Toppgene analysis for aggregated_1964_log, IC11, positive side

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1: GO: Molecular Function [Display Chart] 155 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003777 microtubule motor activity 4.159E-10 6.447E-8 3.626E-7 6.447E-8 7 77
2 GO:0003774 motor activity 1.858E-8 1.440E-6 8.100E-6 2.881E-6 7 132
3 GO:0016887 ATPase activity 4.968E-4 2.567E-2
1.443E-1
7.700E-2
 6 446

2: GO: Biological Process [Display Chart] 688 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007018 microtubule-based movement 6.834E-8 4.702E-5 3.344E-4 4.702E-5 8 237
2 GO:0003341 cilium movement 8.183E-6 2.815E-3 2.002E-2 5.630E-3 4 55
3 GO:0001539 cilium or flagellum-dependent cell motility 2.345E-5 5.377E-3 3.824E-2 1.613E-2 3 24
4 GO:0035418 protein localization to synapse 4.198E-5 6.876E-3 4.890E-2 2.889E-2 3 29
5 GO:0007525 somatic muscle development 5.338E-5 6.876E-3 4.890E-2 3.673E-2 2 5
6 GO:0097114 NMDA glutamate receptor clustering 7.995E-5 6.876E-3 4.890E-2
5.501E-2
 2 6
7 GO:0097107 postsynaptic density assembly 7.995E-5 6.876E-3 4.890E-2
5.501E-2
 2 6
8 GO:0097106 postsynaptic density organization 7.995E-5 6.876E-3 4.890E-2
5.501E-2
 2 6
9 GO:0098598 learned vocalization behavior or vocal learning 1.118E-4 6.990E-3 4.971E-2
7.689E-2
 2 7
10 GO:0098596 imitative learning 1.118E-4 6.990E-3 4.971E-2
7.689E-2
 2 7
11 GO:0042297 vocal learning 1.118E-4 6.990E-3 4.971E-2
7.689E-2
 2 7
12 GO:0098597 observational learning 1.910E-4 1.011E-2
7.190E-2
1.314E-1
 2 9
13 GO:1904861 excitatory synapse assembly 1.910E-4 1.011E-2
7.190E-2
1.314E-1
 2 9
14 GO:0031223 auditory behavior 2.384E-4 1.052E-2
7.479E-2
1.640E-1
 2 10
15 GO:0097119 postsynaptic density protein 95 clustering 2.384E-4 1.052E-2
7.479E-2
1.640E-1
 2 10
16 GO:0035082 axoneme assembly 2.446E-4 1.052E-2
7.479E-2
1.683E-1
 3 52
17 GO:0090129 positive regulation of synapse maturation 2.910E-4 1.091E-2
7.760E-2
2.002E-1
 2 11
18 GO:0072578 neurotransmitter-gated ion channel clustering 2.910E-4 1.091E-2
7.760E-2
2.002E-1
 2 11
19 GO:0051668 localization within membrane 3.013E-4 1.091E-2
7.760E-2
2.073E-1
 4 138
20 GO:0007638 mechanosensory behavior 4.114E-4 1.313E-2
9.338E-2
2.831E-1
 2 13
21 GO:0097120 receptor localization to synapse 4.114E-4 1.313E-2
9.338E-2
2.831E-1
 2 13
22 GO:0007611 learning or memory 4.199E-4 1.313E-2
9.338E-2
2.889E-1
 5 272
23 GO:0090128 regulation of synapse maturation 4.793E-4 1.434E-2
1.020E-1
3.297E-1
 2 14
24 GO:0007612 learning 5.660E-4 1.622E-2
1.154E-1
3.894E-1
 4 163
25 GO:2000310 regulation of NMDA receptor activity 6.301E-4 1.734E-2
1.233E-1
4.335E-1
 2 16
26 GO:0050890 cognition 6.955E-4 1.834E-2
1.304E-1
4.785E-1
 5 304
27 GO:0007215 glutamate receptor signaling pathway 7.197E-4 1.834E-2
1.304E-1
4.952E-1
 3 75
28 GO:0001578 microtubule bundle formation 8.374E-4 2.058E-2
1.463E-1
5.761E-1
 3 79
29 GO:2000311 regulation of AMPA receptor activity 1.095E-3 2.597E-2
1.847E-1
7.531E-1
 2 21
30 GO:0060074 synapse maturation 1.202E-3 2.757E-2
1.961E-1
8.271E-1
 2 22
31 GO:0010996 response to auditory stimulus 1.315E-3 2.918E-2
2.075E-1
9.046E-1
 2 23
32 GO:0051968 positive regulation of synaptic transmission, glutamatergic 1.432E-3 3.079E-2
2.190E-1
9.853E-1
 2 24
33 GO:2000463 positive regulation of excitatory postsynaptic potential 1.681E-3 3.506E-2
2.493E-1
1.000E0
 2 26
34 GO:0007527 adult somatic muscle development 2.342E-3 4.035E-2
2.869E-1
1.000E0
 1 1
35 GO:0021758 putamen development 2.342E-3 4.035E-2
2.869E-1
1.000E0
 1 1
36 GO:0090126 protein complex assembly involved in synapse maturation 2.342E-3 4.035E-2
2.869E-1
1.000E0
 1 1
37 GO:1902076 regulation of lateral motor column neuron migration 2.342E-3 4.035E-2
2.869E-1
1.000E0
 1 1
38 GO:0021757 caudate nucleus development 2.342E-3 4.035E-2
2.869E-1
1.000E0
 1 1
39 GO:1902078 positive regulation of lateral motor column neuron migration 2.342E-3 4.035E-2
2.869E-1
1.000E0
 1 1
40 GO:0021549 cerebellum development 2.346E-3 4.035E-2
2.869E-1
1.000E0
 3 113
41 GO:0007616 long-term memory 2.543E-3 4.069E-2
2.894E-1
1.000E0
 2 32
42 GO:0021591 ventricular system development 2.543E-3 4.069E-2
2.894E-1
1.000E0
 2 32
43 GO:1900449 regulation of glutamate receptor signaling pathway 2.543E-3 4.069E-2
2.894E-1
1.000E0
 2 32
44 GO:0021987 cerebral cortex development 2.848E-3 4.290E-2
3.051E-1
1.000E0
 3 121
45 GO:0001941 postsynaptic membrane organization 2.868E-3 4.290E-2
3.051E-1
1.000E0
 2 34
46 GO:0099601 regulation of neurotransmitter receptor activity 2.868E-3 4.290E-2
3.051E-1
1.000E0
 2 34
47 GO:0060541 respiratory system development 3.066E-3 4.458E-2
3.170E-1
1.000E0
 4 258
48 GO:0022037 metencephalon development 3.122E-3 4.458E-2
3.170E-1
1.000E0
 3 125
49 GO:0098815 modulation of excitatory postsynaptic potential 3.211E-3 4.458E-2
3.170E-1
1.000E0
 2 36
50 GO:0021537 telencephalon development 3.240E-3 4.458E-2
3.170E-1
1.000E0
 4 262
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 169 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030286 dynein complex 1.022E-11 1.727E-9 9.859E-9 1.727E-9 7 45
2 GO:0044447 axoneme part 4.285E-11 3.621E-9 2.067E-8 7.241E-9 6 28
3 GO:0005858 axonemal dynein complex 3.432E-10 1.933E-8 1.104E-7 5.800E-8 5 17
4 GO:0097014 ciliary plasm 3.051E-9 1.031E-7 5.889E-7 5.156E-7 7 99
5 GO:0005930 axoneme 3.051E-9 1.031E-7 5.889E-7 5.156E-7 7 99
6 GO:0044441 ciliary part 8.115E-9 2.286E-7 1.305E-6 1.371E-6 10 358
7 GO:0005875 microtubule associated complex 7.223E-8 1.744E-6 9.958E-6 1.221E-5 7 156
8 GO:0036156 inner dynein arm 4.202E-7 8.876E-6 5.068E-5 7.101E-5 3 7
9 GO:0005874 microtubule 5.654E-5 1.062E-3 6.062E-3 9.554E-3 7 427
10 GO:0036157 outer dynein arm 1.495E-4 2.526E-3 1.443E-2 2.526E-2 2 8
11 GO:0005578 proteinaceous extracellular matrix 1.876E-3 2.883E-2
1.646E-1
3.171E-1
 5 379
12 GO:1990718 axonemal central pair projection 2.347E-3 3.306E-2
1.888E-1
3.967E-1
 1 1
13 GO:0031012 extracellular matrix 3.713E-3 4.827E-2
2.756E-1
6.276E-1
 5 444
Show 8 more annotations

4: Human Phenotype [Display Chart] 205 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0100582 Nasal polyposis 1.414E-5 2.899E-3 1.711E-2 2.899E-3 3 15
2 HP:0001334 Communicating hydrocephalus 1.074E-4 6.590E-3 3.890E-2 2.201E-2 2 5
3 HP:0012265 Ciliary dyskinesia 1.352E-4 6.590E-3 3.890E-2 2.772E-2 3 31
4 HP:0005938 Abnormal respiratory motile cilium morphology 1.607E-4 6.590E-3 3.890E-2 3.295E-2 2 6
5 HP:0000481 Abnormality of the cornea 1.607E-4 6.590E-3 3.890E-2 3.295E-2 2 6
6 HP:0002257 Chronic rhinitis 2.989E-4 1.021E-2
6.027E-2
6.127E-2
 2 8
7 HP:0012263 Immotile cilia 3.835E-4 1.090E-2
6.432E-2
7.862E-2
 2 9
8 HP:0002688 Absent frontal sinuses 4.784E-4 1.090E-2
6.432E-2
9.808E-2
 2 10
9 HP:0000389 Chronic otitis media 4.784E-4 1.090E-2
6.432E-2
9.808E-2
 2 10
10 HP:0002110 Bronchiectasis 7.118E-4 1.459E-2
8.613E-2
1.459E-1
 3 54
11 HP:0001746 Asplenia 1.105E-3 2.060E-2
1.216E-1
2.266E-1
 2 15
12 HP:0011109 Chronic sinusitis 1.261E-3 2.154E-2
1.271E-1
2.585E-1
 2 16
13 HP:0007737 Bone spicule pigmentation of the retina 1.981E-3 3.123E-2
1.844E-1
4.060E-1
 2 20
14 HP:0003251 Male infertility {has synonym type="layperson"} 2.185E-3 3.199E-2
1.888E-1
4.479E-1
 2 21
15 HP:0000246 Sinusitis 3.348E-3 3.320E-2
1.960E-1
6.864E-1
 2 26
16 HP:0006818 Type I lissencephaly 3.401E-3 3.320E-2
1.960E-1
6.973E-1
 1 1
17 HP:0007301 Oromotor apraxia 3.401E-3 3.320E-2
1.960E-1
6.973E-1
 1 1
18 HP:0009901 Crumpled ear {has synonym type="layperson"} 3.401E-3 3.320E-2
1.960E-1
6.973E-1
 1 1
19 HP:0002334 Abnormality of the cerebellar vermis 3.401E-3 3.320E-2
1.960E-1
6.973E-1
 1 1
20 HP:0008962 Calf muscle hypoplasia 3.401E-3 3.320E-2
1.960E-1
6.973E-1
 1 1
21 HP:0008453 Congenital kyphoscoliosis 3.401E-3 3.320E-2
1.960E-1
6.973E-1
 1 1
22 HP:0000458 Anosmia 4.158E-3 3.875E-2
2.287E-1
8.524E-1
 2 29
Show 17 more annotations

5: Mouse Phenotype [Display Chart] 879 annotations before applied cutoff / 9299 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0011055 abnormal respiratory motile cilium physiology 7.764E-7 5.030E-4 3.701E-3 6.825E-4 4 24
2 MP:0011083 lethality at weaning, complete penetrance 1.377E-6 5.030E-4 3.701E-3 1.211E-3 5 64
3 MP:0013209 abnormal motile cilium physiology 1.717E-6 5.030E-4 3.701E-3 1.509E-3 4 29
4 MP:0014200 abnormal respiratory epithelium physiology 6.451E-6 1.254E-3 9.226E-3 5.671E-3 4 40
5 MP:0013208 abnormal cilium physiology 7.133E-6 1.254E-3 9.226E-3 6.270E-3 4 41
6 MP:0011511 biventricular, ambiguous atrioventricular connection 9.391E-6 1.376E-3 1.012E-2 8.255E-3 2 2
7 MP:0008569 lethality at weaning 1.524E-5 1.914E-3 1.408E-2 1.340E-2 5 104
8 MP:0011510 biventricular, discordant atrioventricular connection 2.812E-5 3.090E-3 2.273E-2 2.472E-2 2 3
9 MP:0010808 right-sided stomach 5.282E-5 5.159E-3 3.795E-2 4.643E-2 3 24
10 MP:0000508 right-sided isomerism 6.757E-5 5.940E-3 4.369E-2
5.940E-2
 3 26
11 MP:0000852 small cerebellum 1.037E-4 7.664E-3
5.638E-2
9.113E-2
 5 155
12 MP:0010807 abnormal stomach position or orientation 1.046E-4 7.664E-3
5.638E-2
9.197E-2
 3 30
13 MP:0011254 superior-inferior ventricles 1.398E-4 8.776E-3
6.456E-2
1.229E-1
 2 6
14 MP:0011253 situs inversus with levocardia 1.398E-4 8.776E-3
6.456E-2
1.229E-1
 2 6
15 MP:0003283 abnormal digestive organ placement 1.669E-4 9.781E-3
7.196E-2
1.467E-1
 3 35
16 MP:0000470 abnormal stomach morphology 1.885E-4 1.010E-2
7.429E-2
1.657E-1
 5 176
17 MP:0008461 left atrial isomerism 1.953E-4 1.010E-2
7.429E-2
1.717E-1
 2 7
18 MP:0000644 dextrocardia 2.493E-4 1.202E-2
8.846E-2
2.192E-1
 3 40
19 MP:0011249 abdominal situs inversus 2.599E-4 1.202E-2
8.846E-2
2.285E-1
 2 8
20 MP:0001406 abnormal gait 2.931E-4 1.288E-2
9.476E-2
2.576E-1
 7 434
21 MP:0001872 sinus inflammation 3.335E-4 1.303E-2
9.587E-2
2.932E-1
 2 9
22 MP:0011890 increased circulating ferritin level 3.335E-4 1.303E-2
9.587E-2
2.932E-1
 2 9
23 MP:0002766 situs inversus 3.544E-4 1.303E-2
9.587E-2
3.115E-1
 3 45
24 MP:0000849 abnormal cerebellum morphology 3.558E-4 1.303E-2
9.587E-2
3.128E-1
 7 448
25 MP:0010853 abnormal lung position or orientation 4.033E-4 1.418E-2
1.043E-1
3.545E-1
 3 47
26 MP:0000847 abnormal metencephalon morphology 5.541E-4 1.873E-2
1.378E-1
4.871E-1
 7 482
27 MP:0006061 right atrial isomerism 6.079E-4 1.887E-2
1.388E-1
5.344E-1
 2 12
28 MP:0011250 abdominal situs ambiguus 6.079E-4 1.887E-2
1.388E-1
5.344E-1
 2 12
29 MP:0000877 abnormal Purkinje cell morphology 6.225E-4 1.887E-2
1.388E-1
5.472E-1
 5 228
30 MP:0006065 abnormal heart position or orientation 6.765E-4 1.982E-2
1.458E-1
5.947E-1
 3 56
31 MP:0011889 abnormal circulating ferritin level 7.171E-4 2.033E-2
1.496E-1
6.303E-1
 2 13
32 MP:0011683 dual inferior vena cava 8.350E-4 2.224E-2
1.636E-1
7.340E-1
 2 14
33 MP:0011649 immotile respiratory cilia 8.350E-4 2.224E-2
1.636E-1
7.340E-1
 2 14
34 MP:0000650 mesocardia 9.616E-4 2.486E-2
1.829E-1
8.452E-1
 2 15
35 MP:0000875 abnormal cerebellar Purkinje cell layer 1.014E-3 2.547E-2
1.874E-1
8.916E-1
 5 254
36 MP:0000439 enlarged cranium 1.097E-3 2.678E-2
1.970E-1
9.641E-1
 2 16
37 MP:0011003 reduced AMPA-mediated synaptic currents 1.241E-3 2.870E-2
2.111E-1
1.000E0
 2 17
38 MP:0010607 common atrioventricular valve 1.241E-3 2.870E-2
2.111E-1
1.000E0
 2 17
39 MP:0011252 situs inversus totalis 1.393E-3 3.140E-2
2.310E-1
1.000E0
 2 18
40 MP:0004133 heterotaxia 1.524E-3 3.332E-2
2.451E-1
1.000E0
 3 74
41 MP:0011050 abnormal respiratory motile cilium morphology 1.554E-3 3.332E-2
2.451E-1
1.000E0
 2 19
42 MP:0000531 right pulmonary isomerism 1.901E-3 3.979E-2
2.927E-1
1.000E0
 2 21
43 MP:0004017 duplex kidney 2.281E-3 4.664E-2
3.431E-1
1.000E0
 2 23
Show 38 more annotations

6: Domain [Display Chart] 398 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF12780 AAA 8 Pfam 9.580E-16 4.766E-14 3.129E-13 3.813E-13 7 14
2 PF12777 MT Pfam 9.580E-16 4.766E-14 3.129E-13 3.813E-13 7 14
3 PF07728 AAA 5 Pfam 9.580E-16 4.766E-14 3.129E-13 3.813E-13 7 14
4 IPR024317 Dynein heavy chain D4 dom InterPro 9.580E-16 4.766E-14 3.129E-13 3.813E-13 7 14
5 PF08393 DHC N2 Pfam 9.580E-16 4.766E-14 3.129E-13 3.813E-13 7 14
6 IPR013602 Dynein heavy dom-2 InterPro 9.580E-16 4.766E-14 3.129E-13 3.813E-13 7 14
7 IPR024743 Dynein HC stalk InterPro 9.580E-16 4.766E-14 3.129E-13 3.813E-13 7 14
8 IPR011704 ATPase dyneun-rel AAA InterPro 9.580E-16 4.766E-14 3.129E-13 3.813E-13 7 14
9 IPR004273 Dynein heavy dom InterPro 1.793E-15 6.487E-14 4.259E-13 7.136E-13 7 15
10 IPR026983 DHC fam InterPro 1.793E-15 6.487E-14 4.259E-13 7.136E-13 7 15
11 PF03028 Dynein heavy Pfam 1.793E-15 6.487E-14 4.259E-13 7.136E-13 7 15
12 IPR013594 Dynein heavy dom-1 InterPro 3.787E-15 1.159E-13 7.611E-13 1.507E-12 6 8
13 PF08385 DHC N1 Pfam 3.787E-15 1.159E-13 7.611E-13 1.507E-12 6 8
14 SM00382 AAA SMART 4.866E-8 1.291E-6 8.475E-6 1.937E-5 7 144
15 IPR003593 AAA+ ATPase InterPro 4.866E-8 1.291E-6 8.475E-6 1.937E-5 7 144
16 3.40.50.410 - Gene3D 2.955E-5 7.352E-4 4.826E-3 1.176E-2 4 74
17 PS00022 EGF 1 PROSITE 3.199E-5 7.489E-4 4.916E-3 1.273E-2 6 256
18 PS50234 VWFA PROSITE 4.430E-5 9.795E-4 6.431E-3 1.763E-2 4 82
19 SM00327 VWA SMART 4.870E-5 1.020E-3 6.697E-3 1.938E-2 4 84
20 IPR002035 VWF A InterPro 9.255E-5 1.824E-3 1.197E-2 3.684E-2 4 99
21 PS00010 ASX HYDROXYL PROSITE 9.624E-5 1.824E-3 1.197E-2 3.830E-2 4 100
22 IPR000152 EGF-type Asp/Asn hydroxyl site InterPro 1.207E-4 2.183E-3 1.433E-2 4.802E-2 4 106
23 SM00181 EGF SMART 2.463E-4 4.084E-3 2.681E-2
9.802E-2
 5 236
24 PS50026 EGF 3 PROSITE 2.463E-4 4.084E-3 2.681E-2
9.802E-2
 5 236
25 2.40.155.10 - Gene3D 3.060E-4 4.668E-3 3.064E-2
1.218E-1
 2 11
26 IPR023413 GFP-like InterPro 3.060E-4 4.668E-3 3.064E-2
1.218E-1
 2 11
27 IPR000742 EGF-like dom InterPro 3.212E-4 4.668E-3 3.064E-2
1.278E-1
 5 250
28 PF00092 VWA Pfam 3.284E-4 4.668E-3 3.064E-2
1.307E-1
 3 56
29 IPR013032 EGF-like CS InterPro 3.983E-4 5.466E-3 3.588E-2
1.585E-1
 5 262
30 PS01186 EGF 2 PROSITE 4.268E-4 5.662E-3 3.717E-2
1.699E-1
 5 266
31 PF07645 EGF CA Pfam 1.153E-3 1.480E-2
9.717E-2
4.589E-1
 3 86
32 2.60.120.200 - Gene3D 1.536E-3 1.517E-2
9.962E-2
6.113E-1
 3 95
33 IPR018097 EGF Ca-bd CS InterPro 1.631E-3 1.517E-2
9.962E-2
6.490E-1
 3 97
34 PS01187 EGF CA PROSITE 1.729E-3 1.517E-2
9.962E-2
6.881E-1
 3 99
35 IPR026823 cEGF InterPro 1.767E-3 1.517E-2
9.962E-2
7.034E-1
 2 26
36 PF12662 cEGF Pfam 1.767E-3 1.517E-2
9.962E-2
7.034E-1
 2 26
37 IPR013320 ConA-like dom InterPro 1.860E-3 1.517E-2
9.962E-2
7.401E-1
 4 219
38 PF12661 hEGF Pfam 2.049E-3 1.517E-2
9.962E-2
8.156E-1
 2 28
39 IPR030443 DNAH11 InterPro 2.402E-3 1.517E-2
9.962E-2
9.560E-1
 1 1
40 IPR030524 DLGAP1 InterPro 2.402E-3 1.517E-2
9.962E-2
9.560E-1
 1 1
41 IPR028850 MUC16 InterPro 2.402E-3 1.517E-2
9.962E-2
9.560E-1
 1 1
42 PF16901 DAO C Pfam 2.402E-3 1.517E-2
9.962E-2
9.560E-1
 1 1
43 IPR032991 Contactin-1 InterPro 2.402E-3 1.517E-2
9.962E-2
9.560E-1
 1 1
44 IPR013935 TRAPP II complex Trs120 InterPro 2.402E-3 1.517E-2
9.962E-2
9.560E-1
 1 1
45 IPR029824 Neurexin-1 InterPro 2.402E-3 1.517E-2
9.962E-2
9.560E-1
 1 1
46 PS00977 FAD G3PDH 1 PROSITE 2.402E-3 1.517E-2
9.962E-2
9.560E-1
 1 1
47 IPR000447 G3P DH FAD-dep InterPro 2.402E-3 1.517E-2
9.962E-2
9.560E-1
 1 1
48 IPR033768 Hydin ADK InterPro 2.402E-3 1.517E-2
9.962E-2
9.560E-1
 1 1
49 PF15877 TMEM232 Pfam 2.402E-3 1.517E-2
9.962E-2
9.560E-1
 1 1
50 IPR033305 Hydin InterPro 2.402E-3 1.517E-2
9.962E-2
9.560E-1
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 155 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M3008 Genes encoding structural ECM glycoproteins MSigDB C2 BIOCARTA (v5.1) 3.541E-7 5.488E-5 3.086E-4 5.488E-5 7 196
2 M5884 Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans MSigDB C2 BIOCARTA (v5.1) 3.439E-6 2.665E-4 1.499E-3 5.331E-4 7 275

8: Pubmed [Display Chart] 3068 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9256245 Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment. Pubmed 9.205E-15 2.824E-11 2.430E-10 2.824E-11 5 7
2 11175280 Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes. Pubmed 2.612E-9 4.006E-6 3.448E-5 8.013E-6 3 4
3 20301301 Primary Ciliary Dyskinesia Pubmed 1.913E-8 1.957E-5 1.684E-4 5.870E-5 4 32
4 19410201 Ciliary defects and genetics of primary ciliary dyskinesia. Pubmed 7.699E-7 4.724E-4 4.066E-3 2.362E-3 2 2
5 19410201:gr Ciliary defects and genetics of primary ciliary dyskinesia. GeneRIF 7.699E-7 4.724E-4 4.066E-3 2.362E-3 2 2
6 23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. Pubmed 9.548E-7 4.882E-4 4.202E-3 2.929E-3 5 199
7 9373155 Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. Pubmed 1.143E-6 5.008E-4 4.310E-3 3.506E-3 3 23
8 12388743 Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. Pubmed 2.308E-6 8.853E-4 7.619E-3 7.082E-3 2 3
9 15750039 Mislocalization of DNAH5 and DNAH9 in respiratory cells from patients with primary ciliary dyskinesia. Pubmed 4.614E-6 1.180E-3 1.015E-2 1.416E-2 2 4
10 18492703 Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia. Pubmed 4.614E-6 1.180E-3 1.015E-2 1.416E-2 2 4
11 18950741 DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm. Pubmed 4.614E-6 1.180E-3 1.015E-2 1.416E-2 2 4
12 18492703:gr Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia. GeneRIF 4.614E-6 1.180E-3 1.015E-2 1.416E-2 2 4
13 15845866 Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients. Pubmed 7.686E-6 1.684E-3 1.450E-2 2.358E-2 2 5
14 22499950 High prevalence of respiratory ciliary dysfunction in congenital heart disease patients with heterotaxy. Pubmed 7.686E-6 1.684E-3 1.450E-2 2.358E-2 2 5
15 8812413 Multiple mouse chromosomal loci for dynein-based motility. Pubmed 8.435E-6 1.725E-3 1.485E-2 2.588E-2 3 44
16 23849778 ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry. Pubmed 1.612E-5 1.887E-3 1.624E-2 4.946E-2 2 7
17 12853948 The DNA sequence of human chromosome 7. Pubmed 4.332E-5 1.887E-3 1.624E-2
1.329E-1
 5 438
18 15673434 A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins. Pubmed 5.968E-5 1.887E-3 1.624E-2
1.831E-1
 2 13
19 10737800 Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Pubmed 7.008E-5 1.887E-3 1.624E-2
2.150E-1
 5 485
20 19144635 Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2. Pubmed 8.025E-5 1.887E-3 1.624E-2
2.462E-1
 2 15
21 22036096 A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. Pubmed 9.166E-5 1.887E-3 1.624E-2
2.812E-1
 2 16
22 22832960 A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. Pubmed 1.038E-4 1.887E-3 1.624E-2
3.185E-1
 2 17
23 9205841 Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. Pubmed 1.117E-4 1.887E-3 1.624E-2
3.428E-1
 3 104
24 18834073 Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux. Pubmed 1.167E-4 1.887E-3 1.624E-2
3.581E-1
 2 18
25 18834073:gr Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux. GeneRIF 1.167E-4 1.887E-3 1.624E-2
3.581E-1
 2 18
26 19086053:gr Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. GeneRIF 1.480E-4 1.887E-3 1.624E-2
4.540E-1
 4 300
27 19086053 Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. Pubmed 1.480E-4 1.887E-3 1.624E-2
4.540E-1
 4 300
28 25189868 Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. Pubmed 3.754E-4 1.887E-3 1.624E-2
1.000E0
 2 32
29 20834067 Joint influence of small-effect genetic variants on human longevity. Pubmed 4.242E-4 1.887E-3 1.624E-2
1.000E0
 2 34
30 20201926:gr Human variation in alcohol response is influenced by variation in neuronal signaling genes. GeneRIF 4.820E-4 1.887E-3 1.624E-2
1.000E0
 3 171
31 20201926 Human variation in alcohol response is influenced by variation in neuronal signaling genes. Pubmed 4.820E-4 1.887E-3 1.624E-2
1.000E0
 3 171
32 22952603 Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). Pubmed 5.303E-4 1.887E-3 1.624E-2
1.000E0
 2 38
33 22589738 Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. Pubmed 6.849E-4 1.887E-3 1.624E-2
1.000E0
 3 193
34 18468998 Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. Pubmed 7.773E-4 1.887E-3 1.624E-2
1.000E0
 2 46
35 20404337:gr Microfibril structure masks fibrillin-2 in postnatal tissues. GeneRIF 8.871E-4 1.887E-3 1.624E-2
1.000E0
 1 1
36 18449964:gr Reelin is overexpressed in the liver and plasma of bile duct ligated rats and its levels and glycosylation are altered in plasma of humans with cirrhosis. GeneRIF 8.871E-4 1.887E-3 1.624E-2
1.000E0
 1 1
37 18797897:gr Predictive power of serum CA-125 and LDH in the outcome of first trimester pregnancies with human chorionic gonadotropin levels below discriminatory zone. GeneRIF 8.871E-4 1.887E-3 1.624E-2
1.000E0
 1 1
38 23110111 Overexpression of calcium-permeable glutamate receptors in glioblastoma derived brain tumor initiating cells. Pubmed 8.871E-4 1.887E-3 1.624E-2
1.000E0
 1 1
39 12132593:gr Carnosine and related dipeptides protect human ceruloplasmin against peroxyl radical-mediated modification. GeneRIF 8.871E-4 1.887E-3 1.624E-2
1.000E0
 1 1
40 22761302:gr Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice. GeneRIF 8.871E-4 1.887E-3 1.624E-2
1.000E0
 1 1
41 15304343:gr P-Rex2, a new guanine-nucleotide exchange factor for Rac. GeneRIF 8.871E-4 1.887E-3 1.624E-2
1.000E0
 1 1
42 24725366 Muscle histopathology in nebulin-related nemaline myopathy: ultrastrastructural findings correlated to disease severity and genotype. Pubmed 8.871E-4 1.887E-3 1.624E-2
1.000E0
 1 1
43 18641288 Disease course in patients with autosomal recessive retinitis pigmentosa due to the USH2A gene. Pubmed 8.871E-4 1.887E-3 1.624E-2
1.000E0
 1 1
44 22941678:gr Expression of multiple nebulin isoforms in human skeletal muscle and brain. GeneRIF 8.871E-4 1.887E-3 1.624E-2
1.000E0
 1 1
45 19892736:gr Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation. GeneRIF 8.871E-4 1.887E-3 1.624E-2
1.000E0
 1 1
46 26845862 [Association of Polymorphic Variants of Gene MUC19 with Asthma in Russians According to the Results of a Genome-Wide Study]. Pubmed 8.871E-4 1.887E-3 1.624E-2
1.000E0
 1 1
47 12575997 Translational control by the 3'-UTR: the ends specify the means. Pubmed 8.871E-4 1.887E-3 1.624E-2
1.000E0
 1 1
48 18273898:gr Spectrum of USH2A mutations in Scandinavian patients with Usher syndrome type II. GeneRIF 8.871E-4 1.887E-3 1.624E-2
1.000E0
 1 1
49 17033973 Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxia. Pubmed 8.871E-4 1.887E-3 1.624E-2
1.000E0
 1 1
50 21704414 DNA methylation changes in cells regrowing after fractioned ionizing radiation. Pubmed 8.871E-4 1.887E-3 1.624E-2
1.000E0
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 614 annotations before applied cutoff / 16534 genes in category

No results to display

10: Cytoband [Display Chart] 44 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1q25.3-q31.1 1q25.3-q31.1 1.269E-3 1.861E-2
8.136E-2
5.586E-2
 1 1
2 3q23-q25 3q23-q25 1.269E-3 1.861E-2
8.136E-2
5.586E-2
 1 1
3 5q23-q31 5q23-q31 2.537E-3 1.861E-2
8.136E-2
1.116E-1
 1 2
4 20q12-q13 20q12-q13 2.537E-3 1.861E-2
8.136E-2
1.116E-1
 1 2
5 12q11-q12 12q11-q12 2.537E-3 1.861E-2
8.136E-2
1.116E-1
 1 2
6 2q22 2q22 2.537E-3 1.861E-2
8.136E-2
1.116E-1
 1 2
7 7p14-p13 7p14-p13 5.068E-3 3.186E-2
1.393E-1
2.230E-1
 1 4
8 17q22-q23 17q22-q23 7.593E-3 4.045E-2
1.769E-1
3.341E-1
 1 6
9 7p21 7p21 8.853E-3 4.045E-2
1.769E-1
3.895E-1
 1 7
10 6q24 6q24 1.011E-2 4.045E-2
1.769E-1
4.449E-1
 1 8
11 21q11 21q11 1.011E-2 4.045E-2
1.769E-1
4.449E-1
 1 8
12 5q22.1 5q22.1 1.388E-2 4.697E-2
2.054E-1
6.106E-1
 1 11
13 8q13.2 8q13.2 1.388E-2 4.697E-2
2.054E-1
6.106E-1
 1 11
Show 8 more annotations

11: Transcription Factor Binding Site [Display Chart] 249 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 32 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 536 Dyneins, axonemal genenames.org 7.896E-16 2.527E-14 1.025E-13 2.527E-14 7 17
2 648 Mucins genenames.org 6.962E-4 1.114E-2 4.521E-2 2.228E-2 2 21
3 555 Fibronectin type III domain containing|Immunoglobulin like domain containing genenames.org 3.270E-3 3.488E-2
1.416E-1
1.046E-1
 3 160
4 1200 X-linked mental retardation|Glutamate ionotropic receptor AMPA type subunits genenames.org 7.455E-3 4.771E-2
1.936E-1
2.385E-1
 1 4
5 1244 Deafness associated genes|PDZ domain containing|USH2 complex genenames.org 7.455E-3 4.771E-2
1.936E-1
2.385E-1
 1 4

13: Coexpression [Display Chart] 2113 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M12671 Genes down-regulated in nsopharyngeal carcinoma relative to the normal tissue. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.793E-7 1.013E-3 8.339E-3 1.013E-3 8 347

14: Coexpression Atlas [Display Chart] 1379 annotations before applied cutoff / 20974 genes in category

No results to display

15: Computational [Display Chart] 164 annotations before applied cutoff / 9399 genes in category

No results to display

16: MicroRNA [Display Chart] 668 annotations before applied cutoff / 19844 genes in category

No results to display

17: Drug [Display Chart] 7727 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000002974 Biliton Stitch 2.149E-10 1.661E-6 1.582E-5 1.661E-6 6 41
2 CID000003674 IC261 Stitch 4.077E-8 1.575E-4 1.501E-3 3.150E-4 6 96
3 CID000004799 AC1L1IZE Stitch 2.606E-7 6.713E-4 6.397E-3 2.014E-3 6 131
4 CID000061671 vanadyl Stitch 2.692E-6 5.201E-3 4.957E-2 2.080E-2 7 307
5 4452 UP geldanamycin; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 3.099E-5 3.991E-2
3.803E-1
2.394E-1
 5 179
6 5489 UP Prenylamine lactate [69-43-2]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP 3.099E-5 3.991E-2
3.803E-1
2.394E-1
 5 179
7 6028 UP Promazine hydrochloride [53-60-1]; Up 200; 12.4uM; MCF7; HT HG-U133A Broad Institute CMAP 4.331E-5 4.409E-2
4.201E-1
3.346E-1
 5 192
8 450 UP 17-AAG; Up 200; 1uM; PC3; HG-U133A Broad Institute CMAP 4.663E-5 4.409E-2
4.201E-1
3.603E-1
 5 195
9 6001 UP Fenspiride hydrochloride [5053-08-7]; Up 200; 13.4uM; MCF7; HT HG-U133A Broad Institute CMAP 5.135E-5 4.409E-2
4.201E-1
3.968E-1
 5 199
Show 4 more annotations

18: Disease [Display Chart] 648 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0022521 Kartagener Syndrome DisGeNET Curated 1.184E-7 7.672E-5 5.410E-4 7.672E-5 6 93
2 umls:C0008780 Ciliary Motility Disorders DisGeNET Curated 3.058E-6 9.907E-4 6.986E-3 1.981E-3 4 40
3 244400 CILIARY DYSKINESIA, PRIMARY, 1; CILD1 OMIM 1.883E-5 4.068E-3 2.869E-2 1.220E-2 2 3
4 umls:C0270960 Congenital myopathy (disorder) DisGeNET BeFree 1.023E-4 1.657E-2
1.169E-1
6.629E-2
 3 36
5 umls:C0020255 Hydrocephalus DisGeNET Curated 4.934E-4 2.742E-2
1.933E-1
3.198E-1
 3 61
6 umls:C0454651 Specific language impairment DisGeNET BeFree 7.378E-4 2.742E-2
1.933E-1
4.781E-1
 2 16
7 umls:C0085400 Neurofibrillary degeneration (morphologic abnormality) DisGeNET Curated 8.105E-4 2.742E-2
1.933E-1
5.252E-1
 4 166
8 umls:C0022716 Menkes Kinky Hair Syndrome DisGeNET Curated 8.348E-4 2.742E-2
1.933E-1
5.409E-1
 2 17
9 umls:C1535926 Neurodevelopmental Disorders DisGeNET Curated 9.388E-4 2.742E-2
1.933E-1
6.083E-1
 3 76
10 umls:C0023012 Language Delay DisGeNET BeFree 1.046E-3 2.742E-2
1.933E-1
6.780E-1
 2 19
11 umls:C0266642 Situs ambiguus DisGeNET Curated 1.538E-3 2.742E-2
1.933E-1
9.967E-1
 2 23
12 umls:C0026650 Movement Disorders DisGeNET Curated 2.012E-3 2.742E-2
1.933E-1
1.000E0
 3 99
13 umls:C0155552 Hearing Loss, Mixed Conductive-Sensorineural DisGeNET BeFree 2.401E-3 2.742E-2
1.933E-1
1.000E0
 4 223
14 umls:C2675527 Myopathy, Congenital, Compton-North DisGeNET Curated 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
15 umls:C3280524 SCHIZOPHRENIA 17 DisGeNET Curated 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
16 umls:C1837618 CILIARY DYSKINESIA, PRIMARY, 3 DisGeNET Curated 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
17 121050 CONTRACTURAL ARACHNODACTYLY, CONGENITAL; CCA OMIM 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
18 umls:C3280479 PITT-HOPKINS-LIKE SYNDROME 2 DisGeNET Curated 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
19 umls:C0333068 Flexion contracture DisGeNET BeFree 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
20 608644 CILIARY DYSKINESIA, PRIMARY, 3; CILD3 OMIM 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
21 600994 DEAFNESS, AUTOSOMAL DOMINANT 5; DFNA5 OMIM 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
22 cv:C0220668 Congenital contractural arachnodactyly Clinical Variations 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
23 cv:C1832932 Deafness, autosomal dominant 5 Clinical Variations 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
24 20090301:Schrauwen Otosclerosis GWAS 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
25 cv:C2678473 Ciliary dyskinesia, primary, 7 Clinical Variations 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
26 umls:C0151731 Hepatic infarction DisGeNET BeFree 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
27 umls:C4015286 MACULAR DEGENERATION, EARLY-ONSET DisGeNET Curated 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
28 602081 SPEECH-LANGUAGE DISORDER 1; SPCH1 OMIM 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
29 611884 CILIARY DYSKINESIA, PRIMARY, 7; CILD7 OMIM 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
30 umls:C1850569 Nemaline Myopathy 2 DisGeNET Curated 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
31 umls:C0206145 Stunned Myocardium DisGeNET BeFree 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
32 umls:C2750791 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 13 DisGeNET Curated 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
33 umls:C3151138 RETINITIS PIGMENTOSA 39 (disorder) DisGeNET Curated 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
34 umls:C1832932 DEAFNESS, AUTOSOMAL DOMINANT 5 (disorder) DisGeNET Curated 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
35 umls:C0751050 Communication Disorders, Developmental DisGeNET BeFree 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
36 umls:C0349391 Apraxia, Verbal DisGeNET BeFree 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
37 umls:C3151520 Early severe fetal akinesia sequence DisGeNET Curated 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
38 612540 MYOPATHY, CONGENITAL, COMPTON-NORTH OMIM 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
39 cv:C1850569 Nemaline myopathy 2 Clinical Variations 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
40 cv:CN221671 Macular degeneration, early-onset Clinical Variations 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
41 cv:C2750791 Mental retardation, autosomal recessive 13 Clinical Variations 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
42 umls:C1858583 HEMOSIDEROSIS, SYSTEMIC, DUE TO ACERULOPLASMINEMIA DisGeNET Curated 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
43 cv:C3280479 Pitt-Hopkins-like syndrome 2 Clinical Variations 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
44 256030 NEMALINE MYOPATHY 2; NEM2 OMIM 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
45 cv:C1837615 Ciliary dyskinesia, primary, 5 Clinical Variations 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
46 cv:CN032592 Speech-language disorder 1 Clinical Variations 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
47 257320 LISSENCEPHALY 2; LIS2 OMIM 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
48 cv:C0796089 Lissencephaly 2 Clinical Variations 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
49 cv:C2675527 Myopathy, congenital, compton-north Clinical Variations 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
50 umls:C2678473 CILIARY DYSKINESIA, PRIMARY, 7 (disorder) DisGeNET Curated 2.539E-3 2.742E-2
1.933E-1
1.000E0
 1 1
Show 45 more annotations