3
12 int:CD44 CD44 interactions 1.874E-4 4.909E-2
4.244E-1
5.974E-1
 5 69
13 int:COL2A1 COL2A1 interactions 2.002E-4 4.909E-2
4.244E-1
6.382E-1
 4 38
Show 8 more annotations

10: Cytoband [Display Chart] 123 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3q13.1 3q13.1 1.386E-4 1.704E-2
9.192E-2
 1.704E-2 2 5

11: Transcription Factor Binding Site [Display Chart] 494 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$SOX9 B1 V$SOX9 B1 1.940E-5 7.479E-3
5.071E-2
 9.585E-3 10 192
2 V$AFP1 Q6 V$AFP1 Q6 3.557E-5 7.479E-3
5.071E-2
 1.757E-2 10 206
3 V$FREAC2 01 V$FREAC2 01 4.542E-5 7.479E-3
5.071E-2
 2.244E-2 10 212
4 V$PAX2 02 V$PAX2 02 1.988E-4 1.759E-2
1.193E-1
9.819E-2
 9 206
5 V$AR 02 V$AR 02 2.053E-4 1.759E-2
1.193E-1
1.014E-1
 4 30
6 V$POU3F2 02 V$POU3F2 02 2.137E-4 1.759E-2
1.193E-1
1.056E-1
 9 208
7 V$HP1SITEFACTOR Q6 V$HP1SITEFACTOR Q6 5.625E-4 3.401E-2
2.306E-1
2.779E-1
 8 189
8 TCCATTKW UNKNOWN TCCATTKW UNKNOWN 6.030E-4 3.401E-2
2.306E-1
2.979E-1
 8 191
9 CATTGTYY V$SOX9 B1 CATTGTYY V$SOX9 B1 6.333E-4 3.401E-2
2.306E-1
3.129E-1
 10 293
10 TGATTTRY V$GFI1 01 TGATTTRY V$GFI1 01 6.885E-4 3.401E-2
2.306E-1
3.401E-1
 9 244
11 V$SRY 02 V$SRY 02 7.895E-4 3.546E-2
2.404E-1
3.900E-1
 8 199
12 V$TEF Q6 V$TEF Q6 9.886E-4 3.895E-2
2.641E-1
4.884E-1
 8 206
13 V$AREB6 04 V$AREB6 04 1.052E-3 3.895E-2
2.641E-1
5.198E-1
 8 208
14 AAAYRNCTG UNKNOWN AAAYRNCTG UNKNOWN 1.104E-3 3.895E-2
2.641E-1
5.453E-1
 10 315
15 V$CDC5 01 V$CDC5 01 1.263E-3 4.161E-2
2.821E-1
6.241E-1
 8 214
16 V$FAC1 01 V$FAC1 01 1.424E-3 4.201E-2
2.849E-1
7.035E-1
 7 169
17 V$POU3F2 01 V$POU3F2 01 1.446E-3 4.201E-2
2.849E-1
7.142E-1
 5 84
18 V$PAX4 04 V$PAX4 04 1.576E-3 4.325E-2
2.933E-1
7.785E-1
 7 172
Show 13 more annotations

12: Gene Family [Display Chart] 76 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 206 Sphingosine 1-phosphate receptors genenames.org 2.087E-4 1.025E-2
5.037E-2
 1.586E-2 2 5
2 594 CD molecules|V-set domain containing|Immunoglobulin like domain containing genenames.org 2.697E-4 1.025E-2
5.037E-2
 2.050E-2 6 193
3 471 CD molecules|V-set domain containing|Immunoglobulin like domain containing|Carcinoembryonic antigen related cell adhesion molecule family genenames.org 4.677E-4 1.101E-2
5.409E-2
 3.554E-2 8 394
4 1278 SPARC family genenames.org 5.792E-4 1.101E-2
5.409E-2
 4.402E-2 2 8
5 321 Receptor Tyrosine Kinases|Fibronectin type III domain containing|V-set domain containing|Immunoglobulin like domain containing genenames.org 8.292E-4 1.260E-2
6.194E-2
6.302E-2
 3 40
6 529 Zinc fingers C2H2-type|ZF class homeoboxes and pseudogenes genenames.org 2.127E-3 2.694E-2
1.324E-1
1.616E-1
 2 15
7 757 SRY-boxes genenames.org 3.423E-3 3.716E-2
1.826E-1
2.601E-1
 2 19
Show 2 more annotations

13: Coexpression [Display Chart] 6243 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13867 Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.870E-36 1.168E-32 1.088E-31 1.168E-32 34 256
2 M2293 Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.981E-32 2.179E-28 2.030E-27 4.358E-28 33 315
3 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v5.1) 1.273E-27 2.649E-24 2.468E-23 7.946E-24 26 200
4 M19541 Genes commonly down-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.253E-25 1.956E-22 1.822E-21 7.822E-22 31 408
5 M17471 Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS, non-invasive). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.749E-22 2.184E-19 2.035E-18 1.092E-18 27 351
6 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.063E-21 1.106E-18 1.031E-17 6.638E-18 29 460
7 M14507 Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.434E-19 1.279E-16 1.191E-15 8.950E-16 27 454
8 M17079 Up-regulated genes distinguishing between two subtypes of gastric cancer: advanced (AGC) and early (EGC). MSigDB C2: CGP Curated Gene Sets (v5.1) 7.512E-19 5.862E-16 5.461E-15 4.690E-15 19 175
9 M12225 Up-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.529E-17 1.061E-14 9.882E-14 9.546E-14 19 205
10 M2310 Genes down-regulated by MYC [GeneID=4609], according to the MYC Target Gene Database. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.791E-16 4.864E-13 4.532E-12 4.864E-12 19 253
11 M2001 Genes associated with migration rate of 40 human bladder cancer cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.960E-16 5.085E-13 4.737E-12 5.594E-12 17 184
12 M1804 Genes up-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.022E-15 2.613E-12 2.434E-11 3.135E-11 19 280
13 M13206 Genes down-regulated in TC71 and EWS502 cells (Ewing's sarcoma) by EWSR1-FLI1 [GeneID=2130;2314] as inferred from RNAi knockdown of this fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.248E-15 3.000E-12 2.795E-11 3.900E-11 20 326
14 M4665 Genes down-regulated in glomeruli of kidneys from patients with diabetic nephropathy (type 2 diabetes mellitus). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.266E-14 5.647E-12 5.261E-11 7.906E-11 22 434
15 M7514 Genes down-regulated in NIH3T3 cells (fibroblasts) transformed by expression of contitutively active (Q63L) form of RHOA [GeneID=387] off plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.009E-14 8.363E-12 7.791E-11 1.254E-10 21 394
16 M2128 Genes up-regulated in growing IMR90 cells (fibroblast) after knockdown of RB1 [GeneID=5925] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.301E-12 4.839E-10 4.508E-9 8.122E-9 16 243
17 M2573 Genes consistently up-regulated in mammary stem cells both in mouse and human species. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.318E-12 4.839E-10 4.508E-9 8.227E-9 21 489
18 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.649E-12 1.266E-9 1.179E-8 2.278E-8 16 260
19 M3955 Integrin, VEGF, Wnt and TGFbeta signaling pathway genes up-regulated in PC-3 cells (prostate cancer) after knockdown of PDEF [GeneID=25803] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.319E-11 4.326E-9 4.030E-8 8.233E-8 10 71
20 M16975 Up-regulated genes in peripheral zone of human pancreatic cancer growing in the pancreas of nude mice compared to that of the tumor from the central zone. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.386E-11 4.326E-9 4.030E-8 8.651E-8 16 284
21 M14555 Down-regulated at any timepoint following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v5.1) 1.539E-11 4.575E-9 4.262E-8 9.607E-8 12 128
22 M2769 Genes down-regulated during early stages of differentiation of embryoid bodies from V6.5 embryonic stem cells. MSigDB C6: Oncogenic Signatures (v5.1) 3.291E-11 9.339E-9 8.700E-8 2.054E-7 13 172
23 M3015 Genes whose expression positively correlated with sensitivity of breast cancer cell lines to dasatinib [PubChem=3062316]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.495E-11 1.182E-8 1.101E-7 2.806E-7 10 80
24 M15193 Genes up-regulated in pancreatic ductal adenocarcinoma (PDAC) identified in a meta analysis across four independent studies. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.543E-11 1.182E-8 1.101E-7 2.836E-7 17 358
25 M2871 YAP conserved signature. MSigDB C6: Oncogenic Signatures (v5.1) 4.956E-11 1.238E-8 1.153E-7 3.094E-7 9 57
26 M2030 Genes down-regulated in mesenchymal stem cells during late phase of adipogenesis, defined as days 7 to 14 of culturing with adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.284E-11 1.269E-8 1.182E-7 3.299E-7 8 38
27 M863 Myb-regulated genes in MCF7 (breast cancer) and lung epithelial cell lines overexpressing MYBL2, MYBL1 or MYB [GeneID=4605;4603;4602]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.491E-11 1.732E-8 1.614E-7 4.677E-7 16 318
28 M14098 Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 24 h time point that were not down-regulated at the previous time point, 20 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.559E-11 1.908E-8 1.778E-7 5.344E-7 12 148
29 M15491 Genes down-regulated in MDA-MB-231 cells (breast cancer) after knockdown of SATB1 [GeneID=6304] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.442E-10 3.049E-8 2.840E-7 9.004E-7 18 442
30 M2572 Genes in the 'mesenchymal transition signature' common to all invasive cancer types. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.465E-10 3.049E-8 2.840E-7 9.146E-7 9 64
31 M4995 Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.717E-10 3.457E-8 3.221E-7 1.072E-6 17 390
32 M259 Genes up-regulated in response to both hypoxia and overexpression of an active form of HIF1A [GeneID=3091]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.326E-10 6.489E-8 6.046E-7 2.077E-6 13 207
33 M7363 Genes up-regulated in MCF7 cells (breast cancer) under hypoxia conditions. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.599E-10 8.700E-8 8.105E-7 2.871E-6 12 171
34 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.409E-10 1.150E-7 1.072E-6 4.001E-6 17 425
35 M1616 Down-regulated at 48-96 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.450E-10 1.150E-7 1.072E-6 4.027E-6 8 51
36 M12602 Genes positively correlated with recurrence free survival in patients with hepatitis B-related (HBV) hepatocellular carcinoma (HCC). MSigDB C2: CGP Curated Gene Sets (v5.1) 6.950E-10 1.205E-7 1.123E-6 4.339E-6 10 105
37 M2256 Genes commonly down-regulated in UET-13 cells (mesenchymal progenitor) by expression of EWSR1 [GeneID=2130] fusions with ETS transcription factors FLI1 and ERG [GeneID=2313 ,2078]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.033E-9 1.744E-7 1.624E-6 6.451E-6 13 227
38 M3645 Genes up-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.203E-9 1.976E-7 1.841E-6 7.508E-6 17 443
39 M15484 Genes changed in HMLE cells (mmortalized nontransformed mammary epithelium) after RNAi knockdown of both CDH1 and CTNNB1 [GeneID=999;1499], compared to the knockdown of CDH1 alone. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.590E-9 2.474E-7 2.305E-6 9.928E-6 9 83
40 M11788 Selected genes down-regulated during invasion of lymphatic vessels during metastasis. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.613E-9 2.474E-7 2.305E-6 1.007E-5 7 36
41 M3447 Genes whose expression peaked at 60 min after stimulation of MCF10A cells with serum. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.625E-9 2.474E-7 2.305E-6 1.014E-5 8 57
42 M2196 Genes significantly de-regulated (p < 0.05) by MIR21 [GeneID=406991] in A172 cells (glioma). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.011E-9 2.989E-7 2.784E-6 1.255E-5 14 289
43 M2025 Genes down-regulated in mesenchymal stem cells during early phase of adipogenesis, defined as days 1 to 5 of culturing with adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.414E-9 3.452E-7 3.216E-6 1.507E-5 7 38
44 M5929 Genes up-regulated in ANBL-6 cell line (multiple myeloma, MM) co-cultured with bone marrow stromal cells compared to those grown in the presence of IL6 [GeneID=3569]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.478E-9 3.452E-7 3.216E-6 1.547E-5 8 60
45 M2446 Genes down-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 10 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.488E-9 3.452E-7 3.216E-6 1.553E-5 13 244
46 M2309 Genes up-regulated in RWPE-1 cells (prostate cancer) upon expression of constitutively active form of STAT3 [GeneID=6774]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.814E-9 3.819E-7 3.558E-6 1.757E-5 10 121
47 M1459 Genes up-regulated in BEC (blood endothelial cells) compared to LEC (lymphatic endothelial cells). MSigDB C2: CGP Curated Gene Sets (v5.1) 3.568E-9 4.739E-7 4.415E-6 2.227E-5 11 162
48 M4065 Down-regulated at 24 h following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v5.1) 3.644E-9 4.739E-7 4.415E-6 2.275E-5 9 91
49 M19391 Genes down-regulated in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.012E-9 5.087E-7 4.740E-6 2.504E-5 17 480
50 M2081 Genes down-regulated by TGFB1 [GeneID=7040] in MEF cells (embryonic fibroblast) via TGFB1R [GeneID=7046]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.078E-9 5.087E-7 4.740E-6 2.546E-5 12 207
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 3090 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 1.846E-31 5.704E-28 4.913E-27 5.704E-28 37 445
2 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 2.264E-27 2.699E-24 2.325E-23 6.995E-24 34 453
3 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 2.621E-27 2.699E-24 2.325E-23 8.097E-24 34 455
4 JC fibro 1000 K1 JC fibro top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 5.021E-27 3.878E-24 3.341E-23 1.551E-23 34 464
5 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 3.618E-24 2.236E-21 1.926E-20 1.118E-20 31 438
6 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 2.470E-23 1.272E-20 1.096E-19 7.633E-20 31 467
7 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 2.222E-20 9.809E-18 8.449E-17 6.866E-17 29 493
8 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 7.352E-18 2.840E-15 2.446E-14 2.272E-14 26 461
9 ratio EB vs SC 1000 K1 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 1.039E-17 3.566E-15 3.072E-14 3.210E-14 23 336
10 gudmap dev gonad e11.5 M GonadVasMes Flk 500 dev gonad e11.5 M GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.107E-16 3.420E-14 2.946E-13 3.420E-13 24 419
11 gudmap kidney adult Mesangium Meis 500 kidney adult Mesangium Meis top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.885E-16 5.296E-14 4.562E-13 5.826E-13 24 429
12 gudmap dev gonad e11.5 F GonadVasMes Flk k3 1000 dev gonad e11.5 F GonadVasMes Flk k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 4.603E-16 1.185E-13 1.021E-12 1.422E-12 22 355
13 endothelial SubClass DCN-hi Top 500 All endothelial SubClass DCN-hi Top 500 All Brain Map - Barres 4.609E-15 1.064E-12 9.162E-12 1.424E-11 24 495
14 26Dn Top 500 All 26Dn Top 500 All Brain Map - Allen iN 4.820E-15 1.064E-12 9.162E-12 1.489E-11 24 496
15 26Dn SubClass 26Dn 2 Top 500 All 26Dn SubClass 26Dn 2 Top 500 All Brain Map - Allen iN 5.268E-15 1.085E-12 9.347E-12 1.628E-11 24 498
16 gudmap kidney P0 JuxtaGlom Ren1 500 kidney P0 JuxtaGlom Ren1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.893E-15 1.524E-12 1.313E-11 2.439E-11 23 456
17 gudmap dev gonad e12.5 M InterstitLeydig MafB 500 dev gonad e12.5 M InterstitLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 9.411E-15 1.711E-12 1.473E-11 2.908E-11 21 364
18 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.714E-14 1.668E-11 1.436E-10 3.002E-10 21 410
19 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma k4 1000 dev gonad e13.5 F VascAssocMesenchStromOvary Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.451E-13 2.360E-11 2.033E-10 4.484E-10 15 168
20 gudmap dev gonad e12.5 M InterstitTestis Sma 500 dev gonad e12.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.785E-13 2.743E-11 2.363E-10 5.516E-10 20 374
21 gudmap dev gonad e11.5 F GonadVasMes Flk 500 dev gonad e11.5 F GonadVasMes Flk top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.864E-13 2.743E-11 2.363E-10 5.761E-10 21 424
22 gudmap dev gonad e11.5 M GonadVasMes Flk k4 500 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.204E-13 3.095E-11 2.666E-10 6.809E-10 16 208
23 gudmap dev gonad e11.5 M GonadVasMes Flk k1 1000 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.119E-13 4.190E-11 3.609E-10 9.638E-10 19 338
24 ratio EB vs SC 500 K5 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 500 k-means-cluster#5 PCBC 3.464E-13 4.460E-11 3.841E-10 1.070E-9 13 116
25 GSM777059 500 Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 3.650E-13 4.511E-11 3.886E-10 1.128E-9 21 439
26 PCBC ctl CardiacMyocyte 500 Progenitor-Cell-Biology-Consortium reference CardiacMyocyte top-relative-expression-ranked 500 PCBC 4.143E-13 4.923E-11 4.241E-10 1.280E-9 22 495
27 GSM777046 100 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 8.746E-13 1.001E-10 8.621E-10 2.702E-9 12 97
28 gudmap dev gonad e12.5 F VasAssocMesStromOvary Sma k4 1000 dev gonad e12.5 F VasAssocMesStromOvary Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 9.198E-13 1.015E-10 8.743E-10 2.842E-9 13 125
29 GSM605820 500 Myeloid Cells, DC.103+11b-.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3 Immgen.org, GSE15907 2.967E-12 3.161E-10 2.723E-9 9.167E-9 19 384
30 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 3.483E-12 3.471E-10 2.990E-9 1.076E-8 21 494
31 PCBC ctl BronchSmoothMuscl 500 Progenitor-Cell-Biology-Consortium reference BronchSmoothMuscl top-relative-expression-ranked 500 PCBC 3.483E-12 3.471E-10 2.990E-9 1.076E-8 21 494
32 GSM777063 500 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 5.363E-12 5.178E-10 4.460E-9 1.657E-8 20 450
33 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB k2 1000 dev gonad e13.5 F VascAssocMesenchStromOvary MafB k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 9.536E-12 8.929E-10 7.691E-9 2.947E-8 16 266
34 Lungmap Mouse e16.5 Matrix fibroblast Top 500 All Mouse Lung E16.5 Matrix Fibroblast top 500 Lungmap Mouse Single Cell (Lungmap.net) 1.409E-11 1.244E-9 1.072E-8 4.355E-8 19 420
35 Lungmap Mouse e16.5 Myofibro Top 500 All Lungmap Mouse e16.5 Myofibro Top 500 All Lungmap Mouse Single Cell (Lungmap.net) 1.409E-11 1.244E-9 1.072E-8 4.355E-8 19 420
36 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB k3 500 dev gonad e13.5 F VascAssocMesenchStromOvary MafB k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.541E-11 1.323E-9 1.139E-8 4.761E-8 12 123
37 PCBC ratio DE blastocyst vs DE cord blood cfr-2X-p05 DE blastocyst vs DE cord blood-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.905E-11 1.591E-9 1.370E-8 5.886E-8 11 96
38 gudmap dev gonad e12.5 F VasAssMesen MafB 500 dev gonad e12.5 F VasAssMesen MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.507E-11 2.852E-9 2.457E-8 1.084E-7 18 389
39 gudmap kidney adult Mesangium Meis k2 1000 kidney adult Mesangium Meis k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.525E-11 4.377E-9 3.770E-8 1.707E-7 17 348
40 facebase RNAseq e14.5 palate poster distal ERK2 WT 2500 K4 facebase RNAseq e14.5 palate poster distal ERK2 WT 2500 K4 Gudmap RNAseq 7.102E-11 5.486E-9 4.726E-8 2.195E-7 14 215
41 gudmap dev gonad e13.5 M InterstitFLeydig MafB 500 dev gonad e13.5 M InterstitFLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 7.873E-11 5.856E-9 5.044E-8 2.433E-7 17 356
42 GSM605823 500 Myeloid Cells, DC.103-11b+.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3 Immgen.org, GSE15907 7.960E-11 5.856E-9 5.044E-8 2.460E-7 18 409
43 54Dn SubClass 54Dn 1SK Top 500 Cluster 2 54Dn SubClass 54Dn 1SK Top 500 Cluster 2 Brain Map - Allen iN 1.039E-10 7.470E-9 6.434E-8 3.212E-7 15 265
44 gudmap dev gonad e12.5 F VasAssMesen MafB k4 500 dev gonad e12.5 F VasAssMesen MafB k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.267E-10 8.896E-9 7.663E-8 3.914E-7 12 147
45 PCBC ratio MESO-5 amniotic fluid MSC vs MESO-5 blastocyst cfr-2X-p05 MESO-5 amniotic fluid MSC vs MESO-5 blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.429E-10 9.597E-9 8.266E-8 4.415E-7 18 424
46 GSM538231 500 Myeloid Cells, DC.103+11b-.Lu, CD11chi CD11b low CD103+ MHCII+ SiglecF-, Lung, avg-3 Immgen.org, GSE15907 1.429E-10 9.597E-9 8.266E-8 4.415E-7 18 424
47 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.557E-10 1.013E-8 8.729E-8 4.811E-7 17 372
48 GSM777050 100 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 1.574E-10 1.013E-8 8.729E-8 4.865E-7 10 87
49 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 2.401E-10 1.514E-8 1.304E-7 7.420E-7 19 496
50 GSM605862 500 Myeloid Cells, MF.Thio5.II-480hi.PC, CD115+ MHC II- F480hi Siglec F-, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 2.695E-10 1.665E-8 1.434E-7 8.327E-7 18 441
Show 45 more annotations

15: Computational [Display Chart] 283 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 4.943E-14 1.399E-11 8.707E-11 1.399E-11 20 216
2 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 1.456E-12 1.822E-10 1.134E-9 4.120E-10 23 361
3 GNF2 PTX3 Neighborhood of PTX3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.931E-12 1.822E-10 1.134E-9 5.465E-10 10 36
4 module 3 Genes in module 3 MSigDb: C4 - CM: Cancer Modules 3.212E-12 2.273E-10 1.415E-9 9.091E-10 23 375
5 GNF2 MMP1 Neighborhood of MMP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.306E-11 1.305E-9 8.126E-9 6.527E-9 9 32
6 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 3.126E-11 1.475E-9 9.178E-9 8.847E-9 23 419
7 GNF2 CDH11 Neighborhood of CDH11 MSigDb: C4 - CGN: Cancer Gene Neighborhood 9.772E-11 3.951E-9 2.459E-8 2.765E-8 8 25
8 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 4.722E-10 1.671E-8 1.040E-7 1.336E-7 21 395
9 module 122 Genes in module 122 MSigDb: C4 - CM: Cancer Modules 1.545E-9 4.859E-8 3.025E-7 4.374E-7 13 138
10 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 3.035E-7 8.589E-6 5.346E-5 8.589E-5 17 378
11 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 5.911E-7 1.521E-5 9.465E-5 1.673E-4 16 351
12 module 220 Genes in module 220 MSigDb: C4 - CM: Cancer Modules 1.331E-6 3.139E-5 1.954E-4 3.766E-4 15 328
13 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 6.753E-6 1.470E-4 9.150E-4 1.911E-3 16 423
14 module 324 Genes in module 324 MSigDb: C4 - CM: Cancer Modules 6.318E-5 1.277E-3 7.950E-3 1.788E-2 8 131
15 module 18 Genes in module 18 MSigDb: C4 - CM: Cancer Modules 1.586E-4 2.992E-3 1.862E-2 4.488E-2 14 436
16 module 128 Genes in module 128 MSigDb: C4 - CM: Cancer Modules 5.354E-4 9.375E-3
5.835E-2
1.515E-1
 6 98
17 module 79 Genes in module 79 MSigDb: C4 - CM: Cancer Modules 5.963E-4 9.375E-3
5.835E-2
1.687E-1
 6 100
18 module 170 Genes in module 170 MSigDb: C4 - CM: Cancer Modules 5.963E-4 9.375E-3
5.835E-2
1.687E-1
 6 100
19 module 38 Genes in module 38 MSigDb: C4 - CM: Cancer Modules 8.413E-4 1.253E-2
7.800E-2
2.381E-1
 13 455
20 module 105 Genes in module 105 MSigDb: C4 - CM: Cancer Modules 9.182E-4 1.299E-2
8.087E-2
2.598E-1
 8 194
21 module 8 Genes in module 8 MSigDb: C4 - CM: Cancer Modules 1.006E-3 1.356E-2
8.440E-2
2.848E-1
 12 406
22 module 259 Genes in module 259 MSigDb: C4 - CM: Cancer Modules 1.297E-3 1.668E-2
1.038E-1
3.669E-1
 4 46
23 module 85 Genes in module 85 MSigDb: C4 - CM: Cancer Modules 1.908E-3 2.348E-2
1.462E-1
5.401E-1
 4 51
24 module 199 Genes in module 199 MSigDb: C4 - CM: Cancer Modules 2.876E-3 3.166E-2
1.971E-1
8.140E-1
 4 57
25 module 513 Genes in module 513 MSigDb: C4 - CM: Cancer Modules 2.892E-3 3.166E-2
1.971E-1
8.186E-1
 2 8
26 module 385 Genes in module 385 MSigDb: C4 - CM: Cancer Modules 2.981E-3 3.166E-2
1.971E-1
8.435E-1
 3 28
27 module 119 Genes in module 119 MSigDb: C4 - CM: Cancer Modules 3.020E-3 3.166E-2
1.971E-1
8.548E-1
 6 137
28 module 6 Genes in module 6 MSigDb: C4 - CM: Cancer Modules 3.310E-3 3.346E-2
2.082E-1
9.368E-1
 11 407
29 module 524 Genes in module 524 MSigDb: C4 - CM: Cancer Modules 3.639E-3 3.551E-2
2.210E-1
1.000E0
 3 30
30 module 291 Genes in module 291 MSigDb: C4 - CM: Cancer Modules 4.136E-3 3.902E-2
2.429E-1
1.000E0
 4 63
31 module 540 Genes in module 540 MSigDb: C4 - CM: Cancer Modules 4.586E-3 4.186E-2
2.606E-1
1.000E0
 2 10
32 module 419 Genes in module 419 MSigDb: C4 - CM: Cancer Modules 5.204E-3 4.602E-2
2.865E-1
1.000E0
 3 34
33 module 211 Genes in module 211 MSigDb: C4 - CM: Cancer Modules 5.567E-3 4.774E-2
2.972E-1
1.000E0
 2 11
34 module 44 Genes in module 44 MSigDb: C4 - CM: Cancer Modules 5.934E-3 4.939E-2
3.075E-1
1.000E0
 9 319
Show 29 more annotations

16: MicroRNA [Display Chart] 1339 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-890:PITA hsa-miR-890:PITA TOP PITA 6.530E-10 7.134E-7 5.548E-6 8.744E-7 14 241
2 hsa-miR-145:PITA hsa-miR-145:PITA TOP PITA 1.130E-9 7.134E-7 5.548E-6 1.514E-6 17 401
3 hsa-miR-767-3p:PITA hsa-miR-767-3p:PITA TOP PITA 1.598E-9 7.134E-7 5.548E-6 2.140E-6 13 214
4 hsa-miR-432:PITA hsa-miR-432:PITA TOP PITA 8.437E-9 2.824E-6 2.197E-5 1.130E-5 11 160
5 hsa-miR-1305:PITA hsa-miR-1305:PITA TOP PITA 4.683E-8 1.254E-5 9.754E-5 6.271E-5 16 453
6 hsa-miR-885-5p:PITA hsa-miR-885-5p:PITA TOP PITA 1.359E-7 2.284E-5 1.776E-4 1.819E-4 10 165
7 hsa-miR-641:PITA hsa-miR-641:PITA TOP PITA 1.370E-7 2.284E-5 1.776E-4 1.835E-4 16 490
8 hsa-miR-211:PITA hsa-miR-211:PITA TOP PITA 1.535E-7 2.284E-5 1.776E-4 2.056E-4 15 431
9 hsa-miR-204:PITA hsa-miR-204:PITA TOP PITA 1.535E-7 2.284E-5 1.776E-4 2.056E-4 15 431
10 hsa-miR-768-5p:PITA hsa-miR-768-5p:PITA TOP PITA 1.898E-7 2.541E-5 1.977E-4 2.541E-4 9 130
11 hsa-miR-647:PITA hsa-miR-647:PITA TOP PITA 2.353E-7 2.865E-5 2.228E-4 3.151E-4 10 175
12 hsa-miR-33a:PITA hsa-miR-33a:PITA TOP PITA 3.462E-7 3.723E-5 2.896E-4 4.635E-4 11 230
13 hsa-miR-33b:PITA hsa-miR-33b:PITA TOP PITA 3.615E-7 3.723E-5 2.896E-4 4.840E-4 11 231
14 hsa-miR-224:TargetScan hsa-miR-224:TargetScan TargetScan 4.473E-7 4.279E-5 3.328E-4 5.990E-4 11 236
15 CTCCAAG,MIR-432:MSigDB CTCCAAG,MIR-432:MSigDB MSigDB 6.610E-7 5.901E-5 4.589E-4 8.851E-4 7 76
16 hsa-miR-363:PITA hsa-miR-363:PITA TOP PITA 7.068E-7 5.915E-5 4.600E-4 9.464E-4 15 486
17 hsa-miR-410:PITA hsa-miR-410:PITA TOP PITA 8.139E-7 6.410E-5 4.986E-4 1.090E-3 13 364
18 hsa-miR-1259:PITA hsa-miR-1259:PITA TOP PITA 1.018E-6 7.572E-5 5.889E-4 1.363E-3 12 312
19 hsa-miR-582-3p:PITA hsa-miR-582-3p:PITA TOP PITA 1.078E-6 7.596E-5 5.908E-4 1.443E-3 11 258
20 ACTGTGA,MIR-27B:MSigDB ACTGTGA,MIR-27B:MSigDB MSigDB 1.432E-6 9.129E-5 7.100E-4 1.917E-3 14 447
21 ACTGTGA,MIR-27A:MSigDB ACTGTGA,MIR-27A:MSigDB MSigDB 1.432E-6 9.129E-5 7.100E-4 1.917E-3 14 447
22 hsa-miR-603:PITA hsa-miR-603:PITA TOP PITA 1.521E-6 9.256E-5 7.198E-4 2.036E-3 13 385
23 hsa-miR-374a:TargetScan hsa-miR-374a:TargetScan TargetScan 1.903E-6 1.024E-4 7.964E-4 2.548E-3 14 458
24 hsa-miR-374b:TargetScan hsa-miR-374b:TargetScan TargetScan 1.903E-6 1.024E-4 7.964E-4 2.548E-3 14 458
25 hsa-miR-1272:PITA hsa-miR-1272:PITA TOP PITA 1.912E-6 1.024E-4 7.964E-4 2.560E-3 10 220
26 hsa-miR-767-5p:PITA hsa-miR-767-5p:PITA TOP PITA 2.308E-6 1.160E-4 9.023E-4 3.090E-3 11 279
27 AACTGGA,MIR-145:MSigDB AACTGGA,MIR-145:MSigDB MSigDB 2.340E-6 1.160E-4 9.023E-4 3.133E-3 10 225
28 TGGTGCT,MIR-29A:MSigDB TGGTGCT,MIR-29A:MSigDB MSigDB 3.281E-6 1.417E-4 1.102E-3 4.394E-3 14 480
29 TGGTGCT,MIR-29C:MSigDB TGGTGCT,MIR-29C:MSigDB MSigDB 3.281E-6 1.417E-4 1.102E-3 4.394E-3 14 480
30 hsa-miR-32:PITA hsa-miR-32:PITA TOP PITA 3.281E-6 1.417E-4 1.102E-3 4.394E-3 14 480
31 TGGTGCT,MIR-29B:MSigDB TGGTGCT,MIR-29B:MSigDB MSigDB 3.281E-6 1.417E-4 1.102E-3 4.394E-3 14 480
32 ATGTACA,MIR-493:MSigDB ATGTACA,MIR-493:MSigDB MSigDB 3.819E-6 1.442E-4 1.122E-3 5.113E-3 11 294
33 hsa-miR-25:PITA hsa-miR-25:PITA TOP PITA 3.877E-6 1.442E-4 1.122E-3 5.191E-3 14 487
34 hsa-miR-92a:PITA hsa-miR-92a:PITA TOP PITA 3.877E-6 1.442E-4 1.122E-3 5.191E-3 14 487
35 hsa-miR-367:PITA hsa-miR-367:PITA TOP PITA 3.877E-6 1.442E-4 1.122E-3 5.191E-3 14 487
36 hsa-miR-92b:PITA hsa-miR-92b:PITA TOP PITA 3.877E-6 1.442E-4 1.122E-3 5.191E-3 14 487
37 hsa-miR-188-5p:PITA hsa-miR-188-5p:PITA TOP PITA 5.167E-6 1.870E-4 1.454E-3 6.919E-3 9 193
38 hsa-miR-105:PITA hsa-miR-105:PITA TOP PITA 5.498E-6 1.920E-4 1.493E-3 7.362E-3 13 433
39 hsa-miR-653:PITA hsa-miR-653:PITA TOP PITA 5.592E-6 1.920E-4 1.493E-3 7.487E-3 11 306
40 hsa-miR-140-5p:TargetScan hsa-miR-140-5p:TargetScan TargetScan 6.181E-6 2.069E-4 1.609E-3 8.277E-3 10 251
41 hsa-miR-629:PITA hsa-miR-629:PITA TOP PITA 7.628E-6 2.491E-4 1.937E-3 1.021E-2 8 153
42 hsa-miR-1324:PITA hsa-miR-1324:PITA TOP PITA 1.076E-5 3.431E-4 2.668E-3 1.441E-2 11 328
43 hsa-miR-34c-5p:TargetScan hsa-miR-34c-5p:TargetScan TargetScan 1.291E-5 3.757E-4 2.922E-3 1.728E-2 13 469
44 hsa-miR-449b:TargetScan hsa-miR-449b:TargetScan TargetScan 1.291E-5 3.757E-4 2.922E-3 1.728E-2 13 469
45 hsa-miR-34a:TargetScan hsa-miR-34a:TargetScan TargetScan 1.291E-5 3.757E-4 2.922E-3 1.728E-2 13 469
46 hsa-miR-449a:TargetScan hsa-miR-449a:TargetScan TargetScan 1.291E-5 3.757E-4 2.922E-3 1.728E-2 13 469
47 hsa-miR-1253:PITA hsa-miR-1253:PITA TOP PITA 1.415E-5 3.892E-4 3.027E-3 1.895E-2 10 276
48 hsa-miR-132:PITA hsa-miR-132:PITA TOP PITA 1.424E-5 3.892E-4 3.027E-3 1.907E-2 11 338
49 hsa-miR-212:PITA hsa-miR-212:PITA TOP PITA 1.424E-5 3.892E-4 3.027E-3 1.907E-2 11 338
50 hsa-miR-224:PITA hsa-miR-224:PITA TOP PITA 1.769E-5 4.738E-4 3.685E-3 2.369E-2 11 346
Show 45 more annotations

17: Drug [Display Chart] 19689 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C010176 halofuginone CTD 5.912E-13 1.164E-8 1.218E-7 1.164E-8 13 127
2 D002762 Cholecalciferol CTD 6.234E-11 6.137E-7 6.423E-6 1.227E-6 14 224
3 D014800 Vitallium CTD 1.936E-10 1.271E-6 1.330E-5 3.812E-6 14 244
4 C001277 geldanamycin CTD 5.070E-10 2.496E-6 2.612E-5 9.983E-6 16 366
5 MESH:D011471/D001564-M Prostatic Neoplasms affected by Benzo(a)pyrene CTD Marker 1.521E-9 5.989E-6 6.268E-5 2.995E-5 11 151
6 C013186 2,3-pentanedione CTD 3.785E-9 1.242E-5 1.300E-4 7.452E-5 10 126
7 1793 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 5.001E-9 1.407E-5 1.472E-4 9.846E-5 11 169
8 D017258 Medroxyprogesterone Acetate CTD 1.028E-8 2.530E-5 2.648E-4 2.024E-4 15 390
9 D008942 Mitoxantrone CTD 2.618E-8 5.728E-5 5.994E-4 5.155E-4 12 247
10 CID000013811 isodesmosine Stitch 3.588E-8 7.065E-5 7.393E-4 7.065E-4 6 33
11 D010656 Phenylephrine CTD 4.224E-8 7.220E-5 7.555E-4 8.316E-4 16 500
12 C533894 LG 100815 CTD 5.002E-8 7.220E-5 7.555E-4 9.848E-4 8 88
13 D008769 Methylnitronitrosoguanidine CTD 5.223E-8 7.220E-5 7.555E-4 1.028E-3 12 263
14 C062198 octa-2,4,6-trienoic acid CTD 5.469E-8 7.220E-5 7.555E-4 1.077E-3 8 89
15 D007501 Iron CTD 5.603E-8 7.220E-5 7.555E-4 1.103E-3 14 380
16 CID000005711 Y-27632 Stitch 5.867E-8 7.220E-5 7.555E-4 1.155E-3 15 445
17 2691 UP 15d-PGJ2; Up 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP 6.339E-8 7.255E-5 7.593E-4 1.248E-3 10 169
18 D018021 Lithium Chloride CTD 6.633E-8 7.255E-5 7.593E-4 1.306E-3 13 325
19 CID000122155 Hlnl Stitch 7.098E-8 7.355E-5 7.697E-4 1.398E-3 5 19
20 1122 UP cytochalasin B; Up 200; 20.8uM; MCF7; HT HG-U133A EA Broad Institute CMAP 7.903E-8 7.781E-5 8.142E-4 1.556E-3 10 173
21 D016686 Monocrotaline CTD 9.139E-8 8.568E-5 8.966E-4 1.799E-3 8 95
22 3462 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 9.798E-8 8.769E-5 9.177E-4 1.929E-3 10 177
23 6755 DN Mitoxantrone dihydrochloride [70476-82-3]; Down 200; 7.8uM; PC3; HT HG-U133A Broad Institute CMAP 1.409E-7 1.206E-4 1.262E-3 2.774E-3 10 184
24 CID006540261 EI-N Stitch 1.555E-7 1.227E-4 1.285E-3 3.062E-3 11 236
25 MESH:D011471/D004958-M Prostatic Neoplasms affected by Estradiol CTD Marker 1.559E-7 1.227E-4 1.285E-3 3.069E-3 10 186
26 C113580 U 0126 CTD 2.024E-7 1.527E-4 1.599E-3 3.985E-3 14 422
27 7248 UP Triprolidine hydrochloride [550-70-9]; Up 200; 12.8uM; PC3; HT HG-U133A Broad Institute CMAP 2.095E-7 1.527E-4 1.599E-3 4.124E-3 10 192
28 6331 DN Fenoterol hydrobromide [1944-12-3]; Down 200; 10.4uM; PC3; HT HG-U133A Broad Institute CMAP 2.198E-7 1.533E-4 1.605E-3 4.328E-3 10 193
29 7125 DN Leucomisine [17946-87-1]; Down 200; 16.2uM; PC3; HT HG-U133A Broad Institute CMAP 2.306E-7 1.533E-4 1.605E-3 4.541E-3 10 194
30 MESH:D012468/D011374-T Salivary Gland Neoplasms affected by Progesterone CTD Therapeutic 2.336E-7 1.533E-4 1.605E-3 4.600E-3 4 10
31 3175 DN Cinnarizine [298-57-7]; Down 200; 10.8uM; MCF7; HT HG-U133A Broad Institute CMAP 2.786E-7 1.770E-4 1.852E-3 5.486E-3 10 198
32 C089032 rimonabant CTD 4.096E-7 2.520E-4 2.638E-3 8.065E-3 11 260
33 MESH:D015179/C014347-T Colorectal Neoplasms affected by decitabine CTD Therapeutic 4.744E-7 2.690E-4 2.816E-3 9.340E-3 6 50
34 CID000004553 NS-398 Stitch 4.766E-7 2.690E-4 2.816E-3 9.384E-3 11 264
35 5439 UP Pyrvinium pamoate [3546-41-6]; Up 200; 3.4uM; MCF7; HT HG-U133A Broad Institute CMAP 4.796E-7 2.690E-4 2.816E-3 9.443E-3 9 161
36 CID005288571 AC1NRBPT Stitch 5.053E-7 2.690E-4 2.816E-3 9.949E-3 9 162
37 D014302 Trinitrobenzenesulfonic Acid CTD 5.056E-7 2.690E-4 2.816E-3 9.955E-3 13 388
38 C483909 torcetrapib CTD 5.639E-7 2.922E-4 3.058E-3 1.110E-2 12 328
39 2439 UP Menadione [58-27-5]; Up 200; 23.2uM; HL60; HT HG-U133A Broad Institute CMAP 5.898E-7 2.977E-4 3.116E-3 1.161E-2 9 165
40 C583074 4,4'-hexafluorisopropylidene diphenol CTD 6.748E-7 3.167E-4 3.314E-3 1.329E-2 8 123
41 CID000095509 octa-2,4,6-trienoic acid Stitch 6.755E-7 3.167E-4 3.314E-3 1.330E-2 6 53
42 CID000025435 desmosine Stitch 6.755E-7 3.167E-4 3.314E-3 1.330E-2 6 53
43 C014464 3,4-dichloroaniline CTD 7.959E-7 3.644E-4 3.814E-3 1.567E-2 9 171
44 7105 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 8.773E-7 3.926E-4 4.108E-3 1.727E-2 9 173
45 D003609 Dactinomycin CTD 9.129E-7 3.994E-4 4.180E-3 1.797E-2 11 282
46 6820 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.013E-6 4.242E-4 4.440E-3 1.994E-2 9 176
47 6896 UP scriptaid; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 1.013E-6 4.242E-4 4.440E-3 1.994E-2 9 176
48 7555 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 1.062E-6 4.355E-4 4.558E-3 2.090E-2 9 177
49 2850 UP Nifuroxazide [965-52-6]; Up 200; 14.6uM; MCF7; HT HG-U133A Broad Institute CMAP 1.113E-6 4.471E-4 4.679E-3 2.191E-2 9 178
50 2675 UP prochlorperazine dimaleate salt; Up 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP 1.279E-6 5.036E-4 5.270E-3 2.518E-2 9 181
Show 45 more annotations

18: Disease [Display Chart] 2290 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0034069 Pulmonary Fibrosis DisGeNET Curated 2.369E-9 3.551E-6 2.952E-5 5.425E-6 16 317
2 umls:C1800706 Idiopathic Pulmonary Fibrosis DisGeNET Curated 3.101E-9 3.551E-6 2.952E-5 7.102E-6 16 323
3 umls:C0011644 Scleroderma DisGeNET BeFree 5.006E-9 3.821E-6 3.177E-5 1.146E-5 12 166
4 umls:C0879615 Stromal Neoplasm DisGeNET BeFree 1.101E-7 4.445E-5 3.695E-4 2.521E-4 8 76
5 umls:C0220641 Lip and Oral Cavity Carcinoma DisGeNET BeFree 1.185E-7 4.445E-5 3.695E-4 2.713E-4 16 419
6 umls:C0011884 Diabetic Retinopathy DisGeNET Curated 1.342E-7 4.445E-5 3.695E-4 3.073E-4 11 181
7 umls:C0853879 Invasive breast carcinoma DisGeNET BeFree 1.359E-7 4.445E-5 3.695E-4 3.111E-4 15 369
8 umls:C0007124 Noninfiltrating Intraductal Carcinoma DisGeNET Curated 2.263E-7 6.477E-5 5.385E-4 5.182E-4 13 281
9 umls:C0033999 Pterygium DisGeNET Curated 3.884E-7 9.881E-5 8.215E-4 8.893E-4 7 61
10 umls:C0162810 Cicatrix, Hypertrophic DisGeNET BeFree 4.863E-7 1.114E-4 9.259E-4 1.114E-3 7 63
11 umls:C0154830 Proliferative diabetic retinopathy DisGeNET BeFree 6.718E-7 1.399E-4 1.163E-3 1.538E-3 7 66
12 umls:C0206692 Carcinoma, Lobular DisGeNET Curated 8.358E-7 1.595E-4 1.326E-3 1.914E-3 6 43
13 umls:C0036095 Salivary Gland Neoplasms DisGeNET Curated 1.008E-6 1.776E-4 1.477E-3 2.309E-3 7 70
14 umls:C0010606 Adenoid Cystic Carcinoma DisGeNET Curated 1.495E-6 2.445E-4 2.033E-3 3.423E-3 10 185
15 umls:C0153381 Malignant neoplasm of mouth DisGeNET BeFree 2.888E-6 4.409E-4 3.666E-3 6.614E-3 14 410
16 umls:C0038356 Stomach Neoplasms DisGeNET Curated 4.755E-6 6.460E-4 5.371E-3 1.089E-2 15 490
17 umls:C0206682 Follicular thyroid carcinoma DisGeNET Curated 4.982E-6 6.460E-4 5.371E-3 1.141E-2 9 166
18 umls:C0043094 Weight Gain DisGeNET Curated 5.144E-6 6.460E-4 5.371E-3 1.178E-2 7 89
19 umls:C0151546 Oral Cavity Carcinoma DisGeNET BeFree 5.542E-6 6.460E-4 5.371E-3 1.269E-2 7 90
20 umls:C0024117 Chronic Obstructive Airway Disease DisGeNET Curated 5.642E-6 6.460E-4 5.371E-3 1.292E-2 15 497
21 umls:C0340643 Dissection of aorta DisGeNET BeFree 6.384E-6 6.962E-4 5.788E-3 1.462E-2 5 35
22 umls:C0027626 Neoplasm Invasiveness DisGeNET Curated 7.539E-6 7.847E-4 6.524E-3 1.726E-2 8 132
23 umls:C0494165 Secondary malignant neoplasm of liver DisGeNET BeFree 8.835E-6 8.768E-4 7.290E-3 2.023E-2 14 452
24 umls:C0017601 Glaucoma DisGeNET Curated 9.189E-6 8.768E-4 7.290E-3 2.104E-2 9 179
25 umls:C3539878 Triple Negative Breast Neoplasms DisGeNET BeFree 9.761E-6 8.941E-4 7.433E-3 2.235E-2 14 456
26 umls:C0023267 Fibroid Tumor DisGeNET Curated 1.219E-5 1.034E-3 8.597E-3 2.792E-2 11 287
27 umls:C0153690 Secondary malignant neoplasm of bone DisGeNET BeFree 1.219E-5 1.034E-3 8.597E-3 2.792E-2 11 287
28 umls:C0035309 Retinal Diseases DisGeNET Curated 1.433E-5 1.172E-3 9.742E-3 3.281E-2 11 292
29 umls:C0399440 Hereditary gingival fibromatosis DisGeNET Curated 1.735E-5 1.370E-3 1.139E-2 3.972E-2 4 21
30 umls:C0017612 Glaucoma, Open-Angle DisGeNET Curated 1.803E-5 1.376E-3 1.144E-2 4.129E-2 5 43
31 umls:C1511789 Desmoplastic DisGeNET BeFree 2.264E-5 1.672E-3 1.390E-2
5.183E-2
 6 75
32 umls:C1519670 Tumor Angiogenesis DisGeNET BeFree 3.312E-5 2.285E-3 1.900E-2
7.585E-2
 13 443
33 umls:C0410787 Hereditary Connective Tissue Disorder DisGeNET BeFree 3.502E-5 2.285E-3 1.900E-2
8.020E-2
 3 9
34 umls:C3811653 Experimental Organism Basal Cell Carcinoma DisGeNET BeFree 3.520E-5 2.285E-3 1.900E-2
8.060E-2
 10 265
35 umls:C0345967 Malignant mesothelioma DisGeNET Curated 3.520E-5 2.285E-3 1.900E-2
8.060E-2
 10 265
36 umls:C0025286 Meningioma DisGeNET Curated 3.592E-5 2.285E-3 1.900E-2
8.226E-2
 12 383
37 umls:C0042133 Uterine Fibroids DisGeNET Curated 3.736E-5 2.312E-3 1.922E-2
8.555E-2
 11 324
38 umls:C0007115 Malignant neoplasm of thyroid DisGeNET BeFree 4.169E-5 2.513E-3 2.089E-2
9.548E-2
 13 453
39 umls:C0278883 Metastatic melanoma DisGeNET BeFree 4.790E-5 2.720E-3 2.261E-2
1.097E-1
 11 333
40 umls:C0010036 Corneal dystrophy DisGeNET BeFree 4.910E-5 2.720E-3 2.261E-2
1.124E-1
 4 27
41 umls:C0037268 Skin Abnormalities DisGeNET Curated 4.910E-5 2.720E-3 2.261E-2
1.124E-1
 4 27
42 umls:C1709246 Non-Neoplastic Disorder DisGeNET BeFree 4.989E-5 2.720E-3 2.261E-2
1.142E-1
 13 461
43 umls:C0034067 Pulmonary Emphysema DisGeNET Curated 5.556E-5 2.864E-3 2.381E-2
1.272E-1
 8 174
44 umls:C0728829 Congenital pes cavus DisGeNET BeFree 5.754E-5 2.864E-3 2.381E-2
1.318E-1
 2 2
45 umls:C0018245 Groenouw's Dystrophies DisGeNET BeFree 5.754E-5 2.864E-3 2.381E-2
1.318E-1
 2 2
46 umls:C0042140 Uterine Prolapse DisGeNET BeFree 5.754E-5 2.864E-3 2.381E-2
1.318E-1
 2 2
47 umls:C0007766 Intracranial Aneurysm DisGeNET Curated 5.990E-5 2.918E-3 2.426E-2
1.372E-1
 6 89
48 umls:C1512409 Hepatocarcinogenesis DisGeNET BeFree 6.208E-5 2.962E-3 2.462E-2
1.422E-1
 13 471
49 umls:C0027659 Neoplasms, Experimental DisGeNET Curated 6.612E-5 3.090E-3 2.569E-2
1.514E-1
 5 56
50 umls:C0220650 Metastatic malignant neoplasm to brain DisGeNET BeFree 7.047E-5 3.227E-3 2.683E-2
1.614E-1
 7 133
Show 45 more annotations