Toppgene analysis for aggregated_1964_log, IC13, positive side

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1: GO: Molecular Function [Display Chart] 498 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding 3.858E-10 1.921E-7 1.304E-6 1.921E-7 19 365
2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding 8.497E-8 2.116E-5 1.436E-4 4.231E-5 16 358
3 GO:0001047 core promoter binding 1.923E-7 3.193E-5 2.168E-4 9.578E-5 11 165
4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding 3.954E-7 4.922E-5 3.342E-4 1.969E-4 13 259
5 GO:0001046 core promoter sequence-specific DNA binding 6.702E-7 6.676E-5 4.532E-4 3.338E-4 9 115
6 GO:0019207 kinase regulator activity 2.899E-6 2.406E-4 1.634E-3 1.444E-3 11 217
7 GO:0031625 ubiquitin protein ligase binding 4.454E-6 3.168E-4 2.151E-3 2.218E-3 12 273
8 GO:0044389 ubiquitin-like protein ligase binding 5.167E-6 3.216E-4 2.184E-3 2.573E-3 12 277
9 GO:0055131 C3HC4-type RING finger domain binding 1.229E-5 6.799E-4 4.616E-3 6.120E-3 3 6
10 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 2.199E-5 1.095E-3 7.435E-3 1.095E-2 6 66
11 GO:0051082 unfolded protein binding 3.049E-5 1.380E-3 9.372E-3 1.519E-2 7 103
12 GO:0019887 protein kinase regulator activity 5.147E-5 2.136E-3 1.450E-2 2.563E-2 9 196
13 GO:0002020 protease binding 6.903E-5 2.557E-3 1.736E-2 3.438E-2 7 117
14 GO:0008140 cAMP response element binding protein binding 7.188E-5 2.557E-3 1.736E-2 3.580E-2 3 10
15 GO:0004860 protein kinase inhibitor activity 1.195E-4 3.968E-3 2.694E-2
5.953E-2
 6 89
16 GO:0019210 kinase inhibitor activity 1.352E-4 4.208E-3 2.856E-2
6.732E-2
 6 91
17 GO:0004857 enzyme inhibitor activity 1.569E-4 4.597E-3 3.121E-2
7.815E-2
 12 393
18 GO:0000987 core promoter proximal region sequence-specific DNA binding 1.805E-4 4.955E-3 3.364E-2
8.990E-2
 12 399
19 GO:0001159 core promoter proximal region DNA binding 1.890E-4 4.955E-3 3.364E-2
9.414E-2
 12 401
20 GO:0004948 calcitonin receptor activity 2.197E-4 5.093E-3 3.458E-2
1.094E-1
 2 3
21 GO:0070888 E-box binding 2.250E-4 5.093E-3 3.458E-2
1.121E-1
 4 35
22 GO:0051059 NF-kappaB binding 2.250E-4 5.093E-3 3.458E-2
1.121E-1
 4 35
23 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2.514E-4 5.444E-3 3.696E-2
1.252E-1
 4 36
24 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding 4.638E-4 9.624E-3
6.534E-2
2.310E-1
 11 380
25 GO:0035259 glucocorticoid receptor binding 5.483E-4 1.092E-2
7.415E-2
2.731E-1
 3 19
26 GO:0051087 chaperone binding 7.109E-4 1.335E-2
9.066E-2
3.540E-1
 5 82
27 GO:0097642 calcitonin family receptor activity 7.241E-4 1.335E-2
9.066E-2
3.606E-1
 2 5
28 GO:0071889 14-3-3 protein binding 9.771E-4 1.701E-2
1.155E-1
4.866E-1
 3 23
29 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding 1.021E-3 1.701E-2
1.155E-1
5.085E-1
 7 182
30 GO:0003714 transcription corepressor activity 1.025E-3 1.701E-2
1.155E-1
5.104E-1
 8 236
31 GO:0031072 heat shock protein binding 2.239E-3 3.596E-2
2.442E-1
1.000E0
 5 106
32 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding 3.070E-3 4.778E-2
3.243E-1
1.000E0
 5 114
33 GO:0042826 histone deacetylase binding 3.188E-3 4.810E-2
3.266E-1
1.000E0
 5 115
Show 28 more annotations

2: GO: Biological Process [Display Chart] 3756 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001933 negative regulation of protein phosphorylation 4.298E-14 1.095E-10 9.648E-10 1.614E-10 25 427
2 GO:0042326 negative regulation of phosphorylation 5.832E-14 1.095E-10 9.648E-10 2.191E-10 26 474
3 GO:1901652 response to peptide 3.914E-12 4.900E-9 4.316E-8 1.470E-8 24 478
4 GO:0007623 circadian rhythm 5.823E-11 5.468E-8 4.816E-7 2.187E-7 16 214
5 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity 2.765E-10 2.077E-7 1.830E-6 1.039E-6 20 398
6 GO:0048511 rhythmic process 5.070E-10 3.174E-7 2.796E-6 1.904E-6 19 368
7 GO:1902532 negative regulation of intracellular signal transduction 1.984E-9 1.064E-6 9.375E-6 7.451E-6 21 494
8 GO:0009612 response to mechanical stimulus 2.269E-9 1.065E-6 9.385E-6 8.524E-6 15 236
9 GO:0051591 response to cAMP 2.758E-9 1.151E-6 1.014E-5 1.036E-5 11 109
10 GO:0051101 regulation of DNA binding 3.352E-9 1.259E-6 1.109E-5 1.259E-5 11 111
11 GO:0050684 regulation of mRNA processing 3.689E-9 1.260E-6 1.110E-5 1.386E-5 11 112
12 GO:0042542 response to hydrogen peroxide 5.474E-9 1.713E-6 1.509E-5 2.056E-5 12 146
13 GO:0006979 response to oxidative stress 9.599E-9 2.773E-6 2.443E-5 3.605E-5 19 440
14 GO:0043392 negative regulation of DNA binding 1.254E-8 3.217E-6 2.834E-5 4.712E-5 8 51
15 GO:0007568 aging 1.285E-8 3.217E-6 2.834E-5 4.826E-5 16 310
16 GO:0033673 negative regulation of kinase activity 1.797E-8 4.218E-6 3.715E-5 6.749E-5 15 275
17 GO:1903311 regulation of mRNA metabolic process 1.936E-8 4.278E-6 3.768E-5 7.272E-5 11 131
18 GO:0043409 negative regulation of MAPK cascade 2.493E-8 5.202E-6 4.582E-5 9.363E-5 12 167
19 GO:0014074 response to purine-containing compound 3.246E-8 6.372E-6 5.613E-5 1.219E-4 12 171
20 GO:0034599 cellular response to oxidative stress 3.393E-8 6.372E-6 5.613E-5 1.274E-4 14 247
21 GO:0006469 negative regulation of protein kinase activity 3.754E-8 6.714E-6 5.914E-5 1.410E-4 14 249
22 GO:0051098 regulation of binding 3.961E-8 6.763E-6 5.957E-5 1.488E-4 16 336
23 GO:0000302 response to reactive oxygen species 4.360E-8 7.121E-6 6.272E-5 1.638E-4 14 252
24 GO:2000677 regulation of transcription regulatory region DNA binding 5.710E-8 8.936E-6 7.871E-5 2.145E-4 7 41
25 GO:0046683 response to organophosphorus 5.972E-8 8.972E-6 7.903E-5 2.243E-4 11 146
26 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity 6.870E-8 9.718E-6 8.560E-5 2.580E-4 11 148
27 GO:0070373 negative regulation of ERK1 and ERK2 cascade 6.986E-8 9.718E-6 8.560E-5 2.624E-4 8 63
28 GO:0051100 negative regulation of binding 7.886E-8 1.058E-5 9.318E-5 2.962E-4 11 150
29 GO:0031124 mRNA 3'-end processing 1.049E-7 1.359E-5 1.197E-4 3.940E-4 9 92
30 GO:0001525 angiogenesis 1.257E-7 1.574E-5 1.386E-4 4.721E-4 18 465
31 GO:0060537 muscle tissue development 1.480E-7 1.793E-5 1.579E-4 5.558E-4 17 419
32 GO:0043620 regulation of DNA-templated transcription in response to stress 1.618E-7 1.899E-5 1.672E-4 6.076E-4 8 70
33 GO:0048660 regulation of smooth muscle cell proliferation 1.999E-7 2.276E-5 2.005E-4 7.510E-4 10 130
34 GO:0048659 smooth muscle cell proliferation 2.657E-7 2.935E-5 2.585E-4 9.979E-4 10 134
35 GO:0071496 cellular response to external stimulus 2.792E-7 2.996E-5 2.639E-4 1.049E-3 14 293
36 GO:1901653 cellular response to peptide 2.987E-7 3.034E-5 2.672E-4 1.122E-3 15 341
37 GO:0042594 response to starvation 2.988E-7 3.034E-5 2.672E-4 1.122E-3 11 171
38 GO:0043434 response to peptide hormone 3.248E-7 3.210E-5 2.828E-4 1.220E-3 17 443
39 GO:0014745 negative regulation of muscle adaptation 3.723E-7 3.585E-5 3.158E-4 1.398E-3 4 8
40 GO:0097305 response to alcohol 3.970E-7 3.728E-5 3.284E-4 1.491E-3 16 398
41 GO:2000678 negative regulation of transcription regulatory region DNA binding 4.875E-7 4.466E-5 3.934E-4 1.831E-3 5 19
42 GO:0043484 regulation of RNA splicing 5.302E-7 4.741E-5 4.176E-4 1.991E-3 9 111
43 GO:0071409 cellular response to cycloheximide 6.415E-7 5.510E-5 4.853E-4 2.409E-3 3 3
44 GO:0036499 PERK-mediated unfolded protein response 6.455E-7 5.510E-5 4.853E-4 2.424E-3 5 20
45 GO:0050685 positive regulation of mRNA processing 7.243E-7 6.045E-5 5.325E-4 2.720E-3 6 37
46 GO:0033002 muscle cell proliferation 7.699E-7 6.286E-5 5.537E-4 2.892E-3 11 188
47 GO:0007519 skeletal muscle tissue development 9.481E-7 7.576E-5 6.674E-4 3.561E-3 11 192
48 GO:0009314 response to radiation 1.016E-6 7.869E-5 6.932E-4 3.818E-3 17 481
49 GO:0031123 RNA 3'-end processing 1.027E-6 7.869E-5 6.932E-4 3.856E-3 9 120
50 GO:0032677 regulation of interleukin-8 production 1.072E-6 8.054E-5 7.095E-4 4.027E-3 7 62
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 284 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1990622 CHOP-ATF3 complex 7.184E-5 1.101E-2
6.855E-2
 2.040E-2 2 2
2 GO:0005667 transcription factor complex 7.751E-5 1.101E-2
6.855E-2
 2.201E-2 12 369
3 GO:0000791 euchromatin 3.625E-4 3.432E-2
2.137E-1
1.030E-1
 4 40

4: Human Phenotype [Display Chart] 417 annotations before applied cutoff / 4410 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 3151 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0005334 abnormal fat pad morphology 2.822E-6 7.561E-3
6.527E-2
 8.892E-3 16 285
2 MP:0002145 abnormal T cell differentiation 9.282E-6 7.561E-3
6.527E-2
 2.925E-2 19 426
3 MP:0008271 abnormal bone ossification 9.923E-6 7.561E-3
6.527E-2
 3.127E-2 19 428
4 MP:0000715 decreased thymocyte number 1.135E-5 7.561E-3
6.527E-2
 3.577E-2 12 183
5 MP:0008752 abnormal tumor necrosis factor level 1.200E-5 7.561E-3
6.527E-2
 3.780E-2 12 184
6 MP:0000010 abnormal abdominal fat pad morphology 3.129E-5 1.026E-2
8.860E-2
9.859E-2
 13 236
7 MP:0008552 abnormal circulating tumor necrosis factor level 3.220E-5 1.026E-2
8.860E-2
1.015E-1
 10 141
8 MP:0004809 increased hematopoietic stem cell number 3.295E-5 1.026E-2
8.860E-2
1.038E-1
 7 64
9 MP:0003424 premature neuronal precursor differentiation 3.480E-5 1.026E-2
8.860E-2
1.096E-1
 5 27
10 MP:0003418 premature intramembranous bone ossification 3.583E-5 1.026E-2
8.860E-2
1.129E-1
 4 14
11 MP:0000081 premature suture closure 3.583E-5 1.026E-2
8.860E-2
1.129E-1
 4 14
12 MP:0001650 abnormal seizure response to electrical stimulation 5.003E-5 1.314E-2
1.134E-1
1.576E-1
 5 29
13 MP:0008553 increased circulating tumor necrosis factor level 5.622E-5 1.359E-2
1.174E-1
1.771E-1
 8 94
14 MP:0004796 increased anti-histone antibody level 6.371E-5 1.359E-2
1.174E-1
2.007E-1
 4 16
15 MP:0005595 abnormal vascular smooth muscle physiology 6.471E-5 1.359E-2
1.174E-1
2.039E-1
 10 153
16 MP:0003725 increased autoantibody level 8.044E-5 1.519E-2
1.311E-1
2.535E-1
 10 157
17 MP:0005591 decreased vasodilation 8.196E-5 1.519E-2
1.311E-1
2.583E-1
 5 32
18 MP:0004808 abnormal hematopoietic stem cell morphology 9.427E-5 1.650E-2
1.425E-1
2.971E-1
 10 160
19 MP:0020175 abnormal IgG1 level 1.033E-4 1.713E-2
1.479E-1
3.255E-1
 12 229
20 MP:0005092 decreased double-positive T cell number 1.157E-4 1.745E-2
1.507E-1
3.646E-1
 11 197
21 MP:0000858 altered metastatic potential 1.163E-4 1.745E-2
1.507E-1
3.665E-1
 9 133
22 MP:0002658 abnormal liver regeneration 1.277E-4 1.827E-2
1.577E-1
4.023E-1
 5 35
23 MP:0005023 abnormal wound healing 1.383E-4 1.827E-2
1.577E-1
4.358E-1
 11 201
24 MP:0003658 abnormal capillary morphology 1.409E-4 1.827E-2
1.577E-1
4.441E-1
 8 107
25 MP:0002408 abnormal double-positive T cell morphology 1.487E-4 1.827E-2
1.577E-1
4.687E-1
 12 238
26 MP:0000107 abnormal frontal bone morphology 1.508E-4 1.827E-2
1.577E-1
4.751E-1
 7 81
27 MP:0006319 abnormal epididymal fat pad morphology 1.604E-4 1.872E-2
1.616E-1
5.054E-1
 8 109
28 MP:0008273 abnormal intramembranous bone ossification 1.850E-4 1.967E-2
1.698E-1
5.830E-1
 6 59
29 MP:0001273 decreased metastatic potential 1.850E-4 1.967E-2
1.698E-1
5.830E-1
 6 59
30 MP:0008568 abnormal interleukin secretion 1.873E-4 1.967E-2
1.698E-1
5.900E-1
 18 487
31 MP:0000702 enlarged lymph nodes 2.119E-4 2.154E-2
1.859E-1
6.676E-1
 11 211
32 MP:0000249 abnormal blood vessel physiology 2.382E-4 2.304E-2
1.989E-1
7.506E-1
 16 410
33 MP:0002364 abnormal thymus size 2.449E-4 2.304E-2
1.989E-1
7.715E-1
 16 411
34 MP:0004947 skin inflammation 2.486E-4 2.304E-2
1.989E-1
7.833E-1
 9 147
35 MP:0004200 decreased fetal size 2.596E-4 2.338E-2
2.018E-1
8.182E-1
 11 216
36 MP:0008961 abnormal basal metabolism 3.088E-4 2.676E-2
2.310E-1
9.729E-1
 5 42
37 MP:0001340 abnormal eyelid morphology 3.143E-4 2.676E-2
2.310E-1
9.902E-1
 12 258
38 MP:0004198 abnormal fetal size 3.687E-4 3.057E-2
2.639E-1
1.000E0
 11 225
39 MP:0003416 premature bone ossification 4.007E-4 3.078E-2
2.657E-1
1.000E0
 4 25
40 MP:0001601 abnormal myelopoiesis 4.052E-4 3.078E-2
2.657E-1
1.000E0
 9 157
41 MP:0008499 increased IgG1 level 4.328E-4 3.078E-2
2.657E-1
1.000E0
 7 96
42 MP:0003213 decreased susceptibility to age related obesity 4.340E-4 3.078E-2
2.657E-1
1.000E0
 3 11
43 MP:0009895 decreased palatine bone horizontal plate size 4.340E-4 3.078E-2
2.657E-1
1.000E0
 3 11
44 MP:0002339 abnormal lymph node morphology 4.395E-4 3.078E-2
2.657E-1
1.000E0
 15 390
45 MP:0005501 abnormal skin physiology 4.395E-4 3.078E-2
2.657E-1
1.000E0
 14 348
46 MP:0003814 vascular smooth muscle hypoplasia 4.684E-4 3.208E-2
2.770E-1
1.000E0
 4 26
47 MP:0000701 abnormal lymph node size 4.904E-4 3.288E-2
2.838E-1
1.000E0
 12 271
48 MP:0004794 increased anti-nuclear antigen antibody level 5.069E-4 3.328E-2
2.873E-1
1.000E0
 8 129
49 MP:0002450 abnormal lymph organ development 5.438E-4 3.497E-2
3.019E-1
1.000E0
 4 27
50 MP:0005249 abnormal palatine bone morphology 5.803E-4 3.594E-2
3.102E-1
1.000E0
 5 48
Show 45 more annotations

6: Domain [Display Chart] 958 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00338 BRLZ SMART 6.452E-10 2.201E-7 1.638E-6 6.181E-7 9 52
2 PS00036 BZIP BASIC PROSITE 7.714E-10 2.201E-7 1.638E-6 7.390E-7 9 53
3 PS50217 BZIP PROSITE 7.714E-10 2.201E-7 1.638E-6 7.390E-7 9 53
4 IPR004827 bZIP InterPro 9.188E-10 2.201E-7 1.638E-6 8.802E-7 9 54
5 PF00170 bZIP 1 Pfam 1.527E-8 2.927E-6 2.178E-5 1.463E-5 7 34
6 IPR008917 TF DNA-bd InterPro 2.859E-8 4.566E-6 3.398E-5 2.739E-5 7 37
7 PF07716 bZIP 2 Pfam 2.748E-7 3.761E-5 2.799E-4 2.633E-4 5 17
8 PF03957 Jun Pfam 6.587E-7 4.854E-5 3.612E-4 6.310E-4 3 3
9 PF11928 DUF3446 Pfam 6.587E-7 4.854E-5 3.612E-4 6.310E-4 3 3
10 IPR003070 Nuc orph rcpt InterPro 6.587E-7 4.854E-5 3.612E-4 6.310E-4 3 3
11 IPR021849 DUF3446 InterPro 6.587E-7 4.854E-5 3.612E-4 6.310E-4 3 3
12 IPR005643 JNK InterPro 6.587E-7 4.854E-5 3.612E-4 6.310E-4 3 3
13 IPR002112 Leuzip Jun InterPro 6.587E-7 4.854E-5 3.612E-4 6.310E-4 3 3
14 IPR026052 DNA-bd prot-inh InterPro 2.618E-6 1.791E-4 1.333E-3 2.508E-3 3 4
15 IPR002087 Anti prolifrtn InterPro 1.292E-5 6.514E-4 4.848E-3 1.238E-2 3 6
16 PS01203 BTG 2 PROSITE 1.292E-5 6.514E-4 4.848E-3 1.238E-2 3 6
17 PF07742 BTG Pfam 1.292E-5 6.514E-4 4.848E-3 1.238E-2 3 6
18 SM00099 btg1 SMART 1.292E-5 6.514E-4 4.848E-3 1.238E-2 3 6
19 PS00960 BTG 1 PROSITE 1.292E-5 6.514E-4 4.848E-3 1.238E-2 3 6
20 4.10.280.10 - Gene3D 4.884E-5 2.124E-3 1.581E-2 4.679E-2 7 109
21 PF01556 DnaJ C Pfam 5.322E-5 2.124E-3 1.581E-2
5.099E-2
 3 9
22 IPR008971 HSP40/DnaJ pept-bd InterPro 5.322E-5 2.124E-3 1.581E-2
5.099E-2
 3 9
23 IPR000837 AP-1 InterPro 5.322E-5 2.124E-3 1.581E-2
5.099E-2
 3 9
24 IPR002939 DnaJ C InterPro 5.322E-5 2.124E-3 1.581E-2
5.099E-2
 3 9
25 PF00010 HLH Pfam 5.809E-5 2.226E-3 1.657E-2
5.565E-2
 7 112
26 IPR019523 Prot Pase1 reg-su15A/B C InterPro 7.616E-5 2.533E-3 1.885E-2
7.296E-2
 2 2
27 IPR026780 PNRC1/2 InterPro 7.616E-5 2.533E-3 1.885E-2
7.296E-2
 2 2
28 PF10488 PP1c bdg Pfam 7.616E-5 2.533E-3 1.885E-2
7.296E-2
 2 2
29 SM00353 HLH SMART 7.667E-5 2.533E-3 1.885E-2
7.345E-2
 7 117
30 PS50888 BHLH PROSITE 8.092E-5 2.584E-3 1.923E-2
7.752E-2
 7 118
31 IPR011598 bHLH dom InterPro 8.535E-5 2.638E-3 1.963E-2
8.176E-2
 7 119
32 IPR024824 GADD45 InterPro 2.272E-4 6.801E-3
5.062E-2
2.176E-1
 2 3
33 1.10.880.10 - Gene3D 3.392E-4 9.557E-3
7.113E-2
3.249E-1
 3 16
34 PF00012 HSP70 Pfam 3.392E-4 9.557E-3
7.113E-2
3.249E-1
 3 16
35 PS01036 HSP70 3 PROSITE 4.092E-4 1.056E-2
7.856E-2
3.920E-1
 3 17
36 PS00297 HSP70 1 PROSITE 4.092E-4 1.056E-2
7.856E-2
3.920E-1
 3 17
37 PS00329 HSP70 2 PROSITE 4.092E-4 1.056E-2
7.856E-2
3.920E-1
 3 17
38 PD007152 TSC-22 Dip Bun ProDom 4.517E-4 1.056E-2
7.856E-2
4.328E-1
 2 4
39 IPR000580 TSC-22 Dip Bun InterPro 4.517E-4 1.056E-2
7.856E-2
4.328E-1
 2 4
40 PF01166 TSC22 Pfam 4.517E-4 1.056E-2
7.856E-2
4.328E-1
 2 4
41 PS01289 TSC22 PROSITE 4.517E-4 1.056E-2
7.856E-2
4.328E-1
 2 4
42 IPR013126 Hsp 70 fam InterPro 4.879E-4 1.113E-2
8.283E-2
4.674E-1
 3 18
43 IPR018253 DnaJ domain CS InterPro 1.651E-3 3.678E-2
2.737E-1
1.000E0
 3 27
44 PF00619 CARD Pfam 1.837E-3 4.000E-2
2.977E-1
1.000E0
 3 28
45 IPR015429 Cyclin L/T InterPro 2.060E-3 4.385E-2
3.264E-1
1.000E0
 2 8
Show 40 more annotations

7: Pathway [Display Chart] 957 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 138006 ATF-2 transcription factor network BioSystems: Pathway Interaction Database 1.177E-11 1.126E-8 8.380E-8 1.126E-8 11 55
2 711361 Oncostatin M Signaling Pathway BioSystems: WikiPathways 1.170E-9 5.597E-7 4.165E-6 1.119E-6 10 63
3 137932 IL6-mediated signaling events BioSystems: Pathway Interaction Database 1.552E-8 4.421E-6 3.290E-5 1.485E-5 8 43
4 198832 Adipogenesis BioSystems: WikiPathways 1.848E-8 4.421E-6 3.290E-5 1.768E-5 12 133
5 198779 MAPK signaling pathway BioSystems: WikiPathways 2.536E-8 4.854E-6 3.612E-5 2.427E-5 13 166
6 137939 Direct p53 effectors BioSystems: Pathway Interaction Database 1.978E-7 3.155E-5 2.348E-4 1.893E-4 11 134
7 739007 Spinal Cord Injury BioSystems: WikiPathways 3.325E-7 4.546E-5 3.383E-4 3.182E-4 10 112
8 P00006 Apoptosis signaling pathway PantherDB 1.463E-6 1.750E-4 1.302E-3 1.400E-3 9 102
9 198828 Hypertrophy Model BioSystems: WikiPathways 1.846E-6 1.963E-4 1.461E-3 1.767E-3 5 20
10 198782 EGFR1 Signaling Pathway BioSystems: WikiPathways 3.178E-6 3.041E-4 2.263E-3 3.041E-3 11 177
11 83048 MAPK signaling pathway BioSystems: KEGG 4.236E-6 3.685E-4 2.742E-3 4.053E-3 13 259
12 373901 HTLV-I infection BioSystems: KEGG 5.009E-6 3.995E-4 2.973E-3 4.794E-3 13 263
13 M17941 Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells MSigDB C2 BIOCARTA (v5.1) 9.049E-6 6.661E-4 4.957E-3 8.659E-3 5 27
14 137993 Calcineurin-regulated NFAT-dependent transcription in lymphocytes BioSystems: Pathway Interaction Database 1.190E-5 8.133E-4 6.052E-3 1.139E-2 6 48
15 138057 ErbB1 downstream signaling BioSystems: Pathway Interaction Database 1.485E-5 8.780E-4 6.534E-3 1.421E-2 8 103
16 138061 CD40/CD40L signaling BioSystems: Pathway Interaction Database 1.556E-5 8.780E-4 6.534E-3 1.490E-2 5 30
17 672462 Prolactin Signaling Pathway BioSystems: WikiPathways 1.560E-5 8.780E-4 6.534E-3 1.493E-2 7 75
18 137976 IL2-mediated signaling events BioSystems: Pathway Interaction Database 1.906E-5 1.013E-3 7.540E-3 1.824E-2 6 52
19 137963 Regulation of nuclear SMAD2/3 signaling BioSystems: Pathway Interaction Database 2.021E-5 1.018E-3 7.576E-3 1.934E-2 7 78
20 M4388 Cadmium induces DNA synthesis and proliferation in macrophages MSigDB C2 BIOCARTA (v5.1) 2.136E-5 1.022E-3 7.606E-3 2.044E-2 4 16
21 523016 Transcriptional misregulation in cancer BioSystems: KEGG 2.309E-5 1.052E-3 7.832E-3 2.210E-2 10 179
22 694606 Hepatitis B BioSystems: KEGG 2.775E-5 1.207E-3 8.982E-3 2.655E-2 9 146
23 169349 Validated transcriptional targets of AP1 family members Fra1 and Fra2 BioSystems: Pathway Interaction Database 2.936E-5 1.222E-3 9.091E-3 2.810E-2 5 34
24 711360 Integrated Pancreatic Cancer Pathway BioSystems: WikiPathways 4.601E-5 1.835E-3 1.365E-2 4.403E-2 10 194
25 920957 Corticotropin-releasing hormone BioSystems: WikiPathways 5.138E-5 1.940E-3 1.444E-2 4.917E-2 7 90
26 169353 Validated targets of C-MYC transcriptional repression BioSystems: Pathway Interaction Database 5.270E-5 1.940E-3 1.444E-2
5.044E-2
 6 62
27 M10628 ATM Signaling Pathway MSigDB C2 BIOCARTA (v5.1) 5.499E-5 1.949E-3 1.450E-2
5.263E-2
 4 20
28 138045 HIF-1-alpha transcription factor network BioSystems: Pathway Interaction Database 6.897E-5 2.357E-3 1.754E-2
6.601E-2
 6 65
29 198885 IL-2 Signaling pathway BioSystems: WikiPathways 8.378E-5 2.669E-3 1.986E-2
8.018E-2
 5 42
30 193147 Osteoclast differentiation BioSystems: KEGG 8.867E-5 2.669E-3 1.986E-2
8.486E-2
 8 132
31 M7897 Inhibition of Cellular Proliferation by Gleevec MSigDB C2 BIOCARTA (v5.1) 9.802E-5 2.669E-3 1.986E-2
9.381E-2
 4 23
32 906025 Loss of Function of TGFBR1 in Cancer BioSystems: REACTOME 1.227E-4 2.669E-3 1.986E-2
1.174E-1
 6 72
33 906017 Loss of Function of SMAD4 in Cancer BioSystems: REACTOME 1.227E-4 2.669E-3 1.986E-2
1.174E-1
 6 72
34 906016 Signaling by TGF-beta Receptor Complex in Cancer BioSystems: REACTOME 1.227E-4 2.669E-3 1.986E-2
1.174E-1
 6 72
35 106504 Signaling by TGF-beta Receptor Complex BioSystems: REACTOME 1.227E-4 2.669E-3 1.986E-2
1.174E-1
 6 72
36 906026 TGFBR1 LBD Mutants in Cancer BioSystems: REACTOME 1.227E-4 2.669E-3 1.986E-2
1.174E-1
 6 72
37 906018 SMAD4 MH2 Domain Mutants in Cancer BioSystems: REACTOME 1.227E-4 2.669E-3 1.986E-2
1.174E-1
 6 72
38 906020 SMAD2/3 Phosphorylation Motif Mutants in Cancer BioSystems: REACTOME 1.227E-4 2.669E-3 1.986E-2
1.174E-1
 6 72
39 906022 Loss of Function of TGFBR2 in Cancer BioSystems: REACTOME 1.227E-4 2.669E-3 1.986E-2
1.174E-1
 6 72
40 906021 SMAD2/3 MH2 Domain Mutants in Cancer BioSystems: REACTOME 1.227E-4 2.669E-3 1.986E-2
1.174E-1
 6 72
41 906027 TGFBR1 KD Mutants in Cancer BioSystems: REACTOME 1.227E-4 2.669E-3 1.986E-2
1.174E-1
 6 72
42 906019 Loss of Function of SMAD2/3 in Cancer BioSystems: REACTOME 1.227E-4 2.669E-3 1.986E-2
1.174E-1
 6 72
43 906024 TGFBR2 Kinase Domain Mutants in Cancer BioSystems: REACTOME 1.227E-4 2.669E-3 1.986E-2
1.174E-1
 6 72
44 906023 TGFBR2 MSI Frameshift Mutants in Cancer BioSystems: REACTOME 1.227E-4 2.669E-3 1.986E-2
1.174E-1
 6 72
45 P00046 Oxidative stress response PantherDB 1.304E-4 2.774E-3 2.064E-2
1.248E-1
 5 46
46 198813 Diurnally regulated genes with circadian orthologs BioSystems: WikiPathways 1.948E-4 3.988E-3 2.968E-2
1.864E-1
 5 50
47 377873 Herpes simplex infection BioSystems: KEGG 1.959E-4 3.988E-3 2.968E-2
1.875E-1
 9 188
48 169352 Regulation of Wnt-mediated beta catenin signaling and target gene transcription BioSystems: Pathway Interaction Database 2.053E-4 4.093E-3 3.046E-2
1.965E-1
 6 79
49 83064 TGF-beta signaling pathway BioSystems: KEGG 2.200E-4 4.297E-3 3.197E-2
2.105E-1
 6 80
50 198871 Id Signaling Pathway BioSystems: WikiPathways 2.349E-4 4.495E-3 3.345E-2
2.248E-1
 5 52
Show 45 more annotations

8: Pubmed [Display Chart] 40825 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20628624:gr Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". GeneRIF 1.375E-20 2.808E-16 3.143E-15 5.615E-16 17 172
2 20628624 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". Pubmed 1.375E-20 2.808E-16 3.143E-15 5.615E-16 17 172
3 19453261:gr High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. GeneRIF 1.678E-18 1.712E-14 1.917E-13 6.850E-14 20 383
4 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 1.678E-18 1.712E-14 1.917E-13 6.850E-14 20 383
5 24952347 DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NF¿B complex in the (de-)methylation of TRAF1. Pubmed 9.082E-16 7.415E-12 8.301E-11 3.708E-11 11 74
6 17495958 Biphasic regulation of AP-1 subunits during human epidermal wound healing. Pubmed 3.165E-13 1.846E-9 2.066E-8 1.292E-8 5 5
7 17495958:gr Biphasic regulation of AP-1 subunits during human epidermal wound healing. GeneRIF 3.165E-13 1.846E-9 2.066E-8 1.292E-8 5 5
8 20398657 The steroid receptor RNA activator protein is recruited to promoter regions and acts as a transcriptional repressor. Pubmed 7.477E-12 3.816E-8 4.271E-7 3.053E-7 7 31
9 20102225 Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays. Pubmed 9.545E-12 4.330E-8 4.847E-7 3.897E-7 7 32
10 21937452 Binding site specificity and factor redundancy in activator protein-1-driven human papillomavirus chromatin-dependent transcription. Pubmed 1.759E-11 7.179E-8 8.037E-7 7.179E-7 5 8
11 20195357 A comprehensive resource of interacting protein regions for refining human transcription factor networks. Pubmed 3.064E-11 1.137E-7 1.273E-6 1.251E-6 11 188
12 25613138 HIV-1 subtypes B and C Tat differentially impact synaptic plasticity expression and implicates HIV-associated neurocognitive disorders. Pubmed 3.522E-11 1.198E-7 1.341E-6 1.438E-6 7 38
13 17681951:gr Heterodimerization with Jun family members regulates c-Fos nucleocytoplasmic traffic. GeneRIF 1.013E-10 2.675E-7 2.994E-6 4.135E-6 4 4
14 14525795 Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1. Pubmed 1.013E-10 2.675E-7 2.994E-6 4.135E-6 4 4
15 14525795:gr Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1. GeneRIF 1.013E-10 2.675E-7 2.994E-6 4.135E-6 4 4
16 22094256 A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Pubmed 1.048E-10 2.675E-7 2.994E-6 4.279E-6 8 73
17 26735018 An ID2-dependent mechanism for VHL inactivation in cancer. Pubmed 2.146E-10 5.153E-7 5.769E-6 8.761E-6 6 26
18 15507668 Constitutive expression of the AP-1 transcription factors c-jun, junD, junB, and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma. Pubmed 5.052E-10 1.031E-6 1.154E-5 2.062E-5 4 5
19 1702972 A set of human putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes. Pubmed 5.052E-10 1.031E-6 1.154E-5 2.062E-5 4 5
20 15507668:gr Constitutive expression of the AP-1 transcription factors c-jun, junD, junB, and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma. GeneRIF 5.052E-10 1.031E-6 1.154E-5 2.062E-5 4 5
21 20936779 A human MAP kinase interactome. Pubmed 7.221E-10 1.404E-6 1.572E-5 2.948E-5 14 486
22 24029232 Protein kinase C ¿ is a central signaling node and therapeutic target for breast cancer stem cells. Pubmed 1.512E-9 2.469E-6 2.764E-5 6.172E-5 4 6
23 8570175 B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. Pubmed 1.512E-9 2.469E-6 2.764E-5 6.172E-5 4 6
24 9872330 Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. Pubmed 1.512E-9 2.469E-6 2.764E-5 6.172E-5 4 6
25 10523647 CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. Pubmed 1.512E-9 2.469E-6 2.764E-5 6.172E-5 4 6
26 23661758 Networks of bZIP protein-protein interactions diversified over a billion years of evolution. Pubmed 2.105E-9 3.305E-6 3.699E-5 8.592E-5 6 37
27 25241761 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. Pubmed 3.417E-9 4.830E-6 5.406E-5 1.395E-4 12 371
28 11756408 Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. Pubmed 3.519E-9 4.830E-6 5.406E-5 1.437E-4 4 7
29 10220381 Smads bind directly to the Jun family of AP-1 transcription factors. Pubmed 3.519E-9 4.830E-6 5.406E-5 1.437E-4 4 7
30 24551192 The expression of HIV-1 Vpu in monocytes causes increased secretion of TGF-Ã? that activates profibrogenic genes in hepatic stellate cells. Pubmed 3.549E-9 4.830E-6 5.406E-5 1.449E-4 5 19
31 24162774 The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-Ã?1 production and FcRL4 expression. Pubmed 5.399E-9 7.110E-6 7.960E-5 2.204E-4 8 119
32 26641092 The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells. Pubmed 6.350E-9 8.101E-6 9.069E-5 2.592E-4 10 239
33 26747248 CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas. Pubmed 7.020E-9 8.429E-6 9.436E-5 2.866E-4 4 8
34 17681951 Heterodimerization with Jun family members regulates c-Fos nucleocytoplasmic traffic. Pubmed 7.020E-9 8.429E-6 9.436E-5 2.866E-4 4 8
35 21231916 The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. Pubmed 1.016E-8 1.153E-5 1.290E-4 4.150E-4 5 23
36 12805554 Comprehensive identification of human bZIP interactions with coiled-coil arrays. Pubmed 1.016E-8 1.153E-5 1.290E-4 4.150E-4 5 23
37 24318877 Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. Pubmed 1.260E-8 1.354E-5 1.516E-4 5.146E-4 4 9
38 21763498 Reciprocal regulation of human immunodeficiency virus-1 gene expression and replication by heat shock proteins 40 and 70. Pubmed 1.260E-8 1.354E-5 1.516E-4 5.146E-4 4 9
39 18950845:gr Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. GeneRIF 1.549E-8 1.622E-5 1.815E-4 6.324E-4 7 88
40 18950845 Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. Pubmed 1.677E-8 1.624E-5 1.818E-4 6.846E-4 7 89
41 23921388 Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. Pubmed 2.095E-8 1.624E-5 1.818E-4 8.555E-4 4 10
42 18814951:gr Gene-expression profiles of peripheral blood mononuclear cell subpopulations in acute graft-vs-host disease following cord blood transplantation. GeneRIF 2.095E-8 1.624E-5 1.818E-4 8.555E-4 4 10
43 18814951 Gene-expression profiles of peripheral blood mononuclear cell subpopulations in acute graft-vs-host disease following cord blood transplantation. Pubmed 2.095E-8 1.624E-5 1.818E-4 8.555E-4 4 10
44 12168790 GADD153 is an independent prognostic factor in melanoma: immunohistochemical and molecular genetic analysis. Pubmed 3.222E-8 1.624E-5 1.818E-4 1.315E-3 3 3
45 23614275 Influence of genistein on c-Jun, c-Fos and Fos-B of AP-1 subunits expression in skin keratinocytes, fibroblasts and keloid fibroblasts cultured in vitro. Pubmed 3.222E-8 1.624E-5 1.818E-4 1.315E-3 3 3
46 23334790:gr Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis. GeneRIF 3.222E-8 1.624E-5 1.818E-4 1.315E-3 3 3
47 15645115 Expression of Id proteins in human hepatocellular carcinoma: relevance to tumor dedifferentiation. Pubmed 3.222E-8 1.624E-5 1.818E-4 1.315E-3 3 3
48 15645115:gr Expression of Id proteins in human hepatocellular carcinoma: relevance to tumor dedifferentiation. GeneRIF 3.222E-8 1.624E-5 1.818E-4 1.315E-3 3 3
49 8622660 Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10. Pubmed 3.222E-8 1.624E-5 1.818E-4 1.315E-3 3 3
50 22698403:gr ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21. GeneRIF 3.222E-8 1.624E-5 1.818E-4 1.315E-3 3 3
Show 45 more annotations

9: Interaction [Display Chart] 4211 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:DNMT3L DNMT3L interactions 7.375E-10 1.660E-6 1.482E-5 3.106E-6 11 86
2 int:BATF BATF interactions 7.886E-10 1.660E-6 1.482E-5 3.321E-6 7 21
3 int:MYOD1 MYOD1 interactions 3.407E-9 4.782E-6 4.267E-5 1.435E-5 11 99
4 int:HSPA1A HSPA1A interactions 1.974E-8 2.078E-5 1.855E-4 8.314E-5 15 246
5 int:JUNB JUNB interactions 3.727E-8 3.139E-5 2.801E-4 1.569E-4 8 52
6 int:RELA RELA interactions 8.772E-8 6.156E-5 5.493E-4 3.694E-4 16 316
7 int:MAPK8 MAPK8 interactions 1.215E-7 7.311E-5 6.523E-4 5.118E-4 13 206
8 int:CEBPA CEBPA interactions 1.606E-7 8.456E-5 7.545E-4 6.765E-4 13 211
9 int:SRA1 SRA1 interactions 1.824E-7 8.533E-5 7.614E-4 7.680E-4 7 43
10 int:FOSB FOSB interactions 2.355E-7 9.916E-5 8.848E-4 9.916E-4 5 15
11 int:CDK6 CDK6 interactions 2.626E-7 1.005E-4 8.970E-4 1.106E-3 10 119
12 int:JUND JUND interactions 3.444E-7 1.209E-4 1.079E-3 1.450E-3 7 47
13 int:EGR1 EGR1 interactions 8.036E-7 2.603E-4 2.323E-3 3.384E-3 7 53
14 int:BATF3 BATF3 interactions 1.954E-6 5.876E-4 5.243E-3 8.226E-3 5 22
15 int:ATF3 ATF3 interactions 2.657E-6 7.460E-4 6.656E-3 1.119E-2 7 63
16 int:STAT3 STAT3 interactions 2.843E-6 7.482E-4 6.676E-3 1.197E-2 13 272
17 int:IKBKG IKBKG interactions 3.397E-6 8.414E-4 7.508E-3 1.430E-2 14 321
18 int:CREBBP CREBBP interactions 3.796E-6 8.881E-4 7.924E-3 1.599E-2 15 371
19 int:ELK1 ELK1 interactions 4.183E-6 9.272E-4 8.273E-3 1.762E-2 6 44
20 int:DDIT3 DDIT3 interactions 7.209E-6 1.518E-3 1.354E-2 3.036E-2 7 73
21 int:HIVEP1 HIVEP1 interactions 8.972E-6 1.799E-3 1.605E-2 3.778E-2 6 50
22 int:BAG1 BAG1 interactions 1.030E-5 1.890E-3 1.686E-2 4.336E-2 7 77
23 int:TCF4 TCF4 interactions 1.064E-5 1.890E-3 1.686E-2 4.480E-2 11 219
24 int:STIP1 STIP1 interactions 1.094E-5 1.890E-3 1.686E-2 4.609E-2 9 142
25 int:SOCS3 SOCS3 interactions 1.122E-5 1.890E-3 1.686E-2 4.725E-2 7 78
26 int:JUN JUN interactions 1.197E-5 1.904E-3 1.699E-2
5.042E-2
 12 265
27 int:NFATC1 NFATC1 interactions 1.221E-5 1.904E-3 1.699E-2
5.142E-2
 7 79
28 int:MAPK9 MAPK9 interactions 1.341E-5 2.017E-3 1.800E-2
5.648E-2
 8 111
29 int:GADD45B GADD45B interactions 1.474E-5 2.070E-3 1.847E-2
6.209E-2
 4 16
30 int:ELK4 ELK4 interactions 1.474E-5 2.070E-3 1.847E-2
6.209E-2
 4 16
31 int:FOSL1 FOSL1 interactions 1.614E-5 2.192E-3 1.956E-2
6.796E-2
 5 33
32 int:FOSL2 FOSL2 interactions 1.936E-5 2.452E-3 2.188E-2
8.153E-2
 6 57
33 int:MAP2K7 MAP2K7 interactions 1.936E-5 2.452E-3 2.188E-2
8.153E-2
 6 57
34 int:TRA2B TRA2B interactions 1.980E-5 2.452E-3 2.188E-2
8.336E-2
 7 85
35 int:CUL5 CUL5 interactions 2.139E-5 2.574E-3 2.297E-2
9.009E-2
 15 429
36 int:SMARCB1 SMARCB1 interactions 2.230E-5 2.576E-3 2.299E-2
9.391E-2
 8 119
37 int:KAT2B KAT2B interactions 2.264E-5 2.576E-3 2.299E-2
9.532E-2
 10 195
38 int:SKP2 SKP2 interactions 2.370E-5 2.626E-3 2.343E-2
9.979E-2
 8 120
39 int:GSK3B GSK3B interactions 3.817E-5 4.088E-3 3.647E-2
1.607E-1
 12 298
40 int:VHL VHL interactions 3.943E-5 4.088E-3 3.647E-2
1.660E-1
 12 299
41 int:FOS FOS interactions 3.980E-5 4.088E-3 3.647E-2
1.676E-1
 9 167
42 int:ELOC ELOC interactions 4.217E-5 4.228E-3 3.773E-2
1.776E-1
 8 130
43 int:GATA4 GATA4 interactions 4.784E-5 4.649E-3 4.149E-2
2.014E-1
 5 41
44 int:MAPK1 MAPK1 interactions 4.934E-5 4.649E-3 4.149E-2
2.078E-1
 12 306
45 int:BTRC BTRC interactions 4.968E-5 4.649E-3 4.149E-2
2.092E-1
 13 356
46 int:SRSF3 SRSF3 interactions 5.235E-5 4.792E-3 4.276E-2
2.204E-1
 8 134
47 int:RIN3 RIN3 interactions 6.048E-5 5.419E-3 4.835E-2
2.547E-1
 5 43
48 int:YY1 YY1 interactions 6.786E-5 5.954E-3
5.312E-2
2.858E-1
 8 139
49 int:MYF6 MYF6 interactions 7.427E-5 6.383E-3
5.695E-2
3.128E-1
 3 9
50 int:NRBP1 NRBP1 interactions 9.567E-5 8.057E-3
7.189E-2
4.029E-1
 4 25
Show 45 more annotations

10: Cytoband [Display Chart] 148 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9q22 9q22 9.705E-5 1.436E-2
8.012E-2
 1.436E-2 3 19

11: Transcription Factor Binding Site [Display Chart] 538 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$CREBP1 Q2 V$CREBP1 Q2 3.520E-11 1.894E-8 1.300E-7 1.894E-8 18 196
2 CGTSACG V$PAX3 B CGTSACG V$PAX3 B 8.924E-11 2.400E-8 1.648E-7 4.801E-8 14 111
3 GTGACGY V$E4F1 Q6 GTGACGY V$E4F1 Q6 3.792E-10 6.801E-8 4.669E-7 2.040E-7 26 497
4 V$ATF 01 V$ATF 01 1.665E-9 2.239E-7 1.537E-6 8.955E-7 17 218
5 V$CREB Q2 V$CREB Q2 5.940E-9 6.391E-7 4.388E-6 3.196E-6 16 207
6 V$ATF3 Q6 V$ATF3 Q6 3.159E-8 2.833E-6 1.945E-5 1.700E-5 15 202
7 V$CREB Q4 V$CREB Q4 2.354E-7 1.682E-5 1.155E-4 1.266E-4 14 203
8 V$ATF4 Q2 V$ATF4 Q2 2.501E-7 1.682E-5 1.155E-4 1.345E-4 14 204
9 V$CREB Q2 01 V$CREB Q2 01 4.362E-7 2.607E-5 1.790E-4 2.347E-4 13 182
10 V$E4F1 Q6 V$E4F1 Q6 6.641E-7 3.573E-5 2.453E-4 3.573E-4 14 221
11 V$HNF3 Q6 V$HNF3 Q6 7.381E-7 3.610E-5 2.478E-4 3.971E-4 12 160
12 V$SRF 01 V$SRF 01 1.289E-6 5.778E-5 3.967E-4 6.933E-4 7 45
13 V$CREB Q4 01 V$CREB Q4 01 1.500E-6 6.208E-5 4.262E-4 8.070E-4 12 171
14 V$TAXCREB 01 V$TAXCREB 01 1.694E-6 6.509E-5 4.469E-4 9.113E-4 10 115
15 V$ATF6 01 V$ATF6 01 3.335E-6 1.145E-4 7.862E-4 1.794E-3 9 97
16 V$PAX3 B V$PAX3 B 3.405E-6 1.145E-4 7.862E-4 1.832E-3 8 73
17 V$FOXD3 01 V$FOXD3 01 6.492E-6 1.962E-4 1.347E-3 3.493E-3 11 164
18 V$HSF2 01 V$HSF2 01 6.564E-6 1.962E-4 1.347E-3 3.531E-3 12 197
19 V$WHN B V$WHN B 7.663E-6 2.170E-4 1.490E-3 4.123E-3 12 200
20 RGAANNTTC V$HSF1 01 RGAANNTTC V$HSF1 01 9.007E-6 2.423E-4 1.664E-3 4.846E-3 16 355
21 V$HNF3ALPHA Q6 V$HNF3ALPHA Q6 1.082E-5 2.771E-4 1.903E-3 5.820E-3 11 173
22 V$CEBPB 01 V$CEBPB 01 1.142E-5 2.793E-4 1.918E-3 6.144E-3 12 208
23 V$HSF1 01 V$HSF1 01 1.320E-5 3.087E-4 2.120E-3 7.101E-3 12 211
24 V$SRF C V$SRF C 1.658E-5 3.704E-4 2.543E-3 8.921E-3 11 181
25 V$CEBP Q2 01 V$CEBP Q2 01 1.750E-5 3.704E-4 2.543E-3 9.413E-3 12 217
26 V$FREAC4 01 V$FREAC4 01 1.790E-5 3.704E-4 2.543E-3 9.631E-3 9 119
27 V$BACH1 01 V$BACH1 01 2.007E-5 3.999E-4 2.746E-3 1.080E-2 12 220
28 WYAAANNRNNNGCG UNKNOWN WYAAANNRNNNGCG UNKNOWN 2.186E-5 4.200E-4 2.884E-3 1.176E-2 6 46
29 V$CEBPDELTA Q6 V$CEBPDELTA Q6 2.365E-5 4.388E-4 3.013E-3 1.272E-2 11 188
30 V$ATF B V$ATF B 2.728E-5 4.755E-4 3.265E-3 1.467E-2 10 157
31 V$ATF1 Q6 V$ATF1 Q6 2.740E-5 4.755E-4 3.265E-3 1.474E-2 11 191
32 V$SRF Q4 V$SRF Q4 2.876E-5 4.835E-4 3.320E-3 1.547E-2 11 192
33 V$BACH2 01 V$BACH2 01 3.544E-5 5.777E-4 3.967E-3 1.906E-2 12 233
34 V$STAT5B 01 V$STAT5B 01 4.589E-5 7.261E-4 4.986E-3 2.469E-2 11 202
35 V$YY1 01 V$YY1 01 5.250E-5 8.070E-4 5.541E-3 2.824E-2 11 205
36 V$STAT6 01 V$STAT6 01 5.991E-5 8.953E-4 6.147E-3 3.223E-2 11 208
37 V$CREB 01 V$CREB 01 7.118E-5 1.035E-3 7.106E-3 3.829E-2 11 212
38 V$NFAT Q4 01 V$NFAT Q4 01 8.078E-5 1.119E-3 7.686E-3 4.346E-2 11 215
39 SMTTTTGT UNKNOWN SMTTTTGT UNKNOWN 8.275E-5 1.119E-3 7.686E-3 4.452E-2 14 337
40 V$HNF3B 01 V$HNF3B 01 8.323E-5 1.119E-3 7.686E-3 4.478E-2 10 179
41 TTCNRGNNNNTTC V$HSF Q6 TTCNRGNNNNTTC V$HSF Q6 1.089E-4 1.430E-3 9.815E-3
5.861E-2
 8 117
42 V$CEBP Q2 V$CEBP Q2 1.146E-4 1.467E-3 1.007E-2
6.163E-2
 10 186
43 V$CHOP 01 V$CHOP 01 1.489E-4 1.862E-3 1.279E-2
8.008E-2
 10 192
44 V$SRF Q5 01 V$SRF Q5 01 1.621E-4 1.982E-3 1.361E-2
8.719E-2
 10 194
45 V$CREB 02 V$CREB 02 1.995E-4 2.333E-3 1.602E-2
1.073E-1
 10 199
46 V$SRY 02 V$SRY 02 1.995E-4 2.333E-3 1.602E-2
1.073E-1
 10 199
47 V$E2F1 Q3 01 V$E2F1 Q3 01 2.078E-4 2.334E-3 1.602E-2
1.118E-1
 10 200
48 V$HFH3 01 V$HFH3 01 2.082E-4 2.334E-3 1.602E-2
1.120E-1
 9 163
49 TGAYRTCA V$ATF3 Q6 TGAYRTCA V$ATF3 Q6 3.149E-4 3.442E-3 2.363E-2
1.694E-1
 15 430
50 V$CEBPB 02 V$CEBPB 02 3.198E-4 3.442E-3 2.363E-2
1.721E-1
 10 211
Show 45 more annotations

12: Gene Family [Display Chart] 91 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 506 Basic leucine zipper proteins genenames.org 6.286E-10 5.720E-8 2.914E-7 5.720E-8 8 49
2 1257 Basic leucine zipper proteins|Jun transcription factor family genenames.org 2.333E-7 1.061E-5 5.407E-5 2.123E-5 3 3
3 624 Zinc fingers C2H2-type|Kruppel like factors genenames.org 4.036E-6 1.011E-4 5.150E-4 3.673E-4 4 18
4 1309 BTG/Tob family genenames.org 4.603E-6 1.011E-4 5.150E-4 4.188E-4 3 6
5 420 Basic helix-loop-helix proteins genenames.org 5.555E-6 1.011E-4 5.150E-4 5.055E-4 7 110
6 737 RNA binding motif containing|Serine and arginine rich splicing factors genenames.org 4.927E-5 7.473E-4 3.806E-3 4.484E-3 3 12
7 583 Heat shock 70kDa proteins genenames.org 1.489E-4 1.935E-3 9.858E-3 1.355E-2 3 17
8 1256 Basic leucine zipper proteins|Fos transcription factor family genenames.org 2.275E-4 2.588E-3 1.318E-2 2.071E-2 2 4
9 959 Caspases|Caspase recruitment domain containing genenames.org 8.381E-4 8.474E-3 4.317E-2
7.627E-2
 3 30
10 895 MAP kinase phosphatases genenames.org 2.027E-3 1.845E-2
9.397E-2
1.845E-1
 2 11
11 584 DNAJ (HSP40) heat shock proteins|C2 tensin-type domain containing genenames.org 3.492E-3 2.648E-2
1.349E-1
3.177E-1
 3 49
12 71 Nuclear hormone receptors genenames.org 3.492E-3 2.648E-2
1.349E-1
3.177E-1
 3 49
13 418 AT-rich interaction domain containing genenames.org 3.808E-3 2.666E-2
1.358E-1
3.465E-1
 2 15
14 390 Rho family GTPases genenames.org 6.753E-3 4.389E-2
2.236E-1
6.145E-1
 2 20
15 720 Endogenous ligands|Regulators of G-protein signaling genenames.org 7.433E-3 4.510E-2
2.297E-1
6.764E-1
 2 21
Show 10 more annotations

13: Coexpression [Display Chart] 6796 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5890 Genes regulated by NF-kB in response to TNF [GeneID=7124]. MSigDB H: Hallmark Gene Sets (v5.1) 2.121E-68 1.442E-64 1.355E-63 1.442E-64 53 200
2 M11585 Genes up-regulated in MCF7 cells (breast cancer) after stimulation with NRG1 [GeneID=3084]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.516E-62 5.150E-59 4.842E-58 1.030E-58 48 175
3 M16311 Genes up-regulated in MCF7 cells (breast cancer) after stimulation with EGF [GeneID=1950]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.714E-56 1.294E-52 1.217E-51 3.883E-52 33 58
4 GSE19923 WT VS HEB AND E2A KO DP THYMOCYTE DN Genes down-regulated in double positive thymocytes: wildtype versus TCF3 and TCF12 [GeneID=6929;6938] knockout. MSigDB C7: Immunologic Signatures (v5.1) 3.518E-44 4.782E-41 4.496E-40 2.391E-40 39 200
5 M3497 Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 40 min. MSigDB C7: Immunologic Signatures (v5.1) 3.518E-44 4.782E-41 4.496E-40 2.391E-40 39 200
6 M3499 Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 60 min. MSigDB C7: Immunologic Signatures (v5.1) 2.080E-39 2.356E-36 2.215E-35 1.414E-35 36 200
7 M4781 Down-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.648E-39 2.571E-36 2.417E-35 1.800E-35 32 134
8 M7928 Genes up-regulated in the MM1S cells (multiple myeloma) after treatment with aplidin [PubChem=44152164], a marine-derived compound with potential anti-cancer properties. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.526E-38 3.845E-35 3.615E-34 3.076E-34 45 439
9 M1597 Cluster 2: genes maximally expressed at 2 h time point during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) in response to adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.967E-36 4.506E-33 4.236E-32 4.055E-32 23 51
10 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.397E-35 5.707E-32 5.365E-31 5.707E-31 42 425
11 M16336 Up-regulated genes in MM1.S cells (multiple myeloma) treated with adaphostin [PubChem=387042], a tyrosine kinase inhibitor with anticancer properties. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.297E-34 8.016E-32 7.536E-31 8.817E-31 30 147
12 M2613 Class III of genes transiently induced by EGF [GeneID =1950] in 184A1 cells (mammary epithelium). MSigDB C2: CGP Curated Gene Sets (v5.1) 3.123E-33 1.769E-30 1.663E-29 2.122E-29 33 222
13 GSE36891 POLYIC TLR3 VS PAM TLR2 STIM PERITONEAL MACROPHAGE UP Genes up-regulated in peritoneal macrophages: poly(IC) versus Pam3Cys-Ser-(Lys)4 [PubChem=130704]. MSigDB C7: Immunologic Signatures (v5.1) 4.202E-33 2.197E-30 2.065E-29 2.856E-29 29 146
14 GSE37605 TREG VS TCONV NOD FOXP3 FUSION GFP UP Genes up-regulated in splenocytes from Foxp3-Fusion-GFP NOD mice: T reg (FOXP3+ [GeneID=50943]) versus T conv (FOXP3- [GeneID=50943]) cells. MSigDB C7: Immunologic Signatures (v5.1) 7.003E-32 3.399E-29 3.196E-28 4.759E-28 28 142
15 M9162 Genes up-regulated in HUVEC cells (primary endothelium) after stimulation with leukotriene LTD4 [PubChem=3908] or thrombin (F2) [GeneID=2147] for 1 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.895E-31 1.312E-28 1.233E-27 1.967E-27 19 37
16 M5875 Genes up-regulated in comparison of monocytes treated with anti-TREM1 [GeneID=54210] and 5000 ng/ml LPS (TLR4 agonist) versus monocytes treated with control IgG. MSigDB C7: Immunologic Signatures (v5.1) 1.465E-30 6.221E-28 5.849E-27 9.954E-27 30 197
17 M3502 Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 80 min. MSigDB C7: Immunologic Signatures (v5.1) 2.348E-30 8.865E-28 8.334E-27 1.596E-26 30 200
18 GSE23925 LIGHT ZONE VS NAIVE BCELL UP Genes up-regulated in B cells: light zone versus naïve. MSigDB C7: Immunologic Signatures (v5.1) 2.348E-30 8.865E-28 8.334E-27 1.596E-26 30 200
19 GSE37605 FOXP3 FUSION GFP VS IRES GFP TREG C57BL6 UP Genes up-regulated in T reg (FOXP3+ [GeneID=50943]) cells from B6 mice: Foxp3-Fusion-GFP versus Foxp3-ires-GFP. MSigDB C7: Immunologic Signatures (v5.1) 3.758E-30 1.344E-27 1.264E-26 2.554E-26 29 182
20 M12383 Genes up-regulated in hematopoietic stem cells (HSC, CD34+ [GeneID=947]) cultured in a three-dimentional collagen gel compared to the cells grown in suspension. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.500E-30 3.228E-27 3.035E-26 6.456E-26 31 232
21 M4204 Genes whose expression peaked at 40 min after stimulation of HeLa cells with EGF [GeneID=1950]. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.225E-28 2.662E-25 2.502E-24 5.590E-24 18 42
22 M17621 Genes up-regulated 9 h after induction of HoxA5 [GeneID=3205] expression in a breast cancer cell line. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.666E-27 5.050E-25 4.747E-24 1.132E-23 29 223
23 GSE27434 WT VS DNMT1 KO TREG DN Genes down-regulated in T reg: wildtype versus DNMT1 [GeneID=1786] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.709E-27 5.050E-25 4.747E-24 1.161E-23 28 200
24 M12338 Genes changed in NIH 3T3 cells (embryonic fibroblast) by expression of one or more of C/EBP proteins: CEBPA, CEBPB, CEBPG, and CEBPD [GeneID=1050;1051;1054;1052]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.967E-27 1.406E-24 1.322E-23 3.375E-23 24 126
25 M4930 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v5.1) 3.249E-26 8.832E-24 8.304E-23 2.208E-22 27 198
26 M1304 Genes down-regulated in SEND cells (skin endothelium) at hypoxia with ELK3 [GeneID=2004] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.864E-26 1.010E-23 9.496E-23 2.626E-22 25 156
27 GSE19401 NAIVE VS IMMUNIZED MOUSE PLN FOLLICULAR DC UP Genes up-regulated in ex vivo follicular dendritic cells from peripheral lymph nodes: naïve versus immunized mice. MSigDB C7: Immunologic Signatures (v5.1) 4.292E-26 1.080E-23 1.016E-22 2.917E-22 27 200
28 M2496 Genes up-regulated in Calu-6 cells (lung cancer) at 1 h time point after TNF [GeneID=7124] treatment. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.500E-26 2.063E-23 1.940E-22 5.776E-22 19 63
29 M1317 Genes up-regulated in SEND cells (skin endothelium) at hypoxia after knockdown of ELK3 [GeneID=2004] and HIF1A [GeneID=3091] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.047E-25 2.455E-23 2.308E-22 7.118E-22 24 142
30 GSE7219 WT VS NIK NFKB2 KO DC UP Genes up-regulated in dendritic cells: wildtype versus NFKB2 [GeneID=4791]. MSigDB C7: Immunologic Signatures (v5.1) 1.111E-25 2.516E-23 2.366E-22 7.549E-22 26 184
31 M15891 Genes down-regulated in MEF cells (embryonic fibroblasts) with TERT [GeneID=7015] knockout, after expression of the gene off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.340E-25 2.938E-23 2.762E-22 9.108E-22 14 21
32 M1417 Genes down-regulated during epithelial to mesenchymal transition (EMT) induced by TGFB1 [GeneID=7040] in the EpH4 cells (mammary epithelium cell line transformed by HRAS [GeneID=3265]). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.353E-25 4.997E-23 4.698E-22 1.599E-21 19 66
33 GSE42021 CD24HI TREG VS CD24HI TCONV THYMUS DN Genes down-regulated in CD42 high [GeneID=100133941] cells from thymus: T reg versus T conv. MSigDB C7: Immunologic Signatures (v5.1) 8.985E-25 1.850E-22 1.740E-21 6.106E-21 26 199
34 M5891 Genes up-regulated in response to low oxygen levels (hypoxia). MSigDB H: Hallmark Gene Sets (v5.1) 1.026E-24 1.993E-22 1.874E-21 6.975E-21 26 200
35 GSE23925 DARK ZONE VS NAIVE BCELL DN Genes down-regulated in B cells: dark zone versus naïve. MSigDB C7: Immunologic Signatures (v5.1) 1.026E-24 1.993E-22 1.874E-21 6.975E-21 26 200
36 M2858 Genes up-regulated in NOMO-1 and SKM-1 cells (AML) after knockdown of STK33 [Gene ID=65975] by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 2.906E-24 5.486E-22 5.158E-21 1.975E-20 29 288
37 GSE37605 C57BL6 VS NOD FOXP3 FUSION GFP TREG DN Genes down-regulated in Foxp3-Fusion-GFP T reg (FOXP3+ [GeneID=50943]): B6 versus NOD background. MSigDB C7: Immunologic Signatures (v5.1) 3.669E-24 6.738E-22 6.335E-21 2.493E-20 25 186
38 GSE36891 UNSTIM VS POLYIC TLR3 STIM PERITONEAL MACROPHAGE UP Genes up-regulated in peritoneal macrophages: untreated versus poly(IC). MSigDB C7: Immunologic Signatures (v5.1) 7.341E-24 1.313E-21 1.234E-20 4.989E-20 23 147
39 M19693 Genes up-regulated in NHEK cells (normal keratinocytes) by UV-B irradiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.898E-24 1.725E-21 1.621E-20 6.727E-20 27 244
40 M5293 Genes up-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from young donors versus those treated with TSST at 72 h. MSigDB C7: Immunologic Signatures (v5.1) 2.054E-23 3.491E-21 3.282E-20 1.396E-19 25 199
41 GSE42021 TREG PLN VS CD24HI TREG THYMUS UP Genes up-regulated in T reg: peripheral lymph nodes versus thymic CD24 high [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v5.1) 2.333E-23 3.775E-21 3.549E-20 1.586E-19 25 200
42 M5787 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with type 1 diabetes at the time of the diagnosis versus those at 4 months later. MSigDB C7: Immunologic Signatures (v5.1) 2.333E-23 3.775E-21 3.549E-20 1.586E-19 25 200
43 M2038 Genes up-regulated in APL (acute promyeolocytic leukemia) blasts expressing PML-RARA fusion [GeneID=5371;5914] compared to normal promyeloblasts. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.550E-23 4.031E-21 3.789E-20 1.733E-19 24 177
44 GSE24671 CTRL VS BAKIMULC INFECTED MOUSE SPLENOCYTES DN Genes down-regulated in splenocytes: control versus infected with Baki-1 MuLV virus. MSigDB C7: Immunologic Signatures (v5.1) 1.528E-22 2.360E-20 2.219E-19 1.039E-18 23 167
45 M5867 Genes up-regulated in comparison of monocytes treated with 1 ng/ml LPS (TLR4 agonist) versus monocytes treated with control IgG. MSigDB C7: Immunologic Signatures (v5.1) 3.947E-22 5.961E-20 5.604E-19 2.682E-18 24 198
46 GSE46606 UNSTIM VS CD40L IL2 IL5 1DAY STIMULATED IRF4HIGH SORTED BCELL DN Genes down-regulated in at day 0 B cell IRF4-KO versus CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell IRF4high. MSigDB C7: Immunologic Signatures (v5.1) 5.037E-22 7.313E-20 6.876E-19 3.423E-18 24 200
47 M11519 Genes whose expression peaked at 40 min after stimulation of MCF10A cells with serum. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.058E-22 7.313E-20 6.876E-19 3.437E-18 14 32
48 M2857 Genes up-regulated in SKM-1 cells (AML) after knockdown of STK33 [Gene ID=65975] by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 5.266E-22 7.455E-20 7.009E-19 3.579E-18 27 283
49 M2502 Genes whose expression changes in Calu-6 cells (lung cancer) by TNF [GeneID=7124] were blocked partially by p38 inhibitor LY479754. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.387E-21 1.924E-19 1.809E-18 9.427E-18 22 160
50 M4716 Genes up-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402], a protease inhibitor causing apoptosis. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.047E-21 2.782E-19 2.615E-18 1.391E-17 25 239
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 3029 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 1.231E-66 3.728E-63 3.203E-62 3.728E-63 68 496
2 PCBC ratio EB BM CD34+ vs EB blastocyst cfr-2X-p05 EB BM CD34+ vs EB blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.554E-50 2.353E-47 2.022E-46 4.706E-47 34 83
3 gudmap dev gonad e11.5 M GonMes Sma k3 500 dev gonad e11.5 M GonMes Sma k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.389E-41 4.431E-38 3.808E-37 1.329E-37 27 62
4 gudmap dev gonad e11.5 F GonMes Sma 500 dev gonad e11.5 F GonMes Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.108E-38 8.389E-36 7.209E-35 3.355E-35 46 437
5 PCBC ratio EB from-OSK-L-l-p53KD vs EB from-ESC cfr-2X-p05 Embryoid Body Cells-reprogram OSK-L-l-p53KD vs Embryoid Body Cells-reprogram NA-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.394E-38 8.444E-36 7.256E-35 4.222E-35 28 84
6 gudmap dev gonad e11.5 M GonMes Sma 500 dev gonad e11.5 M GonMes Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.454E-37 7.338E-35 6.306E-34 4.403E-34 45 433
7 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 9.324E-36 4.035E-33 3.467E-32 2.824E-32 44 445
8 gudmap dev gonad e11.5 M GonMes Sma k4 200 dev gonad e11.5 M GonMes Sma k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 2.061E-33 7.804E-31 6.707E-30 6.243E-30 19 30
9 endothelial Top 500 Cluster 2 endothelial Top 500 Cluster 2 Brain Map - Barres 4.066E-30 1.368E-27 1.176E-26 1.232E-26 22 68
10 gudmap dev gonad e11.5 F GonMes Sma k4 200 dev gonad e11.5 F GonMes Sma k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 8.874E-29 2.688E-26 2.310E-25 2.688E-25 17 30
11 GSM538239 500 Myeloid Cells, DC.103-11b+.Lv, CD45+ CD11c+ MHC-II + CD11b high CD103-, Liver, avg-3 Immgen.org, GSE15907 1.706E-28 4.698E-26 4.037E-25 5.167E-25 37 411
12 GSM854271 500 Myeloid Cells, DC.103-11b+24-.Lu, MHCII+ CD11c+ CD103- CD11b+ CD24-, Lung, avg-2 Immgen.org, GSE15907 2.220E-28 5.603E-26 4.815E-25 6.723E-25 37 414
13 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 1.693E-27 3.945E-25 3.390E-24 5.128E-24 37 438
14 gudmap dev gonad e11.5 M GonMes Sma 200 dev gonad e11.5 M GonMes Sma top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 3.593E-27 7.773E-25 6.680E-24 1.088E-23 27 176
15 GSM538280 500 Myeloid Cells, DC.LC.Sk, MHCII+ CD11b+ CD45+, Skin, avg-2 Immgen.org, GSE15907 5.232E-27 1.057E-24 9.079E-24 1.585E-23 37 452
16 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 6.629E-27 1.255E-24 1.078E-23 2.008E-23 37 455
17 endothelial SubClass DCN-hi Top 500 All endothelial SubClass DCN-hi Top 500 All Brain Map - Barres 1.011E-26 1.802E-24 1.549E-23 3.064E-23 38 495
18 GSM777037 500 Stromal Cells, BEC.SLN, gp38- CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.247E-25 2.098E-23 1.803E-22 3.777E-22 36 459
19 GSM854269 500 Myeloid Cells, DC.103-11b+24+.Lu, MHCII+ CD11c+ CD103- CD11b+ CD24+, Lung, avg-2 Immgen.org, GSE15907 3.251E-25 5.183E-23 4.454E-22 9.848E-22 34 404
20 GSM854232 500 Myeloid Cells, DC.103+11b+.Salm3.SI, CD45+ MHCII+ Gr1- CD11c-hi CD11b+ CD103+ F480-, Small Intestine, avg-5 Immgen.org, GSE15907 5.957E-25 9.022E-23 7.753E-22 1.804E-21 33 379
21 GSM605820 500 Myeloid Cells, DC.103+11b-.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3 Immgen.org, GSE15907 9.070E-25 1.277E-22 1.097E-21 2.747E-21 33 384
22 gudmap dev gonad e11.5 F GonMes Sma k3 500 dev gonad e11.5 F GonMes Sma k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 9.275E-25 1.277E-22 1.097E-21 2.809E-21 24 149
23 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 1.063E-24 1.399E-22 1.203E-21 3.219E-21 35 453
24 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 1000 k3 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.974E-24 3.753E-22 3.225E-21 9.008E-21 29 277
25 gudmap dev gonad e11.5 F GonMes Sma 200 dev gonad e11.5 F GonMes Sma top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 6.578E-24 7.969E-22 6.848E-21 1.992E-20 25 183
26 GSM854338 500 Myeloid Cells, GN.Arth.SynF, CD11b+ Ly6-G+, Synovial Fluid, avg-3 Immgen.org, GSE15907 1.356E-23 1.579E-21 1.357E-20 4.106E-20 33 418
27 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 500 k4 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.050E-23 2.300E-21 1.976E-20 6.210E-20 17 53
28 GSM854280 500 Myeloid Cells, DC.11cloSer.SI, CD45+ MHCII+ CD11c-lo CD11b+, Small Intestine, avg-5 Immgen.org, GSE15907 1.035E-22 1.120E-20 9.625E-20 3.136E-19 31 377
29 GSM777032 500 Stromal Cells, BEC.MLN, gp38- CD31+, Lymph Node, avg-5 Immgen.org, GSE15907 2.106E-22 2.200E-20 1.891E-19 6.380E-19 33 456
30 gudmap dev gonad e11.5 M ReproVasc Flk k2 1000 dev gonad e11.5 M ReproVasc Flk k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.280E-22 2.302E-20 1.979E-19 6.907E-19 19 88
31 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 4.442E-22 4.340E-20 3.729E-19 1.345E-18 33 467
32 GSM854237 500 Myeloid Cells, DC.103+11b+.SI, CD45+ MHCII+ CD11c-hi CD11b+ CD103+ F4/80-lo, Small Intestine, avg-4 Immgen.org, GSE15907 1.198E-21 1.134E-19 9.743E-19 3.628E-18 30 375
33 GSM538231 500 Myeloid Cells, DC.103+11b-.Lu, CD11chi CD11b low CD103+ MHCII+ SiglecF-, Lung, avg-3 Immgen.org, GSE15907 3.386E-21 3.027E-19 2.601E-18 1.026E-17 31 424
34 gudmap dev gonad e11.5 M GonMes Sma k2 1000 dev gonad e11.5 M GonMes Sma k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.398E-21 3.027E-19 2.601E-18 1.029E-17 17 69
35 GSM854241 500 Myeloid Cells, DC.103+11b-.Lu, MHCII+ CD11c+ CD103+ CD11b, Lung, avg-2 Immgen.org, GSE15907 8.809E-21 7.623E-19 6.551E-18 2.668E-17 30 402
36 GSM605823 500 Myeloid Cells, DC.103-11b+.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3 Immgen.org, GSE15907 1.442E-20 1.213E-18 1.042E-17 4.367E-17 30 409
37 GSM777063 500 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.940E-20 1.578E-18 1.356E-17 5.878E-17 31 450
38 gudmap dev gonad e11.5 M GonMes Sma k3 1000 dev gonad e11.5 M GonMes Sma k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.980E-20 1.578E-18 1.356E-17 5.997E-17 27 312
39 endothelial Top 500 Cluster 1 endothelial Top 500 Cluster 1 Brain Map - Barres 3.161E-20 2.455E-18 2.110E-17 9.576E-17 13 30
40 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 500 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.014E-20 3.040E-18 2.612E-17 1.216E-16 30 424
41 gudmap dev gonad e11.5 F GonMes Sma k4 1000 dev gonad e11.5 F GonMes Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 7.298E-20 5.392E-18 4.633E-17 2.211E-16 27 328
42 GSM854276 500 Myeloid Cells, DC.11cloSer.Salm3.SI, CD45+ MHCII+ Gr1- CD11c-lo CD11b+, Small Intestine, avg-4 Immgen.org, GSE15907 8.748E-20 6.309E-18 5.421E-17 2.650E-16 28 364
43 GSM854251 500 Myeloid Cells, DC.103+11b-.SI, CD45+ MHCII+ CD11c-hi CD103+ CD11b-, Small Intestine, avg-4 Immgen.org, GSE15907 1.563E-19 1.101E-17 9.462E-17 4.735E-16 28 372
44 gudmap dev gonad e11.5 F GonMes Sma k3 1000 dev gonad e11.5 F GonMes Sma k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.494E-19 1.717E-17 1.476E-16 7.555E-16 16 71
45 OPC Top 500 All OPC Top 500 All Brain Map - Barres 2.909E-19 1.958E-17 1.683E-16 8.813E-16 31 494
46 PCBC ratio SC-LF blastocyst vs SC blastocyst cfr-2X-p05 SC-LF blastocyst vs SC blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 8.221E-19 5.413E-17 4.652E-16 2.490E-15 28 396
47 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 200 k1 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.571E-18 2.301E-16 1.978E-15 1.082E-14 11 22
48 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 1000 k2 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.670E-18 2.316E-16 1.990E-15 1.112E-14 17 101
49 gudmap dev gonad e11.5 F ReproVasc Flk k4 1000 dev gonad e11.5 F ReproVasc Flk k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 4.858E-18 3.003E-16 2.581E-15 1.472E-14 15 68
50 endothelial Top 500 Cluster 0 endothelial Top 500 Cluster 0 Brain Map - Barres 1.041E-17 6.306E-16 5.419E-15 3.153E-14 18 128
Show 45 more annotations

15: Computational [Display Chart] 445 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 2.000E-22 8.900E-20 5.942E-19 8.900E-20 37 361
2 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 2.420E-13 5.384E-11 3.594E-10 1.077E-10 28 378
3 module 6 Genes in module 6 MSigDb: C4 - CM: Cancer Modules 3.222E-10 4.780E-8 3.191E-7 1.434E-7 25 407
4 module 15 Genes in module 15 MSigDb: C4 - CM: Cancer Modules 1.530E-8 1.431E-6 9.557E-6 6.808E-6 21 350
5 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 1.608E-8 1.431E-6 9.557E-6 7.157E-6 21 351
6 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 8.744E-8 6.485E-6 4.330E-5 3.891E-5 22 423
7 module 98 Genes in module 98 MSigDb: C4 - CM: Cancer Modules 3.129E-7 1.844E-5 1.231E-4 1.393E-4 20 381
8 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 3.315E-7 1.844E-5 1.231E-4 1.475E-4 21 419
9 GNF2 FOS Neighborhood of FOS MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.452E-7 2.201E-5 1.470E-4 1.981E-4 7 35
10 module 123 Genes in module 123 MSigDb: C4 - CM: Cancer Modules 1.247E-6 5.550E-5 3.705E-4 5.550E-4 15 240
11 module 19 Genes in module 19 MSigDb: C4 - CM: Cancer Modules 5.813E-6 2.351E-4 1.570E-3 2.587E-3 16 307
12 module 252 Genes in module 252 MSigDb: C4 - CM: Cancer Modules 1.713E-5 6.351E-4 4.240E-3 7.621E-3 13 227
13 module 488 Genes in module 488 MSigDb: C4 - CM: Cancer Modules 3.839E-5 1.314E-3 8.774E-3 1.708E-2 5 28
14 module 198 Genes in module 198 MSigDb: C4 - CM: Cancer Modules 5.803E-5 1.844E-3 1.231E-2 2.582E-2 14 292
15 module 399 Genes in module 399 MSigDb: C4 - CM: Cancer Modules 6.554E-5 1.944E-3 1.298E-2 2.917E-2 6 50
16 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 1.259E-4 3.503E-3 2.338E-2
5.604E-2
 16 395
17 module 456 Genes in module 456 MSigDb: C4 - CM: Cancer Modules 1.415E-4 3.704E-3 2.473E-2
6.297E-2
 8 109
18 module 3 Genes in module 3 MSigDb: C4 - CM: Cancer Modules 2.378E-4 5.879E-3 3.925E-2
1.058E-1
 15 375
19 module 573 Genes in module 573 MSigDb: C4 - CM: Cancer Modules 3.176E-4 7.438E-3 4.966E-2
1.413E-1
 4 24
20 module 75 Genes in module 75 MSigDb: C4 - CM: Cancer Modules 3.721E-4 8.279E-3
5.527E-2
1.656E-1
 15 391
21 module 105 Genes in module 105 MSigDb: C4 - CM: Cancer Modules 3.917E-4 8.299E-3
5.541E-2
1.743E-1
 10 194
22 GNF2 CD33 Neighborhood of CD33 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.374E-4 8.847E-3
5.907E-2
1.946E-1
 5 46
23 module 8 Genes in module 8 MSigDb: C4 - CM: Cancer Modules 5.529E-4 1.070E-2
7.142E-2
2.460E-1
 15 406
24 module 197 Genes in module 197 MSigDb: C4 - CM: Cancer Modules 6.341E-4 1.176E-2
7.850E-2
2.822E-1
 9 170
25 module 213 Genes in module 213 MSigDb: C4 - CM: Cancer Modules 7.688E-4 1.368E-2
9.136E-2
3.421E-1
 6 78
26 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 9.058E-4 1.550E-2
1.035E-1
4.031E-1
 10 216
27 module 474 Genes in module 474 MSigDb: C4 - CM: Cancer Modules 1.326E-3 2.186E-2
1.459E-1
5.902E-1
 3 16
28 GNF2 HDAC1 Neighborhood of HDAC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.720E-3 2.688E-2
1.795E-1
7.654E-1
 6 91
29 module 38 Genes in module 38 MSigDb: C4 - CM: Cancer Modules 1.752E-3 2.688E-2
1.795E-1
7.795E-1
 15 455
30 GNF2 CARD15 Neighborhood of CARD15 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.854E-3 2.751E-2
1.836E-1
8.252E-1
 5 63
31 module 121 Genes in module 121 MSigDb: C4 - CM: Cancer Modules 2.508E-3 3.601E-2
2.404E-1
1.000E0
 6 98
32 module 177 Genes in module 177 MSigDb: C4 - CM: Cancer Modules 2.919E-3 3.998E-2
2.669E-1
1.000E0
 6 101
33 module 46 Genes in module 46 MSigDb: C4 - CM: Cancer Modules 2.964E-3 3.998E-2
2.669E-1
1.000E0
 13 386
34 module 24 Genes in module 24 MSigDb: C4 - CM: Cancer Modules 3.812E-3 4.989E-2
3.331E-1
1.000E0
 14 445
Show 29 more annotations

16: MicroRNA [Display Chart] 1453 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 miR-181c:PicTar miR-181c:PicTar PicTar 2.143E-10 1.034E-7 8.129E-7 3.114E-7 22 500
2 TGAATGT,MIR-181C:MSigDB TGAATGT,MIR-181C:MSigDB MSigDB 3.560E-10 1.034E-7 8.129E-7 5.172E-7 21 465
3 TGAATGT,MIR-181A:MSigDB TGAATGT,MIR-181A:MSigDB MSigDB 3.560E-10 1.034E-7 8.129E-7 5.172E-7 21 465
4 TGAATGT,MIR-181B:MSigDB TGAATGT,MIR-181B:MSigDB MSigDB 3.560E-10 1.034E-7 8.129E-7 5.172E-7 21 465
5 TGAATGT,MIR-181D:MSigDB TGAATGT,MIR-181D:MSigDB MSigDB 3.560E-10 1.034E-7 8.129E-7 5.172E-7 21 465
6 hsa-miR-603:PITA hsa-miR-603:PITA TOP PITA 6.010E-10 1.456E-7 1.144E-6 8.733E-7 19 385
7 miR-144:PicTar miR-144:PicTar PicTar 4.183E-9 8.683E-7 6.824E-6 6.078E-6 19 433
8 miR-101:PicTar miR-101:PicTar PicTar 2.268E-8 2.519E-6 1.980E-5 3.295E-5 18 430
9 CAGTATT,MIR-200B:MSigDB CAGTATT,MIR-200B:MSigDB MSigDB 2.612E-8 2.519E-6 1.980E-5 3.795E-5 18 434
10 CAGTATT,MIR-200C:MSigDB CAGTATT,MIR-200C:MSigDB MSigDB 2.612E-8 2.519E-6 1.980E-5 3.795E-5 18 434
11 CAGTATT,MIR-429:MSigDB CAGTATT,MIR-429:MSigDB MSigDB 2.612E-8 2.519E-6 1.980E-5 3.795E-5 18 434
12 hsa-miR-363:PITA hsa-miR-363:PITA TOP PITA 2.685E-8 2.519E-6 1.980E-5 3.901E-5 19 486
13 hsa-miR-25:PITA hsa-miR-25:PITA TOP PITA 2.774E-8 2.519E-6 1.980E-5 4.030E-5 19 487
14 hsa-miR-92a:PITA hsa-miR-92a:PITA TOP PITA 2.774E-8 2.519E-6 1.980E-5 4.030E-5 19 487
15 hsa-miR-367:PITA hsa-miR-367:PITA TOP PITA 2.774E-8 2.519E-6 1.980E-5 4.030E-5 19 487
16 hsa-miR-92b:PITA hsa-miR-92b:PITA TOP PITA 2.774E-8 2.519E-6 1.980E-5 4.030E-5 19 487
17 miR-32:PicTar miR-32:PicTar PicTar 3.693E-8 3.157E-6 2.481E-5 5.366E-5 18 444
18 TATTATA,MIR-374:MSigDB TATTATA,MIR-374:MSigDB MSigDB 5.516E-8 4.453E-6 3.500E-5 8.015E-5 14 266
19 hsa-miR-377:PITA hsa-miR-377:PITA TOP PITA 6.102E-8 4.666E-6 3.667E-5 8.866E-5 18 459
20 miR-92:PicTar miR-92:PicTar PicTar 7.268E-8 5.280E-6 4.150E-5 1.056E-4 17 413
21 hsa-miR-101:PITA hsa-miR-101:PITA TOP PITA 1.155E-7 7.872E-6 6.186E-5 1.679E-4 18 479
22 hsa-miR-32:PITA hsa-miR-32:PITA TOP PITA 1.192E-7 7.872E-6 6.186E-5 1.732E-4 18 480
23 GTGCAAT,MIR-367:MSigDB GTGCAAT,MIR-367:MSigDB MSigDB 1.535E-7 8.146E-6 6.402E-5 2.231E-4 14 289
24 GTGCAAT,MIR-92:MSigDB GTGCAAT,MIR-92:MSigDB MSigDB 1.535E-7 8.146E-6 6.402E-5 2.231E-4 14 289
25 GTGCAAT,MIR-25:MSigDB GTGCAAT,MIR-25:MSigDB MSigDB 1.535E-7 8.146E-6 6.402E-5 2.231E-4 14 289
26 GTGCAAT,MIR-32:MSigDB GTGCAAT,MIR-32:MSigDB MSigDB 1.535E-7 8.146E-6 6.402E-5 2.231E-4 14 289
27 GTGCAAT,MIR-363:MSigDB GTGCAAT,MIR-363:MSigDB MSigDB 1.535E-7 8.146E-6 6.402E-5 2.231E-4 14 289
28 miR-367:PicTar miR-367:PicTar PicTar 1.570E-7 8.146E-6 6.402E-5 2.281E-4 15 336
29 CATTTCA,MIR-203:MSigDB CATTTCA,MIR-203:MSigDB MSigDB 3.600E-7 1.804E-5 1.418E-4 5.231E-4 13 264
30 miR-200b:PicTar miR-200b:PicTar PicTar 4.019E-7 1.941E-5 1.525E-4 5.839E-4 17 466
31 miR-200c:PicTar miR-200c:PicTar PicTar 4.141E-7 1.941E-5 1.525E-4 6.016E-4 17 467
32 hsa-miR-410:PITA hsa-miR-410:PITA TOP PITA 4.370E-7 1.984E-5 1.559E-4 6.349E-4 15 364
33 hsa-miR-297:PITA hsa-miR-297:PITA TOP PITA 6.707E-7 2.953E-5 2.321E-4 9.745E-4 12 234
34 ATACTGT,MIR-144:MSigDB ATACTGT,MIR-144:MSigDB MSigDB 7.038E-7 3.008E-5 2.364E-4 1.023E-3 11 193
35 hsa-miR-448:PITA hsa-miR-448:PITA TOP PITA 8.824E-7 3.663E-5 2.879E-4 1.282E-3 16 438
36 GTACTGT,MIR-101:MSigDB GTACTGT,MIR-101:MSigDB MSigDB 9.570E-7 3.862E-5 3.035E-4 1.390E-3 12 242
37 miR-199a-star:PicTar miR-199a-star:PicTar PicTar 2.753E-6 1.081E-4 8.497E-4 4.001E-3 15 422
38 hsa-miR-152:PITA hsa-miR-152:PITA TOP PITA 3.132E-6 1.084E-4 8.516E-4 4.551E-3 16 483
39 hsa-miR-148a:PITA hsa-miR-148a:PITA TOP PITA 3.132E-6 1.084E-4 8.516E-4 4.551E-3 16 483
40 hsa-miR-148b:PITA hsa-miR-148b:PITA TOP PITA 3.132E-6 1.084E-4 8.516E-4 4.551E-3 16 483
41 TTTGCAC,MIR-19A:MSigDB TTTGCAC,MIR-19A:MSigDB MSigDB 3.132E-6 1.084E-4 8.516E-4 4.551E-3 16 483
42 TTTGCAC,MIR-19B:MSigDB TTTGCAC,MIR-19B:MSigDB MSigDB 3.132E-6 1.084E-4 8.516E-4 4.551E-3 16 483
43 hsa-miR-500:PITA hsa-miR-500:PITA TOP PITA 3.665E-6 1.238E-4 9.732E-4 5.325E-3 13 325
44 miR-203:PicTar miR-203:PicTar PicTar 4.327E-6 1.406E-4 1.105E-3 6.288E-3 13 330
45 hsa-miR-889:PITA hsa-miR-889:PITA TOP PITA 4.354E-6 1.406E-4 1.105E-3 6.327E-3 12 280
46 ACTGTGA,MIR-27B:MSigDB ACTGTGA,MIR-27B:MSigDB MSigDB 5.530E-6 1.710E-4 1.344E-3 8.035E-3 15 447
47 ACTGTGA,MIR-27A:MSigDB ACTGTGA,MIR-27A:MSigDB MSigDB 5.530E-6 1.710E-4 1.344E-3 8.035E-3 15 447
48 hsa-miR-1264:PITA hsa-miR-1264:PITA TOP PITA 6.489E-6 1.953E-4 1.534E-3 9.429E-3 15 453
49 hsa-miR-371-5p:PITA hsa-miR-371-5p:PITA TOP PITA 6.585E-6 1.953E-4 1.534E-3 9.567E-3 11 243
50 hsa-miR-409-3p:PITA hsa-miR-409-3p:PITA TOP PITA 7.153E-6 2.079E-4 1.634E-3 1.039E-2 12 294
Show 45 more annotations

17: Drug [Display Chart] 22502 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 D010938 Plant Oils CTD 9.914E-55 1.446E-50 1.533E-49 2.231E-50 59 496
2 1520 UP Azacyclonol [115-46-8]; Up 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 1.285E-54 1.446E-50 1.533E-49 2.892E-50 42 154
3 3771 UP Lanatoside C [17575-22-3]; Up 200; 4uM; PC3; HT HG-U133A Broad Institute CMAP 8.755E-52 6.567E-48 6.960E-47 1.970E-47 41 162
4 5826 UP Strophanthidin [66-28-4]; Up 200; 9.8uM; PC3; HT HG-U133A Broad Institute CMAP 2.695E-51 1.516E-47 1.607E-46 6.065E-47 41 166
5 1791 UP Azaguanine-8 [134-58-7]; Up 200; 26.2uM; PC3; HT HG-U133A Broad Institute CMAP 9.567E-49 4.306E-45 4.563E-44 2.153E-44 39 158
6 3770 UP Helveticoside [630-64-8]; Up 200; 7.4uM; PC3; HT HG-U133A Broad Institute CMAP 6.325E-48 2.372E-44 2.514E-43 1.423E-43 39 165
7 2210 UP Mefloquine hydrochloride [51773-92-3]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP 9.035E-47 2.904E-43 3.078E-42 2.033E-42 38 160
8 486 UP calmidazolium chloride; Up 200; 5uM; MCF7; HG-U133A Broad Institute CMAP 3.311E-46 9.314E-43 9.871E-42 7.451E-42 38 165
9 965 UP felodipine; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.160E-45 2.901E-42 3.074E-41 2.611E-41 38 170
10 6724 UP Digoxin [20830-75-5]; Up 200; 5.2uM; PC3; HT HG-U133A Broad Institute CMAP 4.411E-44 9.926E-41 1.052E-39 9.926E-40 37 169
11 4328 UP Lanatoside C [17575-22-3]; Up 200; 4uM; PC3; HT HG-U133A Broad Institute CMAP 1.844E-43 3.773E-40 3.999E-39 4.150E-39 36 159
12 5936 DN H-7 dihydrochloride; Down 200; 100uM; MCF7; HT HG-U133A Broad Institute CMAP 4.002E-42 7.505E-39 7.954E-38 9.006E-38 37 189
13 2651 UP Suloctidil [54063-56-8]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP 5.481E-42 9.487E-39 1.005E-37 1.233E-37 35 157
14 2456 UP Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; HL60; HT HG-U133A Broad Institute CMAP 6.475E-42 1.041E-38 1.103E-37 1.457E-37 36 174
15 2227 UP Terfenadine [50679-08-8]; Up 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.443E-41 2.164E-38 2.293E-37 3.246E-37 35 161
16 5671 DN Doxorubicin hydrochloride [25316-40-9]; Down 200; 6.8uM; MCF7; HT HG-U133A Broad Institute CMAP 5.736E-41 8.067E-38 8.550E-37 1.291E-36 36 184
17 5364 UP Anisomycin [22862-76-6]; Up 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 5.216E-40 6.904E-37 7.317E-36 1.174E-35 34 160
18 2886 UP Prenylamine lactate [69-43-2]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP 6.574E-40 8.218E-37 8.710E-36 1.479E-35 34 161
19 2439 UP Menadione [58-27-5]; Up 200; 23.2uM; HL60; HT HG-U133A Broad Institute CMAP 1.632E-39 1.932E-36 2.048E-35 3.672E-35 34 165
20 4610 DN Doxorubicin hydrochloride [25316-40-9]; Down 200; 6.8uM; PC3; HT HG-U133A Broad Institute CMAP 2.307E-39 2.595E-36 2.751E-35 5.191E-35 35 184
21 6823 UP Terfenadine [50679-08-8]; Up 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP 3.611E-39 3.869E-36 4.101E-35 8.126E-35 33 152
22 1486 UP Thioridazine hydrochloride [130-61-0]; Up 200; 9.8uM; MCF7; HT HG-U133A Broad Institute CMAP 3.578E-38 3.659E-35 3.878E-34 8.050E-34 33 162
23 5640 UP Digoxigenin [1672-46-4]; Up 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP 1.060E-37 1.037E-34 1.099E-33 2.386E-33 33 167
24 6047 UP Helveticoside [630-64-8]; Up 200; 7.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.312E-37 1.230E-34 1.303E-33 2.951E-33 33 168
25 4983 DN Daunorubicin hydrochloride [23541-50-6]; Down 200; 7uM; MCF7; HT HG-U133A Broad Institute CMAP 2.852E-37 2.567E-34 2.721E-33 6.418E-33 34 190
26 2211 UP Astemizole [68844-77-9]; Up 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP 3.197E-37 2.767E-34 2.933E-33 7.195E-33 32 155
27 1010 UP thioridazine hydrochloride; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 3.999E-37 3.333E-34 3.532E-33 8.998E-33 32 156
28 3295 UP Felodipine [72509-76-3]; Up 200; 10.4uM; MCF7; HT HG-U133A Broad Institute CMAP 5.592E-37 4.494E-34 4.763E-33 1.258E-32 33 175
29 5275 UP Digoxigenin [1672-46-4]; Up 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP 9.625E-37 7.468E-34 7.915E-33 2.166E-32 32 160
30 1937 UP Azacyclonol [115-46-8]; Up 200; 15uM; PC3; HG-U133A Broad Institute CMAP 1.514E-36 1.135E-33 1.203E-32 3.406E-32 33 180
31 3275 UP Digitoxigenin [143-62-4]; Up 200; 10.6uM; MCF7; HT HG-U133A Broad Institute CMAP 2.787E-36 2.023E-33 2.144E-32 6.271E-32 32 165
32 4801 UP Digitoxigenin [143-62-4]; Up 200; 10.6uM; MCF7; HT HG-U133A Broad Institute CMAP 4.220E-36 2.878E-33 3.050E-32 9.497E-32 32 167
33 6680 UP Strophantine octahydrate [11018-89-6]; Up 200; 5.4uM; PC3; HT HG-U133A Broad Institute CMAP 4.220E-36 2.878E-33 3.050E-32 9.497E-32 32 167
34 6048 UP Lanatoside C [17575-22-3]; Up 200; 4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.727E-35 1.143E-32 1.211E-31 3.886E-31 32 174
35 6764 UP Anisomycin [22862-76-6]; Up 200; 15uM; PC3; HT HG-U133A Broad Institute CMAP 2.050E-35 1.318E-32 1.397E-31 4.614E-31 31 157
36 1477 UP Miconazole [22916-47-8]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP 5.494E-35 3.434E-32 3.639E-31 1.236E-30 32 180
37 7340 UP Proscillaridin A [466-06-8]; Up 200; 7.6uM; MCF7; HT HG-U133A Broad Institute CMAP 5.842E-35 3.553E-32 3.766E-31 1.315E-30 31 162
38 5963 DN H-7 dihydrochloride; Down 200; 100uM; MCF7; HT HG-U133A Broad Institute CMAP 6.634E-35 3.928E-32 4.164E-31 1.493E-30 32 181
39 3283 UP Digoxin [20830-75-5]; Up 200; 5.2uM; MCF7; HT HG-U133A Broad Institute CMAP 1.315E-34 7.588E-32 8.042E-31 2.959E-30 31 166
40 6807 UP Astemizole [68844-77-9]; Up 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP 2.824E-34 1.589E-31 1.684E-30 6.355E-30 30 152
41 4680 UP Digoxigenin [1672-46-4]; Up 200; 10.2uM; PC3; HT HG-U133A Broad Institute CMAP 2.896E-34 1.589E-31 1.685E-30 6.516E-30 31 170
42 1068 UP thioridazine hydrochloride; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 5.313E-34 2.847E-31 3.017E-30 1.196E-29 30 155
43 4404 UP Proscillaridin A [466-06-8]; Up 200; 7.6uM; MCF7; HT HG-U133A Broad Institute CMAP 1.478E-33 7.733E-31 8.195E-30 3.325E-29 30 160
44 3887 UP Camptothecine (S,+) [7689-03-4]; Up 200; 11.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.588E-33 8.119E-31 8.605E-30 3.572E-29 31 179
45 5354 DN Mitoxantrone dihydrochloride [70476-82-3]; Down 200; 7.8uM; MCF7; HT HG-U133A Broad Institute CMAP 2.740E-33 1.370E-30 1.452E-29 6.165E-29 31 182
46 3852 UP Lanatoside C [17575-22-3]; Up 200; 4uM; MCF7; HT HG-U133A Broad Institute CMAP 3.264E-33 1.596E-30 1.692E-29 7.344E-29 30 164
47 4713 DN 0175029-0000 [211245-78-2]; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 3.920E-33 1.859E-30 1.970E-29 8.820E-29 31 184
48 3851 UP Helveticoside [630-64-8]; Up 200; 7.4uM; MCF7; HT HG-U133A Broad Institute CMAP 3.965E-33 1.859E-30 1.970E-29 8.922E-29 30 165
49 6087 UP Strophanthidin [66-28-4]; Up 200; 9.8uM; MCF7; HT HG-U133A Broad Institute CMAP 7.053E-33 3.239E-30 3.433E-29 1.587E-28 30 168
50 3945 UP Helveticoside [630-64-8]; Up 200; 7.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.029E-32 4.630E-30 4.908E-29 2.315E-28 30 170
Show 45 more annotations

18: Disease [Display Chart] 2323 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0151744 Myocardial Ischemia DisGeNET Curated 2.504E-15 5.817E-12 4.844E-11 5.817E-12 27 413
2 umls:C1512409 Hepatocarcinogenesis DisGeNET BeFree 2.133E-11 1.942E-8 1.617E-7 4.955E-8 24 471
3 umls:C0333186 Restenosis DisGeNET BeFree 2.507E-11 1.942E-8 1.617E-7 5.825E-8 16 184
4 umls:C0007115 Malignant neoplasm of thyroid DisGeNET BeFree 6.264E-11 3.638E-8 3.030E-7 1.455E-7 23 453
5 umls:C0024115 Lung diseases DisGeNET Curated 1.198E-10 5.568E-8 4.637E-7 2.784E-7 19 307
6 umls:C0206180 Ki-1+ Anaplastic Large Cell Lymphoma DisGeNET Curated 3.023E-10 1.170E-7 9.746E-7 7.021E-7 17 251
7 umls:C3495559 Juvenile arthritis DisGeNET Curated 4.071E-10 1.351E-7 1.125E-6 9.456E-7 18 292
8 umls:C0042373 Vascular Diseases DisGeNET Curated 9.037E-10 2.624E-7 2.185E-6 2.099E-6 19 346
9 umls:C0023470 Myeloid Leukemia DisGeNET Curated 2.869E-9 7.406E-7 6.168E-6 6.665E-6 21 458
10 umls:C0403416 Idiopathic crescentic glomerulonephritis DisGeNET BeFree 4.386E-9 1.019E-6 8.486E-6 1.019E-5 8 41
11 umls:C0020456 Hyperglycemia DisGeNET Curated 9.811E-9 2.072E-6 1.726E-5 2.279E-5 19 400
12 umls:C0003486 Aortic Aneurysm DisGeNET Curated 1.231E-8 2.383E-6 1.985E-5 2.860E-5 14 207
13 umls:C0014335 Enteritis DisGeNET Curated 1.419E-8 2.536E-6 2.112E-5 3.297E-5 7 31
14 umls:C0023267 Fibroid Tumor DisGeNET Curated 1.692E-8 2.808E-6 2.339E-5 3.931E-5 16 287
15 umls:C0243026 Sepsis DisGeNET Curated 5.018E-8 7.771E-6 6.472E-5 1.166E-4 19 443
16 umls:C0016057 Fibrosarcoma DisGeNET Curated 8.350E-8 1.212E-5 1.010E-4 1.940E-4 14 241
17 umls:C0042133 Uterine Fibroids DisGeNET Curated 9.136E-8 1.248E-5 1.040E-4 2.122E-4 16 324
18 umls:C0205788 Histiocytoid hemangioma DisGeNET BeFree 1.206E-7 1.557E-5 1.296E-4 2.802E-4 4 6
19 umls:C1519670 Tumor Angiogenesis DisGeNET BeFree 2.585E-7 3.161E-5 2.632E-4 6.005E-4 18 443
20 umls:C0917798 Cerebral Ischemia DisGeNET BeFree 2.810E-7 3.264E-5 2.719E-4 6.529E-4 12 189
21 umls:C0041696 Unipolar Depression DisGeNET BeFree 3.614E-7 3.997E-5 3.329E-4 8.394E-4 17 405
22 umls:C0036690 Septicemia DisGeNET BeFree 8.677E-7 9.162E-5 7.630E-4 2.016E-3 16 383
23 umls:C1269683 Major Depressive Disorder DisGeNET Curated 1.006E-6 1.016E-4 8.463E-4 2.337E-3 17 436
24 umls:C0013537 Eclampsia DisGeNET BeFree 1.108E-6 1.072E-4 8.931E-4 2.574E-3 11 177
25 umls:C0024668 Mammary Neoplasms, Experimental DisGeNET Curated 2.071E-6 1.925E-4 1.603E-3 4.812E-3 10 152
26 umls:C0238462 Medullary carcinoma of thyroid DisGeNET Curated 3.003E-6 2.639E-4 2.198E-3 6.976E-3 11 196
27 umls:C0040128 Thyroid Diseases DisGeNET Curated 3.068E-6 2.639E-4 2.198E-3 7.126E-3 8 93
28 umls:C0036472 Scrub Typhus DisGeNET BeFree 3.473E-6 2.881E-4 2.400E-3 8.068E-3 5 25
29 umls:C0007095 Carcinoid Tumor DisGeNET BeFree 3.679E-6 2.947E-4 2.454E-3 8.546E-3 10 162
30 umls:C2363142 T-Cell Prolymphocytic Leukemia DisGeNET Curated 4.267E-6 3.207E-4 2.671E-3 9.912E-3 5 26
31 umls:C1621958 Glioblastoma Multiforme DisGeNET BeFree 4.379E-6 3.207E-4 2.671E-3 1.017E-2 16 434
32 umls:C0002895 Anemia, Sickle Cell DisGeNET Curated 4.417E-6 3.207E-4 2.671E-3 1.026E-2 11 204
33 umls:C0034067 Pulmonary Emphysema DisGeNET Curated 6.952E-6 4.850E-4 4.039E-3 1.615E-2 10 174
34 umls:C0162820 Dermatitis, Allergic Contact DisGeNET Curated 7.098E-6 4.850E-4 4.039E-3 1.649E-2 8 104
35 umls:C0024667 Animal Mammary Neoplasms DisGeNET Curated 7.313E-6 4.854E-4 4.042E-3 1.699E-2 9 138
36 umls:C0085119 Foot Ulcer DisGeNET BeFree 8.550E-6 5.301E-4 4.415E-3 1.986E-2 3 5
37 umls:C0278996 Cancer of Head and Neck DisGeNET BeFree 8.636E-6 5.301E-4 4.415E-3 2.006E-2 15 406
38 umls:C0409974 Lupus Erythematosus DisGeNET BeFree 8.672E-6 5.301E-4 4.415E-3 2.014E-2 13 308
39 umls:C0023493 Adult T-Cell Lymphoma/Leukemia DisGeNET Curated 9.366E-6 5.499E-4 4.580E-3 2.176E-2 16 461
40 umls:C0007785 Cerebral Infarction DisGeNET Curated 9.640E-6 5.499E-4 4.580E-3 2.239E-2 12 265
41 umls:C0153381 Malignant neoplasm of mouth DisGeNET BeFree 9.706E-6 5.499E-4 4.580E-3 2.255E-2 15 410
42 umls:C0003507 Aortic Valve Stenosis DisGeNET BeFree 1.157E-5 6.400E-4 5.330E-3 2.688E-2 7 80
43 umls:C0018790 Cardiac Arrest DisGeNET Curated 1.220E-5 6.592E-4 5.490E-3 2.835E-2 9 147
44 umls:C1516170 Cancer Cell Growth DisGeNET BeFree 1.304E-5 6.672E-4 5.556E-3 3.029E-2 13 320
45 umls:C0400966 Non-alcoholic Fatty Liver Disease DisGeNET Curated 1.348E-5 6.672E-4 5.556E-3 3.132E-2 12 274
46 umls:C0374997 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site DisGeNET BeFree 1.393E-5 6.672E-4 5.556E-3 3.236E-2 13 322
47 umls:C2349952 Oropharyngeal Carcinoma DisGeNET BeFree 1.395E-5 6.672E-4 5.556E-3 3.240E-2 6 55
48 umls:C1841972 Glucocorticoid Receptor Deficiency DisGeNET Curated 1.395E-5 6.672E-4 5.556E-3 3.240E-2 6 55
49 umls:C0002793 Anaplasia DisGeNET Curated 1.435E-5 6.672E-4 5.556E-3 3.334E-2 11 231
50 umls:C1800706 Idiopathic Pulmonary Fibrosis DisGeNET Curated 1.440E-5 6.672E-4 5.556E-3 3.344E-2 13 323
Show 45 more annotations