Toppgene analysis for aggregated_1964_log, IC12, positive side

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1: GO: Molecular Function [Display Chart] 634 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001730 2'-5'-oligoadenylate synthetase activity 8.117E-6 5.146E-3 3.618E-2 5.146E-3 3 4
2 GO:0004860 protein kinase inhibitor activity 1.425E-4 3.462E-2
2.434E-1
9.034E-2
 7 89
3 GO:0019210 kinase inhibitor activity 1.638E-4 3.462E-2
2.434E-1
1.039E-1
 7 91
4 GO:0003725 double-stranded RNA binding 2.285E-4 3.622E-2
2.547E-1
1.449E-1
 6 68

2: GO: Biological Process [Display Chart] 3419 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0060337 type I interferon signaling pathway 1.679E-20 3.754E-17 3.271E-16 5.742E-17 20 81
2 GO:0071357 cellular response to type I interferon 2.196E-20 3.754E-17 3.271E-16 7.508E-17 20 82
3 GO:0034340 response to type I interferon 6.183E-20 7.047E-17 6.141E-16 2.114E-16 20 86
4 GO:0048525 negative regulation of viral process 2.671E-10 1.918E-7 1.671E-6 9.132E-7 13 95
5 GO:0035455 response to interferon-alpha 2.805E-10 1.918E-7 1.671E-6 9.589E-7 8 23
6 GO:0034341 response to interferon-gamma 3.620E-10 2.063E-7 1.798E-6 1.238E-6 16 163
7 GO:1903901 negative regulation of viral life cycle 2.323E-9 1.135E-6 9.889E-6 7.943E-6 12 92
8 GO:0043901 negative regulation of multi-organism process 4.115E-9 1.596E-6 1.391E-5 1.407E-5 15 166
9 GO:0051607 defense response to virus 4.202E-9 1.596E-6 1.391E-5 1.437E-5 21 344
10 GO:0060333 interferon-gamma-mediated signaling pathway 1.192E-8 4.074E-6 3.551E-5 4.074E-5 11 85
11 GO:0045071 negative regulation of viral genome replication 1.913E-8 5.947E-6 5.183E-5 6.542E-5 9 52
12 GO:0009615 response to virus 4.335E-8 1.235E-5 1.076E-4 1.482E-4 22 430
13 GO:0035456 response to interferon-beta 8.539E-8 2.246E-5 1.957E-4 2.919E-4 7 30
14 GO:0050792 regulation of viral process 1.681E-7 4.104E-5 3.576E-4 5.746E-4 14 189
15 GO:0071346 cellular response to interferon-gamma 2.707E-7 6.171E-5 5.377E-4 9.256E-4 12 140
16 GO:1903900 regulation of viral life cycle 4.831E-7 1.032E-4 8.997E-4 1.652E-3 13 176
17 GO:0019079 viral genome replication 7.895E-7 1.588E-4 1.384E-3 2.699E-3 10 102
18 GO:0045069 regulation of viral genome replication 8.817E-7 1.675E-4 1.460E-3 3.015E-3 9 80
19 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism 1.063E-6 1.913E-4 1.667E-3 3.634E-3 14 220
20 GO:0071222 cellular response to lipopolysaccharide 1.320E-5 2.256E-3 1.966E-2 4.513E-2 11 170
21 GO:0071219 cellular response to molecule of bacterial origin 1.927E-5 3.137E-3 2.734E-2
6.588E-2
 11 177
22 GO:0071216 cellular response to biotic stimulus 5.404E-5 8.398E-3
7.319E-2
1.848E-1
 11 198
23 GO:0002683 negative regulation of immune system process 1.304E-4 1.938E-2
1.689E-1
4.457E-1
 16 424
24 GO:1901898 negative regulation of relaxation of cardiac muscle 1.653E-4 2.260E-2
1.970E-1
5.651E-1
 2 2
25 GO:0002731 negative regulation of dendritic cell cytokine production 1.653E-4 2.260E-2
1.970E-1
5.651E-1
 2 2
26 GO:0046597 negative regulation of viral entry into host cell 1.962E-4 2.580E-2
2.249E-1
6.709E-1
 4 23
27 GO:0019058 viral life cycle 2.371E-4 3.003E-2
2.617E-1
8.108E-1
 16 447
28 GO:0071375 cellular response to peptide hormone stimulus 3.200E-4 3.908E-2
3.405E-1
1.000E0
 13 325
29 GO:2001236 regulation of extrinsic apoptotic signaling pathway 4.183E-4 4.858E-2
4.234E-1
1.000E0
 9 173
30 GO:0035457 cellular response to interferon-alpha 4.263E-4 4.858E-2
4.234E-1
1.000E0
 3 12
Show 25 more annotations

3: GO: Cellular Component [Display Chart] 303 annotations before applied cutoff / 19172 genes in category

No results to display

4: Human Phenotype [Display Chart] 624 annotations before applied cutoff / 4410 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 3038 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002418 increased susceptibility to viral infection 1.091E-5 3.314E-2
2.849E-1
 3.314E-2 11 123
2 MP:0000701 abnormal lymph node size 2.403E-5 3.571E-2
3.070E-1
7.300E-2
 16 271
3 MP:0020185 altered susceptibility to viral infection 3.527E-5 3.571E-2
3.070E-1
1.071E-1
 12 165
4 MP:0001839 abnormal level of surface class I molecules 6.032E-5 4.581E-2
3.938E-1
1.832E-1
 4 13

6: Domain [Display Chart] 1443 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR006117 2-5-oligoadenylate synth CS InterPro 8.434E-6 1.521E-3 1.195E-2 1.217E-2 3 4
2 IPR018952 2-5-oligoAdlate synth 1 dom2/C InterPro 8.434E-6 1.521E-3 1.195E-2 1.217E-2 3 4
3 1.10.1410.20 - Gene3D 8.434E-6 1.521E-3 1.195E-2 1.217E-2 3 4
4 PS00832 25A SYNTH 1 PROSITE 8.434E-6 1.521E-3 1.195E-2 1.217E-2 3 4
5 PS50152 25A SYNTH 3 PROSITE 8.434E-6 1.521E-3 1.195E-2 1.217E-2 3 4
6 PF10421 OAS1 C Pfam 8.434E-6 1.521E-3 1.195E-2 1.217E-2 3 4
7 IPR026774 2-5A synthase InterPro 8.434E-6 1.521E-3 1.195E-2 1.217E-2 3 4
8 PS00833 25A SYNTH 2 PROSITE 8.434E-6 1.521E-3 1.195E-2 1.217E-2 3 4
9 IPR006116 2-5-oligoadenylate synth N InterPro 2.088E-5 3.348E-3 2.629E-2 3.013E-2 3 5
10 IPR028017 HCAR2/3 rcpt InterPro 1.662E-4 1.624E-2
1.275E-1
2.398E-1
 2 2
11 PS00034 PAIRED 1 PROSITE 1.688E-4 1.624E-2
1.275E-1
2.436E-1
 3 9
12 SM00351 PAX SMART 1.688E-4 1.624E-2
1.275E-1
2.436E-1
 3 9
13 PF00292 PAX Pfam 1.688E-4 1.624E-2
1.275E-1
2.436E-1
 3 9
14 PS51057 PAIRED 2 PROSITE 1.688E-4 1.624E-2
1.275E-1
2.436E-1
 3 9
15 IPR001523 Paired dom InterPro 1.688E-4 1.624E-2
1.275E-1
2.436E-1
 3 9
16 PF01909 NTP transf 2 Pfam 3.253E-4 2.761E-2
2.168E-1
4.694E-1
 3 11
17 IPR002934 Polymerase NTP transf dom InterPro 3.253E-4 2.761E-2
2.168E-1
4.694E-1
 3 11
18 IPR003070 Nuc orph rcpt InterPro 4.942E-4 3.962E-2
3.111E-1
7.132E-1
 2 3
Show 13 more annotations

7: Pathway [Display Chart] 1063 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 187104 Interferon alpha/beta signaling BioSystems: REACTOME 2.172E-18 2.308E-15 1.742E-14 2.308E-15 18 66
2 187103 Interferon Signaling BioSystems: REACTOME 8.994E-16 4.780E-13 3.607E-12 9.560E-13 23 173
3 366171 Cytokine Signaling in Immune system BioSystems: REACTOME 1.697E-13 6.012E-11 4.537E-10 1.803E-10 26 291
4 198918 Type II interferon signaling (IFNG) BioSystems: WikiPathways 6.870E-7 1.826E-4 1.378E-3 7.303E-4 8 50
5 187106 Interferon gamma signaling BioSystems: REACTOME 1.051E-6 2.233E-4 1.685E-3 1.117E-3 9 71
6 530761 ISG15 antiviral mechanism BioSystems: REACTOME 1.157E-5 1.758E-3 1.326E-2 1.230E-2 8 72
7 530760 Antiviral mechanism by IFN-stimulated genes BioSystems: REACTOME 1.157E-5 1.758E-3 1.326E-2 1.230E-2 8 72
8 198885 IL-2 Signaling pathway BioSystems: WikiPathways 3.518E-5 4.674E-3 3.528E-2 3.739E-2 6 42
9 217173 Influenza A BioSystems: KEGG 7.925E-5 9.360E-3
7.063E-2
8.424E-2
 11 179
10 377873 Herpes simplex infection BioSystems: KEGG 1.229E-4 1.307E-2
9.860E-2
1.307E-1
 11 188
11 173973 Hepatitis C BioSystems: KEGG 1.736E-4 1.628E-2
1.228E-1
1.846E-1
 9 133
12 213306 Measles BioSystems: KEGG 1.838E-4 1.628E-2
1.228E-1
1.953E-1
 9 134
13 833831 Hydroxycarboxylic acid-binding receptors BioSystems: REACTOME 6.664E-4 4.352E-2
3.284E-1
7.084E-1
 2 3
14 198832 Adipogenesis BioSystems: WikiPathways 8.745E-4 4.352E-2
3.284E-1
9.296E-1
 8 133
15 137976 IL2-mediated signaling events BioSystems: Pathway Interaction Database 1.058E-3 4.352E-2
3.284E-1
1.000E0
 5 52
16 906011 Defective MUT causes methylmalonic aciduria mut type BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
17 906009 Defective MMAB causes methylmalonic aciduria type cblB BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
18 906015 Defective BTD causes biotidinase deficiency BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
19 905998 Defects in vitamin and cofactor metabolism BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
20 906001 Defective CUBN causes hereditary megaloblastic anemia 1 BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
21 905999 Defects in cobalamin (B12) metabolism BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
22 906004 Defective GIF causes intrinsic factor deficiency BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
23 906002 Defective TCN2 causes hereditary megaloblastic anemia BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
24 906008 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
25 906005 Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
26 906000 Defective AMN causes hereditary megaloblastic anemia 1 BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
27 906012 Defective CD320 causes methylmalonic aciduria BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
28 106249 Metabolism of vitamins and cofactors BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
29 906007 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
30 906014 Defective HLCS causes multiple carboxylase deficiency BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
31 906003 Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
32 906006 Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
33 106250 Metabolism of water-soluble vitamins and cofactors BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
34 906013 Defects in biotin (Btn) metabolism BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
35 906010 Defective MMAA causes methylmalonic aciduria type cblA BioSystems: REACTOME 1.433E-3 4.352E-2
3.284E-1
1.000E0
 6 82
Show 30 more annotations

8: Pubmed [Display Chart] 33250 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 26116899 Genome-wide transcriptional profiling reveals that HIV-1 Vpr differentially regulates interferon-stimulated genes in human monocyte-derived dendritic cells. Pubmed 6.522E-23 2.169E-18 2.383E-17 2.169E-18 15 53
2 24742347 HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells. Pubmed 2.098E-17 3.488E-13 3.833E-12 6.976E-13 11 37
3 25170834 HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages. Pubmed 1.684E-15 1.866E-11 2.051E-10 5.599E-11 8 15
4 20628624:gr Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". GeneRIF 8.729E-15 5.805E-11 6.379E-10 2.902E-10 15 172
5 20628624 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". Pubmed 8.729E-15 5.805E-11 6.379E-10 2.902E-10 15 172
6 22647704 Vpu-deficient HIV strains stimulate innate immune signaling responses in target cells. Pubmed 1.909E-13 1.058E-9 1.163E-8 6.348E-9 7 14
7 25905045 Comparative proteomic analyses demonstrate enhanced interferon and STAT-1 activation in reovirus T3D-infected HeLa cells. Pubmed 2.554E-12 1.213E-8 1.333E-7 8.491E-8 5 5
8 24162774 The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-Ã?1 production and FcRL4 expression. Pubmed 3.955E-10 1.644E-6 1.806E-5 1.315E-5 10 119
9 19453261:gr High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. GeneRIF 8.248E-10 2.743E-6 3.014E-5 2.743E-5 15 383
10 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 8.248E-10 2.743E-6 3.014E-5 2.743E-5 15 383
11 12447867:gr Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study. GeneRIF 1.152E-9 3.192E-6 3.508E-5 3.831E-5 5 11
12 12447867 Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study. Pubmed 1.152E-9 3.192E-6 3.508E-5 3.831E-5 5 11
13 12539042 HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. Pubmed 1.884E-9 4.818E-6 5.294E-5 6.263E-5 7 44
14 23333304 CBFÃ? stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Pubmed 8.498E-9 2.018E-5 2.218E-4 2.826E-4 10 163
15 19694548 Human immunodeficiency virus, restriction factors, and interferon. Pubmed 1.855E-8 4.112E-5 4.518E-4 6.167E-4 4 7
16 23898208 Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. Pubmed 2.914E-8 6.056E-5 6.655E-4 9.689E-4 8 98
17 16009940 Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. Pubmed 6.493E-8 1.224E-4 1.345E-3 2.159E-3 9 152
18 24886089 DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. Pubmed 6.627E-8 1.224E-4 1.345E-3 2.203E-3 4 9
19 24066097 Restriction genes for retroviruses influence the risk of multiple sclerosis. Pubmed 1.121E-7 1.380E-4 1.517E-3 3.727E-3 3 3
20 20001730:gr Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination. GeneRIF 1.121E-7 1.380E-4 1.517E-3 3.727E-3 3 3
21 9790745 The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms. Pubmed 1.121E-7 1.380E-4 1.517E-3 3.727E-3 3 3
22 16014697 Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? Pubmed 1.121E-7 1.380E-4 1.517E-3 3.727E-3 3 3
23 2440675 Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies. Pubmed 1.121E-7 1.380E-4 1.517E-3 3.727E-3 3 3
24 23337612 Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection. Pubmed 1.121E-7 1.380E-4 1.517E-3 3.727E-3 3 3
25 20001730 Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination. Pubmed 1.121E-7 1.380E-4 1.517E-3 3.727E-3 3 3
26 23337612:gr Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection. GeneRIF 1.121E-7 1.380E-4 1.517E-3 3.727E-3 3 3
27 16014697:gr Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? GeneRIF 1.121E-7 1.380E-4 1.517E-3 3.727E-3 3 3
28 24992036 G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA. Pubmed 1.722E-7 2.045E-4 2.248E-3 5.727E-3 4 11
29 19142206:gr Maternal transmission effects of the PAX genes among cleft case-parent trios from four populations. GeneRIF 4.467E-7 4.014E-4 4.411E-3 1.485E-2 3 4
30 6548414 Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells. Pubmed 4.467E-7 4.014E-4 4.411E-3 1.485E-2 3 4
31 23529855 Hepatitis C virus impairs TLR3 signaling and inhibits IFN-¿ 1 expression in human hepatoma cell line. Pubmed 4.467E-7 4.014E-4 4.411E-3 1.485E-2 3 4
32 21050126 Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease. Pubmed 4.467E-7 4.014E-4 4.411E-3 1.485E-2 3 4
33 19923450 Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection. Pubmed 4.467E-7 4.014E-4 4.411E-3 1.485E-2 3 4
34 14525795 Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1. Pubmed 4.467E-7 4.014E-4 4.411E-3 1.485E-2 3 4
35 21050126:gr Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease. GeneRIF 4.467E-7 4.014E-4 4.411E-3 1.485E-2 3 4
36 19142206 Maternal transmission effects of the PAX genes among cleft case-parent trios from four populations. Pubmed 4.467E-7 4.014E-4 4.411E-3 1.485E-2 3 4
37 14525795:gr Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1. GeneRIF 4.467E-7 4.014E-4 4.411E-3 1.485E-2 3 4
38 24667918 Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02 AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. Pubmed 8.706E-7 7.618E-4 8.371E-3 2.895E-2 7 105
39 16997058 Hemodialysis modulates gene expression profile in skeletal muscle. Pubmed 1.113E-6 9.250E-4 1.016E-2 3.700E-2 3 5
40 16997058:gr Hemodialysis modulates gene expression profile in skeletal muscle. GeneRIF 1.113E-6 9.250E-4 1.016E-2 3.700E-2 3 5
41 20467438 The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. Pubmed 1.187E-6 9.625E-4 1.058E-2 3.946E-2 10 277
42 20331378 Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. Pubmed 1.346E-6 1.041E-3 1.144E-2 4.477E-2 7 112
43 20331378:gr Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. GeneRIF 1.346E-6 1.041E-3 1.144E-2 4.477E-2 7 112
44 23149075 Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network. Pubmed 1.962E-6 1.483E-3 1.629E-2
6.524E-2
 4 19
45 11737038 Distribution of HLA-A, B alleles and polymorphisms of TAP and LMP genes in Korean patients with atopic dermatitis. Pubmed 2.218E-6 1.603E-3 1.761E-2
7.373E-2
 3 6
46 11737038:gr Distribution of HLA-A, B alleles and polymorphisms of TAP and LMP genes in Korean patients with atopic dermatitis. GeneRIF 2.218E-6 1.603E-3 1.761E-2
7.373E-2
 3 6
47 14499622 Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. Pubmed 6.062E-6 3.939E-3 4.329E-2
2.016E-1
 5 53
48 19559055:gr A pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients. GeneRIF 6.165E-6 3.939E-3 4.329E-2
2.050E-1
 3 8
49 19559055 A pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients. Pubmed 6.165E-6 3.939E-3 4.329E-2
2.050E-1
 3 8
50 24554542 Identification of genetic risk factors for maxillary lateral incisor agenesis. Pubmed 6.165E-6 3.939E-3 4.329E-2
2.050E-1
 3 8
Show 45 more annotations

9: Interaction [Display Chart] 3947 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PARP9 PARP9 interactions 1.194E-5 4.711E-2
4.173E-1
 4.711E-2 4 11

10: Cytoband [Display Chart] 202 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9p22.3 9p22.3 1.491E-4 1.843E-2
1.085E-1
 3.011E-2 3 15
2 12q24.2 12q24.2 1.825E-4 1.843E-2
1.085E-1
 3.687E-2 3 16
3 21q22.3 21q22.3 4.458E-4 3.002E-2
1.767E-1
9.005E-2
 6 137
4 13q12 13q12 6.326E-4 3.195E-2
1.881E-1
1.278E-1
 3 24
5 8p21.2 8p21.2 9.001E-4 3.636E-2
2.141E-1
1.818E-1
 3 27

11: Transcription Factor Binding Site [Display Chart] 531 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$OCT Q6 V$OCT Q6 6.309E-6 3.350E-3 2.296E-2 3.350E-3 14 220
2 V$IRF7 01 V$IRF7 01 2.143E-5 5.689E-3 3.898E-2 1.138E-2 13 213
3 V$CREBP1 Q2 V$CREBP1 Q2 4.359E-5 7.716E-3
5.288E-2
 2.315E-2 12 196
4 V$STAT5A 01 V$STAT5A 01 6.136E-5 8.146E-3
5.582E-2
 3.258E-2 12 203
5 V$TCF11 01 V$TCF11 01 1.372E-4 1.332E-2
9.126E-2
7.287E-2
 11 188
6 V$OCT1 Q5 01 V$OCT1 Q5 01 1.505E-4 1.332E-2
9.126E-2
7.990E-2
 12 223
7 TTCYNRGAA V$STAT5B 01 TTCYNRGAA V$STAT5B 01 2.078E-4 1.347E-2
9.229E-2
1.103E-1
 13 266
8 YATGNWAAT V$OCT C YATGNWAAT V$OCT C 2.192E-4 1.347E-2
9.229E-2
1.164E-1
 14 304
9 V$STAT5B 01 V$STAT5B 01 2.574E-4 1.347E-2
9.229E-2
1.367E-1
 11 202
10 V$CREB Q4 V$CREB Q4 2.687E-4 1.347E-2
9.229E-2
1.427E-1
 11 203
11 V$CREB Q4 01 V$CREB Q4 01 2.790E-4 1.347E-2
9.229E-2
1.481E-1
 10 171
12 V$OCT1 Q6 V$OCT1 Q6 3.898E-4 1.657E-2
1.136E-1
2.070E-1
 11 212
13 V$STAT 01 V$STAT 01 4.057E-4 1.657E-2
1.136E-1
2.154E-1
 11 213
14 V$CREB Q2 01 V$CREB Q2 01 4.588E-4 1.703E-2
1.167E-1
2.436E-1
 10 182
15 V$OCT C V$OCT C 4.937E-4 1.703E-2
1.167E-1
2.622E-1
 11 218
16 V$OCT1 01 V$OCT1 01 5.131E-4 1.703E-2
1.167E-1
2.725E-1
 11 219
17 TGACGTCA V$ATF3 Q6 TGACGTCA V$ATF3 Q6 5.920E-4 1.849E-2
1.267E-1
3.144E-1
 10 188
18 V$OCT1 B V$OCT1 B 6.676E-4 1.969E-2
1.350E-1
3.545E-1
 11 226
19 V$CEBPA 01 V$CEBPA 01 9.193E-4 2.569E-2
1.761E-1
4.881E-1
 10 199
20 V$ATF4 Q2 V$ATF4 Q2 1.111E-3 2.779E-2
1.904E-1
5.898E-1
 10 204
21 V$IRF2 01 V$IRF2 01 1.152E-3 2.779E-2
1.904E-1
6.119E-1
 7 106
22 V$CREB Q2 V$CREB Q2 1.241E-3 2.779E-2
1.904E-1
6.588E-1
 10 207
23 V$RSRFC4 01 V$RSRFC4 01 1.287E-3 2.779E-2
1.904E-1
6.832E-1
 10 208
24 V$HNF3ALPHA Q6 V$HNF3ALPHA Q6 1.300E-3 2.779E-2
1.904E-1
6.904E-1
 9 173
25 V$HFH8 01 V$HFH8 01 1.354E-3 2.779E-2
1.904E-1
7.187E-1
 9 174
26 WGTTNNNNNAAA UNKNOWN WGTTNNNNNAAA UNKNOWN 1.361E-3 2.779E-2
1.904E-1
7.225E-1
 16 450
27 V$CREB 01 V$CREB 01 1.484E-3 2.806E-2
1.923E-1
7.882E-1
 10 212
28 V$OCT1 05 V$OCT1 05 1.538E-3 2.806E-2
1.923E-1
8.164E-1
 10 213
29 V$CREBP1CJUN 01 V$CREBP1CJUN 01 1.538E-3 2.806E-2
1.923E-1
8.164E-1
 10 213
30 V$FOX Q2 V$FOX Q2 1.585E-3 2.806E-2
1.923E-1
8.418E-1
 9 178
31 V$E4F1 Q6 V$E4F1 Q6 2.021E-3 3.461E-2
2.372E-1
1.000E0
 10 221
32 V$FREAC4 01 V$FREAC4 01 2.248E-3 3.727E-2
2.554E-1
1.000E0
 7 119
33 TGAYRTCA V$ATF3 Q6 TGAYRTCA V$ATF3 Q6 2.316E-3 3.727E-2
2.554E-1
1.000E0
 15 430
34 V$ATF1 Q6 V$ATF1 Q6 2.566E-3 4.008E-2
2.747E-1
1.000E0
 9 191
35 STTTCRNTTT V$IRF Q6 STTTCRNTTT V$IRF Q6 2.845E-3 4.317E-2
2.958E-1
1.000E0
 8 158
36 V$FREAC7 01 V$FREAC7 01 2.958E-3 4.363E-2
2.990E-1
1.000E0
 8 159
Show 31 more annotations

12: Gene Family [Display Chart] 135 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 675 Paired boxes genenames.org 6.236E-5 8.419E-3 4.619E-2 8.419E-3 3 9
2 200 Hydroxy-carboxylic acid receptors genenames.org 2.527E-4 1.706E-2
9.359E-2
 3.412E-2 2 3
3 684 Zinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases genenames.org 4.781E-4 2.152E-2
1.180E-1
6.455E-2
 3 17
4 954 Phospholipid scramblases genenames.org 8.322E-4 2.809E-2
1.541E-1
1.124E-1
 2 5
5 471 CD molecules|V-set domain containing|Immunoglobulin like domain containing|Carcinoembryonic antigen related cell adhesion molecule family genenames.org 1.110E-3 2.998E-2
1.645E-1
1.499E-1
 11 394

13: Coexpression [Display Chart] 6899 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSE42021 TREG VS TCONV PLN UP Genes up-regulated in cells from peripheral lymph nodes: T reg versus T conv. MSigDB C7: Immunologic Signatures (v5.1) 8.946E-33 6.172E-29 5.812E-28 6.172E-29 36 200
2 GSE21546 WT VS SAP1A KO DP THYMOCYTES UP Genes up-regulated in untreated double positive thymocytes: wildtype versus ELK4 [GeneID=2005] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.641E-31 5.659E-28 5.329E-27 1.132E-27 35 199
3 M6670 Genes up-regulated in CD34+ [GeneID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID=4928;3205] off a retroviral vector at 3 days after transduction. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.347E-30 7.194E-27 6.774E-26 2.309E-26 33 182
4 GSE42021 TREG PLN VS TREG PRECURSORS THYMUS DN Genes down-regulated in T reg from: peripheral lymph nodes versus thymic precursors. MSigDB C7: Immunologic Signatures (v5.1) 4.171E-30 7.194E-27 6.774E-26 2.878E-26 34 200
5 M5913 Genes up-regulated in response to IFNG [GeneID=3458]. MSigDB H: Hallmark Gene Sets (v5.1) 8.490E-29 9.763E-26 9.193E-25 5.858E-25 33 200
6 M3288 Genes down-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) versus PBMC 7 days after stimulation with YF17D vaccine. MSigDB C7: Immunologic Signatures (v5.1) 8.490E-29 9.763E-26 9.193E-25 5.858E-25 33 200
7 GSE42724 NAIVE BCELL VS PLASMABLAST UP Genes up-regulated in B lymphocytes: naïve versus plasmablasts. MSigDB C7: Immunologic Signatures (v5.1) 1.408E-27 1.214E-24 1.143E-23 9.713E-24 32 199
8 M3302 Genes down-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) 3 days after stimulation with YF17D vaccine versus PBMC 7 days after the stimulation. MSigDB C7: Immunologic Signatures (v5.1) 1.408E-27 1.214E-24 1.143E-23 9.713E-24 32 199
9 M3279 Genes down-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) versus PBMC stimulated with YF17D vaccine. MSigDB C7: Immunologic Signatures (v5.1) 3.114E-26 2.387E-23 2.248E-22 2.148E-22 31 200
10 GSE42021 CD24HI VS CD24INT TREG THYMUS DN Genes down-regulated in thymic T reg: CD24 high [GeneID=100133941] versus CD24 int [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v5.1) 5.601E-25 3.220E-22 3.032E-21 3.864E-21 30 200
11 GSE37533 PPARG1 FOXP3 VS FOXP3 TRANSDUCED CD4 TCELL DN Genes down-regulated in CD4 [GeneID=920] over-expressing: FOXP3 [GeneID=50943] and PPARg1 form of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v5.1) 5.601E-25 3.220E-22 3.032E-21 3.864E-21 30 200
12 M4520 Genes down-regulated in comparison of unstimulated dendritic cells (DC) versus 1 day DC stimulated with LPS (TLR4 agonist). MSigDB C7: Immunologic Signatures (v5.1) 5.601E-25 3.220E-22 3.032E-21 3.864E-21 30 200
13 M3010 Genes transcriptionally modulated in the blood of multiple sclerosis patients in response to subcutaneous treatment with recombinant IFNB1 [GeneID = 3456]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.038E-24 1.082E-21 1.019E-20 1.406E-20 23 95
14 GSE42021 TREG PLN VS CD24LO TREG THYMUS DN Genes down-regulated in T reg: peripheral lymph nodes versus thymic CD24 low [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v5.1) 9.649E-24 3.916E-21 3.687E-20 6.657E-20 29 200
15 GSE37534 UNTREATED VS PIOGLITAZONE TREATED CD4 TCELL PPARG1 AND FOXP3 TRASDUCED DN Genes down-regulated in CD4 [GeneID=920] T cells over-expressing FOXP3 [GeneID=50943] and PPARg1 form of PPARG [GeneID=5468]: untreated versus pioglitazone [PubChem=4829]. MSigDB C7: Immunologic Signatures (v5.1) 9.649E-24 3.916E-21 3.687E-20 6.657E-20 29 200
16 GSE19888 ADENOSINE A3R INH PRETREAT AND ACT BY A3R VS TCELL MEMBRANES ACT MAST CELL UP Genes up-regulated in HMC-1 (mast leukemia) cells: incubated with the peptide ALL1 and then treated with Cl-IB-MECA [PubChem=3035850] versus stimulation by T cell membranes. MSigDB C7: Immunologic Signatures (v5.1) 9.649E-24 3.916E-21 3.687E-20 6.657E-20 29 200
17 GSE37533 PPARG1 FOXP3 VS FOXP3 TRANSDUCED CD4 TCELL PIOGLITAZONE TREATED UP Genes up-regulated in CD4 [GeneID=920] T cells treated with pioglitazone [PubChem=4829] and over-expressing: FOXP3 [GeneID=50943] and PPARg1 isoform of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v5.1) 9.649E-24 3.916E-21 3.687E-20 6.657E-20 29 200
18 M8323 Up-regulated in GHOST(3)CXCR4 cells (osteosarcoma) upon ectopic expression of ILF3 [GeneID=3609]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.137E-23 4.359E-21 4.105E-20 7.847E-20 17 38
19 M17275 Genes up-regulated in CD34+ [GeneID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID=4928;3205] off a retroviral vector at 8 days after transduction. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.501E-23 2.360E-20 2.223E-19 4.485E-19 26 157
20 GSE41978 ID2 KO VS BIM KO KLRG1 LOW EFFECTOR CD8 TCELL UP Genes up-regulated in KLRG1 low [GeneID=10219] CD8 T effector cells during infection: ID2 [GeneID=10219] knockout versus BCL2L11 [GeneID=10018] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.381E-22 4.220E-20 3.974E-19 9.529E-19 28 199
21 M3311 Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) before vs after YF17D vaccination. MSigDB C7: Immunologic Signatures (v5.1) 1.381E-22 4.220E-20 3.974E-19 9.529E-19 28 199
22 M3296 Genes down-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) 1 day after stimulation with YF17D vaccine versus PBMC 7 days after the stimulation. MSigDB C7: Immunologic Signatures (v5.1) 1.381E-22 4.220E-20 3.974E-19 9.529E-19 28 199
23 GSE21360 NAIVE VS QUATERNARY MEMORY CD8 TCELL UP Genes up-regulated inCD8 T cells: naïve versus 4' memory. MSigDB C7: Immunologic Signatures (v5.1) 1.590E-22 4.220E-20 3.974E-19 1.097E-18 28 200
24 GSE19888 ADENOSINE A3R INH VS ACT WITH INHIBITOR PRETREATMENT IN MAST CELL UP Genes up-regulated in HMC-1 (mast leukemia) cells incubated the peptide ALL1 versus those followed by treatment with Cl-IB-MECA [PubChem=3035850]. MSigDB C7: Immunologic Signatures (v5.1) 1.590E-22 4.220E-20 3.974E-19 1.097E-18 28 200
25 GSE21927 SPLEEN C57BL6 VS 4T1 TUMOR BALBC MONOCYTES DN Genes down-regulated in CD11b+ cells from spleen of healthy C57BL6 mice versus CD11b+ cells from tumor infiltrating monocytes of BALB/c mice bearing 4T1 mammary carcinoma. MSigDB C7: Immunologic Signatures (v5.1) 1.590E-22 4.220E-20 3.974E-19 1.097E-18 28 200
26 GSE42021 TREG PLN VS CD24INT TREG THYMUS DN Genes down-regulated in T reg: peripheral lymph nodes versus thymic CD24 int [GeneID=100133941]. MSigDB C7: Immunologic Signatures (v5.1) 1.590E-22 4.220E-20 3.974E-19 1.097E-18 28 200
27 M3652 Genes up-regulated in HT1080 cells (fibrosarcoma) by treatment with interferon alpha for 6 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.954E-22 4.993E-20 4.702E-19 1.348E-18 20 74
28 M13453 Genes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon beta for 6 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.326E-22 8.196E-20 7.718E-19 2.295E-18 22 102
29 M9221 Genes up-regulated in primary fibroblast culture after treatment with interferon alpha for 6 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.114E-21 2.651E-19 2.496E-18 7.688E-18 19 68
30 M4292 Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 6 h versus cDCs infected with Newcastle disease virus (NDV) at 6 h. MSigDB C7: Immunologic Signatures (v5.1) 1.911E-21 4.394E-19 4.137E-18 1.318E-17 27 198
31 M4264 Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 6 h. MSigDB C7: Immunologic Signatures (v5.1) 2.189E-21 4.719E-19 4.443E-18 1.510E-17 27 199
32 M3347 Genes down-regulated in comparison of dendritic cells (DC) before and 4 h after LPS (TLR4 agonist) stimulation. MSigDB C7: Immunologic Signatures (v5.1) 2.189E-21 4.719E-19 4.443E-18 1.510E-17 27 199
33 M3093 Genes down-regulated in comparison of healthy CD4 [GeneID=920] T cells versus systemic lupus erythematosus CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v5.1) 2.506E-21 5.238E-19 4.932E-18 1.729E-17 27 200
34 M5911 Genes up-regulated in response to alpha interferon proteins. MSigDB H: Hallmark Gene Sets (v5.1) 2.779E-21 5.638E-19 5.309E-18 1.917E-17 21 97
35 M10319 Genes up-regulated in prostate cancer samples from African-American patients compared to those from the European-American patients. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.465E-21 1.274E-18 1.200E-17 4.460E-17 31 298
36 M4261 Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 4 h. MSigDB C7: Immunologic Signatures (v5.1) 2.236E-20 4.284E-18 4.034E-17 1.542E-16 26 196
37 GSE21546 ELK1 KO VS SAP1A KO AND ELK1 KO DP THYMOCYTES UP Genes up-regulated in untreated double positive thymocytes: ELK1 [GeneID=2002] knockout versus ELK1 and ELK4 [GeneID=2002;2005] knockout. MSigDB C7: Immunologic Signatures (v5.1) 2.907E-20 5.420E-18 5.104E-17 2.005E-16 26 198
38 M3286 Genes down-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) versus PBMC 3 days after stimulation with YF17D vaccine. MSigDB C7: Immunologic Signatures (v5.1) 3.768E-20 6.340E-18 5.970E-17 2.600E-16 26 200
39 GSE21360 NAIVE VS QUATERNARY MEMORY CD8 TCELL DN Genes down-regulated inCD8 T cells: naïve versus 4' memory. MSigDB C7: Immunologic Signatures (v5.1) 3.768E-20 6.340E-18 5.970E-17 2.600E-16 26 200
40 GSE33424 CD161 INT VS NEG CD8 TCELL UP Genes up-regulated in CD8 T cells: KLRB1 int [GeneID=3820] versus KLRB1- [GeneID=3820]. MSigDB C7: Immunologic Signatures (v5.1) 3.768E-20 6.340E-18 5.970E-17 2.600E-16 26 200
41 GSE37533 PPARG1 FOXP3 VS PPARG2 FOXP3 TRANSDUCED CD4 TCELL PIOGLITAZONE TREATED DN Genes down-regulated in CD4 [GeneID=920] T cells treated with pioglitazone [PubChem=4829] and over-expressing: FOXP3 [GeneID=50943] and PPARg1 isoform of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943] and PPARg2 form of PPARG [GeneID=5468]. MSigDB C7: Immunologic Signatures (v5.1) 3.768E-20 6.340E-18 5.970E-17 2.600E-16 26 200
42 M4710 Up-regulated at 8 h following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v5.1) 5.060E-20 8.311E-18 7.826E-17 3.491E-16 16 47
43 M15981 Genes up-regulated in mesenchymal stem cells (MSC) engineered to express EWS-FLI1 [GeneID=2130;2321] fusion protein. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.293E-20 8.491E-18 7.996E-17 3.651E-16 35 430
44 M5657 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with acute influenza infection versus PBMC from patients with acute S. pneumoniae infection. MSigDB C7: Immunologic Signatures (v5.1) 1.336E-19 2.094E-17 1.972E-16 9.215E-16 24 169
45 M2102 Genes repressed in SKBR3 cells (breast cancer) by mutated TP53 [GeneID=7157]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.608E-19 2.465E-17 2.321E-16 1.109E-15 16 50
46 M4267 Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 8 h. MSigDB C7: Immunologic Signatures (v5.1) 4.216E-19 6.323E-17 5.954E-16 2.909E-15 25 198
47 GSE26030 TH1 VS TH17 DAY5 POST POLARIZATION UP Genes up-regulated in T helper cells 5 days post polarization: Th1 versus Th17. MSigDB C7: Immunologic Signatures (v5.1) 5.402E-19 7.606E-17 7.162E-16 3.727E-15 25 200
48 GSE37533 PPARG2 FOXP3 VS FOXP3 TRANSDUCED CD4 TCELL DN Genes down-regulated in CD4 [GeneID=920] over-expressing: FOXP3 [GeneID=50943] and PPARg2 form of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v5.1) 5.402E-19 7.606E-17 7.162E-16 3.727E-15 25 200
49 GSE37534 UNTREATED VS ROSIGLITAZONE TREATED CD4 TCELL PPARG1 AND FOXP3 TRASDUCED DN Genes down-regulated in CD4 [GeneID=920] T ceels over-expressing FOXP3 [GeneID=920] and PPARg1 isoform of PPARG [GeneID=5468]: untreated versus rosiglitazone [PubChem=77999]. MSigDB C7: Immunologic Signatures (v5.1) 5.402E-19 7.606E-17 7.162E-16 3.727E-15 25 200
50 GSE21546 UNSTIM VS ANTI CD3 STIM ELK1 KO DP THYMOCYTES UP Genes up-regulated in double positive thymocytes with ELK1 [GeneID=2002] knockout: untreated versus stimulated by anti-CD3. MSigDB C7: Immunologic Signatures (v5.1) 3.184E-18 4.393E-16 4.137E-15 2.196E-14 24 193
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 3596 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap kidney adult RenMedVasc Tie2 500 kidney adult RenMedVasc Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.874E-26 1.753E-22 1.536E-21 1.753E-22 41 417
2 gudmap kidney adult CortVasc Tie2 k4 1000 kidney adult CortVasc Tie2 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 8.805E-23 1.583E-19 1.388E-18 3.166E-19 25 138
3 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 2.505E-20 2.818E-17 2.470E-16 9.008E-17 38 496
4 gudmap kidney adult Mesangium Meis k4 1000 kidney adult Mesangium Meis k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.134E-20 2.818E-17 2.470E-16 1.127E-16 29 258
5 gudmap kidney adult Mesangium Meis 500 kidney adult Mesangium Meis top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.201E-19 8.636E-17 7.569E-16 4.318E-16 35 429
6 gudmap kidney adult GlomCapSys Tie2 500 kidney adult GlomCapSys Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.409E-18 4.440E-15 3.892E-14 2.664E-14 33 427
7 gudmap kidney adult CortVasc Tie2 k2 500 kidney adult CortVasc Tie2 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.663E-17 8.545E-15 7.489E-14 5.981E-14 17 76
8 gudmap kidney adult RenCorpuscGlomer 500 kidney adult RenCorpuscGlomer top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.237E-16 5.562E-14 4.875E-13 4.450E-13 32 438
9 gudmap kidney adult GlomCapSys Tie2 k3 500 kidney adult GlomCapSys Tie2 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.921E-16 7.622E-14 6.681E-13 6.909E-13 17 87
10 gudmap kidney adult Mesangium Meis k3 500 kidney adult Mesangium Meis k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.120E-16 7.622E-14 6.681E-13 7.622E-13 20 139
11 gudmap kidney adult CortVasc Tie2 500 kidney adult CortVasc Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.531E-16 8.275E-14 7.253E-13 9.102E-13 31 418
12 gudmap RNAseq p2 Glomerlular Endothelial 2500 K4 gudmap RNAseq p2 Glomerlular Endothelial 2500 K4 Gudmap RNAseq 3.391E-16 1.016E-13 8.906E-13 1.219E-12 30 392
13 gudmap kidney adult GlomCapSys Tie2 200 kidney adult GlomCapSys Tie2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.593E-14 4.407E-12 3.862E-11 5.729E-11 20 173
14 gudmap kidney adult RenalCapsule k4 500 kidney adult RenalCapsule k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.729E-14 4.441E-12 3.892E-11 6.217E-11 14 64
15 endothelial SubClass DCN-hi Top 500 All endothelial SubClass DCN-hi Top 500 All Brain Map - Barres 2.634E-14 6.315E-12 5.535E-11 9.472E-11 31 495
16 gudmap kidney adult Mesangium Meis k1 200 kidney adult Mesangium Meis k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.008E-13 2.265E-11 1.985E-10 3.624E-10 12 45
17 endothelial Top 500 Cluster 0 endothelial Top 500 Cluster 0 Brain Map - Barres 1.563E-13 3.307E-11 2.898E-10 5.621E-10 17 128
18 endothelial SubClass MFSD2-hi Top 500 All endothelial SubClass MFSD2-hi Top 500 All Brain Map - Barres 1.949E-13 3.893E-11 3.413E-10 7.008E-10 30 498
19 gudmap kidney adult Mesangium Meis 200 kidney adult Mesangium Meis top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.153E-12 2.182E-10 1.912E-9 4.145E-9 18 167
20 gudmap kidney adult RenMedVasc Tie2 200 kidney adult RenMedVasc Tie2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.916E-12 3.445E-10 3.019E-9 6.889E-9 18 172
21 gudmap kidney adult GlomCapSys Tie2 k4 200 kidney adult GlomCapSys Tie2 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.878E-12 4.929E-10 4.320E-9 1.035E-8 10 33
22 GSM605823 500 Myeloid Cells, DC.103-11b+.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3 Immgen.org, GSE15907 1.652E-11 2.701E-9 2.367E-8 5.942E-8 25 409
23 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 2.575E-11 4.026E-9 3.529E-8 9.261E-8 26 453
24 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 7.154E-11 1.072E-8 9.395E-8 2.573E-7 25 438
25 gudmap kidney adult RenMedVasc Tie2 k4 200 kidney adult RenMedVasc Tie2 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.056E-10 1.519E-8 1.331E-7 3.798E-7 9 33
26 gudmap kidney adult GlomCapSys Tie2 100 kidney adult GlomCapSys Tie2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.983E-10 2.742E-8 2.404E-7 7.130E-7 12 82
27 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 500 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.078E-10 2.768E-8 2.426E-7 7.473E-7 24 424
28 JC hmvEC 1000 K3 JC hmvEC top-relative-expression-ranked 1000 k-means-cluster#3 PCBC 2.324E-10 2.984E-8 2.616E-7 8.356E-7 18 229
29 JC fibro 1000 K1 JC fibro top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 2.410E-10 2.988E-8 2.619E-7 8.665E-7 25 464
30 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 5.515E-10 6.611E-8 5.794E-7 1.983E-6 24 445
31 endothelial SubClass DCN-hi Top 500 Cluster 2 endothelial SubClass DCN-hi Top 500 Cluster 2 Brain Map - Barres 6.612E-10 7.670E-8 6.723E-7 2.378E-6 14 135
32 GSM854338 500 Myeloid Cells, GN.Arth.SynF, CD11b+ Ly6-G+, Synovial Fluid, avg-3 Immgen.org, GSE15907 8.740E-10 9.822E-8 8.609E-7 3.143E-6 23 418
33 gudmap kidney adult RenCorpuscGlomer k1 200 kidney adult RenCorpuscGlomer k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.450E-9 1.580E-7 1.385E-6 5.213E-6 8 30
34 gudmap kidney adult RenCorpuscGlomer 200 kidney adult RenCorpuscGlomer top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.832E-9 1.937E-7 1.698E-6 6.587E-6 15 172
35 endothelial SubClass MFSD2-hi Top 500 Cluster 1 endothelial SubClass MFSD2-hi Top 500 Cluster 1 Brain Map - Barres 2.439E-9 2.435E-7 2.134E-6 8.771E-6 18 265
36 GSM538309 500 NK cells, NK.MCMV1.Sp, CD3-,NK1.1+, Spleen, avg-3 Immgen.org, GSE15907 2.442E-9 2.435E-7 2.134E-6 8.781E-6 21 367
37 GSM854269 500 Myeloid Cells, DC.103-11b+24+.Lu, MHCII+ CD11c+ CD103- CD11b+ CD24+, Lung, avg-2 Immgen.org, GSE15907 2.505E-9 2.435E-7 2.134E-6 9.009E-6 22 404
38 GSM538300 500 NK cells, NK.H+.MCMV1.Sp, NK1.1+ TCRb- Ly49H+, Spleen, avg-3 Immgen.org, GSE15907 2.822E-9 2.671E-7 2.341E-6 1.015E-5 21 370
39 gudmap kidney adult CortVasc Tie2 k2 1000 kidney adult CortVasc Tie2 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.089E-9 2.849E-7 2.497E-6 1.111E-5 19 302
40 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.285E-9 2.953E-7 2.589E-6 1.181E-5 22 410
41 microglia Top 500 All microglia Top 500 All Brain Map - Barres 3.866E-9 3.391E-7 2.972E-6 1.390E-5 24 491
42 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 4.354E-9 3.728E-7 3.267E-6 1.566E-5 24 494
43 gudmap kidney adult RenCorpuscGlomer 100 kidney adult RenCorpuscGlomer top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 4.994E-9 4.177E-7 3.661E-6 1.796E-5 11 86
44 gudmap RNAseq e15.5 Endothelial 2500 K4 gudmap RNAseq e15.5 Endothelial 2500 K4 Gudmap RNAseq 7.665E-9 6.264E-7 5.491E-6 2.756E-5 18 285
45 GSM605761 500 alpha beta T cells, T.4.Sp.B16, 4+ 8- TCR+ 45+, B16 Melanoma Spleen, avg-2 Immgen.org, GSE15907 8.812E-9 6.941E-7 6.084E-6 3.169E-5 19 322
46 gudmap dev gonad e11.5 M GonMes Sma 500 dev gonad e11.5 M GonMes Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.880E-9 6.941E-7 6.084E-6 3.193E-5 22 433
47 gudmap dev gonad e11.5 F GonMes Sma 500 dev gonad e11.5 F GonMes Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.048E-8 8.021E-7 7.030E-6 3.770E-5 22 437
48 GSM854276 500 Myeloid Cells, DC.11cloSer.Salm3.SI, CD45+ MHCII+ Gr1- CD11c-lo CD11b+, Small Intestine, avg-4 Immgen.org, GSE15907 1.180E-8 8.839E-7 7.747E-6 4.243E-5 20 364
49 gudmap kidney adult RenMedVasc Tie2 k2 500 kidney adult RenMedVasc Tie2 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.248E-8 9.159E-7 8.028E-6 4.488E-5 14 169
50 GSM605820 500 Myeloid Cells, DC.103+11b-.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3 Immgen.org, GSE15907 2.876E-8 2.069E-6 1.813E-5 1.034E-4 20 384
Show 45 more annotations

15: Computational [Display Chart] 422 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 44 Genes in module 44 MSigDb: C4 - CM: Cancer Modules 9.491E-10 3.528E-7 2.337E-6 4.005E-7 24 319
2 module 345 Genes in module 345 MSigDb: C4 - CM: Cancer Modules 2.047E-9 3.528E-7 2.337E-6 8.636E-7 15 121
3 module 75 Genes in module 75 MSigDb: C4 - CM: Cancer Modules 2.508E-9 3.528E-7 2.337E-6 1.058E-6 26 391
4 module 436 Genes in module 436 MSigDb: C4 - CM: Cancer Modules 7.699E-9 8.123E-7 5.380E-6 3.249E-6 15 133
5 module 12 Genes in module 12 MSigDb: C4 - CM: Cancer Modules 1.375E-7 1.161E-5 7.688E-5 5.804E-5 22 351
6 module 46 Genes in module 46 MSigDb: C4 - CM: Cancer Modules 1.738E-7 1.222E-5 8.097E-5 7.335E-5 23 386
7 module 171 Genes in module 171 MSigDb: C4 - CM: Cancer Modules 4.371E-7 2.635E-5 1.745E-4 1.845E-4 13 133
8 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 9.316E-7 4.914E-5 3.255E-4 3.931E-4 21 361
9 module 2 Genes in module 2 MSigDb: C4 - CM: Cancer Modules 1.957E-6 9.176E-5 6.078E-4 8.258E-4 21 378
10 module 208 Genes in module 208 MSigDb: C4 - CM: Cancer Modules 6.527E-6 2.755E-4 1.824E-3 2.755E-3 11 120
11 module 312 Genes in module 312 MSigDb: C4 - CM: Cancer Modules 1.038E-5 3.984E-4 2.639E-3 4.382E-3 7 45
12 module 118 Genes in module 118 MSigDb: C4 - CM: Cancer Modules 1.402E-5 4.930E-4 3.265E-3 5.916E-3 20 395
13 module 292 Genes in module 292 MSigDb: C4 - CM: Cancer Modules 1.629E-5 5.289E-4 3.503E-3 6.876E-3 11 132
14 module 5 Genes in module 5 MSigDb: C4 - CM: Cancer Modules 3.761E-5 1.134E-3 7.508E-3 1.587E-2 20 423
15 module 128 Genes in module 128 MSigDb: C4 - CM: Cancer Modules 4.559E-5 1.283E-3 8.495E-3 1.924E-2 9 98
16 module 170 Genes in module 170 MSigDb: C4 - CM: Cancer Modules 5.352E-5 1.328E-3 8.799E-3 2.258E-2 9 100
17 module 79 Genes in module 79 MSigDb: C4 - CM: Cancer Modules 5.352E-5 1.328E-3 8.799E-3 2.258E-2 9 100
18 module 254 Genes in module 254 MSigDb: C4 - CM: Cancer Modules 5.703E-5 1.337E-3 8.855E-3 2.407E-2 7 58
19 module 456 Genes in module 456 MSigDb: C4 - CM: Cancer Modules 1.051E-4 2.272E-3 1.505E-2 4.436E-2 9 109
20 module 15 Genes in module 15 MSigDb: C4 - CM: Cancer Modules 1.077E-4 2.272E-3 1.505E-2 4.543E-2 17 350
21 module 177 Genes in module 177 MSigDb: C4 - CM: Cancer Modules 3.403E-4 6.839E-3 4.530E-2
1.436E-1
 8 101
22 module 199 Genes in module 199 MSigDb: C4 - CM: Cancer Modules 4.194E-4 8.044E-3
5.328E-2
1.770E-1
 6 57
23 module 259 Genes in module 259 MSigDb: C4 - CM: Cancer Modules 1.108E-3 2.033E-2
1.346E-1
4.675E-1
 5 46
24 module 47 Genes in module 47 MSigDb: C4 - CM: Cancer Modules 1.256E-3 2.128E-2
1.410E-1
5.301E-1
 11 216
25 module 488 Genes in module 488 MSigDb: C4 - CM: Cancer Modules 1.261E-3 2.128E-2
1.410E-1
5.321E-1
 4 28
26 module 112 Genes in module 112 MSigDb: C4 - CM: Cancer Modules 1.604E-3 2.604E-2
1.724E-1
6.769E-1
 12 257
27 module 60 Genes in module 60 MSigDb: C4 - CM: Cancer Modules 1.861E-3 2.833E-2
1.876E-1
7.854E-1
 16 410
28 module 33 Genes in module 33 MSigDb: C4 - CM: Cancer Modules 1.880E-3 2.833E-2
1.876E-1
7.933E-1
 15 372
29 module 52 Genes in module 52 MSigDb: C4 - CM: Cancer Modules 2.319E-3 3.374E-2
2.235E-1
9.785E-1
 16 419
30 GNF2 CD53 Neighborhood of CD53 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.483E-3 3.414E-2
2.261E-1
1.000E0
 5 55
31 module 27 Genes in module 27 MSigDb: C4 - CM: Cancer Modules 2.508E-3 3.414E-2
2.261E-1
1.000E0
 14 345
32 module 53 Genes in module 53 MSigDb: C4 - CM: Cancer Modules 3.034E-3 4.001E-2
2.650E-1
1.000E0
 15 391
33 GNF2 CD97 Neighborhood of CD97 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.606E-3 4.612E-2
3.055E-1
1.000E0
 4 37
Show 28 more annotations

16: MicroRNA [Display Chart] 1370 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-641:PITA hsa-miR-641:PITA TOP PITA 5.562E-8 7.619E-5 5.943E-4 7.619E-5 23 490
2 hsa-miR-448:PITA hsa-miR-448:PITA TOP PITA 6.545E-7 4.483E-4 3.497E-3 8.967E-4 20 438
3 TATTATA,MIR-374:MSigDB TATTATA,MIR-374:MSigDB MSigDB 6.625E-6 2.202E-3 1.717E-2 9.077E-3 14 266
4 miR-9-star:PicTar miR-9-star:PicTar PicTar 7.037E-6 2.202E-3 1.717E-2 9.641E-3 15 305
5 miR-101:PicTar miR-101:PicTar PicTar 8.035E-6 2.202E-3 1.717E-2 1.101E-2 18 430
6 hsa-miR-136:PITA hsa-miR-136:PITA TOP PITA 2.157E-5 4.893E-3 3.816E-2 2.955E-2 13 257
7 hsa-miR-33b:TargetScan hsa-miR-33b:TargetScan TargetScan 2.857E-5 4.893E-3 3.816E-2 3.914E-2 13 264
8 hsa-miR-33a:TargetScan hsa-miR-33a:TargetScan TargetScan 2.857E-5 4.893E-3 3.816E-2 3.914E-2 13 264
9 miR-144:PicTar miR-144:PicTar PicTar 3.254E-5 4.954E-3 3.864E-2 4.459E-2 17 433
10 hsa-miR-4292:mirSVR highEffct hsa-miR-4292:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.327E-5 5.928E-3 4.624E-2
5.928E-2
 16 399
11 GTAAGAT,MIR-200A:MSigDB GTAAGAT,MIR-200A:MSigDB MSigDB 5.482E-5 6.323E-3 4.932E-2
7.511E-2
 6 54
12 ATACCTC,MIR-202:MSigDB ATACCTC,MIR-202:MSigDB MSigDB 5.539E-5 6.323E-3 4.932E-2
7.588E-2
 10 170
13 hsa-miR-590-5p:TargetScan hsa-miR-590-5p:TargetScan TargetScan 6.511E-5 6.371E-3 4.970E-2
8.920E-2
 11 209
14 hsa-miR-21:TargetScan hsa-miR-21:TargetScan TargetScan 6.511E-5 6.371E-3 4.970E-2
8.920E-2
 11 209
15 miR-199a-star:PicTar miR-199a-star:PicTar PicTar 8.374E-5 7.648E-3
5.966E-2
1.147E-1
 16 422
16 hsa-miR-216b:PITA hsa-miR-216b:PITA TOP PITA 9.267E-5 7.935E-3
6.189E-2
1.270E-1
 14 338
17 ACAACCT,MIR-453:MSigDB ACAACCT,MIR-453:MSigDB MSigDB 1.491E-4 1.145E-2
8.927E-2
2.043E-1
 5 41
18 miR-32:PicTar miR-32:PicTar PicTar 1.504E-4 1.145E-2
8.927E-2
2.060E-1
 16 444
19 hsa-miR-452:PITA hsa-miR-452:PITA TOP PITA 1.796E-4 1.295E-2
1.010E-1
2.460E-1
 16 451
20 miR-193b:PicTar miR-193b:PicTar PicTar 2.008E-4 1.375E-2
1.073E-1
2.750E-1
 9 162
21 hsa-miR-100:mirSVR lowEffct hsa-miR-100:mirSVR conserved lowEffect-0.1-0.5 MicroRNA.org 2.207E-4 1.440E-2
1.123E-1
3.023E-1
 10 201
22 hsa-miR-491-3p:PITA hsa-miR-491-3p:PITA TOP PITA 2.687E-4 1.659E-2
1.294E-1
3.681E-1
 12 287
23 GACAATC,MIR-219:MSigDB GACAATC,MIR-219:MSigDB MSigDB 2.785E-4 1.659E-2
1.294E-1
3.815E-1
 8 134
24 miR-323:PicTar miR-323:PicTar PicTar 2.922E-4 1.668E-2
1.301E-1
4.003E-1
 11 248
25 miR-335:PicTar miR-335:PicTar PicTar 3.079E-4 1.680E-2
1.311E-1
4.218E-1
 8 136
26 miR-367:PicTar miR-367:PicTar PicTar 3.189E-4 1.680E-2
1.311E-1
4.369E-1
 13 336
27 CTTTGCA,MIR-527:MSigDB CTTTGCA,MIR-527:MSigDB MSigDB 4.063E-4 2.062E-2
1.608E-1
5.567E-1
 10 217
28 hsa-miR-7:TargetScan hsa-miR-7:TargetScan TargetScan 4.255E-4 2.082E-2
1.624E-1
5.829E-1
 12 302
29 CATTTCA,MIR-203:MSigDB CATTTCA,MIR-203:MSigDB MSigDB 4.955E-4 2.240E-2
1.747E-1
6.788E-1
 11 264
30 ACTGTGA,MIR-27B:MSigDB ACTGTGA,MIR-27B:MSigDB MSigDB 5.110E-4 2.240E-2
1.747E-1
7.001E-1
 15 447
31 ACTGTGA,MIR-27A:MSigDB ACTGTGA,MIR-27A:MSigDB MSigDB 5.110E-4 2.240E-2
1.747E-1
7.001E-1
 15 447
32 hsa-miR-591:mirSVR highEffct hsa-miR-591:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.351E-4 2.240E-2
1.747E-1
7.331E-1
 15 449
33 TAGCTTT,MIR-9:MSigDB TAGCTTT,MIR-9:MSigDB MSigDB 5.395E-4 2.240E-2
1.747E-1
7.391E-1
 10 225
34 ATAAGCT,MIR-21:MSigDB ATAAGCT,MIR-21:MSigDB MSigDB 6.270E-4 2.527E-2
1.971E-1
8.591E-1
 7 116
35 hsa-miR-7:PITA hsa-miR-7:PITA TOP PITA 6.615E-4 2.589E-2
2.020E-1
9.062E-1
 10 231
36 hsa-miR-31:TargetScan hsa-miR-31:TargetScan TargetScan 6.839E-4 2.603E-2
2.030E-1
9.369E-1
 10 232
37 GTTTGTT,MIR-495:MSigDB GTTTGTT,MIR-495:MSigDB MSigDB 7.798E-4 2.887E-2
2.252E-1
1.000E0
 10 236
38 hsa-miR-125a-5p:mirSVR highEffct hsa-miR-125a-5p:mirSVR conserved highEffect-0.5 MicroRNA.org 8.712E-4 3.141E-2
2.450E-1
1.000E0
 15 471
39 miR-203:PicTar miR-203:PicTar PicTar 9.269E-4 3.199E-2
2.495E-1
1.000E0
 12 330
40 hsa-miR-933:mirSVR lowEffct hsa-miR-933:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 9.346E-4 3.199E-2
2.495E-1
1.000E0
 13 377
41 hsa-miR-1284:PITA hsa-miR-1284:PITA TOP PITA 9.767E-4 3.199E-2
2.495E-1
1.000E0
 14 427
42 hsa-miR-34b:PITA hsa-miR-34b:PITA TOP PITA 9.807E-4 3.199E-2
2.495E-1
1.000E0
 13 379
43 ATGCTGC,MIR-103:MSigDB ATGCTGC,MIR-103:MSigDB MSigDB 1.033E-3 3.217E-2
2.509E-1
1.000E0
 9 203
44 ATGCTGC,MIR-107:MSigDB ATGCTGC,MIR-107:MSigDB MSigDB 1.033E-3 3.217E-2
2.509E-1
1.000E0
 9 203
45 hsa-miR-323-3p:PITA hsa-miR-323-3p:PITA TOP PITA 1.104E-3 3.267E-2
2.548E-1
1.000E0
 13 384
46 hsa-miR-603:PITA hsa-miR-603:PITA TOP PITA 1.130E-3 3.267E-2
2.548E-1
1.000E0
 13 385
47 hsa-miR-576-5p:PITA hsa-miR-576-5p:PITA TOP PITA 1.140E-3 3.267E-2
2.548E-1
1.000E0
 14 434
48 hsa-miR-4319:mirSVR highEffct hsa-miR-4319:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.191E-3 3.267E-2
2.548E-1
1.000E0
 14 436
49 hsa-miR-125b:mirSVR highEffct hsa-miR-125b:mirSVR conserved highEffect-0.5 MicroRNA.org 1.191E-3 3.267E-2
2.548E-1
1.000E0
 14 436
50 hsa-miR-549:PITA hsa-miR-549:PITA TOP PITA 1.192E-3 3.267E-2
2.548E-1
1.000E0
 8 167
Show 45 more annotations

17: Drug [Display Chart] 24614 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1297 UP Suloctidil [54063-56-8]; Up 200; 11.8uM; HL60; HT HG-U133A Broad Institute CMAP 2.726E-25 6.710E-21 7.172E-20 6.710E-21 28 161
2 5010 UP Prochlorperazine dimaleate [84-02-6]; Up 200; 6.6uM; MCF7; HT HG-U133A Broad Institute CMAP 4.482E-20 5.516E-16 5.895E-15 1.103E-15 25 182
3 1626 UP Etoposide [33419-42-0]; Up 200; 6.8uM; HL60; HG-U133A Broad Institute CMAP 8.691E-20 7.130E-16 7.621E-15 2.139E-15 24 167
4 1737 UP Prenylamine lactate [69-43-2]; Up 200; 9.6uM; HL60; HG-U133A Broad Institute CMAP 1.278E-17 7.866E-14 8.408E-13 3.146E-13 23 184
5 2448 UP Puromycin dihydrochloride [58-58-2]; Up 200; 7.4uM; HL60; HT HG-U133A Broad Institute CMAP 3.740E-17 1.841E-13 1.968E-12 9.205E-13 21 151
6 4707 UP Mephentermine hemisulfate [1212-72-2]; Up 200; 9.4uM; MCF7; HT HG-U133A Broad Institute CMAP 2.197E-16 9.013E-13 9.634E-12 5.408E-12 22 186
7 1381 UP Terfenadine [50679-08-8]; Up 200; 8.4uM; HL60; HG-U133A Broad Institute CMAP 7.403E-15 2.603E-11 2.782E-10 1.822E-10 20 172
8 1304 UP Anisomycin [22862-76-6]; Up 200; 15uM; HL60; HT HG-U133A Broad Institute CMAP 1.698E-14 5.225E-11 5.584E-10 4.180E-10 19 157
9 5490 UP Niflumic acid [4394-00-7]; Up 200; 14.2uM; MCF7; HT HG-U133A Broad Institute CMAP 4.139E-14 1.132E-10 1.210E-9 1.019E-9 20 188
10 2938 UP Alprostadil [745-65-3]; Up 200; 11.2uM; HL60; HT HG-U133A Broad Institute CMAP 5.413E-14 1.332E-10 1.424E-9 1.332E-9 18 145
11 4146 UP Selegiline hydrochloride [14611-52-0]; Up 200; 17.8uM; MCF7; HT HG-U133A Broad Institute CMAP 7.557E-14 1.691E-10 1.807E-9 1.860E-9 20 194
12 D010081 Oxazolone CTD 1.398E-13 2.867E-10 3.065E-9 3.441E-9 22 253
13 5306 UP Propofol [2078-54-8]; Up 200; 22.4uM; MCF7; HT HG-U133A Broad Institute CMAP 2.108E-13 3.990E-10 4.265E-9 5.187E-9 19 180
14 2338 UP Mebendazole [31431-39-7]; Up 200; 13.6uM; HL60; HT HG-U133A Broad Institute CMAP 2.450E-13 4.308E-10 4.604E-9 6.031E-9 18 158
15 1833 UP Azaguanine-8 [134-58-7]; Up 200; 26.2uM; HL60; HT HG-U133A Broad Institute CMAP 2.735E-13 4.489E-10 4.798E-9 6.733E-9 18 159
16 1829 UP Acetohexamide [968-81-0]; Up 200; 12.4uM; PC3; HT HG-U133A Broad Institute CMAP 6.792E-13 1.045E-9 1.117E-8 1.672E-8 19 192
17 2423 UP Digoxin [20830-75-5]; Up 200; 5.2uM; HL60; HT HG-U133A Broad Institute CMAP 8.738E-13 1.265E-9 1.352E-8 2.151E-8 18 170
18 2690 UP thioridazine hydrochloride; Up 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP 1.750E-12 2.393E-9 2.558E-8 4.308E-8 18 177
19 1171 UP thioridazine hydrochloride; Up 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP 2.334E-12 3.024E-9 3.232E-8 5.746E-8 18 180
20 1613 UP Clenbuterol hydrochloride [21898-19-1]; Up 200; 12.8uM; HL60; HG-U133A Broad Institute CMAP 2.566E-12 3.158E-9 3.376E-8 6.317E-8 18 181
21 6149 UP (-)-Isoproterenol hydrochloride [5984-95-2]; Up 200; 16.2uM; HL60; HT HG-U133A Broad Institute CMAP 5.404E-12 6.334E-9 6.770E-8 1.330E-7 17 164
22 5005 UP Clorgyline hydrochloride [17780-75-5]; Up 200; 13uM; MCF7; HT HG-U133A Broad Institute CMAP 7.647E-12 8.555E-9 9.144E-8 1.882E-7 18 193
23 6202 UP wortmannin from Penicillium funiculosum; Up 200; 0.01uM; HL60; HT HG-U133A Broad Institute CMAP 1.178E-11 1.260E-8 1.347E-7 2.899E-7 18 198
24 D008775 Methylprednisolone CTD 1.877E-11 1.925E-8 2.057E-7 4.620E-7 15 129
25 1786 UP Chelidonine monohydrate (+) [476-32-4]; Up 200; 10.8uM; HL60; HG-U133A Broad Institute CMAP 2.466E-11 2.428E-8 2.595E-7 6.070E-7 16 155
26 D006052 Gold Sodium Thiomalate CTD 3.500E-11 3.313E-8 3.541E-7 8.614E-7 13 92
27 2457 UP Hexetidine [141-94-6]; Up 200; 11.8uM; HL60; HT HG-U133A Broad Institute CMAP 3.757E-11 3.425E-8 3.661E-7 9.248E-7 17 185
28 5019 UP Dehydroisoandosterone 3-acetate [853-23-6]; Up 200; 12.2uM; MCF7; HT HG-U133A Broad Institute CMAP 4.853E-11 4.266E-8 4.560E-7 1.195E-6 17 188
29 C007020 chlorophyllin CTD 6.079E-11 5.160E-8 5.515E-7 1.496E-6 13 96
30 CID000032744 polyinosinic-polycytidylic acid Stitch 1.351E-10 1.108E-7 1.184E-6 3.325E-6 20 291
31 C483909 torcetrapib CTD 1.706E-10 1.355E-7 1.448E-6 4.200E-6 21 328
32 5234 UP fluphenazine dihydrochloride; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.995E-10 1.535E-7 1.641E-6 4.912E-6 16 178
33 2429 UP Cephaeline dihydrochloride heptahydrate [6487-30-5]; Up 200; 6uM; HL60; HT HG-U133A Broad Institute CMAP 4.126E-10 3.009E-7 3.216E-6 1.015E-5 15 160
34 2684 UP trifluoperazine dihydrochloride; Up 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP 4.156E-10 3.009E-7 3.216E-6 1.023E-5 16 187
35 2145 UP Emetine dihydrochloride [316-42-7]; Up 200; 7.2uM; HL60; HT HG-U133A Broad Institute CMAP 5.359E-10 3.769E-7 4.028E-6 1.319E-5 15 163
36 4367 UP (1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP 5.683E-10 3.886E-7 4.153E-6 1.399E-5 16 191
37 6846 UP Metoprolol-(+,-) (+)-tartrate salt [56392-17-7]; Up 200; 5.8uM; MCF7; HT HG-U133A Broad Institute CMAP 6.626E-10 4.408E-7 4.712E-6 1.631E-5 16 193
38 6242 UP Skimmianine [83-95-4]; Up 200; 15.4uM; MCF7; HT HG-U133A Broad Institute CMAP 7.150E-10 4.630E-7 4.949E-6 1.760E-5 16 194
39 2927 UP Sanguinarine [2447-54-3]; Up 200; 12uM; HL60; HT HG-U133A Broad Institute CMAP 7.530E-10 4.630E-7 4.949E-6 1.853E-5 15 167
40 1745 UP Dihydroergocristine mesylate [24730-10-7]; Up 200; 5.6uM; HL60; HG-U133A Broad Institute CMAP 7.530E-10 4.630E-7 4.949E-6 1.853E-5 15 167
41 5313 UP Hesperidin [520-26-3]; Up 200; 6.6uM; MCF7; HT HG-U133A Broad Institute CMAP 7.712E-10 4.630E-7 4.949E-6 1.898E-5 16 195
42 CID000134928 4-methylumbelliferyl phenylphosphonate Stitch 1.038E-9 5.863E-7 6.267E-6 2.554E-5 5 6
43 3576 UP Thiethylperazine malate [52239-63-1]; Up 200; 6uM; MCF7; HT HG-U133A Broad Institute CMAP 1.039E-9 5.863E-7 6.267E-6 2.557E-5 16 199
44 2957 UP Pyrvinium pamoate [3546-41-6]; Up 200; 3.4uM; HL60; HT HG-U133A Broad Institute CMAP 1.048E-9 5.863E-7 6.267E-6 2.580E-5 15 171
45 3295 UP Felodipine [72509-76-3]; Up 200; 10.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.446E-9 7.737E-7 8.270E-6 3.559E-5 15 175
46 3746 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.446E-9 7.737E-7 8.270E-6 3.559E-5 15 175
47 4164 UP Thioridazine hydrochloride [130-61-0]; Up 200; 9.8uM; MCF7; HT HG-U133A Broad Institute CMAP 1.693E-9 8.866E-7 9.476E-6 4.167E-5 15 177
48 1477 UP Miconazole [22916-47-8]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP 2.136E-9 1.095E-6 1.171E-5 5.258E-5 15 180
49 1520 UP Azacyclonol [115-46-8]; Up 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 2.397E-9 1.204E-6 1.287E-5 5.901E-5 14 154
50 CID000107918 oligoadenylate Stitch 3.085E-9 1.519E-6 1.623E-5 7.593E-5 14 157
Show 45 more annotations

18: Disease [Display Chart] 2346 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0021400 Influenza DisGeNET Curated 1.442E-11 3.384E-8 2.821E-7 3.384E-8 29 484
2 umls:C1096184 West Nile viral infection DisGeNET BeFree 9.879E-7 1.159E-3 9.662E-3 2.318E-3 9 78
3 umls:C0701807 Acute anterior uveitis DisGeNET BeFree 1.924E-5 1.504E-2
1.254E-1
 4.513E-2 6 42