Toppgene analysis for aggregated_1964_log, IC14, positive side

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1: GO: Molecular Function [Display Chart] 561 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0048029 monosaccharide binding 2.378E-15 1.334E-12 9.217E-12 1.334E-12 14 80
2 GO:0030246 carbohydrate binding 2.040E-11 5.722E-9 3.952E-8 1.144E-8 18 290
3 GO:0031418 L-ascorbic acid binding 1.187E-8 2.219E-6 1.533E-5 6.657E-6 6 21
4 GO:0005536 glucose binding 2.692E-6 3.776E-4 2.608E-3 1.510E-3 4 13
5 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors 9.322E-6 1.046E-3 7.225E-3 5.230E-3 6 61
6 GO:0051082 unfolded protein binding 1.939E-5 1.716E-3 1.186E-2 1.088E-2 7 103
7 GO:0031406 carboxylic acid binding 2.457E-5 1.716E-3 1.186E-2 1.379E-2 10 240
8 GO:0043177 organic acid binding 2.733E-5 1.716E-3 1.186E-2 1.533E-2 10 243
9 GO:0031545 peptidyl-proline 4-dioxygenase activity 2.753E-5 1.716E-3 1.186E-2 1.545E-2 3 8
10 GO:0019200 carbohydrate kinase activity 5.190E-5 2.911E-3 2.011E-2 2.911E-2 4 26
11 GO:0019842 vitamin binding 8.637E-5 4.038E-3 2.789E-2 4.845E-2 6 90
12 GO:0051213 dioxygenase activity 8.637E-5 4.038E-3 2.789E-2 4.845E-2 6 90
13 GO:0016829 lyase activity 1.807E-4 7.138E-3 4.931E-2
1.014E-1
 8 195
14 GO:0005006 epidermal growth factor-activated receptor activity 1.909E-4 7.138E-3 4.931E-2
1.071E-1
 2 3
15 GO:0008475 procollagen-lysine 5-dioxygenase activity 1.909E-4 7.138E-3 4.931E-2
1.071E-1
 2 3
16 GO:0004656 procollagen-proline 4-dioxygenase activity 3.797E-4 1.028E-2
7.098E-2
2.130E-1
 2 4
17 GO:0033300 dehydroascorbic acid transporter activity 3.797E-4 1.028E-2
7.098E-2
2.130E-1
 2 4
18 GO:0070815 peptidyl-lysine 5-dioxygenase activity 3.797E-4 1.028E-2
7.098E-2
2.130E-1
 2 4
19 GO:0004634 phosphopyruvate hydratase activity 3.797E-4 1.028E-2
7.098E-2
2.130E-1
 2 4
20 GO:0031543 peptidyl-proline dioxygenase activity 3.854E-4 1.028E-2
7.098E-2
2.162E-1
 4 43
21 GO:0016875 ligase activity, forming carbon-oxygen bonds 4.213E-4 1.028E-2
7.098E-2
2.363E-1
 4 44
22 GO:0004812 aminoacyl-tRNA ligase activity 4.213E-4 1.028E-2
7.098E-2
2.363E-1
 4 44
23 GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds 4.213E-4 1.028E-2
7.098E-2
2.363E-1
 4 44
24 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 5.535E-4 1.261E-2
8.713E-2
3.105E-1
 7 176
25 GO:0004340 glucokinase activity 6.295E-4 1.261E-2
8.713E-2
3.532E-1
 2 5
26 GO:0004396 hexokinase activity 6.295E-4 1.261E-2
8.713E-2
3.532E-1
 2 5
27 GO:0008865 fructokinase activity 6.295E-4 1.261E-2
8.713E-2
3.532E-1
 2 5
28 GO:0019158 mannokinase activity 6.295E-4 1.261E-2
8.713E-2
3.532E-1
 2 5
29 GO:0016830 carbon-carbon lyase activity 7.425E-4 1.436E-2
9.923E-2
4.166E-1
 4 51
30 GO:0055131 C3HC4-type RING finger domain binding 9.393E-4 1.756E-2
1.213E-1
5.269E-1
 2 6
31 GO:0051183 vitamin transporter activity 1.023E-3 1.852E-2
1.279E-1
5.740E-1
 3 25
32 GO:0042056 chemoattractant activity 1.588E-3 2.784E-2
1.923E-1
8.908E-1
 3 29
33 GO:0055056 D-glucose transmembrane transporter activity 1.735E-3 2.949E-2
2.037E-1
9.733E-1
 2 8
34 GO:0005506 iron ion binding 1.919E-3 3.166E-2
2.187E-1
1.000E0
 6 161
35 GO:0016832 aldehyde-lyase activity 2.219E-3 3.458E-2
2.389E-1
1.000E0
 2 9
36 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity 2.219E-3 3.458E-2
2.389E-1
1.000E0
 2 9
37 GO:0001968 fibronectin binding 2.316E-3 3.511E-2
2.426E-1
1.000E0
 3 33
38 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses 3.354E-3 4.952E-2
3.421E-1
1.000E0
 2 11
Show 33 more annotations

2: GO: Biological Process [Display Chart] 3010 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006007 glucose catabolic process 1.433E-17 3.280E-14 2.817E-13 4.312E-14 12 33
2 GO:0061621 canonical glycolysis 4.359E-17 3.280E-14 2.817E-13 1.312E-13 11 26
3 GO:0061718 glucose catabolic process to pyruvate 4.359E-17 3.280E-14 2.817E-13 1.312E-13 11 26
4 GO:0006735 NADH regeneration 4.359E-17 3.280E-14 2.817E-13 1.312E-13 11 26
5 GO:0061620 glycolytic process through glucose-6-phosphate 1.912E-16 1.151E-13 9.885E-13 5.756E-13 11 29
6 GO:0061615 glycolytic process through fructose-6-phosphate 2.999E-16 1.504E-13 1.292E-12 9.026E-13 11 30
7 GO:0006734 NADH metabolic process 5.783E-16 2.487E-13 2.135E-12 1.741E-12 12 43
8 GO:0019674 NAD metabolic process 2.566E-15 9.654E-13 8.290E-12 7.724E-12 13 63
9 GO:0019320 hexose catabolic process 1.199E-14 4.010E-12 3.444E-11 3.609E-11 12 54
10 GO:0070482 response to oxygen levels 4.150E-14 1.249E-11 1.073E-10 1.249E-10 22 339
11 GO:0001666 response to hypoxia 8.594E-14 2.352E-11 2.019E-10 2.587E-10 21 313
12 GO:0046365 monosaccharide catabolic process 1.072E-13 2.689E-11 2.309E-10 3.227E-10 12 64
13 GO:0036293 response to decreased oxygen levels 1.496E-13 3.348E-11 2.875E-10 4.504E-10 21 322
14 GO:0046031 ADP metabolic process 1.557E-13 3.348E-11 2.875E-10 4.688E-10 13 85
15 GO:0006090 pyruvate metabolic process 3.536E-13 7.095E-11 6.093E-10 1.064E-9 14 113
16 GO:0006165 nucleoside diphosphate phosphorylation 6.869E-13 1.292E-10 1.110E-9 2.068E-9 13 95
17 GO:0006096 glycolytic process 9.326E-13 1.651E-10 1.418E-9 2.807E-9 12 76
18 GO:0006757 ATP generation from ADP 1.097E-12 1.835E-10 1.576E-9 3.303E-9 12 77
19 GO:0009135 purine nucleoside diphosphate metabolic process 1.542E-12 2.320E-10 1.992E-9 4.640E-9 13 101
20 GO:0009179 purine ribonucleoside diphosphate metabolic process 1.542E-12 2.320E-10 1.992E-9 4.640E-9 13 101
21 GO:0046939 nucleotide phosphorylation 1.755E-12 2.515E-10 2.160E-9 5.282E-9 13 102
22 GO:0009185 ribonucleoside diphosphate metabolic process 2.905E-12 3.974E-10 3.413E-9 8.743E-9 13 106
23 GO:0009132 nucleoside diphosphate metabolic process 2.717E-11 3.556E-9 3.053E-8 8.178E-8 13 126
24 GO:0046128 purine ribonucleoside metabolic process 1.014E-10 1.272E-8 1.092E-7 3.053E-7 19 362
25 GO:0042278 purine nucleoside metabolic process 1.167E-10 1.405E-8 1.207E-7 3.513E-7 19 365
26 GO:0019362 pyridine nucleotide metabolic process 1.760E-10 1.962E-8 1.685E-7 5.298E-7 13 146
27 GO:0046496 nicotinamide nucleotide metabolic process 1.760E-10 1.962E-8 1.685E-7 5.298E-7 13 146
28 GO:0009119 ribonucleoside metabolic process 3.899E-10 4.185E-8 3.594E-7 1.174E-6 19 392
29 GO:0072524 pyridine-containing compound metabolic process 4.032E-10 4.185E-8 3.594E-7 1.214E-6 13 156
30 GO:0006733 oxidoreduction coenzyme metabolic process 5.110E-10 4.984E-8 4.280E-7 1.538E-6 13 159
31 GO:0006006 glucose metabolic process 5.133E-10 4.984E-8 4.280E-7 1.545E-6 15 229
32 GO:0005996 monosaccharide metabolic process 6.201E-10 5.833E-8 5.008E-7 1.866E-6 17 313
33 GO:0009167 purine ribonucleoside monophosphate metabolic process 9.293E-10 8.418E-8 7.229E-7 2.797E-6 16 279
34 GO:0009116 nucleoside metabolic process 9.708E-10 8.418E-8 7.229E-7 2.922E-6 19 414
35 GO:0009126 purine nucleoside monophosphate metabolic process 9.789E-10 8.418E-8 7.229E-7 2.946E-6 16 280
36 GO:0046034 ATP metabolic process 1.103E-9 9.223E-8 7.920E-7 3.320E-6 15 242
37 GO:0009161 ribonucleoside monophosphate metabolic process 1.711E-9 1.392E-7 1.195E-6 5.149E-6 16 291
38 GO:0006732 coenzyme metabolic process 1.825E-9 1.445E-7 1.241E-6 5.492E-6 17 336
39 GO:1901657 glycosyl compound metabolic process 2.285E-9 1.763E-7 1.514E-6 6.877E-6 19 436
40 GO:0044724 single-organism carbohydrate catabolic process 2.675E-9 2.013E-7 1.729E-6 8.052E-6 12 148
41 GO:0009123 nucleoside monophosphate metabolic process 3.207E-9 2.355E-7 2.022E-6 9.654E-6 16 304
42 GO:0009205 purine ribonucleoside triphosphate metabolic process 3.450E-9 2.473E-7 2.123E-6 1.039E-5 15 263
43 GO:0019318 hexose metabolic process 4.237E-9 2.966E-7 2.547E-6 1.275E-5 15 267
44 GO:0009199 ribonucleoside triphosphate metabolic process 4.930E-9 3.373E-7 2.896E-6 1.484E-5 15 270
45 GO:0009144 purine nucleoside triphosphate metabolic process 5.183E-9 3.433E-7 2.948E-6 1.560E-5 15 271
46 GO:0016052 carbohydrate catabolic process 5.246E-9 3.433E-7 2.948E-6 1.579E-5 12 157
47 GO:0071453 cellular response to oxygen levels 6.057E-9 3.879E-7 3.331E-6 1.823E-5 12 159
48 GO:0009141 nucleoside triphosphate metabolic process 1.622E-8 1.017E-6 8.736E-6 4.883E-5 15 295
49 GO:0006091 generation of precursor metabolites and energy 2.031E-8 1.248E-6 1.071E-5 6.113E-5 17 395
50 GO:0071456 cellular response to hypoxia 2.348E-8 1.414E-6 1.214E-5 7.068E-5 11 144
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 342 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043209 myelin sheath 5.085E-6 1.400E-3 8.977E-3 1.739E-3 10 204
2 GO:0005791 rough endoplasmic reticulum 8.185E-6 1.400E-3 8.977E-3 2.799E-3 7 92
3 GO:0043204 perikaryon 1.460E-4 1.572E-2
1.009E-1
 4.994E-2 7 144
4 GO:0016222 procollagen-proline 4-dioxygenase complex 1.839E-4 1.572E-2
1.009E-1
6.290E-2
 2 3
5 GO:0000015 phosphopyruvate hydratase complex 3.659E-4 2.503E-2
1.605E-1
1.251E-1
 2 4
6 GO:0031430 M band 7.556E-4 3.675E-2
2.357E-1
2.584E-1
 3 23
7 GO:0002080 acrosomal membrane 8.585E-4 3.675E-2
2.357E-1
2.936E-1
 3 24
8 GO:0005578 proteinaceous extracellular matrix 8.596E-4 3.675E-2
2.357E-1
2.940E-1
 10 379
9 GO:0044233 ER-mitochondrion membrane contact site 1.261E-3 4.792E-2
3.073E-1
4.313E-1
 2 7
Show 4 more annotations

4: Human Phenotype [Display Chart] 363 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0001082 Cholecystitis 3.566E-7 1.295E-4 8.380E-4 1.295E-4 4 8
2 HP:0001897 Normocytic anemia 6.320E-6 1.147E-3 7.425E-3 2.294E-3 3 5
3 HP:0001895 Normochromic anemia 1.256E-5 1.520E-3 9.839E-3 4.560E-3 3 6
4 HP:0001930 Nonspherocytic hemolytic anemia 2.185E-5 1.983E-3 1.283E-2 7.931E-3 3 7
5 HP:0000952 Jaundice {has synonym type="layperson"} 2.163E-4 1.570E-2
1.017E-1
7.852E-2
 5 64
6 HP:0003429 CNS hypomyelination 5.620E-4 3.400E-2
2.201E-1
2.040E-1
 3 19
7 HP:0002936 Distal sensory impairment 1.002E-3 4.439E-2
2.873E-1
3.638E-1
 5 89
8 HP:0003450 Axonal regeneration 1.118E-3 4.439E-2
2.873E-1
4.058E-1
 2 6
9 HP:0001081 Cholelithiasis 1.138E-3 4.439E-2
2.873E-1
4.133E-1
 3 24
10 HP:0002460 Distal muscle weakness 1.223E-3 4.439E-2
2.873E-1
4.439E-1
 5 93
11 HP:0001744 Splenomegaly 1.408E-3 4.647E-2
3.008E-1
5.111E-1
 7 196
Show 6 more annotations

5: Mouse Phenotype [Display Chart] 2430 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004847 abnormal liver weight 6.797E-6 1.652E-2
1.383E-1
 1.652E-2 12 215

6: Domain [Display Chart] 987 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00702 P4Hc SMART 1.294E-7 6.386E-5 4.772E-4 1.277E-4 5 16
2 IPR006620 Pro 4 hyd alph InterPro 1.294E-7 6.386E-5 4.772E-4 1.277E-4 5 16
3 PF03171 2OG-FeII Oxy Pfam 3.378E-7 1.112E-4 8.306E-4 3.335E-4 5 19
4 PS51471 FE2OG OXY PROSITE 5.836E-7 1.440E-4 1.076E-3 5.760E-4 5 21
5 IPR005123 Oxoglu/Fe-dep dioxygenase InterPro 9.525E-7 1.880E-4 1.405E-3 9.402E-4 5 23
6 PF06553 BNIP3 Pfam 6.453E-5 9.051E-3
6.763E-2
6.369E-2
 2 2
7 IPR010548 BNIP3 InterPro 6.453E-5 9.051E-3
6.763E-2
6.369E-2
 2 2
8 PF13640 2OG-FeII Oxy 3 Pfam 8.077E-5 9.051E-3
6.763E-2
7.972E-2
 3 11
9 PF08336 P4Ha N Pfam 1.926E-4 9.051E-3
6.763E-2
1.901E-1
 2 3
10 IPR020810 Enolase C InterPro 1.926E-4 9.051E-3
6.763E-2
1.901E-1
 2 3
11 IPR020809 Enolase CS InterPro 1.926E-4 9.051E-3
6.763E-2
1.901E-1
 2 3
12 PS01325 LYS HYDROXYLASE PROSITE 1.926E-4 9.051E-3
6.763E-2
1.901E-1
 2 3
13 PF03952 Enolase N Pfam 1.926E-4 9.051E-3
6.763E-2
1.901E-1
 2 3
14 PS00164 ENOLASE PROSITE 1.926E-4 9.051E-3
6.763E-2
1.901E-1
 2 3
15 IPR013547 Pro 4 hyd alph N InterPro 1.926E-4 9.051E-3
6.763E-2
1.901E-1
 2 3
16 SM01192 Enolase C SMART 1.926E-4 9.051E-3
6.763E-2
1.901E-1
 2 3
17 IPR000941 Enolase InterPro 1.926E-4 9.051E-3
6.763E-2
1.901E-1
 2 3
18 IPR020811 Enolase N InterPro 1.926E-4 9.051E-3
6.763E-2
1.901E-1
 2 3
19 PF00113 Enolase C Pfam 1.926E-4 9.051E-3
6.763E-2
1.901E-1
 2 3
20 IPR001006 Procol lys dOase InterPro 1.926E-4 9.051E-3
6.763E-2
1.901E-1
 2 3
21 SM01193 Enolase N SMART 1.926E-4 9.051E-3
6.763E-2
1.901E-1
 2 3
22 3.20.20.120 - Gene3D 3.831E-4 1.513E-2
1.130E-1
3.781E-1
 2 4
23 3.30.390.10 - Gene3D 3.831E-4 1.513E-2
1.130E-1
3.781E-1
 2 4
24 IPR029017 Enolase N-like InterPro 3.831E-4 1.513E-2
1.130E-1
3.781E-1
 2 4
25 IPR029065 Enolase C-like InterPro 3.831E-4 1.513E-2
1.130E-1
3.781E-1
 2 4
26 IPR022673 Hexokinase C InterPro 6.351E-4 1.900E-2
1.419E-1
6.269E-1
 2 5
27 PS00378 HEXOKINASE 1 PROSITE 6.351E-4 1.900E-2
1.419E-1
6.269E-1
 2 5
28 PF00349 Hexokinase 1 Pfam 6.351E-4 1.900E-2
1.419E-1
6.269E-1
 2 5
29 IPR009033 Calreticulin/calnexin P dom InterPro 6.351E-4 1.900E-2
1.419E-1
6.269E-1
 2 5
30 PF03727 Hexokinase 2 Pfam 6.351E-4 1.900E-2
1.419E-1
6.269E-1
 2 5
31 IPR019807 Hexokinase BS InterPro 6.351E-4 1.900E-2
1.419E-1
6.269E-1
 2 5
32 PS51748 HEXOKINASE 2 PROSITE 6.351E-4 1.900E-2
1.419E-1
6.269E-1
 2 5
33 IPR022672 Hexokinase N InterPro 6.351E-4 1.900E-2
1.419E-1
6.269E-1
 2 5
34 IPR001312 Hexokinase InterPro 9.476E-4 2.751E-2
2.056E-1
9.353E-1
 2 6
35 IPR015429 Cyclin L/T InterPro 1.750E-3 4.256E-2
3.180E-1
1.000E0
 2 8
36 3.20.20.80 - Gene3D 2.781E-3 4.256E-2
3.180E-1
1.000E0
 3 35
37 IPR018064 Metalthion vert metal BS InterPro 2.783E-3 4.256E-2
3.180E-1
1.000E0
 2 10
38 IPR013781 Glyco hydro catalytic dom InterPro 3.521E-3 4.256E-2
3.180E-1
1.000E0
 3 38
39 4.10.10.10 - Gene3D 4.039E-3 4.256E-2
3.180E-1
1.000E0
 2 12
40 IPR017854 Metalthion dom InterPro 4.039E-3 4.256E-2
3.180E-1
1.000E0
 2 12
41 IPR023587 Metalthion dom vert InterPro 4.039E-3 4.256E-2
3.180E-1
1.000E0
 2 12
42 3.20.20.70 - Gene3D 4.681E-3 4.256E-2
3.180E-1
1.000E0
 3 42
43 PS00203 METALLOTHIONEIN VRT PROSITE 4.749E-3 4.256E-2
3.180E-1
1.000E0
 2 13
44 IPR013785 Aldolase TIM InterPro 5.337E-3 4.256E-2
3.180E-1
1.000E0
 3 44
45 IPR003019 Metalthion InterPro 5.511E-3 4.256E-2
3.180E-1
1.000E0
 2 14
46 IPR000006 Metalthion vert InterPro 5.511E-3 4.256E-2
3.180E-1
1.000E0
 2 14
47 IPR003663 Sugar/inositol transpt InterPro 5.511E-3 4.256E-2
3.180E-1
1.000E0
 2 14
48 PF00131 Metallothio Pfam 5.511E-3 4.256E-2
3.180E-1
1.000E0
 2 14
49 PF00012 HSP70 Pfam 7.191E-3 4.256E-2
3.180E-1
1.000E0
 2 16
50 PS00608 GLYCOSYL HYDROL F2 2 PROSITE 8.060E-3 4.256E-2
3.180E-1
1.000E0
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 913 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 198814 Glycolysis and Gluconeogenesis BioSystems: WikiPathways 1.673E-15 1.446E-12 1.069E-11 1.528E-12 13 49
2 138045 HIF-1-alpha transcription factor network BioSystems: Pathway Interaction Database 3.168E-15 1.446E-12 1.069E-11 2.892E-12 14 65
3 413340 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate BioSystems: KEGG 2.961E-14 9.012E-12 6.664E-11 2.704E-11 10 25
4 695200 HIF-1 signaling pathway BioSystems: KEGG 2.197E-13 5.014E-11 3.708E-10 2.006E-10 15 106
5 PW:0000640 glycolysis pathway Pathway Ontology 2.839E-13 5.185E-11 3.834E-10 2.592E-10 9 21
6 105911 Glycolysis BioSystems: REACTOME 9.024E-12 1.373E-9 1.015E-8 8.239E-9 9 29
7 106199 Glucose metabolism BioSystems: REACTOME 1.406E-11 1.833E-9 1.356E-8 1.283E-8 12 75
8 82926 Glycolysis / Gluconeogenesis BioSystems: KEGG 6.552E-11 7.477E-9 5.529E-8 5.982E-8 11 66
9 MAP00010 Glycolysis Gluconeogenesis MAP00010 Glycolysis Gluconeogenesis GenMAPP 1.133E-10 1.149E-8 8.498E-8 1.034E-7 10 52
10 M15109 Glycolysis Pathway MSigDB C2 BIOCARTA (v5.1) 2.307E-10 2.106E-8 1.557E-7 2.106E-7 6 10
11 P00024 Glycolysis PantherDB 6.769E-10 5.618E-8 4.154E-7 6.180E-7 5 6
12 SMP00040 Glycolysis SMPDB 1.837E-9 1.398E-7 1.034E-6 1.677E-6 6 13
13 106196 Metabolism of carbohydrates BioSystems: REACTOME 2.024E-9 1.422E-7 1.051E-6 1.848E-6 17 266
14 814926 Carbon metabolism BioSystems: KEGG 2.940E-9 1.917E-7 1.418E-6 2.684E-6 11 93
15 413342 Gluconeogenesis, oxaloacetate => fructose-6P BioSystems: KEGG 1.281E-8 7.795E-7 5.764E-6 1.169E-5 6 17
16 PW:0000025 glycolysis/gluconeogenesis Pathway Ontology 1.453E-8 8.290E-7 6.130E-6 1.326E-5 7 29
17 SMP00128 Gluconeogenesis SMPDB 2.760E-8 1.482E-6 1.096E-5 2.520E-5 6 19
18 106204 Gluconeogenesis BioSystems: REACTOME 3.842E-8 1.949E-6 1.441E-5 3.508E-5 7 33
19 137956 HIF-2-alpha transcription factor network BioSystems: Pathway Interaction Database 4.796E-8 2.305E-6 1.704E-5 4.379E-5 7 34
20 790012 Biosynthesis of amino acids BioSystems: KEGG 5.966E-8 2.723E-6 2.014E-5 5.447E-5 9 73
21 MAP00500 Starch and sucrose metabolism MAP00500 Starch and sucrose metabolism GenMAPP 7.400E-8 3.217E-6 2.379E-5 6.756E-5 6 22
22 413341 Glycolysis, core module involving three-carbon compounds BioSystems: KEGG 8.498E-8 3.527E-6 2.608E-5 7.759E-5 5 12
23 PW:0000641 gluconeogenesis pathway Pathway Ontology 6.368E-7 2.423E-5 1.791E-4 5.814E-4 5 17
24 782396 glycolysis BioSystems: BIOCYC 6.368E-7 2.423E-5 1.791E-4 5.814E-4 5 17
25 167325 Protein processing in endoplasmic reticulum BioSystems: KEGG 1.276E-6 4.659E-5 3.445E-4 1.165E-3 11 167
26 82930 Fructose and mannose metabolism BioSystems: KEGG 1.715E-6 6.022E-5 4.453E-4 1.566E-3 6 36
27 MAP00051 Fructose and mannose metabolism MAP00051 Fructose and mannose metabolism GenMAPP 4.126E-6 1.395E-4 1.032E-3 3.767E-3 5 24
28 PW:0000041 fructose and mannose metabolic Pathway Ontology 1.864E-5 6.078E-4 4.494E-3 1.702E-2 4 16
29 82974 Starch and sucrose metabolism BioSystems: KEGG 2.412E-5 7.595E-4 5.616E-3 2.203E-2 6 56
30 835393 conversion of glucose to acetyl CoA and entry into the TCA cycle BioSystems: BIOCYC 3.798E-5 1.156E-3 8.546E-3 3.467E-2 5 37
31 645260 Regulation of Hypoxia-inducible Factor (HIF) by Oxygen BioSystems: REACTOME 1.645E-4 4.693E-3 3.470E-2
1.502E-1
 4 27
32 645259 Cellular response to hypoxia BioSystems: REACTOME 1.645E-4 4.693E-3 3.470E-2
1.502E-1
 4 27
33 SMP00064 Fructose and Mannose Degradation SMPDB 4.606E-4 1.274E-2
9.423E-2
4.205E-1
 3 15
34 905990 Glycogen synthesis BioSystems: REACTOME 5.626E-4 1.427E-2
1.055E-1
5.137E-1
 3 16
35 782382 gluconeogenesis BioSystems: BIOCYC 5.626E-4 1.427E-2
1.055E-1
5.137E-1
 3 16
36 MAP00710 Carbon fixation MAP00710 Carbon fixation GenMAPP 5.626E-4 1.427E-2
1.055E-1
5.137E-1
 3 16
37 PW:0000560 facilitative sugar transporter mediated glucose transport Pathway Ontology 6.399E-4 1.537E-2
1.137E-1
5.842E-1
 2 4
38 PW:0000021 hypertension Pathway Ontology 6.399E-4 1.537E-2
1.137E-1
5.842E-1
 2 4
39 MAP00030 Pentose phosphate pathway MAP00030 Pentose phosphate GenMAPP 6.780E-4 1.587E-2
1.174E-1
6.190E-1
 3 17
40 106200 Glucose transport BioSystems: REACTOME 7.716E-4 1.761E-2
1.302E-1
7.045E-1
 4 40
41 MAP00970 Aminoacyl tRNA biosynthesis MAP00970 Aminoacyl tRNA biosynthesis GenMAPP 8.074E-4 1.798E-2
1.329E-1
7.372E-1
 3 18
42 105980 tRNA Aminoacylation BioSystems: REACTOME 9.300E-4 2.020E-2
1.494E-1
8.491E-1
 4 42
43 SMP00058 Starch and Sucrose Metabolism SMPDB 9.515E-4 2.020E-2
1.494E-1
8.687E-1
 3 19
44 145809 Butirosin and neomycin biosynthesis BioSystems: KEGG 1.059E-3 2.198E-2
1.625E-1
9.670E-1
 2 5
45 106205 Pyruvate metabolism BioSystems: REACTOME 1.111E-3 2.205E-2
1.631E-1
1.000E0
 3 20
46 645262 Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha BioSystems: REACTOME 1.111E-3 2.205E-2
1.631E-1
1.000E0
 3 20
47 PW:0000151 starch and sucrose metabolic Pathway Ontology 1.286E-3 2.498E-2
1.847E-1
1.000E0
 3 21
48 106198 Hexose transport BioSystems: REACTOME 1.313E-3 2.498E-2
1.847E-1
1.000E0
 4 46
49 169351 Validated targets of C-MYC transcriptional activation BioSystems: Pathway Interaction Database 1.551E-3 2.770E-2
2.049E-1
1.000E0
 5 81
50 PW:0000360 the chronic hypoxic response - the hypoxia inducible factor - alpha Pathway Ontology 1.578E-3 2.770E-2
2.049E-1
1.000E0
 2 6
Show 45 more annotations

8: Pubmed [Display Chart] 34707 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 26641092 The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells. Pubmed 7.296E-16 2.532E-11 2.794E-10 2.532E-11 15 239
2 21081666 Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Pubmed 2.267E-15 3.933E-11 4.339E-10 7.867E-11 15 258
3 21319273 An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. Pubmed 4.532E-15 4.027E-11 4.443E-10 1.573E-10 17 397
4 25147182 Quantitative Lys-¿-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. Pubmed 5.339E-15 4.027E-11 4.443E-10 1.853E-10 17 401
5 15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Pubmed 5.802E-15 4.027E-11 4.443E-10 2.014E-10 16 336
6 22623428 Proteomic analysis of ¿4�1 integrin adhesion complexes reveals ¿-subunit-dependent protein recruitment. Pubmed 9.892E-15 5.722E-11 6.312E-10 3.433E-10 18 491
7 15952740 Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. Pubmed 1.257E-13 6.234E-10 6.878E-9 4.364E-9 9 58
8 19199708 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Pubmed 1.444E-13 6.265E-10 6.911E-9 5.012E-9 16 414
9 20849852 Proliferating cell nuclear antigen in the cytoplasm interacts with components of glycolysis and cancer. Pubmed 1.904E-13 7.342E-10 8.100E-9 6.608E-9 7 21
10 22304920 PKC¿ promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Pubmed 3.637E-13 1.262E-9 1.392E-8 1.262E-8 11 136
11 20000738 Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma. Pubmed 6.269E-13 1.978E-9 2.182E-8 2.176E-8 10 102
12 16009940 Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. Pubmed 1.242E-12 3.591E-9 3.962E-8 4.310E-8 11 152
13 16236267 Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. Pubmed 2.048E-12 5.468E-9 6.033E-8 7.109E-8 9 78
14 25192599 Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. Pubmed 2.895E-11 6.740E-8 7.435E-7 1.005E-6 11 203
15 16263121 A proteomic snapshot of the human heat shock protein 90 interactome. Pubmed 2.913E-11 6.740E-8 7.435E-7 1.011E-6 7 40
16 24332808 PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Pubmed 3.460E-11 7.506E-8 8.281E-7 1.201E-6 13 340
17 22190034 Global landscape of HIV-human protein complexes. Pubmed 1.101E-10 2.247E-7 2.479E-6 3.820E-6 14 457
18 20029029 Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Pubmed 1.415E-10 2.728E-7 3.010E-6 4.911E-6 8 82
19 23125841 Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1. Pubmed 1.816E-10 3.317E-7 3.659E-6 6.302E-6 11 241
20 16027165 Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins. Pubmed 3.348E-10 5.810E-7 6.410E-6 1.162E-5 6 30
21 24337577 Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. Pubmed 4.685E-10 7.743E-7 8.543E-6 1.626E-5 10 198
22 25324306 hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. Pubmed 6.129E-10 9.669E-7 1.067E-5 2.127E-5 12 346
23 16502470 Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Pubmed 1.378E-9 2.079E-6 2.294E-5 4.782E-5 9 160
24 25468996 E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Pubmed 2.319E-9 3.353E-6 3.699E-5 8.047E-5 11 307
25 18977241 Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. Pubmed 2.656E-9 3.520E-6 3.884E-5 9.217E-5 8 118
26 18977241:gr Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. GeneRIF 2.656E-9 3.520E-6 3.884E-5 9.217E-5 8 118
27 17601350 A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. Pubmed 2.840E-9 3.520E-6 3.884E-5 9.857E-5 8 119
28 17601350:gr A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. GeneRIF 2.840E-9 3.520E-6 3.884E-5 9.857E-5 8 119
29 21044950 Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Pubmed 4.907E-9 5.873E-6 6.479E-5 1.703E-4 11 330
30 20562859 Network organization of the human autophagy system. Pubmed 7.364E-9 8.360E-6 9.223E-5 2.556E-4 12 432
31 19135240 Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. Pubmed 7.495E-9 8.360E-6 9.223E-5 2.601E-4 7 86
32 23874603 HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis. Pubmed 7.708E-9 8.360E-6 9.223E-5 2.675E-4 8 135
33 19554504:gr Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma. GeneRIF 9.077E-9 9.266E-6 1.022E-4 3.150E-4 4 9
34 19554504 Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma. Pubmed 9.077E-9 9.266E-6 1.022E-4 3.150E-4 4 9
35 20347420:gr A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis. GeneRIF 2.519E-8 1.943E-5 2.143E-4 8.742E-4 3 3
36 19681047:gr Kinetics of transport and phosphorylation of glucose in cancer cells. GeneRIF 2.519E-8 1.943E-5 2.143E-4 8.742E-4 3 3
37 19049977:gr Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity. GeneRIF 2.519E-8 1.943E-5 2.143E-4 8.742E-4 3 3
38 25658354 Caveolin-1, galectin-3 and lipid raft domains in cancer cell signalling. Pubmed 2.519E-8 1.943E-5 2.143E-4 8.742E-4 3 3
39 19681047 Kinetics of transport and phosphorylation of glucose in cancer cells. Pubmed 2.519E-8 1.943E-5 2.143E-4 8.742E-4 3 3
40 17387692:gr An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach. GeneRIF 2.519E-8 1.943E-5 2.143E-4 8.742E-4 3 3
41 17387692 An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach. Pubmed 2.519E-8 1.943E-5 2.143E-4 8.742E-4 3 3
42 11688991:gr Identification of genes differentially induced by hypoxia in pancreatic cancer cells. GeneRIF 2.519E-8 1.943E-5 2.143E-4 8.742E-4 3 3
43 17684156 Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor. Pubmed 2.519E-8 1.943E-5 2.143E-4 8.742E-4 3 3
44 20347420 A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis. Pubmed 2.519E-8 1.943E-5 2.143E-4 8.742E-4 3 3
45 11688991 Identification of genes differentially induced by hypoxia in pancreatic cancer cells. Pubmed 2.519E-8 1.943E-5 2.143E-4 8.742E-4 3 3
46 23798571 Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. Pubmed 2.916E-8 2.200E-5 2.428E-4 1.012E-3 8 160
47 20473970 Identification of FBXO25-interacting proteins using an integrated proteomics approach. Pubmed 4.740E-8 3.500E-5 3.862E-4 1.645E-3 7 112
48 24797263 Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. Pubmed 5.002E-8 3.617E-5 3.990E-4 1.736E-3 10 323
49 21630459 Proteomic characterization of the human sperm nucleus. Pubmed 8.585E-8 6.081E-5 6.708E-4 2.980E-3 11 437
50 22901702:gr Biologic correlation between glucose transporters, hexokinase-II, Ki-67 and FDG uptake in malignant melanoma. GeneRIF 1.005E-7 6.462E-5 7.129E-4 3.489E-3 3 4
Show 45 more annotations

9: Interaction [Display Chart] 4367 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ENO1 ENO1 interactions 1.412E-11 6.167E-8 5.525E-7 6.167E-8 19 291
2 int:TKT TKT interactions 2.347E-9 5.125E-6 4.592E-5 1.025E-5 12 132
3 int:ISG15 ISG15 interactions 5.369E-9 6.137E-6 5.498E-5 2.345E-5 14 208
4 int:HUWE1 HUWE1 interactions 5.621E-9 6.137E-6 5.498E-5 2.455E-5 20 462
5 int:ENO3 ENO3 interactions 7.977E-9 6.967E-6 6.242E-5 3.484E-5 8 47
6 int:SOD1 SOD1 interactions 1.464E-8 1.041E-5 9.331E-5 6.392E-5 12 155
7 int:HDAC5 HDAC5 interactions 1.669E-8 1.041E-5 9.331E-5 7.290E-5 17 351
8 int:U2AF2 U2AF2 interactions 2.142E-8 1.169E-5 1.048E-4 9.354E-5 17 357
9 int:SUMO4 SUMO4 interactions 3.903E-8 1.894E-5 1.697E-4 1.704E-4 9 80
10 int:TPI1 TPI1 interactions 1.610E-7 7.030E-5 6.298E-4 7.030E-4 9 94
11 int:ATF2 ATF2 interactions 5.587E-7 2.218E-4 1.987E-3 2.440E-3 12 216
12 int:NDRG1 NDRG1 interactions 6.225E-7 2.265E-4 2.029E-3 2.718E-3 9 110
13 int:H2AFX H2AFX interactions 8.225E-7 2.763E-4 2.475E-3 3.592E-3 12 224
14 int:KCNMA1 KCNMA1 interactions 9.112E-7 2.842E-4 2.547E-3 3.979E-3 11 186
15 int:ALDOA ALDOA interactions 1.128E-6 3.284E-4 2.942E-3 4.926E-3 9 118
16 int:AKT1 AKT1 interactions 1.244E-6 3.395E-4 3.041E-3 5.432E-3 14 323
17 int:PDIA3 PDIA3 interactions 1.393E-6 3.579E-4 3.207E-3 6.085E-3 9 121
18 int:PGK1 PGK1 interactions 1.827E-6 4.431E-4 3.970E-3 7.977E-3 8 93
19 int:PCNA PCNA interactions 2.531E-6 5.653E-4 5.064E-3 1.105E-2 13 295
20 int:VCAM1 VCAM1 interactions 2.589E-6 5.653E-4 5.064E-3 1.131E-2 16 447
21 int:CUL2 CUL2 interactions 2.986E-6 5.931E-4 5.314E-3 1.304E-2 16 452
22 int:ALDOC ALDOC interactions 2.988E-6 5.931E-4 5.314E-3 1.305E-2 7 70
23 int:AKR1B1 AKR1B1 interactions 3.240E-6 6.152E-4 5.512E-3 1.415E-2 6 46
24 int:ADRB2 ADRB2 interactions 3.459E-6 6.293E-4 5.638E-3 1.510E-2 12 257
25 int:PKM PKM interactions 3.948E-6 6.896E-4 6.179E-3 1.724E-2 10 175
26 int:TERF1 TERF1 interactions 4.513E-6 7.581E-4 6.792E-3 1.971E-2 13 311
27 int:STIP1 STIP1 interactions 5.254E-6 8.498E-4 7.613E-3 2.294E-2 9 142
28 int:CFL1 CFL1 interactions 1.071E-5 1.670E-3 1.496E-2 4.677E-2 9 155
29 int:MIF MIF interactions 1.282E-5 1.930E-3 1.729E-2
5.598E-2
 6 58
30 int:ENO2 ENO2 interactions 1.384E-5 2.014E-3 1.804E-2
6.042E-2
 7 88
31 int:PPME1 PPME1 interactions 1.725E-5 2.430E-3 2.177E-2
7.533E-2
 7 91
32 int:DYNLL1 DYNLL1 interactions 1.803E-5 2.456E-3 2.200E-2
7.875E-2
 10 208
33 int:HIF1A HIF1A interactions 1.856E-5 2.456E-3 2.200E-2
8.104E-2
 9 166
34 int:P4HB P4HB interactions 2.085E-5 2.678E-3 2.400E-2
9.106E-2
 8 129
35 int:HSPA9 HSPA9 interactions 2.213E-5 2.761E-3 2.474E-2
9.665E-2
 10 213
36 int:STAU1 STAU1 interactions 2.291E-5 2.779E-3 2.490E-2
1.000E-1
 12 310
37 int:CRIP1 CRIP1 interactions 2.745E-5 3.155E-3 2.826E-2
1.199E-1
 5 40
38 int:GPX4 GPX4 interactions 2.745E-5 3.155E-3 2.826E-2
1.199E-1
 5 40
39 int:HSP90AB1 HSP90AB1 interactions 2.942E-5 3.294E-3 2.951E-2
1.285E-1
 12 318
40 int:ALDH4A1 ALDH4A1 interactions 3.277E-5 3.578E-3 3.205E-2
1.431E-1
 4 21
41 int:RPA3 RPA3 interactions 3.880E-5 4.133E-3 3.703E-2
1.695E-1
 13 381
42 int:FUS FUS interactions 3.978E-5 4.136E-3 3.706E-2
1.737E-1
 12 328
43 int:RPA2 RPA2 interactions 4.480E-5 4.550E-3 4.076E-2
1.956E-1
 14 443
44 int:TCTN1 TCTN1 interactions 4.934E-5 4.897E-3 4.387E-2
2.155E-1
 7 107
45 int:BCAP31 BCAP31 interactions 5.217E-5 5.062E-3 4.536E-2
2.278E-1
 6 74
46 int:FBXO25 FBXO25 interactions 6.308E-5 5.989E-3
5.366E-2
2.755E-1
 9 194
47 int:LGALS1 LGALS1 interactions 8.098E-5 7.332E-3
6.568E-2
3.536E-1
 6 80
48 int:FH FH interactions 8.098E-5 7.332E-3
6.568E-2
3.536E-1
 6 80
49 int:GBAS GBAS interactions 8.226E-5 7.332E-3
6.568E-2
3.592E-1
 5 50
50 int:BCL2L11 BCL2L11 interactions 9.055E-5 7.809E-3
6.996E-2
3.954E-1
 5 51
Show 45 more annotations

10: Cytoband [Display Chart] 134 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6q24-q25 6q24-q25 1.894E-4 2.538E-2
1.391E-1
 2.538E-2 2 5
2 9q33 9q33 5.258E-4 3.523E-2
1.930E-1
7.045E-2
 2 8

11: Transcription Factor Binding Site [Display Chart] 474 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$HIF1 Q3 V$HIF1 Q3 4.173E-5 1.978E-2
1.333E-1
 1.978E-2 10 183

12: Gene Family [Display Chart] 72 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 132 Aminoacyl tRNA synthetases, Class II genenames.org 9.355E-5 6.735E-3 3.274E-2 6.735E-3 3 19

13: Coexpression [Display Chart] 6416 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M9197 Genes up-regulated in MCF7 cells (breast cancer) treated with hypoxia mimetic DMOG [PubChem=3080614]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.602E-46 1.028E-42 9.602E-42 1.028E-42 35 130
2 M5891 Genes up-regulated in response to low oxygen levels (hypoxia). MSigDB H: Hallmark Gene Sets (v5.1) 7.659E-46 2.457E-42 2.296E-41 4.914E-42 39 200
3 M6189 Genes down-regulated in MCF7 cells (breast cancer) after knockdown of both HIF1A and HIF2A [GeneID=3091;2034] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.167E-44 2.497E-41 2.333E-40 7.490E-41 32 104
4 M7363 Genes up-regulated in MCF7 cells (breast cancer) under hypoxia conditions. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.997E-42 1.122E-38 1.049E-37 4.489E-38 35 171
5 M2513 Genes down-regulated in MCF7 cells (breast cancer) after knockdown of HIF1A [GeneID=3091] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.331E-41 6.841E-38 6.392E-37 3.420E-37 29 91
6 M11033 Hypoxia response genes up-regulated in both astrocytes and HeLa cell line. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.579E-40 7.035E-37 6.573E-36 4.221E-36 29 98
7 M2345 Genes in the hypoxia signature, based on analysis of 11 neuroblastoma cell lines in hypoxia and normal oxygen conditions. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.002E-33 9.182E-31 8.580E-30 6.427E-30 19 32
8 M2133 Genes up-regulated by hypoxia in TRAMP-C cells (prostatic cancer). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.403E-31 1.125E-28 1.051E-27 9.001E-28 27 140
9 M14072 Genes regulated by hypoxia, based on literature searches. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.001E-30 1.427E-27 1.333E-26 1.284E-26 31 242
10 M5333 Genes down-regulated in comparison of control polymorphonuclear leukocytes (PMN) at 6 h versus PMN treated with F. tularensis vaccine at 6 h. MSigDB C7: Immunologic Signatures (v5.1) 1.101E-28 7.062E-26 6.598E-25 7.062E-25 28 199
11 M1570 Genes up-regulated in non-apoptotic tissues (fetal liver) after MDM4 [GeneID=4194] knockout. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.918E-28 1.119E-25 1.046E-24 1.231E-24 29 227
12 M5681 Genes up-regulated in apoptotic tissues (neuroepithelium) after MDM4 [GeneID=4194] knockout. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.482E-24 1.327E-21 1.240E-20 1.592E-20 24 176
13 M259 Genes up-regulated in response to both hypoxia and overexpression of an active form of HIF1A [GeneID=3091]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.731E-24 2.828E-21 2.643E-20 3.677E-20 25 207
14 M19622 Genes up-regulated in HK-2 cells kidney tubular epithelium) under hypoxia and down-regulated on re-oxygenation. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.652E-23 7.571E-21 7.074E-20 1.060E-19 16 47
15 M5924 Genes up-regulated through activation of mTORC1 complex. MSigDB H: Hallmark Gene Sets (v5.1) 5.719E-23 2.446E-20 2.286E-19 3.669E-19 24 200
16 M10508 Genes known to be induced by hypoxia MSigDB C2: CGP Curated Gene Sets (v5.1) 1.604E-22 6.431E-20 6.009E-19 1.029E-18 18 81
17 M12299 Genes that are transcriptionally regulated by HIF1A [GeneID=3091]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.110E-21 4.190E-19 3.915E-18 7.123E-18 14 36
18 M5937 Genes encoding proteins involved in glycolysis and gluconeogenesis. MSigDB H: Hallmark Gene Sets (v5.1) 1.298E-21 4.626E-19 4.323E-18 8.327E-18 23 200
19 M5466 Genes up-regulated in head and neck tumor samples which clustered around known hypoxia genes. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.934E-21 6.531E-19 6.102E-18 1.241E-17 18 92
20 GSE21360 SECONDARY VS QUATERNARY MEMORY CD8 TCELL DN Genes down-regulated in memory CD8 T cells: 2' versus 4'. MSigDB C7: Immunologic Signatures (v5.1) 6.444E-21 2.067E-18 1.932E-17 4.135E-17 21 162
21 M2183 Adipogenic genes (group 2) that are selectively repressed by SIRT1 [GeneID=23411] in mature 3T3-L1 adipocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.262E-19 6.910E-17 6.456E-16 1.451E-15 12 28
22 M5330 Genes down-regulated in comparison of control polymorphonuclear leukocytes (PMN) at 3 h versus PMN treated with F. tularensis vaccine at 3 h. MSigDB C7: Immunologic Signatures (v5.1) 3.694E-19 1.077E-16 1.007E-15 2.370E-15 21 196
23 M1496 Genes up-regulated in normal fibroblasts under hypoxia conditions. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.198E-18 1.390E-15 1.298E-14 3.335E-14 11 25
24 M1307 Genes down-regulated in SEND cells (skin endothelium) at normal oxygen (normoxia) conditions after knockdown of HIF1A [GeneID=3091] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.198E-18 1.390E-15 1.298E-14 3.335E-14 11 25
25 M3996 Genes up-regulated in RPTEC cells (normal kidney) by hypoxia. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.664E-17 6.836E-15 6.388E-14 1.709E-13 23 310
26 M1317 Genes up-regulated in SEND cells (skin endothelium) at hypoxia after knockdown of ELK3 [GeneID=2004] and HIF1A [GeneID=3091] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.588E-16 3.918E-14 3.661E-13 1.019E-12 17 142
27 M6476 Genes up-regulated in T cells: CD8A [GeneID=925] versus CD8A CD8B [GeneID=925;926]. MSigDB C7: Immunologic Signatures (v5.1) 1.935E-16 4.435E-14 4.144E-13 1.242E-12 19 200
28 M6941 Genes down-regulated in B lymphocytes: CpG oligodeoxynucleotide 1826 versus anti IgM and CpG oligodeoxynucleotide 1826. MSigDB C7: Immunologic Signatures (v5.1) 1.935E-16 4.435E-14 4.144E-13 1.242E-12 19 200
29 M1309 Genes down-regulated in SEND cells (skin endothelium) at hypoxia after knockdown of HIF1A [GeneID=3091] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.412E-15 3.123E-13 2.918E-12 9.058E-12 15 110
30 M5335 Genes down-regulated in comparison of control polymorphonuclear leukocytes (PMN) at 12 h versus PMN treated with F. tularensis vaccine at 12 h. MSigDB C7: Immunologic Signatures (v5.1) 2.984E-15 6.381E-13 5.963E-12 1.914E-11 18 199
31 M5784 IRF4 [GeneID=3662] target genes up-regulated in primary myeloma vs. mature B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.021E-14 2.113E-12 1.975E-11 6.552E-11 14 101
32 M5353 Genes down-regulated in comparison of control polymorphonuclear leukocytes (PMN) at 0 h versus PMN treated with F. tularensis vaccine at 48 h. MSigDB C7: Immunologic Signatures (v5.1) 3.999E-14 8.018E-12 7.492E-11 2.566E-10 17 197
33 GSE32986 UNSTIM VS GMCSF AND CURDLAN LOWDOSE STIM DC UP Genes up-regulated in bone marrow-derived dendritic cells: unstimulated versus CSF2 [GeneID=1437] and low dose of 1,3-beta-D-oligoglucan [PubChem=11375554]. MSigDB C7: Immunologic Signatures (v5.1) 5.136E-14 9.986E-12 9.331E-11 3.296E-10 17 200
34 M14958 Genes up-regulated in ACC3 cells (adenoid cystic carcinoma) after knockdown of SOX4 [GeneID=6659] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.001E-14 1.132E-11 1.058E-10 3.850E-10 11 52
35 M1784 Genes changed in U373-MG cells (malignant glioma) upon treatment with arsenic trioxide [PubChem=14888], a chemical that can cause autophagic cell death. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.686E-13 3.091E-11 2.888E-10 1.082E-9 14 123
36 GSE16450 CTRL VS IFNA 12H STIM IMMATURE NEURON CELL LINE DN Genes down-regulated in immature neuron cell line: control versus interferon alpha (12h). MSigDB C7: Immunologic Signatures (v5.1) 3.409E-13 6.076E-11 5.677E-10 2.187E-9 16 190
37 M3237 Genes down-regulated in comparison of memory CD4 [GeneID=920] T cells treated with retinoic acid (tretinoin) [PubChem=444795] versus untreated memory CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v5.1) 7.550E-13 1.309E-10 1.223E-9 4.844E-9 16 200
38 M2371 Genes down-regulated by VHL [GeneID=7428] and re-expressed under hypoxia conditions in renal carcinoma cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.131E-12 1.909E-10 1.784E-9 7.253E-9 7 13
39 M1304 Genes down-regulated in SEND cells (skin endothelium) at hypoxia with ELK3 [GeneID=2004] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.570E-12 7.518E-10 7.025E-9 2.932E-8 14 156
40 M11189 IRF4 [GeneID=3662] target genes induced after activation of primary B lymphocytes by anti-IgM crosslinking. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.014E-11 1.615E-9 1.509E-8 6.507E-8 11 81
41 M5338 Genes down-regulated in comparison of control polymorphonuclear leukocytes (PMN) at 24 h versus PMN treated with F. tularensis vaccine at 24 h. MSigDB C7: Immunologic Signatures (v5.1) 1.032E-11 1.615E-9 1.509E-8 6.621E-8 15 200
42 M9788 Genes up-regulated in differentiating C2C12 cells (myoblasts) upon expression of PPARGC1A [GeneID=10891] off an adenoviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.406E-11 2.148E-9 2.007E-8 9.021E-8 20 420
43 M11197 Housekeeping genes identified as expressed across 19 normal tissues. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.061E-11 4.567E-9 4.267E-8 1.964E-7 19 389
44 M12037 IRF4 [GeneID=3662] target genes up-regulated in plasma cells compared to mature B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.451E-11 5.032E-9 4.702E-8 2.214E-7 10 67
45 M16111 Genes involved in glycolysis; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.312E-11 1.043E-8 9.741E-8 4.692E-7 7 21
46 M1098 Genes down-regulated in ME-A cells (breast cancer) undergoing apoptosis upon serum starvation (5% to 0% FCS) for 22 hr. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.633E-11 1.344E-8 1.255E-7 6.181E-7 15 234
47 M5346 Genes down-regulated in comparison of control polymorphonuclear leukocytes (PMN) at 0 h versus PMN treated with F. tularensis vaccine at 6 h. MSigDB C7: Immunologic Signatures (v5.1) 1.143E-10 1.560E-8 1.458E-7 7.334E-7 14 198
48 M5203 Genes up-regulated in comparison of dendritic cells (DC) exposed to L. donovani versus DCs exposed to 5 worm/well B. malayi. MSigDB C7: Immunologic Signatures (v5.1) 1.222E-10 1.600E-8 1.495E-7 7.842E-7 14 199
49 M5235 Genes up-regulated in comparison of macrophages exposed to L. donovani versus macrophages exposed to 50 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v5.1) 1.222E-10 1.600E-8 1.495E-7 7.842E-7 14 199
50 GSE28726 NAIVE CD4 TCELL VS NAIVE VA24NEG NKTCELL UP Genes up-regulated in naïve T cells: CD4 [GeneID=920] versus Va24- NKT. MSigDB C7: Immunologic Signatures (v5.1) 1.307E-10 1.644E-8 1.536E-7 8.383E-7 14 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2687 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 26Dn SubClass 26Dn 2 Top 500 All 26Dn SubClass 26Dn 2 Top 500 All Brain Map - Allen iN 3.261E-19 8.761E-16 7.424E-15 8.761E-16 30 498
2 54Dn SubClass 54Dn 2 Top 500 All 54Dn SubClass 54Dn 2 Top 500 All Brain Map - Allen iN 2.366E-14 3.179E-11 2.694E-10 6.358E-11 25 495
3 54Dn Top 500 All 54Dn Top 500 All Brain Map - Allen iN 8.146E-11 6.119E-8 5.185E-7 2.189E-7 21 493
4 26Dn Top 500 All 26Dn Top 500 All Brain Map - Allen iN 9.109E-11 6.119E-8 5.185E-7 2.447E-7 21 496
5 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 5.784E-10 3.108E-7 2.634E-6 1.554E-6 20 494
6 endothelial Top 500 Cluster 1 endothelial Top 500 Cluster 1 Brain Map - Barres 1.693E-9 7.584E-7 6.426E-6 4.550E-6 7 30
7 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 3.990E-9 1.532E-6 1.298E-5 1.072E-5 19 496
8 Facebase ST1 e8.5 ParaxMesoderm 500 e8.5 ParaxMesoderm top-relative-expression-ranked 500 FaceBase_ST1 1.378E-8 4.627E-6 3.921E-5 3.702E-5 17 423
9 Facebase ST1 e8.5 ParaxMesoderm 500 1 e8.5 ParaxMesoderm top-relative-expression-ranked 500 1 FaceBase_ST1 1.983E-8 5.795E-6 4.911E-5 5.328E-5 13 236
10 Lungmap Mouse e16.5 Epithelial Top 500 Cluster 4 Mouse Lung E16.5 Epithelial top 500 c4 Lungmap Mouse Single Cell (Lungmap.net) 2.157E-8 5.795E-6 4.911E-5 5.795E-5 6 25
11 astrocytes Top 500 All astrocytes Top 500 All Brain Map - Barres 2.418E-8 5.905E-6 5.004E-5 6.496E-5 18 496
12 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 3.747E-8 7.778E-6 6.591E-5 1.007E-4 17 453
13 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 3.994E-8 7.778E-6 6.591E-5 1.073E-4 17 455
14 Facebase ST1 e8.5 ParaxMesoderm 250 e8.5 ParaxMesoderm top-relative-expression-ranked 250 FaceBase_ST1 4.053E-8 7.778E-6 6.591E-5 1.089E-4 12 207
15 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.658E-8 1.013E-5 8.588E-5 1.520E-4 16 410
16 GSM777059 500 Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.438E-7 2.415E-5 2.046E-4 3.864E-4 16 439
17 26Dn SubClass 26Dn 2 Top 500 Cluster 4 26Dn SubClass 26Dn 2 Top 500 Cluster 4 Brain Map - Allen iN 1.950E-7 2.999E-5 2.541E-4 5.241E-4 9 117
18 GSM777063 500 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 2.009E-7 2.999E-5 2.541E-4 5.398E-4 16 450
19 Lungmap Mouse e16.5 Epithelial SubClass Noncycling AT2 Precursor Top 500 All Mouse Lung E16.5 Epithelial Noncycling AT2 Precursor top 500 Lungmap Mouse Single Cell (Lungmap.net) 2.136E-7 3.021E-5 2.560E-4 5.740E-4 15 395
20 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 2.779E-7 3.733E-5 3.164E-4 7.467E-4 16 461
21 PCBC ratio MESO-30 vs MESO-15 cfr-2X-p05 Mesoderm Day 30 vs Mesoderm Day 15-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 4.271E-7 5.363E-5 4.544E-4 1.148E-3 6 40
22 GSM854338 500 Myeloid Cells, GN.Arth.SynF, CD11b+ Ly6-G+, Synovial Fluid, avg-3 Immgen.org, GSE15907 4.391E-7 5.363E-5 4.544E-4 1.180E-3 15 418
23 54Dn SubClass 54Dn 2 Top 500 Cluster 2 54Dn SubClass 54Dn 2 Top 500 Cluster 2 Brain Map - Allen iN 7.352E-7 8.586E-5 7.275E-4 1.975E-3 5 24
24 80Dn Top 500 Cluster 0 80Dn Top 500 Cluster 0 Brain Map - Allen iN 7.669E-7 8.586E-5 7.275E-4 2.061E-3 6 44
25 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 9.638E-7 1.036E-4 8.778E-4 2.590E-3 15 445
26 Facebase ST1 e8.5 NeuroEpith FloorPlate 500 2 e8.5 NeuroEpith FloorPlate top-relative-expression-ranked 500 2 FaceBase_ST1 1.051E-6 1.072E-4 9.086E-4 2.824E-3 13 333
27 Lungmap Mouse e16.5 Epithelial Top 500 All Mouse Lung E16.5 Epithelial top 500 Lungmap Mouse Single Cell (Lungmap.net) 1.077E-6 1.072E-4 9.086E-4 2.895E-3 15 449
28 GSM538280 500 Myeloid Cells, DC.LC.Sk, MHCII+ CD11b+ CD45+, Skin, avg-2 Immgen.org, GSE15907 1.170E-6 1.123E-4 9.517E-4 3.145E-3 15 452
29 Facebase RNAseq e8.5 Hind Brain Neural Epithelium 1000 K3 FacebaseRNAseq e8.5 Hind Brain Neural Epithelium top-relative-expression-ranked 1000 k-means-cluster#3 FaceBase_RNAseq 1.266E-6 1.173E-4 9.936E-4 3.401E-3 12 285
30 Lungmap Mouse e18.5 Epithelial (GSE52583) SubClass Bi-potential Top 500 All Mouse Lung E18.5 Epithelial Bi-potential top 500 Lungmap Mouse Single Cell (Lungmap.net) 1.542E-6 1.381E-4 1.170E-3 4.143E-3 14 402
31 JC fibro 1000 K1 JC fibro top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 1.619E-6 1.403E-4 1.189E-3 4.350E-3 15 464
32 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 1.753E-6 1.472E-4 1.247E-3 4.709E-3 15 467
33 26Dn Top 500 Cluster 4 26Dn Top 500 Cluster 4 Brain Map - Allen iN 2.108E-6 1.716E-4 1.454E-3 5.664E-3 6 52
34 Facebase RNAseq e8.5 Hind Brain Neural Epithelium 500 K1 FacebaseRNAseq e8.5 Hind Brain Neural Epithelium top-relative-expression-ranked 500 k-means-cluster#1 FaceBase_RNAseq 2.332E-6 1.843E-4 1.562E-3 6.266E-3 9 157
35 54SK Top 500 All 54SK Top 500 All Brain Map - Allen iN 3.004E-6 2.306E-4 1.954E-3 8.071E-3 15 488
36 Facebase RNAseq e8.5 Hind Brain Neural Epithelium 500 FacebaseRNAseq e8.5 Hind Brain Neural Epithelium top-relative-expression-ranked 500 FaceBase_RNAseq 3.660E-6 2.732E-4 2.315E-3 9.834E-3 15 496
37 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 4.171E-6 3.029E-4 2.567E-3 1.121E-2 14 438
38 GSM605862 500 Myeloid Cells, MF.Thio5.II-480hi.PC, CD115+ MHC II- F480hi Siglec F-, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 4.511E-6 3.190E-4 2.703E-3 1.212E-2 14 441
39 54Dn SubClass 54Dn 2 Top 500 Cluster 0 54Dn SubClass 54Dn 2 Top 500 Cluster 0 Brain Map - Allen iN 5.111E-6 3.521E-4 2.984E-3 1.373E-2 8 130
40 Lungmap Mouse e18.5 Epithelial (GSE52583) SubClass AT1 Top 500 Cluster 3 Mouse Lung E18.5 Epithelial AT1 c3 Lungmap Mouse Single Cell (Lungmap.net) 5.994E-6 4.027E-4 3.412E-3 1.611E-2 6 62
41 GSM777032 500 Stromal Cells, BEC.MLN, gp38- CD31+, Lymph Node, avg-5 Immgen.org, GSE15907 6.607E-6 4.243E-4 3.595E-3 1.775E-2 14 456
42 26Dn Top 500 Cluster 0 26Dn Top 500 Cluster 0 Brain Map - Allen iN 6.632E-6 4.243E-4 3.595E-3 1.782E-2 7 96
43 Facebase RNAseq e8.5 Floor Plate 1000 K4 FacebaseRNAseq e8.5 Floor Plate top-relative-expression-ranked 1000 k-means-cluster#4 FaceBase_RNAseq 1.457E-5 8.937E-4 7.573E-3 3.916E-2 10 248
44 26Dn SubClass 26Dn 2 Top 500 Cluster 0 26Dn SubClass 26Dn 2 Top 500 Cluster 0 Brain Map - Allen iN 1.463E-5 8.937E-4 7.573E-3 3.932E-2 8 150
45 Facebase RNAseq e9.5 Olfactory Placode 500 K4 FacebaseRNAseq e9.5 Olfactory Placode top-relative-expression-ranked 500 k-means-cluster#4 FaceBase_RNAseq 1.554E-5 9.279E-4 7.863E-3 4.176E-2 6 73
46 26Dp SubClass 26Dp 2 Top 500 All 26Dp SubClass 26Dp 2 Top 500 All Brain Map - Allen iN 1.698E-5 9.920E-4 8.406E-3 4.563E-2 14 496
47 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma 500 dev gonad e13.5 F VascAssocMesenchStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.954E-5 1.117E-3 9.464E-3
5.249E-2
 12 373
48 Lungmap Mouse e16.5 Matrix fibroblast SubClass Mature fibroblast 1 Top 500 All Mouse Lung E16.5 Mature fibroblast 1 top500 Lungmap Mouse Single Cell (Lungmap.net) 2.006E-5 1.123E-3 9.515E-3
5.390E-2
 12 374
49 PCBC ratio ESC vs iPSC method-OS-NL cfr-2X-p05 Pluripotent Stem Cells-reprogram NA vs Pluripotent Stem Cells-reprogram OS-NL-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 2.276E-5 1.248E-3 1.057E-2
6.114E-2
 6 78
50 54Dp SubClass 54Dp 2 Top 500 Cluster 3 54Dp SubClass 54Dp 2 Top 500 Cluster 3 Brain Map - Allen iN 2.429E-5 1.305E-3 1.106E-2
6.527E-2
 7 117
Show 45 more annotations

15: Computational [Display Chart] 474 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 306 Genes in module 306 MSigDb: C4 - CM: Cancer Modules 7.691E-10 3.646E-7 2.457E-6 3.646E-7 8 26
2 module 377 Genes in module 377 MSigDb: C4 - CM: Cancer Modules 5.170E-6 1.225E-3 8.258E-3 2.451E-3 4 10
3 module 423 Genes in module 423 MSigDb: C4 - CM: Cancer Modules 7.015E-5 9.208E-3
6.206E-2
 3.325E-2 3 7
4 module 478 Genes in module 478 MSigDb: C4 - CM: Cancer Modules 8.723E-5 9.208E-3
6.206E-2
 4.135E-2 4 19
5 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 9.713E-5 9.208E-3
6.206E-2
 4.604E-2 15 378
6 MORF EIF3S2 Neighborhood of EIF3S2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.409E-4 1.113E-2
7.502E-2
6.679E-2
 11 224
7 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 7.333E-4 4.009E-2
2.702E-1
3.476E-1
 13 361
8 module 110 Genes in module 110 MSigDb: C4 - CM: Cancer Modules 8.458E-4 4.009E-2
2.702E-1
4.009E-1
 3 15
9 module 160 Genes in module 160 MSigDb: C4 - CM: Cancer Modules 8.458E-4 4.009E-2
2.702E-1
4.009E-1
 3 15
10 module 133 Genes in module 133 MSigDb: C4 - CM: Cancer Modules 8.458E-4 4.009E-2
2.702E-1
4.009E-1
 3 15
11 module 35 Genes in module 35 MSigDb: C4 - CM: Cancer Modules 1.031E-3 4.423E-2
2.981E-1
4.888E-1
 3 16
12 GNF2 PTX3 Neighborhood of PTX3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.120E-3 4.423E-2
2.981E-1
5.307E-1
 4 36
Show 7 more annotations

16: MicroRNA [Display Chart] 1238 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-122:miRTarbase hsa-miR-122:miRTarbase miRTarbase 1.545E-7 1.913E-4 1.473E-3 1.913E-4 7 53
2 hsa-miR-155:miRTarbase hsa-miR-155:miRTarbase miRTarbase 1.147E-5 7.098E-3
5.465E-2
 1.420E-2 9 182
3 hsa-miR-136*:mirSVR highEffct hsa-miR-136*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.657E-5 1.922E-2
1.479E-1
5.765E-2
 8 168
4 hsa-miR-938:PITA hsa-miR-938:PITA TOP PITA 1.078E-4 3.208E-2
2.470E-1
1.335E-1
 6 98
5 hsa-miR-221:miRTarbase hsa-miR-221:miRTarbase miRTarbase 1.610E-4 3.208E-2
2.470E-1
1.994E-1
 4 36
6 hsa-miR-217:PITA hsa-miR-217:PITA TOP PITA 1.794E-4 3.208E-2
2.470E-1
2.221E-1
 10 319
7 hsa-miR-138:PITA hsa-miR-138:PITA TOP PITA 1.986E-4 3.208E-2
2.470E-1
2.459E-1
 9 263
8 hsa-miR-633:PITA hsa-miR-633:PITA TOP PITA 2.161E-4 3.208E-2
2.470E-1
2.675E-1
 9 266
9 ACACTCC,MIR-122A:MSigDB ACACTCC,MIR-122A:MSigDB MSigDB 2.438E-4 3.208E-2
2.470E-1
3.018E-1
 5 73
10 miR-122a:PicTar miR-122a:PicTar PicTar 2.591E-4 3.208E-2
2.470E-1
3.208E-1
 6 115
11 hsa-miR-122:TargetScan hsa-miR-122:TargetScan TargetScan 3.887E-4 4.056E-2
3.123E-1
4.812E-1
 6 124
12 hsa-miR-365:TargetScan hsa-miR-365:TargetScan TargetScan 3.932E-4 4.056E-2
3.123E-1
4.867E-1
 7 174
Show 7 more annotations

17: Drug [Display Chart] 21700 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 904 UP 5109870; Up 200; 25uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.430E-29 1.841E-25 1.944E-24 3.103E-25 27 166
2 3317 UP Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 1.696E-29 1.841E-25 1.944E-24 3.681E-25 27 167
3 5023 UP Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 5.437E-29 3.932E-25 4.154E-24 1.180E-24 27 174
4 573 UP deferoxamine mesylate salt; Up 200; 100uM; MCF7; HG-U133A Broad Institute CMAP 2.628E-28 1.426E-24 1.506E-23 5.702E-24 27 184
5 1276 DN Dequalinium dichloride [522-51-0]; Down 200; 7.6uM; HL60; HT HG-U133A Broad Institute CMAP 5.157E-26 1.978E-22 2.089E-21 1.119E-21 25 174
6 C016837 zinc chloride CTD 5.469E-26 1.978E-22 2.089E-21 1.187E-21 32 372
7 C004656 chloroacetaldehyde CTD 4.310E-21 1.194E-17 1.261E-16 9.352E-17 26 305
8 C025205 1,10-phenanthroline CTD 4.835E-21 1.194E-17 1.261E-16 1.049E-16 17 80
9 C452423 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine CTD 4.951E-21 1.194E-17 1.261E-16 1.074E-16 13 30
10 6677 UP Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; PC3; HT HG-U133A Broad Institute CMAP 1.001E-20 2.171E-17 2.293E-16 2.171E-16 21 167
11 1345 DN Betulinic acid [472-15-1]; Down 200; 8.8uM; HL60; HT HG-U133A Broad Institute CMAP 3.069E-20 6.055E-17 6.395E-16 6.660E-16 21 176
12 C000591541 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine CTD 3.748E-20 6.777E-17 7.158E-16 8.132E-16 13 34
13 D003676 Deferoxamine CTD 7.028E-20 1.173E-16 1.239E-15 1.525E-15 21 183
14 460 UP deferoxamine mesylate salt; Up 200; 100uM; PC3; HG-U133A Broad Institute CMAP 1.555E-19 2.410E-16 2.545E-15 3.374E-15 21 190
15 C437683 motexafin gadolinium CTD 4.492E-19 6.499E-16 6.864E-15 9.748E-15 19 147
16 2957 DN Pyrvinium pamoate [3546-41-6]; Down 200; 3.4uM; HL60; HT HG-U133A Broad Institute CMAP 1.202E-18 1.534E-15 1.620E-14 2.608E-14 20 181
17 1285 DN Ketoconazole [65277-42-1]; Down 200; 7.6uM; HL60; HT HG-U133A Broad Institute CMAP 1.202E-18 1.534E-15 1.620E-14 2.608E-14 20 181
18 D019345 Zinc Acetate CTD 3.714E-18 4.478E-15 4.730E-14 8.060E-14 19 164
19 C026305 cobalt sulfate CTD 5.253E-18 6.000E-15 6.337E-14 1.140E-13 12 35
20 584 UP dimethyloxalylglycine; Up 200; 1000uM; PC3; HG-U133A Broad Institute CMAP 9.239E-18 1.002E-14 1.059E-13 2.005E-13 19 172
21 2426 DN Progesterone [57-83-0]; Down 200; 12.8uM; HL60; HT HG-U133A Broad Institute CMAP 4.085E-17 4.221E-14 4.459E-13 8.865E-13 19 186
22 CID004634040 AC1NDZBW Stitch 4.521E-17 4.459E-14 4.710E-13 9.811E-13 19 187
23 C059262 cidofovir CTD 2.797E-16 2.639E-13 2.787E-12 6.069E-12 21 273
24 D003035 Cobalt CTD 3.489E-16 3.155E-13 3.332E-12 7.572E-12 21 276
25 D007069 Ifosfamide CTD 4.754E-16 4.127E-13 4.359E-12 1.032E-11 20 245
26 1755 DN Papaverine hydrochloride [61-25-6]; Down 200; 10.6uM; HL60; HG-U133A Broad Institute CMAP 8.242E-15 6.879E-12 7.266E-11 1.789E-10 17 181
27 CID000000718 fructose-1,6-diphosphate sodium salt Stitch 1.464E-13 1.176E-10 1.242E-9 3.176E-9 15 151
28 CID000001060 pyruvic acid Stitch 1.794E-13 1.390E-10 1.469E-9 3.893E-9 22 424
29 CID000099058 6-o-phosphonohexose Stitch 1.922E-13 1.438E-10 1.519E-9 4.171E-9 16 185
30 CID000000751 glyceraldehyde Stitch 8.949E-13 6.473E-10 6.837E-9 1.942E-8 14 140
31 C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) CTD 1.291E-12 9.034E-10 9.542E-9 2.800E-8 22 468
32 C025340 manganese chloride CTD 1.484E-12 9.987E-10 1.055E-8 3.220E-8 20 375
33 2480 DN Atovaquone [95233-18-4]; Down 200; 11uM; HL60; HT HG-U133A Broad Institute CMAP 1.519E-12 9.987E-10 1.055E-8 3.296E-8 15 177
34 D008687 Metformin CTD 2.770E-12 1.768E-9 1.867E-8 6.011E-8 20 388
35 C045037 testosterone-3-carboxymethyloxime-bovine serum albumin conjugate CTD 2.890E-12 1.774E-9 1.873E-8 6.272E-8 15 185
36 CID000000719 AC1Q6RZ4 Stitch 2.943E-12 1.774E-9 1.873E-8 6.386E-8 13 123
37 C060728 cobalt oxide CTD 3.247E-12 1.904E-9 2.011E-8 7.045E-8 10 54
38 C002802 tungsten carbide CTD 3.644E-12 2.081E-9 2.198E-8 7.907E-8 14 155
39 CID000003426 Laevuflex Stitch 6.430E-12 3.578E-9 3.779E-8 1.395E-7 17 272
40 CID000000603 allulose 6-phosphate Stitch 6.668E-12 3.617E-9 3.821E-8 1.447E-7 14 162
41 D004002 Clodronic Acid CTD 1.117E-11 5.914E-9 6.247E-8 2.425E-7 16 241
42 D007501 Iron CTD 1.713E-11 8.852E-9 9.349E-8 3.718E-7 19 380
43 CID000000724 3-phosphoglycerate Stitch 2.187E-11 1.088E-8 1.149E-7 4.745E-7 12 114
44 D007052 Ibuprofen CTD 2.206E-11 1.088E-8 1.149E-7 4.788E-7 17 294
45 D010938 Plant Oils CTD 3.108E-11 1.499E-8 1.583E-7 6.744E-7 21 496
46 2955 DN Rimexolone [49697-38-3]; Down 200; 10.8uM; HL60; HT HG-U133A Broad Institute CMAP 3.741E-11 1.765E-8 1.864E-7 8.118E-7 14 184
47 C512195 elesclomol CTD 4.411E-11 2.036E-8 2.151E-7 9.571E-7 9 49
48 D016566 Organoselenium Compounds CTD 5.670E-11 2.563E-8 2.708E-7 1.230E-6 10 71
49 D011899 Ranitidine CTD 6.538E-11 2.896E-8 3.058E-7 1.419E-6 12 125
50 D015125 Oxyquinoline CTD 2.110E-10 9.159E-8 9.674E-7 4.579E-6 15 250
Show 45 more annotations

18: Disease [Display Chart] 2265 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0334579 Anaplastic astrocytoma DisGeNET Curated 2.273E-9 5.149E-6 4.275E-5 5.149E-6 12 137
2 umls:C0007124 Noninfiltrating Intraductal Carcinoma DisGeNET Curated 1.415E-7 1.115E-4 9.259E-4 3.205E-4 14 281
3 umls:C0346957 Disseminated Malignant Neoplasm DisGeNET BeFree 1.523E-7 1.115E-4 9.259E-4 3.449E-4 11 162
4 umls:C1621958 Glioblastoma Multiforme DisGeNET BeFree 1.969E-7 1.115E-4 9.259E-4 4.461E-4 17 434
5 umls:C0862824 Lung cancer stage I DisGeNET BeFree 3.582E-7 1.519E-4 1.261E-3 8.112E-4 4 8
6 umls:C0206734 Hemangioblastoma DisGeNET Curated 4.023E-7 1.519E-4 1.261E-3 9.113E-4 6 34
7 umls:C0238461 Anaplastic thyroid carcinoma DisGeNET Curated 5.098E-7 1.650E-4 1.370E-3 1.155E-3 12 223
8 umls:C0854985 Adenocarcinoma of lung, stage I DisGeNET BeFree 8.003E-7 2.266E-4 1.881E-3 1.813E-3 5 21
9 umls:C0016057 Fibrosarcoma DisGeNET Curated 1.161E-6 2.922E-4 2.426E-3 2.629E-3 12 241
10 umls:C0022665 Kidney Neoplasm DisGeNET Curated 1.382E-6 3.129E-4 2.598E-3 3.129E-3 11 202
11 umls:C0042373 Vascular Diseases DisGeNET Curated 1.726E-6 3.554E-4 2.951E-3 3.910E-3 14 346
12 umls:C1337013 Differentiated Thyroid Gland Carcinoma DisGeNET BeFree 2.346E-6 4.427E-4 3.676E-3 5.313E-3 9 134
13 umls:C0017075 Ganglioneuroma DisGeNET BeFree 3.325E-6 5.724E-4 4.752E-3 7.532E-3 6 48
14 umls:C0002881 Anemia, Hemolytic, Congenital DisGeNET Curated 3.538E-6 5.724E-4 4.752E-3 8.013E-3 4 13
15 umls:C1134719 Invasive Ductal Breast Carcinoma DisGeNET Curated 4.471E-6 6.751E-4 5.605E-3 1.013E-2 11 228
16 umls:C0002882 Anemia, Hemolytic, Congenital Nonspherocytic DisGeNET Curated 6.161E-6 8.589E-4 7.131E-3 1.396E-2 3 5
17 umls:C1519670 Tumor Angiogenesis DisGeNET BeFree 6.447E-6 8.589E-4 7.131E-3 1.460E-2 15 443
18 umls:C0007115 Malignant neoplasm of thyroid DisGeNET BeFree 8.421E-6 1.060E-3 8.798E-3 1.907E-2 15 453
19 umls:C0022716 Menkes Kinky Hair Syndrome DisGeNET Curated 1.146E-5 1.325E-3 1.100E-2 2.597E-2 4 17
20 umls:C0153633 Malignant neoplasm of brain DisGeNET BeFree 1.170E-5 1.325E-3 1.100E-2 2.650E-2 8 124
21 umls:C0026640 Mouth Neoplasms DisGeNET Curated 1.247E-5 1.345E-3 1.116E-2 2.824E-2 6 60
22 umls:C0279702 Conventional (Clear Cell) Renal Cell Carcinoma DisGeNET Curated 1.718E-5 1.768E-3 1.468E-2 3.890E-2 13 367
23 umls:C0034069 Pulmonary Fibrosis DisGeNET Curated 1.912E-5 1.842E-3 1.529E-2 4.331E-2 12 317
24 umls:C0220650 Metastatic malignant neoplasm to brain DisGeNET BeFree 1.952E-5 1.842E-3 1.529E-2 4.421E-2 8 133
25 umls:C2973725 Pulmonary arterial hypertension DisGeNET BeFree 2.056E-5 1.863E-3 1.546E-2 4.656E-2 9 175
26 umls:C0149521 Pancreatitis, Chronic DisGeNET Curated 2.273E-5 1.980E-3 1.644E-2
5.149E-2
 11 271
27 umls:C0035078 Kidney Failure DisGeNET BeFree 2.445E-5 2.026E-3 1.682E-2
5.539E-2
 12 325
28 umls:C0024117 Chronic Obstructive Airway Disease DisGeNET Curated 2.504E-5 2.026E-3 1.682E-2
5.672E-2
 15 497
29 umls:C0278484 Malignant neoplasm of colon stage IV DisGeNET BeFree 2.802E-5 2.114E-3 1.755E-2
6.346E-2
 6 69
30 umls:C0007125 Carcinoma, Ehrlich Tumor DisGeNET BeFree 2.807E-5 2.114E-3 1.755E-2
6.358E-2
 4 21
31 umls:C0750979 Primary malignant neoplasm of brain DisGeNET BeFree 2.894E-5 2.114E-3 1.755E-2
6.554E-2
 5 42
32 umls:C0206718 Ganglioneuroblastoma DisGeNET BeFree 3.252E-5 2.302E-3 1.911E-2
7.365E-2
 5 43
33 umls:C0007621 Neoplastic Cell Transformation DisGeNET Curated 3.605E-5 2.474E-3 2.054E-2
8.166E-2
 7 106
34 umls:C3714844 Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia DisGeNET BeFree 3.772E-5 2.513E-3 2.086E-2
8.544E-2
 9 189
35 umls:C0338106 Adenocarcinoma of colon DisGeNET Curated 4.345E-5 2.812E-3 2.335E-2
9.841E-2
 10 240
36 umls:C0024221 Lymphangioma DisGeNET BeFree 5.046E-5 3.175E-3 2.636E-2
1.143E-1
 3 9
37 umls:C0042029 Urinary tract infection DisGeNET Curated 5.238E-5 3.206E-3 2.662E-2
1.186E-1
 6 77
38 umls:C0002878 Anemia, Hemolytic DisGeNET Curated 6.055E-5 3.557E-3 2.953E-2
1.371E-1
 6 79
39 umls:C0020542 Pulmonary Hypertension DisGeNET Curated 6.124E-5 3.557E-3 2.953E-2
1.387E-1
 10 250
40 umls:C0206062 Lung Diseases, Interstitial DisGeNET Curated 7.160E-5 3.966E-3 3.293E-2
1.622E-1
 7 118
41 umls:C0020312 Hydrothorax DisGeNET BeFree 7.355E-5 3.966E-3 3.293E-2
1.666E-1
 2 2
42 umls:C0334369 Comedocarcinoma, noninfiltrating DisGeNET BeFree 7.355E-5 3.966E-3 3.293E-2
1.666E-1
 2 2
43 umls:C0349566 Squamous cell carcinoma of tongue DisGeNET BeFree 7.964E-5 4.195E-3 3.483E-2
1.804E-1
 7 120
44 umls:C0264716 Chronic heart failure DisGeNET BeFree 8.548E-5 4.400E-3 3.654E-2
1.936E-1
 6 84
45 umls:C0005695 Bladder Neoplasm DisGeNET Curated 9.140E-5 4.600E-3 3.820E-2
2.070E-1
 11 316
46 umls:C0206682 Follicular thyroid carcinoma DisGeNET Curated 9.467E-5 4.661E-3 3.870E-2
2.144E-1
 8 166
47 umls:C0262655 Recurrent urinary tract infection DisGeNET BeFree 9.788E-5 4.717E-3 3.916E-2
2.217E-1
 3 11
48 umls:C1800706 Idiopathic Pulmonary Fibrosis DisGeNET Curated 1.110E-4 5.236E-3 4.347E-2
2.513E-1
 11 323
49 umls:C0243026 Sepsis DisGeNET Curated 1.181E-4 5.461E-3 4.534E-2
2.676E-1
 13 443
50 umls:C0740457 Malignant neoplasm of kidney DisGeNET BeFree 1.245E-4 5.639E-3 4.682E-2
2.819E-1
 12 385
Show 45 more annotations