Toppgene analysis for aggregated_1964_log, IC13, negative side

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1: GO: Molecular Function [Display Chart] 198 annotations before applied cutoff / 18819 genes in category

No results to display

2: GO: Biological Process [Display Chart] 1612 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0010810 regulation of cell-substrate adhesion 9.619E-6 1.551E-2
1.235E-1
1.551E-2 6 186
2 GO:0097581 lamellipodium organization 4.947E-5 3.988E-2
3.175E-1
7.975E-2
4 76

3: GO: Cellular Component [Display Chart] 193 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005901 caveola 1.329E-4 1.135E-2
6.631E-2
2.566E-2 4 96
2 GO:0044853 plasma membrane raft 1.879E-4 1.135E-2
6.631E-2
3.626E-2 4 105
3 GO:0043209 myelin sheath 2.248E-4 1.135E-2
6.631E-2
4.340E-2 5 204
4 GO:0098858 actin-based cell projection 2.352E-4 1.135E-2
6.631E-2
4.540E-2 5 206
5 GO:0016600 flotillin complex 3.907E-4 1.508E-2
8.811E-2
7.540E-2
2 11
6 GO:0031594 neuromuscular junction 6.061E-4 1.950E-2
1.139E-1
1.170E-1
3 61
7 GO:0005911 cell-cell junction 9.264E-4 2.554E-2
1.492E-1
1.788E-1
6 420
8 GO:0031012 extracellular matrix 1.233E-3 2.975E-2
1.738E-1
2.380E-1
6 444
9 GO:0030426 growth cone 1.491E-3 3.113E-2
1.819E-1
2.877E-1
4 182
10 GO:0030427 site of polarized growth 1.647E-3 3.113E-2
1.819E-1
3.178E-1
4 187
11 GO:0005912 adherens junction 1.911E-3 3.113E-2
1.819E-1
3.688E-1
6 484
12 GO:0045121 membrane raft 2.323E-3 3.113E-2
1.819E-1
4.484E-1
5 343
13 GO:0098857 membrane microdomain 2.323E-3 3.113E-2
1.819E-1
4.484E-1
5 343
14 GO:0016605 PML body 2.528E-3 3.113E-2
1.819E-1
4.880E-1
3 100
15 GO:0030175 filopodium 2.674E-3 3.113E-2
1.819E-1
5.162E-1
3 102
16 GO:0042642 actomyosin, myosin complex part 2.712E-3 3.113E-2
1.819E-1
5.235E-1
1 1
17 GO:0048770 pigment granule 2.903E-3 3.113E-2
1.819E-1
5.603E-1
3 105
18 GO:0042470 melanosome 2.903E-3 3.113E-2
1.819E-1
5.603E-1
3 105
19 GO:0014069 postsynaptic density 3.931E-3 3.650E-2
2.132E-1
7.588E-1
4 238
20 GO:0099572 postsynaptic specialization 3.931E-3 3.650E-2
2.132E-1
7.588E-1
4 238
21 GO:0031252 cell leading edge 3.984E-3 3.650E-2
2.132E-1
7.689E-1
5 389
22 GO:0005925 focal adhesion 4.160E-3 3.650E-2
2.132E-1
8.029E-1
5 393
23 GO:0005924 cell-substrate adherens junction 4.388E-3 3.682E-2
2.151E-1
8.469E-1
5 398
24 GO:0030055 cell-substrate junction 4.625E-3 3.719E-2
2.173E-1
8.927E-1
5 403
25 GO:0060076 excitatory synapse 5.228E-3 4.021E-2
2.349E-1
1.000E0
4 258
26 GO:0060187 cell pole 5.417E-3 4.021E-2
2.349E-1
1.000E0
1 2
Show 21 more annotations

4: Human Phenotype [Display Chart] 222 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0002599 Head titubation 1.195E-4 2.469E-2
1.477E-1
2.654E-2 2 6
2 HP:0007266 Cerebral dysmyelination 2.224E-4 2.469E-2
1.477E-1
4.938E-2 2 8
3 HP:0002015 Dysphagia 1.085E-3 4.363E-2
2.610E-1
2.409E-1
4 167
4 HP:0011940 Anterior wedging of T12 2.948E-3 4.363E-2
2.610E-1
6.544E-1
1 1
5 HP:0003988 Long ulna 2.948E-3 4.363E-2
2.610E-1
6.544E-1
1 1
6 HP:0012275 Autosomal dominant inheritance with maternal imprinting 2.948E-3 4.363E-2
2.610E-1
6.544E-1
1 1
7 HP:0003789 Minicore myopathy 2.948E-3 4.363E-2
2.610E-1
6.544E-1
1 1
8 HP:0100709 Reduction of oligodendroglia 2.948E-3 4.363E-2
2.610E-1
6.544E-1
1 1
9 HP:0011813 Increased cerebral lipofuscin 2.948E-3 4.363E-2
2.610E-1
6.544E-1
1 1
10 HP:0005066 Cone-shaped epiphyses fused within their metaphyses 2.948E-3 4.363E-2
2.610E-1
6.544E-1
1 1
11 HP:0004573 Anterior wedging of T11 2.948E-3 4.363E-2
2.610E-1
6.544E-1
1 1
12 HP:0004886 Congenital laryngeal stridor 2.948E-3 4.363E-2
2.610E-1
6.544E-1
1 1
13 HP:0008041 Late onset congenital glaucoma 2.948E-3 4.363E-2
2.610E-1
6.544E-1
1 1
14 HP:0004981 Prominent styloid process of ulna 2.948E-3 4.363E-2
2.610E-1
6.544E-1
1 1
15 HP:0006371 Broad long bone diaphyses 2.948E-3 4.363E-2
2.610E-1
6.544E-1
1 1
Show 10 more annotations

5: Mouse Phenotype [Display Chart] 1171 annotations before applied cutoff / 9299 genes in category

No results to display

6: Domain [Display Chart] 460 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF15040 Humanin Pfam 3.224E-4 3.516E-2
2.359E-1
1.483E-1
2 10
2 IPR028139 Humanin InterPro 3.224E-4 3.516E-2
2.359E-1
1.483E-1
2 10
3 PS50026 EGF 3 PROSITE 4.454E-4 3.516E-2
2.359E-1
2.049E-1
5 236
4 PS00022 EGF 1 PROSITE 6.443E-4 3.516E-2
2.359E-1
2.964E-1
5 256
5 PS01186 EGF 2 PROSITE 7.658E-4 3.516E-2
2.359E-1
3.523E-1
5 266
6 IPR008814 Swp1 InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
7 IPR017155 Hist-Lys N-MeTrfase SET InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
8 IPR003829 Pirin N dom InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
9 PS51577 SAM MT43 SET7 PROSITE 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
10 IPR027695 Keratin-18 InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
11 IPR015656 MAP1A InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
12 IPR030297 UCHL1 InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
13 IPR028547 Biglycan InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
14 IPR032971 CYP1B1 InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
15 IPR033596 ADAM19 InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
16 PS00492 CLUSTERIN 1 PROSITE 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
17 PF05881 CNPase Pfam 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
18 PS00493 CLUSTERIN 2 PROSITE 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
19 PF05817 Ribophorin II Pfam 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
20 IPR031076 HMGB1 InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
21 IPR027690 Ten2 InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
22 IPR028448 ABLIM1 InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
23 IPR029978 LMO-7 InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
24 IPR028788 CDK6 InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
25 PF02678 Pirin Pfam 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
26 PF05726 Pirin C Pfam 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
27 IPR008778 Pirin C dom InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
28 IPR008431 CNPase InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
29 IPR033216 CDH13 InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
30 IPR027333 CORO1C InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
31 IPR012093 Pirin InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
32 IPR031230 OLFML3 InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
33 IPR028720 HEG InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
34 IPR016016 Clusterin InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
35 IPR030799 LRP4 InterPro 2.722E-3 3.516E-2
2.359E-1
1.000E0
1 1
36 SM00179 EGF CA SMART 4.468E-3 3.516E-2
2.359E-1
1.000E0
3 122
37 IPR001881 EGF-like Ca-bd dom InterPro 4.676E-3 3.516E-2
2.359E-1
1.000E0
3 124
38 IPR000742 EGF-like dom InterPro 4.732E-3 3.516E-2
2.359E-1
1.000E0
4 250
39 2.120.10.30 - Gene3D 5.048E-3 3.516E-2
2.359E-1
1.000E0
2 39
40 IPR026179 Slain InterPro 5.437E-3 3.516E-2
2.359E-1
1.000E0
1 2
41 PF01093 Clusterin Pfam 5.437E-3 3.516E-2
2.359E-1
1.000E0
1 2
42 IPR005786 B amino transII InterPro 5.437E-3 3.516E-2
2.359E-1
1.000E0
1 2
43 IPR021165 Saposin chordata InterPro 5.437E-3 3.516E-2
2.359E-1
1.000E0
1 2
44 IPR031865 DUF4757 InterPro 5.437E-3 3.516E-2
2.359E-1
1.000E0
1 2
45 PF15949 DUF4757 Pfam 5.437E-3 3.516E-2
2.359E-1
1.000E0
1 2
46 IPR000753 Clusterin-like InterPro 5.437E-3 3.516E-2
2.359E-1
1.000E0
1 2
47 IPR026995 Astrotactin InterPro 5.437E-3 3.516E-2
2.359E-1
1.000E0
1 2
48 PF02887 PK C Pfam 5.437E-3 3.516E-2
2.359E-1
1.000E0
1 2
49 2.40.33.10 - Gene3D 5.437E-3 3.516E-2
2.359E-1
1.000E0
1 2
50 IPR015794 Pyrv Knase a/b InterPro 5.437E-3 3.516E-2
2.359E-1
1.000E0
1 2
Show 45 more annotations

7: Pathway [Display Chart] 332 annotations before applied cutoff / 10916 genes in category

No results to display

8: Pubmed [Display Chart] 11187 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20936779 A human MAP kinase interactome. Pubmed 4.010E-8 4.486E-4 4.441E-3 4.486E-4 8 486
2 14647468 Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression. Pubmed 1.064E-6 2.382E-3 2.358E-2 1.191E-2 2 2
3 14596919:gr Dab2 links CIN85 with clathrin-mediated receptor internalization. GeneRIF 1.064E-6 2.382E-3 2.358E-2 1.191E-2 2 2
4 14647468:gr Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression. GeneRIF 1.064E-6 2.382E-3 2.358E-2 1.191E-2 2 2
5 23692925:gr Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. GeneRIF 1.064E-6 2.382E-3 2.358E-2 1.191E-2 2 2
6 25640309 Systematic identification of molecular links between core and candidate genes in breast cancer. Pubmed 1.897E-6 2.616E-3 2.589E-2 2.122E-2 5 194
7 21472765:gr Expression of myelin genes: comparative analysis of Oli-neu and N20.1 oligodendroglial cell lines. GeneRIF 3.191E-6 2.616E-3 2.589E-2 3.570E-2 2 3
8 17496311:gr Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers. GeneRIF 3.191E-6 2.616E-3 2.589E-2 3.570E-2 2 3
9 17496311 Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers. Pubmed 3.191E-6 2.616E-3 2.589E-2 3.570E-2 2 3
10 19138946 Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-10F cells. Pubmed 3.191E-6 2.616E-3 2.589E-2 3.570E-2 2 3
11 19138946:gr Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-10F cells. GeneRIF 3.191E-6 2.616E-3 2.589E-2 3.570E-2 2 3
12 20000738 Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma. Pubmed 4.137E-6 2.616E-3 2.589E-2 4.628E-2 4 102
13 18839057:gr Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. GeneRIF 6.378E-6 2.616E-3 2.589E-2
7.135E-2
2 4
14 25930075 Oligodendrocyte morphometry and expression of myelin - Related mRNA in ventral prefrontal white matter in major depressive disorder. Pubmed 6.378E-6 2.616E-3 2.589E-2
7.135E-2
2 4
15 15808404:gr Genetic polymorphisms in CYP1B1, GSTA1, NQO1 and NAT2 and the risk of lung cancer. GeneRIF 6.378E-6 2.616E-3 2.589E-2
7.135E-2
2 4
16 19502044:gr Role of genetic susceptibility to latent adenoviral infection and decreased lung function. GeneRIF 6.378E-6 2.616E-3 2.589E-2
7.135E-2
2 4
17 19502044 Role of genetic susceptibility to latent adenoviral infection and decreased lung function. Pubmed 6.378E-6 2.616E-3 2.589E-2
7.135E-2
2 4
18 15808404 Genetic polymorphisms in CYP1B1, GSTA1, NQO1 and NAT2 and the risk of lung cancer. Pubmed 6.378E-6 2.616E-3 2.589E-2
7.135E-2
2 4
19 20027111:gr Review of studies on metabolic genes and cancer in populations of African descent. GeneRIF 1.062E-5 2.616E-3 2.589E-2
1.188E-1
2 5
20 16598069 Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors. Pubmed 1.062E-5 2.616E-3 2.589E-2
1.188E-1
2 5
21 20027111 Review of studies on metabolic genes and cancer in populations of African descent. Pubmed 1.062E-5 2.616E-3 2.589E-2
1.188E-1
2 5
22 14596919 Dab2 links CIN85 with clathrin-mediated receptor internalization. Pubmed 1.062E-5 2.616E-3 2.589E-2
1.188E-1
2 5
23 16598069:gr Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors. GeneRIF 1.062E-5 2.616E-3 2.589E-2
1.188E-1
2 5
24 20878130:gr Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population. GeneRIF 1.592E-5 2.616E-3 2.589E-2
1.781E-1
2 6
25 19736056 Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma. Pubmed 1.592E-5 2.616E-3 2.589E-2
1.781E-1
2 6
26 20878130 Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population. Pubmed 1.592E-5 2.616E-3 2.589E-2
1.781E-1
2 6
27 19736056:gr Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma. GeneRIF 1.592E-5 2.616E-3 2.589E-2
1.781E-1
2 6
28 23398456 The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. Pubmed 2.409E-5 2.616E-3 2.589E-2
2.695E-1
5 328
29 15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Pubmed 2.703E-5 2.616E-3 2.589E-2
3.024E-1
5 336
30 24332808 PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Pubmed 2.860E-5 2.616E-3 2.589E-2
3.199E-1
5 340
31 19079262:gr New sequence variants associated with bone mineral density. GeneRIF 2.969E-5 2.616E-3 2.589E-2
3.321E-1
2 8
32 12837283:gr Senescence-associated genes in normal human oral keratinocytes. GeneRIF 2.969E-5 2.616E-3 2.589E-2
3.321E-1
2 8
33 21555518 The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. Pubmed 3.503E-5 2.616E-3 2.589E-2
3.918E-1
3 60
34 21555518:gr The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. GeneRIF 3.503E-5 2.616E-3 2.589E-2
3.918E-1
3 60
35 12837283 Senescence-associated genes in normal human oral keratinocytes. Pubmed 3.814E-5 2.616E-3 2.589E-2
4.267E-1
2 9
36 20568895 Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central Europe. Pubmed 3.814E-5 2.616E-3 2.589E-2
4.267E-1
2 9
37 19623253 Humanin: a novel central regulator of peripheral insulin action. Pubmed 3.814E-5 2.616E-3 2.589E-2
4.267E-1
2 9
38 20568895:gr Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central Europe. GeneRIF 3.814E-5 2.616E-3 2.589E-2
4.267E-1
2 9
39 20542501 Immunolocalization of humanin in human sperm and testis. Pubmed 3.814E-5 2.616E-3 2.589E-2
4.267E-1
2 9
40 18784359:gr Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population. GeneRIF 4.765E-5 2.616E-3 2.589E-2
5.330E-1
2 10
41 23402768 Humanin: a harbinger of mitochondrial-derived peptides? Pubmed 4.765E-5 2.616E-3 2.589E-2
5.330E-1
2 10
42 19174490 Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. Pubmed 4.765E-5 2.616E-3 2.589E-2
5.330E-1
2 10
43 25630734 The human mitochondrial genome may code for more than 13 proteins. Pubmed 4.765E-5 2.616E-3 2.589E-2
5.330E-1
2 10
44 19174490:gr Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. GeneRIF 4.765E-5 2.616E-3 2.589E-2
5.330E-1
2 10
45 18569591:gr Head and neck squamous-cell cancer and its association with polymorphic enzymes of xenobiotic metabolism and repair. GeneRIF 4.765E-5 2.616E-3 2.589E-2
5.330E-1
2 10
46 18569591 Head and neck squamous-cell cancer and its association with polymorphic enzymes of xenobiotic metabolism and repair. Pubmed 4.765E-5 2.616E-3 2.589E-2
5.330E-1
2 10
47 18784359 Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population. Pubmed 4.765E-5 2.616E-3 2.589E-2
5.330E-1
2 10
48 7566098 Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. Pubmed 4.884E-5 2.616E-3 2.589E-2
5.464E-1
4 191
49 17363580 Association of CYP1B1 germ line mutations with hepatocyte nuclear factor 1alpha-mutated hepatocellular adenoma. Pubmed 5.819E-5 2.616E-3 2.589E-2
6.510E-1
2 11
50 16985026 Metabolic gene variants and risk of non-Hodgkin's lymphoma. Pubmed 5.819E-5 2.616E-3 2.589E-2
6.510E-1
2 11
Show 45 more annotations

9: Interaction [Display Chart] 1472 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:SYNPO SYNPO interactions 4.355E-7 6.411E-4 5.047E-3 6.411E-4 7 154
2 int:CAPZA2 CAPZA2 interactions 8.872E-7 6.529E-4 5.140E-3 1.306E-3 8 250
3 int:ANLN ANLN interactions 5.337E-6 2.618E-3 2.061E-2 7.855E-3 6 145
4 int:MYO18A MYO18A interactions 9.735E-6 3.583E-3 2.820E-2 1.433E-2 6 161
5 int:MYO19 MYO19 interactions 1.373E-5 3.717E-3 2.926E-2 2.021E-2 6 171
6 int:IQGAP1 IQGAP1 interactions 1.515E-5 3.717E-3 2.926E-2 2.230E-2 7 263
7 int:DBN1 DBN1 interactions 5.522E-5 1.161E-2
9.141E-2
8.129E-2
6 219
8 int:PPP1CB PPP1CB interactions 7.074E-5 1.302E-2
1.025E-1
1.041E-1
6 229
9 int:GRHPR GRHPR interactions 1.413E-4 2.311E-2
1.819E-1
2.080E-1
3 33
10 int:PUS1 PUS1 interactions 2.336E-4 3.155E-2
2.483E-1
3.439E-1
3 39
11 int:RUNX1 RUNX1 interactions 2.531E-4 3.155E-2
2.483E-1
3.726E-1
4 100
12 int:LIMA1 LIMA1 interactions 2.572E-4 3.155E-2
2.483E-1
3.786E-1
5 185
13 int:CFL2 CFL2 interactions 3.128E-4 3.522E-2
2.772E-1
4.604E-1
3 43
14 int:TRADD TRADD interactions 3.349E-4 3.522E-2
2.772E-1
4.930E-1
3 44
15 int:MYH9 MYH9 interactions 4.268E-4 4.188E-2
3.297E-1
6.282E-1
6 319
16 int:CBY1 CBY1 interactions 5.040E-4 4.360E-2
3.432E-1
7.419E-1
2 11
17 int:CKMT2 CKMT2 interactions 5.040E-4 4.360E-2
3.432E-1
7.419E-1
2 11
18 int:AGL AGL interactions 5.493E-4 4.360E-2
3.432E-1
8.085E-1
3 52
19 int:RPA1 RPA1 interactions 5.627E-4 4.360E-2
3.432E-1
8.283E-1
7 470
Show 14 more annotations

10: Cytoband [Display Chart] 52 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3q23-q24 3q23-q24 1.529E-3 3.973E-2
1.803E-1
7.951E-2
1 1
2 8p21-p12 8p21-p12 1.529E-3 3.973E-2
1.803E-1
7.951E-2
1 1
3 7q32-q34 7q32-q34 3.056E-3 3.973E-2
1.803E-1
1.589E-1
1 2
4 7p14.3-p14.1 7p14.3-p14.1 3.056E-3 3.973E-2
1.803E-1
1.589E-1
1 2
5 Xp22.1-p21.3 Xp22.1-p21.3 4.580E-3 4.246E-2
1.927E-1
2.382E-1
1 3
6 2q37.1 2q37.1 4.899E-3 4.246E-2
1.927E-1
2.548E-1
2 68
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 267 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 37 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18 Major cadherins genenames.org 3.295E-3 4.051E-2
1.702E-1
1.219E-1
1 2
2 1218 LIM domain containing genenames.org 4.242E-3 4.051E-2
1.702E-1
1.570E-1
2 59
3 1100 Myosins, class V genenames.org 4.939E-3 4.051E-2
1.702E-1
1.827E-1
1 3
4 1000 Cytochrome P450 family 1 genenames.org 6.580E-3 4.051E-2
1.702E-1
2.435E-1
1 4
5 998 Parkinson disease associated genes|Ubiquitin C-terminal hydrolases genenames.org 6.580E-3 4.051E-2
1.702E-1
2.435E-1
1 4
6 623 Ankyrin repeat domain containing|KN motif and ankyrin repeat domain containing genenames.org 6.580E-3 4.051E-2
1.702E-1
2.435E-1
1 4
7 1215 Transmembrane BAX inhibitor motif containing genenames.org 9.854E-3 4.051E-2
1.702E-1
3.646E-1
1 6
8 828 Ferlin family|Deafness associated genes genenames.org 9.854E-3 4.051E-2
1.702E-1
3.646E-1
1 6
9 1225 WD repeat domain containing|UTPB complex genenames.org 9.854E-3 4.051E-2
1.702E-1
3.646E-1
1 6
10 495 WD repeat domain containing|Coronins genenames.org 1.149E-2 4.250E-2
1.786E-1
4.250E-1
1 7
11 1278 SPARC family genenames.org 1.312E-2 4.412E-2
1.854E-1
4.854E-1
1 8
Show 6 more annotations

13: Coexpression [Display Chart] 3791 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M9192 Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.105E-7 2.425E-4 2.138E-3 4.188E-4 10 460
2 M17471 Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS, non-invasive). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.279E-7 2.425E-4 2.138E-3 4.850E-4 9 351
3 M8831 Genes up-regulated in A549 cells (lung cancer) expressing MIRLET7A3 [GeneID=406883] microRNA off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.513E-7 3.176E-4 2.800E-3 9.528E-4 6 111
4 M2698 Genes up-regulated in NCI-60 panel of cell lines with mutated TP53 [Gene ID=7157]. MSigDB C6: Oncogenic Signatures (v5.1) 3.705E-7 3.511E-4 3.096E-3 1.405E-3 7 194
5 M2293 Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.361E-7 5.581E-4 4.921E-3 2.790E-3 8 315
6 M2238 Genes up-regulated upon overexpression of PARVB [GeneID=29780] in MDA-MB-231 cells (breast cancer) cultured in 3D collagen I and 3D Matrigel only. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.882E-7 5.979E-4 5.272E-3 3.746E-3 6 140
7 M14507 Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.104E-6 5.979E-4 5.272E-3 4.185E-3 9 454
8 M19467 Genes down-regulated in five primary endothelial cell types (lung, aortic, iliac, dermal, and colon) by TNF [GeneID=7124]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.355E-6 1.116E-3 9.841E-3 8.929E-3 5 90
9 M17079 Up-regulated genes distinguishing between two subtypes of gastric cancer: advanced (AGC) and early (EGC). MSigDB C2: CGP Curated Gene Sets (v5.1) 3.617E-6 1.524E-3 1.344E-2 1.371E-2 6 175
10 M8544 Up-regualted genes from the set F (Fig. 5a): specific signature shared by cells expressing AF4-MLL [GeneID=4299;4297] alone and those expressing both AF4-MLL and MLL-AF4 fusion proteins. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.982E-6 1.665E-3 1.468E-2 1.889E-2 6 185
11 M18149 Genes up-regulated in peripheral blood monocytes by HGF [GeneID=3082]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.010E-6 1.665E-3 1.468E-2 2.278E-2 8 418
12 M11619 Genes down-regulated in MDA-MB-231 cells (breast cancer) after knockdown of PRKCA and ETS1 [GeneID=5578;2113] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.949E-6 1.665E-3 1.468E-2 2.634E-2 3 16
13 M3296 Genes down-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) 1 day after stimulation with YF17D vaccine versus PBMC 7 days after the stimulation. MSigDB C7: Immunologic Signatures (v5.1) 7.569E-6 1.665E-3 1.468E-2 2.870E-2 6 199
14 M3288 Genes down-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) versus PBMC 7 days after stimulation with YF17D vaccine. MSigDB C7: Immunologic Signatures (v5.1) 7.789E-6 1.665E-3 1.468E-2 2.953E-2 6 200
15 GSE22140 GERMFREE VS SPF MOUSE CD4 TCELL DN Genes down-regulated in healthy CD4 [GeneID=920] T cells: germ free versus specific pathogen free. MSigDB C7: Immunologic Signatures (v5.1) 7.789E-6 1.665E-3 1.468E-2 2.953E-2 6 200
16 GSE21546 UNSTIM VS ANTI CD3 STIM DP THYMOCYTES UP Genes up-regulated in double positive thymocytes: untreated versus stimulated by anti-CD3. MSigDB C7: Immunologic Signatures (v5.1) 7.789E-6 1.665E-3 1.468E-2 2.953E-2 6 200
17 M4624 Genes down-regulated in comparison of untreated CD25+ T effector cells at day 7 versus untreated CD25- T cells at day 7. MSigDB C7: Immunologic Signatures (v5.1) 7.789E-6 1.665E-3 1.468E-2 2.953E-2 6 200
18 M4665 Genes down-regulated in glomeruli of kidneys from patients with diabetic nephropathy (type 2 diabetes mellitus). MSigDB C2: CGP Curated Gene Sets (v5.1) 7.906E-6 1.665E-3 1.468E-2 2.997E-2 8 434
19 M19629 The 'NPM1-mutated signature 1': genes down-regulated in pediatric AML (acute myeloid leukemia) samples with mutated NPM1 [GeneID=4869] compared to all AML cases with the intact gene. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.227E-5 2.448E-3 2.159E-2 4.652E-2 5 126
20 M2446 Genes down-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 10 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.405E-5 4.559E-3 4.020E-2
9.118E-2
6 244
21 M11825 Genes down-regulated in A549 cells (lung cancer) expressing MIRLET7A3 [GeneID=406883] microRNA off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.561E-5 6.176E-3
5.446E-2
1.350E-1
4 78
22 M5547 Age up-regulated genes in the human frontal cortex. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.584E-5 6.176E-3
5.446E-2
1.359E-1
6 262
23 M15047 The 'NPM1 signature 3': genes down-regulated in pediatric AML (acute myeloid leukemia) with mutated NPM1 [GeneID=4869] compared to the AML cases with intact NPM1 and MLL [GeneID=4297]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.116E-5 6.784E-3
5.982E-2
1.560E-1
5 162
24 M19971 Genes up-regulated in peripheral blood mononucleocytes by HGF [GeneID=3082] compared to those regulated by CSF2RB (GM-CSF) and IL4 [GeneID=1437;3565]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.851E-5 7.662E-3
6.757E-2
1.839E-1
7 408
25 M1804 Genes up-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.188E-5 7.867E-3
6.937E-2
1.967E-1
6 280
26 M1674 Genes up-regulated in H460 cells (non-small cell lung carcinoma, NSCLC) after treatment with sodium butyrate [PubChem=5222465]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.439E-5 7.931E-3
6.993E-2
2.062E-1
3 31
27 M18532 Genes positively correlated with amplifications of MYCN [GeneID=4613] in the SCLC (small cell lung cancer) cell lines. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.806E-5 9.556E-3
8.426E-2
2.580E-1
4 92
28 M2001 Genes associated with migration rate of 40 human bladder cancer cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.536E-5 9.839E-3
8.676E-2
2.857E-1
5 184
29 M3645 Genes up-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.134E-5 9.839E-3
8.676E-2
3.084E-1
7 443
30 GSE19941 LPS VS LPS AND IL10 STIM IL10 KO NFKBP50 KO MACROPHAGE UP Genes up-regulated in NFKB1 and IL10 [GeneID=4790;3586] knockout macrophages stimulated by LPS versus those also stimulated by IL10 [GeneID=3586]. MSigDB C7: Immunologic Signatures (v5.1) 1.090E-4 9.839E-3
8.676E-2
4.132E-1
5 199
31 GSE42021 CD24HI VS CD24LOW TREG THYMUS DN Genes down-regulated in thymic T reg: CD24 high [GeneID=100133941] versus CD24 low [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v5.1) 1.116E-4 9.839E-3
8.676E-2
4.231E-1
5 200
32 M4492 Genes down-regulated in comparison of naive CD8 T cells versus unstimulated dendritic cells (DC). MSigDB C7: Immunologic Signatures (v5.1) 1.116E-4 9.839E-3
8.676E-2
4.231E-1
5 200
33 M5206 Genes down-regulated in comparison of dendritic cells (DC) exposed to L. donovani versus DCs exposed to M. tuberculosis. MSigDB C7: Immunologic Signatures (v5.1) 1.116E-4 9.839E-3
8.676E-2
4.231E-1
5 200
34 GSE22140 HEALTHY VS ARTHRITIC GERMFREE MOUSE CD4 TCELL DN Genes down-regulated in CD4 [GeneID=920] T cells under germ free conditions: healthy versus arthritis (KRN model). MSigDB C7: Immunologic Signatures (v5.1) 1.116E-4 9.839E-3
8.676E-2
4.231E-1
5 200
35 M5228 Genes down-regulated in comparison of dendritic cells (DC) exposed to 50 worms/well B. malayi versus DC exposed to M. tuberculosis MSigDB C7: Immunologic Signatures (v5.1) 1.116E-4 9.839E-3
8.676E-2
4.231E-1
5 200
36 M5478 Genes up-regulated in comparison of dendritic cells (DC) versus NK cells. MSigDB C7: Immunologic Signatures (v5.1) 1.116E-4 9.839E-3
8.676E-2
4.231E-1
5 200
37 M5474 Genes up-regulated in comparison of dendritic cells (DC) versus effector memory CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v5.1) 1.116E-4 9.839E-3
8.676E-2
4.231E-1
5 200
38 GSE34006 WT VS A2AR KO TREG DN Genes down-regulated in T reg: wildtype versus ADORA2A [GeneID=135]. MSigDB C7: Immunologic Signatures (v5.1) 1.116E-4 9.839E-3
8.676E-2
4.231E-1
5 200
39 M4476 Genes down-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated dendritic cells (DC). MSigDB C7: Immunologic Signatures (v5.1) 1.116E-4 9.839E-3
8.676E-2
4.231E-1
5 200
40 M6625 Genes up-regulated in bone marrow-derived macrophages with IL6 [GeneID=3469] knockout and 45 min of stimulation by AIL10 [GeneID=3486] and LPS versus IL6 [GeneID=3469] and LPS. MSigDB C7: Immunologic Signatures (v5.1) 1.116E-4 9.839E-3
8.676E-2
4.231E-1
5 200
41 M5590 Genes down-regulated in comparison of central memory CD4 [GeneID=920] T cells versus Th1 cells. MSigDB C7: Immunologic Signatures (v5.1) 1.116E-4 9.839E-3
8.676E-2
4.231E-1
5 200
42 M5909 Genes involved in development of skeletal muscle (myogenesis). MSigDB H: Hallmark Gene Sets (v5.1) 1.116E-4 9.839E-3
8.676E-2
4.231E-1
5 200
43 M5288 Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from young donors versus those treated with TSST at 16 h. MSigDB C7: Immunologic Signatures (v5.1) 1.116E-4 9.839E-3
8.676E-2
4.231E-1
5 200
44 M11504 Genes down-regulated in prostate cancer vs benign prostate tissue, based on a meta-analysis of five gene expression profiling studies. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.178E-4 1.015E-2
8.947E-2
4.464E-1
3 40
45 M1565 Genes up-regulated in MMEC cells (myometrial endothelium) by VEGFA [GeneID=7422] stimulation. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.269E-4 1.069E-2
9.428E-2
4.812E-1
4 108
46 M19391 Genes down-regulated in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.339E-4 1.103E-2
9.728E-2
5.075E-1
7 480
47 M1240 Genes down-regulated in early vs late brain tumors induced by retroviral delivery of PDGFB [GeneID=5155]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.677E-4 1.353E-2
1.193E-1
6.358E-1
3 45
48 M4716 Genes up-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402], a protease inhibitor causing apoptosis. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.558E-4 2.020E-2
1.781E-1
9.696E-1
5 239
49 M18085 Genes up-regulated in T24 cells (bladder carcinoma) after treatment with decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.732E-4 2.080E-2
1.834E-1
1.000E0
3 53
50 M1687 Proteins secreted in co-culture of LKR-13 tumor cells (non-small cell lung cancer, NSCLC) and MLg stroma cells (fibroblasts). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.744E-4 2.080E-2
1.834E-1
1.000E0
4 132
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 1999 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.729E-8 1.345E-4 1.100E-3 1.345E-4 10 410
2 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k2 1000 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 9.828E-7 7.924E-4 6.480E-3 1.965E-3 7 211
3 gudmap kidney adult RenalCapsule k4 1000 kidney adult RenalCapsule k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.189E-6 7.924E-4 6.480E-3 2.377E-3 6 136
4 gudmap kidney e15.5 Podocyte MafB k2 1000 kidney e15.5 Podocyte MafB k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.172E-6 1.463E-3 1.196E-2 6.341E-3 5 90
5 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 3.659E-6 1.463E-3 1.196E-2 7.315E-3 9 494
6 PCBC ratio ECTO blastocyst vs ECTO UCB CD34+Z cfr-2X-p05 ECTO blastocyst vs ECTO UCB CD34+Z-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 8.788E-6 2.928E-3 2.394E-2 1.757E-2 7 294
7 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k2 500 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.102E-5 3.146E-3 2.573E-2 2.202E-2 5 116
8 gudmap kidney P4 CapMesRenVes Crym k1 1000 kidney P4 CapMesRenVes Crym k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.194E-5 5.483E-3 4.484E-2 4.387E-2 4 65
9 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 3.217E-5 6.618E-3
5.412E-2
6.431E-2
8 496
10 oligodendrocytes Top 500 All oligodendrocytes Top 500 All Brain Map - Barres 3.311E-5 6.618E-3
5.412E-2
6.618E-2
8 498
11 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma 500 dev gonad e13.5 F VascAssocMesenchStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.055E-5 6.987E-3
5.714E-2
8.105E-2
7 373
12 gudmap developingKidney e15.5 cortic collect duct 1000 k4 DevelopingKidney e15.5 cortic collect duct emap-28132 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.194E-5 6.987E-3
5.714E-2
8.385E-2
7 375
13 gudmap developingGonad P2 ovary 500 DevelopingGonad P2 ovary emap-30224 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.561E-5 7.014E-3
5.736E-2
9.118E-2
7 380
14 26Dp SubClass 26Dp 4 Top 500 Cluster 1 26Dp SubClass 26Dp 4 Top 500 Cluster 1 Brain Map - Allen iN 5.314E-5 7.588E-3
6.205E-2
1.062E-1
3 29
15 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary Sma k4 1000 dev gonad e13.5 F VascAssocMesenchStromOvary Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 6.533E-5 8.142E-3
6.659E-2
1.306E-1
5 168
16 endothelial SubClass endothelial all Top 500 Cluster 3 endothelial SubClass endothelial all Top 500 Cluster 3 Brain Map - Barres 6.618E-5 8.142E-3
6.659E-2
1.323E-1
4 86
17 gudmap kidney adult GlomCapSys Tie2 k3 500 kidney adult GlomCapSys Tie2 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.924E-5 8.142E-3
6.659E-2
1.384E-1
4 87
18 GSM777059 100 Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 8.253E-5 9.165E-3
7.495E-2
1.650E-1
4 91
19 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 500 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.942E-5 9.408E-3
7.694E-2
1.787E-1
7 423
20 PCBC ratio DE blastocyst vs DE cord blood cfr-2X-p05 DE blastocyst vs DE cord blood-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.016E-4 9.673E-3
7.911E-2
2.031E-1
4 96
21 GSM777063 100 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.016E-4 9.673E-3
7.911E-2
2.031E-1
4 96
22 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 500 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.159E-4 1.021E-2
8.346E-2
2.316E-1
7 441
23 12Dp Top 500 Cluster 4 12Dp Top 500 Cluster 4 Brain Map - Allen iN 1.207E-4 1.021E-2
8.346E-2
2.414E-1
3 38
24 gudmap kidney adult Podocyte MafB 500 kidney adult Podocyte MafB top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.225E-4 1.021E-2
8.346E-2
2.449E-1
7 445
25 GSM777063 500 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.313E-4 1.050E-2
8.585E-2
2.624E-1
7 450
26 ratio EB vs SC 2500 K5 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 2500 k-means-cluster#5 PCBC 1.387E-4 1.067E-2
8.722E-2
2.773E-1
6 315
27 JC fibro 1000 K1 JC fibro top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 1.586E-4 1.174E-2
9.602E-2
3.170E-1
7 464
28 80Dn Top 500 Cluster 0 80Dn Top 500 Cluster 0 Brain Map - Allen iN 1.875E-4 1.339E-2
1.095E-1
3.749E-1
3 44
29 gudmap kidney P3 CapMes Crym k2 1000 kidney P3 CapMes Crym k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.974E-4 1.361E-2
1.113E-1
3.946E-1
4 114
30 12Dp Top 500 All 12Dp Top 500 All Brain Map - Allen iN 2.106E-4 1.404E-2
1.148E-1
4.211E-1
7 486
31 Facebase RNAseq e8.5 Non-Floor Plate Neural Epithelium 500 FacebaseRNAseq e8.5 Non-Floor Plate Neural Epithelium top-relative-expression-ranked 500 FaceBase_RNAseq 2.187E-4 1.410E-2
1.153E-1
4.372E-1
7 489
32 OPC Top 500 All OPC Top 500 All Brain Map - Barres 2.327E-4 1.427E-2
1.167E-1
4.652E-1
7 494
33 Facebase RNAseq e10.5 Olfactory Pit 500 FacebaseRNAseq e10.5 Olfactory Pit top-relative-expression-ranked 500 FaceBase_RNAseq 2.356E-4 1.427E-2
1.167E-1
4.709E-1
7 495
34 gudmap dev gonad e12.5 F VasAssocMesStromOvary Sma k4 1000 dev gonad e12.5 F VasAssocMesStromOvary Sma k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.809E-4 1.617E-2
1.323E-1
5.615E-1
4 125
35 54Dn Top 500 Cluster 4 54Dn Top 500 Cluster 4 Brain Map - Allen iN 2.895E-4 1.617E-2
1.323E-1
5.788E-1
4 126
36 gudmap dev gonad e13.5 M InterstitTestis Sma 500 dev gonad e13.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.938E-4 1.617E-2
1.323E-1
5.873E-1
6 362
37 GSM791102 500 Stem Cells, SC.LT34F.BM, Lineage- cKit+ Sca-1+ flk2- CD34-, Bone marrow, avg-3 Immgen.org, GSE15907 3.070E-4 1.617E-2
1.323E-1
6.137E-1
6 365
38 endothelial Top 500 Cluster 0 endothelial Top 500 Cluster 0 Brain Map - Barres 3.075E-4 1.617E-2
1.323E-1
6.146E-1
4 128
39 gudmap dev gonad e12.5 M InterstitTestis Sma 500 dev gonad e12.5 M InterstitTestis Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.496E-4 1.792E-2
1.465E-1
6.988E-1
6 374
40 gudmap developingKidney e15.5 1000 k3 DevelopingKidney e15.5 anlage of loop of Henle emap-31283 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.752E-4 1.875E-2
1.533E-1
7.500E-1
6 379
41 Facebase RNAseq ratio e10.5 MandibularArch vs MaxillaryArch 2500 K1 FacebaseRNAseq ratio e10.5 MandibularArch vs MaxillaryArch top-relative-expression-ranked 2500 k-means-cluster#1 FaceBase_RNAseq 4.078E-4 1.947E-2
1.593E-1
8.152E-1
6 385
42 gudmap dev gonad e12.5 M InterstitLeydig MafB 200 dev gonad e12.5 M InterstitLeydig MafB top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 4.092E-4 1.947E-2
1.593E-1
8.179E-1
4 138
43 gudmap developingLowerUrinaryTract P2 bladder urothelium (LCM) 500 DevelopingLowerUrinaryTract P2 bladder urothelium (LCM) emap-30380 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.426E-4 2.020E-2
1.652E-1
8.847E-1
6 391
44 gudmap dev gonad e12.5 M InterstitLeydig MafB k2 200 dev gonad e12.5 M InterstitLeydig MafB k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 4.482E-4 2.020E-2
1.652E-1
8.959E-1
3 59
45 gudmap developingLowerUrinaryTract e13.5 bladder epithelial cells 500 DevelopingLowerUrinaryTract e13.5 bladder epithelial cells emap-30875 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.547E-4 2.020E-2
1.652E-1
9.089E-1
6 393
46 gudmap kidney adult Mesangium Meis k4 1000 kidney adult Mesangium Meis k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.802E-4 2.044E-2
1.672E-1
9.599E-1
5 258
47 Facebase RNAseq e10.5 Olfactory Pit 500 K3 FacebaseRNAseq e10.5 Olfactory Pit top-relative-expression-ranked 500 k-means-cluster#3 FaceBase_RNAseq 4.806E-4 2.044E-2
1.672E-1
9.607E-1
4 144
48 gudmap kidney P4 CapMesRenVes Crym 500 kidney P4 CapMesRenVes Crym top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.925E-4 2.051E-2
1.677E-1
9.845E-1
6 399
49 gudmap dev gonad e13.5 M InterstitFLeydig MafB 200 dev gonad e13.5 M InterstitFLeydig MafB top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 5.063E-4 2.065E-2
1.689E-1
1.000E0
4 146
50 gudmap dev gonad e13.5 M InterstitTestis Sma 200 dev gonad e13.5 M InterstitTestis Sma top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 5.329E-4 2.107E-2
1.723E-1
1.000E0
4 148
Show 45 more annotations

15: Computational [Display Chart] 218 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GCM MAPK10 Neighborhood of MAPK10 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.501E-4 2.572E-2
1.534E-1
7.632E-2
4 76
2 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 3.611E-4 2.572E-2
1.534E-1
7.871E-2
6 216
3 module 44 Genes in module 44 MSigDb: C4 - CM: Cancer Modules 4.709E-4 2.572E-2
1.534E-1
1.027E-1
7 319
4 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 4.822E-4 2.572E-2
1.534E-1
1.051E-1
8 423
5 module 18 Genes in module 18 MSigDb: C4 - CM: Cancer Modules 5.898E-4 2.572E-2
1.534E-1
1.286E-1
8 436
6 module 128 Genes in module 128 MSigDb: C4 - CM: Cancer Modules 9.181E-4 2.698E-2
1.609E-1
2.001E-1
4 98
7 module 170 Genes in module 170 MSigDb: C4 - CM: Cancer Modules 9.902E-4 2.698E-2
1.609E-1
2.159E-1
4 100
8 module 79 Genes in module 79 MSigDb: C4 - CM: Cancer Modules 9.902E-4 2.698E-2
1.609E-1
2.159E-1
4 100
Show 3 more annotations

16: MicroRNA [Display Chart] 762 annotations before applied cutoff / 19844 genes in category

No results to display

17: Drug [Display Chart] 12775 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C487081 belinostat CTD 5.918E-7 7.560E-3
7.585E-2
7.560E-3 9 417
2 CID000005352 aflodac Stitch 3.676E-6 1.749E-2
1.755E-1
4.696E-2 7 271
3 CID000008181 methyl palmitate Stitch 5.808E-6 1.749E-2
1.755E-1
7.419E-2
3 15
4 4754 UP PNU-0230031 [267429-39-0]; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 7.535E-6 1.749E-2
1.755E-1
9.627E-2
6 197
5 CID000063062 E)-4-hydroxytamoxifen Stitch 7.535E-6 1.749E-2
1.755E-1
9.627E-2
6 197
6 5502 UP Isometheptene mucate; Up 200; 8.2uM; MCF7; HT HG-U133A Broad Institute CMAP 8.215E-6 1.749E-2
1.755E-1
1.049E-1
6 200
7 C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone CTD 1.089E-5 1.843E-2
1.849E-1
1.391E-1
7 320
8 C011512 alpha-naphthoflavone CTD 1.438E-5 1.843E-2
1.849E-1
1.837E-1
5 129
9 CID000105020 benzo(a)pyrene-7,8-dione Stitch 1.443E-5 1.843E-2
1.849E-1
1.843E-1
3 20
10 C076588 benzo(a)pyrene-7,8-dione CTD 1.443E-5 1.843E-2
1.849E-1
1.843E-1
3 20
11 CID000302580 NSC189675 Stitch 1.691E-5 1.963E-2
1.970E-1
2.160E-1
2 3
12 C002791 bismuth tripotassium dicitrate CTD 1.856E-5 1.976E-2
1.983E-1
2.372E-1
5 136
13 D004002 Clodronic Acid CTD 2.364E-5 2.116E-2
2.123E-1
3.020E-1
6 241
14 C032668 1-nitropyrene CTD 2.593E-5 2.116E-2
2.123E-1
3.313E-1
6 245
15 C009237 senecionine CTD 2.996E-5 2.116E-2
2.123E-1
3.827E-1
4 74
16 CID000003712 indole-3-carbinol Stitch 3.375E-5 2.116E-2
2.123E-1
4.311E-1
5 154
17 C002802 tungsten carbide CTD 3.481E-5 2.116E-2
2.123E-1
4.447E-1
5 155
18 CID000010212 imperatorin Stitch 4.555E-5 2.116E-2
2.123E-1
5.819E-1
3 29
19 CID000009128 B(e)P Stitch 4.555E-5 2.116E-2
2.123E-1
5.819E-1
3 29
20 C004742 daidzein CTD 4.829E-5 2.116E-2
2.123E-1
6.169E-1
5 166
21 D001374 Azacitidine CTD 5.071E-5 2.116E-2
2.123E-1
6.478E-1
7 407
22 C017228 benzo(a)pyrene 7,8-dihydrodiol CTD 5.584E-5 2.116E-2
2.123E-1
7.134E-1
3 31
23 C119493 glucoerucin CTD 5.618E-5 2.116E-2
2.123E-1
7.177E-1
2 5
24 C501268 naphtho(2,3-a)pyrene CTD 5.618E-5 2.116E-2
2.123E-1
7.177E-1
2 5
25 C468646 5,12-naphthacenequinone CTD 5.618E-5 2.116E-2
2.123E-1
7.177E-1
2 5
26 C098607 JP8 aviation fuel CTD 5.998E-5 2.116E-2
2.123E-1
7.663E-1
7 418
27 D014639 Vanadium CTD 6.039E-5 2.116E-2
2.123E-1
7.715E-1
5 174
28 CID006483648 panduratin A Stitch 6.755E-5 2.116E-2
2.123E-1
8.629E-1
3 33
29 C052920 trimethylarsine oxide CTD 6.755E-5 2.116E-2
2.123E-1
8.629E-1
3 33
30 7084 UP MS-275; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 7.668E-5 2.116E-2
2.123E-1
9.796E-1
5 183
31 MESH:D011471/D004958-M Prostatic Neoplasms affected by Estradiol CTD Marker 8.280E-5 2.116E-2
2.123E-1
1.000E0
5 186
32 1334 UP Myricetin [529-44-2]; Up 200; 12.6uM; HL60; HT HG-U133A Broad Institute CMAP 8.280E-5 2.116E-2
2.123E-1
1.000E0
5 186
33 CID000003136 DMNQ Stitch 8.319E-5 2.116E-2
2.123E-1
1.000E0
4 96
34 CID000344530 AC1L80RH Stitch 8.414E-5 2.116E-2
2.123E-1
1.000E0
2 6
35 MESH:D008175/D015127-M Lung Neoplasms affected by 9,10-Dimethyl-1,2-benzanthracene CTD Marker 8.414E-5 2.116E-2
2.123E-1
1.000E0
2 6
36 CID003086063 Tecoflex Stitch 8.414E-5 2.116E-2
2.123E-1
1.000E0
2 6
37 MESH:D001943/C038491-T Breast Neoplasms affected by allyl sulfide CTD Therapeutic 8.414E-5 2.116E-2
2.123E-1
1.000E0
2 6
38 CID000009149 phenalene Stitch 8.414E-5 2.116E-2
2.123E-1
1.000E0
2 6
39 CID000153937 AC1L4BE3 Stitch 8.414E-5 2.116E-2
2.123E-1
1.000E0
2 6
40 CID011073339 1,2,4-triazol-3-one Stitch 8.414E-5 2.116E-2
2.123E-1
1.000E0
2 6
41 MESH:D011471/D004054-T Prostatic Neoplasms affected by Diethylstilbestrol CTD Therapeutic 8.662E-5 2.116E-2
2.123E-1
1.000E0
4 97
42 C004656 chloroacetaldehyde CTD 8.758E-5 2.116E-2
2.123E-1
1.000E0
6 305
43 CID005326976 CK2 inhibitor 2 Stitch 8.795E-5 2.116E-2
2.123E-1
1.000E0
3 36
44 5623 UP Clioquinol [130-26-7]; Up 200; 13uM; MCF7; HT HG-U133A Broad Institute CMAP 9.154E-5 2.116E-2
2.123E-1
1.000E0
5 190
45 828 UP 5252917; Up 200; 14uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.010E-4 2.116E-2
2.123E-1
1.000E0
5 194
46 7359 UP Benzathine benzylpenicillin [5928-84-7]; Up 200; 4.2uM; MCF7; HT HG-U133A Broad Institute CMAP 1.034E-4 2.116E-2
2.123E-1
1.000E0
5 195
47 CID000010680 Flavone Stitch 1.053E-4 2.116E-2
2.123E-1
1.000E0
4 102
48 7015 UP Moxisylyte hydrochoride [964-52-3]; Up 200; 12.6uM; MCF7; HT HG-U133A Broad Institute CMAP 1.060E-4 2.116E-2
2.123E-1
1.000E0
5 196
49 3364 UP Acetaminophen [103-90-2]; Up 200; 26.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.085E-4 2.116E-2
2.123E-1
1.000E0
5 197
50 2998 DN Trichlormethiazide [133-67-5]; Down 200; 10.6uM; HL60; HT HG-U133A Broad Institute CMAP 1.085E-4 2.116E-2
2.123E-1
1.000E0
5 197
Show 45 more annotations

18: Disease [Display Chart] 1036 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0238239 Light chain disease DisGeNET BeFree 2.482E-5 2.572E-2
1.934E-1
2.572E-2 2 3
2 umls:C0339573 Glaucoma, Primary Open Angle DisGeNET Curated 1.202E-4 3.816E-2
2.870E-1
1.246E-1
5 167
3 umls:C0221259 Trichiasis DisGeNET BeFree 1.725E-4 3.816E-2
2.870E-1
1.787E-1
2 7
4 umls:C0878500 Intraepithelial Neoplasia DisGeNET BeFree 5.793E-4 3.816E-2
2.870E-1
6.001E-1
4 132
5 umls:C0042025 Urinary Stress Incontinence DisGeNET BeFree 7.377E-4 3.816E-2
2.870E-1
7.643E-1
2 14
6 umls:C1334177 Infiltrating Cervical Carcinoma DisGeNET BeFree 7.386E-4 3.816E-2
2.870E-1
7.652E-1
3 61
7 umls:C0268381 Primary amyloidosis DisGeNET BeFree 8.496E-4 3.816E-2
2.870E-1
8.802E-1
2 15
8 umls:C0020456 Hyperglycemia DisGeNET Curated 1.012E-3 3.816E-2
2.870E-1
1.000E0
6 400
9 umls:C0085078 Lysosomal Storage Diseases DisGeNET BeFree 1.296E-3 3.816E-2
2.870E-1
1.000E0
3 74
10 umls:C0037019 Shy-Drager Syndrome DisGeNET Curated 1.565E-3 3.816E-2
2.870E-1
1.000E0
3 79
11 20090422:Soranzo Height GWAS 1.680E-3 3.816E-2
2.870E-1
1.000E0
2 21
12 umls:C1568272 Tendinopathy DisGeNET BeFree 1.680E-3 3.816E-2
2.870E-1
1.000E0
2 21
13 umls:C0017601 Glaucoma DisGeNET Curated 1.795E-3 3.816E-2
2.870E-1
1.000E0
4 179
14 umls:C0741682 Premenopausal breast cancer DisGeNET BeFree 1.845E-3 3.816E-2
2.870E-1
1.000E0
2 22
15 umls:C0028840 Ocular Hypertension DisGeNET Curated 1.845E-3 3.816E-2
2.870E-1
1.000E0
2 22
16 umls:C0393571 Multiple System Atrophy DisGeNET BeFree 1.866E-3 3.816E-2
2.870E-1
1.000E0
3 84
17 umls:C0598935 Tumor Initiation DisGeNET BeFree 1.907E-3 3.816E-2
2.870E-1
1.000E0
4 182
18 umls:C0333186 Restenosis DisGeNET BeFree 1.985E-3 3.816E-2
2.870E-1
1.000E0
4 184
19 umls:C0011616 Contact Dermatitis DisGeNET Curated 1.996E-3 3.816E-2
2.870E-1
1.000E0
3 86
20 umls:C0346429 Multiple malignancy DisGeNET BeFree 2.230E-3 3.816E-2
2.870E-1
1.000E0
4 190
21 20090507:Lesch Attention deficit hyperactivity disorder GWAS 2.383E-3 3.816E-2
2.870E-1
1.000E0
2 25
22 umls:C0011633 Dermatomyositis DisGeNET Curated 2.731E-3 3.816E-2
2.870E-1
1.000E0
3 96
23 umls:C3809665 NEURODEGENERATION WITH OPTIC ATROPHY, CHILDHOOD-ONSET DisGeNET Curated 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
24 cv:C1864651 Gaucher disease, atypical, due to saposin C deficiency Clinical Variations 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
25 umls:C0409667 Juvenile Chronic Polyarthritis DisGeNET BeFree 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
26 umls:C1839264 SPASTIC PARAPLEGIA 2, X-LINKED (disorder) DisGeNET Curated 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
27 cv:C0268262 Sphingolipid activator protein 1 deficiency Clinical Variations 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
28 249900 METACHROMATIC LEUKODYSTROPHY DUE TO SAPOSIN B DEFICIENCY OMIM 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
29 cv:C0205711 Pelizaeus-Merzbacher disease Clinical Variations 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
30 611721 COMBINED SAPOSIN DEFICIENCY OMIM 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
31 cv:C2673635 Combined saposin deficiency Clinical Variations 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
32 cv:C1840547 Abacavir hypersensitivity Clinical Variations 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
33 cv:CN160494 Allopurinol response Clinical Variations 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
34 umls:C2673266 KRABBE DISEASE, ATYPICAL, DUE TO SAPOSIN A DEFICIENCY DisGeNET Curated 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
35 umls:C4015156 MICROCEPHALY 12, PRIMARY, AUTOSOMAL RECESSIVE DisGeNET Curated 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
36 umls:C1853154 Nemaline Myopathy 7 DisGeNET Curated 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
37 umls:C0268262 Metachromatic Leukodystrophy due to Saposin B Deficiency DisGeNET Curated 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
38 312080 PELIZAEUS-MERZBACHER DISEASE; PMD OMIM 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
39 610539 GAUCHER DISEASE, ATYPICAL, DUE TO SAPOSIN C DEFICIENCY OMIM 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
40 cv:CN077964 Carbamazepine response Clinical Variations 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
41 cv:C2673266 Krabbe disease atypical due to Saposin A deficiency Clinical Variations 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
42 umls:C0155118 Corneal degeneration DisGeNET BeFree 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
43 cv:CN180639 Neurodegeneration with optic atrophy, childhood-onset Clinical Variations 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
44 umls:C2752061 Cerebral Palsy, Spastic Quadriplegic, 2 DisGeNET Curated 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
45 cv:C0020302 Glaucoma, congenital Clinical Variations 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
46 cv:C1859309 Syndactyly Cenani Lenz type Clinical Variations 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
47 cv:C1859194 Griscelli syndrome type 1 Clinical Variations 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
48 umls:C3150899 PARKINSON DISEASE 5, AUTOSOMAL DOMINANT DisGeNET Curated 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
49 cv:CN220919 Microcephaly 12, primary, autosomal recessive Clinical Variations 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
50 cv:CN077825 Carbamazepine hypersensitivity Clinical Variations 2.910E-3 3.816E-2
2.870E-1
1.000E0
1 1
Show 45 more annotations