Toppgene analysis for aggregated_1964_log, IC11, negative side

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1: GO: Molecular Function [Display Chart] 55 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003823 antigen binding 4.019E-5 2.211E-3 1.015E-2 2.211E-3 3 120
2 GO:0051087 chaperone binding 1.006E-3 2.143E-2
9.843E-2
5.531E-2
 2 82
3 GO:0044547 DNA topoisomerase binding 1.169E-3 2.143E-2
9.843E-2
6.428E-2
 1 2
4 GO:1990254 keratin filament binding 3.502E-3 4.166E-2
1.914E-1
1.926E-1
 1 6
5 GO:0046977 TAP binding 4.085E-3 4.166E-2
1.914E-1
2.247E-1
 1 7
6 GO:1990459 transferrin receptor binding 4.667E-3 4.166E-2
1.914E-1
2.567E-1
 1 8
7 GO:0070180 large ribosomal subunit rRNA binding 6.413E-3 4.166E-2
1.914E-1
3.527E-1
 1 11
8 GO:0003735 structural constituent of ribosome 6.737E-3 4.166E-2
1.914E-1
3.705E-1
 2 216
9 GO:0017160 Ral GTPase binding 7.575E-3 4.166E-2
1.914E-1
4.166E-1
 1 13
10 GO:0051787 misfolded protein binding 7.575E-3 4.166E-2
1.914E-1
4.166E-1
 1 13
11 GO:0023026 MHC class II protein complex binding 9.315E-3 4.535E-2
2.083E-1
5.123E-1
 1 16
12 GO:0019215 intermediate filament binding 9.895E-3 4.535E-2
2.083E-1
5.442E-1
 1 17
13 GO:0023023 MHC protein complex binding 1.105E-2 4.676E-2
2.148E-1
6.079E-1
 1 19
Show 8 more annotations

2: GO: Biological Process [Display Chart] 430 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0014009 glial cell proliferation 2.283E-4 3.382E-2
2.246E-1
9.816E-2
 2 39
2 GO:0043128 positive regulation of 1-phosphatidylinositol 4-kinase activity 5.856E-4 3.382E-2
2.246E-1
2.518E-1
 1 1
3 GO:0043126 regulation of 1-phosphatidylinositol 4-kinase activity 5.856E-4 3.382E-2
2.246E-1
2.518E-1
 1 1
4 GO:1902949 positive regulation of tau-protein kinase activity 5.856E-4 3.382E-2
2.246E-1
2.518E-1
 1 1
5 GO:1902847 regulation of neuronal signal transduction 5.856E-4 3.382E-2
2.246E-1
2.518E-1
 1 1
6 GO:0061517 macrophage proliferation 1.171E-3 3.382E-2
2.246E-1
5.035E-1
 1 2
7 GO:0061518 microglial cell proliferation 1.171E-3 3.382E-2
2.246E-1
5.035E-1
 1 2
8 GO:1904352 positive regulation of protein catabolic process in the vacuole 1.171E-3 3.382E-2
2.246E-1
5.035E-1
 1 2
9 GO:1902998 positive regulation of neurofibrillary tangle assembly 1.171E-3 3.382E-2
2.246E-1
5.035E-1
 1 2
10 GO:0090150 establishment of protein localization to membrane 1.183E-3 3.382E-2
2.246E-1
5.086E-1
 3 378
11 GO:0021782 glial cell development 1.187E-3 3.382E-2
2.246E-1
5.105E-1
 2 89
12 GO:0006614 SRP-dependent cotranslational protein targeting to membrane 1.323E-3 3.382E-2
2.246E-1
5.690E-1
 2 94
13 GO:0006613 cotranslational protein targeting to membrane 1.525E-3 3.382E-2
2.246E-1
6.559E-1
 2 101
14 GO:0045047 protein targeting to ER 1.586E-3 3.382E-2
2.246E-1
6.818E-1
 2 103
15 GO:0072599 establishment of protein localization to endoplasmic reticulum 1.710E-3 3.382E-2
2.246E-1
7.351E-1
 2 107
16 GO:1904350 regulation of protein catabolic process in the vacuole 1.756E-3 3.382E-2
2.246E-1
7.550E-1
 1 3
17 GO:1902996 regulation of neurofibrillary tangle assembly 1.756E-3 3.382E-2
2.246E-1
7.550E-1
 1 3
18 GO:1902988 neurofibrillary tangle assembly 1.756E-3 3.382E-2
2.246E-1
7.550E-1
 1 3
19 GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent 1.756E-3 3.382E-2
2.246E-1
7.550E-1
 1 3
20 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 1.871E-3 3.382E-2
2.246E-1
8.045E-1
 2 112
21 GO:0019058 viral life cycle 1.915E-3 3.382E-2
2.246E-1
8.236E-1
 3 447
22 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 2.179E-3 3.382E-2
2.246E-1
9.369E-1
 2 121
23 GO:0042552 myelination 2.214E-3 3.382E-2
2.246E-1
9.522E-1
 2 122
24 GO:0008366 axon ensheathment 2.286E-3 3.382E-2
2.246E-1
9.832E-1
 2 124
25 GO:0007272 ensheathment of neurons 2.286E-3 3.382E-2
2.246E-1
9.832E-1
 2 124
26 GO:1902947 regulation of tau-protein kinase activity 2.340E-3 3.382E-2
2.246E-1
1.000E0
 1 4
27 GO:1900147 regulation of Schwann cell migration 2.340E-3 3.382E-2
2.246E-1
1.000E0
 1 4
28 GO:0036135 Schwann cell migration 2.340E-3 3.382E-2
2.246E-1
1.000E0
 1 4
29 GO:0032286 central nervous system myelin maintenance 2.340E-3 3.382E-2
2.246E-1
1.000E0
 1 4
30 GO:0070972 protein localization to endoplasmic reticulum 2.360E-3 3.382E-2
2.246E-1
1.000E0
 2 126
31 GO:0046813 receptor-mediated virion attachment to host cell 2.925E-3 3.837E-2
2.548E-1
1.000E0
 1 5
32 GO:0007039 protein catabolic process in the vacuole 2.925E-3 3.837E-2
2.548E-1
1.000E0
 1 5
33 GO:0010977 negative regulation of neuron projection development 3.410E-3 3.837E-2
2.548E-1
1.000E0
 2 152
34 GO:1900221 regulation of beta-amyloid clearance 3.509E-3 3.837E-2
2.548E-1
1.000E0
 1 6
35 GO:0090385 phagosome-lysosome fusion 3.509E-3 3.837E-2
2.548E-1
1.000E0
 1 6
36 GO:1902993 positive regulation of amyloid precursor protein catabolic process 3.509E-3 3.837E-2
2.548E-1
1.000E0
 1 6
37 GO:1902430 negative regulation of beta-amyloid formation 3.509E-3 3.837E-2
2.548E-1
1.000E0
 1 6
38 GO:1902004 positive regulation of beta-amyloid formation 3.509E-3 3.837E-2
2.548E-1
1.000E0
 1 6
39 GO:0023041 neuronal signal transduction 4.092E-3 3.837E-2
2.548E-1
1.000E0
 1 7
40 GO:0097242 beta-amyloid clearance 4.092E-3 3.837E-2
2.548E-1
1.000E0
 1 7
41 GO:0032463 negative regulation of protein homooligomerization 4.092E-3 3.837E-2
2.548E-1
1.000E0
 1 7
42 GO:0090261 positive regulation of inclusion body assembly 4.092E-3 3.837E-2
2.548E-1
1.000E0
 1 7
43 GO:0042270 protection from natural killer cell mediated cytotoxicity 4.092E-3 3.837E-2
2.548E-1
1.000E0
 1 7
44 GO:0019083 viral transcription 4.541E-3 3.837E-2
2.548E-1
1.000E0
 2 176
45 GO:1902992 negative regulation of amyloid precursor protein catabolic process 4.676E-3 3.837E-2
2.548E-1
1.000E0
 1 8
46 GO:0031345 negative regulation of cell projection organization 4.693E-3 3.837E-2
2.548E-1
1.000E0
 2 179
47 GO:0019080 viral gene expression 5.110E-3 3.837E-2
2.548E-1
1.000E0
 2 187
48 GO:0031398 positive regulation of protein ubiquitination 5.217E-3 3.837E-2
2.548E-1
1.000E0
 2 189
49 GO:0002870 T cell anergy 5.259E-3 3.837E-2
2.548E-1
1.000E0
 1 9
50 GO:0002249 lymphocyte anergy 5.259E-3 3.837E-2
2.548E-1
1.000E0
 1 9
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 95 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005925 focal adhesion 1.984E-4 6.918E-3 3.553E-2 1.885E-2 4 393
2 GO:0005924 cell-substrate adherens junction 2.083E-4 6.918E-3 3.553E-2 1.979E-2 4 398
3 GO:0030055 cell-substrate junction 2.185E-4 6.918E-3 3.553E-2 2.075E-2 4 403
4 GO:0005912 adherens junction 4.388E-4 1.042E-2
5.353E-2
 4.169E-2 4 484
5 GO:0030670 phagocytic vesicle membrane 1.018E-3 1.934E-2
9.935E-2
9.672E-2
 2 61
6 GO:0045335 phagocytic vesicle 2.151E-3 3.406E-2
1.749E-1
2.044E-1
 2 89
7 GO:0022626 cytosolic ribosome 3.805E-3 4.123E-2
2.118E-1
3.615E-1
 2 119
8 GO:0045098 type III intermediate filament 3.906E-3 4.123E-2
2.118E-1
3.711E-1
 1 5
9 GO:0097418 neurofibrillary tangle 3.906E-3 4.123E-2
2.118E-1
3.711E-1
 1 5
Show 4 more annotations

4: Human Phenotype [Display Chart] 63 annotations before applied cutoff / 4410 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0007657 Diffuse nuclear cataract 1.361E-3 3.427E-2
1.620E-1
8.571E-2
 1 1
2 HP:0007131 Acute demyelinating polyneuropathy 1.361E-3 3.427E-2
1.620E-1
8.571E-2
 1 1
3 HP:0100686 Enthesitis 2.720E-3 3.427E-2
1.620E-1
1.713E-1
 1 2
4 HP:0012122 Anterior uveitis 2.720E-3 3.427E-2
1.620E-1
1.713E-1
 1 2
5 HP:0003449 Cold-induced muscle cramps 2.720E-3 3.427E-2
1.620E-1
1.713E-1
 1 2
6 HP:0007351 Upper limb postural tremor 4.077E-3 3.686E-2
1.743E-1
2.569E-1
 1 3
7 HP:0011463 Childhood onset 4.096E-3 3.686E-2
1.743E-1
2.580E-1
 2 75
8 HP:0004336 Myelin outfoldings 5.433E-3 3.803E-2
1.798E-1
3.423E-1
 1 4
9 HP:0030270 Elevated red cell adenosine deaminase activity 5.433E-3 3.803E-2
1.798E-1
3.423E-1
 1 4
10 HP:0001897 Normocytic anemia 6.787E-3 4.276E-2
2.022E-1
4.276E-1
 1 5
11 HP:0003382 Hypertrophic nerve changes 8.140E-3 4.662E-2
2.204E-1
5.128E-1
 1 6
12 HP:0001884 Talipes calcaneovalgus 9.491E-3 4.879E-2
2.307E-1
5.980E-1
 1 7
13 HP:0001178 Ulnar claw 1.084E-2 4.879E-2
2.307E-1
6.830E-1
 1 8
14 HP:0007722 Retinal pigment epithelial atrophy 1.084E-2 4.879E-2
2.307E-1
6.830E-1
 1 8
Show 9 more annotations

5: Mouse Phenotype [Display Chart] 280 annotations before applied cutoff / 9299 genes in category

No results to display

6: Domain [Display Chart] 72 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR028139 Humanin InterPro 4.086E-11 1.471E-9 7.150E-9 2.942E-9 4 10
2 PF15040 Humanin Pfam 4.086E-11 1.471E-9 7.150E-9 2.942E-9 4 10
3 PF01780 Ribosomal L37ae Pfam 7.473E-4 4.677E-3 2.273E-2
5.380E-2
 1 1
4 IPR002674 Ribosomal L37ae InterPro 7.473E-4 4.677E-3 2.273E-2
5.380E-2
 1 1
5 PS00493 CLUSTERIN 2 PROSITE 7.473E-4 4.677E-3 2.273E-2
5.380E-2
 1 1
6 IPR003936 PMP22 InterPro 7.473E-4 4.677E-3 2.273E-2
5.380E-2
 1 1
7 PS00492 CLUSTERIN 1 PROSITE 7.473E-4 4.677E-3 2.273E-2
5.380E-2
 1 1
8 IPR016016 Clusterin InterPro 7.473E-4 4.677E-3 2.273E-2
5.380E-2
 1 1
9 IPR018271 Ribosomal S14 CS InterPro 7.473E-4 4.677E-3 2.273E-2
5.380E-2
 1 1
10 SM01154 DUF1704 SMART 1.494E-3 4.677E-3 2.273E-2
1.076E-1
 1 2
11 PF00253 Ribosomal S14 Pfam 1.494E-3 4.677E-3 2.273E-2
1.076E-1
 1 2
12 IPR012548 DUF1704 InterPro 1.494E-3 4.677E-3 2.273E-2
1.076E-1
 1 2
13 PF01093 Clusterin Pfam 1.494E-3 4.677E-3 2.273E-2
1.076E-1
 1 2
14 SM00030 CLb SMART 1.494E-3 4.677E-3 2.273E-2
1.076E-1
 1 2
15 IPR016015 Clusterin C InterPro 1.494E-3 4.677E-3 2.273E-2
1.076E-1
 1 2
16 2.20.25.30 - Gene3D 1.494E-3 4.677E-3 2.273E-2
1.076E-1
 1 2
17 IPR000753 Clusterin-like InterPro 1.494E-3 4.677E-3 2.273E-2
1.076E-1
 1 2
18 SM00035 CLa SMART 1.494E-3 4.677E-3 2.273E-2
1.076E-1
 1 2
19 IPR001209 Ribosomal S14 InterPro 1.494E-3 4.677E-3 2.273E-2
1.076E-1
 1 2
20 IPR011331 Ribosomal L37ae/L37e InterPro 1.494E-3 4.677E-3 2.273E-2
1.076E-1
 1 2
21 IPR016014 Clusterin N InterPro 1.494E-3 4.677E-3 2.273E-2
1.076E-1
 1 2
22 PF08014 DUF1704 Pfam 1.494E-3 4.677E-3 2.273E-2
1.076E-1
 1 2
23 PS00527 RIBOSOMAL S14 PROSITE 1.494E-3 4.677E-3 2.273E-2
1.076E-1
 1 2
24 IPR028977 CD81 LEL InterPro 3.731E-3 1.075E-2
5.223E-2
2.686E-1
 1 5
25 1.10.1450.10 - Gene3D 3.731E-3 1.075E-2
5.223E-2
2.686E-1
 1 5
26 IPR010579 MHC I a C InterPro 4.476E-3 1.194E-2
5.802E-2
3.223E-1
 1 6
27 PF06623 MHC I C Pfam 4.476E-3 1.194E-2
5.802E-2
3.223E-1
 1 6
28 PF04732 Filament head Pfam 5.220E-3 1.296E-2
6.300E-2
3.758E-1
 1 7
29 IPR006821 Intermed filament DNA-bd InterPro 5.220E-3 1.296E-2
6.300E-2
3.758E-1
 1 7
30 PS01221 PMP22 1 PROSITE 6.707E-3 1.463E-2
7.113E-2
4.829E-1
 1 9
31 PS01222 PMP22 2 PROSITE 6.707E-3 1.463E-2
7.113E-2
4.829E-1
 1 9
32 IPR011332 Ribosomal zn-bd InterPro 6.707E-3 1.463E-2
7.113E-2
4.829E-1
 1 9
33 IPR004032 PMP22 EMP MP20 InterPro 6.707E-3 1.463E-2
7.113E-2
4.829E-1
 1 9
34 IPR009050 Globin-like InterPro 1.189E-2 2.519E-2
1.224E-1
8.564E-1
 1 16
35 IPR018503 Tetraspanin CS InterPro 1.558E-2 3.033E-2
1.474E-1
1.000E0
 1 21
36 PF00129 MHC I Pfam 1.558E-2 3.033E-2
1.474E-1
1.000E0
 1 21
37 IPR001039 MHC I a a1/a2 InterPro 1.558E-2 3.033E-2
1.474E-1
1.000E0
 1 21
38 IPR011161 MHC I-like Ag-recog InterPro 1.779E-2 3.285E-2
1.597E-1
1.000E0
 1 24
39 3.30.500.10 - Gene3D 1.779E-2 3.285E-2
1.597E-1
1.000E0
 1 24
40 PS00421 TM4 1 PROSITE 1.926E-2 3.467E-2
1.685E-1
1.000E0
 1 26
41 IPR000301 Tetraspanin InterPro 2.366E-2 3.991E-2
1.940E-1
1.000E0
 1 32
42 IPR008952 Tetraspanin EC2 InterPro 2.366E-2 3.991E-2
1.940E-1
1.000E0
 1 32
43 IPR018499 Tetraspanin/Peripherin InterPro 2.439E-2 3.991E-2
1.940E-1
1.000E0
 1 33
44 PF00335 Tetraspannin Pfam 2.439E-2 3.991E-2
1.940E-1
1.000E0
 1 33
45 IPR011162 MHC I/II-like Ag-recog InterPro 2.803E-2 4.485E-2
2.180E-1
1.000E0
 1 38
46 PF00822 PMP22 Claudin Pfam 2.949E-2 4.616E-2
2.244E-1
1.000E0
 1 40
47 IPR002957 Keratin I InterPro 3.239E-2 4.962E-2
2.412E-1
1.000E0
 1 44
48 IPR004031 PMP22/EMP/MP20/Claudin InterPro 3.312E-2 4.968E-2
2.415E-1
1.000E0
 1 45
Show 43 more annotations

7: Pathway [Display Chart] 76 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 106413 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell BioSystems: REACTOME 1.530E-3 2.126E-2
1.045E-1
1.163E-1
 2 95
2 198853 Cytoplasmic Ribosomal Proteins BioSystems: WikiPathways 2.468E-3 2.126E-2
1.045E-1
1.875E-1
 2 121
3 83036 Ribosome BioSystems: KEGG 3.061E-3 2.126E-2
1.045E-1
2.327E-1
 2 135
4 105977 Peptide chain elongation BioSystems: REACTOME 3.288E-3 2.126E-2
1.045E-1
2.499E-1
 2 140
5 106077 Viral mRNA Translation BioSystems: REACTOME 3.288E-3 2.126E-2
1.045E-1
2.499E-1
 2 140
6 105978 Eukaryotic Translation Termination BioSystems: REACTOME 3.288E-3 2.126E-2
1.045E-1
2.499E-1
 2 140
7 366242 Nonsense Mediated Decay Independent of the Exon Junction Complex BioSystems: REACTOME 3.523E-3 2.126E-2
1.045E-1
2.677E-1
 2 145
8 105976 Eukaryotic Translation Elongation BioSystems: REACTOME 3.618E-3 2.126E-2
1.045E-1
2.750E-1
 2 147
9 105968 Formation of a pool of free 40S subunits BioSystems: REACTOME 3.814E-3 2.126E-2
1.045E-1
2.899E-1
 2 151
10 106074 Influenza Viral RNA Transcription and Replication BioSystems: REACTOME 4.065E-3 2.126E-2
1.045E-1
3.090E-1
 2 156
11 160955 L13a-mediated translational silencing of Ceruloplasmin expression BioSystems: REACTOME 4.324E-3 2.126E-2
1.045E-1
3.287E-1
 2 161
12 105973 GTP hydrolysis and joining of the 60S ribosomal subunit BioSystems: REACTOME 4.377E-3 2.126E-2
1.045E-1
3.327E-1
 2 162
13 366241 Nonsense Mediated Decay Enhanced by the Exon Junction Complex BioSystems: REACTOME 4.430E-3 2.126E-2
1.045E-1
3.367E-1
 2 163
14 366240 Nonsense-Mediated Decay BioSystems: REACTOME 4.430E-3 2.126E-2
1.045E-1
3.367E-1
 2 163
15 530746 SRP-dependent cotranslational protein targeting to membrane BioSystems: REACTOME 4.537E-3 2.126E-2
1.045E-1
3.448E-1
 2 165
16 105966 Eukaryotic Translation Initiation BioSystems: REACTOME 4.755E-3 2.126E-2
1.045E-1
3.614E-1
 2 169
17 105967 Cap-dependent Translation Initiation BioSystems: REACTOME 4.755E-3 2.126E-2
1.045E-1
3.614E-1
 2 169
18 106068 Influenza Life Cycle BioSystems: REACTOME 6.036E-3 2.438E-2
1.198E-1
4.588E-1
 2 191
19 106067 Influenza Infection BioSystems: REACTOME 6.348E-3 2.438E-2
1.198E-1
4.824E-1
 2 196
20 585562 Epstein-Barr virus infection BioSystems: KEGG 6.796E-3 2.438E-2
1.198E-1
5.165E-1
 2 203
21 477125 Endosomal/Vacuolar pathway BioSystems: REACTOME 7.035E-3 2.438E-2
1.198E-1
5.346E-1
 1 11
22 105965 Translation BioSystems: REACTOME 7.058E-3 2.438E-2
1.198E-1
5.364E-1
 2 207
23 105679 Caspase-mediated cleavage of cytoskeletal proteins BioSystems: REACTOME 7.672E-3 2.535E-2
1.246E-1
5.831E-1
 1 12
24 366163 Antigen Presentation: Folding, assembly and peptide loading of class I MHC BioSystems: REACTOME 1.529E-2 4.843E-2
2.380E-1
1.000E0
 1 24
Show 19 more annotations

8: Pubmed [Display Chart] 5106 annotations before applied cutoff / 51853 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20542501 Immunolocalization of humanin in human sperm and testis. Pubmed 5.706E-13 1.214E-9 1.106E-8 2.913E-9 4 9
2 19623253 Humanin: a novel central regulator of peripheral insulin action. Pubmed 5.706E-13 1.214E-9 1.106E-8 2.913E-9 4 9
3 25630734 The human mitochondrial genome may code for more than 13 proteins. Pubmed 9.508E-13 1.214E-9 1.106E-8 4.855E-9 4 10
4 23402768 Humanin: a harbinger of mitochondrial-derived peptides? Pubmed 9.508E-13 1.214E-9 1.106E-8 4.855E-9 4 10
5 12732850 Humanin peptide suppresses apoptosis by interfering with Bax activation. Pubmed 1.494E-12 1.525E-9 1.391E-8 7.627E-9 4 11
6 19477263 Evidence for potential functionality of nuclearly-encoded humanin isoforms. Pubmed 3.235E-12 2.360E-9 2.151E-8 1.652E-8 4 13
7 12009529 Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. Pubmed 3.235E-12 2.360E-9 2.151E-8 1.652E-8 4 13
8 11371646 A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Pubmed 4.529E-12 2.891E-9 2.635E-8 2.312E-8 4 14
9 21423176 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for Ã?-Pix in negative regulation of focal adhesion maturation. Pubmed 1.179E-6 6.690E-4 6.098E-3 6.021E-3 4 286
10 25275127 HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins. Pubmed 6.054E-5 7.258E-4 6.616E-3
3.091E-1
 2 40
11 16289162 The identification of myocilin-associated proteins in the human trabecular meshwork. Pubmed 6.680E-5 7.258E-4 6.616E-3
3.411E-1
 2 42
12 16625196 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Pubmed 2.028E-4 7.258E-4 6.616E-3
1.000E0
 2 73
13 19199708 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Pubmed 2.141E-4 7.258E-4 6.616E-3
1.000E0
 3 414
14 8722009 Structure and evolution of mammalian ribosomal proteins. Pubmed 2.436E-4 7.258E-4 6.616E-3
1.000E0
 2 80
15 15189156 The molecular mechanics of eukaryotic translation. Pubmed 2.881E-4 7.258E-4 6.616E-3
1.000E0
 2 87
16 12370371 Uniquely conformed peptide-containing beta 2-microglobulin-free heavy chains of HLA-B2705 on the cell surface. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
17 20873220:gr [Analysis of clusterin gene (CLU/APOJ) polymorphism in Alzheimer's disease patients and in normal cohorts from Russian populations]. GeneRIF 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
18 17911426:gr B27 disease is a new autoimmune disease that affects millions of people. GeneRIF 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
19 23916069 HLA-B27 and antigen presentation: at the crossroads between immune defense and autoimmunity. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
20 16493052 Lack of tyrosine 320 impairs spontaneous endocytosis and enhances release of HLA-B27 molecules. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
21 17274979:gr Regulation of clusterin expression in mammary epithelial cells. GeneRIF 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
22 11556975 Sequence, genetics and serology of a new HLA-B allele: B*4903. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
23 18945256 The prevalence, clinical features and association of HLA-B27 in sacroiliitis associated with established Crohn's disease. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
24 22701550 Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
25 22320938 HLA-B*07 is a high risk allele for familial cervical cancer. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
26 25339761 A view of the E2-CD81 interface at the binding site of a neutralizing antibody against hepatitis C virus. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
27 23956249 Evolution of radiographic damage in ankylosing spondylitis: a 12 year prospective follow-up of the OASIS study. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
28 18424159 Low frequency of HLA-B27 in ankylosing spondylitis patients from Turkey. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
29 24600035 Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
30 15649646 Differential effects of clusterin/apolipoprotein J on cellular growth and survival. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
31 19013628 Cellular vimentin content regulates the protein level of hepatitis C virus core protein and the hepatitis C virus production in cultured cells. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
32 21705835 HLA-B27 association with uveitis in an Asian Indian population. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
33 22461701:gr HLA-B7-restricted EBV-specific CD8+ T cells are dysregulated in multiple sclerosis. GeneRIF 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
34 15891642 Sensorineural hearing impairment in patients with Pmp22 duplication, deletion, and frameshift mutations. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
35 21630085 Regulation of chemosensitivity and migration by clusterin in non-small cell lung cancer cells. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
36 21644226:gr [Identification of a novel allele HLA-B*15:129 by polymerase chain reaction with allele group-specific primers]. GeneRIF 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
37 26248534 Prevalence of HLA-B27 in Moroccan healthy subjects and patients with ankylosing spondylitis and mapping construction of several factors influencing AS diagnosis by using multiple correspondence analysis. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
38 16641285:gr Different domains of CD81 mediate distinct stages of hepatitis C virus pseudoparticle entry. GeneRIF 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
39 18176708:gr Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors. GeneRIF 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
40 9190204 Topogenesis of a nucleolar protein: determination of molecular segments directing nucleolar association. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
41 18852831 Of race, ethnicity, and rash: the genetics of antiepileptic drug-induced skin reactions. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
42 16490286 Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
43 7675244 Dejerine-Sottas disease with de novo dominant point mutation of the PMP22 gene. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
44 21337347 Report of a novel mutation in the PMP22 gene causing an axonal neuropathy. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
45 17580542 [Hla-B27 gene: polymorphism, evolution, distribution, and association with spondyloartopathies]. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
46 17050693 Monitoring intermediate filament assembly by small-angle x-ray scattering reveals the molecular architecture of assembly intermediates. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
47 14581692:gr Hypoglossal neuropathy in hereditary neuropathy with liability to pressure palsy. GeneRIF 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
48 7626703 Expression of apolipoprotein J in the uterus is associated with tissue remodeling. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
49 7725306 HLA class I variation in Australian aborigines: characterization of allele B*1521. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
50 26610302 The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis. Pubmed 2.893E-4 7.258E-4 6.616E-3
1.000E0
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 762 annotations before applied cutoff / 16534 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:SERBP1 SERBP1 interactions 1.923E-9 1.465E-6 1.057E-5 1.465E-6 5 90
2 int:RPS28 RPS28 interactions 4.425E-5 8.460E-3
6.103E-2
 3.372E-2 3 109
3 int:RPS15 RPS15 interactions 6.659E-5 8.460E-3
6.103E-2
5.074E-2
 3 125
4 int:RPL27 RPL27 interactions 8.190E-5 8.460E-3
6.103E-2
6.241E-2
 3 134
5 int:RPL12 RPL12 interactions 9.935E-5 8.460E-3
6.103E-2
7.570E-2
 3 143
6 int:RPS23 RPS23 interactions 1.035E-4 8.460E-3
6.103E-2
7.889E-2
 3 145
7 int:RPS25 RPS25 interactions 1.168E-4 8.460E-3
6.103E-2
8.897E-2
 3 151
8 int:RPS18 RPS18 interactions 1.262E-4 8.460E-3
6.103E-2
9.614E-2
 3 155
9 int:RPS9 RPS9 interactions 1.386E-4 8.460E-3
6.103E-2
1.056E-1
 3 160
10 int:TUFM TUFM interactions 1.386E-4 8.460E-3
6.103E-2
1.056E-1
 3 160
11 int:HABP4 HABP4 interactions 1.618E-4 8.460E-3
6.103E-2
1.233E-1
 2 29
12 int:RPS19 RPS19 interactions 1.630E-4 8.460E-3
6.103E-2
1.242E-1
 3 169
13 int:RPS14 RPS14 interactions 1.717E-4 8.460E-3
6.103E-2
1.308E-1
 3 172
14 int:RPS13 RPS13 interactions 1.717E-4 8.460E-3
6.103E-2
1.308E-1
 3 172
15 int:RPS7 RPS7 interactions 1.746E-4 8.460E-3
6.103E-2
1.331E-1
 3 173
16 int:RPS16 RPS16 interactions 1.776E-4 8.460E-3
6.103E-2
1.354E-1
 3 174
17 int:NKX3-1 NKX3-1 interactions 2.504E-4 1.122E-2
8.097E-2
1.908E-1
 2 36
18 int:RPS6 RPS6 interactions 2.678E-4 1.134E-2
8.179E-2
2.041E-1
 3 200
19 int:RPS4X RPS4X interactions 2.880E-4 1.155E-2
8.332E-2
2.195E-1
 3 205
20 int:RPS3A RPS3A interactions 3.267E-4 1.245E-2
8.980E-2
2.490E-1
 3 214
21 int:MYOC MYOC interactions 4.099E-4 1.407E-2
1.015E-1
3.123E-1
 2 46
22 int:TRIM28 TRIM28 interactions 4.246E-4 1.407E-2
1.015E-1
3.235E-1
 3 234
23 int:RPS3 RPS3 interactions 4.246E-4 1.407E-2
1.015E-1
3.235E-1
 3 234
24 int:TTR TTR interactions 4.464E-4 1.417E-2
1.022E-1
3.402E-1
 2 48
25 int:RPS8 RPS8 interactions 6.242E-4 1.903E-2
1.372E-1
4.756E-1
 3 267
26 int:RPS2 RPS2 interactions 6.659E-4 1.952E-2
1.408E-1
5.074E-1
 3 273
27 int:FAU FAU interactions 6.974E-4 1.962E-2
1.415E-1
5.314E-1
 2 60
28 int:TUBB6 TUBB6 interactions 7.208E-4 1.962E-2
1.415E-1
5.492E-1
 2 61
29 int:PKN1 PKN1 interactions 7.687E-4 2.020E-2
1.457E-1
5.857E-1
 2 63
30 int:EIF4A2 EIF4A2 interactions 8.181E-4 2.078E-2
1.499E-1
6.234E-1
 2 65
31 int:NEAT1 NEAT1 interactions 1.330E-3 3.270E-2
2.359E-1
1.000E0
 1 2
32 int:EXOSC4 EXOSC4 interactions 1.493E-3 3.454E-2
2.492E-1
1.000E0
 2 88
33 int:SYVN1 SYVN1 interactions 1.561E-3 3.454E-2
2.492E-1
1.000E0
 2 90
34 int:EIF3I EIF3I interactions 1.595E-3 3.454E-2
2.492E-1
1.000E0
 2 91
35 int:RPS17 RPS17 interactions 1.630E-3 3.454E-2
2.492E-1
1.000E0
 2 92
36 int:RPL26 RPL26 interactions 1.737E-3 3.454E-2
2.492E-1
1.000E0
 2 95
37 int:EEF1A1 EEF1A1 interactions 1.880E-3 3.454E-2
2.492E-1
1.000E0
 3 391
38 int:POLR1C POLR1C interactions 1.885E-3 3.454E-2
2.492E-1
1.000E0
 2 99
39 int:CD4 CD4 interactions 1.922E-3 3.454E-2
2.492E-1
1.000E0
 2 100
40 int:DPPA4 DPPA4 interactions 1.960E-3 3.454E-2
2.492E-1
1.000E0
 2 101
41 int:UPP2 UPP2 interactions 1.995E-3 3.454E-2
2.492E-1
1.000E0
 1 3
42 int:EPPIN EPPIN interactions 1.995E-3 3.454E-2
2.492E-1
1.000E0
 1 3
43 int:MMP25 MMP25 interactions 1.995E-3 3.454E-2
2.492E-1
1.000E0
 1 3
44 int:ARMCX2 ARMCX2 interactions 1.995E-3 3.454E-2
2.492E-1
1.000E0
 1 3
45 int:FUBP1 FUBP1 interactions 2.077E-3 3.517E-2
2.537E-1
1.000E0
 2 104
46 int:RPS21 RPS21 interactions 2.361E-3 3.618E-2
2.610E-1
1.000E0
 2 111
47 int:NUDT21 NUDT21 interactions 2.489E-3 3.618E-2
2.610E-1
1.000E0
 2 114
48 int:EEF1D EEF1D interactions 2.489E-3 3.618E-2
2.610E-1
1.000E0
 2 114
49 int:RPS12 RPS12 interactions 2.532E-3 3.618E-2
2.610E-1
1.000E0
 2 115
50 int:RPL35 RPL35 interactions 2.619E-3 3.618E-2
2.610E-1
1.000E0
 2 117
Show 45 more annotations

10: Cytoband [Display Chart] 14 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 8p21-p12 8p21-p12 4.039E-4 5.655E-3 1.839E-2 5.655E-3 1 1
2 20q13.31 20q13.31 6.846E-3 3.933E-2
1.279E-1
9.584E-2
 1 17
3 11p15.3 11p15.3 9.252E-3 3.933E-2
1.279E-1
1.295E-1
 1 23
4 9p21 9p21 1.205E-2 3.933E-2
1.279E-1
1.687E-1
 1 30
5 Xp11.21 Xp11.21 1.405E-2 3.933E-2
1.279E-1
1.967E-1
 1 35
6 10p13 10p13 1.842E-2 4.081E-2
1.327E-1
2.579E-1
 1 46
7 17p12 17p12 2.041E-2 4.081E-2
1.327E-1
2.857E-1
 1 51
8 11q13.1 11q13.1 2.673E-2 4.678E-2
1.521E-1
3.742E-1
 1 67
Show 3 more annotations

11: Transcription Factor Binding Site [Display Chart] 73 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 10 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 610 Intermediate filaments Type III genenames.org 2.197E-3 2.197E-2
6.434E-2
 2.197E-2 1 5
2 768 CD molecules|Tetraspanins genenames.org 1.442E-2 3.702E-2
1.084E-1
1.442E-1
 1 33
3 728 S ribosomal proteins genenames.org 1.486E-2 3.702E-2
1.084E-1
1.486E-1
 1 34
4 591 C1-set domain containing genenames.org 1.832E-2 3.702E-2
1.084E-1
1.832E-1
 1 42
5 588 Histocompatibility complex|C1-set domain containing genenames.org 1.919E-2 3.702E-2
1.084E-1
1.919E-1
 1 44
6 729 L ribosomal proteins genenames.org 2.221E-2 3.702E-2
1.084E-1
2.221E-1
 1 51
7 388 RAB, member RAS oncogene GTPases genenames.org 2.823E-2 4.033E-2
1.181E-1
2.823E-1
 1 65
Show 2 more annotations

13: Coexpression [Display Chart] 1347 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M11197 Housekeeping genes identified as expressed across 19 normal tissues. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.575E-8 3.468E-5 2.699E-4 3.468E-5 6 389
2 M2041 Genes down-regulated in 3T3-L1 cells (fibroblast) induced to differentiate to mature adipocytes and then treated with a TZD derivative AD-5075 [PubChem=128440], a PPARG [GeneID=5468] activator. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.146E-5 1.445E-2
1.125E-1
 2.891E-2 2 13
3 M1047 Genes specifically expressed in samples from patients with pediatric acute myeloid leukemia (AML) bearing inv(16) translocation. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.932E-5 2.149E-2
1.673E-1
7.990E-2
 4 421
4 M2240 Genes up-regulated upon overexpression of PARVB [GeneID=29780] in MDA-MB-231 cells (breast cancer) cultured in 3D Matrigel only. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.382E-5 2.149E-2
1.673E-1
8.597E-2
 4 429
5 M4142 Genes down-regulated in comparison of dendritic cells (DC) stimulated with Gardiquimod (TLR7 agonist) at 0.5 h versus those stimulated with Gardiquimod (TLR7 agonist) at 8 h. MSigDB C7: Immunologic Signatures (v5.1) 1.537E-4 2.335E-2
1.818E-1
2.071E-1
 3 199
6 M6204 Genes up-regulated in polymorphonuclear leukocytes (24h): control versus infection by A. phagocytophilum. MSigDB C7: Immunologic Signatures (v5.1) 1.560E-4 2.335E-2
1.818E-1
2.102E-1
 3 200
7 GSE40274 CTRL VS FOXP3 TRANSDUCED ACTIVATED CD4 TCELL DN Genes down-regulated in CD4 T conv: control versus over-expression of FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v5.1) 1.560E-4 2.335E-2
1.818E-1
2.102E-1
 3 200
8 GSE41978 ID2 KO VS ID2 KO AND BIM KO KLRG1 LOW EFFECTOR CD8 TCELL DN Genes down-regulated in KLRG1 low [GeneID=10219] CD8 T effector cells during infection: ID2 [GeneID=3398] knockout versus ID2 and BCL2L11 [GeneID=3398;10018] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.560E-4 2.335E-2
1.818E-1
2.102E-1
 3 200
9 GSE19198 CTRL VS IL21 TREATED TCELL 6H DN Genes down-regulated in T cells: control (0h) versus IL21 [GeneID=59067] treatment for 6h. MSigDB C7: Immunologic Signatures (v5.1) 1.560E-4 2.335E-2
1.818E-1
2.102E-1
 3 200
10 M11504 Genes down-regulated in prostate cancer vs benign prostate tissue, based on a meta-analysis of five gene expression profiling studies. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.129E-4 2.867E-2
2.232E-1
2.867E-1
 2 40
11 M16977 Genes up-regulated in more than one of several human hepatoma cell lines by TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.333E-4 3.876E-2
3.017E-1
4.489E-1
 2 50
12 M5547 Age up-regulated genes in the human frontal cortex. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.453E-4 3.876E-2
3.017E-1
4.652E-1
 3 262
Show 7 more annotations

14: Coexpression Atlas [Display Chart] 699 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 54Dn SubClass 54Dn 1SK Top 500 All 54Dn SubClass 54Dn 1SK Top 500 All Brain Map - Allen iN 1.256E-5 8.783E-3
6.260E-2
 8.783E-3 5 461
2 PCBC ratio DE blastocyst vs DE cord blood cfr-2X-p05 DE blastocyst vs DE cord blood-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 4.063E-5 1.268E-2
9.038E-2
 2.840E-2 3 96
3 Lungmap Mouse e16.5 Epithelial SubClass Proliferative AT1 Progenitor Top 500 Cluster 4 Mouse Lung E16.5 Epithelial Proliferative AT1 Progenitor c4 Lungmap Mouse Single Cell (Lungmap.net) 6.452E-5 1.268E-2
9.038E-2
 4.510E-2 2 17
4 Lungmap Mouse e18.5 Epithelial (GSE52583) SubClass AT1 Top 500 Cluster 1 Mouse Lung E18.5 Epithelial AT1 c1 Lungmap Mouse Single Cell (Lungmap.net) 7.256E-5 1.268E-2
9.038E-2
5.072E-2
 2 18
5 54SK Top 500 All 54SK Top 500 All Brain Map - Allen iN 3.222E-4 3.169E-2
2.259E-1
2.252E-1
 4 488
6 80Dn Top 500 All 80Dn Top 500 All Brain Map - Allen iN 3.376E-4 3.169E-2
2.259E-1
2.360E-1
 4 494
7 astrocytes Top 500 All astrocytes Top 500 All Brain Map - Barres 3.428E-4 3.169E-2
2.259E-1
2.396E-1
 4 496
8 Lungmap Mouse e18.5 Epithelial (GSE52583) Top 500 Cluster 1 Mouse Lung E18.5 Epithelial top 500 c1 Lungmap Mouse Single Cell (Lungmap.net) 3.666E-4 3.169E-2
2.259E-1
2.562E-1
 2 40
9 ratio MESO vs SC 2500 K4 ratio induced-Mesoderm vs StemCell top-relative-expression-ranked 2500 k-means-cluster#4 PCBC 4.845E-4 3.169E-2
2.259E-1
3.387E-1
 3 222
10 PP MEG 2500 K3 PP MEG top-relative-expression-ranked 2500 k-means-cluster#3 PCBC 4.845E-4 3.169E-2
2.259E-1
3.387E-1
 3 222
11 ratio SC-cbCD34 vs SC-blastocyst 1000 K1 ratio StemCell-derived-from CD34-iPSC vs StemCell-blastocyst top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 5.105E-4 3.169E-2
2.259E-1
3.568E-1
 3 226
12 ratio EB-blastocyst vs EB-cbCD34 1000 K5 ratio EmbryoidBody-blastocyst vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 1000 k-means-cluster#5 PCBC 5.441E-4 3.169E-2
2.259E-1
3.803E-1
 3 231
13 astrocytes Top 500 Cluster 0 astrocytes Top 500 Cluster 0 Brain Map - Barres 7.978E-4 3.559E-2
2.537E-1
5.577E-1
 2 59
14 ratio EB-fibro vs EB-blastocyst 1000 K4 ratio EmbryoidBody-fibro vs EmbryoidBody-blastocyst top-relative-expression-ranked 1000 k-means-cluster#4 PCBC 8.377E-4 3.559E-2
2.537E-1
5.856E-1
 3 268
15 54Dn SubClass 54Dn 1SK Top 500 Cluster 0 54Dn SubClass 54Dn 1SK Top 500 Cluster 0 Brain Map - Allen iN 8.807E-4 3.559E-2
2.537E-1
6.156E-1
 2 62
16 ratio SC-blastocyst vs cbCD34 1000 K1 ratio StemCell-blastocyst vs cbCD34 top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 9.121E-4 3.559E-2
2.537E-1
6.376E-1
 3 276
17 ratio EB-cbCD34 vs EB-blastocyst 1000 K1 ratio EmbryoidBody-derived-from CD34-iPSC vs EmbryoidBody-blastocyst top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 9.509E-4 3.559E-2
2.537E-1
6.647E-1
 3 280
18 Facebase RNAseq ratio e9.5 MaxillaryArch vs Mandibular 2500 K4 FacebaseRNAseq ratio e9.5 MaxillaryArch vs Mandibular top-relative-expression-ranked 2500 k-means-cluster#4 FaceBase_RNAseq 9.607E-4 3.559E-2
2.537E-1
6.716E-1
 3 281
19 gudmap kidney P4 CapMesRenVes Crym k1 1000 kidney P4 CapMesRenVes Crym k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 9.675E-4 3.559E-2
2.537E-1
6.763E-1
 2 65
20 endothelial Top 500 Cluster 2 endothelial Top 500 Cluster 2 Brain Map - Barres 1.058E-3 3.652E-2
2.603E-1
7.397E-1
 2 68
21 ratio EB-fibro vs EB-cbCD34 1000 K3 ratio EmbryoidBody-fibro vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 1000 k-means-cluster#3 PCBC 1.106E-3 3.652E-2
2.603E-1
7.727E-1
 3 295
22 Arv EB-LF 2500 K4 AravindRamakr EmbryoidBody-LF top-relative-expression-ranked 2500 k-means-cluster#4 PCBC 1.149E-3 3.652E-2
2.603E-1
8.033E-1
 3 299
23 ratio SC-blastocyst vs SC-fibro 1000 K5 ratio StemCell-blastocyst vs StemCell-fibro top-relative-expression-ranked 1000 k-means-cluster#5 PCBC 1.205E-3 3.664E-2
2.611E-1
8.426E-1
 3 304
24 BM Top 100 - trigeminal ganglia BM Top 100 - trigeminal ganglia Body Map 1.354E-3 3.782E-2
2.695E-1
9.466E-1
 2 77
25 ratio SC-fibro vs SC-cbCD34 1000 K5 ratio StemCell-fibro vs StemCell-derived-from CD34-iPSC top-relative-expression-ranked 1000 k-means-cluster#5 PCBC 1.422E-3 3.782E-2
2.695E-1
9.942E-1
 3 322
26 ratio SC-fibro vs SC-blastocyst 1000 K4 ratio StemCell-fibro vs StemCell-blastocyst top-relative-expression-ranked 1000 k-means-cluster#4 PCBC 1.435E-3 3.782E-2
2.695E-1
1.000E0
 3 323
27 gudmap kidney adult RenMedVasc Tie2 k3 1000 kidney adult RenMedVasc Tie2 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.461E-3 3.782E-2
2.695E-1
1.000E0
 2 80
28 ratio SC-cbCD34 vs SC-fibro 1000 K2 ratio StemCell-derived-from CD34-iPSC vs StemCell-fibro top-relative-expression-ranked 1000 k-means-cluster#2 PCBC 1.607E-3 3.969E-2
2.829E-1
1.000E0
 3 336
29 GSM777067 100 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 1.647E-3 3.969E-2
2.829E-1
1.000E0
 2 85
30 GSM777050 100 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 1.724E-3 4.018E-2
2.864E-1
1.000E0
 2 87
31 gudmap kidney adult GlomCapSys Tie2 k2 1000 kidney adult GlomCapSys Tie2 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.925E-3 4.342E-2
3.094E-1
1.000E0
 2 92
Show 26 more annotations

15: Computational [Display Chart] 46 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 46 Genes in module 46 MSigDb: C4 - CM: Cancer Modules 2.126E-3 3.695E-2
1.632E-1
9.780E-2
 3 386
2 module 75 Genes in module 75 MSigDb: C4 - CM: Cancer Modules 2.206E-3 3.695E-2
1.632E-1
1.015E-1
 3 391
3 GNF2 DAP3 Neighborhood of DAP3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.410E-3 3.695E-2
1.632E-1
1.108E-1
 2 103

16: MicroRNA [Display Chart] 165 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-9:miRTarbase hsa-miR-9:miRTarbase miRTarbase 8.580E-5 1.416E-2
8.049E-2
 1.416E-2 2 28

17: Drug [Display Chart] 2018 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone CTD 1.949E-5 2.853E-2
2.336E-1
 3.933E-2 4 320
2 MESH:D011471/D007654-T Prostatic Neoplasms affected by Ketoconazole CTD Therapeutic 2.827E-5 2.853E-2
2.336E-1
5.706E-2
 2 15
3 C036006 oxcarbazepine CTD 4.599E-5 3.008E-2
2.463E-1
9.281E-2
 2 19
4 CID000001800 5-amidinobenzimidazole Stitch 6.973E-5 3.008E-2
2.463E-1
1.407E-1
 3 154
5 CID000000253 AC124 Stitch 9.849E-5 3.008E-2
2.463E-1
1.988E-1
 3 173
6 6943 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.054E-4 3.008E-2
2.463E-1
2.127E-1
 3 177
7 CID000445722 AC1L9IGO Stitch 1.182E-4 3.008E-2
2.463E-1
2.386E-1
 3 184
8 D009761 Nystatin CTD 1.246E-4 3.008E-2
2.463E-1
2.515E-1
 2 31
9 D010433 Pentylenetetrazole CTD 1.425E-4 3.008E-2
2.463E-1
2.876E-1
 3 196
10 6496 DN Nisoxetine hydrochloride [57754-86-6]; Down 200; 13uM; MCF7; HT HG-U133A Broad Institute CMAP 1.491E-4 3.008E-2
2.463E-1
3.008E-1
 3 199
11 D003633 Dichlorodiphenyl Dichloroethylene CTD 2.373E-4 3.535E-2
2.894E-1
4.789E-1
 3 233
12 D001414 Bacitracin CTD 2.525E-4 3.535E-2
2.894E-1
5.096E-1
 2 44
13 MESH:D011471/C008493-T Prostatic Neoplasms affected by methylselenic acid CTD Therapeutic 2.642E-4 3.535E-2
2.894E-1
5.331E-1
 2 45
14 OMIM:608579/C047781-M SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO affected by lamotrigine CTD Marker 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
15 MESH:D005076/D002220-M Exanthema affected by Carbamazepine CTD Marker 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
16 CID000161524 polyelectrolyte 60 Stitch 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
17 MESH:D013262/C036006-M Stevens-Johnson Syndrome affected by oxcarbazepine CTD Marker 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
18 MESH:D004816/D002220-M Epidermal Necrolysis, Toxic affected by Carbamazepine CTD Marker 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
19 MESH:D013262/D010672-M Stevens-Johnson Syndrome affected by Phenytoin CTD Marker 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
20 MESH:D004816/C036006-M Epidermal Necrolysis, Toxic affected by oxcarbazepine CTD Marker 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
21 MESH:D013262/C047781-M Stevens-Johnson Syndrome affected by lamotrigine CTD Marker 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
22 MESH:D013262/D002220-M Stevens-Johnson Syndrome affected by Carbamazepine CTD Marker 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
23 CID000124862 NFAP Stitch 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
24 MESH:D003875/D010672-M Drug Eruptions affected by Phenytoin CTD Marker 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
25 CID000031799 l9-9 Stitch 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
26 MESH:D004816/C047781-M Epidermal Necrolysis, Toxic affected by lamotrigine CTD Marker 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
27 CID005232988 AC1NR1RA Stitch 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
28 MESH:D009389/D004958-M Neovascularization, Pathologic affected by Estradiol CTD Marker 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
29 CID000059743 DN-2327 Stitch 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
30 MESH:D004816/D010672-M Epidermal Necrolysis, Toxic affected by Phenytoin CTD Marker 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
31 MESH:D056486/D005436-M Drug-Induced Liver Injury affected by Floxacillin CTD Marker 5.430E-4 3.535E-2
2.894E-1
1.000E0
 1 1
32 CID004636205 AC1NE3ZI Stitch 6.215E-4 3.652E-2
2.990E-1
1.000E0
 2 69
33 D014112 Toxaphene CTD 6.765E-4 3.652E-2
2.990E-1
1.000E0
 2 72
34 CID005037551 NSC603722 Stitch 7.934E-4 3.652E-2
2.990E-1
1.000E0
 2 78
35 CID000002538 NSC302991 Stitch 7.989E-4 3.652E-2
2.990E-1
1.000E0
 3 353
36 D002713 Chlorine CTD 8.662E-4 3.652E-2
2.990E-1
1.000E0
 3 363
37 D020888 Vigabatrin CTD 1.008E-3 3.652E-2
2.990E-1
1.000E0
 2 88
38 MESH:D015658/C106538-T HIV Infections affected by abacavir CTD Therapeutic 1.086E-3 3.652E-2
2.990E-1
1.000E0
 1 2
39 CID000000348 AC1L191G Stitch 1.086E-3 3.652E-2
2.990E-1
1.000E0
 1 2
40 CID011953586 (2S)-2-[[(2S)-2-[5-[[(2S)-2-[5-[[(2S)-2-acetamido-3-(2-naphthyl)propanoyl]amino]pentanoylamino]-3-(2-naphthyl)propanoyl]amino]pentanoylamino]-3-(2-naphthyl)propanoyl]amino]-3-methyl-valeramide Stitch 1.086E-3 3.652E-2
2.990E-1
1.000E0
 1 2
41 CID000494401 AC1LASX4 Stitch 1.086E-3 3.652E-2
2.990E-1
1.000E0
 1 2
42 MESH:D008545/D016190-T Melanoma affected by Carboplatin CTD Therapeutic 1.086E-3 3.652E-2
2.990E-1
1.000E0
 1 2
43 MESH:D004342/C106538-M Drug Hypersensitivity affected by abacavir CTD Marker 1.086E-3 3.652E-2
2.990E-1
1.000E0
 1 2
44 CID000028434 diHCl Stitch 1.086E-3 3.652E-2
2.990E-1
1.000E0
 1 2
45 CID005315268 AC1NSSW1 Stitch 1.086E-3 3.652E-2
2.990E-1
1.000E0
 1 2
46 CID003017427 AC1MI4QS Stitch 1.086E-3 3.652E-2
2.990E-1
1.000E0
 1 2
47 CID000159976 azaphen Stitch 1.086E-3 3.652E-2
2.990E-1
1.000E0
 1 2
48 CID000135052 Maopc Stitch 1.086E-3 3.652E-2
2.990E-1
1.000E0
 1 2
49 C081064 LY 231617 CTD 1.086E-3 3.652E-2
2.990E-1
1.000E0
 1 2
50 C053091 lomefloxacin CTD 1.086E-3 3.652E-2
2.990E-1
1.000E0
 1 2
Show 45 more annotations

18: Disease [Display Chart] 568 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0409651 Seropositive rheumatoid arthritis DisGeNET BeFree 5.868E-5 8.794E-3
6.086E-2
 3.333E-2 2 19
2 umls:C0011311 Dengue Fever DisGeNET Curated 1.192E-4 8.794E-3
6.086E-2
6.771E-2
 3 165
3 umls:C0270853 Myoclonic Epilepsy, Juvenile DisGeNET Curated 3.074E-4 8.794E-3
6.086E-2
1.746E-1
 2 43
4 umls:C0497169 hiv-infection/aids DisGeNET BeFree 4.161E-4 8.794E-3
6.086E-2
2.363E-1
 2 50
5 umls:C0041755 Adverse reaction to drug DisGeNET Curated 4.854E-4 8.794E-3
6.086E-2
2.757E-1
 2 54
6 118220 CHARCOT-MARIE-TOOTH DISEASE, DEMYELINATING, TYPE 1A; CMT1A OMIM 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
7 cv:C1861827 Cataract, nuclear diffuse nonprogressive Clinical Variations 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
8 umls:C1274933 Drug-Induced Stevens Johnson Syndrome DisGeNET BeFree 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
9 umls:C0262576 Nerve paralysis DisGeNET BeFree 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
10 cv:C3150741 Common variable immunodeficiency 6 Clinical Variations 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
11 umls:C0494491 Mononeuropathies DisGeNET BeFree 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
12 cv:C1840547 Abacavir hypersensitivity Clinical Variations 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
13 139393 GUILLAIN-BARRE SYNDROME, FAMILIAL; GBS OMIM 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
14 118300 CHARCOT-MARIE-TOOTH DISEASE AND DEAFNESS OMIM 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
15 cv:C0038013 Ankylosing spondylitis Clinical Variations 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
16 umls:C0795865 Chromosome 17, trisomy 17p DisGeNET BeFree 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
17 umls:C1840547 ABACAVIR HYPERSENSITIVITY, SUSCEPTIBILITY TO DisGeNET Curated 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
18 613496 IMMUNODEFICIENCY, COMMON VARIABLE, 6; CVID6 OMIM 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
19 umls:C0014347 Enterobacteriaceae Infections DisGeNET BeFree 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
20 umls:C0340305 Inferior Wall Myocardial Infarction DisGeNET BeFree 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
21 umls:C4014641 DIAMOND-BLACKFAN ANEMIA 13 DisGeNET Curated 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
22 162500 NEUROPATHY, HEREDITARY, WITH LIABILITY TO PRESSURE PALSIES; HNPP OMIM 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
23 umls:C0409667 Juvenile Chronic Polyarthritis DisGeNET BeFree 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
24 cv:C1841700 Guillain-Barre syndrome, familial Clinical Variations 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
25 umls:C0039273 Talipes cavus DisGeNET BeFree 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
26 cv:CN077964 Carbamazepine response Clinical Variations 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
27 umls:C1840548 SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO (finding) DisGeNET Curated 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
28 umls:C0155118 Corneal degeneration DisGeNET BeFree 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
29 cv:C0393814 Hereditary liability to pressure palsies Clinical Variations 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
30 cv:CN197014 Diamond-Blackfan anemia 13 Clinical Variations 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
31 cv:C0270911 Charcot-Marie-Tooth disease, type IA Clinical Variations 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
32 cv:C1861669 Charcot-Marie-Tooth disease, type IE Clinical Variations 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
33 cv:CN160494 Allopurinol response Clinical Variations 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
34 cv:C1835923 Retinitis pigmentosa 31 Clinical Variations 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
35 umls:C2931686 Charcot-Marie-Tooth disease, Type 1E DisGeNET Curated 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
36 609923 RETINITIS PIGMENTOSA 31; RP31 OMIM 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
37 cv:CN077825 Carbamazepine hypersensitivity Clinical Variations 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
38 umls:C1835923 Retinitis Pigmentosa 31 DisGeNET Curated 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
39 umls:C0741395 back pain mechanical DisGeNET BeFree 6.192E-4 8.794E-3
6.086E-2
3.517E-1
 1 1
40 umls:C1334177 Infiltrating Cervical Carcinoma DisGeNET BeFree 6.193E-4 8.794E-3
6.086E-2
3.518E-1
 2 61
41 umls:C3495559 Juvenile arthritis DisGeNET Curated 6.389E-4 8.851E-3
6.125E-2
3.629E-1
 3 292
42 umls:C0595936 Aqueous Humor Disorders DisGeNET BeFree 7.247E-4 9.573E-3
6.625E-2
4.116E-1
 2 66
43 umls:C0019100 Severe Dengue DisGeNET Curated 7.247E-4 9.573E-3
6.625E-2
4.116E-1
 2 66
44 umls:C0005967 Bone neoplasms DisGeNET Curated 9.348E-4 1.114E-2
7.709E-2
5.310E-1
 2 75
45 umls:C3495591 Charcot-Marie-Tooth Disease, Demyelinating, Type 1e DisGeNET Curated 1.238E-3 1.114E-2
7.709E-2
7.032E-1
 1 2
46 cv:C0205713 Roussy-Lévy syndrome Clinical Variations 1.238E-3 1.114E-2
7.709E-2
7.032E-1
 1 2
47 180800 ROUSSY-LEVY HEREDITARY AREFLEXIC DYSTASIA OMIM 1.238E-3 1.114E-2
7.709E-2
7.032E-1
 1 2
48 umls:C0409676 Juvenile spondyloarthropathy DisGeNET BeFree 1.238E-3 1.114E-2
7.709E-2
7.032E-1
 1 2
49 umls:C0728829 Congenital pes cavus DisGeNET BeFree 1.238E-3 1.114E-2
7.709E-2
7.032E-1
 1 2
50 608579 SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO OMIM 1.238E-3 1.114E-2
7.709E-2
7.032E-1
 1 2
Show 45 more annotations